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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor
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Accession:CHEBI:78377 term browser browse the term
Definition:An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of acyl-CoA dehydrogenase (NADP(+)), EC 1.3.1.8.
Synonyms:related_synonym: 2-enoyl-CoA reductase inhibitor;   2-enoyl-CoA reductase inhibitors;   EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitors;   EC 1.3.1.8 inhibitor;   EC 1.3.1.8 inhibitors;   acyl-CoA dehydrogenase (NADP(+)) inhibitor;   acyl-CoA dehydrogenase (NADP(+)) inhibitors;   acyl-CoA:NADP(+) 2-oxidoreductase inhibitor;   acyl-CoA:NADP(+) 2-oxidoreductase inhibitors;   crotonyl coenzyme A reductase inhibitor;   crotonyl coenzyme A reductase inhibitors;   crotonyl-CoA reductase inhibitor;   crotonyl-CoA reductase inhibitors;   dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate) inhibitor;   dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate) inhibitors;   enoyl coenzyme A reductase inhibitor;   enoyl coenzyme A reductase inhibitors
 xref: Wikipedia:Acyl-CoA_dehydrogenase_(NADP%2B)



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ebselen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 multiple interactions ISO ebselen inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein] CTD PMID:17018608 NCBI chr 8:25,439,627...25,507,138
Ensembl chr 8:25,439,627...25,506,943
JBrowse link
G Afp alpha fetoprotein multiple interactions ISO ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA] CTD PMID:11133813 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766
JBrowse link
G Alad aminolevulinate, delta-, dehydratase multiple interactions
decreases activity
ISO
EXP
Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]
ebselen inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]
CTD PMID:14630126 PMID:17624921 PMID:23933410 NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity ISO ebselen results in decreased activity of ALOX5 protein CTD PMID:7590103 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO ebselen inhibits the reaction [sodium arsenite results in increased expression of BAX protein] CTD PMID:30558456 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO ebselen inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein] CTD PMID:30558456 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP3 protein]
ebselen inhibits the reaction [Methylmercury Compounds results in increased activity of CASP3 protein]; ebselen inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]
ebselen results in increased activity of CASP3 protein
CTD PMID:21300091 PMID:23649643 PMID:25068500 PMID:30558456 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 multiple interactions ISO ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP9 protein]
ebselen inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein]
CTD PMID:18629305 PMID:23649643 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase increases activity
multiple interactions
ISO ebselen results in increased activity of CAT protein
ebselen inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
CTD PMID:27282967 PMID:30558456 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 increases expression ISO ebselen results in increased expression of COX4I1 protein CTD PMID:27385396 NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946
JBrowse link
G Cs citrate synthase multiple interactions ISO ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]
ebselen inhibits the reaction [Cisplatin results in decreased activity of CS protein]
CTD PMID:27385396 PMID:32860823 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO ebselen inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; ebselen inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; ebselen inhibits the reaction [Peroxynitrous Acid results in increased expression of CXCL8 mRNA]; ebselen inhibits the reaction [Peroxynitrous Acid results in increased expression of CXCL8 protein] CTD PMID:14572605 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA] CTD PMID:11903743 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha increases phosphorylation ISO ebselen results in increased phosphorylation of EIF2S1 protein CTD PMID:27282967 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic multiple interactions ISO ebselen binds to and results in decreased activity of EPHX2 protein CTD PMID:23219563 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949
JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 multiple interactions ISO ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein] CTD PMID:27385396 NCBI chr  X:67,722,144...67,761,569
Ensembl chr  X:67,722,147...67,761,569
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] CTD PMID:14572605 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO ebselen inhibits the reaction [Cisplatin results in increased activity of G6PC1 protein] CTD PMID:32860823 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729
JBrowse link
G Gck glucokinase multiple interactions EXP [ebselen co-treated with Glucose] results in increased activity of GCK protein CTD PMID:23795780 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081
JBrowse link
G Gfap glial fibrillary acidic protein increases phosphorylation ISO ebselen results in increased phosphorylation of GFAP protein CTD PMID:27282967 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]; ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein] CTD PMID:12958040 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP
ISO
ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
ebselen inhibits the reaction [Methylmercury Compounds results in decreased activity of GPX1 protein]
CTD PMID:23795780 PMID:28383113 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gsr glutathione reductase increases activity
multiple interactions
ISO ebselen results in increased activity of GSR protein
ebselen inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]
