The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo).
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of AKT1 mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of AKT1 protein afimoxifene inhibits the reaction [icariin results in increased phosphorylation of AKT1 protein]; icariin affects the reaction [Diethylhexyl Phthalate affects the phosphorylation of AKT1 protein]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of AKT1 protein]; icariin inhibits the reaction [MK 2206 results in decreased phosphorylation of AKT1 protein]
icariin inhibits the reaction [APP protein alternative form results in decreased expression of SOD2 mRNA]; icariin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 mRNA]
icariin affects the expression of BCL2 protein icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein]
icariin affects the expression of BCL2L11 protein icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased expression of BCL2L11 protein]
NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]
[naphthol AS-E phosphate co-treated with icariin] results in increased phosphorylation of CREB1 protein; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of CREB1 protein]; icariin inhibits the reaction [MK 2206 results in decreased phosphorylation of CREB1 protein] icariin results in increased phosphorylation of CREB1 protein
icariin results in increased expression of CYP11A1 mRNA; icariin results in increased expression of CYP11A1 protein [icariin co-treated with Diethylhexyl Phthalate] results in increased expression of CYP11A1 mRNA; [icariin co-treated with naphthol AS-E phosphate] results in decreased expression of CYP11A1 protein; [MK 2206 co-treated with icariin] results in increased expression of CYP11A1 mRNA; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP11A1 protein]; icariin inhibits the reaction [MK 2206 results in decreased expression of CYP11A1 protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of EGFR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of EGFR mRNA
icariin results in increased expression of FOS mRNA; icariin results in increased expression of FOS protein SB 203580 inhibits the reaction [icariin results in increased expression of FOS protein]; U 0126 inhibits the reaction [icariin results in increased expression of FOS protein]
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]; Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]] icariin affects the localization of FOXO3 protein
icariin inhibits the reaction [Folic Acid results in increased expression of HAVCR1 mRNA]; icariin inhibits the reaction [Folic Acid results in increased expression of HAVCR1 protein]
icariin results in increased expression of HSD3B1 mRNA; icariin results in increased expression of HSD3B1 protein icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 mRNA]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL1B protein; icariin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein] icariin results in increased expression of IL1B protein icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of IL1B protein]; MIR206 affects the reaction [icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of IL1B protein]]
icariin affects the expression of IL6 protein [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL6 protein; icariin inhibits the reaction [Dietary Fats results in increased expression of IL6 protein] icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of IL6 protein]; MIR206 affects the reaction [icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of IL6 protein]]
icariin results in increased expression of JUN mRNA; icariin results in increased expression of JUN protein SB 203580 inhibits the reaction [icariin results in increased expression of JUN protein]; U 0126 inhibits the reaction [icariin results in increased expression of JUN protein]
U 0126 inhibits the reaction [icariin results in increased phosphorylation of MAPK1 protein] icariin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK1 protein]; icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased phosphorylation of MAPK1 protein]
U 0126 inhibits the reaction [icariin results in increased phosphorylation of MAPK3 protein] icariin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK3 protein]; icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased phosphorylation of MAPK3 protein]
icariin affects the localization of MEF2C protein SB 203580 inhibits the reaction [icariin affects the localization of MEF2C protein]; SB 203580 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]; U 0126 inhibits the reaction [icariin affects the localization of MEF2C protein]; U 0126 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]
icariin inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of MIR206 mRNA]; MIR206 affects the reaction [icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of IL1B protein]]; MIR206 affects the reaction [icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of IL6 protein]] icariin inhibits the reaction [Dietary Fats results in decreased expression of MIR206 mRNA]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of MMP9 protein
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of MTOR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MTOR mRNA
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5B mRNA
icariin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein; SB 203580 inhibits the reaction [icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; U 0126 inhibits the reaction [icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
NOG protein inhibits the reaction [icariin results in decreased expression of TNFSF11 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of BMP2 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of RUNX2 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of TNFRSF11B mRNA]
icariin results in increased expression of NOS2 mRNA; icariin results in increased expression of NOS2 protein icariin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
icariin results in increased expression of NOS3 mRNA icariin promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; icariin results in increased expression of and results in increased activity of NOS3 protein icariin results in increased expression of NOS3 mRNA; icariin results in increased expression of NOS3 protein
icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NR5A1 mRNA]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NR5A1 protein] icariin results in increased expression of NR5A1 mRNA; icariin results in increased expression of NR5A1 protein
icariin analog results in decreased activity of PDE5A protein; icariin results in decreased activity of PDE5A protein icariin results in decreased expression of PDE5A mRNA alternative form
icariin results in increased expression of PPARGC1A mRNA; icariin results in increased expression of PPARGC1A protein Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]]; icariin inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]
icariin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
icariin results in increased activity of RELA protein icariin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; icariin results in increased expression of and affects the localization of RELA protein; SB 203580 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein]; U 0126 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein] icariin inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein]; icariin inhibits the reaction [Fatty Acids, Nonesterified results in increased phosphorylation of RELA protein]
icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]; icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]] icariin results in increased expression of SIRT1 mRNA; icariin results in increased expression of SIRT1 protein icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]; Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]] icariin affects the expression of SIRT1 mRNA; icariin affects the expression of SIRT1 protein
Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein]]; icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein]
icariin results in decreased activity of SLCO1B3 protein [icariin results in decreased activity of SLCO1B3 protein] which results in decreased uptake of Sincalide
SMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]
icariin inhibits the reaction [APP protein alternative form results in decreased expression of SOD2 mRNA] icariin affects the expression of SOD2 protein icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SOD2 protein]
icariin inhibits the reaction [Folic Acid results in increased expression of SPP1 protein]; NOG protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]
icariin results in increased phosphorylation of SRC protein afimoxifene inhibits the reaction [icariin results in increased phosphorylation of SRC protein]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of SRC protein]
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of TIMP1 protein
icariin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] icariin affects the expression of TNF protein [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of TNF protein
icariin results in increased expression of TNFRSF11B mRNA NOG protein inhibits the reaction [icariin results in increased expression of TNFRSF11B mRNA]
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