CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: food humectant
Accession: CHEBI:77969
browse the term
Definition: A humectant that is used as a food additive to prevent foodstuffs from drying out.
Synonyms: related_synonym: food humectants
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Akr1b1
aldo-keto reductase family 1 member B1
multiple interactions increases abundance
ISO
AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol] AKR1B1 protein results in increased abundance of Sorbitol
CTD
PMID:25451566 PMID:25541468
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Alox5
arachidonate 5-lipoxygenase
multiple interactions
ISO
[Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein; SB 203580 inhibits the reaction [Sorbitol results in increased activity of ALOX5 protein]; Sorbitol results in increased phosphorylation of and results in increased activity of ALOX5 protein
CTD
PMID:10779545 PMID:11698504
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Aqp9
aquaporin 9
multiple interactions increases uptake
ISO EXP
Sorbitol inhibits the reaction [AQP9 protein results in increased uptake of arsenite] AQP9 protein results in increased uptake of Sorbitol
CTD
PMID:9733774 PMID:19341753
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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Bola2
bolA family member 2
increases expression
ISO
Sorbitol results in increased expression of BOLA2 mRNA
CTD
PMID:35678645
NCBI chr 1:181,291,967...181,292,833
Ensembl chr 1:181,291,398...181,292,676
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Caprin1
cell cycle associated protein 1
multiple interactions
ISO
Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein]
CTD
PMID:33939924
NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
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Casp3
caspase 3
increases activity multiple interactions
EXP
Sorbitol results in increased activity of CASP3 protein Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]
CTD
PMID:20609311
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases activity multiple interactions
EXP
Sorbitol results in increased activity of CASP8 protein Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]
CTD
PMID:20609311
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity multiple interactions
EXP
Sorbitol results in increased activity of CASP9 protein Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]
CTD
PMID:20609311
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccna1
cyclin A1
decreases expression
ISO
Sorbitol results in decreased expression of CCNA1 mRNA
CTD
PMID:35678645
NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
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Ccnf
cyclin F
increases expression
ISO
Sorbitol results in increased expression of CCNF mRNA
CTD
PMID:35678645
NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
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Cdk1
cyclin-dependent kinase 1
decreases expression
ISO
Sorbitol results in decreased expression of CDK1 mRNA
CTD
PMID:35678645
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Chkb
choline kinase beta
decreases expression
ISO
Sorbitol results in decreased expression of CHKB mRNA
CTD
PMID:35678645
NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461
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Crk
CRK proto-oncogene, adaptor protein
increases phosphorylation
EXP
Sorbitol results in increased phosphorylation of CRK protein
CTD
PMID:16187300
NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
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Ddb1
damage-specific DNA binding protein 1
increases expression
ISO
Sorbitol results in increased expression of DDB1 mRNA
CTD
PMID:35678645
NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676
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Eef1d
eukaryotic translation elongation factor 1 delta
increases expression
ISO
Sorbitol results in increased expression of EEF1D mRNA
CTD
PMID:35678645
NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799
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Eif3h
eukaryotic translation initiation factor 3, subunit H
decreases expression
ISO
Sorbitol results in decreased expression of EIF3H mRNA
CTD
PMID:35678645
NCBI chr 7:83,091,037...83,174,451
Ensembl chr 7:83,091,039...83,174,451
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Eif4e
eukaryotic translation initiation factor 4E
multiple interactions
ISO
Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
CTD
PMID:9545260
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
multiple interactions
ISO
Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
CTD
PMID:9545260
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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Eny2
ENY2, transcription and export complex 2 subunit
increases expression
ISO
Sorbitol results in increased expression of ENY2 mRNA
CTD
PMID:35678645
NCBI chr 7:75,581,215...75,605,903
