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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cumene hydroperoxide
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Accession:CHEBI:78673 term browser browse the term
Definition:A peroxol that is cumene in which the alpha-hydrogen is replaced by a hydroperoxy group.
Synonyms:related_synonym: 1-Methyl-1-phenylethyl hydroperoxide;   7-Cumyl hydroperoxide;   CHP;   Cumenyl hydroperoxide;   Cumolhydroperoxid;   Cumyl hydroperoxide;   Formula=C9H12O2;   Hydroperoxyde de cumene;   Hydroperoxyde de cumyle;   InChI=1S/C9H12O2/c1-9(2,11-10)8-6-4-3-5-7-8/h3-7,10H,1-2H3;   InChIKey=YQHLDYVWEZKEOX-UHFFFAOYSA-N;   Isopropylbenzene hydroperoxide;   SMILES=CC(C)(OO)c1ccccc1;   alpha,alpha-Dimethylbenzyl hydroperoxide;   alpha-Cumene hydroperoxide;   alpha-Cumyl hydroperoxide
 xref: CAS:80-15-9
 xref_mesh: MESH:C007164
 xref: MetaCyc:CPD0-1449;   PMID:23357941;   PMID:23707950;   PMID:23767299;   PMID:24073228;   PMID:24492382;   PMID:26985019;   Reaxys:1908117;   Wikipedia:Cumene_hydroperoxide


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cumene hydroperoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
increases activity
multiple interactions		 ISO
EXP		 cumene hydroperoxide results in decreased activity of CAT protein
cumene hydroperoxide results in increased activity of CAT protein
Iron promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]		 CTD PMID:12065085 PMID:12423650 PMID:16928893 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects oxidation EXP CYP2B1 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects oxidation EXP CYP2B6 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects oxidation ISO CYP2C19 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects oxidation ISO CYP2C8 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 affects oxidation EXP CYP2D1 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 multiple interactions ISO [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-1,6-quinone; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-3,6-quinone; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-6,12-quinone; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-dihydrobenzo(a)pyrene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-Dimethyl-1,2-benzanthracene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Aflatoxin B1; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Tretinoin CTD PMID:19713358 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 multiple interactions
decreases expression		 EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]; Vitamin E analog inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]
cumene hydroperoxide results in decreased expression of EEF2; cumene hydroperoxide results in decreased expression of EEF2 protein		 CTD PMID:16469450 PMID:17510559 PMID:19447174 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions ISO cumene hydroperoxide results in increased phosphorylation of and results in increased activity of FGFR2 protein CTD PMID:12717419 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP cumene hydroperoxide results in increased activity of G6PD protein CTD PMID:16928893 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO cumene hydroperoxide results in increased expression of GAPDH protein CTD PMID:11295360 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO cumene hydroperoxide results in increased expression of GCLC mRNA CTD PMID:30547568 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO cumene hydroperoxide results in increased expression of GCLM mRNA CTD PMID:30547568 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases response to substance
increases reduction
increases metabolic processing		 ISO GPX1 protein results in decreased susceptibility to cumene hydroperoxide
GPX1 protein results in increased reduction of cumene hydroperoxide
GPX1 protein results in increased metabolism of cumene hydroperoxide		 CTD PMID:1740415 PMID:1939125 PMID:8428933 PMID:9126277 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases reduction ISO GPX2 protein results in increased reduction of cumene hydroperoxide CTD PMID:8428933 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance ISO GPX4 results in decreased susceptibility to cumene hydroperoxide CTD PMID:18206984 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP cumene hydroperoxide results in decreased activity of GSR protein CTD PMID:16928893 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases metabolic processing ISO GSTA1 protein results in increased metabolism of cumene hydroperoxide CTD PMID:1985777 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases metabolic processing
increases metabolic processing		 ISO GSTA2 protein polymorphism results in decreased metabolism of cumene hydroperoxide
GSTA2 protein results in increased metabolism of cumene hydroperoxide		 CTD PMID:3138230 PMID:15077012 PMID:15128049 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases response to substance
affects metabolic processing		 EXP GSTA3 protein results in decreased susceptibility to cumene hydroperoxide
GSTA3 protein affects the metabolism of cumene hydroperoxide		 CTD PMID:1740415 PMID:2768223 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases metabolic processing
increases metabolic processing		 ISO GSTM3 protein polymorphism results in decreased metabolism of cumene hydroperoxide
GSTM3 protein polymorphism results in increased metabolism of cumene hydroperoxide		 CTD PMID:15247628 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases metabolic processing ISO GSTP1 protein results in increased metabolism of cumene hydroperoxide CTD PMID:2747627 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects oxidation
