adenylate cyclase agonist - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	adenylate cyclase agonist	go back to main search page
Accession:	CHEBI:78548	browse the term
Definition:	Any agonist of one or more of the isoforms of adenylate cyclase (EC 4.6.1.1).
Synonyms:	related_synonym:	adenylate cyclase agonists; adenylyl cyclase agonist; adenylyl cyclase agonists

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Rat (350) Mouse (347) Human (374) Chinchilla (0) Bonobo (0) Dog (4) Squirrel (0) Pig (4) Green Monkey (0) Naked Mole-rat (0) All
Genes (350)

1,9-dideoxyforskolin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

decreases activity

1,9-dideoxyforskolin results in decreased activity of ABCB1A protein

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

decreases activity

1,9-dideoxyforskolin results in decreased activity of ABCB1B protein

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily B member 4

decreases activity

1,9-dideoxyforskolin results in decreased activity of ABCB4 protein

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

colforsin daropate hydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

Colforsin promotes the reaction [Diethylhexyl Phthalate results in decreased expression of ABCA1 mRNA]

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases expression

N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of ABCB1 mRNA]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 4

multiple interactions
decreases expression

Colforsin inhibits the reaction [Doxorubicin results in increased expression of ABCB4 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in decreased expression of ABCB4 mRNA]

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 2

increases expression

Colforsin results in increased expression of ABCC2 mRNA; Colforsin results in increased expression of ABCC2 protein

PMID:19580841 PMID:26049102

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 4

decreases expression
multiple interactions

Colforsin results in decreased expression of ABCC4 mRNA
Valproic Acid inhibits the reaction [Colforsin results in decreased expression of ABCC4 mRNA]

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily G member 2

increases expression
multiple interactions

Colforsin results in increased expression of ABCG2 mRNA
Colforsin inhibits the reaction [anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]]

PMID:19580841 PMID:30610963

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

acetyl-CoA carboxylase alpha

increases phosphorylation

Colforsin results in increased phosphorylation of ACACA protein

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acetylcholinesterase

increases activity
increases expression

Colforsin results in increased activity of ACHE protein; Colforsin results in increased activity of ACHE protein alternative form
Colforsin results in increased expression of ACHE mRNA

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acyl-CoA synthetase long-chain family member 3

increases expression

Colforsin results in increased expression of ACSL3 mRNA

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

Colforsin results in decreased expression of ACTA2 protein
Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

PMID:21603974 PMID:27590029

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

ADAM metallopeptidase domain 12

decreases expression

Colforsin results in decreased expression of ADAM12 mRNA

PMID:15313392 PMID:15967414

NCBI chr 1:188,686,984...189,014,206
Ensembl chr 1:188,686,989...189,020,667

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

decreases expression

Colforsin results in decreased expression of ADAMTS1 mRNA

PMID:15313392 PMID:15967414

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

adenylate cyclase 5

multiple interactions

ADCY5 protein results in increased susceptibility to [Colforsin co-treated with Quinpirole]

NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974

G

adenylate cyclase 6

affects response to substance

ADCY6 protein affects the susceptibility to Colforsin

NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754

G

adenylate cyclase 9

multiple interactions
increases activity

[Colforsin co-treated with Miconazole] results in increased activity of ADCY9 protein
Colforsin results in increased activity of ADCY9 protein

NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066

G

adrenomedullin

multiple interactions
increases expression

cobaltous chloride inhibits the reaction [Valproic Acid inhibits the reaction [Colforsin results in increased expression of ADM mRNA]]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of ADM mRNA]

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adrenoceptor alpha 1A

multiple interactions

[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

adrenoceptor alpha 2C

multiple interactions
increases expression
affects localization

AKAP13 protein modified form affects the reaction [Colforsin affects the localization of ADRA2C protein]; AKAP13 protein modified form affects the reaction [Colforsin results in increased expression of ADRA2C mRNA]

NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846

G

adrenoceptor beta 1

affects response to substance
multiple interactions

ADRB1 protein polymorphism affects the susceptibility to Colforsin
[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]

PMID:14502278 PMID:19419905

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

multiple interactions
increases phosphorylation
increases expression

[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]
Colforsin results in increased phosphorylation of ADRB2 protein
Colforsin results in increased expression of ADRB2 mRNA

PMID:14722251 PMID:19419905 PMID:24705868

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

adrenoceptor beta 3

decreases expression

Colforsin results in decreased expression of ADRB3 mRNA

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

aryl hydrocarbon receptor

multiple interactions
affects localization

[Colforsin results in increased activity of AHR protein] which results in increased expression of CXCL8 mRNA; [Colforsin results in increased activity of AHR protein] which results in increased expression of CXCL8 protein; [Colforsin results in increased activity of AHR protein] which results in increased secretion of CXCL8 protein; Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]]; PDE2A protein inhibits the reaction [Colforsin affects the localization of AHR protein]
AHR protein inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA]

PMID:15972329 PMID:17329248 PMID:17823304 PMID:23291558

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

A-kinase anchoring protein 13

multiple interactions

AKAP13 protein modified form affects the reaction [Colforsin affects the localization of ADRA2C protein]; AKAP13 protein modified form affects the reaction [Colforsin results in increased expression of ADRA2C mRNA]; AKAP13 protein modified form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]

NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646

G

aldo-keto reductase family 1, member C3

decreases expression

Colforsin results in decreased expression of AKR1C3 mRNA

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

AKT serine/threonine kinase 1

multiple interactions

Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

multiple interactions

Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein]

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

AKT serine/threonine kinase 3

multiple interactions

Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein]

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

albumin

multiple interactions

Colforsin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

alkaline phosphatase, intestinal

multiple interactions

Colforsin inhibits the reaction [Methotrexate results in increased activity of ALPI protein]

NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877

G

alkaline phosphatase, placental

increases expression
multiple interactions

Colforsin results in increased expression of ALPP mRNA
[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of ALPP mRNA; Chlorpromazine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Desipramine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]

NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606

G

amine oxidase, copper containing 1

increases activity

Colforsin results in increased activity of AOC1 protein

NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840

G

amyloid beta precursor protein binding protein 2

decreases expression

Colforsin results in decreased expression of APPBP2 mRNA

NCBI chr10:70,057,774...70,099,877
Ensembl chr10:70,057,774...70,099,835

G

androgen receptor

multiple interactions
increases expression

AR protein affects the reaction [Colforsin results in decreased expression of SESN1 protein]; AR protein promotes the reaction [Colforsin results in increased expression of HMGCR protein]; AR protein promotes the reaction [Colforsin results in increased expression of INSIG1 protein]; AR protein promotes the reaction [Colforsin results in increased expression of KLK2 protein]; AR protein promotes the reaction [Colforsin results in increased expression of KLK3 protein]; Colforsin promotes the reaction [Metribolone results in increased activity of AR protein]
Colforsin results in increased expression of AR protein

PMID:16751804 PMID:17219378

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

amphiregulin

increases expression
multiple interactions

Colforsin results in increased expression of AREG mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of AREG mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of AREG protein]

PMID:15284208 PMID:15313392 PMID:15474502 PMID:15967414 PMID:20378682

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

arrestin, beta 1

multiple interactions

Colforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

ataxin 3

decreases expression

Colforsin results in decreased expression of ATXN3 mRNA

NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902

G

BCL2, apoptosis regulator

multiple interactions

[S-(1,2-dichlorovinyl)cysteine co-treated with Colforsin] results in decreased expression of BCL2 mRNA; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Colforsin results in increased expression of BCL2 mRNA]

PMID:36336211 PMID:37544576

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

multiple interactions
increases expression

1-bromopropane inhibits the reaction [Colforsin results in increased expression of BDNF mRNA]; 1-bromopropane inhibits the reaction [Colforsin results in increased expression of BDNF protein]
Colforsin results in increased expression of BDNF mRNA; Colforsin results in increased expression of BDNF protein
Colforsin inhibits the reaction [Caffeine results in decreased expression of BDNF mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of BDNF protein]

PMID:19189864 PMID:35917217

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

basic helix-loop-helix ARNT like 1

increases expression

Colforsin results in increased expression of BMAL1 mRNA

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

bone morphogenetic protein 6

multiple interactions

BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of HSD3B1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of OXT mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]; FST protein inhibits the reaction [BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

complement C4A

multiple interactions

[Colforsin co-treated with Diethylhexyl Phthalate] affects the expression of C4A mRNA

NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080

G

calcium voltage-gated channel subunit alpha1 G

multiple interactions

Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1G protein]; Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1G protein]

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

G

calcium voltage-gated channel subunit alpha1 H

multiple interactions

Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein]; Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein]

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

calcium voltage-gated channel subunit alpha1 I

multiple interactions

Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein]; Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein]

NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688

G

calcitonin receptor like receptor

multiple interactions

Colforsin inhibits the reaction [EDN1 protein results in increased expression of CALCRL mRNA]

NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910

G

calcium/calmodulin-dependent protein kinase kinase 2

increases expression

Colforsin results in increased expression of CAMKK2 mRNA

NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279

G

calcium/calmodulin dependent serine protein kinase

multiple interactions
increases phosphorylation

Colforsin promotes the reaction [CASK protein modified form binds to TBR1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CASK protein]

NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694

G

caspase 1

increases activity

Colforsin results in increased activity of CASP1 mRNA; Colforsin results in increased activity of CASP1 protein

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases activity
multiple interactions

Colforsin results in increased activity of CASP3 protein
Colforsin inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]
KT 5720 inhibits the reaction [Colforsin results in increased activity of CASP3 protein]
Colforsin inhibits the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]