Ensembl chr 7:75,581,240...75,605,897
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Fmr1
fragile X messenger ribonucleoprotein 1
increases abundance
ISO
FMR1 5' UTR mutant form results in increased abundance of Sorbitol
CTD
PMID:27385396
NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050
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Ins1
insulin 1
multiple interactions
EXP
Sorbitol promotes the reaction [Glucose results in increased secretion of INS1 protein]
CTD
PMID:10221768
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases phosphorylation
ISO
JNK-IN-8 inhibits the reaction [Sorbitol results in increased phosphorylation of JUN protein]
CTD
PMID:24184208
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Mapk10
mitogen activated protein kinase 10
multiple interactions increases activity
ISO
Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein]
CTD
PMID:10531305
NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
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Mapk12
mitogen-activated protein kinase 12
increases phosphorylation
ISO
Sorbitol results in increased phosphorylation of MAPK12 protein
CTD
PMID:15362974
NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
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Mapk14
mitogen activated protein kinase 14
increases phosphorylation
ISO
Sorbitol results in increased phosphorylation of MAPK14 protein
CTD
PMID:15362974
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk7
mitogen-activated protein kinase 7
increases activity
ISO
Sorbitol results in increased activity of MAPK7 protein
CTD
PMID:11163183
NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
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Mapk8
mitogen-activated protein kinase 8
increases phosphorylation
ISO
Sorbitol results in increased phosphorylation of MAPK8 protein
CTD
PMID:24184208
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
increases phosphorylation
ISO
Sorbitol results in increased phosphorylation of MAPK9 protein
CTD
PMID:24184208
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Mapkapk2
MAPK activated protein kinase 2
increases activity increases phosphorylation multiple interactions
ISO
Sorbitol results in increased activity of MAPKAPK2 protein Sorbitol results in increased phosphorylation of MAPKAPK2 protein SB 203580 inhibits the reaction [Sorbitol results in increased phosphorylation of MAPKAPK2 protein]
CTD
PMID:9545260 PMID:15362974
NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
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Mknk1
MAPK interacting serine/threonine kinase 1
increases activity
ISO
Sorbitol results in increased activity of MKNK1 protein
CTD
PMID:9545260
NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639
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Mrps16
mitochondrial ribosomal protein S16
decreases expression
ISO
Sorbitol results in decreased expression of MRPS16 mRNA
CTD
PMID:35678645
NCBI chr15:3,918,621...3,921,024
Ensembl chr15:3,918,615...3,921,656
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Oat
ornithine aminotransferase
multiple interactions
EXP
Sorbitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]
CTD
PMID:2827574
NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
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Ppt1
palmitoyl-protein thioesterase 1
increases expression
ISO
Sorbitol results in increased expression of PPT1 mRNA
CTD
PMID:35678645
NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048
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Pten
phosphatase and tensin homolog
affects localization
ISO EXP
Sorbitol affects the localization of PTEN protein
CTD
PMID:16807353
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Rpl18
ribosomal protein L18
increases expression
ISO
Sorbitol results in increased expression of RPL18 mRNA
CTD
PMID:35678645
NCBI chr 1:96,188,811...96,191,452
Ensembl chr 1:96,188,112...96,191,452
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Snrnp200
small nuclear ribonucleoprotein U5 subunit 200
multiple interactions
ISO
Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein]
CTD
PMID:33939924
NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182
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Sord
sorbitol dehydrogenase
multiple interactions increases abundance increases metabolic processing
ISO
[SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose; epalrestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol]; ranirestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol]
CTD
PMID:32367058
NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
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Tardbp
TAR DNA binding protein
increases ubiquitination
ISO
Sorbitol results in increased ubiquitination of TARDBP protein
CTD
PMID:31780563
NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
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Tk1
thymidine kinase 1
