mycoestrogen - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	mycoestrogen	go back to main search page
Accession:	CHEBI:76990	browse the term
Definition:	Any compound produced by a fungus that happens to have estrogenic activity.
Synonyms:	related_synonym:	mycoestrogens
	xref:	PMID:17291736; PMID:21392782; Wikipedia:Mycoestrogen

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Rat (736) Mouse (743) Human (762) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (269) Green Monkey (0) Naked Mole-rat (0) All
Genes (736)

zearalenone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

decreases expression

Zearalenone results in decreased expression of AARS1 protein

PMID:25058043 PMID:36252740

NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases expression
decreases expression
affects expression

fulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCB1A mRNA]
Zearalenone results in increased expression of ABCB1 mRNA; Zearalenone results in increased expression of ABCB1A mRNA
Zearalenone results in decreased expression of ABCB1A mRNA
Zearalenone affects the expression of ABCB1A protein

PMID:20607812 PMID:22521637 PMID:23707492 PMID:29627501

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

decreases expression
increases expression

Zearalenone results in decreased expression of ABCB1B mRNA
Zearalenone results in increased expression of ABCB1B mRNA; Zearalenone results in increased expression of ABCB1B protein

PMID:22521637 PMID:23707492

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 1

increases expression
increases transport
multiple interactions
affects expression
decreases expression

Zearalenone results in increased expression of ABCC1 protein
ABCC1 protein results in increased transport of Zearalenone
verlukast inhibits the reaction [ABCC1 protein results in increased transport of Zearalenone]; Zearalenone inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]
Zearalenone affects the expression of ABCC1 mRNA; Zearalenone affects the expression of ABCC1 protein
Zearalenone results in decreased expression of ABCC1 mRNA; Zearalenone results in decreased expression of ABCC1 protein

PMID:19580841 PMID:19647055 PMID:22521637 PMID:23707492

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

increases expression
multiple interactions
increases transport

Zearalenone results in increased expression of ABCC2 mRNA
verlukast inhibits the reaction [ABCC2 protein results in increased transport of Zearalenone]; Zearalenone inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]

PMID:19580841 PMID:19647055

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

decreases expression
multiple interactions
affects expression

Zearalenone results in decreased expression of ABCC3 mRNA
Zearalenone inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]
Zearalenone affects the expression of ABCC3 mRNA; Zearalenone affects the expression of ABCC3 protein

PMID:19371625 PMID:19647055 PMID:22521637

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

multiple interactions
decreases expression
increases expression

fulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCC4 mRNA]
Zearalenone results in decreased expression of ABCC4 protein
Zearalenone results in increased expression of ABCC4 mRNA; Zearalenone results in increased expression of ABCC4 protein

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 5

multiple interactions
affects expression
increases expression
decreases expression

fulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCC5 mRNA]
Zearalenone affects the expression of ABCC5 protein
Zearalenone results in decreased expression of ABCC5 mRNA

PMID:23707492 PMID:29627501

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

G

ATP binding cassette subfamily G member 2

increases expression
decreases expression
increases transport

Zearalenone results in increased expression of ABCG2 mRNA
Zearalenone results in increased expression of ABCG2 mRNA; Zearalenone results in increased expression of ABCG2 protein
Zearalenone results in decreased expression of ABCG2 mRNA; Zearalenone results in decreased expression of ABCG2 protein
ABCG2 protein results in increased transport of Zearalenone

PMID:19580841 PMID:22521637 PMID:23707492 PMID:30576553

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABRA C-terminal like

decreases expression

Zearalenone results in decreased expression of ABRACL protein

NCBI chr 1:12,654,951...12,665,143
Ensembl chr 1:12,654,838...12,665,207

G

acetyl-CoA carboxylase alpha

increases expression

Zearalenone results in increased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acetyl-CoA acetyltransferase 2

decreases expression

Zearalenone results in decreased expression of ACAT2 protein

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

atypical chemokine receptor 2

decreases expression

Zearalenone results in decreased expression of ACKR2 mRNA

NCBI chr 8:121,559,563...121,573,633
Ensembl chr 8:121,561,211...121,573,582

G

aconitase 1

decreases expression

Zearalenone results in decreased expression of ACO1 protein

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

acyl-CoA synthetase family member 2

increases expression

Zearalenone results in increased expression of ACSF2 protein

NCBI chr10:79,504,510...79,546,714
Ensembl chr10:79,504,511...79,546,673

G

actin related protein 3

multiple interactions

[Zearalenone co-treated with CGA protein] results in increased expression of ACTR3 protein

NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124

G

ADAM metallopeptidase with thrombospondin type 1 motif, 9

increases expression
decreases expression

Zearalenone results in increased expression of ADAMTS9 mRNA
Zearalenone results in decreased expression of ADAMTS9 mRNA

PMID:17557909 PMID:19371625

NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

decreases expression

Zearalenone results in decreased expression of ADH7 protein

NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182

G

ALF transcription elongation factor 3

increases expression

Zearalenone results in increased expression of AFF3 mRNA

NCBI chr 9:40,399,099...40,856,716
Ensembl chr 9:40,404,375...40,857,247

G

ArfGAP with FG repeats 2

increases expression

Zearalenone results in increased expression of AGFG2 protein

NCBI chr12:19,012,228...19,048,433
Ensembl chr12:19,012,258...19,048,421

G

angiotensinogen

increases expression

Zearalenone results in increased expression of AGT mRNA

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aryl hydrocarbon receptor

increases expression

Zearalenone results in increased expression of AHR mRNA

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

activator of Hsp90 ATPase activity 1

multiple interactions

[Zearalenone co-treated with CGA protein] results in increased expression of AHSA1 protein

NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345

G

activation-induced cytidine deaminase

increases expression

Zearalenone results in increased expression of AICDA mRNA

NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972

G

apoptosis inducing factor, mitochondria associated 1

increases expression

Zearalenone results in increased expression of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

aldo-keto reductase family 1 member B1

decreases expression

Zearalenone results in decreased expression of AKR1B1 protein

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

AKT serine/threonine kinase 1

decreases expression
increases expression
decreases phosphorylation
multiple interactions

Zearalenone results in decreased expression of AKT1 protein
Zearalenone results in increased expression of AKT1 mRNA
Zearalenone results in decreased phosphorylation of AKT1 protein
[Zearalenone co-treated with deoxynivalenol] results in decreased phosphorylation of AKT1 protein

PMID:31419471 PMID:32119988 PMID:32858132 PMID:35090964

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 3

decreases expression

Zearalenone results in decreased expression of AKT3 mRNA

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

aminolevulinate dehydratase

multiple interactions
decreases activity

lycopene inhibits the reaction [Zearalenone results in decreased activity of ALAD protein]

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

albumin

affects expression
multiple interactions
decreases expression

Zearalenone affects the expression of ALB mRNA
[deoxynivalenol co-treated with Zearalenone] affects the expression of ALB mRNA; [deoxynivalenol co-treated with Zearalenone] results in decreased expression of ALB protein; [deoxynivalenol co-treated with Zearalenone] results in increased expression of ALB mRNA
Zearalenone results in decreased expression of ALB protein

PMID:28865950 PMID:28935499 PMID:34537261

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldolase, fructose-bisphosphate B

multiple interactions
increases expression

[deoxynivalenol co-treated with Zearalenone] affects the expression of ALDOB mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of ALDOB mRNA
Zearalenone results in increased expression of ALDOB mRNA

PMID:28865950 PMID:28935499

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

aldolase, fructose-bisphosphate C

decreases expression

Zearalenone results in decreased expression of ALDOC protein

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

alkaline phosphatase, germ cell

increases expression

Zearalenone results in increased expression of ALPG mRNA

NCBI chr 9:87,748,721...87,761,500
Ensembl chr 9:87,753,648...87,757,836

G

alkaline phosphatase, biomineralization associated

multiple interactions

[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein; fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

anaphase promoting complex subunit 1

increases expression

Zearalenone results in increased expression of ANAPC1 mRNA

NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:115,850,185...115,930,273

G

anoctamin 1

increases expression

Zearalenone results in increased expression of ANO1 mRNA

NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069

G

acidic nuclear phosphoprotein 32 family member A

decreases expression

Zearalenone results in decreased expression of ANP32A protein

NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443

G

acidic nuclear phosphoprotein 32 family member B

decreases expression

Zearalenone results in decreased expression of ANP32B protein

NCBI chr 5:60,743,077...60,765,726
Ensembl chr 5:60,743,443...60,765,717

G

acidic nuclear phosphoprotein 32 family member E

decreases expression

Zearalenone results in decreased expression of ANP32E protein

NCBI chr 2:183,472,600...183,489,057
Ensembl chr 2:183,472,609...183,489,054

G

annexin A3

decreases expression

Zearalenone results in decreased expression of ANXA3 protein

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

annexin A5

affects binding

Zearalenone binds to ANXA5 protein

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

annexin A7

decreases expression

Zearalenone results in decreased expression of ANXA7 protein

NCBI chr15:3,821,798...3,849,659
Ensembl chr15:3,821,845...3,849,385

G

apoptotic peptidase activating factor 1

increases expression

Zearalenone results in increased expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

apelin

decreases expression

Zearalenone results in decreased expression of APLN mRNA

NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391

G

apolipoprotein B mRNA editing enzyme catalytic subunit 1

increases expression

Zearalenone results in increased expression of APOBEC1 mRNA

NCBI chr 4:155,800,030...155,828,515
Ensembl chr 4:155,800,887...155,827,390

G

apolipoprotein E

decreases expression

Zearalenone results in decreased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

adenine phosphoribosyl transferase

decreases expression

Zearalenone results in decreased expression of APRT protein

NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431

G

aquaporin 5

increases expression

Zearalenone results in increased expression of AQP5 mRNA

NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209

G

androgen receptor

multiple interactions
decreases expression
decreases activity

[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of AR protein; Zearalenone inhibits the reaction [Metribolone results in increased activity of AR protein]; Zearalenone inhibits the reaction [Testosterone binds to and results in increased activity of AR protein]
Zearalenone results in decreased expression of AR mRNA
Zearalenone metabolite results in decreased activity of AR protein; Zearalenone results in decreased activity of AR protein

PMID:18324785 PMID:21803136 PMID:24412631 PMID:25455890 PMID:27481073

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

Rho GTPase activating protein 26

increases expression

Zearalenone results in increased expression of ARHGAP26 mRNA

NCBI chr18:30,835,806...31,237,945
Ensembl chr18:30,838,671...31,235,194

G

aryl hydrocarbon receptor nuclear translocator

increases expression

Zearalenone results in increased expression of ARNT mRNA

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

arsenite methyltransferase

decreases expression

Zearalenone results in decreased expression of AS3MT protein

NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872

G

N-acylsphingosine amidohydrolase 1

decreases expression

Zearalenone results in decreased expression of ASAH1 mRNA

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

asparaginase and isoaspartyl peptidase 1

increases expression

Zearalenone results in increased expression of ASRGL1 mRNA

NCBI chr 1:206,006,103...206,027,115
Ensembl chr 1:206,006,109...206,027,108

G

autophagy related 5

increases expression

Zearalenone results in increased expression of ATG5 mRNA; Zearalenone results in increased expression of ATG5 protein

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

decreases expression

Zearalenone results in decreased expression of ATIC protein

NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889

G

ATM serine/threonine kinase

increases expression
decreases expression

Zearalenone results in increased expression of ATM mRNA
Zearalenone results in decreased expression of ATM mRNA; Zearalenone results in decreased expression of ATM protein

PMID:27862621 PMID:29758222

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions

[Zearalenone co-treated with CGA protein] results in decreased expression of ATP1A1 protein

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATP synthase peripheral stalk-membrane subunit b

increases expression

Zearalenone results in increased expression of ATP5PB protein

NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418

G

ATP synthase mitochondrial F1 complex assembly factor 1

decreases expression

Zearalenone results in decreased expression of ATPAF1 mRNA

NCBI chr 5:129,265,789...129,292,463
Ensembl chr 5:129,266,404...129,293,556

G

BCL2 associated X, apoptosis regulator

affects localization
increases expression
multiple interactions

Zearalenone affects the localization of BAX protein
Zearalenone results in increased expression of BAX mRNA; Zearalenone results in increased expression of BAX protein
Zearalenone results in increased expression of BAX; Zearalenone results in increased expression of BAX mRNA; Zearalenone results in increased expression of BAX protein
Aflatoxin B1 inhibits the reaction [Zearalenone results in increased expression of BAX mRNA]; crocin inhibits the reaction [Zearalenone results in increased expression of BAX protein]; deoxynivalenol promotes the reaction [Zearalenone results in increased expression of BAX mRNA]
[Zearalenone co-treated with deoxynivalenol] results in increased expression of BAX mRNA; [Zearalenone co-treated with deoxynivalenol] results in increased expression of BAX protein

PMID:19541794 PMID:21767629 PMID:24530352 PMID:25445755 PMID:26231423 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
increases expression
multiple interactions

Zearalenone results in decreased expression of BCL2 mRNA; Zearalenone results in decreased expression of BCL2 protein
Zearalenone results in increased expression of BCL2 mRNA
crocin inhibits the reaction [Zearalenone results in decreased expression of BCL2 protein]

PMID:21767629 PMID:24412631 PMID:26231423 PMID:28089945 PMID:28965971 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

decreases expression

Zearalenone results in decreased expression of BDNF mRNA

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

increases expression
multiple interactions

Zearalenone results in increased expression of BECN1; Zearalenone results in increased expression of BECN1 protein
acadesine promotes the reaction [Zearalenone results in increased expression of BECN1 protein]

PMID:24530352 PMID:31982503 PMID:32858132

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

BEN domain containing 3

increases expression

Zearalenone results in increased expression of BEND3 mRNA

NCBI chr20:46,980,246...47,017,059
Ensembl chr20:46,979,831...47,014,671

G

bifunctional apoptosis regulator

increases expression

Zearalenone results in increased expression of BFAR protein

NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038

G

BICD cargo adaptor 1

increases expression

Zearalenone results in increased expression of BICD1 mRNA

NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434

G

BH3 interacting domain death agonist

increases activity
multiple interactions

Zearalenone results in increased activity of BID protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Zearalenone results in increased activity of BID protein]

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 5

increases expression

Zearalenone results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

B-cell linker

decreases expression

Zearalenone results in decreased expression of BLNK mRNA

NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113

G

Bcl2 modifying factor

decreases expression

Zearalenone results in decreased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

bone morphogenetic protein 3

decreases expression

Zearalenone results in decreased expression of BMP3 mRNA

NCBI chr14:10,712,489...10,737,153
Ensembl chr14:10,712,489...10,737,153

G

BCL2 interacting protein 1

increases expression

Zearalenone results in increased expression of BNIP1 mRNA

NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157

G

bolA family member 2

decreases expression

Zearalenone results in decreased expression of BOLA2 protein

NCBI chr 1:181,291,967...181,292,833
Ensembl chr 1:181,291,398...181,292,676

G

B-Raf proto-oncogene, serine/threonine kinase

increases expression

Zearalenone results in increased expression of BRAF protein

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

BRCA1, DNA repair associated

increases expression

Zearalenone results in increased expression of BRCA1 mRNA

PMID:28552778 PMID:28965971

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

BUD31 homolog

increases expression

Zearalenone results in increased expression of BUD31 protein

NCBI chr12:9,462,838...9,470,387
Ensembl chr12:9,462,441...9,470,509

G

C1GALT1-specific chaperone 1

increases expression

Zearalenone results in increased expression of C1GALT1C1 protein

NCBI chr X:117,378,123...117,382,620
Ensembl chr X:117,375,525...117,382,787

G

complement C3

increases expression

Zearalenone results in increased expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

Cdk5 and Abl enzyme substrate 1

increases expression

Zearalenone results in increased expression of CABLES1 mRNA

PMID:19371625 PMID:36828454

NCBI chr18:3,076,556...3,181,181
Ensembl chr18:3,075,524...3,181,181

G

cell adhesion molecule 1

increases expression

Zearalenone results in increased expression of CADM1 mRNA

NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833

G

calreticulin

multiple interactions

[Zearalenone co-treated with CGA protein] results in decreased expression of CALR protein

