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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor
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Accession:CHEBI:77758 term browser browse the term
Definition:An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of a 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53).
Synonyms:related_synonym: 3',5'-cyclic-AMP 5'-nucleotidohydrolase inhibitor;   3',5'-cyclic-AMP 5'-nucleotidohydrolase inhibitors;   3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53) inhibitors;   3',5'-cyclic-AMP phosphodiesterase inhibitor;   3',5'-cyclic-AMP phosphodiesterase inhibitors;   EC 3.1.4.53 inhibitor;   EC 3.1.4.53 inhibitors;   cAMP-specific PDE inhibitor;   cAMP-specific PDE inhibitors;   cAMP-specific phosphodiesterase inhibitor;   cAMP-specific phosphodiesterase inhibitors
 xref: Wikipedia:3'\,5'-cyclic-AMP_phosphodiesterase


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apremilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased activity of CASP3 protein] CTD PMID:27785949 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of CKM protein] CTD PMID:27785949 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of GOT1 protein] CTD PMID:27785949 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of LDHA protein] CTD PMID:27785949 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK1 mRNA] CTD PMID:27785949 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK8 mRNA] CTD PMID:27785949 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in decreased expression of NFKBIA protein] CTD PMID:27785949 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of RELA mRNA] CTD PMID:27785949 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
etazolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 decreases expression
decreases secretion		 ISO Etazolate results in decreased expression of IL13 mRNA
Etazolate results in decreased secretion of IL13 protein		 CTD PMID:16083514 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Ltc4s leukotriene C4 synthase decreases secretion ISO Etazolate results in decreased secretion of LTC4S protein CTD PMID:16083514 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
piclamilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein] CTD PMID:34627785 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of BAX mRNA] CTD PMID:34627785 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of BCL2 mRNA] CTD PMID:34627785 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 mRNA] CTD PMID:34627785 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein] CTD PMID:34627785 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of piclamilast CTD PMID:12464242 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP piclamilast inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of IL1B protein] CTD PMID:34627785 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of MTOR protein] CTD PMID:34627785 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:34627785 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of RASGRF1 protein] CTD PMID:34627785 NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein] CTD PMID:34627785 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP piclamilast inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of TNF protein] CTD PMID:34627785 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
roflumilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:39197814 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; RAPGEF3 mutant form inhibits the reaction [Roflumilast results in increased phosphorylation of AKT1 protein]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein] CTD PMID:18276108 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein] CTD PMID:31301536 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein] CTD PMID:31301536 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in increased expression of ATF6 protein] CTD PMID:37105514 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 Roflumilast inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Roflumilast inhibits the reaction [Cisplatin results in increased expression of BAX protein]
[Cisplatin co-treated with Roflumilast] results in increased expression of BAX mRNA; Cisplatin promotes the reaction [Roflumilast results in increased expression of BAX mRNA]; Cisplatin promotes the reaction [Roflumilast results in increased expression of BAX protein]; Roflumilast promotes the reaction [Cisplatin results in increased expression of BAX protein]
Roflumilast results in increased expression of BAX mRNA; Roflumilast results in increased expression of BAX protein		 CTD PMID:33757793 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO
EXP		 Cisplatin promotes the reaction [Roflumilast results in decreased expression of BCL2 mRNA]; Cisplatin promotes the reaction [Roflumilast results in decreased expression of BCL2 protein]; Roflumilast promotes the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Roflumilast promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]
Roflumilast results in decreased expression of BCL2 mRNA; Roflumilast results in decreased expression of BCL2 protein
Roflumilast inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Roflumilast inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]		 CTD PMID:33757793 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in decreased expression of BDNF protein] CTD PMID:36706892 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 increases expression
decreases expression
increases activity
multiple interactions		 ISO
EXP		 Roflumilast results in increased expression of CASP3 mRNA
Roflumilast results in decreased expression of CASP3 protein
Roflumilast results in increased activity of CASP3 protein
