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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:food anticaking agent
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Accession:CHEBI:77965 term browser browse the term
Definition:An anticaking agent that is used to reduced the tendency of particles of food to adhere to one another.
Synonyms:related_synonym: food anti-caking agent;   food anti-caking agents


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calcium silicate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing increases expression ISO calcium silicate results in increased expression of ADIPOQ mRNA CTD PMID:29279043 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G ALB albumin increases expression ISO calcium silicate results in increased expression of ALB mRNA CTD PMID:29279043 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G ALPL alkaline phosphatase, biomineralization associated multiple interactions ISO [Zinc binds to calcium silicate] which results in increased expression of ALPL mRNA CTD PMID:23483914 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410 		JBrowse link
G AMBP alpha-1-microglobulin/bikunin precursor increases expression ISO calcium silicate results in increased expression of AMBP mRNA CTD PMID:29279043 NCBI chr 9:114,060,127...114,078,300
Ensembl chr 9:114,060,127...114,078,328 		JBrowse link
G ANKRD39 ankyrin repeat domain 39 increases expression ISO calcium silicate results in increased expression of ANKRD39 mRNA CTD PMID:29279043 NCBI chr 2:96,847,990...96,858,016
Ensembl chr 2:96,836,611...96,858,016 		JBrowse link
G AOAH acyloxyacyl hydrolase increases expression ISO calcium silicate results in increased expression of AOAH mRNA CTD PMID:29279043 NCBI chr 7:36,512,941...36,724,494
Ensembl chr 7:36,509,308...36,724,549 		JBrowse link
G APOA2 apolipoprotein A2 increases expression ISO calcium silicate results in increased expression of APOA2 mRNA CTD PMID:29279043 NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,290...161,223,631 		JBrowse link
G APOB apolipoprotein B increases expression ISO calcium silicate results in increased expression of APOB mRNA CTD PMID:29279043 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073 		JBrowse link
G ARMCX2 armadillo repeat containing X-linked 2 decreases expression ISO calcium silicate results in decreased expression of ARMCX2 mRNA CTD PMID:29279043 NCBI chr  X:101,655,281...101,659,850
Ensembl chr  X:101,655,281...101,659,850 		JBrowse link
G ASTE1 asteroid homolog 1 increases expression ISO calcium silicate results in increased expression of ASTE1 mRNA CTD PMID:29279043 NCBI chr 3:131,013,875...131,026,825
Ensembl chr 3:131,013,875...131,027,649 		JBrowse link
G BCL9L BCL9 like decreases expression ISO calcium silicate results in decreased expression of BCL9L mRNA CTD PMID:29279043 NCBI chr11:118,896,136...118,925,926
Ensembl chr11:118,893,875...118,925,926 		JBrowse link
G BGN biglycan decreases expression ISO calcium silicate results in decreased expression of BGN mRNA CTD PMID:29279043 NCBI chr  X:153,494,980...153,509,546
Ensembl chr  X:153,494,980...153,509,546 		JBrowse link
G BMAL1 basic helix-loop-helix ARNT like 1 increases expression ISO calcium silicate results in increased expression of BMAL1 mRNA CTD PMID:29279043 NCBI chr11:13,276,652...13,387,266
Ensembl chr11:13,276,652...13,387,266 		JBrowse link
G BPTF bromodomain PHD finger transcription factor decreases expression ISO calcium silicate results in decreased expression of BPTF mRNA CTD PMID:29279043 NCBI chr17:67,825,503...67,984,378
Ensembl chr17:67,825,503...67,984,378 		JBrowse link
G CA3 carbonic anhydrase 3 increases expression ISO calcium silicate results in increased expression of CAR3 mRNA CTD PMID:29279043 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040 		JBrowse link
G CAPNS1 calpain small subunit 1 decreases expression ISO calcium silicate results in decreased expression of CAPNS1 mRNA CTD PMID:29279043 NCBI chr19:36,140,066...36,150,353
Ensembl chr19:36,139,953...36,150,353 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression ISO calcium silicate results in increased expression of CCL2 protein CTD PMID:16601788 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 increases expression ISO calcium silicate results in increased expression of CCL3 protein CTD PMID:16601788 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CHRNB3 cholinergic receptor nicotinic beta 3 subunit increases expression ISO calcium silicate results in increased expression of CHRNB3 mRNA CTD PMID:29279043 NCBI chr 8:42,697,366...42,737,407
Ensembl chr 8:42,697,366...42,737,407 		JBrowse link
G CLCA1 chloride channel accessory 1 increases expression ISO calcium silicate results in increased expression of CLCA1 mRNA CTD PMID:29279043 NCBI chr 1:86,468,927...86,500,259
Ensembl chr 1:86,468,368...86,500,259 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO [Zinc binds to calcium silicate] which results in increased expression of COL1A1 mRNA CTD PMID:23483914 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion
multiple interactions		 EXP calcium silicate results in increased secretion of CXCL8 protein
RTKI cpd inhibits the reaction [calcium silicate results in increased secretion of CXCL8 protein]		 CTD PMID:21762757 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYBB cytochrome b-245 beta chain increases expression ISO calcium silicate results in increased expression of CYBB mRNA CTD PMID:29279043 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461 		JBrowse link
G DDO D-aspartate oxidase decreases expression ISO calcium silicate results in decreased expression of DDO mRNA CTD PMID:29279043 NCBI chr 6:110,388,321...110,415,575
Ensembl chr 6:110,391,771...110,415,575 		JBrowse link
G DHX35 DEAH-box helicase 35 increases expression ISO calcium silicate results in increased expression of DHX35 mRNA CTD PMID:29279043 NCBI chr20:38,962,344...39,039,721
Ensembl chr20:38,962,299...39,039,723 		JBrowse link
G DPP10 dipeptidyl peptidase like 10 increases expression ISO calcium silicate results in increased expression of DPP10 mRNA CTD PMID:29279043 NCBI chr 2:114,442,641...115,845,780
Ensembl chr 2:114,442,299...115,845,780 		JBrowse link
