nasal decongestant - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	nasal decongestant	go back to main search page
Accession:	CHEBI:77715	browse the term
Definition:	A drug used to relieve nasal congestion in the upper respiratory tract.
Synonyms:	related_synonym:	decongestant; decongestants; nasal decongestants
	xref:	Wikipedia:Decongestant

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Rat (578 ) Mouse (574 ) Human (575 ) Chinchilla (0 ) Bonobo (0 ) Dog (3 ) Squirrel (0 ) Pig (3 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (578)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions
increases expression

ISO
EXP

Ephedrine inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Ephedrine inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]
Ephedrine results in increased expression of ACTA2 protein

PMID:32729338 PMID:37778983

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

apolipoprotein A1

multiple interactions

ISO

[Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729

G

apolipoprotein A2

multiple interactions

ISO

[Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein

NCBI chr13:86,176,767...86,178,819
Ensembl chr13:86,174,741...86,179,410

G

apolipoprotein B

multiple interactions

ISO

[Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814

G

apolipoprotein C1

multiple interactions

ISO

[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein

NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:88,474,663...88,478,155

G

apolipoprotein C2

multiple interactions

ISO

[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein

NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:88,457,396...88,463,438

G

apolipoprotein C3

multiple interactions

ISO

[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein

NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679

G

BCL2 associated X, apoptosis regulator

increases expression

EXP

Ephedrine results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

EXP

Ephedrine results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions
increases activity

EXP

[Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 protein
Ephedrine results in increased activity of CASP3 protein

PMID:15537744 PMID:32729338

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

increases activity

EXP

Ephedrine results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

cadherin 1

multiple interactions

ISO

Ephedrine inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; Ephedrine inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

complement factor D

multiple interactions

ISO

[Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD mRNA]; [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD protein]

NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:10,463,775...10,465,572

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

Ephedrine results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

glutamic--pyruvic transaminase

increases expression

EXP

Ephedrine results in increased expression of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

H2A.X variant histone

multiple interactions

EXP

[Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

interleukin 1 beta

increases expression

EXP

Ephedrine results in increased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions
increases expression

ISO
EXP

Ephedrine inhibits the reaction [Bleomycin results in increased secretion of IL6 protein]
Ephedrine results in increased expression of IL6 protein

PMID:32729338 PMID:37778983

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Kelch-like ECH-associated protein 1

multiple interactions

ISO

Ephedrine inhibits the reaction [Bleomycin results in increased expression of KEAP1 protein]

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

keratin 8

multiple interactions

ISO

Ephedrine inhibits the reaction [Bleomycin results in decreased expression of KRT8 mRNA]; Ephedrine inhibits the reaction [Bleomycin results in decreased expression of KRT8 protein]

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

Ephedrine inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NADPH oxidase 1

increases expression

EXP

Ephedrine results in increased expression of NOX1 protein

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:101,572,340...101,595,520

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

Ephedrine inhibits the reaction [Bleomycin results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

SMAD family member 3

increases expression

EXP

Ephedrine results in increased expression of SMAD3 mRNA; Ephedrine results in increased expression of SMAD3 protein

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

SMAD family member 7

decreases expression

EXP

Ephedrine results in decreased expression of SMAD7 protein

NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849

G

transforming growth factor, beta 1

increases expression

EXP

Ephedrine results in increased expression of TGFB1 mRNA; Ephedrine results in increased expression of TGFB1 protein

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions
increases expression

ISO
EXP

Ephedrine inhibits the reaction [Bleomycin results in increased secretion of TNF protein]
Ephedrine results in increased expression of TNF protein

PMID:32729338 PMID:37778983

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

vimentin

multiple interactions

ISO

Ephedrine inhibits the reaction [Bleomycin results in increased expression of VIM mRNA]; Ephedrine inhibits the reaction [Bleomycin results in increased expression of VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

multiple interactions
affects binding

ISO
EXP

[Oxymetazoline binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; Oxymetazoline binds to and results in increased activity of ADRA1A protein; Oxymetazoline inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [Prazosin binds to ADRA1A protein]
Oxymetazoline binds to ADRA1A protein

PMID:8196478 PMID:15872040 PMID:20030735 PMID:21544540

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

adrenoceptor alpha 1B

multiple interactions
affects binding

ISO

Oxymetazoline inhibits the reaction [ADRA1B protein binds to Prazosin]
Oxymetazoline binds to ADRA1B protein

NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,756,461...28,814,347

G

adrenoceptor alpha 1D

multiple interactions
affects binding

ISO

Oxymetazoline inhibits the reaction [ADRA1D protein binds to Prazosin]
Oxymetazoline binds to ADRA1D protein

PMID:15493479 PMID:20030735

NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:139,246,323...139,262,331

G

adrenoceptor alpha 2A

multiple interactions
affects binding

ISO

Oxymetazoline inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]
Oxymetazoline binds to ADRA2A protein

NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871

G

adrenoceptor alpha 2B

multiple interactions

ISO

[Oxymetazoline binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; Oxymetazoline binds to and results in increased activity of ADRA2B protein; Oxymetazoline inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan]

NCBI chr 3:135,038,481...135,042,527
Ensembl chr 3:135,038,474...135,042,525

G

adrenoceptor alpha 2C

affects binding
multiple interactions

ISO

Oxymetazoline binds to ADRA2C protein
Oxymetazoline inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]

NCBI chr14:75,470,884...75,472,846
Ensembl chr14:79,694,995...79,706,656

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

ISO

[CYP2C19 protein co-treated with NADP] results in increased metabolism of Oxymetazoline

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

solute carrier family 22 member 2

multiple interactions

ISO

Oxymetazoline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 9

decreases expression

EXP

Phenylephrine results in decreased expression of ABCC9 mRNA

NCBI chr 4:177,262,848...177,386,837
Ensembl chr 4:177,262,848...177,386,348

G

abhydrolase domain containing 2, acylglycerol lipase

increases expression

EXP

Phenylephrine results in increased expression of ABHD2 mRNA

NCBI chr 1:142,626,748...142,707,892
Ensembl chr 1:142,626,732...142,712,674

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions
increases phosphorylation
affects response to substance

EXP

ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]
Phenylephrine results in increased phosphorylation of ABL1 protein
ABL1 protein affects the susceptibility to Phenylephrine

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846

G

ankyrin repeat and BTB domain containing 3

decreases expression

EXP

Phenylephrine results in decreased expression of ABTB3 mRNA

NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:19,923,814...20,198,110

G

acyl-CoA dehydrogenase medium chain

multiple interactions
decreases expression

EXP

AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of ACADM mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of ACADM mRNA]

NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864

G

acetyl-CoA acetyltransferase 2

increases expression

EXP

Phenylephrine results in increased expression of ACAT2 mRNA

NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095

G

angiotensin I converting enzyme

affects response to substance

ISO

ACE protein affects the susceptibility to Phenylephrine

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

acyl-CoA thioesterase 2

increases expression

EXP

Phenylephrine results in increased expression of ACOT2 mRNA

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502

G

actin, alpha 1, skeletal muscle

multiple interactions
increases expression

ISO
EXP

[Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]

PMID:10642269 PMID:10710348 PMID:11230109 PMID:11499749 PMID:11513749 More...

NCBI chr19:68,781,168...68,784,194
Ensembl chr19:68,781,168...68,786,178

G

actin alpha 2, smooth muscle

multiple interactions
increases expression

EXP

MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA]

PMID:16556869 PMID:18158353

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

actin related protein 3

increases expression

EXP

Phenylephrine results in increased expression of ACTR3 mRNA

NCBI chr13:39,353,413...39,396,509
Ensembl chr13:39,353,079...39,396,711

G

ADAM metallopeptidase domain 17

multiple interactions

EXP

ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]

NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344

G

adenylate cyclase 5

increases response to substance

ISO

ADCY5 protein results in increased susceptibility to Phenylephrine

NCBI chr11:78,976,861...79,123,343
Ensembl chr11:78,976,861...79,123,343

G

alcohol dehydrogenase, iron containing, 1

decreases expression

EXP

Phenylephrine results in decreased expression of ADHFE1 mRNA

NCBI chr 5:14,488,784...14,515,405
Ensembl chr 5:14,488,788...14,515,835

G

adrenomedullin

multiple interactions
decreases response to substance
decreases expression
decreases secretion
increases expression

EXP
ISO

[Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
ADM protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in decreased expression of ADM mRNA
Phenylephrine results in decreased secretion of ADM protein
Phenylephrine results in increased expression of ADM mRNA; Phenylephrine results in increased expression of ADM protein

PMID:11470465 PMID:15370692 PMID:17250927

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:174,178,773...174,182,371

G

adenosine A1 receptor

multiple interactions
increases expression

EXP

1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]
Phenylephrine results in increased expression of ADORA1 mRNA; Phenylephrine results in increased expression of ADORA1 protein

NCBI chr13:48,210,922...48,247,826
Ensembl chr13:48,213,273...48,247,190

G

adenosine A2a receptor

multiple interactions
increases expression

EXP

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]
Phenylephrine results in increased expression of ADORA2A mRNA; Phenylephrine results in increased expression of ADORA2A protein

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,270...13,332,802

G

adenosine A3 receptor

multiple interactions
increases expression

EXP

2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
Phenylephrine results in increased expression of ADORA3 mRNA; Phenylephrine results in increased expression of ADORA3 protein

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:196,077,042...196,080,686

G

ADP-ribosylhydrolase like 1

increases expression

EXP

Phenylephrine results in increased expression of ADPRHL1 mRNA

NCBI chr16:82,985,355...83,017,240

G

adrenoceptor alpha 1A

multiple interactions
affects response to substance
affects binding
increases response to substance
affects activity
increases activity

ISO
EXP

5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]; [KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the abundance of Phosphatidylinositol 4,5-Diphosphate; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Phenylephrine binds to and results in increased activity of ADRA1A protein; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]; Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Ro 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]
ADRA1A protein affects the susceptibility to Phenylephrine
Phenylephrine binds to ADRA1A protein
ADRA1A protein results in increased susceptibility to Phenylephrine
Phenylephrine affects the activity of ADRA1A protein
8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; [Phenylephrine affects the activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased transport of Glucose; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; GR 127935 promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Granisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Phenylephrine binds to and results in increased activity of ADRA1A protein

PMID:8183249 PMID:11709419 PMID:12935885 PMID:15306222 PMID:15365637 More...

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

adrenoceptor alpha 1B

affects response to substance
increases response to substance
multiple interactions
decreases expression
increases activity

ISO
EXP

ADRA1B protein affects the susceptibility to Phenylephrine
ADRA1B protein results in increased susceptibility to Phenylephrine
[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein; [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein
4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; chlorethylclonidine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; Estradiol promotes the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]
Phenylephrine results in decreased expression of ADRA1B mRNA; Phenylephrine results in decreased expression of ADRA1B protein
Phenylephrine results in increased activity of ADRA1B protein
[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]

PMID:10801782 PMID:11499749 PMID:11693201 PMID:15306222 PMID:16498073 More...

NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,756,461...28,814,347

G

adrenoceptor alpha 1D

affects response to substance
increases activity
affects binding
multiple interactions
increases response to substance

ISO
EXP

ADRA1D protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased activity of ADRA1D protein
Phenylephrine binds to ADRA1D protein
[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]
BMY 7378 inhibits the reaction [ADRA1D protein results in increased susceptibility to Phenylephrine]; Phenylephrine binds to and results in increased activity of ADRA1D protein
ADRA1D affects the susceptibility to Phenylephrine

PMID:8183249 PMID:11901185 PMID:15306222 PMID:15493479 PMID:16371063 More...

NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:139,246,323...139,262,331

G

adrenoceptor alpha 2A

multiple interactions

ISO

Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]; Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]]

NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871

G

adrenoceptor alpha 2B

affects response to substance
multiple interactions

ISO

ADRA2B protein affects the susceptibility to Phenylephrine
ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]

NCBI chr 3:135,038,481...135,042,527
Ensembl chr 3:135,038,474...135,042,525

G

adrenoceptor beta 2

multiple interactions

EXP

[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; CGP 20712A inhibits the reaction [[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

adrenoceptor beta 3

multiple interactions
increases response to substance

ISO

amibegron inhibits the reaction [ADRB3 protein results in increased susceptibility to Phenylephrine]

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:71,542,567...71,547,420

G

angiotensinogen

affects response to substance
increases response to substance
multiple interactions
increases expression

EXP
ISO

AGT protein affects the susceptibility to Phenylephrine
AGT protein modified form results in increased susceptibility to Phenylephrine
AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]; carvedilol inhibits the reaction [AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]]; carvedilol inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]; irbesartan inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
Phenylephrine results in increased expression of AGT mRNA; Phenylephrine results in increased expression of AGT protein
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]

PMID:2298476 PMID:7900855 PMID:16251426 PMID:16794485 PMID:27094369

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 2

multiple interactions
affects response to substance

EXP
ISO

[CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine
AGTR2 protein affects the susceptibility to Phenylephrine

PMID:11714657 PMID:19151255

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745

G

apoptosis inducing factor, mitochondria associated 1

increases expression

ISO

Phenylephrine results in increased expression of AIFM1 protein

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

adenylate kinase 4

increases expression

EXP

Phenylephrine results in increased expression of AK4 mRNA

NCBI chr 5:121,154,565...121,214,403
Ensembl chr 5:121,154,572...121,214,401

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation
affects phosphorylation

ISO
EXP

Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
Phenylephrine affects the phosphorylation of AKT1 protein

PMID:10679475 PMID:18084315 PMID:28759639

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

aldehyde dehydrogenase 18 family, member A1

increases expression

EXP

Phenylephrine results in increased expression of ALDH18A1 mRNA

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:249,325,082...249,357,383

G

angiopoietin 1

multiple interactions
increases expression

ISO

ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
Phenylephrine results in increased expression of ANGPT1 mRNA; Phenylephrine results in increased expression of ANGPT1 protein

NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696

G

angiopoietin-like 4

decreases expression

EXP

Phenylephrine results in decreased expression of ANGPTL4 mRNA

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

apolipoprotein E

affects response to substance

ISO

APOE protein affects the susceptibility to Phenylephrine

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

amphiregulin

increases expression

EXP

Phenylephrine results in increased expression of AREG mRNA

NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641

G

Rho guanine nucleotide exchange factor 12

decreases expression

EXP

Phenylephrine results in decreased expression of ARHGEF12 mRNA

NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:52,247,047...52,372,376

G

arrestin domain containing 3

decreases expression

EXP

Phenylephrine results in decreased expression of ARRDC3 mRNA

NCBI chr 2:12,873,202...12,885,716
Ensembl chr 2:12,873,202...12,885,875

G

ankyrin repeat and SOCS box-containing 18

decreases expression

EXP

Phenylephrine results in decreased expression of ASB18 mRNA

NCBI chr 9:90,531,350...90,595,953
Ensembl chr 9:97,979,264...98,043,540

G

ankyrin repeat and SOCS box-containing 4

increases expression

EXP

Phenylephrine results in increased expression of ASB4 mRNA

NCBI chr 4:34,473,527...34,511,163
Ensembl chr 4:34,473,408...34,512,888

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

EXP

Phenylephrine results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

activating transcription factor 5

increases expression

EXP

Phenylephrine results in increased expression of ATF5 mRNA

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

EXP

Phenylephrine results in increased expression of ATP1B1 mRNA

NCBI chr13:79,319,708...79,340,226
Ensembl chr13:79,319,706...79,340,549

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions
decreases expression
affects response to substance
increases expression
decreases activity

ISO
EXP

[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein
Phenylephrine results in decreased expression of ATP2A2 mRNA; Phenylephrine results in decreased expression of ATP2A2 protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of ATP2A2 protein]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in decreased expression of ATP2A2 protein] which results in decreased transport of Calcium; Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]
ATP2A2 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of ATP2A2 mRNA
Phenylephrine results in decreased activity of ATP2A2 protein

PMID:11499749 PMID:11577024 PMID:15795322 PMID:16236312 PMID:17287366 More...

NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934

G

ATPase plasma membrane Ca2+ transporting 4

increases response to substance

ISO

ATP2B4 protein results in increased susceptibility to Phenylephrine

NCBI chr13:47,708,157...47,807,389
Ensembl chr13:47,711,121...47,758,876

G

ATPase phospholipid transporting 9A (putative)

increases expression

EXP

Phenylephrine results in increased expression of ATP9A mRNA

NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:177,779,203...178,023,661

G

ataxin 1

multiple interactions

EXP

Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to ATXN1 protein]]

NCBI chr17:18,943,397...19,354,751
Ensembl chr17:19,208,200...19,356,790

G

activator of transcription and developmental regulator AUTS2

decreases expression

EXP

Phenylephrine results in decreased expression of AUTS2 mRNA

NCBI chr12:24,104,187...25,194,123
Ensembl chr12:29,740,523...30,830,386

G

arginine vasopressin

multiple interactions
increases secretion

EXP

Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of AVP protein]; bisindolylmaleimide I inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; Dexamethasone inhibits the reaction [Phenylephrine results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]

PMID:2271928 PMID:11102496

NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522

G

arginine vasopressin-induced 1

increases expression

EXP

Phenylephrine results in increased expression of AVPI1 mRNA

NCBI chr 1:240,930,236...240,936,154
Ensembl chr 1:250,879,530...250,885,704

G

BCL2-associated agonist of cell death

increases expression

ISO

Phenylephrine results in increased expression of BAD protein

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BMP and activin membrane-bound inhibitor

increases expression

EXP

Phenylephrine results in increased expression of BAMBI mRNA

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:58,816,442...58,821,247

G

BCL2 associated X, apoptosis regulator

decreases expression
increases expression
multiple interactions

EXP
ISO

Phenylephrine results in decreased expression of BAX protein
Phenylephrine results in increased expression of BAX protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]

PMID:19910689 PMID:31605733

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCAR1 scaffold protein, Cas family member

multiple interactions
increases phosphorylation

EXP

ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]

NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190

G

branched chain keto acid dehydrogenase E1 subunit alpha

decreases expression

EXP

Phenylephrine results in decreased expression of BCKDHA mRNA

NCBI chr 1:90,266,731...90,295,521
Ensembl chr 1:90,261,629...90,295,749

G

BCL2, apoptosis regulator

multiple interactions
decreases expression
increases expression

EXP
ISO

BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; Phenylephrine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]
Phenylephrine results in decreased expression of BCL2 protein
Phenylephrine results in increased expression of BCL2 mRNA; Phenylephrine results in increased expression of BCL2 protein

PMID:11042672 PMID:19910689 PMID:31605733 PMID:35979984

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions
decreases expression

EXP
ISO

Phenylephrine inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 mRNA]; Phenylephrine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2L1 protein]
Phenylephrine results in decreased expression of BCL2L1 protein

PMID:11042672 PMID:31605733 PMID:35979984

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

3-hydroxybutyrate dehydrogenase 1

increases expression

EXP

Phenylephrine results in increased expression of BDH1 mRNA

NCBI chr11:82,806,125...82,848,133
Ensembl chr11:82,807,503...82,842,636

G

3-hydroxybutyrate dehydrogenase 2

decreases expression

EXP

Phenylephrine results in decreased expression of BDH2 mRNA

NCBI chr 2:226,376,346...226,397,010
Ensembl chr 2:226,376,356...226,397,006

G

bradykinin receptor B2

affects response to substance
increases expression

ISO
EXP

BDKRB2 affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of BDKRB2 mRNA

PMID:10614985 PMID:18158353

NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209

G

brain-derived neurotrophic factor

increases expression

EXP

Phenylephrine results in increased expression of BDNF mRNA

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

bone morphogenetic protein 2

increases expression

EXP

phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes

RGD

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760

G

bone morphogenetic protein 4

increases expression

EXP

phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes

RGD

NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172

G

bone morphogenetic protein 7

decreases expression
increases expression

EXP

Phenylephrine results in decreased expression of BMP7 mRNA
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes

CTD
RGD

PMID:18158353 PMID:26873969

NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:182,052,337...182,135,137

G

BCL2 interacting protein 3 like

increases expression

EXP

Phenylephrine results in increased expression of BNIP3L mRNA

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

boule homolog, RNA binding protein

decreases expression

EXP

Phenylephrine results in decreased expression of BOLL mRNA

NCBI chr 9:56,734,890...56,859,917
Ensembl chr 9:64,228,472...64,354,319

G

bromodomain containing 4

multiple interactions
increases expression

EXP

Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]
Phenylephrine results in increased expression of BRD4 protein

NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,866,997...11,946,923

G

BTG anti-proliferation factor 3

increases expression

EXP

Phenylephrine results in increased expression of BTG3 mRNA

NCBI chr11:30,517,068...30,532,981
Ensembl chr11:30,517,072...30,533,082

G

carbonic anhydrase 1

decreases activity

ISO

Phenylephrine results in decreased activity of CA1 protein

NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454

G

carbonic anhydrase 4

increases expression

EXP

Phenylephrine results in increased expression of CA4 protein

NCBI chr10:70,325,102...70,333,916
Ensembl chr10:70,325,358...70,333,916

G

calcineurin binding protein 1

multiple interactions

EXP

CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein]

PMID:10655507 PMID:17060317

NCBI chr20:12,892,750...13,014,801
Ensembl chr20:12,892,771...13,014,800

G

calcium dependent secretion activator

decreases expression

EXP

Phenylephrine results in decreased expression of CADPS mRNA

NCBI chr15:14,719,078...15,173,218
Ensembl chr15:14,720,726...15,173,211

G

calcitonin-related polypeptide alpha

affects response to substance

ISO
EXP

CALCA protein affects the susceptibility to Phenylephrine

PMID:11728430 PMID:18055875

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

calcitonin receptor like receptor

multiple interactions

EXP

[Phenylephrine co-treated with Isoproterenol] results in increased expression of CALCRL mRNA

NCBI chr 3:89,835,071...89,932,616
Ensembl chr 3:89,835,077...89,887,350

G

calcium/calmodulin-dependent protein kinase II alpha

decreases expression

EXP

Phenylephrine results in decreased expression of CAMK2A mRNA

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504

G

calcium/calmodulin-dependent protein kinase II delta

multiple interactions

EXP

CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein]

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276

G

carbonic anhydrase 2

increases expression
decreases activity

EXP
ISO

Phenylephrine results in increased expression of CAR2 mRNA; Phenylephrine results in increased expression of CAR2 protein
Phenylephrine results in decreased activity of CA2 protein

PMID:17124262 PMID:28800181

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

caspase 2

affects activity

ISO

Phenylephrine affects the activity of CASP2 protein

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

multiple interactions
increases activity

EXP
ISO

Phenylephrine inhibits the reaction [Oxygen deficiency results in increased activity of CASP3 protein]
Phenylephrine results in increased activity of CASP3 protein

PMID:11042672 PMID:31605733

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

affects activity

ISO

Phenylephrine affects the activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases activity

ISO

Phenylephrine results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

calcium-sensing receptor

multiple interactions

EXP

Phenylephrine inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]

NCBI chr11:77,738,398...77,813,639
Ensembl chr11:77,740,614...77,810,167

G

catalase

multiple interactions
decreases expression

EXP

CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in decreased expression of CAT protein

PMID:16513848 PMID:18171680 PMID:20886221

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

caveolin 1

multiple interactions

ISO

Sodium, Dietary affects the reaction [CAV1 protein results in increased susceptibility to Phenylephrine]

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740

G

caveolin 3

multiple interactions
increases expression
decreases response to substance
affects localization

ISO
EXP

CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of CAV3 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of CAV3 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased expression of CAV3 mRNA]; Cyclosporine inhibits the reaction [Phenylephrine results in increased expression of CAV3 protein]; KN 62 inhibits the reaction [Phenylephrine results in increased expression of CAV3 mRNA]; KN 62 inhibits the reaction [Phenylephrine results in increased expression of CAV3 protein]
Phenylephrine results in increased expression of CAV3 mRNA; Phenylephrine results in increased expression of CAV3 protein
CAV3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine affects the localization of CAV3 protein

PMID:12847114 PMID:15725944 PMID:19299911

NCBI chr 4:147,137,993...147,153,967
Ensembl chr 4:147,137,797...147,153,967

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

EXP

4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]
Phenylephrine results in increased expression of CCL2 mRNA; Phenylephrine results in increased expression of CCL2 protein

PMID:15721863 PMID:15728586

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 27

increases expression

EXP

Phenylephrine results in increased expression of CCL27 mRNA

NCBI chr 5:61,737,261...61,744,375
Ensembl chr 5:61,737,261...61,743,522

G

cellular communication network factor 1

multiple interactions
increases expression

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; calphostin C inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of CCN1 mRNA]
Phenylephrine results in increased expression of CCN1 mRNA; Phenylephrine results in increased expression of CCN1 protein

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

cellular communication network factor 2

increases expression

EXP

Phenylephrine results in increased expression of CCN2 mRNA; Phenylephrine results in increased expression of CCN2 protein

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cyclin D1

multiple interactions
increases expression

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND1 protein]

PMID:12163013 PMID:15603588

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D2

increases expression

EXP

Phenylephrine results in increased expression of CCND2 protein

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

cyclin D3

multiple interactions
increases expression

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CCND3 protein]

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin T1

multiple interactions

EXP

Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein]

NCBI chr 7:131,566,176...131,596,988
Ensembl chr 7:131,566,176...131,596,938

G

Cd200 molecule

decreases expression

EXP

Phenylephrine results in decreased expression of CD200 mRNA

NCBI chr11:55,410,166...55,437,527
Ensembl chr11:68,916,224...68,943,569

G

cadherin 2

increases expression

EXP

Phenylephrine results in increased expression of CDH2 protein

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cyclin dependent kinase 2

increases expression

EXP

Phenylephrine results in increased expression of CDK2 protein

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

increases expression

EXP

Phenylephrine results in increased expression of CDK4 protein

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase inhibitor 1A

increases expression
increases stability

ISO
EXP

Phenylephrine results in increased expression of CDKN1A mRNA; Phenylephrine results in increased expression of CDKN1A protein
Phenylephrine results in increased stability of CDKN1A mRNA

PMID:10766810 PMID:15603588

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

EXP

Phenylephrine results in increased expression of CDKN1B

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

CCAAT/enhancer binding protein alpha

decreases expression

EXP

Phenylephrine results in decreased expression of CEBPA mRNA

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

CF transmembrane conductance regulator

multiple interactions

EXP

[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein; [Phenylephrine co-treated with 6-hydroxy-10-chlorobenzo(c)quinolizinium] results in increased activity of CFTR protein; Glyburide inhibits the reaction [[Phenylephrine co-treated with 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride] results in increased activity of CFTR protein]

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

coiled-coil-helix-coiled-coil-helix domain containing 6

increases expression

EXP

Phenylephrine results in increased expression of CHCHD6 mRNA

NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:123,349,187...123,581,421

G

chloride intracellular channel 2

decreases expression

EXP

Phenylephrine results in decreased expression of CLIC2 mRNA

NCBI chr20:154,630...169,655
Ensembl chr20:154,255...169,648

G

chloride intracellular channel 4

increases expression

EXP

Phenylephrine results in increased expression of CLIC4 mRNA

NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118

G

clusterin

increases expression

EXP

Phenylephrine results in increased expression of CLU mRNA; Phenylephrine results in increased expression of CLU protein

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

calponin 1

increases expression

EXP

Phenylephrine results in increased expression of CNN1 mRNA

NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:28,908,330...28,919,482

G

collagen type XVIII alpha 1 chain

decreases expression

EXP

Phenylephrine results in decreased expression of COL18A1 mRNA

NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,473,645...11,582,112

G

collectin sub-family member 12

decreases expression

EXP

Phenylephrine results in decreased expression of COLEC12 mRNA

NCBI chr18:732,950...920,620
Ensembl chr18:1,005,741...1,195,297

G

corin, serine peptidase

increases expression

EXP

Phenylephrine results in increased expression of CORIN mRNA

NCBI chr14:35,680,601...35,910,703
Ensembl chr14:36,034,993...36,264,649

G

cytochrome c oxidase copper chaperone COX11

decreases expression
multiple interactions

EXP

Phenylephrine results in decreased expression of COX11 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]

PMID:23818984 PMID:25107896

NCBI chr10:75,955,825...75,962,398
Ensembl chr10:75,955,783...75,963,489

G

cytochrome c oxidase copper chaperone COX17

multiple interactions
decreases expression

EXP

Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]

PMID:23818984 PMID:25107896

NCBI chr11:75,906,245...75,912,036
Ensembl chr11:75,906,248...75,912,019

G

cytochrome c oxidase subunit 4i1

decreases expression
multiple interactions

EXP

Phenylephrine results in decreased expression of COX4I1 protein
Copper Sulfate inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]; periodate-oxidized adenosine inhibits the reaction [Phenylephrine results in decreased expression of COX4I1 protein]

NCBI chr19:65,630,383...65,636,623
Ensembl chr19:65,630,432...65,636,624

G

carnitine palmitoyltransferase 1B

multiple interactions
decreases expression
increases expression

EXP

4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of CPT1B protein]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of CPT1B protein]
Phenylephrine results in decreased expression of CPT1B mRNA; Phenylephrine results in decreased expression of CPT1B protein
Phenylephrine results in increased expression of CPT1B mRNA

PMID:11879187 PMID:15721863 PMID:19699196

NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:122,370,444...122,380,036

G

cAMP responsive element binding protein 1

multiple interactions

EXP

adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Propranolol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]

PMID:14741741 PMID:15522277

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

CREB binding protein

multiple interactions
increases response to substance

EXP

[Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine promotes the reaction [CREB1 protein binds to CREBBP protein]; Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of CREBBP protein; Phenylephrine results in increased phosphorylation of and results in increased activity of CREBBP protein
CREBBP protein results in increased susceptibility to Phenylephrine

PMID:11705990 PMID:12477714 PMID:15006641 PMID:15522277 PMID:19966502

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

cAMP responsive element modulator

increases expression

EXP

Phenylephrine results in increased expression of CREM mRNA

PMID:12791704 PMID:18158353

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

CRK proto-oncogene, adaptor protein

multiple interactions

EXP

ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]

NCBI chr10:60,530,469...60,556,703
Ensembl chr10:61,028,757...61,082,988

G

casein kinase 2 alpha 1

decreases expression

EXP

Phenylephrine results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698

G

chondroitin sulfate proteoglycan 4

increases expression

EXP

Phenylephrine results in increased expression of CSPG4 mRNA

NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:66,160,942...66,200,806

G

cysteine and glycine-rich protein 2

increases expression

EXP

Phenylephrine results in increased expression of CSRP2 mRNA

NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:48,235,383...48,266,238

G

cysteine and glycine rich protein 3

increases localization

EXP

Phenylephrine results in increased localization of CSRP3 protein

NCBI chr 1:107,664,338...107,682,916
Ensembl chr 1:107,664,338...107,682,916

G

cystathionine gamma-lyase

increases activity

EXP

Phenylephrine results in increased activity of CTH protein

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066

G

catenin beta 1

multiple interactions

EXP

Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin C

decreases expression

EXP

Phenylephrine results in decreased expression of CTSC mRNA

NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:151,441,032...151,474,082

G

C-X-C motif chemokine ligand 1

decreases expression

EXP

Phenylephrine results in decreased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

decreases expression

EXP

Phenylephrine results in decreased expression of CXCL10 mRNA

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 11

decreases expression

EXP

Phenylephrine results in decreased expression of CXCL11 mRNA

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,973,720...15,976,567

G

C-X-C motif chemokine ligand 6

decreases expression

EXP

Phenylephrine results in decreased expression of CXCL5 mRNA

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,594,959...17,596,417

G

CXXC finger protein 4

decreases expression

EXP

Phenylephrine results in decreased expression of CXXC4 mRNA

NCBI chr 2:225,329,044...225,363,347

G

cytochrome P450, family 11, subfamily b, polypeptide 3

increases expression

EXP

Phenylephrine results in increased expression of CYP11B2 mRNA

NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:108,689,165...108,694,921

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

EXP

Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 26, subfamily b, polypeptide 1

increases expression

EXP

Phenylephrine results in increased expression of CYP26B1 mRNA

NCBI chr 4:118,599,356...118,616,176
Ensembl chr 4:118,599,356...118,616,176

G

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions
increases response to substance
affects response to substance