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calcium/calmodulin-dependent protein kinase kinase 2

increases phosphorylation
multiple interactions

Zearalenone results in increased phosphorylation of CAMKK2 protein
2-aminoethyl diphenylborinate inhibits the reaction [Zearalenone results in increased phosphorylation of CAMKK2 protein]; STO 609 inhibits the reaction [Zearalenone results in increased phosphorylation of CAMKK2 protein]

NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279

G

calpain 9

increases expression

Zearalenone results in increased expression of CAPN9 mRNA

NCBI chr19:52,549,448...52,586,413
Ensembl chr19:52,549,448...52,586,413

G

carbonic anhydrase 12

increases expression

Zearalenone results in increased expression of CA12 mRNA

PMID:33419253 PMID:36828454

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

carbonic anhydrase 2

increases expression

Zearalenone results in increased expression of CA2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

calcium regulated heat stable protein 1

decreases expression

Zearalenone results in decreased expression of CARHSP1 protein

NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019

G

cysteinyl-tRNA synthetase 1

increases expression

Zearalenone results in increased expression of CARS1 mRNA

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

caspase 1

increases expression
multiple interactions

Zearalenone results in increased expression of CASP1 mRNA; Zearalenone results in increased expression of CASP1 protein
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of CASP1 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of CASP1 protein
Zearalenone results in increased expression of CASP1 protein modified form
3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; pyrrolidine dithiocarbamic acid inhibits the reaction [Zearalenone results in increased expression of CASP1 protein modified form]; Sirolimus inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]

PMID:30270565 PMID:31586597

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases activity
multiple interactions
increases expression
increases cleavage
decreases expression

Zearalenone results in increased activity of CASP3 protein
HERPUD1 protein promotes the reaction [Zearalenone results in increased expression of CASP3 protein modified form]; RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]; scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased cleavage of CASP3 protein]; Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]
Zearalenone results in increased expression of CASP3 mRNA; Zearalenone results in increased expression of CASP3 protein modified form
[Zearalenone co-treated with Aflatoxin B1] promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]; [Zearalenone co-treated with deoxynivalenol] results in increased expression of CASP3 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Zearalenone results in increased cleavage of CASP3 protein]; Zearalenone results in decreased expression of and results in increased cleavage of CASP3 protein
Zearalenone results in decreased expression of CASP3 protein

PMID:19541794 PMID:19705349 PMID:24530352 PMID:25445755 PMID:28089945 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases expression
multiple interactions
increases cleavage

Zearalenone results in increased expression of CASP8 mRNA
[Aflatoxin B1 co-treated with deoxynivalenol] promotes the reaction [Zearalenone results in increased expression of CASP8 mRNA]; [Zearalenone co-treated with Aflatoxin B1] promotes the reaction [deoxynivalenol results in increased expression of CASP8 mRNA]; [Zearalenone co-treated with deoxynivalenol] promotes the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA]; Zearalenone promotes the reaction [[Aflatoxin B1 co-treated with deoxynivalenol] results in increased expression of CASP8 mRNA]
Zearalenone results in increased cleavage of CASP8 protein

PMID:30600648 PMID:30668976

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
multiple interactions
increases expression
increases cleavage

Zearalenone results in increased activity of CASP9 protein
Zearalenone promotes the reaction [[Aflatoxin B1 co-treated with deoxynivalenol] results in increased expression of CASP9 mRNA]
Zearalenone results in increased expression of CASP9 mRNA
Zearalenone results in increased cleavage of CASP9 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Zearalenone results in increased cleavage of CASP9 protein]
Zearalenone results in increased expression of CASP9 protein modified form

PMID:24530352 PMID:30600648 PMID:30668976 PMID:34537261 PMID:36288102

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases expression
decreases expression
multiple interactions
decreases activity
increases activity

Zearalenone results in increased expression of CAT mRNA
Zearalenone results in decreased expression of CAT protein
Zearalenone results in decreased expression of CAT mRNA; Zearalenone results in decreased expression of CAT protein
Gallic Acid inhibits the reaction [Zearalenone results in decreased activity of CAT protein]
Zearalenone results in increased activity of CAT protein
[Nicotinamide Mononucleotide co-treated with Zearalenone] results in decreased expression of CAT protein; crocin inhibits the reaction [Zearalenone results in increased activity of CAT protein]

PMID:26231423 PMID:28089945 PMID:28477956 PMID:32858132 PMID:34723416 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

CBFA2/RUNX1 partner transcriptional co-repressor 3

increases expression

Zearalenone results in increased expression of CBFA2T3 mRNA

NCBI chr19:50,679,897...50,750,028
Ensembl chr19:50,680,729...50,749,610

G

cerebellin 1 precursor

increases expression

Zearalenone results in increased expression of CBLN1 mRNA

NCBI chr19:19,608,763...19,612,572
Ensembl chr19:19,608,716...19,612,572

G

carbonyl reductase 1

decreases expression

Zearalenone results in decreased expression of CBR1 protein

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

C-C motif chemokine ligand 21

increases expression

Zearalenone results in increased expression of CCL21 mRNA

NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686

G

C-C motif chemokine ligand 22

increases expression

Zearalenone results in increased expression of CCL22 mRNA

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

cellular communication network factor 5

increases expression

Zearalenone results in increased expression of CCN5 mRNA

NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636

G

cyclin A1

decreases expression

Zearalenone results in decreased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin B1

decreases expression

Zearalenone results in decreased expression of CCNB1 mRNA; Zearalenone results in decreased expression of CCNB1 protein

PMID:27862621 PMID:35504548

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

decreases expression
multiple interactions
increases expression

Zearalenone results in decreased expression of CCND1 mRNA
[Tamoxifen co-treated with Zearalenone] results in increased expression of CCND1 protein
Zearalenone results in increased expression of CCND1 mRNA; Zearalenone results in increased expression of CCND1 protein
Zearalenone results in decreased expression of CCND1 protein

PMID:24412631 PMID:27473017 PMID:30138655 PMID:36288102

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

decreases expression

Zearalenone results in decreased expression of CCND2 mRNA

PMID:17557909 PMID:28965971

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin E1

multiple interactions

[Zearalenone co-treated with Aflatoxin B1] results in increased expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

C-C motif chemokine receptor 1

increases expression

Zearalenone results in increased expression of CCR1 mRNA

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 4

increases expression

Zearalenone results in increased expression of CCR4 mRNA

NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056

G

chaperonin containing TCP1 subunit 2

decreases expression

Zearalenone results in decreased expression of CCT2 protein

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

G

chaperonin containing TCP1 subunit 5

increases expression
decreases expression

Zearalenone results in increased expression of CCT5 protein
Zearalenone results in decreased expression of CCT5 protein

PMID:25058043 PMID:36252740

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

CD274 molecule

increases expression

Zearalenone results in increased expression of CD274 mRNA

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

CD36 molecule

multiple interactions
decreases expression
increases expression

[Zearalenone co-treated with CGA protein] results in decreased expression of CD36 protein; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of CD36 mRNA]
Zearalenone results in decreased expression of CD36 mRNA; Zearalenone results in decreased expression of CD36 protein

PMID:25058043 PMID:32858132 PMID:38159578

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD38 molecule

increases expression
multiple interactions

Zearalenone results in increased expression of CD38 mRNA
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of CD38 mRNA]

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

CD86 molecule

multiple interactions

[Lipopolysaccharides co-treated with Zearalenone] results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cell division cycle 25C

decreases expression

Zearalenone results in decreased expression of CDC25C protein

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 6

decreases expression

Zearalenone results in decreased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cell division cycle associated 7

increases expression

Zearalenone results in increased expression of CDCA7 mRNA

NCBI chr 3:57,322,718...57,333,353
Ensembl chr 3:57,322,708...57,333,353

G

cadherin 1

decreases expression

Zearalenone results in decreased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase 1

decreases expression

Zearalenone results in decreased expression of CDK1 protein

PMID:34716709 PMID:35504548

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 4

increases expression

Zearalenone results in increased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

decreases expression

Zearalenone results in decreased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1C

decreases expression

Zearalenone results in decreased expression of CDKN1C mRNA

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

cyclin-dependent kinase inhibitor 2A

decreases expression

Zearalenone results in decreased expression of CDKN2A mRNA

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

CCAAT/enhancer binding protein alpha

affects expression
multiple interactions

Zearalenone affects the expression of CEBPA mRNA
[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein beta

increases expression

Zearalenone results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

CCAAT/enhancer binding protein delta

increases expression

Zearalenone results in increased expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

cilia and flagella associated protein 99

decreases expression

Zearalenone results in decreased expression of CFAP99 protein

NCBI chr14:76,423,923...76,468,170
Ensembl chr14:76,410,555...76,468,125

G

complement factor I

increases expression

Zearalenone results in increased expression of CFI mRNA

NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561

G

glycoprotein hormones, alpha polypeptide

multiple interactions
increases expression

fulvestrant inhibits the reaction [Zearalenone results in increased expression of CGA protein]
[Zearalenone co-treated with CGA protein] results in decreased expression of ATP1A1 protein; [Zearalenone co-treated with CGA protein] results in decreased expression of CALR protein; [Zearalenone co-treated with CGA protein] results in decreased expression of CD36 protein; [Zearalenone co-treated with CGA protein] results in decreased expression of HSD17B11 protein; [Zearalenone co-treated with CGA protein] results in decreased expression of MGLL protein; [Zearalenone co-treated with CGA protein] results in decreased expression of P4HB protein; [Zearalenone co-treated with CGA protein] results in decreased expression of SMPDL3B protein; [Zearalenone co-treated with CGA protein] results in decreased expression of SYAP1 protein; [Zearalenone co-treated with CGA protein] results in increased expression of ACTR3 protein; [Zearalenone co-treated with CGA protein] results in increased expression of AHSA1 protein; [Zearalenone co-treated with CGA protein] results in increased expression of DNM1L protein; [Zearalenone co-treated with CGA protein] results in increased expression of PDCD6IP protein; [Zearalenone co-treated with CGA protein] results in increased expression of PHGDH protein; [Zearalenone co-treated with CGA protein] results in increased expression of TLN1 protein; [Zearalenone co-treated with CGA protein] results in increased expression of YKT6 protein

PMID:19580841 PMID:25058043

NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

Zearalenone results in increased expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

ChaC glutathione specific gamma-glutamylcyclotransferase 2

increases expression

Zearalenone results in increased expression of CHAC2 mRNA

NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301

G

coiled-coil-helix-coiled-coil-helix domain containing 3

increases expression

Zearalenone results in increased expression of CHCHD3 protein

NCBI chr 4:61,360,352...61,616,850
Ensembl chr 4:61,360,353...61,616,847

G

checkpoint kinase 1

increases expression
decreases phosphorylation

Zearalenone results in increased expression of CHEK1 protein
Zearalenone results in decreased phosphorylation of CHK1 protein

PMID:34716709 PMID:35504548

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

decreases expression

Zearalenone results in decreased expression of CHEK2 protein

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

cysteine and histidine rich domain containing 1

decreases expression

Zearalenone results in decreased expression of CHORDC1 protein

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

cytokine inducible SH2-containing protein

increases expression

Zearalenone results in increased expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

creatine kinase B

decreases expression

Zearalenone results in decreased expression of CKB protein

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

claudin 1

decreases expression
multiple interactions

Zearalenone results in decreased expression of CLDN1 protein
[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CLDN1 mRNA; [deoxynivalenol co-treated with Zearalenone] results in decreased expression of CLDN1 protein

PMID:28865950 PMID:28935499

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

claudin 8

decreases expression

Zearalenone results in decreased expression of CLDN8 mRNA

NCBI chr11:27,875,857...27,878,106
Ensembl chr11:27,875,692...27,878,513

G

cornifelin

decreases expression

Zearalenone results in decreased expression of CNFN mRNA

NCBI chr 1:80,949,699...80,953,747
Ensembl chr 1:80,951,600...80,953,747

G

calponin 3

decreases expression

Zearalenone results in decreased expression of CNN3 protein

NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104

G

cytochrome C oxidase assembly factor 5

increases expression

Zearalenone results in increased expression of COA5 protein

NCBI chr 9:39,651,459...39,664,870

G

COP9 signalosome subunit 8

decreases expression

Zearalenone results in decreased expression of COPS8 protein

NCBI chr 9:91,207,427...91,217,258
Ensembl chr 9:91,207,395...91,217,258

G

coronin 1C

increases expression

Zearalenone results in increased expression of CORO1C mRNA

NCBI chr12:42,713,024...42,785,179
Ensembl chr12:42,712,991...42,785,179

G

carnitine palmitoyltransferase 1A

increases expression
multiple interactions

Zearalenone results in increased expression of CPT1A mRNA
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of CPT1A mRNA]

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

carnitine palmitoyltransferase 2

increases expression

Zearalenone results in increased expression of CPT2 protein

PMID:25058043 PMID:36252740

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

G

cellular retinoic acid binding protein 2

decreases expression

Zearalenone results in decreased expression of CRABP2 protein

NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379

G

crystallin beta-gamma domain containing 2

decreases expression

Zearalenone results in decreased expression of CRYBG2 mRNA

NCBI chr 5:146,286,406...146,318,417
Ensembl chr 5:146,286,925...146,323,666

G

chromosome segregation 1 like

decreases expression

Zearalenone results in decreased expression of CSE1L protein

NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865

G

colony stimulating factor 2

increases expression

Zearalenone results in increased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

cystatin E/M

decreases expression

Zearalenone results in decreased expression of CST6 mRNA

NCBI chr 1:202,655,322...202,657,030
Ensembl chr 1:202,655,322...202,657,030

G

cytotoxic T-lymphocyte-associated protein 4

increases expression

Zearalenone results in increased expression of CTLA4 mRNA

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

catenin beta 1

decreases expression

Zearalenone results in decreased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

increases expression

Zearalenone results in increased expression of CTSD mRNA

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cutA divalent cation tolerance homolog

decreases expression

Zearalenone results in decreased expression of CUTA mRNA

NCBI chr20:5,022,956...5,024,580
Ensembl chr20:5,022,956...5,024,552

G

cut-like homeobox 1

decreases expression

Zearalenone results in decreased expression of CUX1 mRNA

NCBI chr12:20,107,062...20,425,868
Ensembl chr12:20,107,311...20,425,866
Ensembl chr 4:20,107,311...20,425,866

G

CUB and zona pellucida-like domains 1

increases expression

Zearalenone results in increased expression of CUZD1 mRNA

NCBI chr 1:186,089,422...186,130,536
Ensembl chr 1:186,089,423...186,102,546

G

C-X-C motif chemokine ligand 12

increases expression

Zearalenone results in increased expression of CXCL12 mRNA

PMID:27757495 PMID:28396216

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 9

increases expression

Zearalenone results in increased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

C-X-C motif chemokine receptor 5

increases expression

Zearalenone results in increased expression of CXCR5 mRNA

NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893

G

cytochrome c, somatic

affects localization
increases expression

Zearalenone affects the localization of CYCS protein
Zearalenone results in increased expression of CYCS protein

PMID:19541794 PMID:25058043

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions
decreases activity

Zearalenone results in decreased expression of CYP11A1 mRNA; Zearalenone results in decreased expression of CYP11A1 protein
[Colforsin co-treated with Zearalenone] results in increased expression of CYP11A1 mRNA
Zearalenone results in decreased activity of CYP11A1 protein

PMID:24512812 PMID:26783879 PMID:29669061 PMID:31419471

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

Zearalenone results in decreased expression of CYP17A1 mRNA

PMID:24512812 PMID:32858132

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity
decreases expression

Zearalenone results in decreased activity of CYP19A1 protein
Zearalenone results in decreased expression of CYP19A1 mRNA; Zearalenone results in decreased expression of CYP19A1 protein

