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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:borrelidin
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Accession:CHEBI:78661 term browser browse the term
Definition:A macrolide that is isolated from several Streptomyces species and displays antibiotic, antineoplastic and antimalarial properties.
Synonyms:exact_synonym: (1R,2R)-2-[(2R,4E,6Z,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
 related_synonym: Formula=C28H43NO6;   InChI=1S/C28H43NO6/c1-17-12-18(2)14-20(4)27(32)21(16-29)8-5-6-11-25(22-9-7-10-23(22)28(33)34)35-26(31)15-24(30)19(3)13-17/h5-6,8,17-20,22-25,27,30,32H,7,9-15H2,1-4H3,(H,33,34)/b6-5+,21-8-/t17-,18+,19-,20-,22+,23+,24-,25+,27+/m0/s1;   InChIKey=OJCKRNPLOZHAOU-JTHVHBRGSA-N;   SMILES=C[C@H]1C[C@@H](C)C[C@H](C)[C@@H](O)\\C(=C/C=C/C[C@@H](OC(=O)C[C@H](O)[C@@H](C)C1)[C@@H]1CCC[C@H]1C(O)=O)C#N;   Treponemycin
 xref: CAS:7184-60-3;   KEGG:C15687
 xref_mesh: MESH:C005066
 xref: MetaCyc:CPD0-1348;   PMID:21343942;   PMID:21472957;   PMID:21678129;   PMID:22242825;   PMID:22313786;   PMID:22707527;   PMID:22822423;   PMID:22967236;   PMID:23488671;   PMID:24131731;   PMID:24155182;   PMID:24562907;   PMID:24778714;   PMID:24794971;   PMID:3680012;   Reaxys:5782155


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borrelidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases response to substance ISO BCL2 protein results in decreased susceptibility to borrelidin CTD PMID:24155182 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage		 ISO borrelidin results in increased activity of CASP3 protein
borrelidin results in increased cleavage of CASP3 protein		 CTD PMID:14563161 PMID:26271225 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO borrelidin results in increased activity of CASP8 protein CTD PMID:14563161 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO borrelidin results in increased expression of DDIT3 protein CTD PMID:21678129 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO borrelidin results in increased phosphorylation of EIF2A protein CTD PMID:26271225 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 increases activity ISO borrelidin results in increased activity of EIF2AK4 protein CTD PMID:21678129 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630 		JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases activity
multiple interactions		 ISO borrelidin results in decreased activity of TARS1 protein
borrelidin analog binds to and affects the folding of TARS1 protein; borrelidin binds to and affects the folding of TARS1 protein; borrelidin binds to and results in decreased activity of TARS1 protein		 CTD PMID:25489076 PMID:25824639 PMID:26271225 NCBI chr 2:60,368,893...60,387,715
Ensembl chr 2:60,367,796...60,387,717 		JBrowse link
G Vegfa vascular endothelial growth factor A affects splicing
multiple interactions		 ISO borrelidin affects the splicing of VEGFA mRNA; borrelidin analog affects the splicing of VEGFA mRNA
borrelidin analog inhibits the reaction [WBP4 protein affects the splicing of VEGFA mRNA]		 CTD PMID:22822423 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wbp4 WW domain binding protein 4 affects binding
multiple interactions		 ISO borrelidin analog binds to WBP4 protein; borrelidin binds to WBP4 protein
borrelidin analog inhibits the reaction [WBP4 protein affects the splicing of VEGFA mRNA]		 CTD PMID:22822423 NCBI chr15:54,862,700...54,890,668
Ensembl chr15:54,862,843...54,890,647 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        antimicrobial agent 18274
          borrelidin 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            heteroorganic entity 19549
                              organochalcogen compound 19309
                                organooxygen compound 19204
                                  ester 17480
                                    carboxylic ester 16763
                                      lactone 13305
                                        macrocyclic lactone 7584
                                          macrolide 7532
                                            borrelidin 9
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