Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iron dextran
go back to main search page
Accession:CHEBI:78291 term browser browse the term
Definition:Please consider adding concept for iron dextran. CAS# 9004-66-4. Thank you.
Synonyms:related_synonym: Iron dextran complex
 xref: CAS:9004-66-4;   KEGG:C13774;   KEGG:D02141
 xref_mesh: MESH:D007505


show annotations for term's descendants           Sort by:
iron dextran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression ISO Iron-Dextran Complex results in increased expression of ACSL4 protein CTD PMID:38056807 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:110,739,648...110,803,261 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [ADIPOQ protein results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; GW 6471 inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; Iron-Dextran Complex inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; tin protoporphyrin IX promotes the reaction [Iron-Dextran Complex inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]] CTD PMID:20709802 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Iron-Dextran Complex affects the reaction [AHR affects the susceptibility to Tetrachlorodibenzodioxin] CTD PMID:9443932 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein] CTD PMID:32828744 PMID:33580994 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		ISO
EXP 		3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; SB 203580 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]
Iron-Dextran Complex results in increased expression of BAX protein
chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of BAX protein] 		CTD PMID:33285147 PMID:33393188 PMID:38432408 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		ISO
EXP 		[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein]
chrysin inhibits the reaction [Iron-Dextran Complex results in decreased expression of BCL2 protein] 		CTD PMID:33285147 PMID:38432408 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression 		ISO [ADIPOQ protein results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; [pirinixic acid results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; Bilirubin promotes the reaction [Iron-Dextran Complex results in increased expression of BCL2L1 protein] CTD PMID:20709802 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression EXP Iron-Dextran Complex results in decreased expression of BGLAP mRNA CTD PMID:29122540 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions
affects expression 		ISO Diltiazem inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]; Nimodipine inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]; Verapamil inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein] 		CTD PMID:27095094 PMID:33285147 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762 		JBrowse link
G Casp1 caspase 1 increases expression
multiple interactions 		EXP Iron-Dextran Complex results in increased expression of CASP1 protein
chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP1 protein] 		CTD PMID:38432408 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression 		ISO
EXP 		[ADIPOQ protein results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CASP3 protein; [pirinixic acid results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; Bilirubin inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; GW 6471 inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; tin protoporphyrin IX inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein; chrysin inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein]
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein; Arginine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]; U 0126 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein] 		CTD PMID:20709802 PMID:32135237 PMID:32828744 PMID:33285147 PMID:33393188 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity
increases expression 		ISO
EXP 		Iron-Dextran Complex promotes the reaction [Benzoyl Peroxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [mezerein results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
Iron-Dextran Complex results in increased activity of CAT protein
Iron-Dextran Complex results in decreased activity of CAT protein
Iron-Dextran Complex results in increased expression of CAT protein
Arginine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]; Cyclosporine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]]; Edaravone inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased activity of CAT protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased activity of CAT protein] 		CTD PMID:12065085 PMID:24120471 PMID:28700905 PMID:32135237 PMID:33580994 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein] CTD PMID:33285147 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions 		ISO Iron-Dextran Complex results in increased expression of COL1A1 protein
Diltiazem inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein]; Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein]; Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein] 		CTD PMID:27095094 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CTSK protein; Acetylcysteine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CTSK protein]; Deferoxamine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CTSK protein] CTD PMID:38971422 NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582 		JBrowse link
G Cyba cytochrome b-245 alpha chain increases expression EXP Iron-Dextran Complex results in increased expression of CYBA protein CTD PMID:15086920 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214 		JBrowse link
G Cybb cytochrome b-245 beta chain increases expression EXP Iron-Dextran Complex results in increased expression of CYBB protein CTD PMID:28700905 PMID:29990562 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity 		ISO Iron-Dextran Complex inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Iron-Dextran Complex results in decreased activity of CYP1A1 protein 		CTD PMID:9443932 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity 		ISO Iron-Dextran Complex inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
Iron-Dextran Complex results in decreased activity of CYP1A2 protein 		CTD PMID:9443932 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Ddah2 DDAH family member 2, ADMA-independent multiple interactions