CTD PMID:27282967 PMID:30558456 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions ISO ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein] CTD PMID:8147899 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 multiple interactions ISO ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein] CTD PMID:8147899 NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO ebselen binds to and results in decreased activity of GSTP1 protein CTD PMID:8147899 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]] CTD PMID:19374849 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [ebselen affects the abundance of Reactive Oxygen Species] which results in decreased expression of HMOX1 protein; [ebselen affects the abundance of Reactive Oxygen Species] which results in increased activity of HMOX1 protein CTD PMID:16959961 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase increases expression EXP ebselen results in increased expression of HPGDS mRNA CTD PMID:21669866 NCBI chr 6:65,094,019...65,121,960
Ensembl chr 6:65,094,277...65,121,892
JBrowse link
G Hsf1 heat shock factor 1 increases activity ISO ebselen results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
JBrowse link
G Ifng interferon gamma multiple interactions EXP ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:12794164 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il6 interleukin 6 multiple interactions ISO ebselen inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] CTD PMID:30558456 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins1 insulin I multiple interactions EXP ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen promotes the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:23795780 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
EXP
ISO
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]
ebselen analog results in increased phosphorylation of MAPK1 protein; ebselen results in increased phosphorylation of MAPK1 protein
ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK1 protein]
ebselen results in increased activity of MAPK1 protein
CTD PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
increases activity
EXP
ISO
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK3 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK3 protein]
ebselen analog results in increased phosphorylation of MAPK3 protein; ebselen results in increased phosphorylation of MAPK3 protein
ebselen results in increased activity of MAPK3 protein
CTD PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO ebselen results in increased phosphorylation of MAPK9 protein CTD PMID:27282967 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO ebselen inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA] CTD PMID:11903743 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Ngf nerve growth factor multiple interactions EXP ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:20495008 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
decreases activity
EXP
ISO
ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
ebselen results in decreased activity of NOS2 protein
CTD PMID:7590103 PMID:12794164 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 decreases activity ISO ebselen results in decreased activity of NQO1 protein CTD PMID:7590103 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions EXP [ebselen co-treated with Glucose] results in increased expression of PDX1 protein CTD PMID:23795780 NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658
JBrowse link
G Phospho1 phosphatase, orphan 1 decreases activity ISO ebselen results in decreased activity of PHOSPHO1 protein CTD PMID:17227223 NCBI chr11:95,715,326...95,722,966
Ensembl chr11:95,715,325...95,722,966
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein] CTD PMID:14572605 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 multiple interactions ISO ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron] CTD PMID:16984886 NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953
JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 multiple interactions EXP
ISO
[ebselen co-treated with Glucose] results in increased expression of SLC2A2 protein
ebselen inhibits the reaction [Cisplatin results in increased expression of SLC2A2 protein]
CTD PMID:23795780 PMID:32860823 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21131394 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276
JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases response to substance
multiple interactions
ISO
EXP
ebselen results in decreased susceptibility to SOD1 protein mutant form
ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
CTD PMID:16702190 PMID:23795780 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:20495008 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Tat tyrosine aminotransferase multiple interactions ISO ebselen inhibits the reaction [Cisplatin results in increased activity of TAT protein] CTD PMID:32860823 NCBI chr 8:110,712,710...110,726,436
Ensembl chr 8:110,717,069...110,726,435
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]
ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
CTD PMID:11903743 PMID:16757516 PMID:21131394 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] CTD PMID:11903743 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ebselen inhibits the reaction [sodium arsenite results in increased expression of TNF protein] CTD PMID:30558456 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO ebselen results in increased expression of and results in increased activity of TXNRD1 protein CTD PMID:28383113 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions EXP [ebselen co-treated with Glucose] results in decreased expression of UCP2 protein CTD PMID:23795780 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227
JBrowse link
G Xbp1 X-box binding protein 1 increases phosphorylation ISO ebselen results in increased phosphorylation of XBP1 protein CTD PMID:27282967 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
JBrowse link
G Xpa xeroderma pigmentosum, complementation group A multiple interactions ISO ebselen inhibits the reaction [Zinc binds to XPA protein] CTD PMID:15265038 NCBI chr 4:46,175,222...46,196,317
Ensembl chr 4:46,155,347...46,196,311
JBrowse link