increases expression
ISO
Sorbitol results in increased expression of TK1 mRNA
CTD
PMID:35678645
NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
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Ube2c
ubiquitin-conjugating enzyme E2C
decreases expression
ISO
Sorbitol results in decreased expression of UBE2C mRNA
CTD
PMID:35678645
NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
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Ubxn1
UBX domain protein 1
increases phosphorylation
ISO
Sorbitol results in increased phosphorylation of UBXN1 protein
CTD
PMID:15362974
NCBI chr 1:205,765,309...205,769,234
Ensembl chr 1:205,745,120...205,816,520
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
EXP
Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1 mRNA]; Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1A mRNA]
CTD
PMID:15327746
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Acacb
acetyl-CoA carboxylase beta
decreases expression
ISO
Mannitol results in decreased expression of ACACB mRNA
CTD
PMID:25270620
NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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Acly
ATP citrate lyase
increases expression
ISO
Mannitol results in increased expression of ACLY mRNA
CTD
PMID:25270620
NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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Adamts18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
increases expression
ISO
Mannitol results in increased expression of ADAMTS18 mRNA
CTD
PMID:25270620
NCBI chr19:41,686,951...41,840,035
Ensembl chr19:41,688,617...41,839,781
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Aida
axin interactor, dorsalization associated
decreases expression
ISO
Mannitol results in decreased expression of AIDA mRNA
CTD
PMID:25270620
NCBI chr13:94,940,311...94,967,920
Ensembl chr13:94,939,741...94,967,920
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Aire
autoimmune regulator
decreases expression
ISO
Mannitol results in decreased expression of AIRE mRNA
CTD
PMID:25270620
NCBI chr20:10,636,058...10,651,060
Ensembl chr20:10,636,123...10,651,060
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Aqp9
aquaporin 9
increases uptake
EXP
AQP9 protein results in increased uptake of Mannitol
CTD
PMID:9733774
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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Arhgap1
Rho GTPase activating protein 1
increases expression
ISO
Mannitol results in increased expression of ARHGAP1 mRNA
CTD
PMID:25270620
NCBI chr 3:77,621,377...77,643,400
Ensembl chr 3:77,620,655...77,643,396
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Arr3
arrestin 3
increases expression
ISO
Mannitol results in increased expression of ARR3 mRNA
CTD
PMID:25270620
NCBI chr X:65,699,881...65,712,224
Ensembl chr X:65,698,699...65,712,153
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Bad
BCL2-associated agonist of cell death
increases phosphorylation multiple interactions
EXP
Mannitol results in increased phosphorylation of BAD protein wortmannin inhibits the reaction [Mannitol results in increased phosphorylation of BAD protein]
CTD
PMID:15786717
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein]
CTD
PMID:29803612
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bbox1
gamma-butyrobetaine hydroxylase 1
decreases expression
ISO
Mannitol results in decreased expression of BBOX1 mRNA
CTD
PMID:25270620
NCBI chr 3:96,822,654...96,871,786
Ensembl chr 3:96,822,655...96,871,458
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Bcl2
BCL2, apoptosis regulator
increases expression
EXP
Mannitol results in increased expression of BCL2 protein
CTD
PMID:15786717
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Cables2
Cdk5 and Abl enzyme substrate 2
decreases expression
ISO
Mannitol results in decreased expression of CABLES2 mRNA
CTD
PMID:25270620
NCBI chr 3:167,347,527...167,362,274
Ensembl chr 3:167,347,461...167,362,279
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Casp3
caspase 3
multiple interactions increases activity
ISO
IGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein]; Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein]
CTD
PMID:10567913 PMID:12011046 PMID:29803612
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases activity
ISO
Mannitol results in increased activity of CASP9 protein
CTD
PMID:12011046
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cbx1
chromobox 1
increases expression
ISO
Mannitol results in increased expression of CBX1 mRNA
CTD
PMID:25270620
NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096
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Ccdc127
coiled-coil domain containing 127
decreases expression
ISO
Mannitol results in decreased expression of CCDC127 mRNA
CTD
PMID:25270620
NCBI chr 1:28,928,420...28,935,885
Ensembl chr 1:28,928,325...28,935,893
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Ccn3
cellular communication network factor 3
