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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:asarone
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Accession:CHEBI:78308 term browser browse the term
Definition:A phenylpropanoid that is benzene substituted by methoxy groups at positions 1, 2 and 4 and a propen-1-yl group at position 5. It has been isolated from Acorus.
Synonyms:exact_synonym: 1,2,4-trimethoxy-5-(prop-1-en-1-yl)benzene
 related_synonym: 2,4,5-trimethoxy-1-propenylbenzene;   Formula=C12H16O3;   InChI=1S/C12H16O3/c1-5-6-9-7-11(14-3)12(15-4)8-10(9)13-2/h5-8H,1-4H3;   InChIKey=RKFAZBXYICVSKP-UHFFFAOYSA-N;   SMILES=COc1cc(OC)c(C=CC)cc1OC
 xref_mesh: MESH:C012195
 xref: Reaxys:2210026


show annotations for term's descendants           Sort by:
asarone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity-regulated cytoskeleton-associated protein multiple interactions EXP asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of ARC mRNA]; asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of ARC protein] CTD PMID:27936013 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO asarone results in increased expression of BAX mRNA CTD PMID:29174417 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO asarone results in decreased expression of BCL2 mRNA CTD PMID:29174417 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp8 caspase 8 increases activity ISO asarone results in increased activity of CASP8 protein CTD PMID:29174417 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GRIN2B protein] CTD PMID:27936013 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:25066769 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:25066769 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:25066769 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; asarone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:25066769 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; asarone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:25066769 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:25066769 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:25066769 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Wnt7a Wnt family member 7A multiple interactions EXP asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of WNT7A mRNA]; asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of WNT7A protein] CTD PMID:27936013 NCBI chr 4:125,420,276...125,466,149
Ensembl chr 4:125,420,276...125,466,149 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      biological role 20805
        biochemical role 20268
          metabolite 20237
            eukaryotic metabolite 19962
              plant metabolite 18270
                asarone 13
                  alpha-asarone 0
                  beta-asarone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20403
                                carbocyclic compound 18975
                                  benzenoid aromatic compound 18456
                                    benzenes 18309
                                      alkenylbenzene 1328
                                        asarone 13
                                          alpha-asarone 0
                                          beta-asarone 0
paths to the root