Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxytocin
go back to main search page
Accession:CHEBI:7872 term browser browse the term
Definition:A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour.
Synonyms:exact_synonym: 1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide
 related_synonym: (1-Hemicystine)oxytocin;   3-Isoleucine-8-leucine vasopressin;   Endopituitrina;   Formula=C43H66N12O12S2;   InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1;   InChIKey=XNOPRXBHLZRZKH-DSZYJQQASA-N;   L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic(1-6)-disulfide;   OT;   OXT;   Ocytocin;   Orasthin;   Pitocin;   Piton S;   SMILES=[H][C@]1(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)[C@@H](C)CC;   Syntocinon;   oxitocina;   oxytocine;   oxytocinum
 xref: Beilstein:3586108;   CAS:50-56-6;   DrugBank:DB00107;   Drug_Central:2042;   HMDB:HMDB0002865;   KEGG:C00746;   KEGG:D00089
 xref_mesh: MESH:D010121
 xref: PMID:10027619;   PMID:10834934;   PMID:10949083;   PMID:10949750;   PMID:10983343;   PMID:11134819;   PMID:13305558;   PMID:15815422;   PMID:18593851;   PMID:18988842;   PMID:19104313;   PMID:19369205;   PMID:19482229;   PMID:24706799;   PMID:25209411;   PMID:32509991;   PMID:32683141;   PMID:32979349;   PMID:33192340;   Patent:US2938891;   Patent:US3076797;   Wikipedia:Oxytocin


show annotations for term's descendants           Sort by:
oxytocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator increases expression EXP Oxytocin results in increased expression of BCL2 protein CTD PMID:23707249 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Egfr epidermal growth factor receptor increases expression EXP Oxytocin results in increased expression of EGFR protein modified form CTD PMID:23707249 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP Oxytocin results in increased expression of FOS protein
Oxytocin inhibits the reaction [Methamphetamine results in increased expression of FOS protein]		 CTD PMID:20731630 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gdf9 growth differentiation factor 9 increases expression EXP Oxytocin results in increased expression of GDF9 protein CTD PMID:23707249 NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672 		JBrowse link
G Has2 hyaluronan synthase 2 increases expression EXP Oxytocin results in increased expression of HAS2 protein CTD PMID:23707249 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions
increases expression		 ISO KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein]]; KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein]]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of KLF4 protein]
Oxytocin results in increased expression of KLF4 mRNA; Oxytocin results in increased expression of KLF4 protein		 CTD PMID:29104011 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 multiple interactions ISO MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein] CTD PMID:29104011 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression EXP Oxytocin results in increased expression of MAPK1 protein modified form CTD PMID:23707249 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression EXP Oxytocin results in increased expression of MAPK3 protein modified form CTD PMID:23707249 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mef2a myocyte enhancer factor 2a multiple interactions ISO MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein] CTD PMID:29104011 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 multiple interactions EXP Oxytocin inhibits the reaction [Cisplatin results in increased expression of MKNK2 mRNA] CTD PMID:21993003 NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases response to substance EXP MMP2 protein results in decreased susceptibility to Oxytocin CTD PMID:22496348 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases response to substance EXP MMP9 protein results in decreased susceptibility to Oxytocin CTD PMID:22496348 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Noxo1 NADPH oxidase organizer 1 multiple interactions EXP Oxytocin inhibits the reaction [Cisplatin results in increased expression of NOXO1 mRNA] CTD PMID:21993003 NCBI chr10:13,723,253...13,726,008
Ensembl chr10:13,721,473...13,726,061 		JBrowse link
G Oxtr oxytocin receptor multiple interactions
increases expression		 EXP
ISO		 Oxytocin analog binds to and results in decreased activity of OXTR protein
guizhi-fuling inhibits the reaction [Oxytocin results in increased expression of OXTR protein]		 CTD PMID:9502799 PMID:27340106 NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674 		JBrowse link
G Plcb1 phospholipase C beta 1 affects localization ISO Oxytocin affects the localization of PLCB1 protein CTD PMID:11579162 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcb3 phospholipase C beta 3 affects localization ISO Oxytocin affects the localization of PLCB3 protein CTD PMID:11579162 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP
ISO		 Oxytocin results in increased expression of PTGS2 protein
guizhi-fuling inhibits the reaction [Oxytocin results in increased expression of PTGS2 protein]		 CTD PMID:23707249 PMID:27340106 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sele selectin E multiple interactions ISO KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein]]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE mRNA]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein] CTD PMID:29104011 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression EXP Oxytocin results in increased expression of TNFAIP6 protein CTD PMID:23707249 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein]]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 mRNA]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein] CTD PMID:29104011 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        molecular messenger 18688
          hormone 18518
            peptide hormone 151
              oxytocin 21
                demoxytocin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organochalcogen compound 19293
                                organooxygen compound 19209
                                  carbon oxoacid 18678
                                    carboxylic acid 18675
                                      carboacyl group 17725
                                        univalent carboacyl group 17725
                                          carbamoyl group 17577
                                            carboxamide 17577
                                              peptide 11450
                                                cyclic peptide 8930
                                                  heterodetic cyclic peptide 1727
                                                    oxytocin 21
                                                      demoxytocin 0
paths to the root