PMID:16396944 PMID:20131233 PMID:21745194 PMID:31278978

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

Colforsin inhibits the reaction [mancozeb results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 5

multiple interactions

Colforsin inhibits the reaction [Reactive Oxygen Species results in increased expression of CCL5 mRNA]; Colforsin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

CD55 molecule (Cromer blood group)

multiple interactions
increases expression

3',4'-dimethoxy-alpha-naphthoflavone inhibits the reaction [Colforsin results in increased expression of CD55 mRNA]

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

G

cell division cycle 6

increases expression

Colforsin results in increased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cadherin 1

affects activity
increases expression

Colforsin affects the activity of CDH1 protein
Colforsin results in increased expression of CDH1 protein

PMID:10413674 PMID:30983542

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

CMT1A duplicated region transcript 4

multiple interactions

[Colforsin co-treated with Diethylhexyl Phthalate] affects the expression of CDRT4 mRNA

NCBI chr10:47,625,470...47,657,493
Ensembl chr10:47,625,470...47,657,493

G

CCAAT/enhancer binding protein alpha

multiple interactions
increases expression

Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPA mRNA]
Colforsin results in increased expression of CEBPA protein
Colforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CEBPA protein]

PMID:17407152 PMID:21832167

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein beta

increases expression
multiple interactions

Colforsin results in increased expression of CEBPB mRNA
[Atrazine co-treated with Colforsin] results in increased expression of CEBPB protein

PMID:14684744 PMID:25253736

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

CF transmembrane conductance regulator

affects localization
increases activity
multiple interactions

Colforsin affects the localization of CFTR protein
Colforsin analog results in increased activity of CFTR protein mutant form; Colforsin results in increased activity of CFTR protein; Colforsin results in increased activity of CFTR protein mutant form
3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Colforsin results in increased activity of CFTR protein]; 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; 5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; 6-hydroxy-10-chlorobenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; [1-Methyl-3-isobutylxanthine co-treated with Colforsin] results in increased activity of CFTR protein; [1-Methyl-3-isobutylxanthine co-treated with Colforsin] results in increased activity of CFTR protein mutant form; [5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride co-treated with Colforsin] results in increased activity of CFTR protein mutant form; [[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CFTR protein; [Colforsin co-treated with Genistein] results in increased activity of CFTR protein; [Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; [Colforsin co-treated with NS 004] results in increased activity of CFTR protein mutant form; [ivacaftor co-treated with Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; [ivacaftor co-treated with Colforsin] results in increased activity of CFTR protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]; Colforsin binds to and results in decreased activity of CFTR protein; Colforsin promotes the reaction [CFTR protein affects the export of Chlorides]; Colforsin promotes the reaction [Nimodipine results in increased activity of CFTR protein]; Colforsin results in increased phosphorylation of and results in increased activity of CFTR protein; fenamic acid inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; fenamic acid inhibits the reaction [Colforsin results in increased activity of CFTR protein]; geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Glyburide inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; Glyburide inhibits the reaction [Colforsin results in increased activity of CFTR protein]; miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CFTR protein]; Ozone inhibits the reaction [Colforsin results in increased activity of CFTR protein]; Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; VRT 532 analog promotes the reaction [Colforsin results in increased activity of CFTR protein mutant form]; VRT 532 promotes the reaction [Colforsin results in increased activity of CFTR protein mutant form]
[1-Methyl-3-isobutylxanthine co-treated with Colforsin] results in increased activity of CFTR protein; Colforsin promotes the reaction [Nimodipine results in increased activity of CFTR protein]
[Colforsin co-treated with Genistein] results in increased activity of CFTR protein; AICA ribonucleotide inhibits the reaction [Colforsin results in increased activity of CFTR protein]

PMID:12519745 PMID:12914781 PMID:14502435 PMID:14967738 PMID:15163550 More...

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

glycoprotein hormones, alpha polypeptide

increases secretion
increases expression
multiple interactions

Colforsin results in increased secretion of CGA protein
Colforsin results in increased expression of CGA protein
Colforsin results in increased expression of CGA mRNA
Colforsin promotes the reaction [CGA protein results in increased abundance of Cyclic AMP]; perfluorobutanesulfonic acid inhibits the reaction [Colforsin results in increased expression of CGA protein]; perfluorooctane sulfonic acid inhibits the reaction [Colforsin results in increased expression of CGA protein]
Colforsin inhibits the reaction [ESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]]

PMID:8404651 PMID:16503475 PMID:20378682 PMID:33144174

NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191

G

cell death-inducing DFFA-like effector c

increases expression

Colforsin results in increased expression of CIDEC protein

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

G

cannabinoid receptor 1

multiple interactions
increases activity
affects response to substance

(1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; (4-ethyl-1-naphthalenyl)(1-(5-fluoropentyl)-1H-indol-3-yl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(2-cyclohexylethyl)-3-(2-methoxyphenylacetyl)indole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyl-3-(1-naphthoyl)indole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 2-(4-methoxyphenyl)-1-(1-pentyl-indol-3-yl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-((adamantan-1-yl)carbonyl)-1-pentylindole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-((adamantan-1-yl)carbonyl)-1-pentylindole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased activity of CNR1 protein]; [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [Dronabinol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of CNR1 mRNA; AM 6527 analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; AM 6527 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; CNR1 protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased activity of CNR1 protein]]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [Colforsin results in increased activity of CNR1 protein]; Dronabinol inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Dronabinol inhibits the reaction [Colforsin results in increased activity of CNR1 protein]; FDU-PB-22 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; FUB-PB-22 compound inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Indazoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Indoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(1-adamantyl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(1-adamantyl)-1-pentylindazole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; napht-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; THJ-2201 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; XLR-11 analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; XLR-11 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]
CNR1 protein affects the susceptibility to Colforsin

PMID:27429655 PMID:27527584 PMID:28861508 PMID:31154070

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

cannabinoid receptor 2

multiple interactions
increases activity
affects response to substance

(1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; (4-ethyl-1-naphthalenyl)(1-(5-fluoropentyl)-1H-indol-3-yl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(2-cyclohexylethyl)-3-(2-methoxyphenylacetyl)indole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyl-3-(1-naphthoyl)indole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 2-(4-methoxyphenyl)-1-(1-pentyl-indol-3-yl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-((adamantan-1-yl)carbonyl)-1-pentylindole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-((adamantan-1-yl)carbonyl)-1-pentylindole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased activity of CNR2 protein]; [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [Dronabinol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of CNR2 mRNA; [virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; AM 6527 analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; AM 6527 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; CNR2 protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; Dronabinol inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Dronabinol inhibits the reaction [Colforsin results in increased activity of CNR2 protein]; FDU-PB-22 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; FUB-PB-22 compound inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Indazoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Indoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(1-adamantyl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(1-adamantyl)-1-pentylindazole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; napht-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; Pertussis Toxin inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; SR 144528 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; SR 144528 inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; THJ-2201 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; XLR-11 analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; XLR-11 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]
CNR2 protein affects the susceptibility to Colforsin

PMID:17558435 PMID:27429655 PMID:27527584 PMID:28861508 PMID:30504240 More...

NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548

G

cAMP responsive element binding protein 1

increases activity
increases expression
increases phosphorylation
multiple interactions

Colforsin results in increased activity of CREB1 protein
Colforsin results in increased expression of CREB1 mRNA; Colforsin results in increased expression of CREB1 protein modified form
Colforsin results in increased phosphorylation of CREB1 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; Colforsin inhibits the reaction [Caffeine results in decreased expression of CREB1 mRNA]; Colforsin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CREB1 protein modified form]; Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; Okadaic Acid inhibits the reaction [Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; Resveratrol inhibits the reaction [Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]]; Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; SIRT1 protein inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; SIRT1 protein mutant form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]
AKAP13 protein modified form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; anandamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; Colforsin inhibits the reaction [anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]]; Colforsin results in increased phosphorylation of and results in increased activity of CREB1 protein
[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of CREB1 protein; alisol B inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of CREB1 protein]; oxophenylarsine inhibits the reaction [Colforsin results in increased activity of CREB1 protein]; oxophenylarsine inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; RTKI cpd inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]

PMID:10908723 PMID:11113530 PMID:15522277 PMID:17141199 PMID:17322281 More...

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

CREB binding protein

multiple interactions

Colforsin promotes the reaction [GCM1 protein binds to CREBBP protein]; CREBBP protein affects the reaction [Colforsin results in increased activity of GCM1 protein]

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

cAMP responsive element modulator

increases expression

Colforsin results in increased expression of CREM mRNA; Colforsin results in increased expression of CREM mRNA alternative form; Colforsin results in increased expression of CREM protein

PMID:8810303 PMID:12791704

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

corticotropin releasing hormone

multiple interactions
increases secretion

CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]; CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]; CRH protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; CRH protein inhibits the reaction [Colforsin results in increased chemical synthesis of Testosterone]
Colforsin results in increased secretion of CRH protein
[perfluorooctane sulfonic acid co-treated with Colforsin] results in increased expression of CRH mRNA

PMID:2153673 PMID:33144174

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cardiolipin synthase 1

increases expression

Colforsin results in increased expression of CRLS1 mRNA

NCBI chr 3:120,119,822...120,138,674
Ensembl chr 3:120,119,852...120,138,655

G

crystallin, alpha B

multiple interactions

Colforsin inhibits the reaction [arsenite results in increased expression of CRYAB protein]

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

cytochrome P450, family 11, subfamily a, polypeptide 1

affects expression
multiple interactions
increases expression

Colforsin affects the expression of CYP11A1 mRNA
[Colforsin co-treated with Zearalenone] results in increased expression of CYP11A1 mRNA
Colforsin results in increased expression of CYP11A1 mRNA
[Colforsin co-treated with triptolide] results in decreased expression of CYP11A1 mRNA; Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; Valproic Acid affects the reaction [Colforsin affects the expression of CYP11A1 mRNA]
[Atrazine co-treated with Colforsin] results in increased expression of CYP11A1 mRNA; RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 protein]

PMID:14691014 PMID:16935330 PMID:17080404 PMID:18936084 PMID:20726872 More...