decreases expression
ISO
Mannitol results in decreased expression of CCN3 mRNA
CTD
PMID:25270620
NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019
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Ckap5
cytoskeleton associated protein 5
increases expression
ISO
Mannitol results in increased expression of CKAP5 mRNA
CTD
PMID:25270620
NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264
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Clcn3
chloride voltage-gated channel 3
affects response to substance
ISO
CLCN3 protein affects the susceptibility to Mannitol deficiency
CTD
PMID:22108225
NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119
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Ctnna2
catenin alpha 2
decreases expression
ISO
Mannitol results in decreased expression of CTNNA2 mRNA
CTD
PMID:25270620
NCBI chr 4:109,294,249...110,443,409
Ensembl chr 4:109,293,978...110,443,522
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Dbh
dopamine beta-hydroxylase
increases expression
ISO
Mannitol results in increased expression of DBH mRNA
CTD
PMID:25270620
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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Dctn2
dynactin subunit 2
increases expression
ISO
Mannitol results in increased expression of DCTN2 mRNA
CTD
PMID:25270620
NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543
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Dgka
diacylglycerol kinase, alpha
increases expression
ISO
Mannitol results in increased expression of DGKA mRNA
CTD
PMID:25270620
NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
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Elf2
E74 like ETS transcription factor 2
increases expression
ISO
Mannitol results in increased expression of ELF2 mRNA
CTD
PMID:25270620
NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947
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Fam185a
family with sequence similarity 185, member A
increases expression
ISO
Mannitol results in increased expression of FAM185A mRNA
CTD
PMID:25270620
NCBI chr 4:13,542,022...13,662,967
Ensembl chr 4:13,608,464...13,662,967
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Fam222a
family with sequence similarity 222, member A
decreases expression
ISO
Mannitol results in decreased expression of FAM222A mRNA
CTD
PMID:25270620
NCBI chr12:41,982,064...42,033,085
Ensembl chr12:41,986,780...42,033,682
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Fgf23
fibroblast growth factor 23
decreases export decreases expression multiple interactions
EXP ISO
Mannitol results in decreased export of FGF23 protein Mannitol results in decreased expression of FGF23 mRNA Mannitol inhibits the reaction [Sodium Chloride deficiency results in increased expression of FGF23 mRNA]; Mannitol inhibits the reaction [Sodium Chloride deficiency results in increased expression of FGF23 protein]
CTD
PMID:37992803
NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
Mannitol results in increased expression of FOS mRNA
CTD
PMID:11557636
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gal3st2
galactose-3-O-sulfotransferase 2
decreases expression
ISO
Mannitol results in decreased expression of GAL3ST2 mRNA
CTD
PMID:25270620
NCBI chr 9:94,382,456...94,387,990
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Gas2l2
growth arrest-specific 2 like 2
decreases expression
ISO
Mannitol results in decreased expression of GAS2L2 mRNA
CTD
PMID:25270620
NCBI chr10:68,222,475...68,229,877
Ensembl chr10:68,222,475...68,229,881
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Gpc6
glypican 6
increases expression
ISO
Mannitol results in increased expression of GPC6 mRNA
CTD
PMID:25270620
NCBI chr15:94,030,218...95,027,883
Ensembl chr15:94,029,884...95,024,006
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Gpr19
G protein-coupled receptor 19
decreases expression
ISO
Mannitol results in decreased expression of GPR19 mRNA
CTD
PMID:25270620
NCBI chr 4:167,710,944...167,739,232
Ensembl chr 4:167,710,666...167,741,036
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Hmox1
heme oxygenase 1
increases expression
ISO
Mannitol results in increased expression of HMOX1 mRNA
CTD
PMID:11592956
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hprt1
hypoxanthine phosphoribosyltransferase 1
increases expression
ISO
Mannitol results in increased expression of HPRT1 mRNA
CTD
PMID:25270620
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
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Hrh2
histamine receptor H 2
increases expression
ISO
Mannitol results in increased expression of HRH2 mRNA
CTD
PMID:25270620
NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
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Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 protein]
CTD
PMID:16285992
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Igf1
insulin-like growth factor 1
multiple interactions
ISO
IGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein]