EXP

20-hydroxy-5,8,11,14-eicosatetraenoic acid affects the reaction [CYP4A1 protein affects the susceptibility to Phenylephrine]; 20-hydroxy-5,8,11,14-eicosatetraenoic acid inhibits the reaction [DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]]; 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]; DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]

PMID:11124159 PMID:12388396

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231

G

cytochrome P450, family 51

increases expression

EXP

Phenylephrine results in increased expression of CYP51 mRNA

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

death associated protein kinase 1

decreases expression

EXP

Phenylephrine results in decreased expression of DAPK1 mRNA

NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,935,625...4,096,581

G

diacylglycerol kinase epsilon

multiple interactions

ISO

DGKE protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein]

NCBI chr10:73,853,030...73,877,334
Ensembl chr10:74,350,246...74,374,478

G

diacylglycerol kinase zeta

multiple interactions

ISO

DGKZ protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:98,359,804...98,401,951

G

7-dehydrocholesterol reductase

increases expression

EXP

Phenylephrine results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:208,444,434...208,461,382

G

iodothyronine deiodinase 2

increases activity
increases expression

EXP

Phenylephrine results in increased activity of DIO2 protein
Phenylephrine results in increased expression of DIO2 mRNA

NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594

G

dynein, axonemal, heavy chain 12

decreases expression

EXP

Phenylephrine results in decreased expression of DNAH12 mRNA

NCBI chr16:1,932,776...2,099,391
Ensembl chr16:1,944,752...2,099,373

G

DnaJ heat shock protein family (Hsp40) member B5

increases expression

EXP

Phenylephrine results in increased expression of DNAJB5 mRNA

NCBI chr 5:61,972,637...61,981,887
Ensembl chr 5:61,972,706...61,981,860

G

dynamin 1-like

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of DNM1L protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of DNM1L protein]

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

double C2-like domains, gamma

decreases expression

EXP

Phenylephrine results in decreased expression of DOC2G mRNA

NCBI chr 1:201,295,377...201,299,867
Ensembl chr 1:210,725,748...210,730,048

G

dermatopontin

decreases expression

EXP

Phenylephrine results in decreased expression of DPT mRNA

NCBI chr13:77,123,224...77,151,646
Ensembl chr13:79,655,985...79,684,758

G

dual specificity phosphatase 1

increases expression

EXP

Phenylephrine results in increased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 6

multiple interactions

EXP

DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]

NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833

G

E2F transcription factor 3

increases expression

EXP

Phenylephrine results in increased expression of E2F3 protein

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725

G

E2F transcription factor 4

increases expression

EXP

Phenylephrine results in increased expression of E2F4 protein

NCBI chr19:50,084,335...50,091,731
Ensembl chr19:50,084,335...50,091,834

G

E2F transcription factor 5

increases expression

EXP

Phenylephrine results in increased expression of E2F5 protein

NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:88,718,567...88,734,143

G

endothelin converting enzyme 1

increases expression

EXP

Phenylephrine results in increased expression of ECE1 mRNA

NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:155,360,639...155,462,719

G

extracellular matrix protein 1

increases expression

EXP

Phenylephrine results in increased expression of ECM1 mRNA

NCBI chr 2:185,976,439...185,981,656
Ensembl chr 2:185,976,440...185,981,606

G

endothelial differentiation-related factor 1

multiple interactions
increases expression
affects response to substance

EXP

MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]
Phenylephrine results in increased expression of MBF1
MBF1 protein affects the susceptibility to Phenylephrine

NCBI chr 3:28,764,906...28,779,499

G

endothelin 1

multiple interactions
increases response to substance
increases expression

ISO
EXP

EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Polyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EDN1 mRNA; Phenylephrine results in increased expression of EDN1 protein

PMID:10788492 PMID:11739382 PMID:12724418 PMID:15007106 PMID:15220332 More...

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

endothelin receptor type A

multiple interactions

EXP

[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Phenylephrine; phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein]

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284

G

endothelin receptor type B

increases expression

EXP

Phenylephrine results in increased expression of EDNRB protein

NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765

G

epidermal growth factor

multiple interactions

EXP

[EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions
increases phosphorylation

ISO
EXP

Atorvastatin inhibits the reaction [Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein]; Phenylephrine results in increased expression of and results in increased phosphorylation of and results in increased activity of EGFR protein
Phenylephrine results in increased phosphorylation of EGFR protein
[EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]

PMID:14676212 PMID:16760267 PMID:18360054

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

egl-9 family hypoxia-inducible factor 3

increases expression

EXP

Phenylephrine results in increased expression of EGLN3 mRNA

NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:77,385,549...77,411,015

G

early growth response 1

multiple interactions
increases expression

ISO
EXP

EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]
Phenylephrine results in increased expression of EGR1; Phenylephrine results in increased expression of EGR1 mRNA
Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter]

PMID:7905536 PMID:10710348 PMID:10779383 PMID:15621046

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

eukaryotic translation initiation factor 4E

multiple interactions
increases phosphorylation

EXP

CGP 57380 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4E protein]

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
increases phosphorylation

EXP

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]

PMID:12411397 PMID:12720544 PMID:12935885 PMID:15757502

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

ETS transcription factor ELK1

multiple interactions
increases phosphorylation
increases expression

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]
Phenylephrine results in increased phosphorylation of ELK1 protein

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:3,693,293...3,709,249

G

ELOVL fatty acid elongase 5

increases expression

EXP

Phenylephrine results in increased expression of ELOVL5 mRNA

NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:87,671,159...87,737,616

G

enolase 2

increases expression

EXP

Phenylephrine results in increased expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220

G

enolase 3

increases expression

EXP

Phenylephrine results in increased expression of ENO3 mRNA

NCBI chr10:55,868,880...55,876,099
Ensembl chr10:55,866,101...55,874,540

G

E1A binding protein p300

multiple interactions
increases expression
increases response to substance

ISO
EXP

EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of EP300 mRNA; Phenylephrine results in increased expression of EP300 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA]; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; anacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of EP300 protein; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]
EP300 protein results in increased susceptibility to Phenylephrine

PMID:11705990 PMID:12477714 PMID:12724418 PMID:15006641 PMID:15220332 More...

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

endothelial PAS domain protein 1

decreases expression

EXP

Phenylephrine results in decreased expression of EPAS1 mRNA

NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729

G

erythrocyte membrane protein band 4.1 like 4B

increases expression

EXP

Phenylephrine results in increased expression of EPB41L4B mRNA

NCBI chr 5:71,691,706...71,852,583
Ensembl chr 5:76,486,902...76,647,752

G

Eph receptor A4

decreases expression

EXP

Phenylephrine results in decreased expression of EPHA4 mRNA

NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755

G

epoxide hydrolase 2

decreases expression

EXP

Phenylephrine results in decreased expression of EPHX2 mRNA

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160

G

estrogen receptor 1

multiple interactions

ISO

ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Nitroprusside]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine]

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

EYA transcriptional coactivator and phosphatase 2

multiple interactions

EXP

EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]

NCBI chr 3:174,754,772...174,938,035
Ensembl chr 3:174,818,554...174,938,034

G

fatty acid binding protein 4

decreases expression

EXP

Phenylephrine results in decreased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

fatty acid desaturase 3

increases expression

EXP

Phenylephrine results in increased expression of FADS3 mRNA

NCBI chr 1:206,685,667...206,702,538
Ensembl chr 1:216,110,201...216,141,758

G

family with sequence similarity 110, member B

decreases expression

EXP

Phenylephrine results in decreased expression of FAM110B mRNA

NCBI chr 5:18,789,362...18,929,647
Ensembl chr 5:23,586,867...23,799,583

G

fibrillin 1

multiple interactions

ISO

FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Epoprostenol metabolite]; FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Thromboxane A2 metabolite]; FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine]

NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:133,008,361...133,204,283

G

ferredoxin 1

increases expression

EXP

Phenylephrine results in increased expression of FDX1 mRNA

NCBI chr 8:61,164,839...61,183,645
Ensembl chr 8:61,164,839...61,183,583

G

fibroblast growth factor 12

increases expression

EXP

Phenylephrine results in increased expression of FGF12 mRNA

NCBI chr11:85,501,947...86,069,543
Ensembl chr11:85,501,936...86,069,543

G

fibroblast growth factor 18

increases expression

EXP

Phenylephrine results in increased expression of FGF18 mRNA

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:18,210,512...18,240,933

G

fibroblast growth factor 2

multiple interactions

EXP

Phenylephrine promotes the reaction [EGR1 protein binds to FGF2 promoter]

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

four and a half LIM domains 1

increases expression

EXP

Phenylephrine results in increased expression of FHL1 mRNA

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:139,592,604...139,652,282

G

four and a half LIM domains 2

decreases response to substance

EXP

FHL2 gene mutant form results in decreased susceptibility to Phenylephrine

NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:52,880,998...52,923,326

G

fission, mitochondrial 1

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of FIS1 protein
CAT protein inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of FIS1 protein]

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

Fms related receptor tyrosine kinase 1

multiple interactions
increases expression

EXP

FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of FLT1 protein

PMID:19542178 PMID:24903162

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750

G

fibronectin 1

increases expression

ISO

Phenylephrine results in increased expression of FN1 protein

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
affects expression
affects response to substance
increases expression

ISO
EXP

[Phenylephrine co-treated with Isoproterenol] results in increased expression of FOS mRNA; U 0126 inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]
Phenylephrine affects the expression of FOS protein
FOS protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of FOS; Phenylephrine results in increased expression of FOS mRNA; Phenylephrine results in increased expression of FOS protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; [Phenylephrine co-treated with Adenosine Triphosphate] results in increased expression of FOS mRNA; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of FOS mRNA]; Phenylephrine promotes the reaction [ELK1 protein modified form binds to FOS promoter]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]; Troglitazone inhibits the reaction [Phenylephrine results in increased expression of FOS protein]

PMID:7844257 PMID:7900855 PMID:7905536 PMID:8750937 PMID:8809800 More...

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases activity
increases expression

EXP

Phenylephrine results in increased activity of FOSB protein
Phenylephrine results in increased expression of FOSB

PMID:7905536 PMID:15949472

NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477

G

forkhead box O1

multiple interactions

EXP

Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]; Phenylephrine results in increased expression of and results in decreased phosphorylation of and affects the localization of FOXO1 protein

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

follistatin like 3

affects expression

EXP

Phenylephrine affects the expression of FSTL3 mRNA

NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:10,574,186...10,590,509

G

FXYD domain-containing ion transport regulator 5

increases expression

EXP

Phenylephrine results in increased expression of FXYD5 mRNA

NCBI chr 1:95,395,327...95,404,722
Ensembl chr 1:95,395,146...95,405,364

G

polypeptide N-acetylgalactosaminyltransferase 13

decreases expression

EXP

Phenylephrine results in decreased expression of GALNT13 mRNA

NCBI chr 3:59,312,628...59,969,633
Ensembl chr 3:59,383,516...59,965,379

G

guanidinoacetate N-methyltransferase

decreases expression

EXP

Phenylephrine results in decreased expression of GAMT mRNA

NCBI chr 7:10,099,267...10,102,083
Ensembl chr 7:10,098,571...10,102,083

G

GATA binding protein 4

multiple interactions
increases activity
increases expression
increases acetylation
affects response to substance

ISO
EXP

EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA]
Phenylephrine results in increased expression of GATA4 protein
Phenylephrine results in increased acetylation of GATA4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; MAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter]; Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of GATA4 protein; Y 27632 inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]
GATA4 protein affects the susceptibility to Phenylephrine
[Phenylephrine co-treated with Isoproterenol] results in increased expression of GATA4 mRNA

PMID:10710348 PMID:10788492 PMID:11739382 PMID:12724418 PMID:15220332 More...

NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609

G

growth differentiation factor 15

affects expression

ISO

Phenylephrine affects the expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

gamma-glutamyltransferase 1

multiple interactions

ISO

Phenylephrine promotes the reaction [Ethylene Dibromide results in increased activity of GGT1 protein]

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

gap junction protein, alpha 1

multiple interactions
increases expression
affects response to substance

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]
Phenylephrine results in increased expression of GJA1 mRNA; Phenylephrine results in increased expression of GJA1 protein
GJA1 protein affects the susceptibility to Phenylephrine

PMID:16352648 PMID:18445782 PMID:18593691

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

gap junction protein, alpha 5

decreases expression

EXP

Phenylephrine results in decreased expression of GJA5 mRNA

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:187,234,674...187,318,512

G

galactosidase, alpha

affects response to substance

ISO

GLA protein affects the susceptibility to Phenylephrine

NCBI chr X:102,062,497...102,073,915
Ensembl chr X:102,056,718...102,073,915

G

glutaredoxin 3

affects response to substance
increases expression
multiple interactions

EXP

GLRX3 protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased expression of GLRX3 mRNA
GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]

NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:201,671,481...201,701,717

G

glia maturation factor, gamma

increases expression

EXP

Phenylephrine results in increased expression of GMFG mRNA

NCBI chr 1:92,856,154...92,866,722
Ensembl chr 1:92,854,995...92,866,723

G

G protein subunit alpha q

multiple interactions

EXP

RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]

NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:222,852,097...223,126,742

G

GNAS complex locus

affects response to substance

EXP

GNAS protein affects the susceptibility to Phenylephrine

NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536

G

gonadotropin releasing hormone 1

multiple interactions
increases secretion
decreases secretion

EXP

alfuzosin inhibits the reaction [Phenylephrine results in decreased secretion of GNRH1 protein]; alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of GNRH1 protein]; Testosterone affects the reaction [Phenylephrine affects the secretion of GNRH1 protein]

NCBI chr15:46,147,878...46,152,086
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977

G

glycoprotein m6a

decreases expression

EXP

Phenylephrine results in decreased expression of GPM6A mRNA

NCBI chr16:43,374,385...43,706,461
Ensembl chr16:43,374,385...43,706,705

G

G protein-coupled receptor kinase 2

multiple interactions
increases expression

ISO
EXP

[Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein
Phenylephrine results in increased expression of GRK2 protein
GRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]

PMID:11499749 PMID:28759639

NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:211,009,978...211,031,015

G

glycogen synthase kinase 3 beta

multiple interactions
increases phosphorylation

EXP

GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]

PMID:15795328 PMID:28759639

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione S-transferase kappa 1

decreases expression

EXP

Phenylephrine results in decreased expression of GSTK1 mRNA

NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:72,085,531...72,089,927

G

glutathione S-transferase, mu 5

decreases expression

EXP

Phenylephrine results in decreased expression of GSTM3 mRNA

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731

G

glycogen synthase 2

decreases activity

EXP

Phenylephrine results in decreased activity of GYS2 protein

NCBI chr 4:177,096,063...177,137,236
Ensembl chr 4:177,096,063...177,137,236

G

hepcidin antimicrobial peptide

decreases expression

EXP

Phenylephrine results in decreased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

heparin-binding EGF-like growth factor

increases expression

EXP

Phenylephrine results in increased expression of DTR mRNA

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220

G

histone deacetylase 5

multiple interactions

ISO

[Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein

NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,652,656...87,694,244

G

HDGF like 2

decreases expression

EXP

Phenylephrine results in decreased expression of HDGFL2 mRNA

NCBI chr 9:996,687...1,016,352
Ensembl chr 9:996,758...1,016,735

G

HECT and RLD domain containing E3 ubiquitin protein ligase 3

increases expression

EXP

Phenylephrine results in increased expression of HERC3 mRNA

NCBI chr 4:89,282,374...89,372,656
Ensembl chr 4:89,282,445...89,372,652

G

HEXIM P-TEFb complex subunit 1

multiple interactions

EXP

Phenylephrine inhibits the reaction [HEXIM1 protein binds to CCNT1 protein]

NCBI chr10:88,562,889...88,565,001
Ensembl chr10:88,560,519...88,580,000

G

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions
decreases expression
decreases response to substance