G EGFR epidermal growth factor receptor increases activity EXP calcium silicate results in increased activity of EGFR protein CTD PMID:21762757 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G EPB42 erythrocyte membrane protein band 4.2 increases expression ISO calcium silicate results in increased expression of EPB42 mRNA CTD PMID:29279043 NCBI chr15:43,197,227...43,225,737
Ensembl chr15:43,197,227...43,221,018 		JBrowse link
G FAM83H family with sequence similarity 83 member H increases expression ISO calcium silicate results in increased expression of FAM83H mRNA CTD PMID:29279043 NCBI chr 8:143,723,933...143,733,779
Ensembl chr 8:143,723,933...143,738,234 		JBrowse link
G FGG fibrinogen gamma chain increases expression ISO calcium silicate results in increased expression of FGG mRNA CTD PMID:29279043 NCBI chr 4:154,604,136...154,612,656
Ensembl chr 4:154,604,134...154,612,967 		JBrowse link
G FGL1 fibrinogen like 1 increases expression ISO calcium silicate results in increased expression of FGL1 mRNA CTD PMID:29279043 NCBI chr 8:17,864,389...17,895,538
Ensembl chr 8:17,864,380...17,910,365 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 increases secretion
multiple interactions		 EXP calcium silicate results in increased secretion of FLT1 protein
RTKI cpd inhibits the reaction [calcium silicate results in increased secretion of FLT1 protein]		 CTD PMID:21762757 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145 		JBrowse link
G GC GC vitamin D binding protein increases expression ISO calcium silicate results in increased expression of GC mRNA CTD PMID:29279043 NCBI chr 4:71,741,693...71,805,520
Ensembl chr 4:71,741,696...71,804,041 		JBrowse link
G GLT8D1 glycosyltransferase 8 domain containing 1 increases expression ISO calcium silicate results in increased expression of GLT8D1 mRNA CTD PMID:29279043 NCBI chr 3:52,694,486...52,705,791
Ensembl chr 3:52,694,486...52,706,032 		JBrowse link
G GSR glutathione-disulfide reductase increases activity ISO calcium silicate results in increased activity of GSR protein CTD PMID:16601788 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G H1-2 H1.2 linker histone, cluster member decreases expression ISO calcium silicate results in decreased expression of H1F2 mRNA CTD PMID:29279043 NCBI chr 6:26,055,740...26,056,470
Ensembl chr 6:26,054,760...26,056,470 		JBrowse link
G H3C12 H3 clustered histone 12 increases expression ISO calcium silicate results in increased expression of H3C8 mRNA CTD PMID:29279043 NCBI chr 6:27,890,315...27,890,826
Ensembl chr 6:27,890,315...27,893,106 		JBrowse link
G HLF HLF transcription factor, PAR bZIP family member decreases expression ISO calcium silicate results in decreased expression of HLF mRNA CTD PMID:29279043 NCBI chr17:55,264,960...55,325,187
Ensembl chr17:55,264,960...55,325,187 		JBrowse link
G HMG20B high mobility group 20B decreases expression ISO calcium silicate results in decreased expression of HMG20B mRNA CTD PMID:29279043 NCBI chr19:3,572,944...3,579,083
Ensembl chr19:3,572,777...3,579,088 		JBrowse link
G HPCAL1 hippocalcin like 1 increases expression ISO calcium silicate results in increased expression of HPCAL1 mRNA CTD PMID:29279043 NCBI chr 2:10,302,904...10,427,604
Ensembl chr 2:10,302,889...10,427,617 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions ISO [Zinc binds to calcium silicate] which results in increased expression of IGF1 mRNA CTD PMID:23483914 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker) increases expression ISO calcium silicate results in increased expression of IGHG3 mRNA CTD PMID:29279043 NCBI chr14:105,765,914...105,771,405
Ensembl chr14:105,764,503...105,771,405 		JBrowse link
G IGHM immunoglobulin heavy constant mu increases expression ISO calcium silicate results in increased expression of IGHM mRNA CTD PMID:29279043 NCBI chr14:105,851,966...105,856,217
Ensembl chr14:105,851,705...105,856,218 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases secretion		 EXP Acetylcysteine inhibits the reaction [calcium silicate results in increased secretion of IL6 protein]; prolinedithiocarbamate inhibits the reaction [calcium silicate results in increased secretion of IL6 protein] CTD PMID:21762757 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IPMK inositol polyphosphate multikinase decreases expression ISO calcium silicate results in decreased expression of IPMK mRNA CTD PMID:29279043 NCBI chr10:58,191,517...58,267,894
Ensembl chr10:58,191,517...58,267,894 		JBrowse link
G KANK4 KN motif and ankyrin repeat domains 4 decreases expression ISO calcium silicate results in decreased expression of KANK4 mRNA CTD PMID:29279043 NCBI chr 1:62,236,165...62,319,434
Ensembl chr 1:62,236,165...62,319,434 		JBrowse link
G KAT8 lysine acetyltransferase 8 increases expression ISO calcium silicate results in increased expression of KAT8 mRNA CTD PMID:29279043 NCBI chr16:31,117,664...31,131,393
Ensembl chr16:31,114,489...31,131,393 		JBrowse link
G KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 decreases expression ISO calcium silicate results in decreased expression of KCNMB4 mRNA CTD PMID:29279043 NCBI chr12:70,366,290...70,434,292
Ensembl chr12:70,366,290...70,434,292 		JBrowse link
G KDR kinase insert domain receptor increases secretion EXP calcium silicate results in increased secretion of KDR protein CTD PMID:21762757 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G KLHL2 kelch like family member 2 decreases expression ISO calcium silicate results in decreased expression of KLHL2 mRNA CTD PMID:29279043 NCBI chr 4:165,207,561...165,323,156
Ensembl chr 4:165,207,561...165,323,156 		JBrowse link
G LDB1 LIM domain binding 1 decreases expression ISO calcium silicate results in decreased expression of LDB1 mRNA CTD PMID:29279043 NCBI chr10:102,102,088...102,121,442
Ensembl chr10:102,106,489...102,120,368 		JBrowse link
G LINC01159 long intergenic non-protein coding RNA 1159 increases expression ISO calcium silicate results in increased expression of PANTR2 mRNA CTD PMID:29279043 NCBI chr 2:104,865,497...104,872,595
Ensembl chr 2:104,865,401...104,874,447 		JBrowse link
G LMO7 LIM domain 7 decreases expression ISO calcium silicate results in decreased expression of LMO7 mRNA CTD PMID:29279043 NCBI chr13:75,620,434...75,859,870
