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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:olsalazine
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Accession:CHEBI:7770 term browser browse the term
Definition:An azobenzene that consists of two molecules of 4-aminosalicylic acid joined by an azo linkage. A prodrug for mesalazine, an anti-inflammatory drug, it is used (as the disodium salt) in the treatment of inflammatory bowel disease.
Synonyms:exact_synonym: 3,3'-diazene-1,2-diylbis(6-hydroxybenzoic acid)
 related_synonym: 3,3'-Azobis(6-hydroxybenzoic acid);   5,5'-Azobis(salicylic acid);   Formula=C14H10N2O6;   InChI=1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22);   InChIKey=QQBDLJCYGRGAKP-UHFFFAOYSA-N;   Olsalazina;   Olsalazinum;   SMILES=OC(=O)c1cc(ccc1O)N=Nc1ccc(O)c(c1)C(O)=O
 xref: CAS:15722-48-2;   DrugBank:DB01250;   Drug_Central:1988;   KEGG:C07323;   KEGG:D08295
 xref_mesh: MESH:C032587
 xref: Patent:DE278613;   Patent:EP36636;   Patent:US1157169;   Patent:US4528367;   Reaxys:3218651;   Wikipedia:Olsalazine
 cyclic_relationship: is_conjugate_acid_of CHEBI:63719


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olsalazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO olsalazine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pro-agent 11550
          prodrug 11294
            olsalazine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      aromatic carboxylic acid 12689
                                        benzoic acids 12666
                                          benzoic acid 5504
                                            hydroxybenzoic acid 4979
                                              monohydroxybenzoic acid 2814
                                                salicylic acid 1567
                                                  olsalazine 1
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