CTD
PMID:10567913
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Il6
interleukin 6
multiple interactions
ISO
Mannitol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Rotenone inhibits the reaction [Mannitol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]
CTD
PMID:23867654
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
Mannitol results in increased expression of JUN mRNA
CTD
PMID:11557636
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Khdc3
KH domain containing 3, subcortical maternal complex member
increases expression
ISO
Mannitol results in increased expression of KHDC3 mRNA
CTD
PMID:25270620
NCBI chr 8:73,842,344...73,844,248
Ensembl chr 8:73,842,344...73,844,248
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Krtap11-1
keratin associated protein 11-1
increases expression
ISO
Mannitol results in increased expression of KRTAP11-1 mRNA
CTD
PMID:25270620
NCBI chr11:28,809,940...28,810,944
Ensembl chr11:28,810,341...28,810,892
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Lsm6
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
decreases expression
ISO
Mannitol results in decreased expression of LSM6 mRNA
CTD
PMID:25270620
NCBI chr19:29,098,254...29,112,858
Ensembl chr13:42,114,032...42,116,484 Ensembl chr19:42,114,032...42,116,484
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Map2k1
mitogen activated protein kinase kinase 1
multiple interactions
EXP
Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein]
CTD
PMID:16510265
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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Map2k2
mitogen activated protein kinase kinase 2
multiple interactions
EXP
Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]
CTD
PMID:16510265
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
Mannitol promotes the reaction [potassium chromate(VI) results in increased phosphorylation of MAPK1 protein]
CTD
PMID:10910949
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
Mannitol promotes the reaction [potassium chromate(VI) results in increased phosphorylation of MAPK8 protein]
CTD
PMID:10910949
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mta2
metastasis associated 1 family, member 2
increases expression
ISO
Mannitol results in increased expression of MTA2 mRNA
CTD
PMID:25270620
NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946
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Myl9
myosin light chain 9
decreases phosphorylation
EXP
Mannitol results in decreased phosphorylation of MYL9 protein
CTD
PMID:17272349
NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
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Mylk3
myosin light chain kinase 3
increases expression
ISO
Mannitol results in increased expression of MYLK3 mRNA
CTD
PMID:25270620
NCBI chr19:21,685,085...21,743,587
Ensembl chr19:21,691,929...21,742,954
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Naalad2
N-acetylated alpha-linked acidic dipeptidase 2
increases expression
ISO
Mannitol results in increased expression of NAALAD2 mRNA
CTD
PMID:25270620
NCBI chr 8:15,406,119...15,479,714
Ensembl chr 8:15,407,043...15,479,714
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Ndufa13
NADH:ubiquinone oxidoreductase subunit A13
decreases expression
ISO
Mannitol results in decreased expression of NDUFA13 mRNA
CTD
PMID:25270620
NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726
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Nfat5
nuclear factor of activated T-cells 5
increases expression multiple interactions
ISO EXP
Mannitol results in increased expression of NFAT5 mRNA Mannitol results in increased expression of NFAT5 mRNA; Mannitol results in increased expression of NFAT5 protein Mannitol inhibits the reaction [Sodium Chloride deficiency results in decreased expression of NFAT5 mRNA]
CTD
PMID:23867654 PMID:37992803
NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
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Nkg7
natural killer cell granule protein 7
increases expression
ISO
Mannitol results in increased expression of NKG7 mRNA
CTD
PMID:25270620
NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983
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Nppa
natriuretic peptide A
increases expression
ISO
Mannitol results in increased expression of NPPA protein
CTD
PMID:2177369
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Nts
neurotensin
increases transport
EXP
NTS protein results in increased transport of Mannitol
CTD
PMID:11208724
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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Oat
ornithine aminotransferase
multiple interactions
EXP
Mannitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein]
CTD
PMID:2827574
NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
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Pcp2
Purkinje cell protein 2
increases expression
ISO
Mannitol results in increased expression of PCP2 mRNA
CTD
