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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor
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Accession:CHEBI:76902 term browser browse the term
Definition:An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the function of any such enzyme using 2-oxoglutarate as one donor and incorporating one atom each of oxygen into both donors (EC 1.14.11.*).
Synonyms:related_synonym: EC 1.14.11.* inhibitor;   EC 1.14.11.* inhibitors;   oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors (EC 1.14.11.*) inhibitors;   oxidoreductase acting on paired donors, with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (EC 1.14.11.*) inhibitor;   oxidoreductase acting on paired donors, with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (EC 1.14.11.*) inhibitors


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3,4-dihydroxybenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) multiple interactions ISO protocatechuic acid inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased activity of ACHE protein]		 CTD PMID:32392679 PMID:33497687 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in increased expression of AKR1B1 mRNA] CTD PMID:22687555 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284 		JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP Gallic Acid inhibits the reaction [protocatechuic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]]; protocatechuic acid inhibits the reaction [APP protein modified form binds to APP protein modified form] CTD PMID:22129351 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G ASS1 argininosuccinate synthase 1 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of ASS1 mRNA] CTD PMID:37105472 NCBI chr 9:130,444,707...130,501,274
Ensembl chr 9:130,444,961...130,501,274 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of BAX protein]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of BAX mRNA]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of BAX protein]		 CTD PMID:32392679 PMID:33497687 PMID:36593721 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 mRNA]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; protocatechuic acid inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of BCL2 mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]		 CTD PMID:18082360 PMID:32392679 PMID:33497687 PMID:36593721 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions ISO protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of BDNF protein]		 CTD PMID:32392679 PMID:33497687 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 mRNA]; protocatechuic acid inhibits the reaction [furan results in increased activity of CASP3 protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased activity of CASP3 protein]; protocatechuic acid inhibits the reaction [Rotenone results in increased activity of CASP3 protein]
protocatechuic acid inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]		 CTD PMID:18082360 PMID:32392679 PMID:32758512 PMID:33497687 PMID:36593721 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 multiple interactions ISO protocatechuic acid inhibits the reaction [furan results in increased activity of CASP9 protein] CTD PMID:32758512 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase increases activity
multiple interactions		 ISO protocatechuic acid results in increased activity of CAT protein
protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of CAT mRNA]; protocatechuic acid inhibits the reaction [furan results in decreased activity of CAT protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]
protocatechuic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of CAT protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]		 CTD PMID:29842870 PMID:32392679 PMID:32758512 PMID:33497687 PMID:36593721 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:31306686 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression ISO protocatechuic acid results in increased expression of CDKN1A protein CTD PMID:16227210 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397 		JBrowse link
G COMT catechol-O-methyltransferase increases methylation EXP
ISO		 COMT protein results in increased methylation of protocatechuic acid CTD PMID:11160877 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
G CS citrate synthase increases activity ISO protocatechuic acid results in increased activity of CS protein CTD PMID:31306686 NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of CYP11A1 mRNA]; protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of CYP11A1 protein] CTD PMID:37105472 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of CYP17A1 mRNA] CTD PMID:37105472 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of CYP19A1 mRNA] CTD PMID:37105472 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO protocatechuic acid inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein] CTD PMID:15302093 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO protocatechuic acid inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein] CTD PMID:15302093 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
decreases activity		 ISO [protocatechuic acid co-treated with Methylcholanthrene] results in decreased activity of CYP2E1 protein; protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of CYP2E1 mRNA]
protocatechuic acid results in decreased activity of CYP2E1 protein		 CTD PMID:15302093 PMID:37105472 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of CYP7B1 mRNA] CTD PMID:37105472 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737 		JBrowse link
G DKK2 dickkopf WNT signaling pathway inhibitor 2 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of DKK2 mRNA] CTD PMID:37105472 NCBI chr 4:106,921,802...107,036,313
Ensembl chr 4:106,921,802...107,283,806 		JBrowse link
G EFNA2 ephrin A2 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of EFNA2 mRNA] CTD PMID:37105472 NCBI chr19:1,284,227...1,301,431
Ensembl chr19:1,285,873...1,301,431 		JBrowse link
G ENO1 enolase 1 increases expression EXP protocatechuic acid results in increased expression of ENO1 mRNA CTD PMID:16227210 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190 		JBrowse link
