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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor
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Accession:CHEBI:78728 term browser browse the term
Definition:An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of Delta(24)-sterol reductase (EC 1.3.1.72).
Synonyms:related_synonym: Delta(24)-sterol reductase (EC 1.3.1.72) inhibitors;   Delta(24)-sterol reductase inhibitor;   Delta(24)-sterol reductase inhibitors;   EC 1.3.1.72 inhibitor;   EC 1.3.1.72 inhibitors;   lanosterol Delta (24)-reductase;   sterol:NADP(+) Delta(24)-oxidoreductase
 xref: Wikipedia:Delta24-sterol_reductase


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3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpc1 glypican 1 decreases degradation ISO 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one results in decreased degradation of GPC1 protein CTD PMID:21642435 NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one inhibits the reaction [[Lipopolysaccharides results in increased susceptibility to Silicon Dioxide] which results in increased secretion of IL1B protein] CTD PMID:36860548 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        biochemical role 19574
          enzyme inhibitor 18775
            EC 1.* (oxidoreductase) inhibitor 17565
              EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor 6694
                EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor 3187
                  EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor 2
                    25-azacoprostane 0
                    3beta-(2-diethylaminoethoxy)androst-5-en-17-one 0
                    3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride 2
                    brassicasterol + 0
paths to the root