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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aflatoxin Q1
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Accession:CHEBI:78582 term browser browse the term
Definition:A member of the class of aflatoxins that is aflatoxin B1 in which the hydrogen at the pro-3S position is replaced by a hydroxy group.
Synonyms:exact_synonym: (3S,6aR,9aS)-3-hydroxy-4-methoxy-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene-1,11-dione
 related_synonym: AFQ1;   Formula=C17H12O7;   InChI=1S/C17H12O7/c1-21-9-5-10-11(6-2-3-22-17(6)23-10)15-14(9)12-7(18)4-8(19)13(12)16(20)24-15/h2-3,5-7,17-18H,4H2,1H3/t6-,7-,17+/m0/s1;   InChIKey=GYNOTJLCULOEIM-XKRJZGAWSA-N;   SMILES=COc1cc2O[C@H]3OC=C[C@H]3c2c2oc(=O)c3C(=O)C[C@H](O)c3c12
 xref: CAS:52819-96-2;   HMDB:HMDB0030753;   KEGG:C19585;   KNApSAcK:C00023624
 xref_mesh: MESH:C033759
 xref: PMID:1185319;   PMID:1643250;   PMID:3099349;   PMID:3116726;   PMID:3141079;   PMID:4081304;   PMID:6622820;   PMID:6712219;   PMID:6766512;   PMID:7987484;   PMID:9385444;   Reaxys:8866397


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aflatoxin Q1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin Q1 CTD PMID:20707407 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gnmt glycine N-methyltransferase decreases secretion ISO GNMT results in decreased secretion of aflatoxin Q1 CTD PMID:19146867 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        aetiopathogenetic role 19217
          carcinogenic agent 18525
            aflatoxin Q1 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heteropentacyclic compound 13566
                                      cyclopentafurofurochromene 11154
                                        aflatoxin 11154
                                          aflatoxin B1 11154
                                            aflatoxin Q1 2
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