G EPO erythropoietin multiple interactions
increases expression		 ISO protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of EPO protein]; protocatechuic acid inhibits the reaction [Methylmercury Compounds results in decreased expression of EPO protein]
protocatechuic acid results in increased expression of EPO protein		 CTD PMID:31850806 PMID:32461003 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A binds to ESR1 protein] CTD PMID:37105472 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A binds to ESR2 protein] CTD PMID:37105472 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FSHB follicle stimulating hormone subunit beta increases expression
multiple interactions		 ISO protocatechuic acid results in increased expression of FSHB protein
protocatechuic acid inhibits the reaction [furan results in decreased expression of FSHB protein]		 CTD PMID:29842870 PMID:32758512 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases activity
multiple interactions		 ISO protocatechuic acid results in increased activity of G6PD protein
protocatechuic acid inhibits the reaction [furan results in decreased activity of G6PD protein]		 CTD PMID:29842870 PMID:32758512 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G GLO1 glyoxalase I multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in decreased expression of and results in decreased activity of GLO1 protein] CTD PMID:22687555 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145 		JBrowse link
G GPX1 glutathione peroxidase 1 increases expression
multiple interactions		 ISO protocatechuic acid results in increased expression of GPX1 mRNA
protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of GPX1 mRNA]
protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]		 CTD PMID:32392679 PMID:33497687 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GSR glutathione-disulfide reductase increases expression
multiple interactions
increases activity		 ISO protocatechuic acid results in increased expression of GSR mRNA
protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of GSR mRNA]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]
protocatechuic acid results in increased activity of GSR protein
protocatechuic acid inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of GSR mRNA]		 CTD PMID:32392679 PMID:33497687 PMID:36593721 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases stability
increases expression
multiple interactions		 ISO protocatechuic acid results in increased stability of HIF1A protein
protocatechuic acid results in increased expression of HIF1A protein
protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; protocatechuic acid inhibits the reaction [Methylmercury Compounds results in decreased expression of HIF1A protein]		 CTD PMID:16227210 PMID:31850806 PMID:32461003 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 ISO protocatechuic acid inhibits the reaction [Isoproterenol results in decreased expression of HMOX1 mRNA]
protocatechuic acid results in increased expression of HMOX1 mRNA		 CTD PMID:36593721 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HSD17B11 hydroxysteroid 17-beta dehydrogenase 11 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of HSD17B11 mRNA] CTD PMID:37105472 NCBI chr 4:87,336,515...87,391,188
Ensembl chr 4:87,336,515...87,391,188 		JBrowse link
G HSD17B3 hydroxysteroid 17-beta dehydrogenase 3 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of HSD17B3 mRNA] CTD PMID:37105472 NCBI chr 9:96,235,306...96,302,176
Ensembl chr 9:96,235,306...96,302,176 		JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 mRNA] CTD PMID:37105472 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054 		JBrowse link
G HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of HSD3B2 mRNA] CTD PMID:37105472 NCBI chr 1:119,414,931...119,423,034
Ensembl chr 1:119,414,931...119,423,035 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IKBKB protein] CTD PMID:36807594 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO protocatechuic acid inhibits the reaction [furan results in decreased expression of IL10 protein] CTD PMID:32758512 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in increased secretion of IL1B protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]; protocatechuic acid inhibits the reaction [furan results in increased expression of IL1B protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]		 CTD PMID:22687555 PMID:32392679 PMID:32758512 PMID:33497687 PMID:36593721 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:22687555 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G LDHC lactate dehydrogenase C increases activity ISO protocatechuic acid results in increased activity of LDHC protein CTD PMID:29842870 NCBI chr11:18,412,318...18,452,063
Ensembl chr11:18,412,318...18,452,063 		JBrowse link
G LHB luteinizing hormone subunit beta increases expression
multiple interactions		 ISO protocatechuic acid results in increased expression of LHB protein
protocatechuic acid inhibits the reaction [furan results in decreased expression of LHB protein]		 CTD PMID:29842870 PMID:32758512 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein] CTD PMID:36807594 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein] CTD PMID:36807594 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MPO myeloperoxidase increases activity
multiple interactions
decreases activity		 EXP
ISO		 protocatechuic acid results in increased activity of MPO protein
protocatechuic acid inhibits the reaction [furan results in increased activity of MPO protein]
protocatechuic acid results in decreased activity of MPO protein		 CTD PMID:24060682 PMID:29842870 PMID:32758512 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO [protocatechuic acid co-treated with Cadmium Chloride] results in increased expression of NFE2L2 mRNA; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA]
protocatechuic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 mRNA]
protocatechuic acid results in increased expression of NFE2L2 mRNA		 CTD PMID:32392679 PMID:36593721 PMID:36807594 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIB NFKB inhibitor beta multiple interactions ISO protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein] CTD PMID:20026373 NCBI chr19:38,899,666...38,908,889
