|
G |
ACTA2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] |
CTD |
PMID:16757516 |
|
NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339
|
|
G |
ADAM9 |
ADAM metallopeptidase domain 9 |
multiple interactions |
EXP |
ebselen inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein] |
CTD |
PMID:17018608 |
|
NCBI chr 8:38,996,973...39,105,261
Ensembl chr 8:38,996,754...39,105,445
|
|
G |
AFP |
alpha fetoprotein |
multiple interactions |
ISO |
ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA] |
CTD |
PMID:11133813 |
|
NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
|
|
G |
ALAD |
aminolevulinate dehydratase |
multiple interactions decreases activity |
ISO |
Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein] ebselen inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein] |
CTD |
PMID:14630126 PMID:17624921 PMID:23933410 |
|
NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
|
|
G |
ALOX5 |
arachidonate 5-lipoxygenase |
decreases activity |
EXP |
ebselen results in decreased activity of ALOX5 protein |
CTD |
PMID:7590103 |
|
NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
|
|
G |
BAX |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
ebselen inhibits the reaction [sodium arsenite results in increased expression of BAX protein] |
CTD |
PMID:30558456 |
|
NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
|
|
G |
BCL2 |
BCL2 apoptosis regulator |
multiple interactions |
ISO |
ebselen inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein] |
CTD |
PMID:30558456 |
|
NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
|
|
G |
CASP3 |
caspase 3 |
multiple interactions increases activity |
EXP ISO |
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP3 protein] ebselen results in increased activity of CASP3 protein ebselen inhibits the reaction [Methylmercury Compounds results in increased activity of CASP3 protein]; ebselen inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein] |
CTD |
PMID:21300091 PMID:23649643 PMID:25068500 PMID:30558456 |
|
NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
|
|
G |
CASP9 |
caspase 9 |
multiple interactions |
EXP ISO |
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP9 protein] ebselen inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein] |
CTD |
PMID:18629305 PMID:23649643 |
|
NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
|
|
G |
CAT |
catalase |
increases activity multiple interactions |
ISO |
ebselen results in increased activity of CAT protein ebselen inhibits the reaction [sodium arsenite results in decreased activity of CAT protein] |
CTD |
PMID:27282967 PMID:30558456 |
|
NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
|
|
G |
COX4I1 |
cytochrome c oxidase subunit 4I1 |
increases expression |
EXP |
ebselen results in increased expression of COX4I1 protein |
CTD |
PMID:27385396 |
|
NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068
|
|
G |
CS |
citrate synthase |
multiple interactions |
EXP ISO |
ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein] ebselen inhibits the reaction [Cisplatin results in decreased activity of CS protein] |
CTD |
PMID:27385396 PMID:32860823 |
|
NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391
|
|
G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
multiple interactions |
EXP |
ebselen inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; ebselen inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; ebselen inhibits the reaction [Peroxynitrous Acid results in increased expression of CXCL8 mRNA]; ebselen inhibits the reaction [Peroxynitrous Acid results in increased expression of CXCL8 protein] |
CTD |
PMID:14572605 |
|
NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
|
|
G |
CYP2E1 |
cytochrome P450 family 2 subfamily E member 1 |
multiple interactions |
ISO |
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA] |
CTD |
PMID:11903743 |
|
NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
|
|
G |
EIF2S1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation |
ISO |
ebselen results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:27282967 |
|
NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
|
|
G |
EPHX2 |
epoxide hydrolase 2 |
multiple interactions |
EXP |
ebselen binds to and results in decreased activity of EPHX2 protein |
CTD |
PMID:23219563 |
|
NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564
|
|
G |
FMR1 |
fragile X messenger ribonucleoprotein 1 |
multiple interactions |
EXP |
ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein] |
CTD |
PMID:27385396 |
|
NCBI chr X:147,911,919...147,951,125
Ensembl chr X:147,911,919...147,951,125
|
|
G |
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] |
CTD |
PMID:14572605 |
|
NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190
|
|
G |
G6PC1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions |
ISO |
ebselen inhibits the reaction [Cisplatin results in increased activity of G6PC1 protein] |
CTD |
PMID:32860823 |
|
NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
|
|
G |
GCK |
glucokinase |
multiple interactions |
ISO |
[ebselen co-treated with Glucose] results in increased activity of GCK protein |
CTD |
PMID:23795780 |
|
NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170
|
|
G |
GFAP |
glial fibrillary acidic protein |
increases phosphorylation |
ISO |
ebselen results in increased phosphorylation of GFAP protein |
CTD |
PMID:27282967 |
|
NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
|
|
G |
GJA1 |
gap junction protein alpha 1 |
multiple interactions |
ISO |
ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]; ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein] |
CTD |
PMID:12958040 |
|
NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
|
|
G |
GPX1 |
glutathione peroxidase 1 |
multiple interactions |
ISO EXP |
ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]] ebselen inhibits the reaction [Methylmercury Compounds results in decreased activity of GPX1 protein] |
CTD |
PMID:23795780 PMID:28383113 |
|
NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
|
|
G |
GSR |
glutathione-disulfide reductase |
increases activity multiple interactions |
ISO |
ebselen results in increased activity of GSR protein ebselen inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] |
CTD |
PMID:27282967 PMID:30558456 |
|
NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
|
|
G |
GSTA1 |
glutathione S-transferase alpha 1 |
multiple interactions |
ISO |
ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein] |
CTD |
PMID:8147899 |
|
NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860
|
|
G |
GSTM1 |
glutathione S-transferase mu 1 |
multiple interactions |
ISO |
ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein] |
CTD |
PMID:8147899 |
|
NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
|
|
G |
GSTM2 |
glutathione S-transferase mu 2 |
multiple interactions |
ISO |
ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein] |
CTD |
PMID:8147899 |
|
NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
|
|
G |
GSTP1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
ebselen binds to and results in decreased activity of GSTP1 protein |
CTD |
PMID:8147899 |
|
NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
|
|
G |
HIF1A |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
EXP |
ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]] |
CTD |
PMID:19374849 |
|
NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
|
|
G |
HMOX1 |
heme oxygenase 1 |
multiple interactions |
ISO |
[ebselen affects the abundance of Reactive Oxygen Species] which results in decreased expression of HMOX1 protein; [ebselen affects the abundance of Reactive Oxygen Species] which results in increased activity of HMOX1 protein |
CTD |
PMID:16959961 |
|
NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
|
|
G |
HPGDS |
hematopoietic prostaglandin D synthase |
increases expression |
ISO |
ebselen results in increased expression of HPGDS mRNA |
CTD |
PMID:21669866 |
|
NCBI chr 4:94,298,535...94,342,836
Ensembl chr 4:94,298,535...94,342,876
|
|
G |
HSF1 |
heat shock transcription factor 1 |
increases activity |
EXP |
ebselen results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
|
NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720
|
|
G |
IFNG |
interferon gamma |
multiple interactions |
ISO |
ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] |
CTD |
PMID:12794164 |
|
NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
|
|
G |
IL6 |
interleukin 6 |
multiple interactions |
ISO |
ebselen inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] |
CTD |
PMID:30558456 |
|
NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
|
|
G |
INS-IGF2 |
INS-IGF2 readthrough |
multiple interactions |
ISO |
ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen promotes the reaction [Glucose results in increased secretion of INS1 protein] |
CTD |
PMID:23795780 |
|
NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
|
|
G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions increases activity increases phosphorylation |
ISO |
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] ebselen results in increased activity of MAPK1 protein ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK1 protein] ebselen analog results in increased phosphorylation of MAPK1 protein; ebselen results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 |
|
NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
|
|
G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions increases activity increases phosphorylation |
ISO |
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] ebselen results in increased activity of MAPK3 protein ebselen analog results in increased phosphorylation of MAPK3 protein; ebselen results in increased phosphorylation of MAPK3 protein ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK3 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 |
|
NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
|
|
G |
MAPK9 |
mitogen-activated protein kinase 9 |
increases phosphorylation |
ISO |
ebselen results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:27282967 |
|
NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
|
|
G |
MMP13 |
matrix metallopeptidase 13 |
multiple interactions |
ISO |
ebselen inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA] |
CTD |
PMID:11903743 |
|
NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
