|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
[Gemcitabine co-treated with licoricidin] results in decreased phosphorylation of AKT1 protein; [licoricidin co-treated with Gemcitabine] results in decreased phosphorylation of AKT1 protein licoricidin results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:29782821 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
licoricidin promotes the reaction [Gemcitabine results in increased activity of CASP3 protein]; licoricidin promotes the reaction [Gemcitabine results in increased expression of and results in increased activity of CASP3 protein]; licoricidin results in increased expression of and results in increased activity of CASP3 protein licoricidin results in increased activity of CASP3 protein |
CTD |
PMID:29782821 PMID:37013980 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
increases activity |
ISO |
licoricidin results in increased activity of CASP9 protein |
CTD |
PMID:37013980 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
licoricidin results in increased expression of DDIT3 mRNA; licoricidin results in increased expression of DDIT3 protein |
CTD |
PMID:37013980 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
|
|
G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
increases expression |
ISO |
licoricidin results in increased expression of ERN1 mRNA; licoricidin results in increased expression of ERN1 protein |
CTD |
PMID:37013980 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
|
|
G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
ISO |
licoricidin results in decreased expression of and affects the localization of HMGB1 protein |
CTD |
PMID:37013980 |
|
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
licoricidin results in increased expression of HSPA5 mRNA; licoricidin results in increased expression of HSPA5 protein |
CTD |
PMID:37013980 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
licoricidin results in increased cleavage of PARP1 protein |
CTD |
PMID:37013980 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases phosphorylation |
ISO |
licoricidin inhibits the reaction [Gemcitabine results in increased phosphorylation of RELA protein] licoricidin results in decreased phosphorylation of RELA protein |
CTD |
PMID:29782821 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|