ISO

HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
Phenylephrine results in decreased expression of HEY2 mRNA
HEY2 protein results in decreased susceptibility to Phenylephrine

PMID:16603706 PMID:20001863

NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:28,641,057...28,651,187

G

HIG1 hypoxia inducible domain family, member 1A

increases expression

EXP

Phenylephrine results in increased expression of HIGD1A mRNA

NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:130,391,661...130,400,888

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

EXP

Phenylephrine results in increased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

homer scaffold protein 1

increases expression

EXP

Phenylephrine results in increased expression of HOMER1 mRNA alternative form

NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:26,278,105...26,381,657

G

heat shock protein family B (small) member 3

increases expression

EXP

Phenylephrine results in increased expression of HSPB3 mRNA

NCBI chr 2:45,295,285...45,295,999
Ensembl chr 2:47,024,757...47,029,373

G

inhibitor of DNA binding 1

increases expression
increases expression

EXP

Phenylephrine results in increased expression of ID1 mRNA
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes

CTD
RGD

PMID:18158353 PMID:26873969

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685

G

inhibitor of DNA binding 4

increases expression

EXP

Phenylephrine results in increased expression of ID4 mRNA

NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,595,724...16,598,492

G

isopentenyl-diphosphate delta isomerase 1

increases expression

EXP

Phenylephrine results in increased expression of IDI1 mRNA

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

immediate early response 3

decreases response to substance
affects localization

ISO

IER3 protein results in decreased susceptibility to Phenylephrine
Phenylephrine affects the localization of IER3 protein

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

insulin-like growth factor 1

affects response to substance

EXP

IGF1 protein affects the susceptibility to Phenylephrine

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor binding protein 4

affects response to substance

EXP

IGFBP4 protein affects the susceptibility to Phenylephrine

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:84,485,775...84,503,473

G

insulin-like growth factor binding protein 5

decreases expression

EXP

Phenylephrine results in decreased expression of IGFBP5 mRNA

NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:81,897,616...81,914,390

G

interferon gamma induced GTPase

decreases expression

EXP

Phenylephrine results in decreased expression of IGTP mRNA

NCBI chr10:42,374,590...42,382,410
Ensembl chr10:42,876,790...42,882,858

G

inhibitor of nuclear factor kappa B kinase subunit beta

increases activity
multiple interactions

EXP

Phenylephrine results in increased activity of IKBKB protein
IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 1 beta

multiple interactions
decreases response to substance
affects response to substance

EXP

Halothane affects the reaction [IL1B protein affects the susceptibility to Phenylephrine]
IL1B protein results in decreased susceptibility to Phenylephrine

PMID:11506125 PMID:13679239

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

increases expression
multiple interactions
decreases expression

EXP

Phenylephrine results in increased expression of IL6 mRNA
[resveratrol co-treated with Phenylephrine] results in increased expression of IL6 mRNA
Phenylephrine results in decreased expression of IL6 mRNA

PMID:11406463 PMID:12423672 PMID:22748497

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin-linked kinase

multiple interactions
affects localization

ISO
EXP

Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]
Phenylephrine affects the localization of ILK protein
ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:16170337 PMID:18502941

NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964

G

inhibin subunit alpha

increases expression

EXP

Phenylephrine results in increased expression of INHA mRNA

NCBI chr 9:84,443,109...84,446,010
Ensembl chr 9:84,443,109...84,446,009

G

interferon regulatory factor 7

decreases expression

EXP

Phenylephrine results in decreased expression of IRF7 mRNA

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023

G

ISG15 ubiquitin-like modifier

decreases expression

EXP

Phenylephrine results in decreased expression of ISG15 mRNA

NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656

G

integrin subunit alpha 9

increases expression

EXP

Phenylephrine results in increased expression of ITGA9 mRNA

NCBI chr 8:127,185,244...127,493,296
Ensembl chr 8:127,169,226...127,493,296

G

integrin subunit beta 3 binding protein

increases expression

EXP

Phenylephrine results in increased expression of ITGB3BP mRNA

NCBI chr 5:119,575,657...119,640,974
Ensembl chr 5:119,575,248...119,640,997

G

integrin subunit beta 8

increases expression

EXP

Phenylephrine results in increased expression of ITGB8 mRNA

NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:146,165,484...146,351,245

G

inositol 1,4,5-trisphosphate receptor, type 2

increases activity
multiple interactions

ISO

Phenylephrine results in increased activity of ITPR2 protein
[Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA

NCBI chr 4:180,759,325...181,165,361
Ensembl chr 4:180,760,442...181,164,763

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases phosphorylation
increases expression
increases activity
affects response to substance

ISO
EXP

[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]
Phenylephrine results in increased phosphorylation of JUN protein
Phenylephrine results in increased expression of JUN; Phenylephrine results in increased expression of JUN mRNA; Phenylephrine results in increased expression of JUN protein
Phenylephrine results in increased activity of JUN protein
JUN protein affects the susceptibility to Phenylephrine
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased phosphorylation of JUN protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; pyrazolanthrone inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]

PMID:7905536 PMID:10710348 PMID:11799083 PMID:12169099 PMID:12574153 More...

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression
increases activity

EXP

Phenylephrine results in increased expression of JUNB
Phenylephrine results in increased activity of JUNB protein

PMID:7905536 PMID:15949472

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

ISO

JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in decreased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

potassium voltage-gated channel subfamily D member 2

multiple interactions
decreases expression
decreases response to substance

EXP

CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]; CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Phenylephrine results in decreased expression of KCND2 mRNA; Phenylephrine results in decreased expression of KCND2 protein
KCND2 protein results in decreased susceptibility to Phenylephrine

PMID:12403671 PMID:16385079 PMID:17060317

NCBI chr 4:50,741,595...51,243,540
Ensembl chr 4:50,742,839...51,243,522

G

potassium voltage-gated channel subfamily D member 3

multiple interactions
decreases expression

ISO
EXP

[KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form]; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]
Phenylephrine results in decreased expression of KCND3 mRNA; Phenylephrine results in decreased expression of KCND3 protein

PMID:11249870 PMID:11709419 PMID:16385079 PMID:17060317

NCBI chr 2:195,626,316...195,843,690
Ensembl chr 2:195,626,316...195,843,690

G

potassium voltage-gated channel subfamily H member 2

multiple interactions

ISO

Phenylephrine affects the reaction [KCNH2 protein results in increased transport of Potassium]

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium voltage-gated channel interacting protein 2

multiple interactions
decreases expression

EXP

MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]
Phenylephrine results in decreased expression of KCNIP2 mRNA; Phenylephrine results in decreased expression of KCNIP2 mRNA alternative form; Phenylephrine results in decreased expression of KCNIP2 protein

PMID:16385079 PMID:17060317 PMID:18158353

NCBI chr 1:254,590,172...254,614,437
Ensembl chr 1:254,590,175...254,613,898

G

KDEL endoplasmic reticulum protein retention receptor 3

increases expression

EXP

Phenylephrine results in increased expression of KDELR3 mRNA

NCBI chr 7:111,079,236...111,089,463
Ensembl chr 7:112,959,718...112,969,858

G

kinase insert domain receptor

decreases expression
multiple interactions
increases expression

EXP

Phenylephrine results in decreased expression of KDR mRNA
Copper inhibits the reaction [Phenylephrine results in increased expression of KDR protein]

PMID:18158353 PMID:24903162

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

kinesin family member 5B

decreases expression

EXP

Phenylephrine results in decreased expression of KIF5B mRNA

NCBI chr17:56,185,386...56,222,990
Ensembl chr17:56,185,380...56,223,008

G

KLF transcription factor 4

multiple interactions
decreases expression

EXP

Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]
Phenylephrine results in decreased expression of KLF4 mRNA; Phenylephrine results in decreased expression of KLF4 protein

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592

G

kelch-like family member 24

decreases expression

EXP

Phenylephrine results in decreased expression of KLHL24 mRNA

NCBI chr11:94,348,024...94,382,085
Ensembl chr11:94,351,157...94,382,050

G

lysine methyltransferase 2E

decreases expression

EXP

Phenylephrine results in decreased expression of KMT2E mRNA

NCBI chr 4:12,550,570...12,655,329
Ensembl chr 4:12,550,570...12,619,721

G

laminin subunit gamma 1

increases expression

EXP

Phenylephrine results in increased expression of LAMC1 mRNA

NCBI chr13:65,374,372...65,501,492
Ensembl chr13:67,924,872...68,051,986

G

laminin subunit gamma 2

increases expression

EXP

Phenylephrine results in increased expression of LAMC2 mRNA

NCBI chr13:67,835,199...67,894,694
Ensembl chr13:67,835,199...67,895,102

G

low density lipoprotein receptor

increases expression

EXP

Phenylephrine results in increased expression of LDLR mRNA

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

galectin 3 binding protein

decreases expression

EXP

Phenylephrine results in decreased expression of LGALS3BP mRNA

NCBI chr10:104,118,510...104,127,848
Ensembl chr10:104,118,510...104,127,848

G

LIM zinc finger domain containing 1

affects localization

EXP

Phenylephrine affects the localization of LIMS1 protein

NCBI chr20:26,309,833...26,418,511
Ensembl chr20:26,852,996...26,961,606

G

LIM and cysteine-rich domains 1

increases expression

EXP

Phenylephrine results in increased expression of LMCD1 mRNA

NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:146,948,958...147,007,875

G

lipoprotein lipase

affects response to substance

ISO

LPL protein affects the susceptibility to Phenylephrine

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

leucine rich repeat containing 27

decreases expression

EXP

Phenylephrine results in decreased expression of LRRC27 mRNA

NCBI chr 1:194,004,967...194,035,087
Ensembl chr 1:203,434,355...203,464,676

G

LYL1, basic helix-loop-helix family member

increases expression

EXP

Phenylephrine results in increased expression of LYL1 mRNA

NCBI chr19:23,452,140...23,455,007
Ensembl chr19:40,354,819...40,359,834

G

MAF bZIP transcription factor K

increases expression

EXP

Phenylephrine results in increased expression of MAFK mRNA

NCBI chr12:19,948,473...19,970,351
Ensembl chr12:19,948,476...19,959,192

G

mannosidase, alpha, class 1A, member 1

decreases expression

EXP

Phenylephrine results in decreased expression of MAN1A mRNA

NCBI chr20:33,745,158...33,928,584
Ensembl chr20:33,745,165...33,928,584

G

monoamine oxidase A

multiple interactions

ISO

[MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

multiple interactions

ISO

[MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

mitogen activated protein kinase kinase 1

multiple interactions

EXP

MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen-activated protein kinase kinase kinase 1

multiple interactions

EXP

MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions
increases activity

EXP

CAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein]; KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein]

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen activated protein kinase kinase kinase 7

increases phosphorylation
multiple interactions

EXP

phenylephrin increases phosphorylation of Map3k7 protein in neonatal cardiomyocytes
Phenylephrine promotes the reaction [Map3k7 protein binds to Tab1 protein in neonatal cardiomyocytes]
Phenylephrine promotes the reaction [Map3k7 protein binds to Ripk2 protein]
Phenylephrine increases phosphorylation of Map3k7 protein in neonatal cardiomyocytes

RGD

PMID:32971071 PMID:35352799 PMID:34733837 PMID:35490166

RGD:155791643, RGD:155804287, RGD:155791674, RGD:155791668

NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation
increases expression
increases activity
affects phosphorylation

ISO
EXP

[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Phenylephrine results in increased expression of MAPK1 protein modified form
Phenylephrine results in increased activity of MAPK1 protein
Phenylephrine affects the phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; [Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 protein; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; BMY 7378 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; calphostin C inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of MAPK1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Lovastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; MAPK1 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK1 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of EP300 mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of MAPK1 protein; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Pertussis Toxin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]

PMID:10422649 PMID:10660688 PMID:10727428 PMID:10788492 PMID:10888249 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 10

multiple interactions

ISO

MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine]

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100

G

mitogen activated protein kinase 14

increases phosphorylation

EXP

Phenylephrine results in increased phosphorylation of MAPK14 protein

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation
increases expression
increases activity
affects phosphorylation

ISO
EXP

[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; CAV3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in increased expression of MAPK3 protein modified form
Phenylephrine results in increased activity of MAPK3 protein
Phenylephrine affects the phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; [EGF protein binds to EGFR protein] promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 protein; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; BMY 7378 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; calphostin C inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of MAPK3 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; latrunculin B inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MAPK3 protein affects the reaction [Phenylephrine results in increased expression of ELK1 mRNA]; MAPK3 protein affects the reaction [Phenylephrine results in increased phosphorylation of GATA4 protein]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of MAPK3 protein; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Atorvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Pertussis Toxin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]

PMID:10422649 PMID:10660688 PMID:10727428 PMID:10788492 PMID:10888249 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 7

multiple interactions

EXP

Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein]

NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,669,721...46,675,806

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

EXP

GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
Phenylephrine results in increased phosphorylation of MAPK8 protein

PMID:10727428 PMID:16385079 PMID:16517124 PMID:16809552

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 8 interacting protein 1

affects response to substance
multiple interactions

EXP

MAPK8IP1 protein affects the susceptibility to Phenylephrine
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:98,810,541...98,828,368

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation
affects response to substance

ISO
EXP

MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Phenylephrine]
Phenylephrine results in increased phosphorylation of MAPK9 protein

PMID:10727428 PMID:16949803

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

MBL associated serine protease 1

decreases expression

EXP

Phenylephrine results in decreased expression of MASP1 mRNA

NCBI chr11:77,334,794...77,405,271
Ensembl chr11:90,839,061...90,917,470

G

myocyte enhancer factor 2C

multiple interactions
increases expression
increases activity

ISO
EXP

Go 6976 inhibits the reaction [Phenylephrine results in increased activity of MEF2C protein]
Phenylephrine results in increased expression of MEF2C mRNA
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]; KN 62 inhibits the reaction [Phenylephrine results in increased expression of MEF2C mRNA]

PMID:10737771 PMID:19124542

NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:15,708,924...15,871,640

G

microfibril associated protein 4

decreases expression

EXP

Phenylephrine results in decreased expression of MFAP4 mRNA

NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,655,722...46,669,740

G

multifunctional ROCO family signaling regulator 1

decreases expression

EXP

Phenylephrine results in decreased expression of MFHAS1 mRNA

NCBI chr16:56,545,462...56,633,649
Ensembl chr16:63,250,455...63,336,602

G

mitofusin 2

decreases expression
multiple interactions

EXP

Phenylephrine results in decreased expression of MFN2 mRNA; Phenylephrine results in decreased expression of MFN2 protein
CAT protein inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]; Ruthenium Red inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein]

PMID:17499311 PMID:20886221

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

monoglyceride lipase

decreases expression

EXP

Phenylephrine results in decreased expression of MGLL mRNA

NCBI chr 4:122,749,436...122,851,440
Ensembl chr 4:122,749,436...122,851,440

G

microRNA 21

increases expression

EXP

Phenylephrine results in increased expression of MIR21 mRNA

NCBI chr10:71,902,600...71,902,691

G

mixed lineage kinase domain like pseudokinase

increases expression

ISO

Phenylephrine results in increased expression of MLKL protein

NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858

G

MLLT11, transcription factor 7 cofactor

increases expression

EXP

Phenylephrine results in increased expression of MLLT11 mRNA

NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:185,484,793...185,493,961

G

matrix metallopeptidase 2

multiple interactions

ISO
EXP

MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; MMP2 protein affects the susceptibility to [Phenylephrine co-treated with Oxygen deficiency]

PMID:16251426 PMID:16980344

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

increases expression

ISO

Phenylephrine results in increased expression of MMP9 mRNA

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

Mov10 like RNA helicase 1

multiple interactions

ISO
EXP

MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

PMID:11854500 PMID:12754203

NCBI chr 7:120,070,171...120,135,406
Ensembl chr 7:121,949,822...122,015,042

G

methylsterol monooxygenase 1

increases expression

EXP

Phenylephrine results in increased expression of MSMO1 mRNA

NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445

G

moesin

increases expression

EXP

Phenylephrine results in increased expression of MSN mRNA

NCBI chr X:65,005,546...65,073,512
Ensembl chr X:65,005,458...65,075,129

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

increases expression

EXP

Phenylephrine results in increased expression of MTHFD1L mRNA

NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:42,849,374...43,038,309

G

mechanistic target of rapamycin kinase

multiple interactions

EXP

[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

musculoskeletal, embryonic nuclear protein 1

increases expression

EXP

Phenylephrine results in increased expression of MUSTN1 mRNA

NCBI chr16:6,072,908...6,075,161
Ensembl chr16:6,079,277...6,081,586

G

MYB proto-oncogene like 1

increases expression

EXP

Phenylephrine results in increased expression of MYBL1 mRNA

NCBI chr 5:14,365,768...14,401,012
Ensembl chr 5:14,365,768...14,399,588

G

myosin binding protein C3

multiple interactions

ISO

MYBPC3 gene mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]
MYBPC3 mutant form results in increased susceptibility to [Isoproterenol co-treated with Phenylephrine]

NCBI chr 3:97,550,974...97,569,216
Ensembl chr 3:97,551,061...97,569,216

G

myosin heavy chain 14

decreases expression

EXP

Phenylephrine results in decreased expression of MYH14 mRNA

NCBI chr 1:104,232,778...104,295,369
Ensembl chr 1:104,232,778...104,323,404

G

myosin heavy chain 6

multiple interactions
decreases expression

EXP

Prazosin inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]; THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA]

PMID:11577024 PMID:15578571 PMID:15795322 PMID:17592507

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333

G

myosin heavy chain 7

multiple interactions
increases expression

ISO
EXP

CAV3 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]
Phenylephrine results in increased expression of MYH7 mRNA
Phenylephrine results in increased expression of MYH7 mRNA; Phenylephrine results in increased expression of MYH7 protein
anacardic acid inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EP300 protein promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; spiruchostatin A inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; THRB protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
[Phenylephrine co-treated with Isoproterenol] results in increased expression of MYH7 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]

PMID:10642269 PMID:10710348 PMID:11249870 PMID:11513749 PMID:11577024 More...

