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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole
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Accession:CHEBI:77776 term browser browse the term
Definition:A member of the class of imidazoles that is 1-ethyl-1H-imidazole in which one of the hydrogens of the methyl group is replaced by a (4-chlorobenzyl)sulfanediyl group while a second is replaced by a 2,4-dichlorophenyl group.
Synonyms:related_synonym: Formula=C18H15Cl3N2S;   InChI=1S/C18H15Cl3N2S/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2;   InChIKey=AFNXATANNDIXLG-UHFFFAOYSA-N;   SMILES=Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1
 xref: CAS:61318-90-9;   KEGG:C08076;   KEGG:D08535;   LINCS:LSM-1751
 xref_mesh: MESH:C033308


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1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO sulconazole results in increased expression of ABCB1 mRNA CTD PMID:31312845 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions		 ISO sulconazole results in increased expression of CYP2B6 mRNA
[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA		 CTD PMID:31312845 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO sulconazole results in increased expression of CYP3A4 mRNA
[sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:31312845 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO sulconazole results in decreased expression of FASN mRNA CTD PMID:31312845 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO sulconazole results in decreased expression of G6PC1 mRNA CTD PMID:31312845 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO sulconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form] CTD PMID:31312845 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO sulconazole results in increased activity of NR1I2 protein
[sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:31312845 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
multiple interactions
affects binding		 ISO sulconazole affects the localization of NR1I3 protein mutant form
[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; sulconazole binds to and results in increased activity of NR1I3 protein alternative form; sulconazole inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]
sulconazole binds to NR1I3 protein		 CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 affects expression ISO sulconazole affects the expression of PCK1 mRNA CTD PMID:31312845 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO sulconazole results in decreased expression of SCD mRNA CTD PMID:31312845 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO sulconazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Thrsp thyroid hormone responsive affects expression ISO sulconazole affects the expression of THRSP mRNA CTD PMID:31312845 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075 		JBrowse link
sulconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO sulconazole results in increased expression of ABCB1 mRNA CTD PMID:31312845 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions		 ISO sulconazole results in increased expression of CYP2B6 mRNA
[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA		 CTD PMID:31312845 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO sulconazole results in increased expression of CYP3A4 mRNA
[sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:31312845 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO sulconazole results in decreased expression of FASN mRNA CTD PMID:31312845 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO sulconazole results in decreased expression of G6PC1 mRNA CTD PMID:31312845 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO sulconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form] CTD PMID:31312845 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO [sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:31312845 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
multiple interactions
affects binding		 ISO sulconazole affects the localization of NR1I3 protein mutant form
[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; sulconazole binds to and results in increased activity of NR1I3 protein alternative form; sulconazole inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]
sulconazole binds to NR1I3 protein		 CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 affects expression ISO sulconazole affects the expression of PCK1 mRNA CTD PMID:31312845 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO sulconazole results in decreased expression of SCD mRNA CTD PMID:31312845 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO sulconazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Thrsp thyroid hormone responsive affects expression ISO sulconazole affects the expression of THRSP mRNA CTD PMID:31312845 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          sulfur atom 17752
            sulfur molecular entity 17752
              sulfide 10111
                organic sulfide 10111
                  1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole 13
                    (R)-sulconazole + 13
                    (S)-sulconazole + 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  heteroarene 17155
                                    monocyclic heteroarene 14983
                                      azole 14506
                                        diazole 10772
                                          imidazoles 10221
                                            1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole 13
                                              (R)-sulconazole + 13
                                              (S)-sulconazole + 13
paths to the root