PMID:16023337 PMID:29758222 PMID:36374910

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
decreases expression

Tamoxifen inhibits the reaction [Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Tamoxifen inhibits the reaction [Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Zearalenone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Zearalenone results in decreased activity of CYP1A1 protein
Zearalenone results in decreased expression of CYP1A1 mRNA

PMID:15157572 PMID:34181028

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases hydroxylation
multiple interactions
decreases activity
decreases abundance

CYP1A2 protein results in increased hydroxylation of Zearalenone
[CYP1A2 protein results in increased hydroxylation of Zearalenone] which results in increased chemical synthesis of Catechols
Zearalenone results in decreased activity of CYP1A2 protein
CYP1A2 protein results in decreased abundance of Zearalenone

PMID:19931366 PMID:38341109

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases activity
multiple interactions

Zearalenone results in increased activity of CYP1B1 protein
Zearalenone promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1B1 protein]

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily c, polypeptide 7

increases expression

Zearalenone results in increased expression of CYP2C7 mRNA

NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

Zearalenone results in increased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
multiple interactions
decreases abundance
decreases activity

Zearalenone results in increased expression of CYP3A2 mRNA
Zearalenone results in increased expression of CYP3A4 mRNA; Zearalenone results in increased expression of CYP3A4 protein
[deoxynivalenol co-treated with Zearalenone] affects the expression of CYP3A4 mRNA; [deoxynivalenol co-treated with Zearalenone] results in decreased expression of CYP3A4 protein; [deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP3A4 mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP3A4 protein; Zearalenone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4]
CYP3A4 protein results in decreased abundance of Zearalenone
Zearalenone results in decreased activity of CYP3A4 protein

PMID:15569515 PMID:20607812 PMID:28865950 PMID:28935499 PMID:36893891 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

Zearalenone results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 4, subfamily f, polypeptide 18

multiple interactions
decreases expression

[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CYP4F3 mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP4F3 mRNA
Zearalenone results in decreased expression of CYP4F3 mRNA

PMID:28865950 PMID:28935499

NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940

G

cytochrome P450, family 51

increases expression

Zearalenone results in increased expression of CYP51 protein

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

cysteine rich tail 1

decreases expression

Zearalenone results in decreased expression of CYSRT1 mRNA

NCBI chr 3:8,054,195...8,057,846
Ensembl chr 3:8,053,482...8,059,721

G

aspartyl-tRNA synthetase 1

decreases expression

Zearalenone results in decreased expression of DARS1 protein

NCBI chr13:39,857,936...39,913,055
Ensembl chr13:39,857,936...39,913,116

G

deleted in azoospermia-like

decreases expression

Zearalenone results in decreased expression of DAZL mRNA; Zearalenone results in decreased expression of DAZL protein

PMID:28552778 PMID:31419471

NCBI chr 9:10,695,593...10,712,330
Ensembl chr 9:10,695,592...10,712,323

G

dopa decarboxylase

decreases expression

Zearalenone results in decreased expression of DDC mRNA

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

Zearalenone results in increased expression of DDIT3 protein
2-aminoethyl diphenylborinate inhibits the reaction [Zearalenone results in increased expression of DDIT3 protein]; 4-phenylbutylamine promotes the reaction [Zearalenone results in increased expression of DDIT3 protein]

PMID:30394307 PMID:31982503

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4-like

decreases expression

Zearalenone results in decreased expression of DDIT4L mRNA

NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375

G

DEAD-box helicase 25

decreases expression

Zearalenone results in decreased expression of DDX25 mRNA

NCBI chr 8:33,894,224...33,910,377
Ensembl chr 8:33,894,232...33,921,764

G

DEAD-box helicase 4

decreases expression

Zearalenone results in decreased expression of DDX4 protein; Zearalenone results in decreased expression of VASA protein

PMID:28089945 PMID:31419471

NCBI chr 2:44,227,946...44,282,867
Ensembl chr 2:44,227,946...44,282,723

G

DEP domain containing MTOR-interacting protein

increases expression

Zearalenone results in increased expression of DEPTOR mRNA

PMID:33419253 PMID:36828454

NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773

G

diacylglycerol O-acyltransferase 1

multiple interactions
increases expression

Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of DGAT1 mRNA]

NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299

G

diacylglycerol O-acyltransferase 2

multiple interactions
increases expression

Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of DGAT2 mRNA]

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

G

dehydrogenase/reductase 2

increases expression

Zearalenone results in increased expression of DHRS2 mRNA

NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644

G

dehydrogenase/reductase 3

increases expression

Zearalenone results in increased expression of DHRS3 mRNA

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

DIO3 opposite strand upstream RNA

decreases expression

Zearalenone results in decreased expression of DIO3OS mRNA

G

DIRAS family GTPase 3

increases expression

Zearalenone results in increased expression of DIRAS3 mRNA

NCBI chr 6:130,524,972...130,526,186
Ensembl chr 6:130,524,742...130,530,825

G

dickkopf WNT signaling pathway inhibitor 2

decreases expression

Zearalenone results in decreased expression of DKK2 mRNA

NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225

G

dihydrolipoamide dehydrogenase

increases expression

Zearalenone results in increased expression of DLD protein

NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795

G

deleted in malignant brain tumors 1

increases expression

Zearalenone results in increased expression of DMBT1 mRNA

NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478

G

dynamin 1-like

multiple interactions

[Zearalenone co-treated with CGA protein] results in increased expression of DNM1L protein

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

DNA methyltransferase 1

increases expression

Zearalenone results in increased expression of DNMT1 mRNA

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

deoxyhypusine hydroxylase

decreases expression

Zearalenone results in decreased expression of DOHH protein

NCBI chr 7:8,321,466...8,326,305
Ensembl chr 7:8,321,466...8,326,289

G

docking protein 4

increases expression

Zearalenone results in increased expression of DOK4 mRNA

NCBI chr19:10,146,520...10,157,187
Ensembl chr19:10,146,474...10,158,203

G

dihydropyrimidinase-like 2

decreases expression

Zearalenone results in decreased expression of DPYSL2 protein

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

destrin, actin depolymerizing factor

decreases expression

Zearalenone results in decreased expression of DSTN protein

NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379

G

dual specificity phosphatase 2

increases expression

Zearalenone results in increased expression of DUSP2 mRNA

NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499

G

dishevelled segment polarity protein 1

increases expression

Zearalenone results in increased expression of DVL1 mRNA

NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664

G

dynein, cytoplasmic 1 light intermediate chain 2

decreases expression

Zearalenone results in decreased expression of DYNC1LI2 protein

NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670

G

endothelin-converting enzyme 2

decreases expression

Zearalenone results in decreased expression of ECE2 protein

NCBI chr11:80,259,130...80,278,446
Ensembl chr11:80,263,162...80,278,428

G

enoyl-CoA hydratase 1

decreases expression

Zearalenone results in decreased expression of ECH1 mRNA

NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795

G

enoyl-CoA hydratase, short chain 1

decreases expression

Zearalenone results in decreased expression of ECHS1 mRNA; Zearalenone results in decreased expression of ECHS1 protein

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

eukaryotic translation elongation factor 1 beta 2

decreases expression

Zearalenone results in decreased expression of EEF1B2 protein

NCBI chr 9:64,580,163...64,582,737
Ensembl chr 9:64,579,893...64,582,737

G

elongation factor like GTPase 1

decreases expression

Zearalenone results in decreased expression of EFL1 protein

NCBI chr 1:136,638,527...136,763,518
Ensembl chr 1:136,638,527...136,763,518

G

early growth response 1

increases expression

Zearalenone results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

euchromatic histone lysine methyltransferase 2

increases expression

Zearalenone results in increased expression of EHMT2 mRNA

NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547

G

eukaryotic translation initiation factor 1A, X-linked

decreases expression

Zearalenone results in decreased expression of EIF1AX protein

NCBI chr X:35,498,698...35,513,402
Ensembl chr X:35,498,517...35,513,335

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation

Zearalenone results in decreased phosphorylation of EIF4EBP1 protein

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

ELOVL fatty acid elongase 3

multiple interactions
increases expression

Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of ELOVL3 mRNA]

NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115

G

E1A binding protein p300

decreases expression

Zearalenone results in decreased expression of EP300 protein

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

endothelial PAS domain protein 1

increases expression

Zearalenone results in increased expression of EPAS1 mRNA

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

erythrocyte membrane protein band 4.1-like 2

increases expression

Zearalenone results in increased expression of EPB41L2 mRNA

NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721

G

Eph receptor B3

decreases expression

Zearalenone results in decreased expression of EPHB3 mRNA

NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370

G

EPH receptor B4

increases expression

Zearalenone results in increased expression of EPHB4 protein

NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314

G

epsin 3

decreases expression

Zearalenone results in decreased expression of EPN3 mRNA

NCBI chr10:79,438,978...79,449,516
Ensembl chr10:79,438,978...79,447,356

G

erb-b2 receptor tyrosine kinase 3

decreases expression

Zearalenone results in decreased expression of ERBB3 mRNA

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

ERCC excision repair 3, TFIIH core complex helicase subunit

increases expression

Zearalenone results in increased expression of ERCC3 mRNA

NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329

G

ETS transcription factor ERG

increases expression

Zearalenone results in increased expression of ERG mRNA

NCBI chr11:34,678,614...34,900,951
Ensembl chr11:34,678,618...34,845,871

G

glutamate-rich 3

increases expression

Zearalenone results in increased expression of ERICH3 mRNA

NCBI chr 2:243,615,777...243,717,973
Ensembl chr 2:243,615,872...243,715,317

G

endoplasmic reticulum protein 27

decreases expression

Zearalenone results in decreased expression of ERP27 mRNA

NCBI chr 4:169,804,656...169,821,660
Ensembl chr 4:169,804,658...169,821,660

G

establishment of sister chromatid cohesion N-acetyltransferase 1

increases expression

Zearalenone results in increased expression of ESCO1 mRNA

NCBI chr18:1,630,560...1,686,803
Ensembl chr18:1,631,954...1,686,942

G

espin

increases expression

Zearalenone results in increased expression of ESPN mRNA

NCBI chr 5:162,626,560...162,660,439
Ensembl chr 5:162,626,560...162,660,256

G

estrogen receptor 1

multiple interactions
increases activity
affects binding
affects expression
decreases expression
affects response to substance

[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein; Fulvestrant inhibits the reaction [[Zearalenone binds to ESR1 protein] which results in increased activity of ALPL protein]; Zearalenone analog promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone binds to and results in decreased activity of ESR1 protein; Zearalenone binds to and results in increased activity of ESR1 protein; Zearalenone promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; Zearalenone promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [NCOA2 protein binds to ESR1 protein]
Zearalenone results in increased activity of ESR1 protein
Zearalenone affects the expression of ESR1 mRNA; Zearalenone affects the expression of ESR1 protein
Zearalenone analog binds to ESR1 protein; Zearalenone binds to ESR1 protein
Zearalenone metabolite results in increased activity of ESR1 protein; Zearalenone results in increased activity of ESR1 protein
Zearalenone results in decreased expression of ESR1 mRNA; Zearalenone results in decreased expression of ESR1 protein
ESR1 protein affects the susceptibility to Zearalenone

PMID:9751507 PMID:11162928 PMID:11331656 PMID:11750080 PMID:12598185 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
affects binding
decreases expression
increases expression

Zearalenone analog promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone binds to and results in decreased activity of ESR2 protein; Zearalenone binds to and results in increased activity of ESR2 protein; Zearalenone promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]
Zearalenone binds to ESR2 protein
Zearalenone analog binds to ESR2 protein; Zearalenone binds to ESR2 protein
Zearalenone results in decreased expression of ESR2 mRNA
[bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene] results in increased expression of ESR2 mRNA; [Estradiol co-treated with Triiodothyronine] promotes the reaction [Zearalenone results in decreased expression of ESR2 mRNA]; [Zearalenone co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA; [Zearalenone results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in decreased expression of ESR2 mRNA
Zearalenone results in increased expression of ESR2 mRNA
Dextran Sulfate promotes the reaction [Zearalenone results in increased expression of ESR2 mRNA]

PMID:9751507 PMID:15084758 PMID:15169976 PMID:19913605 PMID:27338438 More...

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

electron transfer flavoprotein subunit beta

increases expression

Zearalenone results in increased expression of ETFB protein

NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068

G

electron transfer flavoprotein dehydrogenase

increases expression

Zearalenone results in increased expression of ETFDH protein

NCBI chr 2:164,740,547...164,762,754
Ensembl chr 2:164,729,749...164,762,745

G

ethanolamine kinase 2

increases expression

Zearalenone results in increased expression of ETNK2 mRNA

NCBI chr13:44,811,012...44,829,052
Ensembl chr13:44,811,015...44,829,037

G

fatty acid binding protein 1

increases expression

Zearalenone results in increased expression of FABP1 mRNA

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

family with sequence similarity 107, member A

decreases expression

Zearalenone results in decreased expression of FAM107A mRNA

NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396

G

Fas cell surface death receptor

increases expression

Zearalenone results in increased expression of FAS mRNA; Zearalenone results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

Zearalenone results in increased expression of FASLG mRNA; Zearalenone results in increased expression of FASLG protein

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

multiple interactions
increases expression

Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of FASN mRNA]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

ferredoxin 1

decreases expression

Zearalenone results in decreased expression of FDX1 mRNA; Zearalenone results in decreased expression of FDX1 protein

NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414

G

folliculogenesis specific bHLH transcription factor

decreases expression

Zearalenone results in decreased expression of FIGLA mRNA

NCBI chr 4:118,432,517...118,436,846
Ensembl chr 4:118,432,765...118,436,690

G

filamin A interacting protein 1-like

decreases expression

Zearalenone results in decreased expression of FILIP1L mRNA

NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415

G

FKBP prolyl isomerase 4

decreases expression

Zearalenone results in decreased expression of FKBP4 protein

NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833

G

FKBP prolyl isomerase 5

decreases expression

Zearalenone results in decreased expression of FKBP5 mRNA

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

G

fructosamine-3-kinase-related protein

decreases expression

Zearalenone results in decreased expression of FN3KRP protein

NCBI chr10:106,688,413...106,697,137
Ensembl chr10:106,688,439...106,697,134

G

fibronectin type III domain containing 5

decreases expression

Zearalenone results in decreased expression of FNDC5 mRNA

NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731

G

folate receptor alpha

decreases expression

Zearalenone results in decreased expression of FOLR1 mRNA

NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Zearalenone results in increased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box D1

increases expression

Zearalenone results in increased expression of FOXD1 mRNA

NCBI chr 2:29,702,558...29,704,978
Ensembl chr 2:29,702,558...29,704,978

G

forkhead box J1

decreases expression

Zearalenone results in decreased expression of FOXJ1 mRNA

NCBI chr10:101,566,299...101,570,370
Ensembl chr10:101,566,304...101,570,237

G

forkhead box O1

decreases expression

Zearalenone results in decreased expression of FOXO1 mRNA

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O3

decreases expression

Zearalenone results in decreased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

follicle stimulating hormone subunit beta

decreases expression
multiple interactions

Zearalenone results in decreased expression of FSHB protein
Gallic Acid inhibits the reaction [Zearalenone results in decreased expression of FSHB protein]

PMID:32858132 PMID:34723416

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

follicle stimulating hormone receptor

decreases expression

Zearalenone results in decreased expression of FSHR mRNA; Zearalenone results in decreased expression of FSHR protein

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

G0/G1switch 2

increases expression

Zearalenone results in increased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucose-6-phosphate dehydrogenase

decreases activity
multiple interactions

Zearalenone results in decreased activity of G6PD protein
Gallic Acid inhibits the reaction [Zearalenone results in decreased activity of G6PD protein]