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194

G

myosin, light chain 1

increases expression

EXP

Phenylephrine results in increased expression of MYL1 mRNA

NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:75,887,227...75,907,971

G

myosin light chain 2

multiple interactions
increases phosphorylation
increases expression

EXP

ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]
Phenylephrine results in increased phosphorylation of MYL2 protein

PMID:11470465 PMID:11513749 PMID:14676212 PMID:15007106 PMID:18202317

NCBI chr12:34,454,223...34,468,554
Ensembl chr12:40,114,958...40,129,149

G

myosin light chain 7

multiple interactions
increases phosphorylation

ISO

ML 7 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]; wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]

NCBI chr14:80,780,684...80,783,259
Ensembl chr14:84,993,736...84,997,372

G

myosin light chain 9

increases phosphorylation

EXP

Phenylephrine results in increased phosphorylation of MYL9 protein

NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:165,742,046...165,748,410

G

myosin light chain kinase 3

increases phosphorylation

ISO

Phenylephrine results in increased phosphorylation of MYLK3 protein

NCBI chr19:37,858,298...37,916,805
Ensembl chr19:37,865,141...37,915,827

G

myocardin

multiple interactions
increases expression

EXP

MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA]; MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]
Phenylephrine results in increased expression of MYOCD mRNA; Phenylephrine results in increased expression of MYOCD protein

PMID:14676212 PMID:16556869

NCBI chr10:50,332,356...50,426,819
Ensembl chr10:50,332,356...50,426,819

G

myozenin 2

multiple interactions
decreases response to substance

ISO

MYOZ2 protein inhibits the reaction [Phenylephrine results in increased expression of RCAN1 protein]
MYOZ2 protein results in decreased susceptibility to Phenylephrine

NCBI chr 2:213,826,052...213,852,778
Ensembl chr 2:213,826,052...213,852,914

G

Ngfi-A binding protein 1

multiple interactions

ISO

[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB1 mRNA

NCBI chr 9:56,545,547...56,585,045
Ensembl chr 9:56,545,729...56,614,210

G

Ngfi-A binding protein 2

multiple interactions

ISO

[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NAB2 mRNA]

NCBI chr 7:65,382,863...65,389,527
Ensembl chr 7:65,382,863...65,389,255

G

neurocalcin delta

increases expression

EXP

Phenylephrine results in increased expression of NCALD mRNA

NCBI chr 7:68,532,671...68,964,740
Ensembl chr 7:70,419,433...70,849,482

G

neutrophil cytosolic factor 1

increases phosphorylation
increases expression

EXP
ISO

Phenylephrine results in increased phosphorylation of NCF1 protein
Phenylephrine results in increased expression of NCF1 mRNA

PMID:14656924 PMID:15936005

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:28,121,366...28,131,079

G

nuclear factor of activated T-cells 1

multiple interactions
affects localization

EXP

Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein]; KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]; Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein; sanggenone C inhibits the reaction [Phenylephrine affects the localization of NFATC1 protein]

PMID:12403671 PMID:19349967 PMID:28849031

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

nuclear factor of activated T-cells 3

increases localization
multiple interactions

ISO

Phenylephrine results in increased localization of NFATC3 protein
[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]

NCBI chr19:50,870,464...50,944,992
Ensembl chr19:50,870,489...50,944,992

G

nuclear factor of activated T-cells 4

multiple interactions
increases localization
affects localization

ISO
EXP

Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]
Phenylephrine affects the localization of NFATC4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine affects the localization of NFATC4 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein]

PMID:11044444 PMID:16055480

NCBI chr15:29,286,998...29,314,610
Ensembl chr15:33,274,153...33,285,582

G

nuclear factor, interleukin 3 regulated

multiple interactions

ISO

U 0126 inhibits the reaction [Phenylephrine results in increased expression of NFIL3 mRNA]

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826

G

NFKB inhibitor alpha

multiple interactions
increases degradation
decreases expression

EXP

4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in decreased expression of NFKBIA protein]; KN 93 inhibits the reaction [Phenylephrine results in increased degradation of NFKBIA protein]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:11381115 PMID:15629441 PMID:16421291

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nidogen 2

increases expression

EXP

Phenylephrine results in increased expression of NID2 mRNA

NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,506,756...4,562,949

G

NK2 homeobox 5

multiple interactions

ISO

[Phenylephrine co-treated with Isoproterenol] results in increased expression of NKX2-5 mRNA

NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,848,582...16,851,452

G

nodal growth differentiation factor

affects expression

EXP

Phenylephrine affects the expression of NODAL mRNA; Phenylephrine affects the expression of NODAL protein

NCBI chr20:29,911,258...29,919,659
Ensembl chr20:29,911,258...29,919,659

G

nucleolar protein 3

decreases phosphorylation

EXP

Phenylephrine results in decreased phosphorylation of NOL3 protein

NCBI chr19:50,066,493...50,068,175
Ensembl chr19:50,063,986...50,068,722

G

nitric oxide synthase 2

multiple interactions
increases activity
decreases response to substance
affects response to substance

ISO
EXP

NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Adenosine Diphosphate]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Calcimycin]; NOS2 protein affects the susceptibility to [Phenylephrine co-treated with Nitroprusside]
Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 protein]
Phenylephrine results in increased activity of NOS2 protein
NOS2 protein results in decreased susceptibility to Phenylephrine
NOS2 protein affects the susceptibility to Phenylephrine

PMID:11498454 PMID:15753950 PMID:15902277

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

affects response to substance
decreases response to substance
multiple interactions
increases expression

ISO
EXP

NOS3 protein affects the susceptibility to Phenylephrine
NOS3 protein results in decreased susceptibility to Phenylephrine
NOS3 protein results in increased susceptibility to [Acetylcholine co-treated with Phenylephrine]
Phenylephrine results in increased expression of NOS3 mRNA; Phenylephrine results in increased expression of NOS3 protein

PMID:10954898 PMID:11504159 PMID:15381055 PMID:15753950 PMID:17403420

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

natriuretic peptide A

increases secretion
increases expression
multiple interactions
decreases response to substance

ISO
EXP

Phenylephrine results in increased secretion of NPPA protein
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes
Phenylephrine results in increased expression of NPPA mRNA; Phenylephrine results in increased expression of NPPA protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; (+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; 4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; 8-(4-sulfophenyl)theophylline inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Oxygen deficiency] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of CREBBP protein] which results in increased expression of NPPA protein; [Phenylephrine results in increased activity of EP300 protein] which results in increased expression of NPPA protein; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Aldosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CABIN1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPA protein]; chelerythrine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; chelerythrine promotes the reaction [2-aminoethoxydiphenyl borate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Corticosterone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; CREBBP protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Docosahexaenoic Acids inhibits the reaction [Phenylephrine affects the expression of NPPA protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EYA2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Phenylephrine] results in increased expression of NPPA protein]; GLRX3 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPA protein]; IKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; ILK protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Isoproterenol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; kenpaullone promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; leptomycin B inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MBF1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; MEKK1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Metoprolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N(6)-phenyl-cAMP analog inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; NFKBIA protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [CTNNB1 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]; Phenylephrine promotes the reaction [MYOCD protein binds to NPPA promoter]; polydatin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Propranolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]]; Resveratrol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; sanglifehrin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]; SK-7041 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]; trichostatin A inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; triflusal inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; U 0126 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; Uridine Triphosphate inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]; Uridine Triphosphate inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; xestospongin C inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Y 27632 inhibits the reaction [Phenylephrine results in increased expression of NPPA protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
NPPA protein results in decreased susceptibility to Phenylephrine
[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of NPPA mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of NPPA mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUND protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; MOV10L1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

CTD
RGD

PMID:2847676 PMID:8188982 PMID:10642269 PMID:10655507 PMID:10679475 More...

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide B

multiple interactions
increases expression
increases secretion

ISO
EXP

ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; HEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]
phenylephrine increases expression of mRNA in neonatal rat cardiomyocytes
Phenylephrine results in increased expression of NPPB mRNA; Phenylephrine results in increased expression of NPPB protein
(+)-JQ1 compound inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased secretion of NPPB protein]; EP300 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; HS 142-1 promotes the reaction [Phenylephrine results in increased secretion of NPPB protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MOV10L1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MYOCD protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Sildenafil Citrate inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

CTD
RGD

PMID:10642269 PMID:11754973 PMID:11799083 PMID:11804996 PMID:11854500 More...

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

natriuretic peptide C

affects response to substance
multiple interactions

EXP

NPPC protein affects the susceptibility to Phenylephrine
SMR3B protein promotes the reaction [NPPC protein affects the susceptibility to Phenylephrine]

NCBI chr 9:94,767,986...94,772,186
Ensembl chr 9:94,767,986...94,772,186

G

natriuretic peptide receptor 1

multiple interactions

ISO

[NPPA protein results in increased activity of NPR1 protein] promotes the reaction [Phenylephrine results in increased localization of NFATC3 protein]

NCBI chr 2:178,231,766...178,247,591
Ensembl chr 2:178,231,766...178,247,088

G

neuropeptide Y

multiple interactions

ISO

[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]

PMID:10660688 PMID:11499749

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

neuropeptide Y receptor Y5

multiple interactions

ISO

NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]]; NPY5R protein affects the reaction [NPY protein promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]]

NCBI chr16:27,822,055...27,830,012
Ensembl chr16:27,816,065...27,830,290

G

nuclear receptor subfamily 1, group I, member 2

affects response to substance

ISO

NR1I2 protein affects the susceptibility to Phenylephrine

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 3, group C, member 1

increases expression

EXP

Phenylephrine results in increased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions
increases expression

EXP

Phenylephrine promotes the reaction [NR3C2 protein binds to CREBBP protein]; Phenylephrine results in increased expression of and results in increased localization of NR3C2 protein; Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein]
Phenylephrine results in increased expression of NR3C2 mRNA

PMID:16533503 PMID:19966502

NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078

G

nuclear receptor subfamily 4, group A, member 3

increases expression

EXP

Phenylephrine results in increased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

neuronal regeneration related protein

decreases expression

EXP

Phenylephrine results in decreased expression of NREP mRNA

NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742

G

neuregulin 1

decreases expression

EXP

Phenylephrine results in decreased expression of NRG1 mRNA; Phenylephrine results in decreased expression of NRG1 protein

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849

G

neurotensin

decreases response to substance

EXP

NTS protein results in decreased susceptibility to Phenylephrine

NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961

G

nucleoporin 62

multiple interactions
decreases expression

EXP

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]; leptomycin B inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]; trichostatin A inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein]

NCBI chr 1:104,435,532...104,451,392
Ensembl chr 1:104,432,093...104,452,710

G

osteoglycin

decreases expression

EXP

Phenylephrine results in decreased expression of OGN mRNA

NCBI chr17:15,238,500...15,259,167
Ensembl chr17:15,238,500...15,259,252

G

oxytocin/neurophysin I prepropeptide

multiple interactions
increases secretion

EXP

Adenosine Triphosphate promotes the reaction [Phenylephrine results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]

PMID:11102496 PMID:15149956

NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:138,235,754...138,236,594

G

purinergic receptor P2X 5

increases expression

EXP

Phenylephrine results in increased expression of P2RX5 mRNA

NCBI chr10:57,777,737...57,789,426
Ensembl chr10:58,276,257...58,287,935

G

prolyl 4-hydroxylase subunit alpha 1

increases expression

EXP

Phenylephrine results in increased expression of P4HA1 mRNA

NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,845,141...27,895,404

G

proton activated chloride channel 1

decreases expression

EXP

Phenylephrine results in decreased expression of PACC1 mRNA

NCBI chr13:102,904,668...102,929,770
Ensembl chr13:105,435,799...105,461,095

G

platelet-activating factor acetylhydrolase 1b, regulatory subunit 1

multiple interactions

EXP

Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to ATXN1 protein]]; Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to SOX2 protein]]; Phenylephrine inhibits the reaction [Iodine-131 results in decreased expression of PAFAH1B1 protein]

NCBI chr10:59,533,042...59,591,808
Ensembl chr10:60,032,514...60,090,196

G

poly (ADP-ribose) polymerase 1

multiple interactions

EXP

Phenylephrine inhibits the reaction [Oxygen deficiency results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

parvin, alpha

affects localization

EXP

Phenylephrine affects the localization of PARVA protein

NCBI chr 1:166,547,142...166,704,958
Ensembl chr 1:175,981,432...176,139,526

G

proliferating cell nuclear antigen

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of PCNA protein
Phenylephrine promotes the reaction [Iodine-131 results in increased expression of PCNA protein]

PMID:15603588 PMID:32278511

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

Purkinje cell protein 4

decreases expression

EXP

Phenylephrine results in decreased expression of PCP4 mRNA

NCBI chr11:35,759,711...35,861,725
Ensembl chr11:49,270,186...49,331,186

G

proprotein convertase subtilisin/kexin type 6

increases expression

EXP

Phenylephrine results in increased expression of PCSK6 mRNA

NCBI chr 1:128,839,742...129,038,087
Ensembl chr 1:128,839,232...129,052,128

G

phosphodiesterase 1A

multiple interactions

EXP

PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein]

NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:85,154,184...85,519,212

G

phosphodiesterase 4B

increases expression

EXP

Phenylephrine results in increased expression of PDE4B mRNA

NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267

G

phosphodiesterase 5A

multiple interactions

EXP

PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]

NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298

G

pyruvate dehydrogenase kinase 2

decreases expression

EXP

Phenylephrine results in decreased expression of PDK2 mRNA

NCBI chr10:80,469,388...80,483,988
Ensembl chr10:80,469,389...80,484,355

G

pyruvate dehydrogenase kinase 4

multiple interactions
decreases expression

EXP

4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]; parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]

PMID:15721863 PMID:15728586

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381

G

PDZ and LIM domain 3

increases expression

EXP

Phenylephrine results in increased expression of PDLIM3 mRNA

NCBI chr16:53,085,020...53,116,495
Ensembl chr16:53,085,020...53,116,217

G

proliferation and apoptosis adaptor protein 15

increases expression

EXP

Phenylephrine results in increased expression of PEA15 mRNA

NCBI chr13:87,190,189...87,199,811
Ensembl chr13:87,187,295...87,199,859

G

period circadian regulator 1

multiple interactions

ISO

U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER1 mRNA]

NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211

G

period circadian regulator 2

multiple interactions

ISO

U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER2 mRNA]

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993

G

peroxisomal biogenesis factor 11 alpha

decreases expression

EXP

Phenylephrine results in decreased expression of PEX11A mRNA

NCBI chr 1:143,089,410...143,096,491
Ensembl chr 1:143,089,410...143,096,645

G

phosphofructokinase, liver type

increases expression

EXP

Phenylephrine results in increased expression of PFKL mRNA

NCBI chr20:10,663,907...10,685,967
Ensembl chr20:10,663,955...10,685,966

G

phosphoglycerate dehydrogenase

increases expression

EXP

Phenylephrine results in increased expression of PHGDH mRNA

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789

G

pleckstrin homology-like domain, family A, member 1

increases expression

EXP

Phenylephrine results in increased expression of PHLDA1 mRNA

NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:48,853,260...48,857,542

G

polycystin 1, transient receptor potential channel interacting

affects response to substance

ISO

PKD1 protein affects the susceptibility to Phenylephrine

NCBI chr10:14,077,733...14,125,682
Ensembl chr10:14,078,679...14,125,681

G

pyruvate kinase L/R

multiple interactions
decreases activity

EXP

Calcium inhibits the reaction [Phenylephrine results in decreased activity of PKLR protein]

NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644

G

plakophilin 4

decreases expression

EXP

Phenylephrine results in decreased expression of PKP4 mRNA

NCBI chr 3:64,040,995...64,244,586
Ensembl chr 3:64,141,771...64,244,586

G

phospholipase A2 group IIA

decreases expression

EXP

Phenylephrine results in decreased expression of PLA2G2A mRNA

NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297

G

phospholipase A2 group VI

affects response to substance

EXP

PLA2G6 protein affects the susceptibility to Phenylephrine

NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:112,731,803...112,771,609

G

phospholipase A and acyltransferase 1

increases expression

EXP

Phenylephrine results in increased expression of PLAAT1 mRNA

NCBI chr11:71,517,492...71,537,142
Ensembl chr11:85,022,297...85,031,826

G

phospholipase C beta 1

increases expression

EXP

Phenylephrine results in increased expression of PLCB1 mRNA

NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646

G

phospholipase C beta 3

increases expression

EXP

Phenylephrine results in increased expression of PLCB3 mRNA

NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:213,574,166...213,589,583

G

phospholipase C, delta 1

increases expression

EXP

Phenylephrine results in increased expression of PLCD1 mRNA

NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:127,672,980...127,695,939

G

phospholipase C, gamma 1

increases expression

EXP

Phenylephrine results in increased expression of PLCG1 mRNA

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:169,804,846...169,836,050

G

proopiomelanocortin

multiple interactions
increases response to substance
increases secretion

EXP
ISO

Indomethacin inhibits the reaction [Phenylephrine results in increased secretion of POMC protein alternative form]
POMC protein results in increased susceptibility to Phenylephrine

PMID:2822310 PMID:3015460 PMID:10898105

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

peroxisome proliferator activated receptor alpha

multiple interactions
decreases expression

EXP

[pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA mRNA]; AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of PPARA protein]
Phenylephrine results in decreased expression of PPARA mRNA; Phenylephrine results in decreased expression of PPARA protein

PMID:18701451 PMID:19699196

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor delta

multiple interactions

EXP

[4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased activity of PPARD protein] which results in decreased susceptibility to Phenylephrine; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

PMID:15721863 PMID:18701451

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

protein phosphatase 1, regulatory subunit 12A

multiple interactions
increases phosphorylation

EXP

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]; polydatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]; Y 27632 inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]

PMID:24449418 PMID:25449040

NCBI chr 7:45,368,922...45,480,158
Ensembl chr 7:45,369,315...45,480,157

G

protein phosphatase 1, regulatory (inhibitor) subunit 14A

multiple interactions
increases phosphorylation

EXP

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]

NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:93,708,218...93,719,147

G

protein phosphatase 3 catalytic subunit beta

increases expression
increases activity
multiple interactions

ISO
EXP

Phenylephrine results in increased expression of PPP3CB mRNA
Phenylephrine results in increased expression of PPP3CB mRNA; Phenylephrine results in increased expression of PPP3CB protein
Phenylephrine results in increased activity of PPP3CB protein
CABIN1 protein inhibits the reaction [Phenylephrine results in increased activity of PPP3CB protein]

PMID:10655507 PMID:16024800

NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,809,262...3,854,203

G

protein kinase C, alpha

multiple interactions
increases expression
increases activity
increases localization

ISO
EXP

DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCA protein]; Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCA protein]
Phenylephrine results in increased expression of PRKCA protein modified form
GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of PRKCA protein modified form]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCA protein
Phenylephrine results in increased activity of PRKCA protein

PMID:12435817 PMID:16809552 PMID:18487437 PMID:21565836

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, beta

multiple interactions
increases expression

EXP

Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]; RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein]

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

protein kinase C, delta

increases expression
affects localization

EXP

Phenylephrine results in increased expression of PRKCD protein
Phenylephrine affects the localization of PRKCD protein

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

protein kinase C, epsilon

multiple interactions
increases expression
affects localization
increases localization

ISO
EXP

DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein]; Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCE protein]
Phenylephrine results in increased expression of PRKCE protein
Phenylephrine affects the localization of PRKCE protein
[chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrine; GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein

PMID:12003851 PMID:12700091 PMID:12720544 PMID:16809552 PMID:18487437

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

protein kinase C, zeta

affects localization
increases phosphorylation
decreases activity
multiple interactions

EXP

Phenylephrine affects the localization of PRKCZ protein
Phenylephrine results in increased phosphorylation of PRKCZ protein
Phenylephrine results in decreased activity of PRKCZ protein
GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]

PMID:14736339 PMID:16809552 PMID:27094369

NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674

G

protein kinase D1

affects localization
increases phosphorylation
multiple interactions
increases activity

ISO
EXP

Phenylephrine affects the localization of PRKD1 protein
Phenylephrine increases phosphorylation of Prkd1 protein in neonatal ventricular myocytes
[Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein

CTD
RGD

PMID:19124542 PMID:16648482

NCBI chr 6:73,460,640...73,774,433
Ensembl chr 6:73,460,640...73,836,509

G

protein kinase cGMP-dependent 1

multiple interactions
increases expression
increases activity
decreases activity

EXP

[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [Phenylephrine co-treated with Copper] results in increased activity of PRKG1 protein; [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; FLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]; PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein]; Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 mRNA]; Phenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 protein]; VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]; VIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]
Phenylephrine results in increased expression of PRKG1 protein

PMID:11799084 PMID:16378109 PMID:19542178 PMID:19797176 PMID:26168186

NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005

G

protein C receptor

increases expression

EXP

Phenylephrine results in increased expression of PROCR mRNA

NCBI chr 3:164,714,727...164,718,994
Ensembl chr 3:164,711,636...164,718,989

G

phosphoserine phosphatase

increases expression

EXP

Phenylephrine results in increased expression of PSPH mRNA

NCBI chr12:26,882,524...26,905,084
Ensembl chr12:32,519,269...32,541,180

G

prostaglandin I2 synthase

increases expression

EXP

Phenylephrine results in increased expression of PTGIS mRNA

NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650

G

prostaglandin-endoperoxide synthase 1

multiple interactions
affects response to substance

ISO

FBN1 protein affects the reaction [PTGS1 protein affects the susceptibility to Phenylephrine]

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

EXP

Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein]

PMID:17244722 PMID:18701451

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

parathyroid hormone-like hormone

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of PTHLH mRNA; Phenylephrine results in increased expression of PTHLH protein
PTHLH protein affects the reaction [Phenylephrine results in decreased expression of BAX protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of BCL2 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]

NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454

G

protein tyrosine phosphatase, receptor type, F

decreases expression

EXP

Phenylephrine results in decreased expression of PTPRF mRNA

NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:137,028,164...137,095,426

G

protein tyrosine phosphatase, receptor type, K

decreases expression

EXP

Phenylephrine results in decreased expression of PTPRK mRNA

NCBI chr 1:16,738,896...17,236,687
Ensembl chr 1:18,558,365...19,056,107

G

PVR cell adhesion molecule

increases expression

EXP

Phenylephrine results in increased expression of PVR mRNA

NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:88,688,981...88,704,630

G

PYD and CARD domain containing

decreases expression

EXP

Phenylephrine results in decreased expression of PYCARD mRNA

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419

G

glycogen phosphorylase L

multiple interactions
increases expression

EXP

[Phenylephrine co-treated with Calcium] results in increased activity of PYGL protein; Glucose inhibits the reaction [[Phenylephrine co-treated with Calcium] results in increased activity of PYGL protein]
Phenylephrine results in increased expression of PYGL mRNA

PMID:747652 PMID:18158353

NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:94,426,346...94,476,269

G

RAB3B, member RAS oncogene family

decreases expression

EXP

Phenylephrine results in decreased expression of RAB3B mRNA

NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:128,841,716...128,926,086

G

Rac family small GTPase 1

increases activity

EXP

Phenylephrine results in increased activity of RAC1 protein

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions
increases phosphorylation

EXP

Docosahexaenoic Acids inhibits the reaction [Phenylephrine results in increased phosphorylation of RAF1 protein]

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:150,352,160...150,412,813

G

retinoic acid induced 14

increases expression

EXP

Phenylephrine results in increased expression of RAI14 mRNA

NCBI chr 2:59,546,284...59,682,687
Ensembl chr 2:61,273,439...61,409,791

G

receptor activity modifying protein 1

affects expression

EXP

Phenylephrine affects the expression of RAMP1 mRNA

NCBI chr 9:99,213,031...99,263,696

G

receptor activity modifying protein 2

multiple interactions
increases expression
decreases expression

EXP

[Phenylephrine co-treated with Isoproterenol] results in increased expression of RAMP2 mRNA
Phenylephrine results in increased expression of RAMP2 mRNA
Phenylephrine results in decreased expression of RAMP2 mRNA

PMID:12899678 PMID:17250927

NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,688,703...86,691,231

G

receptor activity modifying protein 3

increases expression

EXP

Phenylephrine results in increased expression of RAMP3 mRNA

NCBI chr14:81,527,404...81,544,905
Ensembl chr14:85,755,211...85,758,818

G

RAN binding protein 1

multiple interactions

EXP

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]; leptomycin B inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]; Phenylephrine affects the localization of and affects the expression of RANBP1 protein; trichostatin A inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]

NCBI chr11:96,246,912...96,255,145
Ensembl chr11:96,246,740...96,255,145

G

Rap guanine nucleotide exchange factor 4

increases expression

EXP

Phenylephrine results in increased expression of RAPGEF4 mRNA

NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:77,217,039...77,509,978

G

receptor-associated protein of the synapse

decreases expression

EXP

Phenylephrine results in decreased expression of RAPSN mRNA

NCBI chr 3:97,470,891...97,480,196
Ensembl chr 3:97,470,881...97,480,196

G

RASD family, member 2

decreases expression

EXP

Phenylephrine results in decreased expression of RASD2 mRNA

NCBI chr19:13,594,291...13,605,016
Ensembl chr19:13,599,986...13,610,753

G

Ras association domain family member 1

decreases response to substance

ISO
EXP

RASSF1 protein results in decreased susceptibility to Phenylephrine

NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:117,103,362...117,114,805

G

RB transcriptional corepressor 1

increases expression
affects phosphorylation

EXP

Phenylephrine results in increased expression of RB1 protein
Phenylephrine affects the phosphorylation of RB1 protein

PMID:15603588 PMID:18084315

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RANBP2-type and C3HC4-type zinc finger containing 1

multiple interactions
affects response to substance

EXP

Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]; Phenylephrine results in increased phosphorylation of and results in increased expression of RBCK1 protein; RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein]
RBCK1 protein affects the susceptibility to Phenylephrine

NCBI chr 3:161,249,389...161,266,321
Ensembl chr 3:161,249,390...161,266,032

G

RNA binding fox-1 homolog 2

EXP

Phenylephrine increases expression of Rbfox2 mRNA and protein in vascular smooth muscle cells

RGD

NCBI chr 7:110,691,230...110,934,901
Ensembl chr 7:110,691,230...110,934,987

G

regulator of calcineurin 1

increases expression
multiple interactions

ISO
EXP

Phenylephrine results in increased expression of RCAN1 protein
Phenylephrine results in increased expression of RCAN1 mRNA
MYOZ2 protein inhibits the reaction [Phenylephrine results in increased expression of RCAN1 protein]

PMID:18025526 PMID:25358972

NCBI chr11:45,108,123...45,188,065
Ensembl chr11:45,108,124...45,118,236

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases activity
affects localization

EXP

[GW 501516 binds to PPARD protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]; [pirinixic acid binds to PPARA protein] inhibits the reaction [Phenylephrine results in increased activity of RELA protein]
Phenylephrine affects the localization of RELA protein

PMID:11381115 PMID:18701451

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

renin

decreases activity
affects response to substance

ISO

Phenylephrine results in decreased activity of REN protein
REN1 protein affects the susceptibility to Phenylephrine

PMID:2847676 PMID:17679040

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543

G

REV3 like, DNA directed polymerase zeta catalytic subunit

decreases expression

EXP

Phenylephrine results in decreased expression of REV3L mRNA

NCBI chr20:43,131,841...43,290,102
Ensembl chr20:44,686,940...44,844,668

G

regulator of G-protein signaling 2

multiple interactions
increases expression
affects response to substance

EXP
ISO

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; 2-Chloroadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
RGS2 protein affects the susceptibility to Phenylephrine

PMID:15452191 PMID:16517124 PMID:17644703 PMID:18158353

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697

G

regulator of G-protein signaling 3

multiple interactions

ISO

RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:81,056,068...81,177,445

G

regulator of G-protein signaling 4

multiple interactions

ISO

RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884

G

ras homolog family member A

multiple interactions
increases activity

EXP

geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]; monomethylarsonous acid promotes the reaction [Phenylephrine results in increased activity of RHOA protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]; Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]; polydatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]; RHOA protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R12A protein]]; Simvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]; Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]

PMID:10843871 PMID:15081308 PMID:21708234 PMID:24449418 PMID:25449040

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302

G

receptor interacting serine/threonine kinase 1

increases expression

ISO

Phenylephrine results in increased expression of RIPK1 protein

NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167

G

receptor-interacting serine-threonine kinase 3

increases expression

ISO

Phenylephrine results in increased expression of RIPK3 protein

NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025

G

Rho family GTPase 1

increases expression

EXP

Phenylephrine results in increased expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:131,700,321...131,707,392

G

ring finger protein 39

increases expression

EXP

Phenylephrine results in increased expression of RNF39 mRNA

NCBI chr20:1,604,794...1,610,283
Ensembl chr20:1,610,026...1,612,323

G

Rho-associated coiled-coil containing protein kinase 2

increases expression

EXP

Phenylephrine results in increased expression of ROCK2 mRNA

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771

G

ribosomal protein S6 kinase A5

multiple interactions

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein; RPS6KA5 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]

PMID:15522277 PMID:19002563

NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:125,558,434...125,735,856

G

ribosomal protein S6 kinase B1

multiple interactions
increases phosphorylation

EXP

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; resveratrol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]

PMID:12411397 PMID:12720544 PMID:12935885 PMID:15757502 PMID:15795328 More...