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 11, subfamily b, polypeptide 2

increases activity
multiple interactions
increases expression

Colforsin results in increased activity of CYP11B1 protein
[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with Colforsin] affects the expression of CYP11B1 mRNA; [Colforsin co-treated with triptolide] results in decreased expression of CYP11B1 mRNA; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B1 mRNA]

PMID:12525251 PMID:17080404 PMID:19164467 PMID:19900470 PMID:21256172 More...

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 11, subfamily b, polypeptide 3

increases expression
multiple interactions

Colforsin results in increased expression of CYP11B2 mRNA
[1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with Colforsin] affects the expression of CYP11B2 mRNA; [Colforsin co-treated with triptolide] results in decreased expression of CYP11B2 mRNA; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B2 mRNA]; Ketoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA]

PMID:16935330 PMID:17080404 PMID:19164467 PMID:19900470 PMID:21256172 More...

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression
multiple interactions

Colforsin results in increased expression of CYP17A1 mRNA
[Colforsin co-treated with triptolide] results in decreased expression of CYP17A1 mRNA; Apigenin inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; Ketoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; TGFB1 protein inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]

PMID:15625562 PMID:15886251 PMID:16935330 PMID:17080404 PMID:20726872 More...

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases activity
increases expression
multiple interactions

Colforsin results in increased activity of CYP19A1 protein
Colforsin results in increased expression of CYP19A1 mRNA
Colforsin results in increased expression of CYP19A1 mRNA; Colforsin results in increased expression of CYP19A1 protein
RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; [Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA; [Colforsin results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol; [Colforsin results in increased activity of CYP19A1 protein] which results in increased abundance of Testosterone; Alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]; Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; Atrazine inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; mono-(2-ethylhexyl)phthalate inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; NR4A1 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; NR4A2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; NR4A3 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased activity of CYP19A1 protein]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; ZNF461 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]

PMID:14691014 PMID:16357189 PMID:16935330 PMID:16996190 PMID:17080404 More...

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
affects expression

Colforsin inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]
Colforsin affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
Colforsin affects the expression of CYP1A1 mRNA
Valproic Acid affects the reaction [Colforsin affects the expression of CYP1A1 mRNA]

PMID:1849469 PMID:15710352 PMID:20726872

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

Colforsin affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]
Colforsin inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]

PMID:1849469 PMID:15710352

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

Colforsin results in increased expression of CYP1B1 mRNA; Colforsin results in increased expression of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

[S-(1,2-dichlorovinyl)cysteine co-treated with Colforsin] results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
multiple interactions

Colforsin results in increased expression of CYP3A4 mRNA
[S-(1,2-dichlorovinyl)cysteine co-treated with Colforsin] results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dopamine beta-hydroxylase

multiple interactions
increases expression

Colforsin inhibits the reaction [Atrazine results in decreased expression of DBH protein]; Colforsin inhibits the reaction [Simazine results in decreased expression of DBH protein]
Colforsin results in increased expression of DBH protein

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

G

dopachrome tautomerase

increases expression

Colforsin results in increased expression of DCT mRNA; Colforsin results in increased expression of DCT protein

PMID:17460731 PMID:28601556

NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836

G

iodothyronine deiodinase 2

increases activity
multiple interactions
increases expression

Colforsin results in increased activity of DIO2 protein
Buthionine Sulfoximine inhibits the reaction [Colforsin results in increased activity of DIO2 protein]; Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]; Hydrogen Peroxide inhibits the reaction [Colforsin results in increased expression of DIO2 mRNA]; Sodium Selenite inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]]; U 0126 inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]]; U 0126 inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased expression of DIO2 mRNA]]

PMID:18420745 PMID:19036883

NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809

G

iodothyronine deiodinase 3

multiple interactions

Colforsin promotes the reaction [Hydrogen Peroxide results in increased expression of DIO3 mRNA]

NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660

G

dynamin 1-like

multiple interactions
decreases expression

PINK1 protein affects the reaction [Colforsin results in decreased expression of DNM1L protein]

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

dopamine receptor D2

multiple interactions

[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; epigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dynein light chain LC8-type 2

increases expression

Colforsin results in increased expression of DYNLL2 mRNA

NCBI chr10:72,767,035...72,785,824
Ensembl chr10:72,767,035...72,785,805

G

endothelin 1

multiple interactions

Colforsin inhibits the reaction [EDN1 protein results in increased expression of CALCRL mRNA]; Colforsin inhibits the reaction [EDN1 protein results in increased expression of ICAM2 mRNA]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

epidermal growth factor

multiple interactions

[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

early growth response 1

decreases expression
multiple interactions

Colforsin results in decreased expression of EGR1 mRNA; Colforsin results in decreased expression of EGR1 protein
Colforsin inhibits the reaction [Ethanol results in increased expression of EGR1 mRNA]; Colforsin inhibits the reaction [Ethanol results in increased expression of EGR1 protein]; Ethanol inhibits the reaction [Colforsin results in decreased expression of EGR1 mRNA]; Ethanol inhibits the reaction [Colforsin results in decreased expression of EGR1 protein]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2B subunit epsilon

increases expression

Colforsin results in increased expression of EIF2B5 mRNA

NCBI chr11:80,394,433...80,404,468
Ensembl chr11:80,394,433...80,404,419

G

eukaryotic translation initiation factor 5A2

decreases expression

Colforsin results in decreased expression of EIF5A2 mRNA

NCBI chr 2:111,728,587...111,746,087
Ensembl chr 2:111,729,323...111,746,087

G

epoxide hydrolase 1

affects expression
multiple interactions

Colforsin affects the expression of EPHX1 mRNA
Valproic Acid affects the reaction [Colforsin affects the expression of EPHX1 mRNA]

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

EGFR pathway substrate 8, signaling adaptor

decreases expression

Colforsin results in decreased expression of EPS8 mRNA

PMID:15313392 PMID:15967414

NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873

G

epiregulin

increases expression

Colforsin results in increased expression of EREG mRNA

PMID:15313392 PMID:15474502 PMID:15967414 PMID:20378682

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

endogenous retrovirus group FRD member 1, envelope

multiple interactions
increases expression
increases secretion

[Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [Colforsin results in increased expression of ERVFRD-1 mRNA]; Colforsin promotes the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the reaction [Colforsin results in increased expression of ERVFRD-1 mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of ERVFRD-1 mRNA]
Colforsin results in increased expression of ERVFRD-1 mRNA; Colforsin results in increased expression of ERVFRD-1 protein
Colforsin results in increased secretion of ERVFRD-1 protein

PMID:24361490 PMID:29679653 PMID:31278978 PMID:33144174 PMID:35908931 More...

NCBI chr12:22,151,211...22,158,264
Ensembl chr12:22,151,211...22,158,264

G

estrogen receptor 1

decreases expression

Colforsin results in decreased expression of ESR1 mRNA

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
decreases expression

Colforsin inhibits the reaction [ESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]]
Colforsin results in decreased expression of ESR2 mRNA

PMID:20378682 PMID:31278978

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

estrogen related receptor, alpha

increases expression

Colforsin results in increased expression of ESRRA mRNA; Colforsin results in increased expression of ESRRA protein

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

ecotropic viral integration site 5

increases expression

Colforsin results in increased expression of EVI5 mRNA

NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678

G

coagulation factor II, thrombin

multiple interactions

Colforsin inhibits the reaction [F2 protein results in increased uptake of Manganese]

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor II (thrombin) receptor

multiple interactions

[C186 65 binds to and results in increased activity of F2R protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

G

F2R like thrombin or trypsin receptor 3

multiple interactions

[GYPGKF-NH(2) binds to and results in increased activity of F2RL3 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]

NCBI chr16:17,117,441...17,119,434
Ensembl chr16:17,117,441...17,119,472

G

fatty acid desaturase 1

increases expression

Colforsin results in increased expression of FADS1 mRNA

NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734

G

fatty acid synthase

multiple interactions

[Colforsin co-treated with 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime] results in increased expression of FASN mRNA; [Colforsin co-treated with Leflunomide] results in increased expression of FASN mRNA; [Colforsin co-treated with teriflunomide] results in increased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

ferredoxin 1

multiple interactions
increases expression

ferulic acid analog promotes the reaction [Colforsin results in increased expression of FDX1 mRNA]

NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414

G

fibroblast growth factor 10

multiple interactions

Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK1 protein]; Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK3 protein]

PMID:12533312 PMID:14975937

NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866

G

fibroblast growth factor 2

increases expression

Colforsin results in increased expression of FGF2 mRNA; Colforsin results in increased expression of FGF2 protein

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 5

decreases expression

Colforsin results in decreased expression of FGF5 mRNA

NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997

G

fibroblast growth factor 8

increases activity

Colforsin results in increased activity of FGF8 protein

NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359

G

fibroblast growth factor 9

multiple interactions

FGF9 protein inhibits the reaction [Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]; FGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]]