|
|
G |
NGF |
nerve growth factor |
multiple interactions |
ISO |
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:20495008 |
|
NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770
|
|
G |
NOS2 |
nitric oxide synthase 2 |
multiple interactions decreases activity |
ISO |
ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] ebselen results in decreased activity of NOS2 protein |
CTD |
PMID:7590103 PMID:12794164 |
|
NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
|
|
G |
NQO1 |
NAD(P)H quinone dehydrogenase 1 |
decreases activity |
ISO |
ebselen results in decreased activity of NQO1 protein |
CTD |
PMID:7590103 |
|
NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
|
|
G |
PDX1 |
pancreatic and duodenal homeobox 1 |
multiple interactions |
ISO |
[ebselen co-treated with Glucose] results in increased expression of PDX1 protein |
CTD |
PMID:23795780 |
|
NCBI chr13:27,920,000...27,926,313
Ensembl chr13:27,920,000...27,926,313
|
|
G |
PHOSPHO1 |
phosphoethanolamine/phosphocholine phosphatase 1 |
decreases activity |
EXP |
ebselen results in decreased activity of PHOSPHO1 protein |
CTD |
PMID:17227223 |
|
NCBI chr17:49,223,366...49,230,787
Ensembl chr17:49,223,366...49,230,787
|
|
G |
RELA |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein] |
CTD |
PMID:14572605 |
|
NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
|
|
G |
SLC11A2 |
solute carrier family 11 member 2 |
multiple interactions |
EXP |
ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron] |
CTD |
PMID:16984886 |
|
NCBI chr12:50,952,263...51,028,886
Ensembl chr12:50,979,401...51,028,566
|
|
G |
SLC2A2 |
solute carrier family 2 member 2 |
multiple interactions |
ISO |
[ebselen co-treated with Glucose] results in increased expression of SLC2A2 protein ebselen inhibits the reaction [Cisplatin results in increased expression of SLC2A2 protein] |
CTD |
PMID:23795780 PMID:32860823 |
|
NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743
|
|
G |
SMAD3 |
SMAD family member 3 |
multiple interactions |
EXP |
ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:21131394 |
|
NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173
|
|
G |
SOD1 |
superoxide dismutase 1 |
decreases response to substance multiple interactions |
EXP ISO |
ebselen results in decreased susceptibility to SOD1 protein mutant form ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]] |
CTD |
PMID:16702190 PMID:23795780 |
|
NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
|
|
G |
SOD2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:20495008 |
|
NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
|
|
G |
TAT |
tyrosine aminotransferase |
multiple interactions |
ISO |
ebselen inhibits the reaction [Cisplatin results in increased activity of TAT protein] |
CTD |
PMID:32860823 |
|
NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092
|
|
G |
TGFB1 |
transforming growth factor beta 1 |
multiple interactions |
ISO EXP |
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:11903743 PMID:16757516 PMID:21131394 |
|
NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
|
|
G |
TIMP1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
ISO |
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] |
CTD |
PMID:11903743 |
|
NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789
|
|
G |
TNF |
tumor necrosis factor |
multiple interactions |
ISO |
ebselen inhibits the reaction [sodium arsenite results in increased expression of TNF protein] |
CTD |
PMID:30558456 |
|
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
|
|
G |
TXNRD1 |
thioredoxin reductase 1 |
multiple interactions |
EXP |
ebselen results in increased expression of and results in increased activity of TXNRD1 protein |
CTD |
PMID:28383113 |
|
NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
|
|
G |
UCP2 |
uncoupling protein 2 |
multiple interactions |
ISO |
[ebselen co-treated with Glucose] results in decreased expression of UCP2 protein |
CTD |
PMID:23795780 |
|
NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,061...73,982,843
|
|
G |
XBP1 |
X-box binding protein 1 |
increases phosphorylation |
ISO |
ebselen results in increased phosphorylation of XBP1 protein |
CTD |
PMID:27282967 |
|
NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
|
|
G |
XPA |
XPA, DNA damage recognition and repair factor |
multiple interactions |
EXP |
ebselen inhibits the reaction [Zinc binds to XPA protein] |
CTD |
PMID:15265038 |
|
NCBI chr 9:97,654,398...97,697,340
Ensembl chr 9:97,674,909...97,697,340
|
|
|
G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
decreases activity |
EXP |
Ethylmaleimide results in decreased activity of ABCB1 protein |
CTD |
PMID:2900677 |
|
NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
|
|
G |
ABCC1 |
ATP binding cassette subfamily C member 1 (ABCC1 blood group) |
affects activity multiple interactions |
EXP |
Ethylmaleimide affects the activity of ABCC1 protein Ethylmaleimide inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] |
CTD |
PMID:9096673 PMID:9334814 PMID:16101123 |
|
NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
|
|
G |
ACSL4 |
acyl-CoA synthetase long chain family member 4 |
decreases activity |
ISO |