Ensembl chr13:75,620,434...75,859,870 		JBrowse link
G LTN1 listerin E3 ubiquitin protein ligase 1 decreases expression ISO calcium silicate results in decreased expression of LTN1 mRNA CTD PMID:29279043 NCBI chr21:28,928,144...28,992,877
Ensembl chr21:28,928,144...28,992,956 		JBrowse link
G MALT1 MALT1 paracaspase increases expression ISO calcium silicate results in increased expression of MALT1 mRNA CTD PMID:29279043 NCBI chr18:58,671,465...58,754,477
Ensembl chr18:58,671,465...58,754,477 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP RTKI cpd inhibits the reaction [calcium silicate results in increased phosphorylation of MAPK1 protein] CTD PMID:21762757 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP calcium silicate results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [calcium silicate results in increased phosphorylation of MAPK3 protein]		 CTD PMID:21762757 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MATK megakaryocyte-associated tyrosine kinase increases expression ISO calcium silicate results in increased expression of MATK mRNA CTD PMID:29279043 NCBI chr19:3,777,973...3,801,799
Ensembl chr19:3,777,970...3,802,129 		JBrowse link
G METTL8 methyltransferase 8, tRNA N3-cytidine increases expression ISO calcium silicate results in increased expression of METTL8 mRNA CTD PMID:29279043 NCBI chr 2:171,315,746...171,434,772
Ensembl chr 2:171,315,746...171,434,802 		JBrowse link
G MFSD11 major facilitator superfamily domain containing 11 decreases expression ISO calcium silicate results in decreased expression of MFSD11 mRNA CTD PMID:29279043 NCBI chr17:76,736,634...76,803,805
Ensembl chr17:76,735,865...76,781,449 		JBrowse link
G NAA38 N-alpha-acetyltransferase 38, NatC auxiliary subunit increases expression ISO calcium silicate results in increased expression of NAA38 mRNA CTD PMID:29279043 NCBI chr17:7,856,685...7,885,420
Ensembl chr17:7,856,685...7,885,238 		JBrowse link
G NANP N-acetylneuraminic acid phosphatase decreases expression ISO calcium silicate results in decreased expression of NANP mRNA CTD PMID:29279043 NCBI chr20:25,612,935...25,624,014
Ensembl chr20:25,612,935...25,624,014 		JBrowse link
G NOP53 NOP53 ribosome biogenesis factor increases expression ISO calcium silicate results in increased expression of NOP53 mRNA CTD PMID:29279043 NCBI chr19:47,745,546...47,757,058
Ensembl chr19:47,745,546...47,757,058 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 decreases expression ISO calcium silicate results in decreased expression of NR1D1 mRNA CTD PMID:29279043 NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589 		JBrowse link
G NR1D2 nuclear receptor subfamily 1 group D member 2 decreases expression ISO calcium silicate results in decreased expression of NR1D2 mRNA CTD PMID:29279043 NCBI chr 3:23,945,286...23,980,617
Ensembl chr 3:23,945,286...23,980,637 		JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 increases expression ISO calcium silicate results in increased expression of NTRK3 mRNA CTD PMID:29279043 NCBI chr15:87,859,751...88,256,739
Ensembl chr15:87,859,751...88,256,791 		JBrowse link
G OAF out at first homolog increases expression ISO calcium silicate results in increased expression of OAF mRNA CTD PMID:29279043 NCBI chr11:120,211,032...120,230,334
Ensembl chr11:120,211,032...120,230,334 		JBrowse link
G ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 increases expression ISO calcium silicate results in increased expression of ORMDL2 mRNA CTD PMID:29279043 NCBI chr12:55,818,041...55,821,879
Ensembl chr12:55,818,041...55,821,879 		JBrowse link
G OSBPL3 oxysterol binding protein like 3 increases expression ISO calcium silicate results in increased expression of OSBPL3 mRNA CTD PMID:29279043 NCBI chr 7:24,796,537...24,981,845
Ensembl chr 7:24,796,540...24,981,634 		JBrowse link
G P4HA2 prolyl 4-hydroxylase subunit alpha 2 decreases expression ISO calcium silicate results in decreased expression of P4HA2 mRNA CTD PMID:29279043 NCBI chr 5:132,190,147...132,227,853
Ensembl chr 5:132,190,147...132,295,315 		JBrowse link
G PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 decreases expression ISO calcium silicate results in decreased expression of PAG1 mRNA CTD PMID:29279043 NCBI chr 8:80,967,810...81,112,068
Ensembl chr 8:80,967,810...81,112,068 		JBrowse link
G PER3 period circadian regulator 3 decreases expression ISO calcium silicate results in decreased expression of PER3 mRNA CTD PMID:29279043 NCBI chr 1:7,784,291...7,845,177
Ensembl chr 1:7,784,291...7,845,177 		JBrowse link
G PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 decreases expression ISO calcium silicate results in decreased expression of PFKFB3 mRNA CTD PMID:29279043 NCBI chr10:6,144,921...6,326,637
Ensembl chr10:6,144,934...6,254,644 		JBrowse link
G PHGDH phosphoglycerate dehydrogenase increases expression ISO calcium silicate results in increased expression of PHGDH mRNA CTD PMID:29279043 NCBI chr 1:119,711,934...119,744,215
Ensembl chr 1:119,648,411...119,744,218 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma increases expression ISO calcium silicate results in increased expression of PIK3CG mRNA CTD PMID:29279043 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980 		JBrowse link
G PLAA phospholipase A2 activating protein increases expression ISO calcium silicate results in increased expression of PLAA mRNA CTD PMID:29279043 NCBI chr 9:26,903,372...26,947,242
Ensembl chr 9:26,903,372...26,947,242 		JBrowse link
G PMM2 phosphomannomutase 2 increases expression ISO calcium silicate results in increased expression of PMM2 mRNA CTD PMID:29279043 NCBI chr16:8,797,839...8,849,325
Ensembl chr16:8,788,823...8,862,534 		JBrowse link
G PRPF19 pre-mRNA processing factor 19 decreases expression ISO calcium silicate results in decreased expression of PRPF19 mRNA CTD PMID:29279043 NCBI chr11:60,890,547...60,906,585
Ensembl chr11:60,890,547...60,906,585 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases localization EXP calcium silicate results in increased localization of RELA protein CTD PMID:21762757 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RHOBTB2 Rho related BTB domain containing 2 increases expression ISO calcium silicate results in increased expression of RHOBTB2 mRNA CTD PMID:29279043 NCBI chr 8:22,950,813...23,020,199