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

Fibroblast growth factor receptor 1

increases expression

Colforsin results in increased expression of FGFR1 mRNA

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

fibroblast growth factor receptor 2

increases expression

Colforsin results in increased expression of FGFR2 mRNA

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

FKBP prolyl isomerase 5

multiple interactions

Colforsin promotes the reaction [Dexamethasone results in increased expression of FKBP5 mRNA]

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

G

Fms related receptor tyrosine kinase 1

increases expression

Colforsin results in increased expression of FLT1 mRNA

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Colforsin results in increased expression of FOS protein
Dexamethasone inhibits the reaction [Colforsin results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Colforsin results in increased expression of FOSB mRNA; Colforsin results in increased expression of FOSB protein

PMID:11113530 PMID:17324382

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

follicle stimulating hormone subunit beta

increases expression

Colforsin results in increased expression of FSHB mRNA; Colforsin results in increased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

follistatin

multiple interactions

FST protein inhibits the reaction [BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]; FST protein inhibits the reaction [INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

[Dexamethasone co-treated with Colforsin] results in increased expression of G6PC1 mRNA
Colforsin inhibits the reaction [Leflunomide results in increased expression of G6PC1 mRNA]; Colforsin inhibits the reaction [teriflunomide results in increased expression of G6PC1 mRNA]

PMID:18972406 PMID:30364229

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

gamma-aminobutyric acid type A receptor subunit alpha 1

increases expression

Colforsin results in increased expression of GABRA1

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit alpha6

decreases expression

Colforsin results in decreased expression of GABRA6

NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769

G

growth arrest specific 6

decreases expression

Colforsin results in decreased expression of GAS6 mRNA

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

gastrin

multiple interactions
increases secretion

Calcium promotes the reaction [Colforsin results in increased secretion of GAST protein]; Nitrendipine inhibits the reaction [Colforsin results in increased secretion of GAST protein]
2',5'-dideoxyadenosine inhibits the reaction [Colforsin results in increased secretion of GAST protein]

PMID:9277405 PMID:19208342

NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496

G

glucagon

multiple interactions
increases secretion

Colforsin promotes the reaction [Pyruvic Acid results in increased secretion of GCG protein]
Colforsin results in increased secretion of GCG protein

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glial cells missing transcription factor 1

multiple interactions
increases expression
decreases expression

Colforsin promotes the reaction [GCM1 protein binds to CREBBP protein]; Colforsin results in increased acetylation of and results in increased activity of GCM1 protein; CREBBP protein affects the reaction [Colforsin results in increased activity of GCM1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased activity of GCM1 protein]; trichostatin A promotes the reaction [Colforsin results in increased acetylation of and results in increased activity of GCM1 protein]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of GCM1 mRNA]
Colforsin results in decreased expression of GCM1 mRNA

PMID:16166624 PMID:31278978 PMID:37385477

NCBI chr 8:78,925,687...78,938,924
Ensembl chr 8:78,925,687...78,938,924

G

glial fibrillary acidic protein

decreases expression

Colforsin results in decreased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

growth hormone 1

increases secretion
multiple interactions

Colforsin results in increased secretion of GH1 protein
GH1 protein promotes the reaction [Colforsin results in increased metabolism of Lipids]

PMID:14981226 PMID:19952226

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

gap junction protein, alpha 1

multiple interactions
decreases expression

Valproic Acid inhibits the reaction [Colforsin results in decreased expression of GJA1 mRNA]

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

GLI family zinc finger 1

decreases expression

Colforsin results in decreased expression of GLI1 mRNA; Colforsin results in decreased expression of GLI1 protein

NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251

G

GLI family zinc finger 2

multiple interactions

Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of GLI2 mRNA]

NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574

G

G protein subunit alpha i3

increases expression

Colforsin results in increased expression of GNAI3 mRNA

NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742

G

G protein-coupled bile acid receptor 1

multiple interactions

[Colforsin binds to and results in increased activity of GPBAR1 protein] which results in increased abundance of Cyclic AMP; Colforsin binds to and results in increased activity of GPBAR1 protein

NCBI chr 9:75,860,758...75,863,260
Ensembl chr 9:75,860,677...75,863,168

G

glutamate ionotropic receptor NMDA type subunit 1

increases phosphorylation
multiple interactions

Colforsin results in increased phosphorylation of GRIN1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of GRIN1 protein]

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions
increases expression

N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of GRIN2B protein]
Colforsin results in increased expression of GRIN2B mRNA; Colforsin results in increased expression of GRIN2B protein

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glycogen synthase kinase 3 beta

multiple interactions

Colforsin results in increased phosphorylation of and results in decreased activity of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

hepcidin antimicrobial peptide

affects expression
multiple interactions

Colforsin affects the expression of HAMP mRNA
Colforsin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

hydroxycarboxylic acid receptor 2

multiple interactions

[3-Hydroxybutyric Acid results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Niacin results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Nicotinic Acids binds to and results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Pertussis Toxin inhibits the reaction [[Nicotinic Acids binds to and results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]

PMID:17124637 PMID:19223991

NCBI chr12:32,726,252...32,728,238
Ensembl chr12:32,726,184...32,728,504

G

hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions

Colforsin results in increased expression of HIF1A protein
[cobaltous chloride co-treated with Valproic Acid co-treated with Colforsin] results in increased expression of HIF1A protein; Valproic Acid inhibits the reaction [Colforsin results in increased expression of HIF1A protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hexokinase 2

increases expression
multiple interactions

Colforsin results in increased expression of HK2 mRNA
cobaltous chloride inhibits the reaction [Valproic Acid inhibits the reaction [Colforsin results in increased expression of HK2 mRNA]]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of HK2 mRNA]

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

3-hydroxy-3-methylglutaryl-CoA reductase

affects expression
multiple interactions
increases expression

Colforsin affects the expression of HMGCR mRNA
[Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA; [Colforsin co-treated with triptolide] results in decreased expression of HMGCR mRNA; AR protein promotes the reaction [Colforsin results in increased expression of HMGCR protein]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Valproic Acid affects the reaction [Colforsin affects the expression of HMGCR mRNA]
Colforsin results in increased expression of HMGCR mRNA

PMID:16751804 PMID:16935330 PMID:20726872 PMID:30825513 PMID:31557376

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

multiple interactions

Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

heme oxygenase 1

increases expression
multiple interactions

Colforsin results in increased expression of HMOX1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of HMOX1 protein]
Colforsin results in increased expression of HMOX1 mRNA; Colforsin results in increased expression of HMOX1 protein

PMID:15179140 PMID:16439612 PMID:19483313

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein A1

multiple interactions

HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of RUNX1 exon]; HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of SNAP25 exon]

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

G

heterogeneous nuclear ribonucleoprotein K

multiple interactions

Colforsin promotes the reaction [HNRNPK protein binds to SNAP25 exon]

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

histamine receptor H 2

multiple interactions

Dimaprit inhibits the reaction [HRH2 protein promotes the reaction [Colforsin results in increased abundance of Cyclic AMP]]; HRH2 protein promotes the reaction [Colforsin results in increased abundance of Cyclic AMP]

NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631

G

histamine receptor H3

multiple interactions

[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; ciproxifan inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; Pertussis Toxin inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; thioperamide inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]

NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642

G

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions
increases expression

Colforsin inhibits the reaction [1,7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [1,7-dimethylxanthine results in decreased expression of HSD11B2 mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]; Colforsin inhibits the reaction [Ethanol results in decreased expression of HSD11B2 mRNA]; Colforsin inhibits the reaction [Ethanol results in decreased expression of HSD11B2 protein]; Ethanol inhibits the reaction [Colforsin results in increased expression of HSD11B2 mRNA]; Ethanol inhibits the reaction [Colforsin results in increased expression of HSD11B2 protein]
Colforsin results in increased expression of HSD11B2 mRNA; Colforsin results in increased expression of HSD11B2 protein

PMID:22701600 PMID:24361490 PMID:29802914 PMID:33144174

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

hydroxysteroid (17-beta) dehydrogenase 1

affects expression
multiple interactions
increases expression

Colforsin affects the expression of HSD17B1 mRNA
[Colforsin co-treated with Aminoglutethimide] results in decreased expression of HSD17B1 mRNA; [Colforsin co-treated with Metyrapone] results in decreased expression of HSD17B1 mRNA; Valproic Acid affects the reaction [Colforsin affects the expression of HSD17B1 mRNA]
Colforsin results in increased expression of HSD17B1 mRNA

PMID:16935330 PMID:20726872 PMID:22446829

NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927

G

hydroxysteroid (17-beta) dehydrogenase 3

increases expression

Colforsin results in increased expression of HSD17B3 mRNA

NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554

G

hydroxysteroid (17-beta) dehydrogenase 4

affects expression
multiple interactions
increases expression

Colforsin affects the expression of HSD17B4 mRNA
Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of HSD17B4 mRNA]; Ketoconazole promotes the reaction [Colforsin results in increased expression of HSD17B4 mRNA]; Valproic Acid affects the reaction [Colforsin affects the expression of HSD17B4 mRNA]

PMID:16935330 PMID:20726872 PMID:22446829

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions

BMP6 protein inhibits the reaction [Colforsin results in increased expression of HSD3B1 mRNA]

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

increases expression
multiple interactions

Colforsin results in increased expression of HSD3B2 mRNA
[Colforsin co-treated with Ketoconazole] results in decreased expression of HSD3B2 mRNA; [Colforsin co-treated with Metyrapone] results in decreased expression of HSD3B2 mRNA; [Colforsin co-treated with triptolide] results in decreased expression of HSD3B2 mRNA; Apigenin inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]; daidzein inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]

PMID:16935330 PMID:17080404 PMID:20726872 PMID:21256172 PMID:22446829 More...