N-ethylmaleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases activity ISO Ethylmaleimide results in decreased activity of ABCB1 protein CTD PMID:2900677 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 affects activity
multiple interactions
ISO Ethylmaleimide affects the activity of ABCC1 protein
Ethylmaleimide inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
CTD PMID:9096673 PMID:9334814 PMID:16101123 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases activity ISO Ethylmaleimide results in decreased activity of ACSL4 protein CTD PMID:11319222 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531
JBrowse link
G Alb albumin decreases transport ISO Ethylmaleimide results in decreased transport of ALB protein CTD PMID:15897811 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596
JBrowse link
G Atp7a ATPase, copper transporting, alpha polypeptide multiple interactions
increases glutathionylation
ISO Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:105,070,830...105,171,766
Ensembl chr  X:105,070,882...105,168,532
JBrowse link
G Atp8b1 ATPase, class I, type 8B, member 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines] CTD PMID:11584374 NCBI chr18:64,662,050...64,794,342
Ensembl chr18:64,662,038...64,794,338
JBrowse link
G Cbr2 carbonyl reductase 2 increases acylation EXP Ethylmaleimide results in increased acylation of CBR2 protein CTD PMID:18597497 NCBI chr11:120,620,311...120,622,851
Ensembl chr11:120,620,315...120,622,940
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767
JBrowse link
G Chat choline O-acetyltransferase decreases activity EXP Ethylmaleimide results in decreased activity of CHAT protein CTD PMID:3437937 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions EXP Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] CTD PMID:10820281 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
JBrowse link
G Dusp23 dual specificity phosphatase 23 multiple interactions ISO Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr 1:172,458,336...172,460,504
Ensembl chr 1:172,458,331...172,460,529
JBrowse link
G F3 coagulation factor III increases expression ISO Ethylmaleimide results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases activity ISO Ethylmaleimide results in decreased activity of GAD1 protein CTD PMID:15836621 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
JBrowse link
G Gad2 glutamic acid decarboxylase 2 decreases activity ISO Ethylmaleimide results in decreased activity of GAD2 protein CTD PMID:15836621 NCBI chr 2:22,512,262...22,583,889
Ensembl chr 2:22,512,217...22,583,886
JBrowse link
G Hoxb13 homeobox B13 increases response to substance ISO HOXB13 protein results in increased susceptibility to Ethylmaleimide CTD PMID:24213000 NCBI chr11:96,085,142...96,087,436
Ensembl chr11:96,085,142...96,088,273
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein] CTD PMID:22796344 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620
JBrowse link
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble multiple interactions
decreases activity
ISO isocitric acid inhibits the reaction [Ethylmaleimide results in decreased activity of IDH1 protein]; NADP promotes the reaction [Ethylmaleimide results in decreased activity of IDH1 protein] CTD PMID:8486157 NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Ltbr lymphotoxin B receptor multiple interactions ISO Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr 6:125,283,534...125,291,026
Ensembl chr 6:125,283,534...125,290,848
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mt3 metallothionein 3 increases alkylation ISO Ethylmaleimide results in increased alkylation of MT3 protein CTD PMID:12383939 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774
JBrowse link
G Osm oncostatin M multiple interactions ISO Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr11:4,186,831...4,191,027
Ensembl chr11:4,186,420...4,191,026
JBrowse link
G Pah phenylalanine hydroxylase multiple interactions EXP Ethylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] CTD PMID:19367645 NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998
JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein] CTD PMID:26060329 NCBI chr15:97,936,625...97,991,625
Ensembl chr15:97,936,625...97,991,625
JBrowse link
G Senp6 SUMO/sentrin specific peptidase 6 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr 9:79,973,862...80,052,064
Ensembl chr 9:79,974,185...80,052,235
JBrowse link
G Slc12a5 solute carrier family 12, member 5 increases activity
multiple interactions
ISO Ethylmaleimide results in increased activity of SLC12A5 protein
Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]
CTD PMID:20086212 NCBI chr 2:164,802,766...164,841,651
Ensembl chr 2:164,802,722...164,841,651
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 3:104,545,980...104,565,778
Ensembl chr 3:104,545,984...104,565,778
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions EXP
ISO
Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839
JBrowse link
G Sumo2 small ubiquitin-like modifier 2 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]; Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr11:115,413,935...115,427,056
Ensembl chr11:115,413,928...115,427,102
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trf transferrin decreases uptake EXP Ethylmaleimide results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
JBrowse link
G Vdac1 voltage-dependent anion channel 1 affects binding ISO Ethylmaleimide binds to VDAC1 protein CTD PMID:20192921 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
decreases activity
ISO Dithiothreitol promotes the reaction [Ethylmaleimide results in decreased activity of VKORC1 protein] CTD PMID:2319331 NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22327
    role 22313
      biological role 22312
        biochemical role 21543
          enzyme inhibitor 19934
            EC 1.* (oxidoreductase) inhibitor 18035
              EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor 6732
                EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor 3192
                  EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor 90
                    N-ethylmaleimide 36
                    ebselen 57
paths to the root