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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor
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Accession:CHEBI:77758 term browser browse the term
Definition:An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of a 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53).
Synonyms:related_synonym: 3',5'-cyclic-AMP 5'-nucleotidohydrolase inhibitor;   3',5'-cyclic-AMP 5'-nucleotidohydrolase inhibitors;   3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53) inhibitors;   3',5'-cyclic-AMP phosphodiesterase inhibitor;   3',5'-cyclic-AMP phosphodiesterase inhibitors;   EC 3.1.4.53 inhibitor;   EC 3.1.4.53 inhibitors;   cAMP-specific PDE inhibitor;   cAMP-specific PDE inhibitors;   cAMP-specific phosphodiesterase inhibitor;   cAMP-specific phosphodiesterase inhibitors
 xref: wikipedia.en:3'\,5'-cyclic-AMP_phosphodiesterase


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apremilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased activity of CASP3 protein] CTD PMID:27785949 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of CKM protein] CTD PMID:27785949 NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of GOT1 protein] CTD PMID:27785949 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of LDHA protein] CTD PMID:27785949 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK1 mRNA] CTD PMID:27785949 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK8 mRNA] CTD PMID:27785949 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in decreased expression of NFKBIA protein] CTD PMID:27785949 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of RELA mRNA] CTD PMID:27785949 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
etazolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 decreases expression
decreases secretion 		ISO Etazolate results in decreased expression of IL13 mRNA
Etazolate results in decreased secretion of IL13 protein 		CTD PMID:16083514 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Ltc4s leukotriene C4 synthase decreases secretion ISO Etazolate results in decreased secretion of LTC4S protein CTD PMID:16083514 NCBI chr10:35,060,002...35,066,466
Ensembl chr10:35,061,437...35,063,768 		JBrowse link
piclamilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein] CTD PMID:34627785 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of BAX mRNA] CTD PMID:34627785 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of BCL2 mRNA] CTD PMID:34627785 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 mRNA] CTD PMID:34627785 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein] CTD PMID:34627785 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of piclamilast CTD PMID:12464242 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP piclamilast inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:73,164,096...73,175,180
Ensembl chr10:73,164,096...73,175,180 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of IL1B protein] CTD PMID:34627785 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of MTOR protein] CTD PMID:34627785 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:34627785 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of RASGRF1 protein] CTD PMID:34627785 NCBI chr 8:99,324,986...99,454,099
Ensembl chr 8:99,324,749...99,454,089 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein] CTD PMID:34627785 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of TNF protein] CTD PMID:34627785 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
roflumilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:39197814 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation 		EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; RAPGEF3 mutant form inhibits the reaction [Roflumilast results in increased phosphorylation of AKT1 protein]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein] CTD PMID:18276108 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein] CTD PMID:31301536 NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504 		JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein] CTD PMID:31301536 NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in increased expression of ATF6 protein] CTD PMID:37105514 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		EXP
ISO 		Roflumilast inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Roflumilast inhibits the reaction [Cisplatin results in increased expression of BAX protein]
Roflumilast results in increased expression of BAX mRNA; Roflumilast results in increased expression of BAX protein
[Cisplatin co-treated with Roflumilast] results in increased expression of BAX mRNA; Cisplatin promotes the reaction [Roflumilast results in increased expression of BAX mRNA]; Cisplatin promotes the reaction [Roflumilast results in increased expression of BAX protein]; Roflumilast promotes the reaction [Cisplatin results in increased expression of BAX protein] 		CTD PMID:33757793 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		ISO
EXP 		Cisplatin promotes the reaction [Roflumilast results in decreased expression of BCL2 mRNA]; Cisplatin promotes the reaction [Roflumilast results in decreased expression of BCL2 protein]; Roflumilast promotes the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Roflumilast promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]
Roflumilast inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Roflumilast inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
Roflumilast results in decreased expression of BCL2 mRNA; Roflumilast results in decreased expression of BCL2 protein 		CTD PMID:33757793 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in decreased expression of BDNF protein] CTD PMID:36706892 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity
decreases expression 		ISO
EXP 		Roflumilast results in increased expression of CASP3 mRNA
[Cisplatin co-treated with Roflumilast] results in increased expression of CASP3 mRNA; Cisplatin promotes the reaction [Roflumilast results in increased activity of CASP3 protein]; Cisplatin promotes the reaction [Roflumilast results in increased expression of CASP3 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased activity of CASP3 protein]