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Zearalenone results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

polypeptide N-acetylgalactosaminyltransferase 4

increases expression

Zearalenone results in increased expression of GALNT4 mRNA

NCBI chr 7:33,925,229...33,927,770

G

galanin receptor 2

decreases expression

Zearalenone results in decreased expression of GALR2 mRNA

NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176

G

growth associated protein 43

decreases expression

Zearalenone results in decreased expression of GAP43 mRNA

NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

Zearalenone results in decreased expression of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glycyl-tRNA synthetase 1

decreases expression

Zearalenone results in decreased expression of GARS1 protein

NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609

G

growth differentiation factor 10

decreases expression

Zearalenone results in decreased expression of GDF10 mRNA

NCBI chr16:9,237,182...9,250,537
Ensembl chr16:9,237,261...9,249,343

G

glial cell derived neurotrophic factor

decreases expression

Zearalenone results in decreased expression of GDNF protein

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glycerophosphodiester phosphodiesterase domain containing 5

increases expression

Zearalenone results in increased expression of GDPD5 mRNA

NCBI chr 1:153,679,718...153,761,452
Ensembl chr 1:153,679,718...153,761,446

G

GDNF family receptor alpha 2

decreases expression

Zearalenone results in decreased expression of GFRA2 mRNA

NCBI chr15:45,941,841...46,033,715
Ensembl chr15:45,941,828...46,033,714

G

GINS complex subunit 3

decreases expression

Zearalenone results in decreased expression of GINS3 mRNA

NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687

G

gap junction protein, alpha 1

decreases expression

Zearalenone results in decreased expression of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, beta 1

decreases expression

Zearalenone results in decreased expression of GJB1 protein

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

gap junction protein, beta 2

increases expression

Zearalenone results in increased expression of GJB2 mRNA

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

golgi glycoprotein 1

increases expression

Zearalenone results in increased expression of GLG1 protein

NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178

G

glutaredoxin 2

increases expression

Zearalenone results in increased expression of GLRX2 mRNA

NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831

G

gonadotropin releasing hormone 1

decreases expression

Zearalenone results in decreased expression of GNRH1 mRNA

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

gonadotropin releasing hormone receptor

decreases expression

Zearalenone results in decreased expression of GNRHR protein

NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861

G

glutamic-oxaloacetic transaminase 2

increases expression

Zearalenone results in increased expression of GOT2 protein

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

G protein-coupled estrogen receptor 1

affects binding
decreases expression

Zearalenone binds to GPER1 protein
Zearalenone results in decreased expression of GPER1 mRNA

PMID:17088055 PMID:28965971

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

G

G protein-coupled receptor 142

increases expression

Zearalenone results in increased expression of GPR142 mRNA

NCBI chr10:99,840,069...99,843,410
Ensembl chr10:99,840,069...99,843,410

G

glutamic--pyruvic transaminase

decreases expression
multiple interactions
increases activity
increases expression

Zearalenone results in decreased expression of GPT protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased activity of GPT protein]]; corynoline inhibits the reaction [Zearalenone results in increased activity of GPT protein]; crocin inhibits the reaction [Zearalenone results in increased expression of GPT protein]; Plant Extracts inhibits the reaction [Zearalenone results in increased expression of GPT protein]; Zearalenone inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]

PMID:17385802 PMID:25058043 PMID:25445755 PMID:26231423 PMID:36161741

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

decreases expression

Zearalenone results in decreased expression of GPX1 mRNA; Zearalenone results in decreased expression of GPX1 protein

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

growth factor receptor bound protein 7

decreases expression

Zearalenone results in decreased expression of GRB7 mRNA

NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052

G

growth regulating estrogen receptor binding 1

increases expression

Zearalenone results in increased expression of GREB1 mRNA

PMID:19371625 PMID:22494775 PMID:28807876 PMID:33419253 PMID:36828454

NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633

G

gasdermin D

decreases expression

Zearalenone results in decreased expression of GSDMD mRNA

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

G1 to S phase transition 1

decreases expression

Zearalenone results in decreased expression of GSPT1 protein

NCBI chr10:4,362,528...4,397,215
Ensembl chr10:4,362,510...4,397,198

G

glutathione-disulfide reductase

multiple interactions
decreases activity

lycopene inhibits the reaction [Zearalenone results in decreased activity of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 2

decreases expression

Zearalenone results in decreased expression of GSTM2 protein

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

decreases expression

Zearalenone results in decreased expression of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

H19 imprinted maternally expressed transcript

decreases expression

Zearalenone results in decreased expression of H19 mRNA

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

G

H2A.X variant histone

increases expression
decreases expression

Zearalenone results in increased expression of H2AX protein modified form
Zearalenone results in decreased expression of H2AX protein

PMID:28089945 PMID:28552778 PMID:35504548 PMID:35650142

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

decreases expression

Zearalenone results in decreased expression of HADHB mRNA; Zearalenone results in decreased expression of HADHB protein

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

hyaluronan and proteoglycan link protein 3

decreases expression

Zearalenone results in decreased expression of HAPLN3 mRNA

NCBI chr 1:133,046,465...133,064,665
Ensembl chr 1:133,046,467...133,080,177

G

histone acetyltransferase 1

increases expression

Zearalenone results in increased expression of HAT1 mRNA

NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517

G

hemoglobin alpha, adult chain 1

decreases expression

Zearalenone results in decreased expression of HBA-A1 mRNA

NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392

G

hemoglobin subunit beta

decreases expression

Zearalenone results in decreased expression of HBB mRNA

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression
multiple interactions

Zearalenone results in increased expression of HERPUD1 protein
4-phenylbutylamine promotes the reaction [Zearalenone results in increased expression of HERPUD1 protein]; HERPUD1 protein inhibits the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]; HERPUD1 protein promotes the reaction [Zearalenone results in decreased phosphorylation of MAPK1 protein]; HERPUD1 protein promotes the reaction [Zearalenone results in decreased phosphorylation of MAPK3 protein]; HERPUD1 protein promotes the reaction [Zearalenone results in increased expression of CASP3 protein modified form]

NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424

G

hes family bHLH transcription factor 2

increases expression

Zearalenone results in increased expression of HES2 mRNA

NCBI chr 5:162,667,190...162,668,235
Ensembl chr 5:162,667,190...162,668,235

G

histone cluster 1 H2B family member D

decreases expression

Zearalenone results in decreased expression of H2BC5 mRNA

NCBI chr17:42,792,887...42,793,268

G

HIVEP zinc finger 1

increases expression

Zearalenone results in increased expression of HIVEP1 mRNA

NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,585,016...22,711,956

G

hexokinase 2

increases expression

Zearalenone results in increased expression of HK2 mRNA

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

Zearalenone results in decreased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

high mobility group nucleosomal binding domain 2

decreases expression

Zearalenone results in decreased expression of HMGN2 mRNA

NCBI chr 5:146,192,126...146,195,580
Ensembl chr 5:146,192,126...146,195,521
Ensembl chr16:146,192,126...146,195,521

G

heme oxygenase 1

increases expression
multiple interactions

Zearalenone results in increased expression of HMOX1 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline promotes the reaction [Zearalenone results in increased expression of HMOX1 protein]]; corynoline promotes the reaction [Zearalenone results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hepatocyte nuclear factor 4, alpha

multiple interactions

[deoxynivalenol co-treated with Zearalenone] affects the expression of HNF4A mRNA

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

homeobox A10

decreases expression

Zearalenone results in decreased expression of HOXA10 mRNA

NCBI chr 4:81,331,591...81,340,878
Ensembl chr 4:81,331,591...81,340,919

G

4-hydroxyphenylpyruvate dioxygenase-like

increases expression

Zearalenone results in increased expression of HPDL mRNA

NCBI chr 5:130,286,627...130,288,233
Ensembl chr 5:130,286,631...130,288,233

G

HRas proto-oncogene, GTPase

decreases expression

Zearalenone results in decreased expression of HRAS mRNA

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

hydroxysteroid 11-beta dehydrogenase 1

decreases expression

Zearalenone results in decreased expression of HSD11B1 mRNA; Zearalenone results in decreased expression of HSD11B1 protein

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

hydroxysteroid (17-beta) dehydrogenase 1

decreases expression

Zearalenone results in decreased expression of HSD17B1 protein

NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927

G

hydroxysteroid (17-beta) dehydrogenase 11

multiple interactions

[Zearalenone co-treated with CGA protein] results in decreased expression of HSD17B11 protein

NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161

G

hydroxysteroid (17-beta) dehydrogenase 14

decreases expression

Zearalenone results in decreased expression of HSD17B14 mRNA

NCBI chr 1:96,029,224...96,039,577
Ensembl chr 1:96,029,284...96,039,883

G

hydroxysteroid (17-beta) dehydrogenase 2

increases expression

Zearalenone results in increased expression of HSD17B2 mRNA

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

G

hydroxysteroid (17-beta) dehydrogenase 3

decreases expression
decreases activity

Zearalenone results in decreased expression of HSD17B3 mRNA
Zearalenone results in decreased activity of HSD17B3 protein
Zearalenone results in decreased expression of HSD17B3 mRNA; Zearalenone results in decreased expression of HSD17B3 protein

PMID:24512812 PMID:29669061

NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554

G

hydroxysteroid (17-beta) dehydrogenase 4

decreases expression

Zearalenone results in decreased expression of HSD17B4 protein

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression
decreases activity

Zearalenone results in decreased expression of HSD3B1 mRNA
Zearalenone results in decreased activity of HSD3B1 protein

PMID:24512812 PMID:29669061

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

affects expression

Zearalenone affects the expression of HSD3B2 mRNA

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

heat shock protein 90 alpha family class B member 1

decreases expression

Zearalenone results in decreased expression of HSP90AB1 protein

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1A

increases expression
decreases expression

Zearalenone results in increased expression of HSPA1A mRNA; Zearalenone results in increased expression of HSPA1A protein
Zearalenone results in decreased expression of HSPA1A protein

PMID:19051279 PMID:36252740

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

increases expression

Zearalenone results in increased expression of HSPA1B mRNA

PMID:25424538 PMID:27862621

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 4

decreases expression

Zearalenone results in decreased expression of HSPA4 protein

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

2-aminoethyl diphenylborinate inhibits the reaction [Zearalenone results in increased expression of HSPA5 protein]; 4-phenylbutylamine promotes the reaction [Zearalenone results in increased expression of HSPA5 protein]

PMID:30394307 PMID:31982503

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

increases expression

Zearalenone results in increased expression of HSPB1 protein

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family B (small) member 8

decreases expression

Zearalenone results in decreased expression of HSPB8 protein

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

heat shock protein family H (Hsp110) member 1

decreases expression

Zearalenone results in decreased expression of HSPH1 protein

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

inhibitor of DNA binding 1

decreases expression

Zearalenone results in decreased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 2

increases expression
multiple interactions

Zearalenone results in increased expression of ID2 mRNA
[Tamoxifen co-treated with Zearalenone] results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

increases expression

Zearalenone results in increased expression of IDH3A protein

NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084

G

indoleamine 2,3-dioxygenase 1

decreases expression

Zearalenone results in decreased expression of IDO1 mRNA

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

interferon induced transmembrane protein 3

decreases expression

Zearalenone results in decreased expression of IFITM3 mRNA

NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203

G

insulin-like growth factor 1

increases expression
decreases expression

Zearalenone results in increased expression of IGF1 mRNA
Zearalenone results in decreased expression of IGF1 mRNA

PMID:27757495 PMID:28965971

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 3

decreases expression

Zearalenone results in decreased expression of IGFBP3 mRNA

PMID:28965971 PMID:36828454

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

insulin-like growth factor binding protein 6

decreases expression

Zearalenone results in decreased expression of IGFBP6 mRNA

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

G

immunoglobulin superfamily, member 9

decreases expression

Zearalenone results in decreased expression of IGSF9 mRNA

NCBI chr13:84,948,643...84,965,616
Ensembl chr13:84,948,619...84,965,607

G

IKAROS family zinc finger 2

decreases expression

Zearalenone results in decreased expression of IKZF2 mRNA

NCBI chr 9:71,046,038...71,191,296
Ensembl chr 9:71,042,440...71,190,867

G

interleukin 10

multiple interactions
increases expression

lycopene inhibits the reaction [Zearalenone results in increased expression of IL10]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12A

increases expression

Zearalenone results in increased expression of IL12A mRNA

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 13

increases expression

Zearalenone results in increased expression of IL13 mRNA

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 18

increases secretion
multiple interactions
increases expression

Zearalenone results in increased secretion of IL18 protein
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of IL18 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased secretion of IL18 protein; Dextran Sulfate inhibits the reaction [Zearalenone results in increased secretion of IL18 protein]; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of IL18 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of IL18 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased secretion of IL18 protein]

PMID:30270565 PMID:38159578

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions
increases expression
increases secretion

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased expression of IL1B protein]]; [Dextran Sulfate co-treated with Zearalenone] results in increased secretion of IL1B protein; corynoline inhibits the reaction [Zearalenone results in increased expression of IL1B protein]; Lipopolysaccharides promotes the reaction [Zearalenone results in increased expression of IL1B mRNA]; Lycopene inhibits the reaction [Zearalenone results in increased expression of IL1B]; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of IL1B mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]
Zearalenone results in increased expression of IL1B; Zearalenone results in increased expression of IL1B mRNA; Zearalenone results in increased expression of IL1B protein
Zearalenone results in increased secretion of IL1B protein
Zearalenone results in increased expression of IL1B protein modified form
3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]; NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Zearalenone results in increased expression of IL1B protein modified form]; Sirolimus inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]
[Zearalenone co-treated with deoxynivalenol] results in increased expression of IL1B mRNA

PMID:16687389 PMID:25682699 PMID:30270565 PMID:31586597 PMID:35090964 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

decreases expression

Zearalenone results in decreased expression of IL1RN mRNA

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

multiple interactions
increases expression

lycopene inhibits the reaction [Zearalenone results in increased expression of IL2]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

increases expression

Zearalenone results in increased expression of IL4 mRNA

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 4 receptor

increases expression

Zearalenone results in increased expression of IL4R mRNA

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

G

interleukin 6

multiple interactions
increases expression

Lipopolysaccharides promotes the reaction [Zearalenone results in increased expression of IL6 mRNA]; lycopene inhibits the reaction [Zearalenone results in increased expression of IL6]
[Lipopolysaccharides co-treated with Zearalenone] results in increased secretion of IL6 protein; [Zearalenone co-treated with Aflatoxin B1] results in decreased expression of IL6 mRNA; [Zearalenone co-treated with deoxynivalenol] results in increased expression of IL6 mRNA

PMID:16687389 PMID:25682699 PMID:28965971 PMID:32328699 PMID:35090964

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inner membrane mitochondrial protein

increases expression

Zearalenone results in increased expression of IMMT protein

NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109

G

inosine monophosphate dehydrogenase 2

increases expression

Zearalenone results in increased expression of IMPDH2 mRNA

NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359

G

inhibin subunit beta A

decreases expression

Zearalenone results in decreased expression of INHBA mRNA

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

importin 13

increases expression

Zearalenone results in increased expression of IPO13 mRNA

NCBI chr 5:131,433,770...131,454,044
Ensembl chr 5:131,433,776...131,454,043

G

isthmin 1

increases expression

Zearalenone results in increased expression of ISM1 mRNA

NCBI chr 3:127,023,296...127,102,228
Ensembl chr 3:127,021,865...127,101,894

G

inositol-3-phosphate synthase 1

decreases expression

Zearalenone results in decreased expression of ISYNA1 protein

NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979

G

inositol-tetrakisphosphate 1-kinase

increases expression

Zearalenone results in increased expression of ITPK1 mRNA

NCBI chr 6:121,710,750...121,844,501
Ensembl chr 6:121,710,755...121,844,107

G

jagged canonical Notch ligand 1

increases expression

Zearalenone results in increased expression of JAG1 mRNA

PMID:30138655 PMID:32858132

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

scutellarin inhibits the reaction [Zearalenone results in increased expression of JUN protein]

