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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methoxyisoflavan
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Accession:CHEBI:77002 term browser browse the term
Definition:Any member of the class of isoflavans in which one or more ring hydrogens are replaced by methoxy groups.
Synonyms:related_synonym: methoxyisoflavans



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licoricidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO [Gemcitabine co-treated with licoricidin] results in decreased phosphorylation of AKT1 protein; [licoricidin co-treated with Gemcitabine] results in decreased phosphorylation of AKT1 protein
licoricidin results in decreased phosphorylation of AKT1 protein
CTD PMID:29782821 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO licoricidin promotes the reaction [Gemcitabine results in increased activity of CASP3 protein]; licoricidin promotes the reaction [Gemcitabine results in increased expression of and results in increased activity of CASP3 protein]; licoricidin results in increased expression of and results in increased activity of CASP3 protein
licoricidin results in increased activity of CASP3 protein
CTD PMID:29782821 PMID:37013980 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity ISO licoricidin results in increased activity of CASP9 protein CTD PMID:37013980 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO licoricidin results in increased expression of DDIT3 mRNA; licoricidin results in increased expression of DDIT3 protein CTD PMID:37013980 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO licoricidin results in increased expression of ERN1 mRNA; licoricidin results in increased expression of ERN1 protein CTD PMID:37013980 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO licoricidin results in decreased expression of and affects the localization of HMGB1 protein CTD PMID:37013980 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO licoricidin results in increased expression of HSPA5 mRNA; licoricidin results in increased expression of HSPA5 protein CTD PMID:37013980 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO licoricidin results in increased cleavage of PARP1 protein CTD PMID:37013980 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
ISO licoricidin inhibits the reaction [Gemcitabine results in increased phosphorylation of RELA protein]
licoricidin results in decreased phosphorylation of RELA protein
CTD PMID:29782821 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19915
    chemical entity 19913
      atom 19895
        nonmetal atom 19817
          oxygen atom 19555
            oxygen molecular entity 19574
              organooxygen compound 19218
                ether 17325
                  methoxyisoflavan 9
                    (-)-sativan 0
                    (-)-vestitol 0
                    (3R)-7,2'-dihydroxy-3',4'-dimethoxyisoflavan-7-O-beta-D-glucopyranoside 0
                    (3R)-7,2'-dihydroxy-4'-methoxyisoflavanol + 0
                    (3S,4R)-4' hydroxy-6,3' dimethoxyisoflavan-4-ol 0
                    2'-O-methylphaseollinisoflavan 0
                    4',7-dimethoxy-2,2,4-trimethyl-Delta(3)-isoflavan 0
                    7,2'-dihydroxy-4'-methoxyisoflavanol + 0
                    conferol B 0
                    glyasperin C 0
                    glyasperin D 0
                    licoricidin + 9
                    licorisoflavan A 0
                    lotisoflavan 0
                    mucronulatol 0
                    torvanol A hydrogen sulfate 0
                    vestitol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19915
    subatomic particle 19913
      composite particle 19895
        hadron 19895
          baryon 19913
            nucleon 19895
              atomic nucleus 19913
                atom 19895
                  main group element atom 19852
                    p-block element atom 19834
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19722
                              organic cyclic compound 19529
                                organic heterocyclic compound 18893
                                  oxacycle 17920
                                    benzopyran 11970
                                      1-benzopyran 11739
                                        isoflavonoid 3827
                                          isoflavans 136
                                            methoxyisoflavan 9
                                              (-)-sativan 0
                                              (-)-vestitol 0
                                              (3R)-7,2'-dihydroxy-3',4'-dimethoxyisoflavan-7-O-beta-D-glucopyranoside 0
                                              (3R)-7,2'-dihydroxy-4'-methoxyisoflavanol + 0
                                              (3S,4R)-4' hydroxy-6,3' dimethoxyisoflavan-4-ol 0
                                              2'-O-methylphaseollinisoflavan 0
                                              4',7-dimethoxy-2,2,4-trimethyl-Delta(3)-isoflavan 0
                                              7,2'-dihydroxy-4'-methoxyisoflavanol + 0
                                              conferol B 0
                                              glyasperin C 0
                                              glyasperin D 0
                                              licoricidin + 9
                                              licorisoflavan A 0
                                              lotisoflavan 0
                                              mucronulatol 0
                                              torvanol A hydrogen sulfate 0
                                              vestitol + 0
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