Ensembl chr 8:22,987,417...23,020,509 		JBrowse link
G RNMT RNA guanine-7 methyltransferase decreases expression ISO calcium silicate results in decreased expression of RNMT mRNA CTD PMID:29279043 NCBI chr18:13,726,673...13,764,556
Ensembl chr18:13,726,660...13,764,556 		JBrowse link
G RPS25 ribosomal protein S25 decreases expression ISO calcium silicate results in decreased expression of RPS25 mRNA CTD PMID:29279043 NCBI chr11:119,015,717...119,018,343
Ensembl chr11:119,015,712...119,018,691 		JBrowse link
G RWDD3 RWD domain containing 3 increases expression ISO calcium silicate results in increased expression of RWDD3 mRNA CTD PMID:29279043 NCBI chr 1:95,234,155...95,247,225
Ensembl chr 1:95,234,210...95,247,225 		JBrowse link
G SCGB3A1 secretoglobin family 3A member 1 increases expression ISO calcium silicate results in increased expression of SCGB3A1 mRNA CTD PMID:29279043 NCBI chr 5:180,590,105...180,591,499
Ensembl chr 5:180,590,105...180,591,499 		JBrowse link
G SCHIP1 schwannomin interacting protein 1 decreases expression ISO calcium silicate results in decreased expression of SCHIP1 mRNA CTD PMID:29279043 NCBI chr 3:159,273,244...159,897,359
Ensembl chr 3:159,273,244...159,897,629 		JBrowse link
G SGMS1 sphingomyelin synthase 1 decreases expression ISO calcium silicate results in decreased expression of SGMS1 mRNA CTD PMID:29279043 NCBI chr10:50,305,600...50,625,184
Ensembl chr10:50,305,586...50,625,163 		JBrowse link
G SLC1A5 solute carrier family 1 member 5 decreases expression ISO calcium silicate results in decreased expression of SLC1A5 mRNA CTD PMID:29279043 NCBI chr19:46,774,883...46,788,594
Ensembl chr19:46,774,883...46,788,594 		JBrowse link
G SLC38A10 solute carrier family 38 member 10 decreases expression ISO calcium silicate results in decreased expression of SLC38A10 mRNA CTD PMID:29279043 NCBI chr17:81,244,811...81,295,307
Ensembl chr17:81,244,811...81,295,547 		JBrowse link
G SLC6A13 solute carrier family 6 member 13 increases expression ISO calcium silicate results in increased expression of SLC6A13 mRNA CTD PMID:29279043 NCBI chr12:220,622...262,836
Ensembl chr12:220,621...262,873 		JBrowse link
G SNORD61 small nucleolar RNA, C/D box 61 decreases expression ISO calcium silicate results in decreased expression of SNORD61 mRNA CTD PMID:29279043 NCBI chr  X:136,879,199...136,879,271
Ensembl chr  X:136,879,199...136,879,271 		JBrowse link
G SOD1 superoxide dismutase 1 decreases activity ISO calcium silicate results in decreased activity of SOD1 protein CTD PMID:16601788 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SSBP3 single stranded DNA binding protein 3 decreases expression ISO calcium silicate results in decreased expression of SSBP3 mRNA CTD PMID:29279043 NCBI chr 1:54,225,432...54,413,490
Ensembl chr 1:54,225,432...54,413,479 		JBrowse link
G TAF10 TATA-box binding protein associated factor 10 increases expression ISO calcium silicate results in increased expression of TAF10 mRNA CTD PMID:29279043 NCBI chr11:6,606,294...6,612,216
Ensembl chr11:6,606,294...6,612,539 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO [Zinc binds to calcium silicate] which results in increased expression of TGFB1 mRNA CTD PMID:23483914 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G THEM7P thioesterase superfamily member 7, pseudogene increases expression ISO calcium silicate results in increased expression of THEM7 mRNA CTD PMID:29279043 NCBI chr11:32,112,049...32,168,823
Ensembl chr11:32,112,049...32,254,395 		JBrowse link
G TMEM171 transmembrane protein 171 increases expression ISO calcium silicate results in increased expression of TMEM171 mRNA CTD PMID:29279043 NCBI chr 5:73,120,575...73,131,809
Ensembl chr 5:73,120,569...73,131,809 		JBrowse link
G TMEM54 transmembrane protein 54 increases expression ISO calcium silicate results in increased expression of TMEM54 mRNA CTD PMID:29279043 NCBI chr 1:32,894,595...32,901,389
Ensembl chr 1:32,894,594...32,901,438 		JBrowse link
G TMOD4 tropomodulin 4 increases expression ISO calcium silicate results in increased expression of TMOD4 mRNA CTD PMID:29279043 NCBI chr 1:151,169,987...151,175,981
Ensembl chr 1:151,169,986...151,176,284 		JBrowse link
G TP53 tumor protein p53 increases expression ISO calcium silicate results in increased expression of TRP53 mRNA CTD PMID:29279043 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TUBA1C tubulin alpha 1c decreases expression ISO calcium silicate results in decreased expression of TUBA1C mRNA CTD PMID:29279043 NCBI chr12:49,227,926...49,274,600
Ensembl chr12:49,188,736...49,274,600 		JBrowse link
G VEGFA vascular endothelial growth factor A increases secretion
multiple interactions		 EXP calcium silicate results in increased secretion of VEGFA protein
RTKI cpd inhibits the reaction [calcium silicate results in increased secretion of VEGFA protein]		 CTD PMID:21762757 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VPS35L VPS35 endosomal protein sorting factor like increases expression ISO calcium silicate results in increased expression of VPS35L mRNA CTD PMID:29279043 NCBI chr16:19,555,703...19,701,163
Ensembl chr16:19,555,240...19,706,793 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A decreases expression ISO calcium silicate results in decreased expression of ZC3H12A mRNA CTD PMID:29279043 NCBI chr 1:37,474,580...37,484,377
Ensembl chr 1:37,474,580...37,484,377 		JBrowse link
G ZMYND8 zinc finger MYND-type containing 8 increases expression ISO calcium silicate results in increased expression of ZMYND8 mRNA CTD PMID:29279043 NCBI chr20:47,209,214...47,356,699
Ensembl chr20:47,209,214...47,356,889 		JBrowse link
D-mannitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions ISO Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1 mRNA]; Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1A mRNA] CTD PMID:15327746 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ACACB acetyl-CoA carboxylase beta decreases expression ISO Mannitol results in decreased expression of ACACB mRNA CTD PMID:25270620 NCBI chr12:109,111,189...109,268,226
Ensembl chr12:109,116,587...109,268,226 		JBrowse link
G ACLY ATP citrate lyase increases expression ISO Mannitol results in increased expression of ACLY mRNA CTD PMID:25270620 NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542 		JBrowse link
G ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif 18 increases expression ISO Mannitol results in increased expression of ADAMTS18 mRNA CTD PMID:25270620 NCBI chr16:77,282,128...77,435,034
Ensembl chr16:77,247,813...77,435,034 		JBrowse link
G AIDA axin interactor, dorsalization associated decreases expression ISO Mannitol results in decreased expression of AIDA mRNA CTD PMID:25270620 NCBI chr 1:222,668,013...222,712,491
Ensembl chr 1:222,668,013...222,713,210 		JBrowse link
G AIRE autoimmune regulator decreases expression ISO Mannitol results in decreased expression of AIRE mRNA CTD PMID:25270620 NCBI chr21:44,285,876...44,298,648
Ensembl chr21:44,285,838...44,298,648 		JBrowse link
G AQP9 aquaporin 9 increases uptake ISO AQP9 protein results in increased uptake of Mannitol CTD PMID:9733774 NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911 		JBrowse link
G ARHGAP1 Rho GTPase activating protein 1 increases expression ISO Mannitol results in increased expression of ARHGAP1 mRNA CTD PMID:25270620 NCBI chr11:46,677,080...46,700,619
Ensembl chr11:46,677,080...46,700,619 		JBrowse link
G ARR3 arrestin 3 increases expression ISO Mannitol results in increased expression of ARR3 mRNA CTD PMID:25270620 NCBI chr  X:70,268,334...70,281,883
Ensembl chr  X:70,268,305...70,281,840 		JBrowse link
G BAD BCL2 associated agonist of cell death increases phosphorylation
multiple interactions		 ISO Mannitol results in increased phosphorylation of BAD protein
wortmannin inhibits the reaction [Mannitol results in increased phosphorylation of BAD protein]		 CTD PMID:15786717 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein] CTD PMID:29803612 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BBOX1 gamma-butyrobetaine hydroxylase 1 decreases expression ISO Mannitol results in decreased expression of BBOX1 mRNA CTD PMID:25270620 NCBI chr11:27,040,815...27,127,809
Ensembl chr11:27,040,725...27,127,809 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression ISO Mannitol results in increased expression of BCL2 protein CTD PMID:15786717 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CABLES2 Cdk5 and Abl enzyme substrate 2 decreases expression ISO Mannitol results in decreased expression of CABLES2 mRNA CTD PMID:25270620 NCBI chr20:62,388,634...62,407,285
Ensembl chr20:62,388,634...62,407,285 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 EXP IGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein]; Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein] CTD PMID:10567913 PMID:12011046 PMID:29803612 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 increases activity EXP Mannitol results in increased activity of CASP9 protein CTD PMID:12011046 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CBX1 chromobox 1 increases expression ISO Mannitol results in increased expression of CBX1 mRNA CTD PMID:25270620 NCBI chr17:48,070,059...48,101,478
Ensembl chr17:48,070,052...48,101,478 		JBrowse link
G CCDC127 coiled-coil domain containing 127 decreases expression ISO Mannitol results in decreased expression of CCDC127 mRNA CTD PMID:25270620 NCBI chr 5:196,868...218,153
Ensembl chr 5:196,868...218,153 		JBrowse link
G CCN3 cellular communication network factor 3 decreases expression ISO Mannitol results in decreased expression of CCN3 mRNA CTD PMID:25270620 NCBI chr 8:119,416,446...119,424,434
Ensembl chr 8:119,416,446...119,424,434 		JBrowse link
G CKAP5 cytoskeleton associated protein 5 increases expression ISO Mannitol results in increased expression of CKAP5 mRNA CTD PMID:25270620 NCBI chr11:46,743,048...46,846,280
Ensembl chr11:46,743,048...46,846,308 		JBrowse link
G CLCN3 chloride voltage-gated channel 3 affects response to substance EXP CLCN3 protein affects the susceptibility to Mannitol deficiency CTD PMID:22108225 NCBI chr 4:169,620,578...169,723,673
Ensembl chr 4:169,612,633...169,723,673 		JBrowse link
G CTNNA2 catenin alpha 2 decreases expression ISO Mannitol results in decreased expression of CTNNA2 mRNA CTD PMID:25270620 NCBI chr 2:79,185,377...80,648,780
Ensembl chr 2:79,185,231...80,648,861 		JBrowse link
G DBH dopamine beta-hydroxylase increases expression ISO Mannitol results in increased expression of DBH mRNA CTD PMID:25270620 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329 		JBrowse link
G DCTN2 dynactin subunit 2 increases expression ISO Mannitol results in increased expression of DCTN2 mRNA CTD PMID:25270620 NCBI chr12:57,530,051...57,547,192
Ensembl chr12:57,529,633...57,547,224 		JBrowse link
G DEFB4B defensin beta 4B decreases expression ISO Mannitol results in decreased expression of DEFB7 mRNA CTD PMID:25270620 NCBI chr 8:7,414,855...7,416,863
Ensembl chr 8:7,414,855...7,416,863
Ensembl chr 8:7,414,855...7,416,863 		JBrowse link
G DGKA diacylglycerol kinase alpha increases expression ISO Mannitol results in increased expression of DGKA mRNA CTD PMID:25270620 NCBI chr12:55,927,316...55,954,023
Ensembl chr12:55,927,319...55,954,027 		JBrowse link
G ELF2 E74 like ETS transcription factor 2 increases expression ISO Mannitol results in increased expression of ELF2 mRNA CTD PMID:25270620 NCBI chr 4:139,057,220...139,177,915
Ensembl chr 4:139,028,112...139,177,218 		JBrowse link
G FAM185A family with sequence similarity 185 member A increases expression ISO Mannitol results in increased expression of FAM185A mRNA CTD PMID:25270620 NCBI chr 7:102,748,999...102,850,723
Ensembl chr 7:102,748,971...102,809,225 		JBrowse link
G FAM222A family with sequence similarity 222 member A decreases expression ISO Mannitol results in decreased expression of FAM222A mRNA CTD PMID:25270620 NCBI chr12:109,713,825...109,770,495
Ensembl chr12:109,713,825...109,770,495 		JBrowse link
G FGF23 fibroblast growth factor 23 decreases expression
multiple interactions
decreases export		 ISO Mannitol results in decreased expression of FGF23 mRNA
Mannitol inhibits the reaction [Sodium Chloride deficiency results in increased expression of FGF23 mRNA]; Mannitol inhibits the reaction [Sodium Chloride deficiency results in increased expression of FGF23 protein]
Mannitol results in decreased export of FGF23 protein		 CTD PMID:37992803 NCBI chr12:4,368,227...4,379,712