PMID:25270620
NCBI chr12:1,681,659...1,683,899
Ensembl chr12:1,681,659...1,683,899
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Pdcd4
programmed cell death 4
increases expression decreases expression
ISO
Mannitol results in increased expression of PDCD4 mRNA Mannitol results in decreased expression of PDCD4 mRNA
CTD
PMID:21873647
NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
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Phex
phosphate regulating endopeptidase X-linked
increases expression
EXP
Mannitol results in increased expression of PHEX mRNA
CTD
PMID:37992803
NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469
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Plcl2
phospholipase C-like 2
decreases expression
ISO
Mannitol results in decreased expression of PLCL2 mRNA
CTD
PMID:25270620
NCBI chr 9:3,292,564...3,477,009
Ensembl chr 9:3,292,695...3,477,009
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Plekho1
pleckstrin homology domain containing O1
increases expression
ISO
Mannitol results in increased expression of PLEKHO1 mRNA
CTD
PMID:25270620
NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785
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Pou1f1
POU class 1 homeobox 1
increases expression
ISO
Mannitol results in increased expression of POU1F1 mRNA
CTD
PMID:25270620
NCBI chr11:3,316,818...3,334,804
Ensembl chr11:3,317,058...3,334,801
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Ppp1r10
protein phosphatase 1, regulatory subunit 10
decreases expression
ISO
Mannitol results in decreased expression of PPP1R10 mRNA
CTD
PMID:25270620
NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611
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Ppp4c
protein phosphatase 4, catalytic subunit
increases expression
ISO
Mannitol results in increased expression of PPP4C mRNA
CTD
PMID:25270620
NCBI chr 1:181,392,899...181,399,703
Ensembl chr 1:181,392,923...181,399,659
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Prkcb
protein kinase C, beta
multiple interactions
ISO
Mannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]; Mannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein]
CTD
PMID:16285992
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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Prkcd
protein kinase C, delta
multiple interactions
ISO
Mannitol inhibits the reaction [Glucose results in increased expression of PRKCD protein]
CTD
PMID:16285992
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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Ptger1
prostaglandin E receptor 1
increases expression
EXP
Mannitol results in increased expression of PTGER1 mRNA
CTD
PMID:12888618
NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559
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Ptger4
prostaglandin E receptor 4
decreases expression
EXP
Mannitol results in decreased expression of PTGER4 mRNA
CTD
PMID:12888618
NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
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Ptk2
protein tyrosine kinase 2
multiple interactions
ISO
benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Mannitol results in decreased phosphorylation of and results in increased degradation of PTK2 protein]; Mannitol results in decreased phosphorylation of and results in increased degradation of PTK2 protein
CTD
PMID:12011046
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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Ralgdsl3
ral guanine nucleotide dissociation stimulator like 3
increases expression
ISO
Mannitol results in increased expression of RGL3 mRNA
CTD
PMID:25270620
NCBI chr 8:20,500,846...20,520,471
Ensembl chr 8:20,500,846...20,520,471
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Rbl1
RB transcriptional corepressor like 1
decreases expression
ISO
Mannitol results in decreased expression of RBL1 mRNA
CTD
PMID:25270620
NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
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Rbp2
retinol binding protein 2
decreases expression
ISO
Mannitol results in decreased expression of RBP2 mRNA
CTD
PMID:25270620
NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473
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Samd10
sterile alpha motif domain containing 10
decreases expression
ISO
Mannitol results in decreased expression of SAMD10 mRNA
CTD
PMID:25270620
NCBI chr 3:168,700,280...168,704,427
Ensembl chr 3:168,700,284...168,705,248
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Sbsn
suprabasin
decreases expression
ISO
Mannitol results in decreased expression of SBSN mRNA
CTD
PMID:25270620
NCBI chr 1:85,978,970...86,006,034
Ensembl chr 1:86,001,567...86,006,034
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Sele
selectin E
multiple interactions
ISO
Mannitol inhibits the reaction [Glucose results in increased expression of SELE mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of SELE protein]
CTD
PMID:16285992