Roflumilast inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Roflumilast inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; Roflumilast inhibits the reaction [Rotenone results in increased expression of CASP3 protein]
Roflumilast results in decreased expression of CASP3 protein 		CTD PMID:33757793 PMID:37105514 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase multiple interactions EXP Roflumilast inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Roflumilast inhibits the reaction [Rotenone results in decreased activity of CAT protein] CTD PMID:33757793 PMID:36706892 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:21913898 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:21913898 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein] CTD PMID:21913898 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein] CTD PMID:39197814 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CDKN1A protein] CTD PMID:39197814 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein] CTD PMID:31301536 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643 		JBrowse link
G Cnn1 calponin 1 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CNN1 protein] CTD PMID:39197814 NCBI chr 8:28,908,437...28,917,099
Ensembl chr 8:28,908,330...28,919,482 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of COL1A1 mRNA]; Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of COL1A1 protein]
Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] 		CTD PMID:39197814 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation 		EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; Roflumilast inhibits the reaction [Rotenone results in decreased phosphorylation of CREB1 protein]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]
Roflumilast results in increased phosphorylation of CREB1 protein 		CTD PMID:18276108 PMID:36706892 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein] CTD PMID:21913898 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in increased expression of DDIT3 protein] CTD PMID:37105514 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Fap fibroblast activation protein, alpha multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of FAP protein] CTD PMID:39197814 NCBI chr 3:67,547,398...67,616,271
Ensembl chr 3:67,546,921...67,617,601 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of FN1 protein]
Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein] 		CTD PMID:39197814 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased activity of GLB1 protein] CTD PMID:39197814 NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression 		ISO
EXP 		Cisplatin promotes the reaction [Roflumilast results in increased expression of HMOX1 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]
Roflumilast inhibits the reaction [Rotenone results in decreased expression of HMOX1 protein]; Roflumilast promotes the reaction [Cisplatin results in increased activity of HMOX1 protein]; Roflumilast promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA] 		CTD PMID:33757793 PMID:37105514 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Roflumilast inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:33757793 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in increased expression of IL6 protein] CTD PMID:36706892 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]]
Roflumilast inhibits the reaction [Hypochlorous Acid results in increased phosphorylation of MAPK1 protein] 		CTD PMID:39197814 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Roflumilast inhibits the reaction [Hypochlorous Acid results in increased phosphorylation of MAPK3 protein]
KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]] 		CTD PMID:39197814 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression 		EXP
ISO 		[Roflumilast co-treated with Rotenone] results in increased expression of and results in increased localization of NFE2L2 protein; Roflumilast promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]
Roflumilast results in increased expression of NFE2L2 mRNA
Cisplatin promotes the reaction [Roflumilast results in increased expression of NFE2L2 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA] 		CTD PMID:33757793 PMID:37105514 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in decreased expression of NGF protein] CTD PMID:36706892 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein] CTD PMID:39197814 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression 		ISO
EXP 		Cisplatin promotes the reaction [Roflumilast results in increased expression of NQO1 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] CTD PMID:33757793 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Pde3a phosphodiesterase 3A decreases activity ISO Roflumilast results in decreased activity of PDE3A protein CTD PMID:15901792 NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:175,904,077...176,169,270 		JBrowse link
G Pde3b phosphodiesterase 3B decreases activity ISO Roflumilast results in decreased activity of PDE3B protein CTD PMID:15901792 NCBI chr 1:178,041,207...178,204,503
Ensembl chr 1:178,041,207...178,204,503 		JBrowse link
G Pde4a phosphodiesterase 4A decreases activity
multiple interactions 		ISO
EXP 		Roflumilast results in decreased activity of PDE4A protein
Roflumilast inhibits the reaction [Rotenone results in increased activity of PDE4A protein] 		CTD PMID:15901792 PMID:36706892 NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:27,966,996...28,046,924 		JBrowse link
G Pde4b phosphodiesterase 4B decreases activity
multiple interactions 		ISO Roflumilast results in decreased activity of PDE4B protein
Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of PDE4B protein alternative form]
Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of PDE4B protein alternative form] 		CTD PMID:15901792 PMID:39197814 NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267 		JBrowse link