Ensembl chr12:4,368,227...4,379,712 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Mannitol results in increased expression of FOS mRNA CTD PMID:11557636 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190 		JBrowse link
G GAL3ST2 galactose-3-O-sulfotransferase 2 decreases expression ISO Mannitol results in decreased expression of GAL3ST2 mRNA CTD PMID:25270620 NCBI chr 2:241,776,822...241,804,287
Ensembl chr 2:241,776,822...241,804,287 		JBrowse link
G GAS2L2 growth arrest specific 2 like 2 decreases expression ISO Mannitol results in decreased expression of GAS2L2 mRNA CTD PMID:25270620 NCBI chr17:35,744,511...35,753,239
Ensembl chr17:35,744,511...35,753,239 		JBrowse link
G GPC6 glypican 6 increases expression ISO Mannitol results in increased expression of GPC6 mRNA CTD PMID:25270620 NCBI chr13:93,216,529...94,408,020
Ensembl chr13:93,226,807...94,408,020 		JBrowse link
G GPR19 G protein-coupled receptor 19 decreases expression ISO Mannitol results in decreased expression of GPR19 mRNA CTD PMID:25270620 NCBI chr12:12,660,890...12,717,246
Ensembl chr12:12,660,890...12,696,207 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO Mannitol results in increased expression of HMOX1 mRNA CTD PMID:11592956 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 increases expression ISO Mannitol results in increased expression of HPRT1 mRNA CTD PMID:25270620 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513 		JBrowse link
G HRH2 histamine receptor H2 increases expression ISO Mannitol results in increased expression of HRH2 mRNA CTD PMID:25270620 NCBI chr 5:175,658,071...175,710,756
Ensembl chr 5:175,658,030...175,710,756 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 protein] CTD PMID:16285992 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP IGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein] CTD PMID:10567913 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO Mannitol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Rotenone inhibits the reaction [Mannitol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]] CTD PMID:23867654 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Mannitol results in increased expression of JUN mRNA CTD PMID:11557636 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G KHDC3L KH domain containing 3 like, subcortical maternal complex member increases expression ISO Mannitol results in increased expression of KHDC3 mRNA CTD PMID:25270620 NCBI chr 6:73,362,658...73,364,171
Ensembl chr 6:73,362,658...73,364,171 		JBrowse link
G KRTAP11-1 keratin associated protein 11-1 increases expression ISO Mannitol results in increased expression of KRTAP11-1 mRNA CTD PMID:25270620 NCBI chr21:30,880,644...30,881,580
Ensembl chr21:30,880,644...30,881,580 		JBrowse link
G LSM6 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO Mannitol results in decreased expression of LSM6 mRNA CTD PMID:25270620 NCBI chr 4:146,175,718...146,191,535
Ensembl chr 4:146,175,703...146,200,000 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 multiple interactions ISO Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein] CTD PMID:16510265 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 multiple interactions ISO Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein] CTD PMID:16510265 NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Mannitol promotes the reaction [potassium chromate(VI) results in increased phosphorylation of MAPK1 protein] CTD PMID:10910949 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Mannitol promotes the reaction [potassium chromate(VI) results in increased phosphorylation of MAPK8 protein] CTD PMID:10910949 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MTA2 metastasis associated 1 family member 2 increases expression ISO Mannitol results in increased expression of MTA2 mRNA CTD PMID:25270620 NCBI chr11:62,593,214...62,601,865
Ensembl chr11:62,593,214...62,601,865 		JBrowse link
G MYL9 myosin light chain 9 decreases phosphorylation ISO Mannitol results in decreased phosphorylation of MYL9 protein CTD PMID:17272349 NCBI chr20:36,541,519...36,551,447
Ensembl chr20:36,541,497...36,551,447 		JBrowse link
G MYLK3 myosin light chain kinase 3 increases expression ISO Mannitol results in increased expression of MYLK3 mRNA CTD PMID:25270620 NCBI chr16:46,702,282...46,763,246
Ensembl chr16:46,702,282...46,790,407 		JBrowse link
G NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 increases expression ISO Mannitol results in increased expression of NAALAD2 mRNA CTD PMID:25270620 NCBI chr11:90,131,699...90,192,894
Ensembl chr11:90,131,515...90,192,894 		JBrowse link
G NDUFA13 NADH:ubiquinone oxidoreductase subunit A13 decreases expression ISO Mannitol results in decreased expression of NDUFA13 mRNA CTD PMID:25270620 NCBI chr19:19,516,225...19,528,198
Ensembl chr19:19,515,736...19,529,054 		JBrowse link
G NFAT5 nuclear factor of activated T cells 5 increases expression
multiple interactions		 ISO Mannitol results in increased expression of NFAT5 mRNA
Mannitol inhibits the reaction [Sodium Chloride deficiency results in decreased expression of NFAT5 mRNA]
Mannitol results in increased expression of NFAT5 mRNA; Mannitol results in increased expression of NFAT5 protein		 CTD PMID:23867654 PMID:37992803 NCBI chr16:69,565,966...69,704,654
Ensembl chr16:69,565,094...69,704,666 		JBrowse link
G NKG7 natural killer cell granule protein 7 increases expression ISO Mannitol results in increased expression of NKG7 mRNA CTD PMID:25270620 NCBI chr19:51,371,620...51,372,654
Ensembl chr19:51,371,606...51,372,701 		JBrowse link
G NPPA natriuretic peptide A increases expression EXP Mannitol results in increased expression of NPPA protein CTD PMID:2177369 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G NTS neurotensin increases transport ISO NTS protein results in increased transport of Mannitol CTD PMID:11208724 NCBI chr12:85,874,295...85,882,992
Ensembl chr12:85,874,295...85,882,992 		JBrowse link
G OAT ornithine aminotransferase multiple interactions ISO Mannitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976 		JBrowse link
G PCP2 Purkinje cell protein 2 increases expression ISO Mannitol results in increased expression of PCP2 mRNA CTD PMID:25270620 NCBI chr19:7,631,615...7,637,006
