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| G
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Abca8
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ATP binding cassette subfamily A member 8
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increases uptake multiple interactions
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ISO
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ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; dofequidar inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; ochratoxin A inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Verapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]
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CTD |
PMID:12379217 |
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NCBI chr10:95,416,984...95,490,647
Ensembl chr10:95,416,205...95,490,452
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| G
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Abcb11
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ATP binding cassette subfamily B member 11
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decreases activity multiple interactions affects localization decreases secretion
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EXP
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estradiol-17 beta-glucuronide results in decreased activity of ABCB11 protein estradiol-17 beta-glucuronide affects the localization of and affects the activity of ABCB11 protein; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein] estradiol-17 beta-glucuronide results in decreased secretion of ABCB11 protein
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CTD |
PMID:10869290 PMID:12702498 PMID:12893835 PMID:15763547 PMID:18972403 PMID:20815017 PMID:29090346 More...
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NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
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| G
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Abcb1a
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ATP binding cassette subfamily B member 1A
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affects response to substance increases transport multiple interactions
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ISO EXP
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ABCB1 affects the susceptibility to estradiol-17 beta-glucuronide ABCB1 results in increased transport of estradiol-17 beta-glucuronide Daunorubicin inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol 17-glucuronide inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]
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CTD |
PMID:9794924 |
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NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
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| G
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Abcb4
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ATP binding cassette subfamily B member 4
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affects export
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ISO
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ABCB4 protein affects the export of estradiol-17 beta-glucuronide
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CTD |
PMID:11302927 |
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NCBI chr 4:26,106,895...26,164,440
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| G
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Abcc1
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ATP binding cassette subfamily C member 1
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affects transport increases transport increases uptake multiple interactions increases export
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ISO
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ABCC1 protein affects the transport of estradiol-17 beta-glucuronide ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide; ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide [Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein mutant form]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein]; estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; kaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Quercetin affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide] ABCC1 protein results in increased export of estradiol-17 beta-glucuronide
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CTD |
PMID:11278867 PMID:11306701 PMID:15459206 PMID:18336795 PMID:21918036 PMID:27297967 More...
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NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
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| G
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Abcc2
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ATP binding cassette subfamily C member 2
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affects export multiple interactions affects transport affects response to substance increases transport affects localization decreases secretion
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ISO EXP
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ABCC2 protein affects the export of estradiol-17 beta-glucuronide [Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Bile Acids and Salts promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide promotes the reaction [ABCC2 protein affects the transport of Bile Acids and Salts]; estradiol-17 beta-glucuronide results in decreased activity of and affects the localization of ABCC2 protein; Ethinyl Estradiol metabolite promotes the reaction [ABCC2 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Indomethacin promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Penicillin G promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; sulfanitran promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide] ABCC2 protein affects the susceptibility to estradiol-17 beta-glucuronide ABCC2 protein modified form results in increased transport of estradiol-17 beta-glucuronide; ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide abietic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; AG 1879 inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Bucladesine inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; CL 387785 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; EGF protein inhibits the reaction [Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]; EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein; Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Glycyrrhetinic Acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein] estradiol-17 beta-glucuronide results in decreased secretion of ABCC2 protein
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CTD |
PMID:11500505 PMID:12029626 PMID:12642476 PMID:12702498 PMID:12702717 PMID:12704183 PMID:12893835 PMID:14722317 PMID:15652233 PMID:15846474 PMID:15901800 PMID:15904671 PMID:17463180 PMID:18180276 PMID:18436619 PMID:18972403 PMID:19628752 PMID:20815017 PMID:25813982 PMID:29052767 PMID:29090346 PMID:32003934 More...
