|
G
|
Acta2
|
actin alpha 2, smooth muscle
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
|
CTD |
PMID:16757516 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
|
|
G
|
Adam9
|
ADAM metallopeptidase domain 9
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein]
|
CTD |
PMID:17018608 |
|
NCBI chr16:73,725,186...73,804,284
Ensembl chr16:73,725,114...73,804,646
|
|
G
|
Afp
|
alpha-fetoprotein
|
multiple interactions
|
EXP
|
ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA]
|
CTD |
PMID:11133813 |
|
NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649
|
|
G
|
Alad
|
aminolevulinate dehydratase
|
multiple interactions decreases activity
|
EXP ISO
|
Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein] ebselen inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]
|
CTD |
PMID:14630126 PMID:17624921 PMID:23933410 |
|
NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041
|
|
G
|
Alox5
|
arachidonate 5-lipoxygenase
|
decreases activity
|
ISO
|
ebselen results in decreased activity of ALOX5 protein
|
CTD |
PMID:7590103 |
|
NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions
|
EXP
|
ebselen inhibits the reaction [sodium arsenite results in increased expression of BAX protein]
|
CTD |
PMID:30558456 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions
|
EXP
|
ebselen inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]
|
CTD |
PMID:30558456 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions increases activity
|
ISO EXP
|
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP3 protein] ebselen inhibits the reaction [Methylmercury Compounds results in increased activity of CASP3 protein]; ebselen inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein] ebselen results in increased activity of CASP3 protein
|
CTD |
PMID:21300091 PMID:23649643 PMID:25068500 PMID:30558456 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp9
|
caspase 9
|
multiple interactions
|
ISO EXP
|
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP9 protein] ebselen inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein]
|
CTD |
PMID:18629305 PMID:23649643 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Cat
|
catalase
|
increases activity multiple interactions
|
EXP
|
ebselen results in increased activity of CAT protein ebselen inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
|
CTD |
PMID:27282967 PMID:30558456 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Cox4i1
|
cytochrome c oxidase subunit 4i1
|
increases expression
|
ISO
|
ebselen results in increased expression of COX4I1 protein
|
CTD |
PMID:27385396 |
|
NCBI chr19:65,630,383...65,636,623
Ensembl chr19:65,630,432...65,636,624
|
|
G
|
Cs
|
citrate synthase
|
multiple interactions
|
ISO EXP
|
ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein] ebselen inhibits the reaction [Cisplatin results in decreased activity of CS protein]
|
CTD |
PMID:27385396 PMID:32860823 |
|
NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938
|
|
G
|
Cyp2e1
|
cytochrome P450, family 2, subfamily e, polypeptide 1
|
multiple interactions
|
EXP
|
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]
|
CTD |
PMID:11903743 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
|
|
G
|
Eif2s1
|
eukaryotic translation initiation factor 2 subunit alpha
|
increases phosphorylation
|
EXP
|
ebselen results in increased phosphorylation of EIF2S1 protein
|
CTD |
PMID:27282967 |
|
NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649
|
|
G
|
Ephx2
|
epoxide hydrolase 2
|
multiple interactions
|
ISO
|
ebselen binds to and results in decreased activity of EPHX2 protein
|
CTD |
PMID:23219563 |
|
NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160
|
|
G
|
Fmr1
|
fragile X messenger ribonucleoprotein 1
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]
|
CTD |
PMID:27385396 |
|
NCBI chr X:152,284,857...152,322,686
Ensembl chr X:152,284,841...152,322,675
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]
|
CTD |
PMID:14572605 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
|
|
G
|
G6pc1
|
glucose-6-phosphatase catalytic subunit 1
|
multiple interactions
|
EXP
|
ebselen inhibits the reaction [Cisplatin results in increased activity of G6PC1 protein]
|
CTD |
PMID:32860823 |
|
NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033
|
|
G
|
Gck
|
glucokinase
|
multiple interactions
|
ISO
|
[ebselen co-treated with Glucose] results in increased activity of GCK protein
|
CTD |
PMID:23795780 |
|
NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949
|
|
G
|
Gfap
|
glial fibrillary acidic protein
|
increases phosphorylation
|
EXP
|