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

heat shock protein family A (Hsp70) member 5

increases response to substance

HSPA5 protein results in increased susceptibility to Colforsin

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family D (Hsp60) member 1

multiple interactions

[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA]

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

5-hydroxytryptamine receptor 1A

multiple interactions

[JB-788 binds to and results in increased activity of HTR1A protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Arachidonic Acid metabolite inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Melitten inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]

PMID:11356925 PMID:20580787

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

5-hydroxytryptamine receptor 1B

multiple interactions

HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]

NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549

G

5-hydroxytryptamine receptor 2A

multiple interactions

Colforsin inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

5-hydroxytryptamine receptor 7

multiple interactions

[Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Methiothepin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Risperidone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

G

islet amyloid polypeptide

increases expression

Colforsin results in increased expression of IAPP mRNA

NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920

G

intercellular adhesion molecule 1

multiple interactions

Colforsin inhibits the reaction [Reactive Oxygen Species results in increased expression of ICAM1 mRNA]; Colforsin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

intercellular adhesion molecule 2

multiple interactions

Colforsin inhibits the reaction [EDN1 protein results in increased expression of ICAM2 mRNA]

NCBI chr10:91,308,608...91,319,536
Ensembl chr10:91,308,538...91,315,293

G

immediate early response 3

affects response to substance

IER3 protein affects the susceptibility to Colforsin

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

interferon gamma

multiple interactions

Colforsin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

multiple interactions

Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]; FGF9 protein inhibits the reaction [Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]; FGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]]; IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 1

increases expression
multiple interactions

Colforsin results in increased expression of IGFBP1
[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of IGFBP1 mRNA

PMID:12093828 PMID:31154070

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IKBKB mRNA]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

decreases expression

Colforsin results in decreased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 11

increases expression

Colforsin results in increased expression of IL11 mRNA

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

G

interleukin 12A

decreases expression

Colforsin results in decreased expression of IL12A protein

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions
increases expression

Colforsin inhibits the reaction [oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; Colforsin results in increased expression of [IL12B protein binds to IL23A protein]
Colforsin results in increased expression of IL12B protein

PMID:10996031 PMID:15180965 PMID:20512473

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 13

decreases secretion
decreases expression

Colforsin results in decreased secretion of IL13 protein
Colforsin results in decreased expression of IL13 mRNA

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 beta

multiple interactions

Colforsin promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]

PMID:11112151 PMID:27590029

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 23 subunit alpha

increases expression
multiple interactions

Colforsin results in increased expression of IL23A protein
Colforsin results in increased expression of [IL12B protein binds to IL23A protein]

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 2 receptor subunit alpha

decreases expression

Colforsin results in decreased expression of IL2RA protein

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 4

multiple interactions

Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Miconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Miconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions

Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Miconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Miconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [terbinafine results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [terbinafine results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions
increases secretion

Colforsin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
oxophenylarsine inhibits the reaction [Colforsin results in increased secretion of IL6 protein]
Colforsin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]; Colforsin promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Colforsin promotes the reaction [TNF protein results in increased expression of IL6 mRNA]

PMID:17141199 PMID:20388727 PMID:21803157 PMID:24771768 PMID:25633564

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit beta A

multiple interactions

FST protein inhibits the reaction [INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]; INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

insulin 1

multiple interactions
increases secretion

1-Methyl-3-isobutylxanthine promotes the reaction [Colforsin results in increased secretion of INS1 protein]; Budesonide inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]; Dexamethasone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Fluticasone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Hydrocortisone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Melatonin inhibits the reaction [Colforsin results in increased secretion of INS1 protein]; Probenecid promotes the reaction [Colforsin results in increased secretion of INS1 protein]

PMID:10221768 PMID:12153439 PMID:25851902 PMID:37217659

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin induced gene 1

multiple interactions
increases expression

AR protein promotes the reaction [Colforsin results in increased expression of INSIG1 protein]
Colforsin results in increased expression of INSIG1 mRNA; Colforsin results in increased expression of INSIG1 protein

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

insulin receptor substrate 1

multiple interactions

Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA]

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

integrin subunit alpha 1

affects response to substance

ITGA1 protein affects the susceptibility to Colforsin

NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238

G

integrin subunit alpha 3

affects response to substance

ITGA3 protein affects the susceptibility to Colforsin

NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit beta 1

affects response to substance

ITGB1 protein affects the susceptibility to Colforsin

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 5

increases expression

Colforsin results in increased expression of ITGB5 mRNA

NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Colforsin results in increased expression of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

Colforsin results in increased expression of JUNB protein

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

JunD proto-oncogene, AP-1 transcription factor subunit

increases expression

Colforsin results in increased expression of JUND protein

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

potassium voltage-gated channel subfamily H member 2

multiple interactions

[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

kelch-like family member 23

multiple interactions

[Colforsin co-treated with Diethylhexyl Phthalate] affects the expression of PHOSPHO2-KLHL23 mRNA

NCBI chr 3:54,580,788...54,594,530
Ensembl chr 3:54,580,961...54,594,530

G

kallikrein 1-related peptidase C10

multiple interactions
increases expression

AR protein promotes the reaction [Colforsin results in increased expression of KLK3 protein]
Colforsin results in increased expression of KLK3 mRNA; Colforsin results in increased expression of KLK3 protein

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

kynurenine aminotransferase 1

multiple interactions
increases expression

S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Colforsin results in increased expression of KYAT1 mRNA]

NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355

G

leptin

decreases expression
multiple interactions
decreases secretion

Colforsin results in decreased expression of LEP mRNA
Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]
Colforsin results in decreased secretion of LEP protein

PMID:9002984 PMID:26367767 PMID:27381457

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

luteinizing hormone subunit beta

increases expression
multiple interactions

Colforsin results in increased expression of LHB protein
[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP; [Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone; CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]; CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]; Tetradecanoylphorbol Acetate inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]; Tetradecanoylphorbol Acetate inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]

PMID:2153673 PMID:8404651

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

luteinizing hormone/choriogonadotropin receptor

multiple interactions

[Colforsin co-treated with deoxynivalenol] results in increased expression of LHCGR mRNA; [Colforsin co-treated with Zearalenone] results in increased expression of LHCGR mRNA

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

lipase E, hormone sensitive type

affects localization

Colforsin affects the localization of LIPE protein

NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310

G

lipoprotein lipase

increases expression

Colforsin results in increased expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

latent transforming growth factor beta binding protein 2

decreases expression

Colforsin results in decreased expression of LTBP2 mRNA

NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208

G

leukotriene C4 synthase

decreases secretion

Colforsin results in decreased secretion of LTC4S protein

NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651

G

lysozyme 2

multiple interactions
increases secretion
decreases secretion

3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Colforsin results in increased secretion of LYZ protein]; [Thapsigargin co-treated with Colforsin] results in increased secretion of LYZ protein
Colforsin results in decreased secretion of LYZ protein

PMID:15194485 PMID:15234967

NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106

G

MAF bZIP transcription factor

decreases expression

Colforsin results in decreased expression of MAF mRNA

NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365

G

microtubule-associated protein 2

increases expression

Colforsin results in increased expression of MAP2 protein

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase kinase 1

multiple interactions

[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAP2K1 protein; alisol B promotes the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAP2K1 protein]

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

multiple interactions

[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAP2K2 protein; alisol B promotes the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAP2K2 protein]

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

microtubule-associated protein 7

increases expression

Colforsin results in increased expression of MAP7 mRNA

NCBI chr 1:14,910,433...15,037,574
Ensembl chr 1:14,910,551...15,037,574

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
increases activity

Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK1 protein]; Colforsin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Colforsin inhibits the reaction [Shiga Toxin results in increased activity of MAPK1 protein]
1-Methyl-3-isobutylxanthine promotes the reaction [Colforsin inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]; [Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein; Colforsin inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]; Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]; Colforsin promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Colforsin results in increased activity of MAPK1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Colforsin results in increased phosphorylation of MAPK1 protein]
[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAPK1 protein; alisol B promotes the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK1 protein]

PMID:11093795 PMID:11675405 PMID:12533312 PMID:14975937 PMID:15385614 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions
increases activity

Colforsin results in increased phosphorylation of MAPK3 protein
Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK3 protein]; Colforsin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Colforsin inhibits the reaction [Shiga Toxin results in increased activity of MAPK3 protein]
[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAPK3 protein; alisol B promotes the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAPK3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK3 protein]
1-Methyl-3-isobutylxanthine promotes the reaction [Colforsin inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]; [Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein; Colforsin inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]; Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Colforsin results in increased activity of MAPK3 protein]

PMID:11093795 PMID:11675405 PMID:12533312 PMID:14975937 PMID:15385614 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

melanocortin 2 receptor

multiple interactions
increases expression

Valproic Acid inhibits the reaction [Colforsin results in increased expression of MC2R mRNA]

PMID:20726872 PMID:25765474

NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488

G

mediator complex subunit 28

increases expression

Colforsin results in increased expression of MED28 mRNA

NCBI chr14:65,594,785...65,603,583
Ensembl chr14:65,594,647...65,603,583

G

microRNA 190

multiple interactions

Colforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]

NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071

G

melanocyte inducing transcription factor

increases expression
multiple interactions

Colforsin results in increased expression of MITF mRNA; Colforsin results in increased expression of MITF protein
[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of MITF mRNA; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of MITF protein; alisol B inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of MITF mRNA]; alisol B inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of MITF protein]