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NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
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| G
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Abcc3
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ATP binding cassette subfamily C member 3
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affects transport increases activity increases transport multiple interactions
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ISO
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ABCC3 protein affects the transport of estradiol-17 beta-glucuronide estradiol-17 beta-glucuronide results in increased activity of ABCC3 protein ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide Bile Acids and Salts inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Ethinyl Estradiol metabolite promotes the reaction [ABCC3 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Indomethacin inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; resveratrol metabolite promotes the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide]; resveratrol-4'-O-glucuronide inhibits the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide]
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CTD |
PMID:12704183 PMID:14722317 PMID:17569508 PMID:19114588 |
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NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494
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| G
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Abcc4
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ATP binding cassette subfamily C member 4
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increases transport increases export affects export
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ISO
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ABCC4 protein results in increased transport of estradiol-17 beta-glucuronide ABCC4 protein results in increased export of estradiol-17 beta-glucuronide ABCC4 gene SNP affects the export of estradiol-17 beta-glucuronide
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CTD |
PMID:11856762 PMID:27659809 |
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NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375
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| G
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Abcg2
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ATP binding cassette subfamily G member 2
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increases transport multiple interactions
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ISO
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ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide Glycyrrhetinic Acid inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]; lapatinib inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]
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CTD |
PMID:18436619 PMID:18829547 |
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NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
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| G
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Akt1
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AKT serine/threonine kinase 1
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increases phosphorylation multiple interactions
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EXP
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estradiol-17 beta-glucuronide results in increased phosphorylation of AKT1 protein tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of AKT1 protein]
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CTD |
PMID:29090346 |
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NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
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| G
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Aqp8
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aquaporin 8
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decreases expression
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EXP
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estradiol-17 beta-glucuronide results in decreased expression of AQP8 protein
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CTD |
PMID:17110522 |
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NCBI chr 1:187,424,314...187,430,243
Ensembl chr 1:187,424,417...187,430,242
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| G
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Egf
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epidermal growth factor
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multiple interactions
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EXP
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EGF protein inhibits the reaction [fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]
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CTD |
PMID:25813982 |
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NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297
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| G
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Egfr
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epidermal growth factor receptor
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multiple interactions
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EXP
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EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein]
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CTD |
PMID:25813982 |
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NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358
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| G
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Esr1
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estrogen receptor 1
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multiple interactions
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EXP
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estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of ESR1 protein
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CTD |
PMID:25813982 |
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NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
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| G
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Hgf
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hepatocyte growth factor
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multiple interactions increases uptake
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EXP
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[HGF protein results in increased expression of SLCO1A1 protein] which results in increased uptake of estradiol-17 beta-glucuronide; ochratoxin A inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; SLCO1A1 protein affects the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]
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CTD |
PMID:18031729 |
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NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851
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| G
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Igf1r
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insulin-like growth factor 1 receptor
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multiple interactions increases phosphorylation
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EXP
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4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of IGF1R protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]
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CTD |
PMID:29090346 |
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NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664
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| G
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Ocln
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occludin
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affects localization
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EXP
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estradiol-17 beta-glucuronide affects the localization of OCLN protein
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CTD |
PMID:17463180 |
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NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
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| G
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Prkca
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protein kinase C, alpha
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multiple interactions affects localization
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EXP
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Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of PRKCA protein]
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CTD |
PMID:18972403 |
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NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572
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| G
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Slc22a8
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solute carrier family 22 member 8
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multiple interactions affects transport
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EXP ISO
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estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine] SLC22A8 protein affects the transport of estradiol-17 beta-glucuronide
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CTD |
PMID:11306713 PMID:15319347 |
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NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588
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| G
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Slco1a1
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solute carrier organic anion transporter family, member 1a1
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increases import multiple interactions increases uptake
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EXP
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SLCO1A1 protein results in increased import of estradiol-17 beta-glucuronide [HGF protein results in increased expression of SLCO1A1 protein] which results in increased uptake of estradiol-17 beta-glucuronide; Desoxycorticosterone inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]; hexadecafluoro-nonanoic acid inhibits the reaction [SLCO1A1 protein results in increased import of estradiol-17 beta-glucuronide]; Ibuprofen inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Indomethacin inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Ketoprofen inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Naproxen inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]; perfluorodecanoic acid inhibits the reaction [SLCO1A1 protein results in increased import of estradiol-17 beta-glucuronide]; perfluoroundecanoic acid inhibits the reaction [SLCO1A1 protein results in increased import of estradiol-17 beta-glucuronide]; Quinidine inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]; SLCO1A1 protein affects the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]
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CTD |
PMID:11883641 PMID:18031729 PMID:19915082 PMID:34619012 |
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NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992
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| G
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Slco1a4
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solute carrier organic anion transporter family, member 1a4
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affects uptake multiple interactions increases uptake
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ISO EXP
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SLCO1A4 protein affects the uptake of estradiol-17 beta-glucuronide Bile Acids and Salts inhibits the reaction [SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide]
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CTD |
PMID:19464309 PMID:21561886 |
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NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816
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| G
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Slco1b2
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solute carrier organic anion transporter family member 1B2
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increases uptake multiple interactions affects response to substance increases import
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EXP ISO
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SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide Bile Acids and Salts inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide] SLCO1B2 protein affects the susceptibility to estradiol-17 beta-glucuronide 2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; darolutamide inhibits the reaction [SLCO1B3 protein results in increased import of estradiol-17 beta-glucuronide]; darolutamide metabolite inhibits the reaction [SLCO1B3 protein results in increased import of estradiol-17 beta-glucuronide]; pentabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide] SLCO1B3 protein results in increased import of estradiol-17 beta-glucuronide; SLCO1B3 results in increased import of estradiol-17 beta-glucuronide
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CTD |
PMID:18180276 PMID:18296417 PMID:19464309 PMID:20176623 PMID:32003934 PMID:32305507 PMID:34619012 PMID:38491867 More...
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NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083
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| G
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Src
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SRC proto-oncogene, non-receptor tyrosine kinase
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multiple interactions
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EXP
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estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]
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CTD |
PMID:25813982 |
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NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462
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| G
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Tjp1
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tight junction protein 1
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affects localization
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EXP
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estradiol-17 beta-glucuronide affects the localization of TJP1 protein
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CTD |
PMID:17463180 |
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NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158
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