Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tranilast
go back to main search page
Accession:CHEBI:77572 term browser browse the term
Definition:An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.
Synonyms:exact_synonym: 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid
 related_synonym: Formula=C18H17NO5;   InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+;   InChIKey=NZHGWWWHIYHZNX-CSKARUKUSA-N;   MK-341;   N-(3,4-Dimethoxycinnamoyl)anthranilic acid;   Rizaben;   SMILES=COc1ccc(\\C=C\\C(=O)Nc2ccccc2C(O)=O)cc1OC;   tranilastum
 xref: CAS:53902-12-8;   Drug_Central:2714;   KEGG:D02027
 xref_mesh: MESH:C012293
 xref: PDBeChem:D27;   PMID:22753703;   PMID:23121382;   PMID:23273396;   PMID:23363021;   PMID:23679559;   PMID:23694807;   PMID:23715805;   PMID:23821545;   PMID:23977380;   PMID:24055688;   PMID:24092987;   PMID:24143895;   PMID:24157455;   PMID:24374452;   PMID:24377619;   PMID:24384948;   PMID:24389486;   PMID:24389817;   PMID:24420060;   PMID:24448965;   PMID:24475260;   PMID:24476069;   Reaxys:3085768;   Wikipedia:Tranilast


show annotations for term's descendants           Sort by:
tranilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 decreases expression
multiple interactions
affects expression 		EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery]
tranilast inhibits the reaction [PDGF-BB increases mRNA expression in rat carotid artery smooth muscle cell culture]
tranilast inhibits the reaction [TGF-b1 increases mRNA expression in rat carotid artery smooth muscle cell culture]		 RGD PMID:9622270 PMID:9622270 PMID:9622270 RGD:329845558, RGD:329845558, RGD:329845558 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241 		JBrowse link
G Ahr aryl hydrocarbon receptor increases response to substance
multiple interactions
increases expression		 ISO AHR protein results in increased susceptibility to tranilast
AHR protein promotes the reaction [tranilast results in increased expression of AHR mRNA]; AHR protein promotes the reaction [tranilast results in increased expression of CYP1A1 mRNA]; tranilast promotes the reaction [AHR protein binds to CYP1A1 promoter]		 CTD PMID:25826687 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP tranilast inhibits the reaction [Cisplatin results in increased expression of CASP8 protein] CTD PMID:34047436 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO tranilast results in decreased expression of CXCR4 mRNA CTD PMID:25826687 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO AHR protein promotes the reaction [tranilast results in increased expression of CYP1A1 mRNA]; tranilast promotes the reaction [AHR protein binds to CYP1A1 promoter] CTD PMID:25826687 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects expression ISO tranilast affects the expression of CYP1B1 mRNA CTD PMID:25826687 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO tranilast inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Itgav integrin subunit alpha V decreases expression EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery] RGD PMID:9622270 RGD:329845558 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgb3 integrin subunit beta 3 decreases expression EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery] RGD PMID:9622270 RGD:329845558 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP tranilast inhibits the reaction [Cisplatin results in increased expression of RELA protein] CTD PMID:34047436 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP tranilast inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]; tranilast inhibits the reaction [SLC22A8 protein results in increased uptake of Penicillin G] CTD PMID:35019195 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery] RGD PMID:9622270 RGD:329845558 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery] RGD PMID:9622270 RGD:329845558 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression
multiple interactions
affects expression 		EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery]
tranilast inhibits the reaction [PDGF-BB increases mRNA expression in rat carotid artery smooth muscle cell culture]
tranilast inhibits the reaction [TGF-b1 increases mRNA expression in rat carotid artery smooth muscle cell culture]		 RGD PMID:9622270 PMID:9622270 PMID:9622270 RGD:329845558, RGD:329845558, RGD:329845558 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression
multiple interactions
affects expression 		EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery]
tranilast inhibits the reaction [PDGF-BB increases mRNA expression in rat carotid artery smooth muscle cell culture]
tranilast inhibits the reaction [TGF-b1 increases mRNA expression in rat carotid artery smooth muscle cell culture]		 RGD PMID:9622270 PMID:9622270 PMID:9622270 RGD:329845558, RGD:329845558, RGD:329845558 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP tranilast inhibits the reaction [Cisplatin results in increased expression of TNF protein] CTD PMID:34047436 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions EXP tranilast inhibits the reaction [Cisplatin results in increased expression of TNFSF10 protein] CTD PMID:34047436 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 decreases activity ISO tranilast results in decreased activity of TRPV2 protein CTD PMID:30235802 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        anti-asthmatic agent 9317
          anti-asthmatic drug 8689
            tranilast 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      carboacyl group 17712
                                        univalent carboacyl group 17712
                                          carbamoyl group 17563
                                            carboxamide 17563
                                              alpha,beta-unsaturated carboxylic acid amide 7123
                                                enamide 7123
                                                  cinnamamides 1355
                                                    tranilast 18
paths to the root