decreases expression 		ISO [Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine; Arginine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine]; Arginine inhibits the reaction [Iron-Dextran Complex results in decreased expression of DDAH2 protein]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased abundance of Nitric Oxide]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of Malondialdehyde]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of N,N-dimethylarginine]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of Reactive Oxygen Species]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]]; tetramethylpyrazine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased expression of DDAH2 protein] CTD PMID:32135237 NCBI chr20:3,766,115...3,769,161
Ensembl chr20:3,766,120...3,769,183 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation 		EXP [Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein; bergenin inhibits the reaction [Iron-Dextran Complex results in increased phosphorylation of FOS protein]; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein] CTD PMID:32828744 PMID:33580994 PMID:36207002 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
increases expression 		ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein; Deferoxamine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein]; Deferoxamine inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]; Diltiazem inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]; Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]; Resveratrol inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]; Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein] 		CTD PMID:27095094 PMID:33285147 PMID:33393188 PMID:34044072 PMID:38971422 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions
increases expression 		EXP chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of GOT1 protein] CTD PMID:38432408 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression 		EXP [Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein; chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of GPT protein]; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein] CTD PMID:32828744 PMID:33580994 PMID:38432408 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO Iron-Dextran Complex results in decreased expression of GPX4 protein CTD PMID:38056807 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GSR protein CTD PMID:33393188 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases expression 		ISO [Iron-Dextran Complex co-treated with Tetrachlorodibenzodioxin] results in increased expression of GSTM1 protein
Iron-Dextran Complex results in increased expression of GSTM1 protein 		CTD PMID:9443932 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
increases expression 		ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of HAMP mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of HAMP protein; Deferoxamine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of HAMP protein]; Diltiazem promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]; Nimodipine promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]; Verapamil promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA] CTD PMID:27095094 PMID:33393188 PMID:38971422 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression 		ISO
EXP 		Iron-Dextran Complex inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]; tin protoporphyrin IX promotes the reaction [Iron-Dextran Complex inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]]
Iron-Dextran Complex results in increased expression of HMOX1 mRNA; Iron-Dextran Complex results in increased expression of HMOX1 protein 		CTD PMID:20709802 PMID:23525258 PMID:38432408 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression 		EXP [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein; bergenin inhibits the reaction [Iron-Dextran Complex results in increased expression of IL1B protein]; chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of IL1B protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein] CTD PMID:32828744 PMID:36207002 PMID:38432408 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions 		EXP
ISO 		Iron-Dextran Complex results in increased expression of IL6 mRNA; Iron-Dextran Complex results in increased expression of IL6 protein
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein; chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of IL6 protein]; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein] 		CTD PMID:29122540 PMID:32828744 PMID:33285147 PMID:33580994 PMID:38432408 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions 		EXP
ISO 		Iron-Dextran Complex results in increased phosphorylation of MAPK1 protein
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein] 		CTD PMID:28700905 PMID:33285147 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions 		EXP
ISO 		Iron-Dextran Complex results in increased phosphorylation of MAPK3 protein
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein] 		CTD PMID:28700905 PMID:33285147 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of MMP9 protein; Acetylcysteine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of MMP9 protein]; Deferoxamine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of MMP9 protein] CTD PMID:38971422 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases expression 		EXP chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of MPO protein] CTD PMID:38432408 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression EXP Iron-Dextran Complex results in increased expression of NFE2L2 protein CTD PMID:38432408 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein] CTD PMID:33285147 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression 		EXP chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of NLRP3 protein] CTD PMID:38432408 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Iron-Dextran Complex results in increased expression of NOS2 protein CTD PMID:28700905 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases phosphorylation 		EXP
ISO 		Iron-Dextran Complex results in increased expression of and results in increased phosphorylation of NOS3 protein
Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein
Arginine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein] 		CTD PMID:29990562 PMID:32135237 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity 		ISO Iron-Dextran Complex promotes the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [Hydrogen Peroxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [mezerein results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]
Iron-Dextran Complex results in increased activity of ODC1 protein 		CTD PMID:12065085 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [taxifolin co-treated with [Iron-Dextran Complex results in increased abundance of Iron]] results in increased expression of PCNA protein CTD PMID:32828744 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions EXP [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of PIK3CA protein; [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of PIK3CA protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein] CTD PMID:32828744 PMID:33580994 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression 		EXP bergenin inhibits the reaction [Iron-Dextran Complex results in decreased expression of PPARG protein]; chrysin inhibits the reaction [Iron-Dextran Complex results in decreased expression of PPARG protein] CTD PMID:36207002 PMID:38432408 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions 		EXP Iron-Dextran Complex results in increased expression of PTGS2 protein
bergenin inhibits the reaction [Iron-Dextran Complex results in increased expression of PTGS2 protein] 		CTD PMID:36207002 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression 		EXP chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of PYCARD protein] CTD PMID:38432408 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP 		[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; SB 203580 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; U 0126 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]
[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein; bergenin inhibits the reaction [Iron-Dextran Complex affects the localization of and results in increased expression of RELA protein]; chrysin inhibits the reaction [Iron-Dextran Complex results in increased localization of and results in increased acetylation of RELA protein]; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; Iron-Dextran Complex affects the localization of and results in increased expression of RELA protein; Iron-Dextran Complex results in increased localization of and results in increased acetylation of RELA protein 		CTD PMID:33285147 PMID:33580994 PMID:36207002 PMID:38432408 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rho rhodopsin multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RHO mRNA; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RHO mRNA] CTD PMID:33285147 NCBI chr 4:148,975,597...148,988,693
Ensembl chr 4:150,653,205...150,658,367 		JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RPE65 mRNA; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RPE65 mRNA] CTD PMID:33285147 NCBI chr 2:251,425,228...251,457,209
Ensembl chr 2:251,425,368...251,457,156 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression 		EXP chrysin inhibits the reaction [Iron-Dextran Complex results in decreased expression of SIRT1 protein] CTD PMID:38432408 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
increases expression 		ISO Diltiazem inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]; Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]; Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein] 		CTD PMID:27095094 PMID:33285147 NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA CTD PMID:33393188 NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:55,525,532...55,543,460 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Iron-Dextran Complex results in increased expression of SOD1 protein CTD PMID:29990562 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP Iron-Dextran Complex results in decreased expression of SOD2 protein CTD PMID:28700905 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Tfr2 transferrin receptor 2 increases expression ISO Iron-Dextran Complex results in increased expression of TFR2 protein CTD PMID:27095094 NCBI chr12:24,744,450...24,761,413
Ensembl chr12:24,744,450...24,761,413 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein] CTD PMID:33285147 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion EXP Iron-Dextran Complex results in increased secretion of TGFB1 protein CTD PMID:23525258 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		EXP
ISO 		[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein; bergenin inhibits the reaction [Iron-Dextran Complex results in increased expression of TNF protein]; chrysin inhibits the reaction [Iron-Dextran Complex results in increased expression of TNF protein]; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein] 		CTD PMID:32828744 PMID:33285147 PMID:33580994 PMID:36207002 PMID:38432408 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression EXP Iron-Dextran Complex results in decreased expression of TNFRSF11B mRNA CTD PMID:29122540 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075 		JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression
multiple interactions 		EXP
ISO 		Iron-Dextran Complex results in increased expression of TNFSF11 mRNA
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNFSF11; Acetylcysteine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNFSF11]; Deferoxamine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNFSF11] 		CTD PMID:29122540 PMID:38971422 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TXNIP mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TXNIP protein CTD PMID:33393188 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of TXNRD1 mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TXNRD1 protein CTD PMID:33393188 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Urod uroporphyrinogen decarboxylase multiple interactions ISO Iron-Dextran Complex promotes the reaction [Tetrachlorodibenzodioxin results in decreased activity of UROD protein] CTD PMID:9443932 NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:135,701,296...135,705,380 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          carbon atom 20710
            organic molecular entity 20710
              iron dextran 63
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            iron dextran 63
paths to the root