PMID:17460731 PMID:28051915 PMID:28601556

NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145

G

matrix metallopeptidase 16

increases expression

Colforsin results in increased expression of MMP16 mRNA

NCBI chr 5:31,312,280...31,556,276
Ensembl chr 5:31,312,280...31,548,388

G

mitochondrial transcription termination factor 4

decreases expression

Colforsin results in decreased expression of MTERF4 mRNA

NCBI chr 9:93,834,162...93,838,838
Ensembl chr 9:93,834,144...93,838,864

G

mucin 4, cell surface associated

increases expression

Colforsin results in increased expression of MUC4 protein

NCBI chr11:68,008,245...68,053,242

G

myosin heavy chain 7

multiple interactions

Colforsin inhibits the reaction [Dinoprostone results in increased expression of MYH7 protein]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

neuron navigator 1

decreases expression

Colforsin results in decreased expression of NAV1 mRNA

NCBI chr13:46,866,972...47,119,368
Ensembl chr13:46,873,689...47,126,449

G

nestin

decreases expression

Colforsin results in decreased expression of NES protein

NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777

G

nuclear factor kappa B subunit 1

multiple interactions

Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NFKB1 mRNA]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nerve growth factor

multiple interactions
increases expression

[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of NGF mRNA
Colforsin results in increased expression of NGF mRNA

PMID:2174743 PMID:2853697

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

N-glycanase 1

increases expression

Colforsin results in increased expression of NGLY1 mRNA

NCBI chr15:9,153,738...9,210,228
Ensembl chr15:9,153,738...9,204,630

G

neuromedin U

increases expression

Colforsin results in increased expression of NMU mRNA

NCBI chr14:31,844,564...31,872,196
Ensembl chr14:31,844,728...31,872,192

G

natriuretic peptide A

multiple interactions

Colforsin inhibits the reaction [Dinoprostone results in increased expression of NPPA protein]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:11470465 PMID:18851973

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

nuclear receptor subfamily 0, group B, member 1

decreases expression
multiple interactions

Colforsin results in decreased expression of NR0B1 mRNA
Valproic Acid inhibits the reaction [Colforsin results in decreased expression of NR0B1 mRNA]

NCBI chr X:50,756,886...50,761,014
Ensembl chr X:50,756,886...50,761,011

G

nuclear receptor subfamily 1, group I, member 2

increases activity
decreases expression

Colforsin results in increased activity of NR1I2 protein
Colforsin results in decreased expression of NR1I2 mRNA

PMID:27732639 PMID:29933105

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 3, group C, member 1

increases activity

Colforsin results in increased activity of NR3C1 protein

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 1

increases expression
multiple interactions

Colforsin results in increased expression of NR4A1 mRNA; Colforsin results in increased expression of NR4A1 protein
[Colforsin co-treated with deoxynivalenol] results in increased expression of NR4A1 mRNA; Colforsin promotes the reaction [Zearalenone results in increased expression of NR4A1 mRNA]; NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 protein]; W 7 inhibits the reaction [Colforsin results in increased expression of NR4A1 mRNA]; W 7 inhibits the reaction [Colforsin results in increased expression of NR4A1 protein]
NR4A1 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]

PMID:8164692 PMID:19822197 PMID:23183170 PMID:26783879

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 2

multiple interactions
increases expression

666-15 compound inhibits the reaction [Colforsin results in increased expression of NR4A2 mRNA]; NR4A2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]
Colforsin results in increased expression of NR4A2 mRNA; Colforsin results in increased expression of NR4A2 protein

PMID:19732956 PMID:19822197 PMID:26023867

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

nuclear receptor subfamily 4, group A, member 3

multiple interactions

NR4A3 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

nuclear receptor subfamily 5, group A, member 1

affects expression

Colforsin affects the expression of NR5A1 mRNA

NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328

G

nuclear receptor subfamily 5, group A, member 2

multiple interactions
increases expression

alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]; NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]
Colforsin results in increased expression of NR5A2 mRNA

NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326

G

neuregulin 1

multiple interactions

[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NRG1 mRNA; U 0126 inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NRG1 mRNA]

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

neurotrophin 3

increases expression

Colforsin results in increased expression of NTF3 protein

NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596

G

neurotrophic receptor tyrosine kinase 2

increases expression

Colforsin results in increased expression of NTRK2 mRNA

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

nuclear mitotic apparatus protein 1

decreases expression

Colforsin results in decreased expression of NUMA1 mRNA

NCBI chr 1:156,297,907...156,372,855
Ensembl chr 1:156,326,259...156,372,855

G

oxytocin/neurophysin I prepropeptide

multiple interactions

BMP6 protein inhibits the reaction [Colforsin results in increased expression of OXT mRNA]

NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

[Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]
Colforsin results in increased cleavage of PARP1 protein

PMID:9454737 PMID:31278978

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

paired box 8

increases expression

Colforsin results in increased expression of PAX8 mRNA; Colforsin results in increased expression of PAX8 protein

NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363

G

phosphoenolpyruvate carboxykinase 1

increases expression
multiple interactions

Colforsin results in increased expression of PCK1 mRNA
Dexamethasone promotes the reaction [Colforsin results in increased expression of PCK1 mRNA]
Colforsin inhibits the reaction [Leflunomide results in increased expression of PCK1 mRNA]; Colforsin inhibits the reaction [teriflunomide results in increased expression of PCK1 mRNA]

PMID:25851902 PMID:30364229

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

phosphodiesterase 1B

multiple interactions

PDE1B protein affects the reaction [Colforsin results in increased phosphorylation of PPP1R1B protein]

NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580

G

phosphodiesterase 2A

multiple interactions

PDE2A protein inhibits the reaction [Colforsin affects the localization of AHR protein]

NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434

G

phosphodiesterase 4B

increases expression

Colforsin results in increased expression of PDE4B mRNA

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

phosphodiesterase 4D

increases expression

Colforsin results in increased expression of PDE4D mRNA

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

G

pyruvate dehydrogenase kinase 1

affects response to substance
multiple interactions

PDK1 protein affects the susceptibility to Colforsin
[PDK1 protein affects the susceptibility to Colforsin] which affects the abundance of Cyclic AMP; tubacin affects the reaction [[PDK1 protein affects the susceptibility to Colforsin] which affects the abundance of Cyclic AMP]

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

proenkephalin

multiple interactions
increases expression

Cycloheximide promotes the reaction [Colforsin results in increased expression of PENK mRNA]; Dexamethasone promotes the reaction [Colforsin results in increased expression of PENK mRNA]

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

period circadian regulator 1

multiple interactions
increases expression

[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA; AHR protein inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA]; beta-Naphthoflavone inhibits the reaction [Colforsin results in increased expression of PER1 mRNA]

NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431

G

placental growth factor

increases expression
multiple interactions

Colforsin results in increased expression of PGF mRNA
perfluorooctane sulfonic acid inhibits the reaction [Colforsin results in increased expression of PGF mRNA]

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

progesterone receptor

increases expression

Colforsin results in increased expression of PGR mRNA

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

protein inhibitor of activated STAT, 1

decreases expression

Colforsin results in decreased expression of PIAS1 mRNA

NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905

G

PTEN induced kinase 1

multiple interactions

PINK1 protein affects the reaction [Colforsin results in decreased expression of DNM1L protein]

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

phospholipase A2 group IIA

multiple interactions

Colforsin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]

NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014

G

patatin-like phospholipase domain containing 2

multiple interactions

PNPLA2 protein affects the reaction [Colforsin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]

NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805

G

patatin-like phospholipase domain containing 6

multiple interactions
increases expression

1-Methyl-3-isobutylxanthine promotes the reaction [Colforsin results in increased expression of and results in increased activity of PNPLA6 protein]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PNPLA6 mRNA; Colforsin results in increased expression of and results in increased activity of PNPLA6 protein; Cycloheximide inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of PNPLA6 protein]; Cycloheximide inhibits the reaction [Colforsin results in increased activity of PNPLA6 protein]
Colforsin results in increased expression of PNPLA6 mRNA

NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734

G

proopiomelanocortin

multiple interactions

Colforsin inhibits the reaction [diethyl phosphate results in decreased secretion of POMC protein]

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

POU class 1 homeobox 1

multiple interactions

Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]; resveratrol inhibits the reaction [Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]]

NCBI chr11:3,316,818...3,334,804
Ensembl chr11:3,317,058...3,334,801

G

peroxisome proliferator-activated receptor gamma

decreases expression

Colforsin results in decreased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

increases expression

Colforsin results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

PPARG coactivator 1 beta

increases expression

Colforsin results in increased expression of PPARGC1B mRNA

NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194

G

protein phosphatase 1, regulatory subunit 12A

increases phosphorylation
multiple interactions

Colforsin results in increased phosphorylation of PPP1R12A protein
Capsaicin inhibits the reaction [Colforsin results in increased phosphorylation of PPP1R12A protein]; capsazepine inhibits the reaction [Colforsin results in increased phosphorylation of PPP1R12A protein]

NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

increases phosphorylation
multiple interactions

Colforsin results in increased phosphorylation of PPP1R1B protein
PDE1B protein affects the reaction [Colforsin results in increased phosphorylation of PPP1R1B protein]

NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775

G

peroxiredoxin 2

increases expression
multiple interactions
decreases expression

Colforsin results in increased expression of PRDX2 mRNA
S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Colforsin results in increased expression of PRDX2 mRNA]
Colforsin results in decreased expression of PRDX2 mRNA