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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Sgsm3
small G protein signaling modulator 3
decreases expression
ISO
Mannitol results in decreased expression of SGSM3 mRNA
CTD
PMID:25270620
NCBI chr 7:112,514,453...112,544,109
Ensembl chr 7:112,514,630...112,544,108
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Slc12a1
solute carrier family 12 member 1
increases activity multiple interactions
EXP
Mannitol results in increased activity of SLC12A1 protein [Mannitol results in increased activity of SLC12A1 protein] which results in increased import of Water
CTD
PMID:12433675
NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899
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Slc2a8
solute carrier family 2 member 8
decreases expression
ISO
Mannitol results in decreased expression of SLC2A8 mRNA
CTD
PMID:25270620
NCBI chr 3:16,274,918...16,284,536
Ensembl chr 3:16,274,925...16,284,464
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
multiple interactions
EXP
Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of SRC protein]
CTD
PMID:16510265
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Stx8
syntaxin 8
decreases expression
ISO
Mannitol results in decreased expression of STX8 mRNA
CTD
PMID:25270620
NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993
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Timd4
T-cell immunoglobulin and mucin domain containing 4
decreases expression
ISO
Mannitol results in decreased expression of TIMD4 mRNA
CTD
PMID:25270620
NCBI chr10:31,185,751...31,221,843
Ensembl chr10:31,185,731...31,220,966
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Tnf
tumor necrosis factor
multiple interactions
ISO
Mannitol inhibits the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]; Mannitol inhibits the reaction [Quartz results in increased secretion of TNF protein]
CTD
PMID:19298665
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip3
TNF alpha induced protein 3
increases expression
ISO
Mannitol results in increased expression of TNFAIP3 mRNA
CTD
PMID:21873647
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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Tp53
tumor protein p53
multiple interactions
ISO
Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein]
CTD
PMID:29803612
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tpd52
tumor protein D52
decreases expression increases expression
ISO
Mannitol results in decreased expression of TPD52 mRNA Mannitol results in increased expression of TPD52 mRNA
CTD
PMID:21873647
NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622
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Triml1
tripartite motif family-like 1
increases expression
ISO
Mannitol results in increased expression of TRIML1 mRNA
CTD
PMID:25270620
NCBI chr16:48,994,968...49,005,343
Ensembl chr16:48,997,252...49,005,417
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Ulbp1
UL16 binding protein 1
increases expression
ISO
Mannitol results in increased expression of ULBP1 mRNA
CTD
PMID:25270620
NCBI chr 1:1,694,255...1,716,160
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Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
Mannitol inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of VCAM1 protein]
CTD
PMID:16285992
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Wdr20
WD repeat domain 20
decreases expression
ISO
Mannitol results in decreased expression of WDR20 mRNA
CTD
PMID:25270620
NCBI chr 6:129,751,952...129,821,464
Ensembl chr 6:129,752,014...129,847,339
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Zfp13
zinc finger protein 13
decreases expression
ISO
Mannitol results in decreased expression of ZFP13 mRNA
CTD
PMID:25270620
NCBI chr10:12,615,455...12,623,615
Ensembl chr10:12,615,190...12,623,615
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Zg16
zymogen granule protein 16
decreases expression
ISO
Mannitol results in decreased expression of ZG16 mRNA
CTD
PMID:25270620
NCBI chr 1:181,657,722...181,660,079
Ensembl chr 1:181,657,722...181,660,079
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
[Biofuels co-treated with Triacetin] results in decreased expression of BCL2 mRNA
CTD
PMID:30738890
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions
ISO
[Biofuels co-treated with Triacetin] results in decreased expression of CASP3 mRNA
CTD
PMID:30738890
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
[Biofuels co-treated with Triacetin] affects the expression of CYP1A1 mRNA
CTD
PMID:30738890
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Triacetin results in increased expression of DDIT3 mRNA
CTD
PMID:21703327
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Hmox1
heme oxygenase 1
multiple interactions
ISO
[Biofuels co-treated with Triacetin] affects the expression of HMOX1 mRNA
CTD
PMID:30738890
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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