ebselen results in increased phosphorylation of GFAP protein
|
CTD |
PMID:27282967 |
|
NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
|
|
G
|
Gja1
|
gap junction protein, alpha 1
|
multiple interactions
|
EXP
|
ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]; ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein]
|
CTD |
PMID:12958040 |
|
NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689
|
|
G
|
Gpx1
|
glutathione peroxidase 1
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]] ebselen inhibits the reaction [Methylmercury Compounds results in decreased activity of GPX1 protein]
|
CTD |
PMID:23795780 PMID:28383113 |
|
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
|
|
G
|
Gsr
|
glutathione-disulfide reductase
|
increases activity multiple interactions
|
EXP
|
ebselen results in increased activity of GSR protein ebselen inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]
|
CTD |
PMID:27282967 PMID:30558456 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
|
|
G
|
Gsta1
|
glutathione S-transferase alpha 1
|
multiple interactions
|
EXP
|
ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein]
|
CTD |
PMID:8147899 |
|
NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528
|
|
G
|
Gsta3
|
glutathione S-transferase alpha 3
|
multiple interactions
|
EXP
|
ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein]; ebselen binds to and results in decreased activity of GSTA3 protein
|
CTD |
PMID:8147899 |
|
NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654
|
|
G
|
Gstm1
|
glutathione S-transferase mu 1
|
multiple interactions
|
EXP
|
ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein]
|
CTD |
PMID:8147899 |
|
NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569
|
|
G
|
Gstm2
|
glutathione S-transferase mu 2
|
multiple interactions
|
EXP
|
ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein]
|
CTD |
PMID:8147899 |
|
NCBI chr 2:198,312,179...198,316,962
|
|
G
|
Gstp1
|
glutathione S-transferase pi 1
|
multiple interactions
|
EXP
|
ebselen binds to and results in decreased activity of GSTP1 protein
|
CTD |
PMID:8147899 |
|
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
|
|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]
|
CTD |
PMID:19374849 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions
|
EXP
|
[ebselen affects the abundance of Reactive Oxygen Species] which results in decreased expression of HMOX1 protein; [ebselen affects the abundance of Reactive Oxygen Species] which results in increased activity of HMOX1 protein
|
CTD |
PMID:16959961 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
|
|
G
|
Hpgds
|
hematopoietic prostaglandin D synthase
|
increases expression
|
ISO
|
ebselen results in increased expression of HPGDS mRNA
|
CTD |
PMID:21669866 |
|
NCBI chr 4:95,698,265...95,727,733
Ensembl chr 4:95,702,392...95,938,501
|
|
G
|
Hsf1
|
heat shock transcription factor 1
|
increases activity
|
ISO
|
ebselen results in increased activity of HSF1 protein
|
CTD |
PMID:34170685 |
|
NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665
|
|
G
|
Ifng
|
interferon gamma
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
|
CTD |
PMID:12794164 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
EXP
|
ebselen inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]
|
CTD |
PMID:30558456 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Ins1
|
insulin 1
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen promotes the reaction [Glucose results in increased secretion of INS1 protein]
|
CTD |
PMID:23795780 |
|
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions increases phosphorylation increases activity
|
ISO EXP
|
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] ebselen analog results in increased phosphorylation of MAPK1 protein; ebselen results in increased phosphorylation of MAPK1 protein ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK1 protein] ebselen results in increased activity of MAPK1 protein
|
CTD |
PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions increases phosphorylation increases activity
|
ISO EXP
|
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK3 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK3 protein] ebselen analog results in increased phosphorylation of MAPK3 protein; ebselen results in increased phosphorylation of MAPK3 protein ebselen results in increased activity of MAPK3 protein
|
CTD |
PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mapk9
|
mitogen-activated protein kinase 9
|
increases phosphorylation
|
EXP
|
ebselen results in increased phosphorylation of MAPK9 protein