G Pde4c phosphodiesterase 4C decreases activity ISO Roflumilast results in decreased activity of PDE4C protein CTD PMID:15901792 NCBI chr16:18,724,703...18,745,528
Ensembl chr16:18,725,674...18,744,037 		JBrowse link
G Pde4d phosphodiesterase 4D decreases activity ISO Roflumilast results in decreased activity of PDE4D protein CTD PMID:15901792 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569 		JBrowse link
G Pde7a phosphodiesterase 7A decreases activity ISO Roflumilast results in decreased activity of PDE7A protein CTD PMID:15901792 NCBI chr 2:103,631,655...103,723,057
Ensembl chr 2:103,634,594...103,722,890 		JBrowse link
G Pde8b phosphodiesterase 8B decreases activity ISO Roflumilast results in decreased activity of PDE8B protein CTD PMID:15901792 NCBI chr 2:28,009,841...28,244,050
Ensembl chr 2:28,011,359...28,244,327 		JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in decreased expression of PPM1A protein] CTD PMID:39197814 NCBI chr 6:97,174,955...97,216,585
Ensembl chr 6:97,174,916...97,216,574 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in increased expression of PPP1CC protein] CTD PMID:36706892 NCBI chr12:40,043,822...40,061,301
Ensembl chr12:40,043,822...40,061,341 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in decreased phosphorylation of PPP1R1B protein] CTD PMID:36706892 NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,844,036...83,853,063 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in decreased expression of PRKACA protein] CTD PMID:36706892 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494 		JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 multiple interactions
increases expression 		EXP RAPGEF3 mutant form inhibits the reaction [Roflumilast results in increased phosphorylation of AKT1 protein]
Roflumilast results in increased expression of RAPGEF3 protein 		CTD PMID:18276108 NCBI chr 7:130,754,883...130,777,303
Ensembl chr 7:130,754,871...130,777,668 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression 		EXP
ISO 		Roflumilast inhibits the reaction [Cisplatin results in increased expression of RELA mRNA]; Roflumilast inhibits the reaction [Rotenone results in increased expression of RELA protein]
Roflumilast results in decreased expression of RELA mRNA
Cisplatin promotes the reaction [Roflumilast results in decreased expression of RELA mRNA] 		CTD PMID:33757793 PMID:36706892 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein] CTD PMID:39197814 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO Roflumilast inhibits the reaction [Hypochlorous Acid results in increased phosphorylation of SMAD3 protein]
KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] 		CTD PMID:39197814 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Snca synuclein alpha multiple interactions
increases degradation 		EXP Roflumilast inhibits the reaction [Rotenone results in increased expression of SNCA protein]
Roflumilast results in increased degradation of SNCA protein 		CTD PMID:37105514 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]]; KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]]; KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Roflumilast inhibits the reaction [TGFB1 protein results in decreased expression of PPM1A protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased activity of GLB1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CDKN1A protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CNN1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of FAP protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of PDE4B protein alternative form]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]
Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of TGFB1 mRNA] 		CTD PMID:39197814 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Roflumilast inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Roflumilast inhibits the reaction [Rotenone results in increased expression of TNF protein] 		CTD PMID:21913898 PMID:33757793 PMID:36706892 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
SCH-351591 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amy2a3 amylase 2a3 increases expression EXP SCH 351591 results in increased expression of AMY1A mRNA CTD PMID:20585143 NCBI chr 2:204,005,840...204,014,412
Ensembl chr 2:204,005,840...204,014,413 		JBrowse link
G Ctrl chymotrypsin-like increases expression EXP SCH 351591 results in increased expression of CTRL mRNA CTD PMID:20585143 NCBI chr19:50,737,078...50,740,659
Ensembl chr19:50,737,079...50,738,979 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP SCH 351591 results in increased expression of CXCL1 protein CTD PMID:20585143 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP SCH 351591 results in increased expression of DBP mRNA CTD PMID:20585143 NCBI chr 1:105,312,256...105,317,205
Ensembl chr 1:105,312,108...105,317,205 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression EXP SCH 351591 results in increased expression of NR1D1 mRNA CTD PMID:20585143 NCBI chr10:84,224,599...84,231,812
Ensembl chr10:84,224,540...84,231,812 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP SCH 351591 results in increased expression of NR1D2 mRNA CTD PMID:20585143 NCBI chr15:9,955,034...9,981,329
Ensembl chr15:9,954,906...9,981,330 		JBrowse link
G Per1 period circadian regulator 1 increases expression EXP SCH 351591 results in increased expression of PER1 mRNA CTD PMID:20585143 NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211 		JBrowse link
G Prss1 serine protease 1 increases expression EXP SCH 351591 results in increased expression of PRSS1 mRNA CTD PMID:20585143 NCBI chr 4:71,331,249...71,334,452
Ensembl chr 4:71,331,246...71,334,452 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        biochemical role 19888
          enzyme inhibitor 18710
            EC 3.* (hydrolase) inhibitor 17214
              EC 3.1.* (ester hydrolase) inhibitor 14877
                EC 3.1.4.* (phosphoric diester hydrolase) inhibitor 4341
                  EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor 72
                    BRL-50481 0
                    phosphodiesterase IV inhibitor + 72
paths to the root