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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:SB-202190
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Accession:CHEBI:79090 term browser browse the term
Definition:A member of the class of imidazoles that is 1H-imidazole in which the hydrogens at positions 2, 4, and 5 are replaced by 4-hydroxyphenyl, pyridin-4-yl, and 4-fluorophenyl groups, respectively. It is a widely used inhibitor of mitogen-activated protein kinase (MAPK) alpha and beta.
Synonyms:exact_synonym: 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
 related_synonym: 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole;   Formula=C20H14FN3O;   InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24);   InChIKey=QHKYPYXTTXKZST-UHFFFAOYSA-N;   SB202190;   SMILES=Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
 xref: CAS:152121-30-7;   PMID:11040446;   PMID:16183336;   PMID:18995898;   PMID:21853067;   PMID:22253611;   PMID:22986232;   PMID:24455679;   PMID:9632706;   PMID:9738669;   Reaxys:10467168


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SB-202190 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO SB-202190 inhibits the reaction [benzo[a]pyrene and polycyclic arene increases expression of CYP1A1 mRNA in lung epithelial cell] RGD PMID:20464547 RGD:152975620 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions ISO SB-202190 inhibits the reaction [ benzo[a]pyrene and polycyclic arene increases expression of FGF9 mRNA in lung epithelial cell] RGD PMID:20464547 RGD:152975620 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO SB-202190 inhibits the reaction [benzo[a]pyrene and polycyclic arene increases expression of IL1A mRNA in lung epithelial cell] RGD PMID:20464547 RGD:152975620 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          apoptosis inducer 13663
            SB-202190 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  heteroarene 17155
                                    monocyclic heteroarene 14983
                                      azole 14506
                                        diazole 10772
                                          imidazoles 10221
                                            SB-202190 3
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