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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bromhexine
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Accession:CHEBI:77032 term browser browse the term
Definition:A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).
Synonyms:exact_synonym: 2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline
 related_synonym: 3,5-dibromo-N(alpha)-cyclohexyl-N(alpha)-methyltoluene-alpha-2-diamine;   Fluibron;   Formula=C14H20Br2N2;   InChI=1S/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3;   InChIKey=OJGDCBLYJGHCIH-UHFFFAOYSA-N;   N-cyclohexyl-N-methyl-(2-amino-3,5-dibrombenzyl)amine;   SMILES=CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1;   bromhexina;   bromhexinum
 xref: Beilstein:2216008;   CAS:3572-43-8;   Drug_Central:402;   KEGG:D07542;   LINCS:LSM-3048
 xref_mesh: MESH:D001964
 xref: PMID:20031363;   PMID:22027391;   PMID:23781460;   PMID:4065592;   PMID:7027431;   PMID:7027873;   PMID:778563;   Patent:BE625022;   Wikipedia:Bromhexine
 cyclic_relationship: is_conjugate_base_of CHEBI:77040


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bromhexine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Bromhexine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bromhexine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            mucolytic 982
              bromhexine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        aromatic amine 15478
                                          anilines 14416
                                            substituted aniline 14046
                                              bromhexine 2
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