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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:apremilast
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Accession:CHEBI:78540 term browser browse the term
Definition:A member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis.
Synonyms:exact_synonym: N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
 related_synonym: CC-10004;   CC10004;   Formula=C22H24N2O7S;   InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1;   InChIKey=IMOZEMNVLZVGJZ-QGZVFWFLSA-N;   OTEZLA;   SMILES=CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O;   apremilastum
 xref: CAS:608141-41-9;   Drug_Central:4829;   KEGG:D08860
 xref_mesh: MESH:C505730
 xref: PMID:22910104;   PMID:22984171;   PMID:23030767;   PMID:23569359;   PMID:23588944;   PMID:23663752;   PMID:23986162;   PMID:24072562;   PMID:24592316;   PMID:24595547;   PMID:24702658;   PMID:24797159;   PMID:24846499;   PMID:24852768;   PMID:24869713;   PMID:24882690;   PMID:24962564;   PMID:24979544;   PMID:24997741;   PMID:24998661;   PMID:25027606;   PMID:25050054;   PMID:25054629;   Reaxys:12446985;   Wikipedia:Apremilast


show annotations for term's descendants           Sort by:
apremilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased activity of CASP3 protein] CTD PMID:27785949 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of CKM protein] CTD PMID:27785949 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of GOT1 protein] CTD PMID:27785949 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of LDHA protein] CTD PMID:27785949 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK1 mRNA] CTD PMID:27785949 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK8 mRNA] CTD PMID:27785949 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in decreased expression of NFKBIA protein] CTD PMID:27785949 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of RELA mRNA] CTD PMID:27785949 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        anti-inflammatory agent 16672
          anti-inflammatory drug 14964
            non-steroidal anti-inflammatory drug 14280
              apremilast 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17550
                                            carboxamide 17550
                                              acetamides 14628
                                                N-acetylarylamine 8
                                                  apremilast 8
paths to the root