affects metabolic processing		 ISO GSTT1 protein affects the oxidation of cumene hydroperoxide
GSTT1 protein affects the metabolism of cumene hydroperoxide		 CTD PMID:9854036 PMID:19664997 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gstt2 glutathione S-transferase theta 2 affects metabolic processing EXP GSTT2 protein affects the metabolism of cumene hydroperoxide CTD PMID:2114406 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects metabolic processing ISO GSTZ1 protein affects the metabolism of cumene hydroperoxide CTD PMID:9396740 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284 		JBrowse link
G Gusb glucuronidase, beta multiple interactions
increases secretion
decreases uptake		 ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein] CTD PMID:19135433 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO cumene hydroperoxide results in increased expression of HMOX1 mRNA CTD PMID:30547568 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO cumene hydroperoxide results in increased expression of HSPB1 protein CTD PMID:11295360 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 increases activity EXP cumene hydroperoxide results in increased activity of IDH1 protein CTD PMID:16928893 NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion		 ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of IL1B protein] CTD PMID:19135433 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide] CTD PMID:19608619 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mb myoglobin affects metabolic processing ISO MB protein mutant form affects the metabolism of cumene hydroperoxide CTD PMID:8855949 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases response to substance EXP MGST1 results in decreased susceptibility to cumene hydroperoxide CTD PMID:17306223 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with cumene hydroperoxide] results in increased activity of MPO protein CTD PMID:14972014 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases response to substance
multiple interactions
affects response to substance		 ISO NFE2L2 gene mutant form results in increased susceptibility to cumene hydroperoxide
[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]
Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide]]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide]
[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to cumene hydroperoxide		 CTD PMID:19303893 PMID:19608619 PMID:20932822 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased expression of NOS2 protein] CTD PMID:19135433 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO cumene hydroperoxide results in increased expression of NQO1 mRNA CTD PMID:30547568 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity
multiple interactions		 ISO cumene hydroperoxide results in increased activity of ODC1 protein
Iron promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]		 CTD PMID:12065085 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Ppia peptidylprolyl isomerase A decreases response to substance EXP PPIA protein results in decreased susceptibility to cumene hydroperoxide CTD PMID:17011206 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO cumene hydroperoxide results in increased expression of PRDX1 protein CTD PMID:11295360 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO cumene hydroperoxide results in increased expression of PRDX2 protein CTD PMID:11295360 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Prdx6 peroxiredoxin 6 increases expression ISO cumene hydroperoxide results in increased expression of PRDX6 protein CTD PMID:11295360 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO cumene hydroperoxide results in increased expression of PTGS2 protein
[cumene hydroperoxide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [cumene hydroperoxide results in increased expression of PTGS2 protein]		 CTD PMID:14972014 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sord sorbitol dehydrogenase increases activity EXP cumene hydroperoxide results in increased activity of SORD protein CTD PMID:16928893 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO cumene hydroperoxide results in increased expression of TGFB1 mRNA CTD PMID:8148055 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion		 ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of TNF protein] CTD PMID:19135433 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      chemical role 19495
        oxidising agent 12006
          cumene hydroperoxide 46
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    main group molecular entity 19838
                      s-block molecular entity 19698
                        hydrogen molecular entity 19679
                          hydrides 19181
                            organic hydride 18695
                              organic fundamental parent 18715
                                hydrocarbon 18458
                                  cyclic hydrocarbon 17240
                                    monocyclic hydrocarbon 6153
                                      annulene 5801
                                        aromatic annulene 5805
                                          benzene 5805
                                            alkylbenzene 3520
                                              cumene 101
                                                cumene hydroperoxide 46
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