PMID:27473017 PMID:36252740

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

lysine acetyltransferase 2B

increases expression

Zearalenone results in increased expression of KAT2B mRNA

NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064

G

kazrin, periplakin interacting protein

increases expression

Zearalenone results in increased expression of KAZN mRNA

NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074

G

kelch repeat and BTB domain containing 8

increases expression

Zearalenone results in increased expression of KBTBD8 mRNA

NCBI chr 4:127,675,967...127,688,785
Ensembl chr 4:127,676,141...127,687,697

G

potassium voltage-gated channel modifier subfamily F member 1

increases expression

Zearalenone results in increased expression of KCNF1 mRNA

PMID:19371625 PMID:36828454

NCBI chr 6:39,962,301...39,964,979
Ensembl chr 6:39,962,307...39,964,979

G

potassium inwardly-rectifying channel, subfamily J, member 2

increases expression

Zearalenone results in increased expression of KCNJ2 mRNA

NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445

G

potassium inwardly-rectifying channel, subfamily J, member 5

increases expression

Zearalenone results in increased expression of KCNJ5 mRNA

NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518

G

potassium two pore domain channel subfamily K member 15

increases expression

Zearalenone results in increased expression of KCNK15 mRNA

NCBI chr 3:152,515,237...152,521,455
Ensembl chr 3:152,515,237...152,521,455

G

potassium channel tetramerization domain containing 20

increases expression

Zearalenone results in increased expression of KCTD20 mRNA

NCBI chr20:7,015,828...7,032,766
Ensembl chr20:7,015,833...7,032,761

G

lysine demethylase 4A

decreases expression

Zearalenone results in decreased expression of KDM4A mRNA

NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501

G

KIT ligand

decreases expression

Zearalenone results in decreased expression of KITLG mRNA

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

lysine methyltransferase 5A

increases expression

Zearalenone results in increased expression of KMT5A mRNA

NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711

G

KRAS proto-oncogene, GTPase

increases expression
decreases expression

Zearalenone results in increased expression of KRAS mRNA
Zearalenone results in decreased expression of KRAS mRNA

PMID:29758222 PMID:30717214

NCBI chr 4:178,185,418...178,218,484

G

keratin 10

decreases expression

Zearalenone results in decreased expression of KRT10 protein

NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701

G

keratin 17

decreases expression

Zearalenone results in decreased expression of KRT17 mRNA

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392

G

keratin 4

decreases expression

Zearalenone results in decreased expression of KRT4 mRNA

NCBI chr 7:133,046,067...133,052,027
Ensembl chr 7:133,046,515...133,052,019

G

keratin 5

increases expression

Zearalenone results in increased expression of KRT5 mRNA

NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850

G

keratin 7

increases expression

Zearalenone results in increased expression of KRT7 mRNA

NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052

G

low density lipoprotein receptor

increases expression
decreases expression

Zearalenone results in increased expression of LDLR mRNA
Zearalenone results in decreased expression of LDLR mRNA; Zearalenone results in decreased expression of LDLR protein

PMID:32119988 PMID:32858132

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

galectin 1

decreases expression

Zearalenone results in decreased expression of LGALS1 mRNA

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

luteinizing hormone subunit beta

decreases expression
multiple interactions

Zearalenone results in decreased expression of LHB protein
Gallic Acid inhibits the reaction [Zearalenone results in decreased expression of LHB protein]

PMID:29627501 PMID:32858132 PMID:34723416

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

luteinizing hormone/choriogonadotropin receptor

multiple interactions

[Colforsin co-treated with Zearalenone] results in increased expression of LHCGR mRNA

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

LIM homeobox 8

decreases expression

Zearalenone results in decreased expression of LHX8 mRNA; Zearalenone results in decreased expression of LHX8 protein

NCBI chr 2:243,244,958...243,269,624
Ensembl chr 2:243,244,961...243,269,416

G

lamin A/C

increases expression

Zearalenone results in increased expression of LMNA protein

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

lamin B1

increases expression

Zearalenone results in increased expression of LMNB1 protein

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

LON peptidase N-terminal domain and ring finger 2

increases expression

Zearalenone results in increased expression of LONRF2 mRNA

NCBI chr 9:41,033,125...41,070,551
Ensembl chr 9:41,034,628...41,070,649

G

lipoprotein(a) like 2

increases expression

Zearalenone results in increased expression of LPAL2 mRNA

NCBI chr 4:165,207,378...165,264,321
Ensembl chr 4:165,207,328...165,264,340

G

lipin 1

increases expression
multiple interactions

Zearalenone results in increased expression of LPIN1 protein
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of LPIN1 protein]

NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097

G

leucine rich repeat containing 4

decreases expression

Zearalenone results in decreased expression of LRRC4 mRNA

NCBI chr 4:57,433,518...57,437,114
Ensembl chr 4:57,433,428...57,437,911

G

lymphocyte-specific protein 1

decreases expression

Zearalenone results in decreased expression of LSP1 mRNA

NCBI chr 1:197,614,677...197,648,414
Ensembl chr 1:197,614,687...197,648,416

G

Ly1 antibody reactive

increases expression

Zearalenone results in increased expression of LYAR mRNA

NCBI chr14:72,576,878...72,590,854
Ensembl chr14:72,576,879...72,590,612

G

MAK16 homolog

increases expression

Zearalenone results in increased expression of RBM13 mRNA

NCBI chr16:60,972,699...60,981,250
Ensembl chr16:60,972,697...60,983,243

G

microtubule-associated protein 1 light chain 3 alpha

increases expression

Zearalenone results in increased expression of MAP1LC3A mRNA

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

microtubule-associated protein 1 light chain 3 beta

increases expression

Zearalenone results in increased expression of MAP1LC3B protein

PMID:31586597 PMID:32858132 PMID:34537261

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 1

decreases expression

Zearalenone results in decreased expression of MAP2K1 protein

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 4

decreases expression
multiple interactions
increases expression

Zearalenone results in decreased expression of MAP2K4 protein
scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein]

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

mitogen activated protein kinase 1

decreases phosphorylation
multiple interactions
increases phosphorylation

Zearalenone results in decreased phosphorylation of MAPK1 protein
HERPUD1 protein promotes the reaction [Zearalenone results in decreased phosphorylation of MAPK1 protein]; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased phosphorylation of MAPK1 protein]; Zearalenone results in decreased expression of and results in decreased phosphorylation of MAPK1 protein

PMID:30394307 PMID:32858132 PMID:34716709 PMID:38159578

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 13

decreases expression

Zearalenone results in decreased expression of MAPK13 mRNA

NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions
increases phosphorylation

Zearalenone results in decreased phosphorylation of MAPK3 protein
HERPUD1 protein promotes the reaction [Zearalenone results in decreased phosphorylation of MAPK3 protein]; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased phosphorylation of MAPK3 protein]

PMID:30394307 PMID:32858132 PMID:38159578

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation
increases expression

Zearalenone results in increased phosphorylation of MAPK8 protein
Zearalenone results in increased expression of MAPK8 mRNA

PMID:21767629 PMID:30717214

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MAS1 proto-oncogene, G protein-coupled receptor

increases expression

Zearalenone results in increased expression of MAS1 mRNA

NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709

G

methionine adenosyltransferase 2 non-catalytic beta subunit

decreases expression

Zearalenone results in decreased expression of MAT2B protein

NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777

G

malate dehydrogenase 2

increases expression

Zearalenone results in increased expression of MDH2 protein

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

midkine

decreases expression

Zearalenone results in decreased expression of MDK mRNA

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

mesenchyme homeobox 1

decreases expression

Zearalenone results in decreased expression of MEOX1 mRNA

NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Zearalenone results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

microfibril associated protein 2

decreases expression

Zearalenone results in decreased expression of MFAP2 mRNA

NCBI chr 5:153,312,068...153,320,266
Ensembl chr 5:153,314,711...153,320,259

G

milk fat globule EGF and factor V/VIII domain containing

decreases expression

Zearalenone results in decreased expression of MFGE8 mRNA

NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073

G

mitofusin 2

increases expression

Zearalenone results in increased expression of MFN2 mRNA

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

increases expression

Zearalenone results in increased expression of MGAT3 mRNA

NCBI chr 7:111,708,353...111,761,825
Ensembl chr 7:111,675,730...111,762,026

G

monoglyceride lipase

multiple interactions

[Zearalenone co-treated with CGA protein] results in decreased expression of MGLL protein

NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179

G

MHC I like leukocyte 1

increases expression

Zearalenone results in increased expression of MICA mRNA

NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930

G

microRNA 146b

decreases expression

Zearalenone results in decreased expression of MIR146B mRNA

NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525

G

microRNA 185

decreases expression

Zearalenone results in decreased expression of MIR185 mRNA

NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795

G

microRNA 19a

increases expression

Zearalenone results in increased expression of MIR19A mRNA

NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993

G

microRNA 200a

multiple interactions

Zearalenone results in decreased expression of and affects the secretion of MIR200A mRNA

NCBI chr 5:166,648,494...166,648,582

G

microRNA 200b

multiple interactions

Zearalenone results in decreased expression of and affects the secretion of MIR200B mRNA

NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366

G

microRNA 200c

multiple interactions

Zearalenone results in increased expression of and results in decreased secretion of MIR200C mRNA

NCBI chr 4:157,523,679...157,523,747

G

microRNA 210

decreases expression

Zearalenone results in decreased expression of MIR210 mRNA

NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454

G

microRNA 221

increases expression
multiple interactions

Zearalenone results in increased expression of MIR221 mRNA
[Zearalenone co-treated with deoxynivalenol] results in decreased expression of MIR221 mRNA

PMID:30717214 PMID:35090964

NCBI chr X:3,429,465...3,429,573
Ensembl chr X:3,429,465...3,429,573

G

microRNA 301a

decreases expression

Zearalenone results in decreased expression of MIR301 mRNA

NCBI chr10:71,925,336...71,925,435
Ensembl chr10:71,925,336...71,925,435

G

microRNA 326

decreases expression

Zearalenone results in decreased expression of MIR326 mRNA

NCBI chr 1:153,854,029...153,854,123
Ensembl chr 1:153,854,029...153,854,123

G

microRNA 410

decreases expression

Zearalenone results in decreased expression of MIR410 mRNA

NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434

G

microRNA 411

decreases expression

Zearalenone results in decreased expression of MIR411 mRNA

NCBI chr 6:128,723,189...128,723,264
Ensembl chr 6:128,723,184...128,723,279

G

microRNA 429

decreases secretion

Zearalenone results in decreased secretion of MIR429 mRNA

NCBI chr 5:166,647,459...166,647,543
Ensembl chr 5:166,647,459...166,647,543

G

microRNA 451a

increases expression

Zearalenone results in increased expression of MIR451A mRNA

NCBI chr10:62,961,520...62,961,591
Ensembl chr10:62,961,520...62,961,591

G

microRNA 615

decreases expression

Zearalenone results in decreased expression of MIR615 mRNA

NCBI chr 7:134,151,887...134,151,978
Ensembl chr 7:134,151,887...134,151,978

G

microRNA 96

affects expression

Zearalenone affects the expression of MIR96 mRNA

NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516

G

marker of proliferation Ki-67

increases expression

Zearalenone results in increased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mutL homolog 1

increases expression

Zearalenone results in increased expression of MLH1 mRNA; Zearalenone results in increased expression of MLH1 protein

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

melanophilin

increases expression

Zearalenone results in increased expression of MLPH mRNA

NCBI chr 9:91,507,410...91,542,984
Ensembl chr 9:91,507,591...91,542,983

G

matrix metallopeptidase 2

increases expression

Zearalenone results in increased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 7

increases expression

Zearalenone results in increased expression of MMP7 mRNA

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

myeloperoxidase

multiple interactions
increases secretion
increases activity

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased activity of MPO protein]]; [Dextran Sulfate co-treated with Zearalenone] results in increased secretion of MPO protein; corynoline inhibits the reaction [Zearalenone results in increased activity of MPO protein]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased secretion of MPO protein]
Zearalenone results in increased secretion of MPO protein
Gallic Acid inhibits the reaction [Zearalenone results in increased activity of MPO protein]

PMID:30270565 PMID:34723416 PMID:36161741

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

microseminoprotein, beta

increases expression

Zearalenone results in increased expression of MSMB mRNA

NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123

G

mitochondrially encoded ATP synthase membrane subunit 6

decreases expression
multiple interactions

Zearalenone results in decreased expression of ATP6 mRNA
[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of ATP6 mRNA

NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599

G

mitochondrially encoded ATP synthase membrane subunit 8

multiple interactions

[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of ATP8 mRNA; [Plant Extracts co-treated with Zearalenone] results in decreased expression of ATP8 mRNA; [Zearalenone co-treated with ochratoxin A] results in decreased expression of ATP8 mRNA

NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961

G

mitochondrially encoded cytochrome c oxidase I

decreases expression
multiple interactions

Zearalenone results in decreased expression of COX1 mRNA
[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of COX1 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in decreased expression of COX1 mRNA; [Plant Extracts co-treated with Zearalenone] results in decreased expression of COX1 mRNA; [Zearalenone co-treated with ochratoxin A] results in decreased expression of COX1 mRNA

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mitochondrially encoded cytochrome c oxidase III

multiple interactions
decreases expression

[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of COX3 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in decreased expression of COX3 mRNA; [Plant Extracts co-treated with Zearalenone] results in decreased expression of COX3 mRNA; [Zearalenone co-treated with ochratoxin A] results in decreased expression of COX3 mRNA
Zearalenone results in decreased expression of COX3 mRNA

NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2

multiple interactions

[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in increased expression of ND2 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in increased expression of ND2 mRNA; [Plant Extracts co-treated with Zearalenone] results in increased expression of ND2 mRNA; [Zearalenone co-treated with ochratoxin A] results in increased expression of ND2 mRNA

NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3

multiple interactions

[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in increased expression of ND3 mRNA; [Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in increased expression of ND3 mRNA; [Plant Extracts co-treated with Zearalenone] results in increased expression of ND3 mRNA; [Zearalenone co-treated with ochratoxin A] results in increased expression of ND3 mRNA

NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4

decreases expression
multiple interactions

Zearalenone results in decreased expression of ND4 mRNA
[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone co-treated with beauvericin] results in decreased expression of ND4 mRNA; [Plant Extracts co-treated with Zearalenone] results in increased expression of ND4 mRNA

NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L

multiple interactions

[Plant Extracts co-treated with Zearalenone] results in increased expression of ND4L mRNA; [Zearalenone co-treated with ochratoxin A] results in increased expression of ND4L mRNA

NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
Ensembl chr MT:9,870...10,166

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5

multiple interactions

[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in increased expression of ND5 mRNA; [Plant Extracts co-treated with Zearalenone] results in increased expression of ND5 mRNA; [Zearalenone co-treated with ochratoxin A] results in increased expression of ND5 mRNA

NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

decreases expression
multiple interactions

Zearalenone results in decreased expression of ND6 mRNA
[Plant Extracts co-treated with ochratoxin A co-treated with Zearalenone] results in increased expression of ND6 mRNA; [Plant Extracts co-treated with Zearalenone] results in increased expression of ND6 mRNA; [Zearalenone co-treated with ochratoxin A] results in increased expression of ND6 mRNA

NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061

G

mitochondrial amidoxime reducing component 2

increases expression

Zearalenone results in increased expression of MTARC2 protein

NCBI chr13:96,362,810...96,397,284

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

increases expression

Zearalenone results in increased expression of MTHFD1L protein

NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905

G

mechanistic target of rapamycin kinase

decreases phosphorylation
multiple interactions

Zearalenone results in decreased phosphorylation of MTOR protein
2-aminoethyl diphenylborinate inhibits the reaction [Zearalenone results in decreased phosphorylation of MTOR protein]; acadesine promotes the reaction [Zearalenone results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Zearalenone results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Zearalenone results in decreased phosphorylation of MTOR protein]

PMID:31586597 PMID:31982503 PMID:32858132

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

mucin 2, oligomeric mucus/gel-forming

multiple interactions

[Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased expression of MUC2 mRNA; [Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased secretion of MUC2 protein; [Aflatoxin M1 co-treated with Zearalenone] results in decreased expression of MUC2 mRNA; [Aflatoxin M1 co-treated with Zearalenone] results in decreased secretion of MUC2 protein

NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756

G

mucin 4, cell surface associated

increases expression

Zearalenone results in increased expression of MUC4 mRNA

NCBI chr11:68,008,245...68,053,242

G

mucin 5AC, oligomeric mucus/gel-forming

increases expression
multiple interactions

Zearalenone results in increased expression of MUC5AC mRNA
[Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased expression of MUC5AC mRNA; [Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in increased secretion of MUC5AC protein; [Aflatoxin M1 co-treated with Zearalenone] results in decreased expression of MUC5AC mRNA; Zearalenone results in increased expression of and results in increased secretion of MUC5AC protein

PMID:24496642 PMID:30904571

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

mucin 5B, oligomeric mucus/gel-forming

multiple interactions
increases expression

[Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased expression of MUC5B mRNA; [Aflatoxin M1 co-treated with Zearalenone co-treated with ochratoxin A] results in decreased secretion of MUC5B protein; [Aflatoxin M1 co-treated with Zearalenone] results in decreased expression of MUC5B mRNA; [Aflatoxin M1 co-treated with Zearalenone] results in decreased secretion of MUC5B protein; Zearalenone results in increased expression of and results in increased secretion of MUC5B protein
Zearalenone results in increased expression of MUC5B mRNA

PMID:24496642 PMID:30904571

NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250

G

MYC proto-oncogene, bHLH transcription factor

increases expression

Zearalenone results in increased expression of MYC mRNA
Zearalenone results in increased expression of MYC protein

PMID:27473017 PMID:28965971 PMID:36828454

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYD88, innate immune signal transduction adaptor

increases expression

Zearalenone results in increased expression of MYD88 mRNA

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

Nedd4 binding protein 3

decreases expression

Zearalenone results in decreased expression of N4BP3 mRNA

NCBI chr10:35,898,031...35,906,704
Ensembl chr10:35,899,096...35,907,001

G

N(alpha)-acetyltransferase 10, NatA catalytic subunit

decreases expression

Zearalenone results in decreased expression of NAA10 protein

NCBI chr X:151,656,056...151,661,304
Ensembl chr X:151,656,056...151,661,252

G

asparaginyl-tRNA synthetase 1

decreases expression

Zearalenone results in decreased expression of NARS1 protein

NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622

G

nuclear autoantigenic sperm protein

decreases expression

Zearalenone results in decreased expression of NASP mRNA

NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928

G

noncompact myelin associated protein

increases expression

Zearalenone results in increased expression of NCMAP mRNA

NCBI chr 5:147,608,042...147,623,266
Ensembl chr 5:147,610,677...147,618,775

G

nuclear receptor coactivator 2

multiple interactions

Zearalenone analog promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone analog promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [ESR1 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]; Zearalenone promotes the reaction [NCOA2 protein binds to ESR1 protein]

PMID:15084758 PMID:28807876

NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451

G

natural killer cell cytotoxicity receptor 3 ligand 1

increases expression

Zearalenone results in increased expression of NCR3LG1 mRNA

NCBI chr 1:96,565,664...96,581,825
Ensembl chr 1:96,574,455...96,580,466

G

N-myc downstream regulated 1

decreases expression

Zearalenone results in decreased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

nectin cell adhesion molecule 4

decreases expression

Zearalenone results in decreased expression of NECTIN4 mRNA

NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709

G

nei-like DNA glycosylase 2

increases expression

Zearalenone results in increased expression of NEIL2 mRNA

NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863

G

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions

Zearalenone results in increased expression of NFE2L2 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline promotes the reaction [Zearalenone results in increased expression of NFE2L2 protein]]; corynoline promotes the reaction [Zearalenone results in increased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

increases phosphorylation
multiple interactions

Zearalenone results in increased phosphorylation of NFKBIA protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of NFKBIA protein]]; corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of NFKBIA protein]

PMID:31586597 PMID:36161741

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

neuronal guanine nucleotide exchange factor

decreases expression

Zearalenone results in decreased expression of NGEF mRNA

NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914

G

niban apoptosis regulator 2

decreases expression

Zearalenone results in decreased expression of NIBAN2 mRNA

NCBI chr 3:16,174,674...16,224,293
Ensembl chr 3:16,174,659...16,224,293

G

NLR family, pyrin domain containing 3

increases expression
multiple interactions

Zearalenone results in increased expression of NLRP3 mRNA; Zearalenone results in increased expression of NLRP3 protein
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 protein; Dextran Sulfate inhibits the reaction [Zearalenone results in increased expression of NLRP3 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 protein]
NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]; NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]

PMID:30270565 PMID:31586597

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

Zearalenone results in increased expression of NME1 mRNA

NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408

G

nicotinamide nucleotide adenylyltransferase 1

decreases expression

Zearalenone results in decreased expression of NMNAT1 mRNA

NCBI chr 5:159,910,242...159,928,201
Ensembl chr 5:159,910,242...159,928,180

G

nicotinamide nucleotide adenylyltransferase 2

decreases expression

Zearalenone results in decreased expression of NMNAT2 mRNA

NCBI chr13:65,105,950...65,277,350
Ensembl chr13:65,105,950...65,278,484

G

NmrA like redox sensor 1

decreases expression

Zearalenone results in decreased expression of NMRAL1 protein

NCBI chr10:10,841,693...10,850,199
Ensembl chr10:10,841,799...10,850,192

G

NOBOX oogenesis homeobox

decreases expression

Zearalenone results in decreased expression of NOBOX mRNA

NCBI chr 4:72,128,931...72,134,436
Ensembl chr 4:72,128,931...72,134,436

G

notch receptor 1

multiple interactions

[Zearalenone co-treated with Aflatoxin B1] results in increased expression of NOTCH1 mRNA

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

neuropeptide Y receptor Y1

increases expression

Zearalenone results in increased expression of NPY1R mRNA

NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759

G

nuclear receptor subfamily 1, group H, member 3

increases expression

Zearalenone results in increased expression of NR1H3 mRNA

PMID:32119988 PMID:38159578

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

nuclear receptor subfamily 1, group I, member 2

increases activity
decreases expression
multiple interactions
affects binding

Zearalenone results in increased activity of NR1I2 protein
Zearalenone results in decreased expression of NR1I2 mRNA
Zearalenone binds to and results in increased activity of NR1I2 protein; Zearalenone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4]
Zearalenone binds to NR1I2 protein

PMID:15569515 PMID:20607812 PMID:33049310 PMID:36893891

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

increases activity

Zearalenone results in increased activity of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

Zearalenone results in decreased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 1

decreases expression
multiple interactions
increases expression

Zearalenone results in decreased expression of NR4A1 protein
Colforsin promotes the reaction [Zearalenone results in increased expression of NR4A1 mRNA]

PMID:24512812 PMID:26783879

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 5, group A, member 1

decreases expression

Zearalenone results in decreased expression of NR5A1 mRNA; Zearalenone results in decreased expression of NR5A1 protein

NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328

G

nuclear receptor interacting protein 1

increases expression

Zearalenone results in increased expression of NRIP1 mRNA

NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761

G

neurturin

increases expression

Zearalenone results in increased expression of NRTN mRNA

NCBI chr 9:1,581,860...1,587,835
Ensembl chr 9:1,581,975...1,583,102

G

5', 3'-nucleotidase, cytosolic

decreases expression

Zearalenone results in decreased expression of NT5C protein

NCBI chr10:100,739,591...100,742,276
Ensembl chr10:100,739,588...100,741,954

G

NUBP iron-sulfur cluster assembly factor 2

decreases expression

Zearalenone results in decreased expression of NUBP2 protein

NCBI chr10:13,903,224...13,906,928
Ensembl chr10:13,903,224...13,906,969

G

nucleobindin 2

increases expression

Zearalenone results in increased expression of NUCB2 protein

NCBI chr 1:170,750,830...170,787,356
Ensembl chr 1:170,750,877...170,787,353

G

NudC domain containing 2

decreases expression

Zearalenone results in decreased expression of NUDCD2 protein

NCBI chr10:25,163,247...25,168,738
Ensembl chr10:25,163,220...25,168,738

G

nudix hydrolase 5

decreases expression

Zearalenone results in decreased expression of NUDT5 protein

NCBI chr17:72,435,690...72,459,008
Ensembl chr17:72,435,697...72,459,001

G

nucleoredoxin-like 2

increases expression

Zearalenone results in increased expression of NXNL2 mRNA

NCBI chr17:14,031,151...14,035,897
Ensembl chr17:14,031,153...14,036,189

G

odontogenesis associated phosphoprotein

decreases expression

Zearalenone results in decreased expression of ODAPH mRNA

NCBI chr14:16,071,835...16,080,151
Ensembl chr14:16,073,058...16,080,129

G

olfactomedin 1

increases expression

Zearalenone results in increased expression of OLFM1 mRNA

PMID:19371625 PMID:36828454

NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239

G

olfactomedin-like 3

increases expression

Zearalenone results in increased expression of OLFML3 mRNA

PMID:19371625 PMID:36828454

NCBI chr 2:191,244,221...191,247,050
Ensembl chr 2:191,244,221...191,247,050

G

oxidative stress induced growth inhibitor 1

multiple interactions
increases expression

[Zearalenone co-treated with ochratoxin A] results in increased expression of OSGIN1 mRNA
Zearalenone results in increased expression of OSGIN1 mRNA

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

G

oxidative stress responsive kinase 1

decreases expression

Zearalenone results in decreased expression of OXSR1 protein

NCBI chr 8:118,972,754...119,062,102
Ensembl chr 8:118,972,754...119,062,027

G

prolyl 4-hydroxylase subunit beta

multiple interactions

[Zearalenone co-treated with CGA protein] results in decreased expression of P4HB protein

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

platelet-activating factor acetylhydrolase 1b, catalytic subunit 2

decreases expression

Zearalenone results in decreased expression of PAFAH1B2 protein

NCBI chr 8:46,260,069...46,312,073
Ensembl chr 8:46,261,064...46,279,833

G

platelet-activating factor acetylhydrolase 1b, catalytic subunit 3

decreases expression

Zearalenone results in decreased expression of PAFAH1B3 protein

NCBI chr 1:80,881,263...80,883,789
Ensembl chr 1:80,881,309...80,883,893

G

phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

decreases expression

Zearalenone results in decreased expression of PAICS protein

NCBI chr14:31,199,086...31,232,731
Ensembl chr14:31,173,541...31,232,635

G

p21 (RAC1) activated kinase 2

decreases expression

Zearalenone results in decreased expression of PAK2 protein

NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816

G

paralemmin 3

decreases expression

Zearalenone results in decreased expression of PALM3 mRNA

NCBI chr19:24,121,984...24,126,079
Ensembl chr19:24,122,239...24,130,448

G

poly (ADP-ribose) polymerase 1

increases cleavage
decreases expression
increases expression
multiple interactions

Zearalenone results in increased cleavage of PARP1 protein
Zearalenone results in decreased expression of PARP1 protein
Zearalenone results in increased expression of PARP1 mRNA
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of PARP1 mRNA]

PMID:24530352 PMID:28089945 PMID:38159578

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

polysaccharide biosynthesis domain containing 1

decreases expression

Zearalenone results in decreased expression of PBDC1 protein

NCBI chr X:70,154,106...70,197,827
Ensembl chr X:70,154,106...70,184,552

G

pyruvate carboxylase

increases expression
decreases expression

Zearalenone results in increased expression of PCX protein
Zearalenone results in decreased expression of PC mRNA; Zearalenone results in decreased expression of PC protein

PMID:25058043 PMID:32858132

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

increases expression

Zearalenone results in increased expression of PCK2 protein

NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283

G

PCNA clamp associated factor

decreases expression

Zearalenone results in decreased expression of PCLAF mRNA

NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994

G

programmed cell death 1

increases expression

Zearalenone results in increased expression of PDCD1 mRNA

NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937

G

programmed cell death 6 interacting protein

multiple interactions

[Zearalenone co-treated with CGA protein] results in increased expression of PDCD6IP protein

NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773

G

programmed cell death 7

increases expression

Zearalenone results in increased expression of PDCD7 mRNA

NCBI chr 8:65,862,606...65,877,333
Ensembl chr 8:65,862,387...65,877,333

G

phosphodiesterase 3B

increases expression

Zearalenone results in increased expression of PDE3B mRNA

NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334

G

platelet-derived growth factor receptor-like

increases expression

Zearalenone results in increased expression of PDGFRL mRNA

NCBI chr16:51,347,929...51,407,850
Ensembl chr16:51,347,948...51,407,850

G

pyruvate dehydrogenase E1 subunit alpha 1

increases expression

Zearalenone results in increased expression of PDHA1 protein

NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311

G

pyridoxal-dependent decarboxylase domain containing 1

decreases expression

Zearalenone results in decreased expression of PDXDC1 protein

NCBI chr10:2,025,056...2,113,712
Ensembl chr10:2,025,360...2,113,520

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

decreases expression

Zearalenone results in decreased expression of PFKFB2 mRNA

NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699

G

phosphofructokinase, liver type

decreases expression

Zearalenone results in decreased expression of PFKL protein

NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315

G

phosphogluconate dehydrogenase

decreases expression

Zearalenone results in decreased expression of PGD protein

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

G

phosphoglycerate kinase 1

decreases expression
multiple interactions

Zearalenone results in decreased expression of PGK1 protein
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in decreased expression of PGK1 protein]

PMID:25058043 PMID:36252740 PMID:38159578

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

pyroglutamyl-peptidase I

decreases expression

Zearalenone results in decreased expression of PGPEP1 protein

NCBI chr16:18,770,563...18,782,968
Ensembl chr16:18,771,021...18,783,478

G

progesterone receptor

increases expression
multiple interactions

Zearalenone results in increased expression of PGR mRNA; Zearalenone results in increased expression of PGR protein
deoxynivalenol promotes the reaction [Zearalenone results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [Zearalenone results in increased expression of PGR protein]; PPARG inhibits the reaction [Zearalenone results in increased expression of PGR mRNA]; Zearalenone inhibits the reaction [Progesterone binds to and results in increased activity of PGR protein]

PMID:19371625 PMID:21803136 PMID:28807876 PMID:28965971 PMID:35588983

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

prohibitin 1

increases expression

Zearalenone results in increased expression of PHB1 protein

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

prohibitin 2

increases expression

Zearalenone results in increased expression of PHB2 protein

NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272

G

PHD finger protein 11

decreases expression

Zearalenone results in decreased expression of PHF11 mRNA

NCBI chr15:33,390,290...33,414,647
Ensembl chr15:33,390,292...33,413,009

G

phosphoglycerate dehydrogenase

multiple interactions
decreases expression

[Zearalenone co-treated with CGA protein] results in increased expression of PHGDH protein
Zearalenone results in decreased expression of PHGDH protein

PMID:25058043 PMID:36252740

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

increases expression

Zearalenone results in increased expression of PIK3CD mRNA

NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930

G

Pim-1 proto-oncogene, serine/threonine kinase

increases expression

Zearalenone results in increased expression of PIM1 mRNA

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

pipecolic acid and sarcosine oxidase

increases expression

Zearalenone results in increased expression of PIPOX mRNA

NCBI chr10:62,769,874...62,783,484
Ensembl chr10:62,769,900...62,782,370

G

piwi-like RNA-mediated gene silencing 1

decreases expression

Zearalenone results in decreased expression of PIWIL1 protein

NCBI chr12:27,949,743...27,970,645
Ensembl chr12:27,949,744...27,970,580

G

protein kinase domain containing, cytoplasmic

increases expression

Zearalenone results in increased expression of PKDCC mRNA

NCBI chr 6:11,455,686...11,465,002
Ensembl chr 6:11,455,686...11,465,556

G

plasminogen activator, tissue type

increases expression

Zearalenone results in increased expression of PLAT mRNA

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

phospholipase C beta 1

increases expression

Zearalenone results in increased expression of PLCB1 mRNA

PMID:19371625 PMID:36828454

NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869

G

phospholipase C, eta 1

increases expression

Zearalenone results in increased expression of PLCH1 protein

NCBI chr 2:148,148,908...148,363,616
Ensembl chr 2:148,148,921...148,364,097

G

plasminogen

increases expression

Zearalenone results in increased expression of PLG mRNA

NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786

G

perilipin 1

increases expression

Zearalenone results in increased expression of PLIN1 protein

NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828

G

phospholipid phosphatase related 2

increases expression

Zearalenone results in increased expression of PLPPR2 mRNA

NCBI chr 8:20,467,071...20,479,474
Ensembl chr 8:20,467,071...20,479,474

G

plexin domain containing 2

increases expression

Zearalenone results in increased expression of PLXDC2 mRNA

NCBI chr17:79,169,238...79,594,279
Ensembl chr17:79,196,369...79,585,282

G

phosphomannomutase 2

decreases expression

Zearalenone results in decreased expression of PMM2 protein

NCBI chr10:6,961,521...6,982,913
Ensembl chr10:6,961,709...6,983,098

G

patatin-like phospholipase domain containing 2

multiple interactions
increases expression

Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of PNPLA2 protein]

NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805

G

RNA polymerase II subunit C

increases expression

Zearalenone results in increased expression of POLR2C mRNA

NCBI chr19:10,158,153...10,164,935
Ensembl chr19:10,157,823...10,164,945

G

POU class 2 homeobox 3

decreases expression

Zearalenone results in decreased expression of POU2F3 mRNA

NCBI chr 8:43,495,408...43,577,795
Ensembl chr 8:43,495,527...43,577,795

G

inorganic pyrophosphatase 1

decreases expression

Zearalenone results in decreased expression of PPA1 protein

NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215

G

peroxisome proliferator activated receptor alpha

increases expression

Zearalenone results in increased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

increases expression
multiple interactions

Zearalenone results in increased expression of PPARD mRNA
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of PPARD mRNA]

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

decreases activity
increases expression
decreases methylation
multiple interactions

Zearalenone results in decreased activity of PPARG protein
Zearalenone results in increased expression of PPARG mRNA; Zearalenone results in increased expression of PPARG protein
Zearalenone results in decreased methylation of PPARG promoter
PPARG inhibits the reaction [Zearalenone results in increased expression of PGR mRNA]; PPARG inhibits the reaction [Zearalenone results in increased expression of TFF1 mRNA]
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of PPARG mRNA]

PMID:27481073 PMID:32119988 PMID:35588983 PMID:38159578

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 beta

increases expression

Zearalenone results in increased expression of PPARGC1B mRNA

NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194

G

protein phosphatase 1, regulatory (inhibitor) subunit 1A

increases expression

Zearalenone results in increased expression of PPP1R1A mRNA

NCBI chr 7:134,654,578...134,662,236
Ensembl chr 7:134,654,579...134,662,230

G

PR/SET domain 14

increases expression

Zearalenone results in increased expression of PRDM14 mRNA

NCBI chr 5:6,082,163...6,092,712
Ensembl chr 5:6,082,442...6,092,712

G

prolyl endopeptidase

decreases expression

Zearalenone results in decreased expression of PREP protein

NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466

G

proline rich protein HaeIII subfamily 1

decreases expression

Zearalenone results in decreased expression of PRH1 mRNA

NCBI chr 4:166,543,755...166,547,614

G

protein kinase AMP-activated catalytic subunit alpha 2

increases expression

Zearalenone results in increased expression of PRKAA2 mRNA

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

protein kinase cAMP-dependent type II regulatory subunit alpha

increases expression

Zearalenone results in increased expression of PRKAR2A mRNA

NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628

G

protein arginine methyltransferase 6

increases expression

Zearalenone results in increased expression of PRMT6 mRNA

NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648

G

phosphoribosyl pyrophosphate synthetase 2

decreases expression

Zearalenone results in decreased expression of PRPS2 protein

NCBI chr X:26,975,915...27,013,184
Ensembl chr X:26,976,061...27,013,181

G

serine protease 23

increases expression

Zearalenone results in increased expression of PRSS23 mRNA

NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091

G

prune exopolyphosphatase 1

decreases expression

Zearalenone results in decreased expression of PRUNE1 protein

NCBI chr 2:182,830,575...182,859,972
Ensembl chr 2:182,830,578...182,859,336

G

proteasome 26S subunit, ATPase 1

decreases expression

Zearalenone results in decreased expression of PSMC1 protein

NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123

G

proteasome 26S subunit, ATPase 2

decreases expression

Zearalenone results in decreased expression of PSMC2 protein

NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185

G

proteasome 26S subunit, ATPase 3

decreases expression

Zearalenone results in decreased expression of PSMC3 protein

NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358

G

proteasome 26S subunit, ATPase 4

decreases expression

Zearalenone results in decreased expression of PSMC4 protein

NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494

G

proteasome 26S subunit, non-ATPase 13

decreases expression

Zearalenone results in decreased expression of PSMD13 protein

NCBI chr 1:195,964,617...195,976,895
Ensembl chr 1:195,964,138...195,976,905

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 2

decreases expression

Zearalenone results in decreased expression of PSMD2 protein

NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043

G

proteasome assembly chaperone 2

decreases expression

Zearalenone results in decreased expression of PSMG2 protein

NCBI chr18:61,208,669...61,227,671
Ensembl chr18:61,208,678...61,259,816

G

phosphatase and tensin homolog

increases expression
decreases expression

Zearalenone results in increased expression of PTEN mRNA
Zearalenone results in decreased expression of PTEN protein

PMID:27473017 PMID:30717214

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin E synthase 3

decreases expression

Zearalenone results in decreased expression of PTGES3 protein

NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084

G

prostaglandin reductase 2

decreases expression

Zearalenone results in decreased expression of PTGR2 protein

NCBI chr 6:103,931,367...103,963,113
Ensembl chr 6:103,931,409...103,963,111

G

prostaglandin-endoperoxide synthase 2

increases expression

Zearalenone results in increased expression of PTGS2 mRNA

PMID:27757495 PMID:36828454

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

decreases expression

Zearalenone results in decreased expression of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

pseudouridine synthase 7

increases expression

Zearalenone results in increased expression of PUS7 mRNA

NCBI chr 4:11,360,169...11,401,139
Ensembl chr 4:11,360,188...11,401,172

G

PYD and CARD domain containing

increases expression
multiple interactions

Zearalenone results in increased expression of PYCARD mRNA; Zearalenone results in increased expression of PYCARD protein
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of PYCARD mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of PYCARD protein; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of PYCARD mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of PYCARD protein]
[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of PYCARD protein

PMID:30270565 PMID:31586597

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

RAB20, member RAS oncogene family

decreases expression

Zearalenone results in decreased expression of RAB20 mRNA

NCBI chr16:78,019,337...78,043,529
Ensembl chr16:78,019,337...78,043,529

G

receptor for activated C kinase 1

increases expression

Zearalenone results in increased expression of RACK1 mRNA; Zearalenone results in increased expression of RACK1 protein

NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975

G

RAD51 recombinase

decreases expression
increases expression

Zearalenone results in decreased expression of RAD51 mRNA
Zearalenone results in increased expression of RAD51 mRNA; Zearalenone results in increased expression of RAD51 protein

PMID:27862621 PMID:28552778 PMID:35650142

NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035

G

Raf-1 proto-oncogene, serine/threonine kinase

increases expression

Zearalenone results in increased expression of RAF1 mRNA

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAN binding protein 1

decreases expression

Zearalenone results in decreased expression of RANBP1 protein

NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838

G

RAP1A, member of RAS oncogene family

decreases expression

Zearalenone results in decreased expression of RAP1A mRNA

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

RAP1B, member of RAS oncogene family

decreases expression

Zearalenone results in decreased expression of RAP1B mRNA

NCBI chr 7:53,423,039...53,456,349
Ensembl chr 7:53,423,130...53,456,370

G

Rap guanine nucleotide exchange factor 4

increases expression

Zearalenone results in increased expression of RAPGEF4 mRNA

NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316

G

retinoic acid receptor, beta

decreases expression

Zearalenone results in decreased expression of RARB mRNA

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

arginyl-tRNA synthetase 1

decreases expression

Zearalenone results in decreased expression of RARS1 protein

NCBI chr10:20,270,744...20,295,192
Ensembl chr10:20,270,483...20,295,196

G

RAS guanyl releasing protein 1

increases expression

Zearalenone results in increased expression of RASGRP1 mRNA

NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056

G

Ras association domain family member 1

increases expression

Zearalenone results in increased expression of RASSF1 mRNA

NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164

G

Ras association domain family member 2

decreases expression

Zearalenone results in decreased expression of RASSF2 mRNA

NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431

G

RB binding protein 8, endonuclease

increases expression

Zearalenone results in increased expression of RBBP8 mRNA

NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846

G

RBBP8 N-terminal like

decreases expression

Zearalenone results in decreased expression of RBBP8NL mRNA

NCBI chr 3:167,364,048...167,378,993
Ensembl chr 3:167,364,048...167,379,092

G

RNA binding motif protein 24

increases expression

Zearalenone results in increased expression of RBM24 mRNA

NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102

G

retinol binding protein 1

decreases expression

Zearalenone results in decreased expression of RBP1 mRNA

NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743

G

REL proto-oncogene, NF-kB subunit

decreases expression

Zearalenone results in decreased expression of REL protein

NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases phosphorylation

3-methyladenine promotes the reaction [Zearalenone results in increased phosphorylation of and affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Zearalenone results in increased phosphorylation of and affects the localization of RELA protein]; Sirolimus inhibits the reaction [Zearalenone results in increased phosphorylation of and affects the localization of RELA protein]; Zearalenone results in increased phosphorylation of and affects the localization of RELA protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of RELA protein]]; corynoline inhibits the reaction [Zearalenone results in increased phosphorylation of RELA protein]

PMID:31586597 PMID:36161741

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

riboflavin kinase

decreases expression

Zearalenone results in decreased expression of RFK protein

NCBI chr 1:214,799,880...214,807,440
Ensembl chr 1:214,799,825...214,807,438
Ensembl chr X:214,799,825...214,807,438

G

Rho-related BTB domain containing 1

increases expression

Zearalenone results in increased expression of RHOBTB1 mRNA

NCBI chr20:19,327,142...19,456,121
Ensembl chr20:19,327,155...19,403,012

G

RIB43A domain with coiled-coils 2

decreases expression

Zearalenone results in decreased expression of RIBC2 mRNA

NCBI chr 7:116,242,863...116,257,868
Ensembl chr 7:116,242,863...116,257,863

G

regulating synaptic membrane exocytosis 4

increases expression

Zearalenone results in increased expression of RIMS4 mRNA

NCBI chr 3:152,520,982...152,585,070
Ensembl chr 3:152,524,095...152,584,780

G

receptor interacting serine/threonine kinase 1

increases expression
multiple interactions

Zearalenone results in increased expression of RIPK1 mRNA; Zearalenone results in increased expression of RIPK1 protein
RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]; scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 mRNA]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 protein]

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

RecQ mediated genome instability 2

decreases expression

Zearalenone results in decreased expression of RMI2 mRNA

NCBI chr10:4,829,333...4,837,264
Ensembl chr10:4,830,553...4,837,235

G

ring finger protein 224

decreases expression

Zearalenone results in decreased expression of RNF224 mRNA

NCBI chr 3:8,050,088...8,052,416
Ensembl chr 3:8,051,475...8,051,945

G

ribonuclease/angiogenin inhibitor 1

decreases expression

Zearalenone results in decreased expression of RNH1 protein

PMID:25058043 PMID:36252740

NCBI chr 1:196,269,293...196,281,763
Ensembl chr 1:196,269,293...196,281,910

G

replication protein A3

decreases expression

Zearalenone results in decreased expression of RPA3 protein

NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709

G

ribosomal protein L14

decreases expression

Zearalenone results in decreased expression of RPL14 mRNA

NCBI chr 8:120,286,035...120,289,160
Ensembl chr 8:120,284,645...120,289,064

G

ribosomal protein L23A

decreases expression

Zearalenone results in decreased expression of RPL23A mRNA

NCBI chr10:63,076,660...63,079,346
Ensembl chr10:63,076,066...63,079,346
Ensembl chr15:63,076,066...63,079,346

G

ribosomal protein S23

decreases expression

Zearalenone results in decreased expression of RPS23 protein

NCBI chr 2:22,079,339...22,080,909
Ensembl chr 2:22,079,302...22,080,918

G

ribosomal protein S3

decreases expression

Zearalenone results in decreased expression of RPS3 protein

NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680

G

ribosomal protein S5

decreases expression

Zearalenone results in decreased expression of RPS5 mRNA

NCBI chr 1:73,538,776...73,543,073
Ensembl chr 1:73,538,776...73,543,073

G

ribosomal protein S6

decreases expression

Zearalenone results in decreased expression of RPS6 protein

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

multiple interactions
decreases phosphorylation

2-aminoethyl diphenylborinate inhibits the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]; acadesine promotes the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]; Acetylcysteine inhibits the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]; dorsomorphin inhibits the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]; HERPUD1 protein inhibits the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]

PMID:30394307 PMID:31982503

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

ribosomal protein S8

decreases expression

Zearalenone results in decreased expression of RPS8 mRNA

NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268

G

Ras-related GTP binding B

decreases expression

Zearalenone results in decreased expression of RRAGB mRNA

NCBI chr X:18,184,619...18,234,639
Ensembl chr X:18,184,992...18,234,639

G

ribosome biogenesis regulator 1 homolog

increases expression

Zearalenone results in increased expression of RRS1 mRNA

NCBI chr 5:9,733,486...9,735,119
Ensembl chr 5:9,733,091...9,735,140

G

rubicon like autophagy enhancer

increases expression

Zearalenone results in increased expression of RUBCNL mRNA

NCBI chr15:50,332,458...50,377,494
Ensembl chr15:50,332,418...50,400,849

G

S100 calcium binding protein A6

decreases expression

Zearalenone results in decreased expression of S100A6 protein

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

S100 calcium binding protein G

increases expression

Zearalenone results in increased expression of S100G mRNA

NCBI chr X:31,705,853...31,708,422
Ensembl chr X:31,705,866...31,708,433

G

sphingosine-1-phosphate receptor 3

increases expression

Zearalenone results in increased expression of S1PR3 mRNA

NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505

G

SUMO1 activating enzyme subunit 1

decreases expression

Zearalenone results in decreased expression of SAE1 protein

NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986

G

SAMM50 sorting and assembly machinery component

increases expression

Zearalenone results in increased expression of SAMM50 protein

NCBI chr 7:115,317,472...115,341,682
Ensembl chr 7:115,317,404...115,341,682

G

secretion associated, Ras related GTPase 1A

decreases expression

Zearalenone results in decreased expression of SAR1A protein

NCBI chr20:29,623,529...29,635,935
Ensembl chr20:29,623,553...29,635,935

G

spermidine/spermine N1-acetyl transferase 1

decreases expression

Zearalenone results in decreased expression of SAT1 mRNA

NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813

G

stearoyl-CoA desaturase

increases expression
multiple interactions

Zearalenone results in increased expression of SCD1 mRNA
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of SCD1 mRNA]

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

SEC31 homolog A, COPII coat complex component

decreases expression

Zearalenone results in decreased expression of SEC31A protein

NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273

G

Serpine1 mRNA binding protein 1

decreases expression

Zearalenone results in decreased expression of SERBP1 protein

NCBI chr 4:96,401,587...96,421,816
Ensembl chr 4:96,401,477...96,421,813

G

serpin family E member 1

multiple interactions

[Zearalenone co-treated with Aflatoxin B1] results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

seizure related 6 homolog

increases expression

Zearalenone results in increased expression of SEZ6 mRNA

NCBI chr10:62,818,931...62,868,686
Ensembl chr10:62,819,069...62,868,671

G

splicing factor 3b, subunit 5

increases expression

Zearalenone results in increased expression of SF3B5 mRNA

NCBI chr 1:7,357,040...7,357,752
Ensembl chr 1:7,350,731...7,357,839

G

surfactant protein D

increases expression

Zearalenone results in increased expression of SFTPD mRNA

NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927

G

siah E3 ubiquitin protein ligase 1

decreases expression

Zearalenone results in decreased expression of SIAH1 mRNA

NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808

G

sirtuin 1

decreases expression
multiple interactions
increases expression

Zearalenone results in decreased expression of SIRT1 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in decreased expression of SIRT1 protein]]; corynoline inhibits the reaction [Zearalenone results in decreased expression of SIRT1 protein]; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of SIRT1 mRNA]