Ensembl chr19:38,899,700...38,908,893 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO protocatechuic acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of NOS2 mRNA]; protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 mRNA]		 CTD PMID:20026373 PMID:31306686 PMID:32392679 PMID:33497687 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases activity		 ISO [protocatechuic acid co-treated with Methylcholanthrene] results in increased activity of NQO1 protein
protocatechuic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of NQO1 mRNA]
protocatechuic acid results in increased activity of NQO1 protein		 CTD PMID:15302093 PMID:36807594 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G OXTR oxytocin receptor multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of OXTR mRNA] CTD PMID:37105472 NCBI chr 3:8,741,269...8,769,613
Ensembl chr 3:8,750,381...8,769,628 		JBrowse link
G PITX1 paired like homeodomain 1 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of PITX1 mRNA] CTD PMID:37105472 NCBI chr 5:135,027,734...135,034,789
Ensembl chr 5:135,027,734...135,034,813 		JBrowse link
G PRL prolactin multiple interactions ISO protocatechuic acid inhibits the reaction [furan results in decreased expression of PRL protein] CTD PMID:32758512 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in increased expression of PTGS2 mRNA]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of PTGS2 protein]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of PTGS2 protein]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased expression of PTGS2 protein] CTD PMID:20026373 PMID:22687555 PMID:31306686 PMID:36807594 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO protocatechuic acid inhibits the reaction [Galactose results in increased expression of and results in increased activity of RELA protein]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of RELA mRNA]; protocatechuic acid inhibits the reaction [Galactose results in increased expression of RELA protein]; protocatechuic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]
protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of RELA protein]		 CTD PMID:20026373 PMID:22687555 PMID:36593721 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SCARB1 scavenger receptor class B member 1 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of SCARB1 mRNA] CTD PMID:37105472 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668 		JBrowse link
G SELE selectin E multiple interactions EXP protocatechuic acid inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:30611791 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 increases expression
multiple interactions		 ISO protocatechuic acid results in increased expression of SLC2A1 protein
protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC2A1 protein]; protocatechuic acid inhibits the reaction [Methylmercury Compounds results in decreased expression of SLC2A1 protein]		 CTD PMID:31850806 PMID:32461003 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression
multiple interactions		 ISO protocatechuic acid results in increased expression of SOD2 mRNA
protocatechuic acid inhibits the reaction [Cadmium Chloride results in decreased expression of SOD2 mRNA]
protocatechuic acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA]		 CTD PMID:32392679 PMID:33497687 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of STAR mRNA]; protocatechuic acid inhibits the reaction [bisphenol A results in decreased expression of STAR protein] CTD PMID:37105472 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
G STMN2 stathmin 2 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of STMN2 mRNA] CTD PMID:37105472 NCBI chr 8:79,611,117...79,666,158
Ensembl chr 8:79,611,117...79,666,158 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein] CTD PMID:36593721 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:36807594 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO
EXP		 protocatechuic acid inhibits the reaction [Galactose results in increased secretion of TNF protein]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; protocatechuic acid inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; protocatechuic acid inhibits the reaction [furan results in increased expression of TNF protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of TNF protein]
protocatechuic acid inhibits the reaction [TNF protein results in increased expression of SELE protein]		 CTD PMID:22687555 PMID:30611791 PMID:31306686 PMID:32392679 PMID:32758512 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G UGT2A3 UDP glucuronosyltransferase family 2 member A3 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of UGT2A3 mRNA] CTD PMID:37105472 NCBI chr 4:68,928,463...68,951,804
Ensembl chr 4:68,928,463...68,951,804 		JBrowse link
G ULBP1 UL16 binding protein 1 multiple interactions ISO protocatechuic acid inhibits the reaction [bisphenol A results in increased expression of ULBP1 mRNA] CTD PMID:37105472 NCBI chr 6:149,963,943...149,973,715
Ensembl chr 6:149,963,943...149,973,715 		JBrowse link
G VEGFA vascular endothelial growth factor A increases expression
multiple interactions		 ISO protocatechuic acid results in increased expression of VEGFA protein
protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of VEGFA protein]; protocatechuic acid inhibits the reaction [Methylmercury Compounds results in decreased expression of VEGFA protein]		 CTD PMID:16227210 PMID:31850806 PMID:32461003 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
ethyl 3,4-dihydroxybenzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FABP4 fatty acid binding protein 4 multiple interactions ISO ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased expression of FABP4 mRNA] CTD PMID:24338020 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236 		JBrowse link
G GATA3 GATA binding protein 3 multiple interactions ISO ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased ubiquitination of and results in increased degradation of GATA3 protein] CTD PMID:24338020 NCBI chr10:8,045,333...8,075,198
Ensembl chr10:8,045,378...8,075,198 		JBrowse link