Ensembl chr19:7,631,611...7,633,719 		JBrowse link
G PDCD4 programmed cell death 4 increases expression
decreases expression		 EXP Mannitol results in increased expression of PDCD4 mRNA
Mannitol results in decreased expression of PDCD4 mRNA		 CTD PMID:21873647 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006 		JBrowse link
G PHEX phosphate regulating endopeptidase X-linked increases expression ISO Mannitol results in increased expression of PHEX mRNA CTD PMID:37992803 NCBI chr  X:22,032,325...22,251,310
Ensembl chr  X:22,032,325...22,494,713 		JBrowse link
G PLCL2 phospholipase C like 2 decreases expression ISO Mannitol results in decreased expression of PLCL2 mRNA CTD PMID:25270620 NCBI chr 3:16,884,955...17,090,606
Ensembl chr 3:16,802,651...17,090,604 		JBrowse link
G PLEKHO1 pleckstrin homology domain containing O1 increases expression ISO Mannitol results in increased expression of PLEKHO1 mRNA CTD PMID:25270620 NCBI chr 1:150,149,646...150,160,065
Ensembl chr 1:150,149,183...150,164,720 		JBrowse link
G POU1F1 POU class 1 homeobox 1 increases expression ISO Mannitol results in increased expression of POU1F1 mRNA CTD PMID:25270620 NCBI chr 3:87,259,404...87,276,584
Ensembl chr 3:87,259,404...87,276,584 		JBrowse link
G PPP1R10 protein phosphatase 1 regulatory subunit 10 decreases expression ISO Mannitol results in decreased expression of PPP1R10 mRNA CTD PMID:25270620 NCBI chr 6:30,600,413...30,617,243
Ensembl chr 6:30,600,413...30,618,612 		JBrowse link
G PPP4C protein phosphatase 4 catalytic subunit increases expression ISO Mannitol results in increased expression of PPP4C mRNA CTD PMID:25270620 NCBI chr16:30,075,994...30,085,376
Ensembl chr16:30,075,978...30,085,376 		JBrowse link
G PRKCB protein kinase C beta multiple interactions EXP Mannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]; Mannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein] CTD PMID:16285992 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611 		JBrowse link
G PRKCD protein kinase C delta multiple interactions EXP Mannitol inhibits the reaction [Glucose results in increased expression of PRKCD protein] CTD PMID:16285992 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
G PTGER1 prostaglandin E receptor 1 increases expression ISO Mannitol results in increased expression of PTGER1 mRNA CTD PMID:12888618 NCBI chr19:14,472,466...14,475,354
Ensembl chr19:14,472,466...14,475,354 		JBrowse link
G PTGER4 prostaglandin E receptor 4 decreases expression ISO Mannitol results in decreased expression of PTGER4 mRNA CTD PMID:12888618 NCBI chr 5:40,679,915...40,746,800
Ensembl chr 5:40,679,915...40,693,735 		JBrowse link
G PTK2 protein tyrosine kinase 2 multiple interactions EXP benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Mannitol results in decreased phosphorylation of and results in increased degradation of PTK2 protein]; Mannitol results in decreased phosphorylation of and results in increased degradation of PTK2 protein CTD PMID:12011046 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216 		JBrowse link
G RBL1 RB transcriptional corepressor like 1 decreases expression ISO Mannitol results in decreased expression of RBL1 mRNA CTD PMID:25270620 NCBI chr20:36,996,349...37,095,997
Ensembl chr20:36,996,349...37,095,997 		JBrowse link
G RBP2 retinol binding protein 2 decreases expression ISO Mannitol results in decreased expression of RBP2 mRNA CTD PMID:25270620 NCBI chr 3:139,452,884...139,476,516
Ensembl chr 3:139,452,884...139,480,747 		JBrowse link
G RGL3 ral guanine nucleotide dissociation stimulator like 3 increases expression ISO Mannitol results in increased expression of RGL3 mRNA CTD PMID:25270620 NCBI chr19:11,394,060...11,419,314
Ensembl chr19:11,384,341...11,419,328 		JBrowse link
G SAMD10 sterile alpha motif domain containing 10 decreases expression ISO Mannitol results in decreased expression of SAMD10 mRNA CTD PMID:25270620 NCBI chr20:63,974,116...63,980,144
Ensembl chr20:63,974,116...63,980,008 		JBrowse link
G SBSN suprabasin decreases expression ISO Mannitol results in decreased expression of SBSN mRNA CTD PMID:25270620 NCBI chr19:35,523,367...35,528,311
Ensembl chr19:35,523,367...35,528,351 		JBrowse link
G SELE selectin E multiple interactions EXP Mannitol inhibits the reaction [Glucose results in increased expression of SELE mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of SELE protein] CTD PMID:16285992 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SGSM3 small G protein signaling modulator 3 decreases expression ISO Mannitol results in decreased expression of SGSM3 mRNA CTD PMID:25270620 NCBI chr22:40,370,594...40,410,289
Ensembl chr22:40,370,591...40,410,289 		JBrowse link
G SLC12A1 solute carrier family 12 member 1 increases activity
multiple interactions		 ISO Mannitol results in increased activity of SLC12A1 protein
[Mannitol results in increased activity of SLC12A1 protein] which results in increased import of Water		 CTD PMID:12433675 NCBI chr15:48,206,302...48,304,078
Ensembl chr15:48,178,438...48,304,078 		JBrowse link
G SLC2A8 solute carrier family 2 member 8 decreases expression ISO Mannitol results in decreased expression of SLC2A8 mRNA CTD PMID:25270620 NCBI chr 9:127,397,169...127,407,898
Ensembl chr 9:127,397,138...127,408,424 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of SRC protein] CTD PMID:16510265 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G STX8 syntaxin 8 decreases expression ISO Mannitol results in decreased expression of STX8 mRNA CTD PMID:25270620 NCBI chr17:9,250,471...9,575,820
Ensembl chr17:9,250,471...9,576,591 		JBrowse link
G TIMD4 T cell immunoglobulin and mucin domain containing 4 decreases expression ISO Mannitol results in decreased expression of TIMD4 mRNA CTD PMID:25270620 NCBI chr 5:156,919,292...156,963,226
Ensembl chr 5:156,919,292...156,963,226 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Mannitol inhibits the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]; Mannitol inhibits the reaction [Quartz results in increased secretion of TNF protein] CTD PMID:19298665 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 increases expression EXP Mannitol results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314 		JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein] CTD PMID:29803612 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TPD52 tumor protein D52 decreases expression