Roflumilast inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Roflumilast inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; Roflumilast inhibits the reaction [Rotenone results in increased expression of CASP3 protein]
[Cisplatin co-treated with Roflumilast] results in increased expression of CASP3 mRNA; Cisplatin promotes the reaction [Roflumilast results in increased activity of CASP3 protein]; Cisplatin promotes the reaction [Roflumilast results in increased expression of CASP3 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased activity of CASP3 protein]		 CTD PMID:33757793 PMID:37105514 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Roflumilast inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Roflumilast inhibits the reaction [Rotenone results in decreased activity of CAT protein] CTD PMID:33757793 PMID:36706892 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:21913898 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:21913898 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein] CTD PMID:21913898 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein] CTD PMID:39197814 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CDKN1A protein] CTD PMID:39197814 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein] CTD PMID:31301536 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Cnn1 calponin 1 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CNN1 protein] CTD PMID:39197814 NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of COL1A1 mRNA]; Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of COL1A1 protein]
Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]		 CTD PMID:39197814 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation		 EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; Roflumilast inhibits the reaction [Rotenone results in decreased phosphorylation of CREB1 protein]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]
Roflumilast results in increased phosphorylation of CREB1 protein		 CTD PMID:18276108 PMID:36706892 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein] CTD PMID:21913898 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in increased expression of DDIT3 protein] CTD PMID:37105514 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Fap fibroblast activation protein, alpha multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of FAP protein] CTD PMID:39197814 NCBI chr 3:47,138,823...47,207,671
Ensembl chr 3:47,138,813...47,225,545 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of FN1 protein]
Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]		 CTD PMID:39197814 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased activity of GLB1 protein] CTD PMID:39197814 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 Cisplatin promotes the reaction [Roflumilast results in increased expression of HMOX1 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]
Roflumilast inhibits the reaction [Rotenone results in decreased expression of HMOX1 protein]; Roflumilast promotes the reaction [Cisplatin results in increased activity of HMOX1 protein]; Roflumilast promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]		 CTD PMID:33757793 PMID:37105514 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Roflumilast inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:33757793 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in increased expression of IL6 protein] CTD PMID:36706892 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]]
Roflumilast inhibits the reaction [Hypochlorous Acid results in increased phosphorylation of MAPK1 protein]		 CTD PMID:39197814 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Roflumilast inhibits the reaction [Hypochlorous Acid results in increased phosphorylation of MAPK3 protein]
KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]]		 CTD PMID:39197814 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 EXP
ISO		 [Roflumilast co-treated with Rotenone] results in increased expression of and results in increased localization of NFE2L2 protein; Roflumilast promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]
Roflumilast results in increased expression of NFE2L2 mRNA
Cisplatin promotes the reaction [Roflumilast results in increased expression of NFE2L2 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]		 CTD PMID:33757793 PMID:37105514 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in decreased expression of NGF protein] CTD PMID:36706892 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein] CTD PMID:39197814 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 ISO
EXP		 Cisplatin promotes the reaction [Roflumilast results in increased expression of NQO1 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] CTD PMID:33757793 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pde3a phosphodiesterase 3A decreases activity ISO Roflumilast results in decreased activity of PDE3A protein CTD PMID:15901792 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274 		JBrowse link
G Pde3b phosphodiesterase 3B decreases activity ISO Roflumilast results in decreased activity of PDE3B protein CTD PMID:15901792 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334 		JBrowse link
G Pde4a phosphodiesterase 4A decreases activity
multiple interactions		 ISO
EXP		 Roflumilast results in decreased activity of PDE4A protein
Roflumilast inhibits the reaction [Rotenone results in increased activity of PDE4A protein]		 CTD PMID:15901792 PMID:36706892 NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961 		JBrowse link
G Pde4b phosphodiesterase 4B decreases activity
multiple interactions		 ISO Roflumilast results in decreased activity of PDE4B protein
Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of PDE4B protein alternative form]
Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of PDE4B protein alternative form]		 CTD PMID:15901792 PMID:39197814 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pde4c phosphodiesterase 4C decreases activity ISO Roflumilast results in decreased activity of PDE4C protein CTD PMID:15901792 NCBI chr16:18,690,727...18,711,555
Ensembl chr16:18,691,700...18,710,640 		JBrowse link
G Pde4d phosphodiesterase 4D decreases activity ISO Roflumilast results in decreased activity of PDE4D protein CTD PMID:15901792 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pde7a phosphodiesterase 7A decreases activity ISO Roflumilast results in decreased activity of PDE7A protein CTD PMID:15901792 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681 		JBrowse link
G Pde8b phosphodiesterase 8B decreases activity ISO Roflumilast results in decreased activity of PDE8B protein CTD PMID:15901792 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209 		JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in decreased expression of PPM1A protein] CTD PMID:39197814 NCBI chr 6:91,439,094...91,486,139
Ensembl chr 6:91,438,834...91,480,697 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in increased expression of PPP1CC protein] CTD PMID:36706892 NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in decreased phosphorylation of PPP1R1B protein] CTD PMID:36706892 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Roflumilast inhibits the reaction [Rotenone results in decreased expression of PRKACA protein] CTD PMID:36706892 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 multiple interactions
increases expression		 EXP RAPGEF3 mutant form inhibits the reaction [Roflumilast results in increased phosphorylation of AKT1 protein]
Roflumilast results in increased expression of RAPGEF3 protein		 CTD PMID:18276108 NCBI chr 7:128,875,772...128,898,203
Ensembl chr 7:128,875,773...128,898,521 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 EXP
ISO		 Roflumilast inhibits the reaction [Cisplatin results in increased expression of RELA mRNA]; Roflumilast inhibits the reaction [Rotenone results in increased expression of RELA protein]
Roflumilast results in decreased expression of RELA mRNA
Cisplatin promotes the reaction [Roflumilast results in decreased expression of RELA mRNA]		 CTD PMID:33757793 PMID:36706892 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein] CTD PMID:39197814 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO Roflumilast inhibits the reaction [Hypochlorous Acid results in increased phosphorylation of SMAD3 protein]
KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]		 CTD PMID:39197814 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Snca synuclein alpha multiple interactions
increases degradation		 EXP Roflumilast inhibits the reaction [Rotenone results in increased expression of SNCA protein]
Roflumilast results in increased degradation of SNCA protein		 CTD PMID:37105514 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]]; KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]]; KT 5720 inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Roflumilast inhibits the reaction [TGFB1 protein results in decreased expression of PPM1A protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased activity of GLB1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CDKN1A protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of CNN1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of FAP protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of PDE4B protein alternative form]; Roflumilast inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]
Roflumilast inhibits the reaction [Hypochlorous Acid results in increased expression of TGFB1 mRNA]		 CTD PMID:39197814 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Roflumilast inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Roflumilast inhibits the reaction [Rotenone results in increased expression of TNF protein]		 CTD PMID:21913898 PMID:33757793 PMID:36706892 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
SCH-351591 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amy1 amylase alpha 1 increases expression EXP SCH 351591 results in increased expression of AMY1A mRNA CTD PMID:20585143 NCBI chr 2:201,382,678...201,397,487
Ensembl chr 2:201,382,675...201,397,816 		JBrowse link
G Ctrl chymotrypsin-like increases expression EXP SCH 351591 results in increased expression of CTRL mRNA CTD PMID:20585143 NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP SCH 351591 results in increased expression of CXCL1 protein CTD PMID:20585143 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP SCH 351591 results in increased expression of DBP mRNA CTD PMID:20585143 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression EXP SCH 351591 results in increased expression of NR1D1 mRNA CTD PMID:20585143 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP SCH 351591 results in increased expression of NR1D2 mRNA CTD PMID:20585143 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553 		JBrowse link
G Per1 period circadian regulator 1 increases expression EXP SCH 351591 results in increased expression of PER1 mRNA CTD PMID:20585143 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431 		JBrowse link
G Prss1 serine protease 1 increases expression EXP SCH 351591 results in increased expression of PRSS1 mRNA CTD PMID:20585143 NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        biochemical role 19574
          enzyme inhibitor 18775
            EC 3.* (hydrolase) inhibitor 18379
              EC 3.1.* (ester hydrolase) inhibitor 14826
                EC 3.1.4.* (phosphoric diester hydrolase) inhibitor 4327
                  EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor 72
                    BRL-50481 0
                    phosphodiesterase IV inhibitor + 72
paths to the root