Ethylmaleimide results in decreased activity of ACSL4 protein |
CTD |
PMID:11319222 |
|
NCBI chr X:109,641,335...109,733,257
Ensembl chr X:109,624,244...109,733,403
|
|
G |
ALB |
albumin |
decreases transport |
ISO |
Ethylmaleimide results in decreased transport of ALB protein |
CTD |
PMID:15897811 |
|
NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
|
|
G |
APEX1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
multiple interactions |
EXP |
Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] |
CTD |
PMID:23370007 |
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NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
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G |
ATP7A |
ATPase copper transporting alpha |
multiple interactions increases glutathionylation |
EXP |
Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] |
CTD |
PMID:20566629 |
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NCBI chr X:77,910,693...78,050,395
Ensembl chr X:77,910,690...78,050,395
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G |
ATP8B1 |
ATPase phospholipid transporting 8B1 |
multiple interactions |
ISO |
Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines] |
CTD |
PMID:11584374 |
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NCBI chr18:57,646,426...57,803,315
Ensembl chr18:57,646,426...57,803,315
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G |
CFTR |
CF transmembrane conductance regulator |
multiple interactions |
EXP |
Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] |
CTD |
PMID:15657297 |
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NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
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G |
CHAT |
choline O-acetyltransferase |
decreases activity |
ISO |
Ethylmaleimide results in decreased activity of CHAT protein |
CTD |
PMID:3437937 |
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NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
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G |
CHUK |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] |
CTD |
PMID:10820281 |
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NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596
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G |
DUSP23 |
dual specificity phosphatase 23 |
multiple interactions |
EXP |
Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] |
CTD |
PMID:15147733 |
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NCBI chr 1:159,780,962...159,782,543
Ensembl chr 1:159,780,932...159,782,543
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G |
F3 |
coagulation factor III, tissue factor |
increases expression |
EXP |
Ethylmaleimide results in increased expression of F3 protein |
CTD |
PMID:25569083 |
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NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
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G |
GAD1 |
glutamate decarboxylase 1 |
decreases activity |
EXP |
Ethylmaleimide results in decreased activity of GAD1 protein |
CTD |
PMID:15836621 |
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NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
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G |
GAD2 |
glutamate decarboxylase 2 |
decreases activity |
EXP |
Ethylmaleimide results in decreased activity of GAD2 protein |
CTD |
PMID:15836621 |
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NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558
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G |
HOXB13 |
homeobox B13 |
increases response to substance |
EXP |
HOXB13 protein results in increased susceptibility to Ethylmaleimide |
CTD |
PMID:24213000 |
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NCBI chr17:48,724,763...48,728,750
Ensembl chr17:48,724,763...48,728,750
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G |
HSD11B2 |
hydroxysteroid 11-beta dehydrogenase 2 |
multiple interactions |
EXP |
Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein] |
CTD |
PMID:22796344 |
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NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553
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G |
IDH1 |
isocitrate dehydrogenase (NADP(+)) 1 |
multiple interactions decreases activity |
ISO |
isocitric acid inhibits the reaction [Ethylmaleimide results in decreased activity of IDH1 protein]; NADP promotes the reaction [Ethylmaleimide results in decreased activity of IDH1 protein] |
CTD |
PMID:8486157 |
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NCBI chr 2:208,236,227...208,255,071
Ensembl chr 2:208,236,229...208,266,074
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G |
IL1A |
interleukin 1 alpha |
multiple interactions |
EXP |
Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] |
CTD |
PMID:7476933 |
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NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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G |
LTBR |
lymphotoxin beta receptor |
multiple interactions |
EXP |
Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] |
CTD |
PMID:37193757 |
