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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,3,7,8-tetrabromodibenzodioxine
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Accession:CHEBI:77565 term browser browse the term
Definition:An organobromine compound that is dibenzodioxine carrying four bromo substituents at positions 2, 3, 7 and 8.
Synonyms:exact_synonym: 2,3,7,8-tetrabromooxanthrene
 related_synonym: 2,3,7,8-TBDD;   2,3,7,8-Tetrabromodibenzo-4-dioxin;   2,3,7,8-Tetrabromodibenzo-p-dioxin;   2,3,7,8-Tetrabromodibenzodioxin;   Formula=C12H4Br4O2;   InChI=1S/C12H4Br4O2/c13-5-1-9-10(2-6(5)14)18-12-4-8(16)7(15)3-11(12)17-9/h1-4H;   InChIKey=JZLQUWSWOJPCAK-UHFFFAOYSA-N;   SMILES=Brc1cc2Oc3cc(Br)c(Br)cc3Oc2cc1Br
 xref: CAS:50585-41-6
 xref_mesh: MESH:C066841
 xref: PMID:1494962;   PMID:19660807;   PMID:8484261;   Reaxys:273317


show annotations for term's descendants           Sort by:
2,3,7,8-tetrabromodibenzodioxine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acad8 acyl-CoA dehydrogenase family, member 8 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ACAD8 protein CTD PMID:27604104 NCBI chr 8:25,382,271...25,406,404
Ensembl chr 8:25,382,273...25,406,414 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of ACADM protein CTD PMID:27604104 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Aco2 aconitase 2 decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of ACO2 protein CTD PMID:27604104 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of ADH1 protein CTD PMID:27604104 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Ahcy adenosylhomocysteinase increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of AHCY protein CTD PMID:27604104 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity		 EXP
ISO		 2,3,7,8-tetrabromodibenzo-4-dioxin binds to and results in increased activity of AHR protein
2,3,7,8-tetrabromodibenzo-4-dioxin results in increased activity of AHR protein		 CTD PMID:12850102 PMID:15099731 PMID:28669845 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Alad aminolevulinate dehydratase increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ALAD protein CTD PMID:27604104 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ALDH1L1 protein CTD PMID:27604104 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ALDH2 protein CTD PMID:27604104 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of ALDH4A1 protein CTD PMID:27604104 NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345 		JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ALDH7A1 protein CTD PMID:27604104 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193 		JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ALDH8A1 protein CTD PMID:27604104 NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of ALDOB protein CTD PMID:27604104 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Arg1 arginase 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ARG1 protein CTD PMID:27604104 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Ass1 argininosuccinate synthase 1 affects expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin affects the expression of ASS1 protein CTD PMID:27604104 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of BCKDHA protein CTD PMID:27604104 NCBI chr 1:81,138,946...81,167,765
Ensembl chr 1:81,138,947...81,167,862 		JBrowse link
G Cat catalase decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of CAT protein CTD PMID:27604104 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cc2d1b coiled-coil and C2 domain containing 1B decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of CC2D1B protein CTD PMID:27604104 NCBI chr 5:123,353,289...123,367,343
Ensembl chr 5:123,353,292...123,367,318 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of CPS1 protein CTD PMID:27604104 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033 		JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of CTH protein CTD PMID:27604104 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Cyb5a cytochrome b5 type A increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of CYB5A protein CTD PMID:27604104 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of CYP11A1 mRNA CTD PMID:17447562 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of CYP11B2 mRNA CTD PMID:17447562 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of CYP17A1 mRNA CTD PMID:17447562 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of and results in increased activity of CYP1A1 protein CTD PMID:27604104 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of and results in increased activity of CYP1A2 protein CTD PMID:27604104 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of DNAJB11 protein CTD PMID:27604104 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407 		JBrowse link
G Dpys dihydropyrimidinase increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of DPYS protein CTD PMID:27604104 NCBI chr 7:70,822,648...70,929,255
Ensembl chr 7:70,835,789...70,929,231 		JBrowse link
G Eno1 enolase 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ENO1 protein CTD PMID:27604104 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336 		JBrowse link
G Ephx2 epoxide hydrolase 2 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of EPHX2 protein CTD PMID:27604104 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Fbp1 fructose-bisphosphatase 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of FBP1 protein CTD PMID:27604104 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071 		JBrowse link
G Glud1 glutamate dehydrogenase 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of GLUD1 protein CTD PMID:27604104 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957 		JBrowse link
G Glul glutamate-ammonia ligase decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of GLUL mRNA CTD PMID:27604104 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression
decreases expression		 ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of GOT1 protein
2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of GOT1 mRNA		 CTD PMID:27604104 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gprin1 G protein-regulated inducer of neurite outgrowth 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of GPRIN1 protein CTD PMID:27604104 NCBI chr17:9,863,881...9,876,832
Ensembl chr17:9,863,571...9,876,915 		JBrowse link
G Gstz1 glutathione S-transferase zeta 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of GSTZ1 protein CTD PMID:27604104 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284 		JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of HAAO protein CTD PMID:27604104 NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877 		JBrowse link
G Hacl1 2-hydroxyacyl-CoA lyase 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of HACL1 protein CTD PMID:27604104 NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027 		JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of HPD protein CTD PMID:27604104 NCBI chr12:33,381,397...33,392,750
Ensembl chr12:33,381,231...33,392,766 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of HSD17B4 mRNA CTD PMID:17447562 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of HSD3B2 mRNA CTD PMID:17447562 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Il5 interleukin 5 decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of IL5 protein CTD PMID:19041680 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Inmt indolethylamine N-methyltransferase increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of INMT protein CTD PMID:27604104 NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493 		JBrowse link
G Mccc2 methylcrotonyl-CoA carboxylase subunit 2 decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of MCCC2 protein CTD PMID:27604104 NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972 		JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of MDH1 protein CTD PMID:27604104 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Pc pyruvate carboxylase increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of PC protein CTD PMID:27604104 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Pcca propionyl-CoA carboxylase subunit alpha increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of PCCA protein CTD PMID:27604104 NCBI chr15:99,627,955...99,969,555
Ensembl chr15:99,627,982...99,968,266 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 affects expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin affects the expression of PDHA1 protein CTD PMID:27604104 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pm20d1 peptidase M20 domain containing 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of PM20D1 protein CTD PMID:27604104 NCBI chr13:43,237,954...43,259,999
Ensembl chr13:43,237,971...43,259,999 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of PRDX1 protein CTD PMID:27604104 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Psma1 proteasome 20S subunit alpha 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of PSMA1 protein CTD PMID:27604104 NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472 		JBrowse link
G Psma6 proteasome 20S subunit alpha 6 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of PSMA6 protein CTD PMID:27604104 NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of SHMT1 protein CTD PMID:27604104 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of SOD1 protein CTD PMID:27604104 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sord sorbitol dehydrogenase increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of SORD protein CTD PMID:27604104 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133 		JBrowse link
G Tf transferrin increases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of TF protein CTD PMID:27604104 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tlk1 tousled-like kinase 1 decreases expression ISO 2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of TLK1 protein CTD PMID:27604104 NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        xenobiotic 18728
          dibenzodioxine 15170
            2,3,7,8-tetrabromodibenzodioxine 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterotricyclic compound 15845
                                      dibenzodioxine 15170
                                        2,3,7,8-tetrabromodibenzodioxine 57
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