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

proline rich membrane anchor 1

increases expression

Colforsin results in increased expression of PRIMA1 mRNA

NCBI chr 6:122,338,365...122,390,955
Ensembl chr 6:122,338,370...122,389,921

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

Colforsin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PNPLA2 protein affects the reaction [Colforsin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase cAMP-activated catalytic subunit alpha

multiple interactions
increases activity

Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]
Colforsin results in increased activity of PRKACA protein

PMID:16339297 PMID:28601556

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

G

protein kinase cAMP-activated catalytic subunit beta

multiple interactions

[PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]] results in decreased stability of [PRKACB protein mutant form binds to PRKAR1A protein]; [PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]] results in decreased stability of [PRKACB protein mutant form binds to PRKAR1B protein]; PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]

NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198

G

protein kinase cAMP-dependent type I regulatory subunit alpha

multiple interactions

[PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]] results in decreased stability of [PRKACB protein mutant form binds to PRKAR1A protein]

NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041

G

protein kinase cAMP-dependent type I regulatory subunit beta

multiple interactions

[PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]] results in decreased stability of [PRKACB protein mutant form binds to PRKAR1B protein]

NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942

G

protein kinase cAMP-dependent type II regulatory subunit alpha

increases phosphorylation

Colforsin results in increased phosphorylation of PRKAR2A protein

NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628

G

prolactin

multiple interactions
increases expression

Colforsin inhibits the reaction [Octreotide results in decreased secretion of PRL protein]; Octreotide inhibits the reaction [Colforsin results in increased expression of PRL protein]
[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA; [Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein; Cannabidiol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]; Cannabidiol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein]; Cannabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]; Cannabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein]; Dronabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]; Dronabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein]; Rimonabant inhibits the reaction [Dronabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]]

PMID:1322274 PMID:31154070

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

pentatricopeptide repeat domain 1

multiple interactions

[Colforsin co-treated with Diethylhexyl Phthalate] affects the expression of ATP5MF-PTCD1 mRNA

NCBI chr12:9,445,656...9,463,434
Ensembl chr12:9,445,714...9,463,508

G

patched 1

multiple interactions

Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTCH1 mRNA]

NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

Colforsin promotes the reaction [bisperoxovanadium results in increased expression of PTGS2 mRNA]; Colforsin promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
Colforsin results in increased expression of PTGS2 mRNA
bifenthrin inhibits the reaction [Colforsin results in increased expression of PTGS2 mRNA]; Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]
Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; Colforsin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]

PMID:11112151 PMID:12493747 PMID:15213229 PMID:17407152 PMID:19063610 More...

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RAP1A, member of RAS oncogene family

increases activity
multiple interactions

Colforsin results in increased activity of RAP1A protein
Rolipram affects the reaction [Colforsin results in increased activity of RAP1A protein]

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

RAP1B, member of RAS oncogene family

multiple interactions
increases activity

Rolipram affects the reaction [Colforsin results in increased activity of RAP1B protein]

NCBI chr 7:53,423,039...53,456,349
Ensembl chr 7:53,423,130...53,456,370

G

retinoic acid receptor responder 2

multiple interactions

RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 protein]; RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 protein]

NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556

G

RB transcriptional corepressor 1

multiple interactions

[Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in decreased phosphorylation of RB1 protein]

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; Colforsin inhibits the reaction [Morphine results in increased phosphorylation of RELA protein]
RELA affects the reaction [[monobutyl phthalate co-treated with Colforsin] results in increased secretion of Progesterone]

PMID:22258905 PMID:26745512 PMID:27590029

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RELB proto-oncogene, NF-kB subunit

multiple interactions

Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]]

NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507

G

renin

increases expression
multiple interactions
increases secretion

Colforsin results in increased expression of REN mRNA
[Sodium, Dietary deficiency results in increased susceptibility to Colforsin] which results in increased secretion of REN protein
Colforsin results in increased secretion of REN protein

PMID:9256163 PMID:10432392

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

ring finger protein 4

multiple interactions

[Tetradecanoylphorbol Acetate co-treated with Colforsin] results in increased expression of RNF4 mRNA

NCBI chr14:76,401,292...76,423,270
Ensembl chr14:76,401,299...76,422,566

G

ribosomal RNA processing 12

increases expression

Colforsin results in increased expression of RRP12 mRNA

NCBI chr 1:240,672,378...240,705,992
Ensembl chr 1:240,672,382...240,706,018

G

RUNX family transcription factor 1

affects splicing
multiple interactions

Colforsin affects the splicing of RUNX1 exon
HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of RUNX1 exon]

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

RUNX family transcription factor 2

increases expression

Colforsin results in increased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

syndecan 1

increases expression
multiple interactions

Colforsin results in increased expression of SDC1 mRNA
[Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [Colforsin results in increased expression of SDC1 mRNA]

PMID:35908931 PMID:38296531

NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264

G

selectin E

multiple interactions

[Colforsin co-treated with Rolipram] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased secretion of SELE protein]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

selenoprotein P

multiple interactions

Colforsin promotes the reaction [Dexamethasone results in increased expression of SELENOP mRNA]

NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852

G

sestrin 1

decreases expression
multiple interactions

Colforsin results in decreased expression of SESN1 mRNA; Colforsin results in decreased expression of SESN1 protein
AR protein affects the reaction [Colforsin results in decreased expression of SESN1 protein]

NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697

G

surfactant protein C

increases expression

Colforsin results in increased expression of SFTPC mRNA

NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777

G

sirtuin 1

multiple interactions

SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; SIRT1 protein inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; SIRT1 protein mutant form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]
Colforsin inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]

PMID:23292070 PMID:30825513

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 1 member 5

multiple interactions
decreases expression

Valproic Acid promotes the reaction [Colforsin results in decreased expression of SLC1A5 protein]
Colforsin results in decreased expression of SLC1A5 mRNA; Colforsin results in decreased expression of SLC1A5 protein

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 26 member 4

increases expression

Colforsin results in increased expression of SLC26A4 protein

NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703

G

solute carrier family 2 member 1

multiple interactions
increases expression

cobaltous chloride inhibits the reaction [Valproic Acid inhibits the reaction [Colforsin results in increased expression of SLC2A1 protein]]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of SLC2A1 protein]

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 4

multiple interactions

Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SLC2A4 mRNA]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 2 member 5

multiple interactions
increases expression

Colforsin promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Colforsin promotes the reaction [Glucose results in increased expression of SLC2A5 mRNA]
[[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of SLC2A5 protein] which results in increased uptake of Fructose; [Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of SLC2A5 protein; Colforsin results in increased expression of and results in decreased degradation of SLC2A5 mRNA
Colforsin results in increased expression of SLC2A5 mRNA

PMID:8037665 PMID:12820898

NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106

G

solute carrier family 30 member 1

increases expression

Colforsin results in increased expression of SLC30A1 mRNA

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

G

solute carrier family 30 member 2

increases expression

Colforsin results in increased expression of SLC30A2 mRNA

NCBI chr 5:146,559,733...146,571,957
Ensembl chr 5:146,559,733...146,571,956

G

solute carrier family 30 member 4

increases expression

Colforsin results in increased expression of SLC30A4 mRNA

NCBI chr 3:109,753,270...109,775,306
Ensembl chr 3:109,753,273...109,775,306

G

solute carrier family 30 member 7

decreases expression

Colforsin results in decreased expression of SLC30A7 mRNA

NCBI chr 2:203,855,484...203,922,155
Ensembl chr 2:203,859,175...203,922,132

G

solute carrier family 3 member 2

increases expression

Colforsin results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 45, member 2

increases expression

Colforsin results in increased expression of SLC45A2 mRNA

NCBI chr 2:59,963,599...59,996,408
Ensembl chr 2:59,963,706...59,996,317

G

solute carrier family 5 member 5

multiple interactions
increases expression

Colforsin inhibits the reaction [[Tretinoin co-treated with Hydrocortisone] results in increased activity of SLC5A5 protein]
Colforsin results in increased expression of SLC5A5 mRNA; Colforsin results in increased expression of SLC5A5 protein

PMID:16439463 PMID:16954431

NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697

G

solute carrier family 7 member 5

increases expression

Colforsin results in increased expression of SLC7A5 mRNA; Colforsin results in increased expression of SLC7A5 protein

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

solute carrier family 7 member 8

increases expression

Colforsin results in increased expression of SLC7A8 mRNA

NCBI chr15:28,183,013...28,242,717
Ensembl chr15:28,183,015...28,242,717

G

smoothened, frizzled class receptor

multiple interactions

Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMO mRNA]

NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829

G

snail family transcriptional repressor 1

decreases expression

Colforsin results in decreased expression of SNAI1 mRNA

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

decreases expression

Colforsin results in decreased expression of SNAI2 mRNA

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

synaptosome associated protein 25

affects splicing
multiple interactions

Colforsin affects the splicing of SNAP25 exon
Colforsin promotes the reaction [HNRNPK protein binds to SNAP25 exon]; HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of SNAP25 exon]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin affects the splicing of SNAP25 exon]

NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760

G

suppressor of cytokine signaling 3

multiple interactions
increases expression

Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]
Colforsin results in increased expression of SOCS3 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]; [[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein; dorsomorphin inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]

PMID:17407152 PMID:23782265

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

superoxide dismutase 1

multiple interactions

[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression
multiple interactions
increases activity

Colforsin results in increased expression of SOD2 mRNA
[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein]
Colforsin results in increased activity of SOD2 protein

