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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ginsenoside C-K
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Accession:CHEBI:77146 term browser browse the term
Definition:A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.
Synonyms:exact_synonym: (3beta,12beta)-3,12-dihydroxydammar-24-en-20-yl beta-D-glucopyranoside
 related_synonym: (20S)-ginsenoside C-K;   20beta-(beta-D-glucopyranosyloxy)dammar-24-ene-3beta,12beta-diol;   Formula=C36H62O8;   InChI=1S/C36H62O8/c1-20(2)10-9-14-36(8,44-31-30(42)29(41)28(40)23(19-37)43-31)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(39)32(3,4)24(33)12-17-34(25,35)6/h10,21-31,37-42H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26-,27-,28+,29-,30+,31-,33-,34+,35+,36-/m0/s1;   InChIKey=FVIZARNDLVOMSU-IRFFNABBSA-N;   SMILES=CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C;   ginsenoside compound K
 alt_id: MESH:C112772
 xref_mesh: MESH:C112772
 xref: MetaCyc:CPD-15450;   PMID:16931427;   PMID:17268094;   PMID:18050731;   PMID:18179546;   PMID:19202288;   PMID:20969919;   PMID:20979019;   PMID:21586309;   PMID:22007540;   PMID:22426808;   PMID:23013417;   PMID:23254888;   PMID:23370854;   PMID:23497352;   PMID:23774035;   PMID:24117771;   Patent:KR20110057895;   Patent:KR20110073699;   Patent:KR20110087900;   Patent:KR20110113228;   Patent:US2011212909;   Patent:WO2008034328;   Patent:WO2010045787;   Reaxys:5785005


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ginsenoside C-K term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions ISO ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of CXCR1 protein] CTD PMID:21875580 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:83,215,292...83,226,872 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:21875580 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma decreases expression ISO ginsenoside compound K results in decreased expression of IFNG mRNA CTD PMID:15914323 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO ginsenoside compound K results in decreased expression of IL1B mRNA CTD PMID:15914323 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 decreases expression ISO ginsenoside compound K results in decreased expression of IL4 mRNA CTD PMID:15914323 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside compound K inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Itga4 integrin subunit alpha 4 multiple interactions ISO ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039 		JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,058,492...11,097,182 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases secretion ISO ginsenoside compound K results in decreased secretion of MMP9 protein CTD PMID:21875580 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP ginsenoside compound K results in decreased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15802804 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP ginsenoside compound K results in decreased expression of and results in decreased activity of NOS2 protein CTD PMID:15802804 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions ISO [ginsenoside compound K co-treated with Adenosine Triphosphate] results in increased activity of P2RX4 protein; ginsenoside compound K promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] CTD PMID:30545933 NCBI chr12:39,505,438...39,523,349
Ensembl chr12:39,505,438...39,523,094 		JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases response to substance ISO P2RX7 gene mutant form results in decreased susceptibility to ginsenoside compound K CTD PMID:30545933 NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO
EXP 		ginsenoside compound K results in decreased expression of PTGS2 mRNA
ginsenoside compound K results in decreased expression of PTGS2 protein 		CTD PMID:15802804 PMID:15914323 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP ginsenoside compound K results in decreased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15802804 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sele selectin E multiple interactions ISO ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:21875580 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
decreases expression 		ISO ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]; ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]; ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of CXCR1 protein]; ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; ginsenoside compound K inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
ginsenoside compound K results in decreased susceptibility to TNF protein
ginsenoside compound K results in decreased expression of TNF mRNA 		CTD PMID:15914323 PMID:21875580 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO ginsenoside compound K inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:21875580 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        anti-inflammatory agent 16834
          ginsenoside C-K 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbohydrates and carbohydrate derivatives 15487
                                    carbohydrate 15487
                                      monosaccharide 5123
                                        aldose 3497
                                          aldohexose 3156
                                            glucose 3109
                                              D-glucose 3107
                                                D-glucopyranose 1828
                                                  beta-D-glucose 1672
                                                    beta-D-glucoside 1479
                                                      ginsenoside C-K 20
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