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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide
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Accession:CHEBI:77054 term browser browse the term
Definition:An aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively.
Synonyms:xref: VSDB:1809;   lincs.smallmolecule:LSM-4989
 chemrof_formula: C22H14Cl2I2N2O2
 chemrof_smiles: Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O
 chemrof_inchi: InChI=1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)
 chemrof_inchikey: JMPFSEBWVLAJKM-UHFFFAOYSA-N


show annotations for term's descendants           Sort by:
closantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions 		ISO ABCB1A protein results in decreased susceptibility to closantel
closantel results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes] 		CTD PMID:20513441 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression EXP closantel results in increased expression of BCL3 mRNA CTD PMID:22015988 NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:88,599,321...88,614,368 		JBrowse link
G Slc25a31 solute carrier family 25 member 31 decreases activity ISO closantel results in decreased activity of SLC25A31 protein CTD PMID:26746582 NCBI chr 2:125,623,331...125,639,155
Ensembl chr 2:125,623,341...125,654,376 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 decreases activity ISO closantel results in decreased activity of SLC25A4 protein CTD PMID:26746582 NCBI chr16:52,805,521...52,809,316
Ensembl chr16:52,805,523...52,811,700 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 decreases activity ISO closantel results in decreased activity of SLC25A5 protein CTD PMID:26746582 NCBI chr  X:120,897,616...120,900,683
Ensembl chr  X:120,897,563...120,900,688 		JBrowse link
G Slc25a5-ps11 solute carrier family 25 member 5, pseudogene 11 decreases activity ISO closantel results in decreased activity of SLC25A6 protein CTD PMID:26746582 NCBI chr18:70,846,358...70,847,597
Ensembl chr18:70,846,358...70,847,597 		JBrowse link
G Thra thyroid hormone receptor alpha increases activity EXP closantel results in increased activity of THRA protein CTD PMID:22015988 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657 		JBrowse link
G Thrb thyroid hormone receptor beta increases activity EXP closantel results in increased activity of THRB protein CTD PMID:22015988 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      group 20774
        pseudohalo group 4800
          cyano group 4798
            nitrile 4798
              N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide 8
                (R)-closantel + 8
                (S)-closantel + 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                carbocyclic compound 18739
                                  benzenoid aromatic compound 17899
                                    benzenes 17656
                                      chlorobenzenes 15281
                                        monochlorobenzenes 12256
                                          N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide 8
                                            (R)-closantel + 8
                                            (S)-closantel + 8
paths to the root