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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tranilast
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Accession:CHEBI:77572 term browser browse the term
Definition:An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.
Synonyms:exact_synonym: 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid
 related_synonym: Formula=C18H17NO5;   InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+;   InChIKey=NZHGWWWHIYHZNX-CSKARUKUSA-N;   MK-341;   N-(3,4-Dimethoxycinnamoyl)anthranilic acid;   Rizaben;   SMILES=COc1ccc(\\C=C\\C(=O)Nc2ccccc2C(O)=O)cc1OC;   tranilastum
 xref: CAS:53902-12-8;   Drug_Central:2714;   KEGG:D02027
 xref_mesh: MESH:C012293
 xref: PDBeChem:D27;   PMID:22753703;   PMID:23121382;   PMID:23273396;   PMID:23363021;   PMID:23679559;   PMID:23694807;   PMID:23715805;   PMID:23821545;   PMID:23977380;   PMID:24055688;   PMID:24092987;   PMID:24143895;   PMID:24157455;   PMID:24374452;   PMID:24377619;   PMID:24384948;   PMID:24389486;   PMID:24389817;   PMID:24420060;   PMID:24448965;   PMID:24475260;   PMID:24476069;   Reaxys:3085768;   Wikipedia:Tranilast


show annotations for term's descendants           Sort by:
tranilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 decreases expression
multiple interactions
affects expression 		EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery]
tranilast inhibits the reaction [PDGF-BB increases mRNA expression in rat carotid artery smooth muscle cell culture]
tranilast inhibits the reaction [TGF-b1 increases mRNA expression in rat carotid artery smooth muscle cell culture] 		RGD PMID:9622270 PMID:9622270 PMID:9622270 RGD:329845558, RGD:329845558, RGD:329845558 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:63,387,381...63,477,884 		JBrowse link
G Ahr aryl hydrocarbon receptor increases response to substance
multiple interactions
increases expression 		ISO AHR protein results in increased susceptibility to tranilast
AHR protein promotes the reaction [tranilast results in increased expression of AHR mRNA]; AHR protein promotes the reaction [tranilast results in increased expression of CYP1A1 mRNA]; tranilast promotes the reaction [AHR protein binds to CYP1A1 promoter] 		CTD PMID:25826687 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP tranilast inhibits the reaction [Cisplatin results in increased expression of CASP8 protein] CTD PMID:34047436 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO tranilast results in decreased expression of CXCR4 mRNA CTD PMID:25826687 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression 		ISO AHR protein promotes the reaction [tranilast results in increased expression of CYP1A1 mRNA]; tranilast promotes the reaction [AHR protein binds to CYP1A1 promoter] CTD PMID:25826687 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects expression ISO tranilast affects the expression of CYP1B1 mRNA CTD PMID:25826687 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO tranilast inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Itgav integrin subunit alpha V decreases expression EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery] RGD PMID:9622270 RGD:329845558 NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511 		JBrowse link
G Itgb3 integrin subunit beta 3 decreases expression EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery] RGD PMID:9622270 RGD:329845558 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP tranilast inhibits the reaction [Cisplatin results in increased expression of RELA protein] CTD PMID:34047436 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP tranilast inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]; tranilast inhibits the reaction [SLC22A8 protein results in increased uptake of Penicillin G] CTD PMID:35019195 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery] RGD PMID:9622270 RGD:329845558 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery] RGD PMID:9622270 RGD:329845558 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression
multiple interactions
affects expression 		EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery]
tranilast inhibits the reaction [PDGF-BB increases mRNA expression in rat carotid artery smooth muscle cell culture]
tranilast inhibits the reaction [TGF-b1 increases mRNA expression in rat carotid artery smooth muscle cell culture] 		RGD PMID:9622270 PMID:9622270 PMID:9622270 RGD:329845558, RGD:329845558, RGD:329845558 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression
multiple interactions
affects expression 		EXP tranilast inhibits the reaction [balloon angioplasty increases mRNA expression in rat carotid artery]
tranilast inhibits the reaction [PDGF-BB increases mRNA expression in rat carotid artery smooth muscle cell culture]
tranilast inhibits the reaction [TGF-b1 increases mRNA expression in rat carotid artery smooth muscle cell culture] 		RGD PMID:9622270 PMID:9622270 PMID:9622270 RGD:329845558, RGD:329845558, RGD:329845558 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP tranilast inhibits the reaction [Cisplatin results in increased expression of TNF protein] CTD PMID:34047436 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions EXP tranilast inhibits the reaction [Cisplatin results in increased expression of TNFSF10 protein] CTD PMID:34047436 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 decreases activity ISO tranilast results in decreased activity of TRPV2 protein CTD PMID:30235802 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,764,839...47,793,533 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        anti-asthmatic agent 9361
          anti-asthmatic drug 8705
            tranilast 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              alpha,beta-unsaturated carboxylic acid amide 7298
                                                enamide 7298
                                                  cinnamamides 1355
                                                    tranilast 18
paths to the root