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

ribosomal protein S6 kinase B2

multiple interactions

EXP

bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]

NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:210,880,825...210,887,562

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

decreases expression

EXP

Phenylephrine results in decreased expression of RRAD protein

NCBI chr19:360,581...363,874
Ensembl chr19:360,973...363,871

G

RUNX1 partner transcriptional co-repressor 1

decreases expression

EXP

Phenylephrine results in decreased expression of RUNX1T1 mRNA

NCBI chr 5:31,984,946...32,136,878
Ensembl chr 5:31,984,855...32,132,855

G

S100 calcium binding protein A6

multiple interactions

EXP

S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA]

NCBI chr 2:178,398,189...178,399,763
Ensembl chr 2:178,398,481...178,399,762

G

S100 calcium binding protein B

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of S100B mRNA
S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]

NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081

G

sterol-C5-desaturase

increases expression

EXP

Phenylephrine results in increased expression of SC5D mRNA

NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277

G

stearoyl-Coenzyme A desaturase 2

increases expression

EXP

Phenylephrine results in increased expression of SCD2 mRNA

NCBI chr 1:253,118,377...253,131,436
Ensembl chr 1:253,117,655...253,128,874

G

synthesis of cytochrome C oxidase 2

multiple interactions
decreases expression

EXP

VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of SCO2 protein]

G

selenium binding protein 1

decreases expression

EXP

Phenylephrine results in decreased expression of SELENBP1 mRNA

NCBI chr 2:185,183,022...185,193,612
Ensembl chr 2:185,183,004...185,194,295

G

semaphorin 6D

decreases expression

EXP

Phenylephrine results in decreased expression of SEMA6D mRNA

NCBI chr 3:111,883,415...111,941,100
Ensembl chr 3:132,337,343...132,394,584

G

septin 5

increases expression

EXP

Phenylephrine results in increased expression of SEPTIN5 mRNA

NCBI chr11:82,373,601...82,379,393
Ensembl chr11:95,873,864...95,883,737

G

serpin family E member 1

increases expression

ISO
EXP

Phenylephrine results in increased expression of SERPINE1 mRNA

PMID:15808835 PMID:15850565

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

serum/glucocorticoid regulated kinase 1

increases phosphorylation
multiple interactions

EXP

Phenylephrine results in increased phosphorylation of SGK1 protein
Phenylephrine promotes the reaction [Cortisone results in increased expression of SGK1 mRNA]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]; SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]

PMID:15795328 PMID:16533503

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

salt-inducible kinase 1

increases expression

EXP

Phenylephrine results in increased expression of SIK1 mRNA

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,105...9,958,698

G

sirtuin 6

multiple interactions

EXP

[SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; [SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; Phenylephrine results in decreased expression of and results in decreased activity of SIRT6 protein; SIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; SIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]

NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,732,974...8,738,542

G

solute carrier family 12 member 2

multiple interactions

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine promotes the reaction [SLC12A2 protein results in increased uptake of Rubidium]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased phosphorylation of SLC12A2 protein]; Phenylephrine promotes the reaction [SLC12A2 protein results in increased uptake of Rubidium]

NCBI chr18:53,546,263...53,614,478
Ensembl chr18:53,546,333...53,614,470

G

solute carrier family 16 member 10

decreases expression

EXP

Phenylephrine results in decreased expression of SLC16A10 mRNA

NCBI chr20:45,014,229...45,122,392
Ensembl chr20:45,014,235...45,122,358

G

solute carrier family 16 member 3

increases expression

EXP

Phenylephrine results in increased expression of SLC16A3 mRNA

NCBI chr10:106,712,328...106,756,168
Ensembl chr10:106,714,466...106,720,903

G

solute carrier family 16 member 7

decreases expression

EXP

Phenylephrine results in decreased expression of SLC16A7 mRNA

NCBI chr 7:62,929,067...63,096,995
Ensembl chr 7:62,936,567...63,040,386

G

solute carrier family 1 member 3

increases expression

EXP

Phenylephrine results in increased expression of SLC1A3 mRNA

NCBI chr 2:59,482,707...59,557,808
Ensembl chr 2:59,482,709...59,557,808

G

solute carrier family 22 member 1

multiple interactions

EXP

[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 3

multiple interactions

EXP

[Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased import of Phenylephrine

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 26 member 6

decreases activity
increases expression

EXP

Phenylephrine results in decreased activity of SLC26A6 protein
Phenylephrine results in increased expression of SLC26A6 protein

NCBI chr 8:118,438,110...118,448,271
Ensembl chr 8:118,438,180...118,448,270

G

solute carrier family 29 member 1

increases expression

EXP

Phenylephrine results in increased expression of SLC29A1 mRNA

NCBI chr 9:22,897,099...22,911,640
Ensembl chr 9:22,902,471...22,914,620

G

solute carrier family 2 member 1

increases expression

EXP

Phenylephrine results in increased expression of SLC2A1 mRNA

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 4 member 1 adaptor protein

decreases expression

EXP

Phenylephrine results in decreased expression of SLC4A1AP mRNA

NCBI chr 6:24,905,941...24,933,651
Ensembl chr 6:30,625,931...30,653,792

G

solute carrier family 4 member 3

increases activity

EXP

Phenylephrine results in increased activity of SLC4A3 protein

NCBI chr 9:77,036,243...77,053,940
Ensembl chr 9:84,485,085...84,497,738

G

solute carrier family 7 member 1

increases expression

EXP

Phenylephrine results in increased expression of SLC7A1 mRNA

NCBI chr12:11,664,488...11,740,030
Ensembl chr12:11,664,399...11,740,030

G

solute carrier family 8 member A1

multiple interactions
increases expression
decreases expression

ISO
EXP

EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]; EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]; Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]
Phenylephrine results in increased expression of SLC8A1 mRNA
Phenylephrine results in decreased expression of SLC8A1 protein

PMID:11179087 PMID:15621046 PMID:19244478

NCBI chr 6:18,975,498...19,299,704
Ensembl chr 6:18,946,798...19,287,964

G

solute carrier family 9 member A1

multiple interactions
increases expression
increases activity

EXP

2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; 3-methylsulfonyl-4-piperidinobenzoyl guanidine inhibits the reaction [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 mRNA]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SLC9A1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Phenylephrine results in increased expression of SLC9A1 mRNA; Phenylephrine results in increased expression of SLC9A1 protein

PMID:15452191 PMID:16236312 PMID:16513848 PMID:16517124

NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517

G

SMAD family member 2

multiple interactions

EXP

Phenylephrine results in increased phosphorylation of and results in increased localization of and results in increased activity of SMAD2 protein

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388

G

SPARC related modular calcium binding 2

decreases expression

EXP

Phenylephrine results in decreased expression of SMOC2 mRNA

NCBI chr 1:63,935,627...64,064,952
Ensembl chr 1:63,935,647...64,064,955

G

submaxillary gland androgen regulated protein 3B

multiple interactions

EXP

SMR3B protein promotes the reaction [NPPC protein affects the susceptibility to Phenylephrine]

NCBI chr14:19,783,815...19,788,557
Ensembl chr14:20,067,851...20,072,527

G

sorbitol dehydrogenase

decreases expression

EXP

Phenylephrine results in decreased expression of SORD mRNA

NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:129,638,302...129,686,100

G

SRY-box transcription factor 2

multiple interactions

EXP

Phenylephrine inhibits the reaction [Iodine-131 inhibits the reaction [PAFAH1B1 protein binds to SOX2 protein]]

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350

G

SRY-box transcription factor 6

decreases expression

EXP

Phenylephrine results in decreased expression of SOX6 mRNA

NCBI chr 1:179,157,678...179,769,243
Ensembl chr 1:179,163,566...179,711,727

G

Sp1 transcription factor

multiple interactions

ISO

[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA]

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513

G

secreted phosphoprotein 1

increases expression

EXP

Phenylephrine results in increased expression of SPP1 protein

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

sprouty RTK signaling antagonist 1

increases expression

EXP

Phenylephrine results in increased expression of SPRY1 mRNA

NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:122,484,355...122,492,956

G

spectrin, alpha, erythrocytic 1

decreases expression

EXP

Phenylephrine results in decreased expression of SPTA1 mRNA

NCBI chr13:88,735,833...88,811,697
Ensembl chr13:88,735,833...88,811,697

G

squalene epoxidase

increases expression

EXP

Phenylephrine results in increased expression of SQLE mRNA

NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050

G

sequestosome 1

decreases expression

EXP

Phenylephrine results in decreased expression of SQSTM1 mRNA

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

increases expression

EXP

Phenylephrine results in increased expression of ST3GAL2 mRNA

NCBI chr19:38,888,851...38,939,874
Ensembl chr19:55,799,471...55,849,225

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

increases expression

EXP

Phenylephrine results in increased expression of ST3GAL4 mRNA

NCBI chr 8:33,415,666...33,465,319
Ensembl chr 8:41,673,510...41,712,551

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

increases expression

EXP

Phenylephrine results in increased expression of ST8SIA5 mRNA

NCBI chr18:70,736,395...70,802,537
Ensembl chr18:73,011,383...73,072,991

G

signal transducer and activator of transcription 1

decreases expression

EXP

Phenylephrine results in decreased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

affects localization
increases expression
multiple interactions

EXP

Phenylephrine affects the localization of STAT3 protein
Phenylephrine results in increased expression of STAT3
Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]; Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein; Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein; PRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]; Verapamil inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased expression of STAT3 protein]

PMID:19299911 PMID:27094369

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

stanniocalcin 1

affects expression

EXP

Phenylephrine affects the expression of STC1 mRNA

NCBI chr15:50,709,439...50,720,093
Ensembl chr15:50,709,415...50,720,082

G

stathmin 1

decreases expression

EXP

Phenylephrine results in decreased expression of STMN1 mRNA

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842

G

syntaxin 11

affects expression

EXP

Phenylephrine affects the expression of STX11 mRNA

NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:9,107,796...9,178,455

G

tachykinin, precursor 1

multiple interactions
increases secretion
affects response to substance

EXP

alfuzosin inhibits the reaction [Phenylephrine results in increased secretion of TAC1 protein]
TAC1 protein affects the susceptibility to Phenylephrine

PMID:11270094 PMID:17240043

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546

G

tachykinin receptor 1

increases response to substance

EXP

TACR1 protein results in increased susceptibility to Phenylephrine

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:116,478,617...116,647,492

G

TATA-box binding protein associated factor 1

increases expression

EXP

Phenylephrine results in increased expression of TAF1 mRNA

NCBI chr X:66,640,915...66,716,543
Ensembl chr X:70,680,906...70,756,735

G

t-complex-associated testis expressed 1

decreases expression

EXP

Phenylephrine results in decreased expression of TCTE1 mRNA

NCBI chr 9:15,463,573...15,482,258
Ensembl chr 9:22,961,176...22,970,391

G

transcription factor Dp-1

increases expression

EXP

Phenylephrine results in increased expression of TFDP1 protein

NCBI chr16:76,162,040...76,200,871
Ensembl chr16:82,864,226...82,902,996

G

transforming growth factor, beta 1

increases expression

ISO
EXP

Phenylephrine results in increased expression of TGFB1 mRNA
Phenylephrine results in increased expression of TGFB1 mRNA; Phenylephrine results in increased expression of TGFB1 protein

PMID:10406839 PMID:11821714 PMID:19443575

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor beta 1 induced transcript 1

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of TGFB1I1 protein
[Phenylephrine results in increased phosphorylation of MAPK1 protein] which affects the expression of TGFB1I1 protein; [Phenylephrine results in increased phosphorylation of MAPK3 protein] which affects the expression of TGFB1I1 protein; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]

NCBI chr 1:192,258,992...192,265,903
Ensembl chr 1:192,258,598...192,265,903

G

transforming growth factor, beta 2

increases expression

EXP

Phenylephrine results in increased expression of TGFB2 mRNA

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856

G

transforming growth factor, beta 3

increases expression

EXP

Phenylephrine results in increased expression of TGFB3 mRNA

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946

G

transforming growth factor, beta receptor 1

increases expression

EXP

Phenylephrine results in increased expression of TGFBR1 mRNA

NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260

G

transforming growth factor, beta receptor 2

increases expression

EXP

Phenylephrine results in increased expression of TGFBR2 mRNA

NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469

G

transglutaminase 2

multiple interactions
decreases activity
increases expression

EXP

ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; Ethanol inhibits the reaction [Phenylephrine results in decreased activity of TGM2 protein]
Phenylephrine results in increased expression of TGM2 mRNA

PMID:10801782 PMID:18158353

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:167,192,612...167,304,240

G

thyroid hormone receptor alpha

multiple interactions
increases expression

EXP

THRA protein affects the reaction [Phenylephrine results in decreased expression of MYH6 protein]
Phenylephrine results in increased expression of THRA protein

PMID:11577024 PMID:17389455

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:84,197,011...84,225,657

G

thyroid hormone receptor beta

decreases expression
increases expression
multiple interactions

EXP

Phenylephrine results in decreased expression of THRB mRNA; Phenylephrine results in decreased expression of THRB protein
Phenylephrine results in increased expression of THRB protein
THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; THRB protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB mRNA]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of THRB protein]

PMID:11577024 PMID:17389455

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

TIMP metallopeptidase inhibitor 1

multiple interactions
increases expression

EXP

BCL2 protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 mRNA]; PTHLH protein affects the reaction [Phenylephrine results in increased expression of TIMP1 protein]
Phenylephrine results in increased expression of TIMP1 mRNA; Phenylephrine results in increased expression of TIMP1 protein

PMID:18158353 PMID:19910689

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

transmembrane protein 140

decreases expression

EXP

Phenylephrine results in decreased expression of TMEM140 mRNA

NCBI chr 4:63,536,477...63,547,478
Ensembl chr 4:64,500,439...64,521,990

G

transmembrane protein 176B

decreases expression

EXP

Phenylephrine results in decreased expression of TMEM176B mRNA

NCBI chr 4:77,766,928...77,774,740
Ensembl chr 4:79,097,808...79,105,263

G

transmembrane protein 43

increases expression

EXP

Phenylephrine results in increased expression of TMEM43 mRNA

NCBI chr 4:123,977,680...123,992,823
Ensembl chr 4:125,534,813...125,549,988

G

thymosin beta 15B2

increases expression

EXP

Phenylephrine results in increased expression of TMSB15B2 mRNA

NCBI chr X:105,090,980...105,093,094
Ensembl chr X:105,090,980...105,093,094

G

tumor necrosis factor

decreases secretion
decreases response to substance
increases expression
multiple interactions

EXP

Phenylephrine results in decreased secretion of TNF protein
TNF protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in increased expression of TNF mRNA; Phenylephrine results in increased expression of TNF protein
Phenylephrine promotes the reaction [FOXO1 protein results in increased expression of TNF mRNA]; Pilocarpine inhibits the reaction [Phenylephrine results in increased expression of TNF protein]

PMID:12423672 PMID:13679239 PMID:16020479 PMID:17872965 PMID:18701451

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

increases expression

ISO

Phenylephrine results in increased expression of TNFAIP3 protein

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF receptor superfamily member 12A

increases expression

EXP

Phenylephrine results in increased expression of TNFRSF12A mRNA

NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704

G

TNF superfamily member 11

increases expression
multiple interactions

ISO

Phenylephrine results in increased expression of TNFSF11 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA]

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

thymocyte selection-associated high mobility group box

decreases expression

EXP

Phenylephrine results in decreased expression of TOX mRNA

NCBI chr 5:24,672,487...24,968,754
Ensembl chr 5:24,672,487...24,968,754

G

tropomyosin 2

increases expression

EXP

Phenylephrine results in increased expression of TPM2 mRNA

NCBI chr 5:62,566,712...62,576,066
Ensembl chr 5:62,566,652...62,575,726

G

triadin

decreases expression

EXP

Phenylephrine results in decreased expression of TRDN mRNA

NCBI chr 1:25,774,765...26,230,069
Ensembl chr 1:25,774,765...26,229,717

G

tribbles pseudokinase 3

increases expression

EXP

Phenylephrine results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

tripartite motif-containing 2

decreases expression

EXP

Phenylephrine results in decreased expression of TRIM2 mRNA

NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:171,798,660...171,913,468

G

tripartite motif-containing 25

decreases expression

EXP

Phenylephrine results in decreased expression of TRIM25 mRNA

NCBI chr10:74,310,024...74,328,473
Ensembl chr10:74,310,022...74,331,716

G

tripartite motif-containing 34

decreases expression

EXP

Phenylephrine results in decreased expression of TRIM34 mRNA

NCBI chr 1:168,119,043...168,130,544
Ensembl chr 1:168,119,074...168,132,059

G

transient receptor potential cation channel, subfamily C, member 1

increases expression

EXP

Phenylephrine results in increased expression of TRPC1 protein

NCBI chr 8:105,142,931...105,193,842
Ensembl chr 8:105,142,931...105,193,826

G

transient receptor potential cation channel, subfamily C, member 3

multiple interactions
increases expression

EXP

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium]; [Phenylephrine results in increased expression of TRPC3 protein] which results in increased transport of Calcium; TRPC3 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]
Phenylephrine results in increased expression of TRPC3 mRNA; Phenylephrine results in increased expression of TRPC3 protein