PMID:36161741 PMID:38159578

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 12, member 8

multiple interactions
decreases expression

Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in decreased expression of SLC12A8 mRNA]

NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834

G

solute carrier family 19 member 2

increases expression

Zearalenone results in increased expression of SLC19A2 mRNA

NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172

G

solute carrier family 1 member 5

increases expression
decreases expression

Zearalenone results in increased expression of SLC1A5 mRNA
Zearalenone results in decreased expression of SLC1A5 mRNA; Zearalenone results in decreased expression of SLC1A5 protein

PMID:19371625 PMID:32858132

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 22 member 3

increases expression

Zearalenone results in increased expression of SLC22A3 mRNA

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 26 member 9

decreases expression

Zearalenone results in decreased expression of SLC26A9 mRNA

NCBI chr13:43,177,806...43,205,450
Ensembl chr13:43,177,867...43,204,330

G

solute carrier family 2 member 2

increases expression

Zearalenone results in increased expression of SLC2A2 mRNA

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 31 member 1

increases expression

Zearalenone results in increased expression of SLC31A1 mRNA

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

solute carrier family 37 member 2

increases expression

Zearalenone results in increased expression of SLC37A2 protein

NCBI chr 8:36,945,787...36,971,748
Ensembl chr 8:36,946,930...36,971,482

G

solute carrier family 38, member 1

decreases expression

Zearalenone results in decreased expression of SLC38A1 mRNA; Zearalenone results in decreased expression of SLC38A1 protein

NCBI chr 7:127,733,230...127,802,541
Ensembl chr 7:127,738,226...127,802,218

G

solute carrier family 39 member 6

increases expression

Zearalenone results in increased expression of SLC39A6 mRNA

NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417

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solute carrier family 3 member 2

increases expression

Zearalenone results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

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solute carrier family 41, member 3

decreases expression

Zearalenone results in decreased expression of SLC41A3 mRNA

NCBI chr 4:123,109,555...123,154,766
Ensembl chr 4:123,112,748...123,154,766

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solute carrier family 6 member 15

increases expression

Zearalenone results in increased expression of SLC6A15 mRNA

NCBI chr 7:38,553,055...38,607,239
Ensembl chr 7:38,553,196...38,607,239

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solute carrier family 6 member 6

increases expression

Zearalenone results in increased expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

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solute carrier family 7 member 11

increases expression

Zearalenone results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

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solute carrier family 7 member 2

increases expression

Zearalenone results in increased expression of SLC7A2 mRNA

NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784

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solute carrier family 7 member 5

increases expression

Zearalenone results in increased expression of SLC7A5 mRNA

PMID:19371625 PMID:36828454

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

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solute carrier organic anion transporter family, member 1a4

decreases activity

Zearalenone results in decreased activity of SLCO1A2 protein

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

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solute carrier organic anion transporter family member 1B2

decreases activity

Zearalenone results in decreased activity of SLCO1B3 protein

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

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solute carrier organic anion transporter family, member 2b1

decreases activity

Zearalenone results in decreased activity of SLCO2B1 protein

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

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slit guidance ligand 2

decreases expression

Zearalenone results in decreased expression of SLIT2 mRNA

NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948

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SLIT and NTRK-like family, member 4

increases expression

Zearalenone results in increased expression of SLITRK4 mRNA

NCBI chr X:142,706,495...142,718,968
Ensembl chr X:142,706,338...142,718,575

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SMAD family member 3

increases expression
multiple interactions

Zearalenone results in increased expression of SMAD3 mRNA
[Tamoxifen co-treated with Zearalenone] results in increased expression of SMAD3 mRNA

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

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sphingomyelin phosphodiesterase, acid-like 3B

multiple interactions

[Zearalenone co-treated with CGA protein] results in decreased expression of SMPDL3B protein

NCBI chr 5:144,944,618...144,966,703
Ensembl chr 5:144,944,636...144,966,720

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snail family transcriptional repressor 2

decreases expression

Zearalenone results in decreased expression of SNAI2 mRNA

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

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superoxide dismutase 1

decreases expression
multiple interactions

Zearalenone results in decreased expression of SOD1 mRNA; Zearalenone results in decreased expression of SOD1 protein
Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in decreased expression of SOD1 protein]

PMID:32858132 PMID:38159578

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

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superoxide dismutase 2

decreases expression
multiple interactions

Zearalenone results in decreased expression of SOD2 mRNA; Zearalenone results in decreased expression of SOD2 protein
[Nicotinamide Mononucleotide co-treated with Zearalenone] results in decreased expression of SOD2 mRNA

PMID:32858132 PMID:38159578

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

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spermatogenesis and oogenesis specific basic helix-loop-helix 2

decreases expression

Zearalenone results in decreased expression of SOHLH2 mRNA

NCBI chr 2:139,362,246...139,384,700
Ensembl chr 2:139,362,246...139,384,699

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SRY-box transcription factor 9

decreases expression

Zearalenone results in decreased expression of SOX9 mRNA

NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994

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spermatogenesis associated 2

decreases expression

Zearalenone results in decreased expression of SPATA2 mRNA

NCBI chr 3:156,202,962...156,213,283
Ensembl chr 3:156,202,967...156,211,705

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splA/ryanodine receptor domain and SOCS box containing 3

decreases expression

Zearalenone results in decreased expression of SPSB3 mRNA

NCBI chr10:13,907,175...13,912,841
Ensembl chr10:13,907,253...13,912,841

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squalene epoxidase

decreases expression

Zearalenone results in decreased expression of SQLE mRNA

PMID:19371625 PMID:25424538

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

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sequestosome 1

increases expression
decreases expression

Zearalenone results in increased expression of SQSTM1 protein
Zearalenone results in decreased expression of SQSTM1 mRNA; Zearalenone results in decreased expression of SQSTM1 protein

PMID:31586597 PMID:31982503 PMID:32858132 PMID:34537261

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

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steroid 5 alpha-reductase 1

decreases expression
decreases activity

Zearalenone results in decreased expression of SRD5A1 mRNA
Zearalenone results in decreased activity of SRD5A1 protein

NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461

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sterol regulatory element binding transcription factor 1

increases expression

Zearalenone results in increased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

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sulfiredoxin 1

decreases expression
multiple interactions

Zearalenone results in decreased expression of SRXN1 mRNA
[Plant Extracts co-treated with Zearalenone] results in decreased expression of SRXN1 mRNA; [Zearalenone co-treated with ochratoxin A] results in decreased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

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scavenger receptor cysteine rich family member with 4 domains

decreases expression

Zearalenone results in decreased expression of SSC4D mRNA

NCBI chr12:20,702,931...20,723,732
Ensembl chr12:20,702,950...20,718,706

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SSU72 homolog, RNA polymerase II CTD phosphatase

decreases expression

Zearalenone results in decreased expression of SSU72 protein

NCBI chr 5:166,312,267...166,343,432
Ensembl chr 5:166,313,650...166,343,429

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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

decreases expression

Zearalenone results in decreased expression of ST8SIA1 mRNA

NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708

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steroidogenic acute regulatory protein

multiple interactions
increases expression
decreases expression

Colforsin affects the reaction [Zearalenone results in increased expression of STAR mRNA]
Zearalenone results in decreased expression of STAR mRNA; Zearalenone results in decreased expression of STAR protein

PMID:24512812 PMID:26783879 PMID:29627501

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

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signal transducer and activator of transcription 5A

decreases expression

Zearalenone results in decreased expression of STAT5A mRNA

NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866

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serine threonine kinase 31

decreases expression

Zearalenone results in decreased expression of STK31 protein

NCBI chr 4:78,370,691...78,467,599
Ensembl chr 4:78,370,649...78,466,240

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stomatin like 2

increases expression

Zearalenone results in increased expression of STOML2 protein

NCBI chr 5:57,256,227...57,259,824
Ensembl chr 5:57,256,220...57,259,920

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stimulated by retinoic acid 8

decreases expression

Zearalenone results in decreased expression of STRA8 mRNA

NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771

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serine/threonine kinase receptor associated protein

decreases expression

Zearalenone results in decreased expression of STRAP protein

NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828

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sulfotransferase family 1E member 1

decreases activity

Zearalenone results in decreased activity of SULT1E1 protein

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

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synapse associated protein 1

multiple interactions

[Zearalenone co-treated with CGA protein] results in decreased expression of SYAP1 protein

NCBI chr X:31,792,180...31,826,672
Ensembl chr X:31,792,193...31,826,667

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synaptonemal complex protein 1

increases expression

Zearalenone results in increased expression of SYCP1 mRNA

NCBI chr 2:190,296,688...190,456,687
Ensembl chr 2:190,296,954...190,456,737

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synaptonemal complex protein 3

decreases expression

Zearalenone results in decreased expression of SYCP3 mRNA; Zearalenone results in decreased expression of SYCP3 protein

PMID:24412631 PMID:28552778 PMID:31419471

NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511

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synaptotagmin binding, cytoplasmic RNA interacting protein

decreases expression

Zearalenone results in decreased expression of SYNCRIP protein

NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515

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transaldolase 1

decreases expression

Zearalenone results in decreased expression of TALDO1 protein

NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974

G

tubulin folding cofactor E-like

decreases expression

Zearalenone results in decreased expression of TBCEL protein

NCBI chr 8:42,795,648...42,854,552
Ensembl chr 8:42,796,730...42,854,552

G

TEA domain transcription factor 3

increases expression

Zearalenone results in increased expression of TEAD3 mRNA

NCBI chr20:6,392,053...6,411,446
Ensembl chr20:6,392,053...6,411,446

G

transferrin

decreases expression
multiple interactions
affects expression

Zearalenone results in decreased expression of TF mRNA
[deoxynivalenol co-treated with Zearalenone] affects the expression of TF mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of TF mRNA
Zearalenone affects the expression of TF mRNA

PMID:28865950 PMID:28935499

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

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transcription factor AP-4

increases expression

Zearalenone results in increased expression of TFAP4 mRNA

NCBI chr10:11,001,338...11,019,386
Ensembl chr10:11,002,911...11,019,386

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trefoil factor 1

multiple interactions
increases expression

deoxynivalenol promotes the reaction [Zearalenone results in increased expression of TFF1 mRNA]; PPARG inhibits the reaction [Zearalenone results in increased expression of TFF1 mRNA]

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

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trefoil factor 3

increases expression

Zearalenone results in increased expression of TFF3 mRNA

NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054

G

transforming growth factor alpha

increases expression

Zearalenone results in increased expression of TGFA mRNA

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

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transforming growth factor, beta 2

decreases expression

Zearalenone results in decreased expression of TGFB2 mRNA

PMID:27862621 PMID:29758222

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

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transglutaminase 1

decreases expression

Zearalenone results in decreased expression of TGM1 mRNA

NCBI chr15:29,191,039...29,206,000
Ensembl chr15:29,191,041...29,204,523

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tyrosine hydroxylase

decreases expression

Zearalenone results in decreased expression of TH mRNA

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

thrombospondin 1

increases expression
decreases expression

Zearalenone results in increased expression of THBS1 mRNA
Zearalenone results in decreased expression of THBS1 mRNA

PMID:19371625 PMID:28965971

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

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thyroid hormone receptor alpha

multiple interactions

Zearalenone binds to and results in increased activity of THRA protein

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

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thyroid hormone receptor beta

multiple interactions
decreases activity

[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of THRB protein; Zearalenone inhibits the reaction [Triiodothyronine results in increased activity of THRB protein]
Zearalenone results in decreased activity of THRB protein

PMID:27481073 PMID:31077750

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

translocase of inner mitochondrial membrane 17A

increases expression

Zearalenone results in increased expression of TIMM17A protein

NCBI chr13:46,731,117...46,742,604
Ensembl chr13:46,730,660...46,742,655

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TERF1 interacting nuclear factor 2

decreases expression

Zearalenone results in decreased expression of TINF2 mRNA

NCBI chr15:29,170,663...29,178,015
Ensembl chr15:29,170,652...29,176,984

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transketolase

decreases expression

Zearalenone results in decreased expression of TKT protein

NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698

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talin 1

multiple interactions

[Zearalenone co-treated with CGA protein] results in increased expression of TLN1 protein

NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900

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toll-like receptor 3

increases expression

Zearalenone results in increased expression of TLR3 mRNA

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

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transmembrane 6 superfamily member 1

increases expression

Zearalenone results in increased expression of TM6SF1 mRNA

NCBI chr 1:135,799,844...135,828,515
Ensembl chr 1:135,786,381...135,828,443

G

transmembrane protein 121

decreases expression

Zearalenone results in decreased expression of TMEM121 mRNA

NCBI chr 6:132,262,182...132,265,797
Ensembl chr 6:132,262,176...132,265,914

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transmembrane protein 215

increases expression

Zearalenone results in increased expression of TMEM215 mRNA

NCBI chr 5:55,612,568...55,615,828
Ensembl chr 5:55,612,568...55,615,828

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transmembrane protein 54

decreases expression

Zearalenone results in decreased expression of TMEM54 mRNA

NCBI chr 5:141,449,191...141,455,683
Ensembl chr 5:141,449,191...141,455,682

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tumor necrosis factor

multiple interactions
increases expression

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [corynoline inhibits the reaction [Zearalenone results in increased expression of TNF protein]]; corynoline inhibits the reaction [Zearalenone results in increased expression of TNF protein]; Lipopolysaccharides promotes the reaction [Zearalenone results in increased expression of TNF mRNA]; Lycopene inhibits the reaction [Zearalenone results in increased expression of TNF]; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of TNF mRNA]
Zearalenone results in increased expression of TNF; Zearalenone results in increased expression of TNF mRNA; Zearalenone results in increased expression of TNF protein
3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; [Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein; Gallic Acid inhibits the reaction [Zearalenone results in increased expression of TNF protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; NLRP3 protein promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Zearalenone results in increased expression of TNF protein]; Sirolimus inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]
[Lipopolysaccharides co-treated with Zearalenone] results in increased secretion of TNF protein

PMID:16687389 PMID:25682699 PMID:31586597 PMID:32328699 PMID:34723416 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

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TNF receptor superfamily member 25

decreases expression

Zearalenone results in decreased expression of TNFRSF25 mRNA

NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341

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TNF superfamily member 10

increases expression

Zearalenone results in increased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

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troponin T1, slow skeletal type

decreases expression

Zearalenone results in decreased expression of TNNT1 mRNA

NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721

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translocase of outer mitochondrial membrane 40

increases expression

Zearalenone results in increased expression of TOMM40 protein

NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915

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translocase of outer mitochondrial membrane 70

increases expression

Zearalenone results in increased expression of TOMM70A protein

NCBI chr11:43,378,719...43,417,166
Ensembl chr11:43,377,216...43,417,202

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tumor protein p53

decreases expression
increases expression
multiple interactions

Zearalenone results in decreased expression of TRP53 mRNA; Zearalenone results in decreased expression of TRP53 protein
Zearalenone results in increased expression of TP53 mRNA
[Zearalenone co-treated with Aflatoxin B1] promotes the reaction [deoxynivalenol results in increased expression of TP53 mRNA]
crocin inhibits the reaction [Zearalenone results in increased expression of TRP53 protein]

PMID:24412631 PMID:26231423 PMID:27473017 PMID:30668976

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

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tumor protein p73

multiple interactions

[Zearalenone co-treated with Aflatoxin B1] results in increased expression of TP73 mRNA

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128