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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:apremilast
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Accession:CHEBI:78540 term browser browse the term
Definition:A member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis.
Synonyms:exact_synonym: N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
 related_synonym: CC-10004;   CC10004;   Formula=C22H24N2O7S;   InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1;   InChIKey=IMOZEMNVLZVGJZ-QGZVFWFLSA-N;   OTEZLA;   SMILES=CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O;   apremilastum
 xref: CAS:608141-41-9;   Drug_Central:4829;   KEGG:D08860
 xref_mesh: MESH:C505730
 xref: PMID:22910104;   PMID:22984171;   PMID:23030767;   PMID:23569359;   PMID:23588944;   PMID:23663752;   PMID:23986162;   PMID:24072562;   PMID:24592316;   PMID:24595547;   PMID:24702658;   PMID:24797159;   PMID:24846499;   PMID:24852768;   PMID:24869713;   PMID:24882690;   PMID:24962564;   PMID:24979544;   PMID:24997741;   PMID:24998661;   PMID:25027606;   PMID:25050054;   PMID:25054629;   Reaxys:12446985;   Wikipedia:Apremilast


show annotations for term's descendants           Sort by:
apremilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased activity of CASP3 protein] CTD PMID:27785949 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of CKM protein] CTD PMID:27785949 NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of GOT1 protein] CTD PMID:27785949 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of LDHA protein] CTD PMID:27785949 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK1 mRNA] CTD PMID:27785949 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK8 mRNA] CTD PMID:27785949 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in decreased expression of NFKBIA protein] CTD PMID:27785949 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of RELA mRNA] CTD PMID:27785949 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        anti-inflammatory agent 16834
          anti-inflammatory drug 15100
            non-steroidal anti-inflammatory drug 14404
              apremilast 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              acetamides 14869
                                                N-acetylarylamine 8
                                                  apremilast 8
paths to the root