increases expression		 EXP Mannitol results in decreased expression of TPD52 mRNA
Mannitol results in increased expression of TPD52 mRNA		 CTD PMID:21873647 NCBI chr 8:80,031,082...80,171,564
Ensembl chr 8:80,034,745...80,231,232 		JBrowse link
G TRIML1 tripartite motif family like 1 increases expression ISO Mannitol results in increased expression of TRIML1 mRNA CTD PMID:25270620 NCBI chr 4:188,137,229...188,150,767
Ensembl chr 4:188,139,441...188,147,743 		JBrowse link
G ULBP1 UL16 binding protein 1 increases expression ISO Mannitol results in increased expression of ULBP1 mRNA CTD PMID:25270620 NCBI chr 6:149,963,943...149,973,715
Ensembl chr 6:149,963,943...149,973,715 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP Mannitol inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of VCAM1 protein] CTD PMID:16285992 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G WDR20 WD repeat domain 20 decreases expression ISO Mannitol results in decreased expression of WDR20 mRNA CTD PMID:25270620 NCBI chr14:102,139,423...102,224,839
Ensembl chr14:102,139,503...102,224,847 		JBrowse link
G ZG16 zymogen granule protein 16 decreases expression ISO Mannitol results in decreased expression of ZG16 mRNA CTD PMID:25270620 NCBI chr16:29,778,256...29,782,973
Ensembl chr16:29,778,256...29,782,973 		JBrowse link
G ZNF205 zinc finger protein 205 decreases expression ISO Mannitol results in decreased expression of ZFP13 mRNA CTD PMID:25270620 NCBI chr16:3,112,586...3,120,517
Ensembl chr16:3,112,560...3,120,517 		JBrowse link
sodium hydrogencarbonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 increases expression ISO Sodium Bicarbonate results in increased expression of ABCC2 mRNA CTD PMID:29126803 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) decreases expression ISO Sodium Bicarbonate results in decreased expression of ABCG2 mRNA CTD PMID:29126803 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G CA2 carbonic anhydrase 2 decreases expression ISO Sodium Bicarbonate results in decreased expression of CAR2 mRNA CTD PMID:31569818 NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493 		JBrowse link
G CAT catalase multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in decreased activity of CAT protein CTD PMID:25559736 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G FN1 fibronectin 1 multiple interactions ISO Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] CTD PMID:10430982 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G NEFH neurofilament heavy chain affects expression ISO Sodium Bicarbonate affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390 		JBrowse link
G NFKB2 nuclear factor kappa B subunit 2 multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of NFKB2 mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of NFKB2 mRNA] CTD PMID:25559736 NCBI chr10:102,394,110...102,402,529
Ensembl chr10:102,394,110...102,402,524 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of RELA protein; [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of RELA mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of RELA mRNA] CTD PMID:25559736 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SLC15A1 solute carrier family 15 member 1 decreases expression ISO Sodium Bicarbonate results in decreased expression of SLC15A1 mRNA CTD PMID:29126803 NCBI chr13:98,683,801...98,752,672
Ensembl chr13:98,683,801...98,752,672 		JBrowse link
G SLC22A24 solute carrier family 22 member 24 increases expression ISO Sodium Bicarbonate results in increased expression of SLC22A24 mRNA CTD PMID:29126803 NCBI chr11:63,079,940...63,144,221
Ensembl chr11:63,079,940...63,144,221 		JBrowse link
G SLC22A6 solute carrier family 22 member 6 decreases expression ISO Sodium Bicarbonate results in decreased expression of SLC22A6 mRNA CTD PMID:29126803 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967 		JBrowse link
G SLC39A8 solute carrier family 39 member 8 multiple interactions ISO SLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of Cadmium Chloride]; SLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of manganese chloride] CTD PMID:21509381 NCBI chr 4:102,251,041...102,345,482
Ensembl chr 4:102,251,080...102,431,258 		JBrowse link
G SLC4A1 solute carrier family 4 member 1 (Diego blood group) decreases expression ISO Sodium Bicarbonate results in decreased expression of SLC4A1 mRNA CTD PMID:31569818 NCBI chr17:44,248,390...44,268,135
Ensembl chr17:44,248,390...44,268,141 		JBrowse link
G SLC4A4 solute carrier family 4 member 4 increases transport
decreases expression		 EXP
ISO		 SLC4A4 protein results in increased transport of Sodium Bicarbonate
Sodium Bicarbonate results in decreased expression of SLC4A4 mRNA		 CTD PMID:18614622 PMID:31569818 NCBI chr 4:71,062,660...71,572,083
Ensembl chr 4:71,062,667...71,572,087 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA] CTD PMID:10430982 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TNF mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TNF mRNA] CTD PMID:25559736 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein; [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA] CTD PMID:25559736 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G VIM vimentin multiple interactions ISO Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of VIM protein] CTD PMID:10430982 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26496
    role 26318
      application 25582
        food additive 19089
          food anticaking agent 208
            D-mannitol + 94
            calcium silicate 104
            dimethicone polymer 0
            potassium bitartrate 0
            sodium hydrogencarbonate 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 26496
    role 26318
      biological role 26297
        physiological role 26276
          food component 26276
            food additive 19089
              food anticaking agent 208
                D-mannitol + 94
                calcium silicate 104
                dimethicone polymer 0
                potassium bitartrate 0
                sodium hydrogencarbonate 18
paths to the root