PMID:12093828 PMID:32092105

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SRY-box transcription factor 2

decreases expression

Colforsin results in decreased expression of SOX2 protein

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

signal peptidase complex subunit 3

increases expression

Colforsin results in increased expression of SPCS3 mRNA

NCBI chr16:37,305,358...37,310,792
Ensembl chr16:37,305,305...37,331,746

G

sequestosome 1

increases degradation

Colforsin results in increased degradation of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

steroid 5 alpha-reductase 1

increases expression

Colforsin results in increased expression of SRD5A1 mRNA

NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461

G

sterol regulatory element binding transcription factor 1

multiple interactions

Colforsin promotes the reaction [Diethylhexyl Phthalate results in decreased expression of SREBF1 protein]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sterol regulatory element binding transcription factor 2

multiple interactions

Colforsin inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

somatostatin

multiple interactions

[SST protein co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]

NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173

G

somatostatin receptor 2

multiple interactions

[64Cu-CB-TE2A-Y3-TATE co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [SST protein co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]

NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351

G

steroidogenic acute regulatory protein

multiple interactions
increases expression

[Colforsin co-treated with Diethylhexyl Phthalate] results in increased expression of STAR protein; BMP6 protein inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of STAR mRNA]
[Colforsin co-treated with deoxynivalenol] results in increased expression of STAR mRNA; Colforsin affects the reaction [Zearalenone results in increased expression of STAR mRNA]; ferulic acid analog promotes the reaction [Colforsin results in increased expression of STAR mRNA]; ferulic acid analog promotes the reaction [Colforsin results in increased expression of STAR protein]; NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]; W 7 inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; W 7 inhibits the reaction [Colforsin results in increased expression of STAR protein]
Colforsin results in increased expression of STAR mRNA; Colforsin results in increased expression of STAR protein
[Atrazine co-treated with Colforsin] results in increased expression of STAR mRNA

PMID:14691014 PMID:15967414 PMID:16254025 PMID:16935330 PMID:17080404 More...

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

sulfotransferase family 1E member 1

decreases expression

Colforsin results in decreased expression of SULT1E1 mRNA

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

sulfotransferase family 2A member 1

decreases expression
multiple interactions

Colforsin results in decreased expression of SULT2A1 mRNA
Hexachlorocyclohexane promotes the reaction [Colforsin results in decreased expression of SULT2A1 mRNA]

PMID:17080404 PMID:22446829

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

sulfotransferase family 2B member 1

decreases expression

Colforsin results in decreased expression of SULT2B1 mRNA

NCBI chr 1:96,200,155...96,261,295
Ensembl chr 1:96,200,156...96,261,295

G

tachykinin, precursor 1

multiple interactions

Colforsin promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]; HU 211 inhibits the reaction [Colforsin promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]]

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

T-box brain transcription factor 1

multiple interactions

Colforsin promotes the reaction [CASK protein modified form binds to TBR1 protein]

NCBI chr 3:46,350,237...46,368,397
Ensembl chr 3:46,351,213...46,361,041

G

testin gene

affects expression

Colforsin affects the expression of TESTIN mRNA

NCBI chr17:3,824,222...3,859,385
Ensembl chr17:3,846,899...3,859,385

G

transforming growth factor, beta 1

multiple interactions

Colforsin inhibits the reaction [Dronabinol results in increased expression of TGFB1 protein]; TGFB1 protein inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]
Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]

PMID:11779138 PMID:15625562 PMID:27590029

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

trimethylguanosine synthase 1

increases expression

Colforsin results in increased expression of TGS1 mRNA

NCBI chr 5:16,524,864...16,558,399
Ensembl chr 5:16,524,874...16,558,399

G

tyrosine hydroxylase

multiple interactions
increases expression
increases activity

3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased expression of TH mRNA]; bisindolylmaleimide I inhibits the reaction [Colforsin results in increased expression of TH mRNA]; HU 211 inhibits the reaction [Colforsin results in increased expression of TH mRNA]; KT 5720 inhibits the reaction [Colforsin results in increased expression of TH mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of TH mRNA]
Colforsin results in increased expression of TH protein
Colforsin results in increased activity of TH protein
Colforsin results in increased expression of TH mRNA; Colforsin results in increased expression of TH protein

PMID:9288946 PMID:14550852 PMID:18992715 PMID:34897981

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

TIMP metallopeptidase inhibitor 1

increases expression

Colforsin results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

multiple interactions
increases expression

Colforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein]
Colforsin results in increased expression of TIMP2 protein

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

transmembrane protein 50A

increases expression

Colforsin results in increased expression of TMEM50A mRNA

NCBI chr 5:147,123,670...147,138,859
Ensembl chr 5:147,123,688...147,138,849

G

tumor necrosis factor

multiple interactions
decreases expression

Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]; Colforsin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Colforsin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
[Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased secretion of SELE protein]; Colforsin inhibits the reaction [3,4-dihydroxyphenylethanol promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Colforsin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Colforsin inhibits the reaction [Shiga Toxin results in increased expression of TNF mRNA]; Colforsin promotes the reaction [TNF protein results in increased expression of IL6 mRNA]
Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Colforsin inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; Colforsin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; Colforsin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Colforsin results in decreased expression of TNF protein

PMID:8780174 PMID:10495789 PMID:10996031 PMID:11675405 PMID:12509806 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

transducer of ErbB-2.1

increases expression

Colforsin results in increased expression of TOB1 mRNA

NCBI chr10:79,163,093...79,165,131
Ensembl chr10:79,160,154...79,165,215

G

tumor protein p53

increases expression

Colforsin results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

Colforsin promotes the reaction [Capsaicin results in increased activity of TRPV1]
Colforsin promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Colforsin promotes the reaction [Capsaicin results in increased activity of TRPV1]

PMID:12886029 PMID:17913835

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

tubulin, beta 3 class III

increases expression

Colforsin results in increased expression of TUBB3 protein

NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243

G

thioredoxin interacting protein

increases activity

Colforsin results in increased activity of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

tyrosinase

increases activity
decreases expression
increases expression
multiple interactions

Colforsin results in increased activity of TYR protein
Colforsin results in decreased expression of TYR protein
Colforsin results in increased expression of TYR protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Colforsin results in increased expression of TYR protein]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of TYR protein; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TYR mRNA; [Colforsin co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Colforsin co-treated with Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] promotes the reaction [Colforsin results in increased expression of TYR protein]; alisol B inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of TYR protein]; alisol B inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TYR mRNA]; glabridin inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of TYR protein]
Colforsin results in increased expression of TYR mRNA
[resveratrol co-treated with Colforsin] results in decreased activity of TYR protein; [Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYR mRNA]; Colforsin results in increased expression of and results in increased activity of TYR protein; Particulate Matter inhibits the reaction [Colforsin results in increased expression of TYR mRNA]

PMID:17460731 PMID:23700242 PMID:28051915 PMID:28601556 PMID:28849034

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

tyrosinase-related protein 1

increases expression
multiple interactions

Colforsin results in increased expression of TYRP1 mRNA; Colforsin results in increased expression of TYRP1 protein
[Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYRP1 mRNA]; Particulate Matter inhibits the reaction [Colforsin results in increased expression of TYRP1 mRNA]

PMID:17460731 PMID:23700242 PMID:28601556

NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516

G

ubiquitin-conjugating enzyme E2, J1

increases expression

Colforsin results in increased expression of UBE2J1 mRNA

NCBI chr 5:47,422,476...47,441,476
Ensembl chr 5:47,422,587...47,441,461

G

uncoupling protein 1

multiple interactions

Colforsin inhibits the reaction [geniposide results in decreased expression of UCP1 mRNA]; Colforsin inhibits the reaction [geniposide results in decreased expression of UCP1 protein]

NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852

G

upstream transcription factor 1

multiple interactions

USF1 gene polymorphism promotes the reaction [Colforsin results in increased metabolism of Lipids]; USF1 protein affects the reaction [Colforsin results in increased metabolism of Lipids]

NCBI chr13:83,845,230...83,854,875
Ensembl chr13:83,822,035...83,854,885

G

vasodilator-stimulated phosphoprotein

increases phosphorylation
multiple interactions

Colforsin results in increased phosphorylation of VASP protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of VASP protein]

PMID:18182247 PMID:32409581

NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061

G

vascular endothelial growth factor A

multiple interactions
increases expression

Colforsin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of VEGFA mRNA]

PMID:10788502 PMID:19063610

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

multiple interactions

VIM affects the reaction [[monobutyl phthalate co-treated with Colforsin] results in increased secretion of Progesterone]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

WT1 transcription factor

increases expression

Colforsin results in increased expression of WT1 mRNA

NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643

G

X-linked inhibitor of apoptosis

multiple interactions

[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP protein] which results in decreased susceptibility to Cisplatin; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP mRNA; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

zinc finger and BTB domain containing 10

decreases expression

Colforsin results in decreased expression of ZBTB10 mRNA

NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515

G

zinc finger protein 36, C3H type-like 1

increases expression

Colforsin results in increased expression of ZFP36L1 mRNA

NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748

G

zinc finger protein 36, C3H type-like 2

decreases expression

Colforsin results in decreased expression of ZFP36L2 mRNA

NCBI chr 6:10,490,032...10,494,073
Ensembl chr 6:10,490,032...10,494,064

forskolin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 6 member 4

increases activity

forskolin increases activity of SLC6A4 protein in placental choriocarcinoma cells

RGD

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19867
role	19837
biological role	19835
pharmacological role	19069
agonist	18596
adenylate cyclase agonist	350
colforsin daropate	0
colforsin daropate hydrochloride	348
forskolin +	4

paths to the root