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NCBI chr12:6,375,160...6,391,566
Ensembl chr12:6,375,045...6,391,571
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions |
EXP |
Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] |
CTD |
PMID:23370007 |
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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G |
MT3 |
metallothionein 3 |
increases alkylation |
EXP |
Ethylmaleimide results in increased alkylation of MT3 protein |
CTD |
PMID:12383939 |
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NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
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G |
OSM |
oncostatin M |
multiple interactions |
EXP |
Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] |
CTD |
PMID:37193757 |
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NCBI chr22:30,262,829...30,266,851
Ensembl chr22:30,262,829...30,266,851
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G |
PAH |
phenylalanine hydroxylase |
multiple interactions |
ISO |
Ethylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] |
CTD |
PMID:19367645 |
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NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
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G |
SENP1 |
SUMO specific peptidase 1 |
multiple interactions |
EXP |
Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein] |
CTD |
PMID:26060329 |
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NCBI chr12:48,042,897...48,106,079
Ensembl chr12:48,039,784...48,106,079
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G |
SENP6 |
SUMO specific peptidase 6 |
multiple interactions |
EXP |
Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] |
CTD |
PMID:26060329 |
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NCBI chr 6:75,601,880...75,718,281
Ensembl chr 6:75,601,509...75,718,281
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G |
SLC12A5 |
solute carrier family 12 member 5 |
increases activity multiple interactions |
EXP |
Ethylmaleimide results in increased activity of SLC12A5 protein Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium] |
CTD |
PMID:20086212 |
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NCBI chr20:46,021,686...46,060,150
Ensembl chr20:46,021,690...46,060,150
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G |
SLC16A1 |
solute carrier family 16 member 1 |
multiple interactions |
EXP |
Ethylmaleimide inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] |
CTD |
PMID:15804185 |
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NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593
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G |
SOD2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] |
CTD |
PMID:7476933 |
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NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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G |
SP1 |
Sp1 transcription factor |
multiple interactions |
ISO EXP |
Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] |
CTD |
PMID:9343396 |
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NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
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G |
SUMO2 |
small ubiquitin like modifier 2 |
multiple interactions |
EXP |
Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]; Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] |
CTD |
PMID:26060329 |
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NCBI chr17:75,165,586...75,182,959
Ensembl chr17:75,165,586...75,182,959
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G |
TF |
transferrin |
decreases uptake |
ISO |
Ethylmaleimide results in decreased uptake of TF protein |
CTD |
PMID:10865941 |
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NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641
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G |
TH |
tyrosine hydroxylase |
multiple interactions |
ISO |
Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] |
CTD |
PMID:15983997 |
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NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
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G |
TNF |
tumor necrosis factor |
multiple interactions |
EXP |
Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] |
CTD |
PMID:7476933 |
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
VDAC1 |
voltage dependent anion channel 1 |
affects binding |
ISO |
Ethylmaleimide binds to VDAC1 protein |
CTD |
PMID:20192921 |
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NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975
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G |
VKORC1 |
vitamin K epoxide reductase complex subunit 1 |
decreases activity multiple interactions |
ISO |
Ethylmaleimide results in decreased activity of VKORC1 protein Dithiothreitol promotes the reaction [Ethylmaleimide results in decreased activity of VKORC1 protein] |
CTD |
PMID:2319331 |
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NCBI chr16:31,090,854...31,094,797
Ensembl chr16:31,090,842...31,095,980
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