PMID:15672411 PMID:19244478

NCBI chr 2:121,409,436...121,487,095
Ensembl chr 2:121,409,436...121,475,823

G

transient receptor potential cation channel, subfamily C, member 6

multiple interactions

EXP

TRPC6 protein promotes the reaction [Phenylephrine results in increased transport of Calcium]

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:14,043,877...14,149,304

G

transient receptor potential cation channel, subfamily M, member 8

multiple interactions

EXP

6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]]; capsazepine inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; icilin inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Menthol inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Phenanthrolines inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; Phenylephrine binds to and results in increased activity of TRPM8 protein

NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:96,351,681...96,436,617

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

ISO

TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with calcitonin gene-related peptide (8-37)]; TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with capsazepine]

NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021

G

TSC complex subunit 2

multiple interactions
increases phosphorylation

EXP

SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]; U 0126 inhibits the reaction [Phenylephrine results in increased phosphorylation of TSC2 protein]

PMID:15757502 PMID:15795328

NCBI chr10:14,125,679...14,160,317
Ensembl chr10:14,125,680...14,160,600

G

tubulin, beta 6 class V

increases expression

EXP

Phenylephrine results in increased expression of TUBB6 mRNA

NCBI chr18:63,213,287...63,222,926
Ensembl chr18:63,213,279...63,224,303

G

tyrosinase

multiple interactions
increases activity

EXP

Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

ubinuclein 1

decreases expression

EXP

Phenylephrine results in decreased expression of UBN1 mRNA

NCBI chr10:11,003,036...11,038,466
Ensembl chr10:11,003,036...11,038,466

G

ubiquitin C-terminal hydrolase L1

increases expression

EXP

Phenylephrine results in increased expression of UCHL1 mRNA

NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,838,861...41,849,417

G

urocortin

affects response to substance

EXP

UCN protein affects the susceptibility to Phenylephrine

NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:30,957,383...30,959,422

G

vascular cell adhesion molecule 1

decreases expression

EXP

Phenylephrine results in decreased expression of VCAM1 mRNA

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

versican

increases expression

EXP

Phenylephrine results in increased expression of VCAN mRNA

NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:22,497,035...22,595,955

G

vascular endothelial growth factor A

multiple interactions

EXP

VEGFA protein inhibits the reaction [Phenylephrine results in decreased abundance of Copper]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX11 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of COX17 protein]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased expression of SCO2 protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

vimentin

increases expression
multiple interactions

EXP

Phenylephrine results in increased expression of VIM protein
VIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]; VIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

vasoactive intestinal peptide

affects response to substance

ISO

VIP protein affects the susceptibility to Phenylephrine

NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:44,470,462...44,478,558

G

WASP like actin nucleation promoting factor

multiple interactions

EXP

ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]

NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:54,049,082...54,097,570

G

WAP four-disulfide core domain 1

increases expression

EXP

Phenylephrine results in increased expression of WFDC1 mRNA

NCBI chr19:64,628,689...64,647,739
Ensembl chr19:64,607,794...64,648,028

G

Wnt inhibitory factor 1

increases expression

EXP

Phenylephrine results in increased expression of WIF1 mRNA

NCBI chr 7:58,433,326...58,503,853
Ensembl chr 7:58,384,643...58,503,852

G

xenotropic and polytropic retrovirus receptor 1

increases expression

EXP

Phenylephrine results in increased expression of XPR1 mRNA

NCBI chr13:69,991,517...70,136,249
Ensembl chr13:69,996,692...70,136,164

G

zinc finger DHHC-type palmitoyltransferase 2

increases expression

EXP

Phenylephrine results in increased expression of ZDHHC2 mRNA

NCBI chr16:51,808,465...51,878,060
Ensembl chr16:58,511,934...58,581,516

G

zinc finger protein 46

decreases expression

EXP

Phenylephrine results in decreased expression of ZFP46 mRNA

NCBI chr 5:148,519,398...148,529,903
Ensembl chr 5:153,802,834...153,812,941

G

zinc finger protein 503

decreases expression

EXP

Phenylephrine results in decreased expression of ZFP503 mRNA

NCBI chr15:2,313,060...2,316,848
Ensembl chr15:2,362,427...2,366,238

G

zinc finger protein, multitype 2

decreases response to substance
multiple interactions

ISO
EXP

ZFPM2 protein results in decreased susceptibility to Phenylephrine
ZFPM2 protein inhibits the reaction [Phenylephrine promotes the reaction [GATA4 protein binds to EP300 protein]]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased activity of GATA4 protein]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

NCBI chr 7:73,563,732...74,001,041
Ensembl chr 7:73,563,732...74,001,041

phenylpropanolamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

multiple interactions

ISO

Phenylpropanolamine binds to and results in decreased activity of ADRA1A protein

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

adrenoceptor alpha 2A

affects binding

ISO

Phenylpropanolamine binds to ADRA2A protein

NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871

G

adrenoceptor alpha 2C

affects binding

ISO

Phenylpropanolamine binds to ADRA2C protein

NCBI chr14:75,470,884...75,472,846
Ensembl chr14:79,694,995...79,706,656

G

aldolase, fructose-bisphosphate C

decreases expression

ISO

Phenylpropanolamine results in decreased expression of ALDOA mRNA

NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,715,489...63,719,133

G

ATP synthase F1 subunit gamma

decreases expression

ISO

Phenylpropanolamine results in decreased expression of ATP5F1C mRNA

NCBI chr17:73,333,584...73,355,872
Ensembl chr17:73,333,588...73,383,073

G

ATPase H+ transporting accessory protein 1

decreases expression

ISO

Phenylpropanolamine results in decreased expression of ATP6AP1 mRNA

NCBI chr X:157,231,243...157,238,323
Ensembl chr X:157,225,327...157,238,323

G

ATPase H+ transporting V0 subunit C

decreases expression

ISO

Phenylpropanolamine results in decreased expression of ATP6V0C mRNA

NCBI chr10:13,700,764...13,707,147
Ensembl chr10:13,700,764...13,706,245

G

ATPase H+ transporting V1 subunit B2

decreases expression

ISO

Phenylpropanolamine results in decreased expression of ATP6V1B2 mRNA

NCBI chr16:25,384,254...25,408,388
Ensembl chr16:25,384,257...25,408,839

G

ATPase H+ transporting V1 subunit E1

decreases expression

ISO

Phenylpropanolamine results in decreased expression of ATP6V1E1 mRNA

NCBI chr 4:155,694,534...155,716,660
Ensembl chr 4:155,694,534...155,716,678

G

catalase

multiple interactions
increases expression

EXP

Enzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in increased expression of CAT protein]; S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of CAT mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of CAT mRNA]
Phenylpropanolamine results in increased expression of CAT mRNA; Phenylpropanolamine results in increased expression of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cAMP responsive element binding protein 1

increases expression
multiple interactions

EXP

Phenylpropanolamine results in increased expression of CREB1 mRNA
Phenylpropanolamine results in increased expression of and results in increased activity of CREB1 protein

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

cytochrome P450, family 51

increases expression

ISO

Phenylpropanolamine results in increased expression of CYP51A1 mRNA

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

7-dehydrocholesterol reductase

increases expression

ISO

Phenylpropanolamine results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:208,444,434...208,461,382

G

farnesyl diphosphate farnesyl transferase 1

increases expression

ISO

Phenylpropanolamine results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:41,588,117...41,616,168

G

farnesyl diphosphate synthase

increases expression

ISO

Phenylpropanolamine results in increased expression of FDPS mRNA

NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136

G

glutathione peroxidase 1

increases expression

EXP

Phenylpropanolamine results in increased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione S-transferase alpha 1

multiple interactions
increases expression

EXP

Enzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in increased expression of GSTA1 protein]; S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of GSTA1 mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of GSTA1 mRNA]
Phenylpropanolamine results in increased expression of GSTA1 mRNA; Phenylpropanolamine results in increased expression of GSTA1 protein

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

hexokinase 1

decreases expression

ISO

Phenylpropanolamine results in decreased expression of HK1 mRNA

NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression

ISO

Phenylpropanolamine results in increased expression of HMGCR mRNA

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

ISO

Phenylpropanolamine results in increased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

isopentenyl-diphosphate delta isomerase 1

increases expression

ISO

Phenylpropanolamine results in increased expression of IDI1 mRNA

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

Janus kinase 2

increases expression

EXP

Phenylpropanolamine results in increased expression of JAK2 mRNA; Phenylpropanolamine results in increased expression of JAK2 protein

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

lysosomal-associated membrane protein 1

affects localization

ISO

Phenylpropanolamine affects the localization of LAMP1 protein

NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159

G

lactate dehydrogenase B

decreases expression

ISO

Phenylpropanolamine results in decreased expression of LDHB mRNA

NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:177,159,392...177,177,408

G

low density lipoprotein receptor

increases expression

ISO

Phenylpropanolamine results in increased expression of LDLR mRNA

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

lanosterol synthase

increases expression

ISO

Phenylpropanolamine results in increased expression of LSS mRNA

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253

G

lysophospholipase 1

increases expression

ISO

Phenylpropanolamine results in increased expression of LYPLA1 mRNA

NCBI chr 5:19,477,408...19,506,568
Ensembl chr 5:19,477,409...19,506,522

G

monoamine oxidase A

multiple interactions
decreases activity

ISO
EXP

Phenylpropanolamine inhibits the reaction [MAOA protein results in increased degradation of Serotonin]
Phenylpropanolamine inhibits the reaction [Clorgyline results in decreased activity of MAOA protein]
Phenylpropanolamine results in decreased activity of MAOA protein

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

decreases activity
multiple interactions

EXP
ISO

Phenylpropanolamine results in decreased activity of MAOB protein
Phenylpropanolamine inhibits the reaction [MAOB protein results in increased degradation of phenethylamine]

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

membrane-bound transcription factor peptidase, site 1

decreases expression

ISO

Phenylpropanolamine results in decreased expression of MBTPS1 mRNA

NCBI chr19:64,470,245...64,521,438
Ensembl chr19:64,470,545...64,521,342

G

melanocortin 3 receptor

multiple interactions
increases expression

EXP

Enzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in increased expression of MC3R protein]

NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:181,434,776...181,435,873

G

monoglyceride lipase

decreases expression

ISO

Phenylpropanolamine results in decreased expression of MGLL mRNA

NCBI chr 4:122,749,436...122,851,440
Ensembl chr 4:122,749,436...122,851,440

G

methylsterol monooxygenase 1

increases expression

ISO

Phenylpropanolamine results in increased expression of MSMO1 mRNA

NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445

G

mevalonate diphosphate decarboxylase

increases expression

ISO

Phenylpropanolamine results in increased expression of MVD mRNA

NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366

G

mevalonate kinase

increases expression

ISO

Phenylpropanolamine results in increased expression of MVK mRNA

NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503

G

NPC intracellular cholesterol transporter 1

increases expression

ISO

Phenylpropanolamine results in increased expression of NPC1 mRNA

NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,654,237...3,699,800

G

NPC intracellular cholesterol transporter 2

increases expression

ISO

Phenylpropanolamine results in increased expression of NPC2 mRNA

NCBI chr 6:110,128,325...110,149,245
Ensembl chr 6:110,128,325...110,150,004

G

neuropeptide Y

multiple interactions
decreases expression

EXP

[Prazosin co-treated with SCH 23390] inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY protein]; Enzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY protein]; NPY1R protein affects the reaction [Phenylpropanolamine results in decreased expression of NPY protein]; S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in decreased expression of NPY mRNA]
Phenylpropanolamine results in decreased expression of NPY mRNA; Phenylpropanolamine results in decreased expression of NPY protein

PMID:17684035 PMID:21989786 PMID:23052195 PMID:24792324

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

neuropeptide Y receptor Y1

multiple interactions
affects response to substance
increases expression

EXP

NPY1R protein affects the reaction [Phenylpropanolamine results in decreased expression of NPY protein]
NPY1R protein affects the susceptibility to Phenylpropanolamine
Phenylpropanolamine results in increased expression of NPY1R protein

NCBI chr16:27,804,416...27,814,070
Ensembl chr16:27,804,416...27,813,387

G

phosphoglycerate kinase 1

decreases expression

ISO

Phenylpropanolamine results in decreased expression of PGK1 mRNA

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:75,336,687...75,352,959

G

phospholipase C beta 1

increases expression

ISO

Phenylpropanolamine results in increased expression of PLCB1 mRNA

NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646

G

proopiomelanocortin

increases expression
multiple interactions

EXP

Phenylpropanolamine results in increased expression of POMC mRNA; Phenylpropanolamine results in increased expression of POMC protein
S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of POMC mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of POMC mRNA]

PMID:17684035 PMID:24792324

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

protein kinase cAMP-dependent type II regulatory subunit alpha

increases expression

EXP

Phenylpropanolamine results in increased expression of PRKAR2A mRNA; Phenylpropanolamine results in increased expression of PRKAR2A protein

NCBI chr 8:118,271,608...118,337,332
Ensembl chr 8:118,274,167...118,337,330

G

prosaposin

decreases expression

ISO

Phenylpropanolamine results in decreased expression of PSAP mRNA

NCBI chr20:28,756,951...28,783,422
Ensembl chr20:28,757,181...28,783,421

G

RELA proto-oncogene, NF-kB subunit

increases expression

EXP

Phenylpropanolamine results in increased expression of RELA mRNA

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

receptor-interacting serine-threonine kinase 3

increases phosphorylation

ISO

Phenylpropanolamine results in increased phosphorylation of RIPK3 protein

NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025

G

superoxide dismutase 1

multiple interactions
increases expression

EXP

Enzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in increased expression of SOD1 protein]; S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of SOD1 mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of SOD1 mRNA]
Phenylpropanolamine results in increased expression of SOD1 mRNA; Phenylpropanolamine results in increased expression of SOD1 protein

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

increases expression

EXP

Phenylpropanolamine results in increased expression of SOD2 mRNA; Phenylpropanolamine results in increased expression of SOD2 protein

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

squalene epoxidase

increases expression

ISO

Phenylpropanolamine results in increased expression of SQLE mRNA

NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050

G

sterol regulatory element binding transcription factor 2

multiple interactions

ISO

Phenylpropanolamine results in increased cleavage of and results in increased activity of SREBF2 protein

NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943

G

signal transducer and activator of transcription 3

multiple interactions
increases expression
increases activity
increases response to substance

EXP

Enzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in increased expression of STAT3 protein modified form]; S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of STAT3 mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in decreased expression of NPY mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of CAT mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of GSTA1 mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of POMC mRNA]; STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of SOD1 mRNA]
Phenylpropanolamine results in increased expression of STAT3 mRNA; Phenylpropanolamine results in increased expression of STAT3 protein modified form
Phenylpropanolamine results in increased activity of STAT3 protein
STAT3 mRNA results in increased susceptibility to Phenylpropanolamine

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

decreases expression

ISO

Phenylpropanolamine results in decreased expression of SUCLG1 mRNA

NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:106,866,114...106,895,689

G

triosephosphate isomerase 1

decreases expression

ISO

Phenylpropanolamine results in decreased expression of TPI1 mRNA

NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:159,301,562...159,305,413

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

ISO

tetrahydrozoline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
role	20820
application	20621
pharmaceutical	20416
drug	20416
nasal decongestant	578
(-)-ephedrine	28
alpha-methylnoradrenaline	0
garomefrine hydrochloride	0
oxymetazoline	8
oxymetazoline hydrochloride	0
phenylephrine	527
phenylpropanolamine	53
pseudoephedrine	0
tetrahydrozoline hydrochloride	0
tetryzoline	1

paths to the root