|
CTD |
PMID:27282967 |
|
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
|
|
G
|
Mmp13
|
matrix metallopeptidase 13
|
multiple interactions
|
EXP
|
ebselen inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]
|
CTD |
PMID:11903743 |
|
NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105
|
|
G
|
Ngf
|
nerve growth factor
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
|
CTD |
PMID:20495008 |
|
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions decreases activity
|
ISO EXP
|
ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] ebselen results in decreased activity of NOS2 protein
|
CTD |
PMID:7590103 PMID:12794164 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
G
|
Nqo1
|
NAD(P)H quinone dehydrogenase 1
|
decreases activity
|
EXP
|
ebselen results in decreased activity of NQO1 protein
|
CTD |
PMID:7590103 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
|
|
G
|
Pdx1
|
pancreatic and duodenal homeobox 1
|
multiple interactions
|
ISO
|
[ebselen co-treated with Glucose] results in increased expression of PDX1 protein
|
CTD |
PMID:23795780 |
|
NCBI chr12:12,793,957...12,799,156
Ensembl chr12:12,793,957...12,799,156
|
|
G
|
Phospho1
|
phosphoethanolamine/phosphocholine phosphatase 1
|
decreases activity
|
ISO
|
ebselen results in decreased activity of PHOSPHO1 protein
|
CTD |
PMID:17227223 |
|
NCBI chr10:81,258,810...81,266,345
Ensembl chr10:81,257,427...81,268,481
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]
|
CTD |
PMID:14572605 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
|
|
G
|
Slc11a2
|
solute carrier family 11 member 2
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]
|
CTD |
PMID:16984886 |
|
NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941
|
|
G
|
Slc2a2
|
solute carrier family 2 member 2
|
multiple interactions
|
ISO EXP
|
[ebselen co-treated with Glucose] results in increased expression of SLC2A2 protein ebselen inhibits the reaction [Cisplatin results in increased expression of SLC2A2 protein]
|
CTD |
PMID:23795780 PMID:32860823 |
|
NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467
|
|
G
|
Smad3
|
SMAD family member 3
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
|
CTD |
PMID:21131394 |
|
NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324
|
|
G
|
Sod1
|
superoxide dismutase 1
|
decreases response to substance multiple interactions
|
ISO
|
ebselen results in decreased susceptibility to SOD1 protein mutant form ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
|
CTD |
PMID:16702190 PMID:23795780 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
|
|
G
|
Sod2
|
superoxide dismutase 2
|
multiple interactions
|
EXP
|
ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
|
CTD |
PMID:20495008 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
|
|
G
|
Tat
|
tyrosine aminotransferase
|
multiple interactions
|
EXP
|
ebselen inhibits the reaction [Cisplatin results in increased activity of TAT protein]
|
CTD |
PMID:32860823 |
|
NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482
|
|
G
|
Tgfb1
|
transforming growth factor, beta 1
|
multiple interactions
|
EXP ISO
|
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
|
CTD |
PMID:11903743 PMID:16757516 PMID:21131394 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
|
|
G
|
Timp1
|
TIMP metallopeptidase inhibitor 1
|
multiple interactions
|
EXP
|
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]
|
CTD |
PMID:11903743 |
|
NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
EXP
|
ebselen inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
|
CTD |
PMID:30558456 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
G
|
Txnrd1
|
thioredoxin reductase 1
|
multiple interactions
|
ISO
|
ebselen results in increased expression of and results in increased activity of TXNRD1 protein
|
CTD |
PMID:28383113 |
|
NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817
|
|
G
|
Ucp2
|
uncoupling protein 2
|
multiple interactions
|
ISO
|
[ebselen co-treated with Glucose] results in decreased expression of UCP2 protein
|
CTD |
PMID:23795780 |
|
NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743
|
|
G
|
Xbp1
|
X-box binding protein 1
|
increases phosphorylation
|
EXP
|
ebselen results in increased phosphorylation of XBP1 protein
|
CTD |
PMID:27282967 |
|
NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706
|
|
G
|
Xpa
|
XPA, DNA damage recognition and repair factor
|
multiple interactions
|
ISO
|
ebselen inhibits the reaction [Zinc binds to XPA protein]
|
CTD |
PMID:15265038 |
|
NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:65,227,281...65,272,425
|
|