G KLF2 KLF transcription factor 2 multiple interactions ISO ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased ubiquitination of and results in increased degradation of KLF2 protein] CTD PMID:24338020 NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,826...16,328,685 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO ethyl protocatechuate inhibits the reaction [rosiglitazone results in increased expression of PPARG mRNA] CTD PMID:24338020 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G SP7 Sp7 transcription factor multiple interactions ISO ethyl protocatechuate inhibits the reaction [Ascorbic Acid results in increased expression of SP7 mRNA]; ethyl protocatechuate inhibits the reaction [Ascorbic Acid results in increased expression of SP7 protein] CTD PMID:21467157 NCBI chr12:53,326,575...53,344,793
Ensembl chr12:53,326,575...53,345,315 		JBrowse link
G TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase multiple interactions ISO ethyl protocatechuate inhibits the reaction [Rosiglitazone results in increased ubiquitination of and results in increased degradation of TAFAZZIN protein] CTD PMID:24338020 NCBI chr  X:154,411,539...154,421,726
Ensembl chr  X:154,411,524...154,421,726 		JBrowse link
meldonium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADL acyl-CoA dehydrogenase long chain increases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of ACADL mRNA CTD PMID:32389661 NCBI chr 2:210,187,923...210,225,447
Ensembl chr 2:210,187,126...210,225,447 		JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of ACADM mRNA CTD PMID:32389661 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,431...75,787,575 		JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of ACADVL mRNA CTD PMID:32389661 NCBI chr17:7,217,125...7,225,266
Ensembl chr17:7,217,125...7,225,266 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of ACOX1 mRNA CTD PMID:32389661 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177 		JBrowse link
G CPT1B carnitine palmitoyltransferase 1B decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of CPT1B mRNA CTD PMID:32389661 NCBI chr22:50,568,861...50,578,612
Ensembl chr22:50,568,861...50,578,465 		JBrowse link
G CPT1C carnitine palmitoyltransferase 1C decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of CPT1C mRNA CTD PMID:32389661 NCBI chr19:49,690,662...49,713,731
Ensembl chr19:49,690,898...49,713,731 		JBrowse link
G HK1 hexokinase 1 increases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of HK1 mRNA CTD PMID:32389661 NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884 		JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 increases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of PDK1 mRNA CTD PMID:32389661 NCBI chr 2:172,555,373...172,724,312
Ensembl chr 2:172,555,373...172,608,669 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of PPARA mRNA CTD PMID:32389661 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of PPARGC1A mRNA CTD PMID:27559315 PMID:32389661 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PPARGC1B PPARG coactivator 1 beta affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of PPARGC1B mRNA CTD PMID:27559315 NCBI chr 5:149,730,310...149,857,959
Ensembl chr 5:149,730,298...149,855,022 		JBrowse link
G SLC22A5 solute carrier family 22 member 5 increases uptake EXP
ISO		 SLC22A5 protein results in increased uptake of 3-(2,2,2-trimethylhydrazine)propionate CTD PMID:18981167 NCBI chr 5:132,369,710...132,395,612
Ensembl chr 5:132,369,710...132,395,613 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 increases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of SLC2A4 mRNA CTD PMID:32389661 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SLC5A2 solute carrier family 5 member 2 affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of SLC5A2 mRNA CTD PMID:32389661 NCBI chr16:31,483,123...31,490,769
Ensembl chr16:31,483,002...31,490,860 		JBrowse link
G TFAM transcription factor A, mitochondrial decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of TFAM mRNA CTD PMID:27559315 NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220 		JBrowse link
roxadustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG5 autophagy related 5 multiple interactions ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of ATG5 protein] CTD PMID:27082295 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791 		JBrowse link
G BNIP3 BCL2 interacting protein 3 multiple interactions ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of BNIP3 protein] CTD PMID:27082295 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases activity
multiple interactions		 EXP
ISO		 roxadustat results in increased activity of HIF1A protein
[Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [roxadustat results in increased activity of HIF1A protein]
roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of HIF1A protein]		 CTD PMID:27082295 PMID:29741670 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HK2 hexokinase 2 increases expression EXP roxadustat results in increased expression of HK2 mRNA CTD PMID:33596451 NCBI chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359 		JBrowse link
G LDHA lactate dehydrogenase A increases expression EXP roxadustat results in increased expression of LDHA mRNA CTD PMID:33596451 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions ISO roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of MAP1LC3B protein] CTD PMID:27082295 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 increases expression EXP roxadustat results in increased expression of SLC2A1 mRNA CTD PMID:33596451 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26496
    role 26318
      biological role 26297
        biochemical role 25509
          enzyme inhibitor 22377
            EC 1.* (oxidoreductase) inhibitor 19426
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 16637
                EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor 94
                  EC 1.14.11.1 (gamma-butyrobetaine dioxygenase) inhibitor + 15
                  EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor + 79
                  EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor + 7
                  GSK-LSD1 0
                  N-oxalylglycine + 0
paths to the root