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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:closantel
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Accession:CHEBI:77053 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-clostanel. An anthelmintic, it is used (as the dihydrate of the sodium salt) in veterinary medicine for the treatment of fluke and nematode infections.
Synonyms:exact_synonym: rac-N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide
 related_synonym: 5'-chloro-alpha(4)-(p-chlorophenyl)-alpha(4)-cyano-3,5-diiodo-2',4'-salicyloxylidide;   Flukiver;   R 31,520;   R 31520;   Seponver;   closantelum
 xref: CAS:57808-65-8;   KEGG:D03567
 xref_mesh: MESH:C023342
 xref: PMID:21247019;   PMID:22916226;   PMID:23992251;   PMID:3330516;   PMID:4054009;   PMID:7119989;   PMID:7571353;   PMID:9138034;   Patent:BE839481;   Patent:US4005218;   Reaxys:6249214



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closantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions
ISO ABCB1A protein results in decreased susceptibility to closantel
closantel results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
CTD PMID:20513441 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression EXP closantel results in increased expression of BCL3 mRNA CTD PMID:22015988 NCBI chr 1:79,471,368...79,485,908 JBrowse link
G Slc25a31 solute carrier family 25 member 31 decreases activity ISO closantel results in decreased activity of SLC25A31 protein CTD PMID:26746582 NCBI chr 2:123,695,387...123,711,275 JBrowse link
G Slc25a4 solute carrier family 25 member 4 decreases activity ISO closantel results in decreased activity of SLC25A4 protein CTD PMID:26746582 NCBI chr16:46,072,935...46,076,730 JBrowse link
G Slc25a5 solute carrier family 25 member 5 decreases activity ISO closantel results in decreased activity of SLC25A5 protein CTD PMID:26746582 NCBI chr  X:120,897,616...120,900,683 JBrowse link
G Slc25a5-ps11 solute carrier family 25 member 5, pseudogene 11 decreases activity ISO closantel results in decreased activity of SLC25A6 protein CTD PMID:26746582 NCBI chr18:68,571,222...68,572,461 JBrowse link
G Thra thyroid hormone receptor alpha increases activity EXP closantel results in increased activity of THRA protein CTD PMID:22015988 NCBI chr10:84,198,141...84,225,659 JBrowse link
G Thrb thyroid hormone receptor beta increases activity EXP closantel results in increased activity of THRB protein CTD PMID:22015988 NCBI chr15:10,115,954...10,465,231 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      chemical substance 14414
        mixture 13729
          racemate 12108
            closantel 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      carboacyl group 17726
                                        univalent carboacyl group 17726
                                          carbamoyl group 17570
                                            carboxamide 17570
                                              monocarboxylic acid amide 15746
                                                N-\{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl\}-2-hydroxy-3,5-diiodobenzamide 8
                                                  (R)-closantel 8
                                                    closantel 8
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