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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.1.1.* (methyltransferases) inhibitor
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Accession:CHEBI:76871 term browser browse the term
Definition:An EC 2.1.* (C1-transferase) inhibitor that interferes with the action of any methyltransferase (EC 2.1.1.*).
Synonyms:related_synonym: EC 2.1.1.* (methyltransferases) inhibitors;   EC 2.1.1.* inhibitor;   EC 2.1.1.* inhibitors;   methyltransferase (EC 2.1.1.*) inhibitor;   methyltransferase (EC 2.1.1.*) inhibitors



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amodiaquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Amodiaquine analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein] CTD PMID:29614332 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein
Amodiaquine results in increased expression of BAX protein
CTD PMID:31629065 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein] CTD PMID:29614332 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein
Amodiaquine results in decreased expression of BCL2 protein
CTD PMID:31629065 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Amodiaquine results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Amodiaquine results in increased cleavage of CASP3 protein CTD PMID:31629065 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Ccnd1 cyclin D1 affects expression ISO Amodiaquine affects the expression of CCND1 protein CTD PMID:24113242 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A affects expression ISO Amodiaquine affects the expression of CDKN1A mRNA; Amodiaquine affects the expression of CDKN1A protein CTD PMID:24113242 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 multiple interactions EXP CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]] CTD PMID:29938495 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991
JBrowse link
G Ctsb cathepsin B decreases activity ISO Amodiaquine results in decreased activity of CTSB protein CTD PMID:24113242 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372
JBrowse link
G Ctsd cathepsin D decreases activity ISO Amodiaquine results in decreased activity of CTSD protein CTD PMID:24113242 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775
JBrowse link
G Ctsl cathepsin L decreases activity ISO Amodiaquine results in decreased activity of CTSL protein CTD PMID:24113242 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
multiple interactions
increases metabolic processing
decreases response to substance
ISO Amodiaquine results in increased activity of CYP1A1 protein
[CYP1A1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CYP1A1 protein results in decreased susceptibility to Amodiaquine
CTD PMID:12451431 PMID:31629065 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases metabolic processing
multiple interactions
ISO Amodiaquine results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased metabolism of Amodiaquine
[CYP1A2 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [Gemfibrozil results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine; [Trimethoprim results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine
CTD PMID:11124226 PMID:26599973 PMID:31629065 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases response to substance
increases metabolic processing
multiple interactions
ISO CYP1B1 protein results in decreased susceptibility to Amodiaquine
CYP1B1 protein results in increased metabolism of Amodiaquine
[CYP1B1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:31629065 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 multiple interactions
increases metabolic processing
ISO [CYP2A6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine CTD PMID:31629065 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases metabolic processing
multiple interactions
ISO CYP2B6 protein results in increased metabolism of Amodiaquine
[CYP2B6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:31629065 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases metabolic processing
increases response to substance
affects metabolic processing
multiple interactions
ISO CYP2C8 protein results in increased metabolism of Amodiaquine
CYP2C8 protein results in increased susceptibility to Amodiaquine
CYP2C8 protein affects the metabolism of Amodiaquine
[5-bromotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [5-chlorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [5-fluorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased abundance of and results in increased secretion of desethylamodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of desethylamodiaquine; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Tryptamines analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; Felodipine inhibits the reaction [CYP2C8 protein results in increased metabolism of Amodiaquine]; Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]
CTD PMID:12920490 PMID:15155557 PMID:15601807 PMID:15626586 PMID:15771232 More... NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity
multiple interactions
increases metabolic processing
ISO Amodiaquine results in decreased activity of CYP2C19 protein
[CYP2C19 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:11124226 PMID:31629065 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene multiple interactions
increases metabolic processing
ISO [CYP2C18 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine CTD PMID:31629065 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity ISO Amodiaquine results in decreased activity of CYP2C9 protein CTD PMID:11124226 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions
increases metabolic processing
ISO [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine CTD PMID:28478157 PMID:31629065 PMID:33259822 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases metabolic processing
ISO [CYP2E1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine CTD PMID:31629065 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 increases metabolic processing
multiple interactions
ISO CYP3A5 protein results in increased metabolism of Amodiaquine
[CYP3A5 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:31629065 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO Amodiaquine affects the expression of E2F1 mRNA; Amodiaquine affects the expression of E2F1 protein CTD PMID:24113242 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
JBrowse link
G Ereg epiregulin increases expression ISO Amodiaquine results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP [LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]] CTD PMID:29938495 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Amodiaquine results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Lag3 lymphocyte-activation gene 3 multiple interactions EXP [PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein] CTD PMID:29938495 NCBI chr 6:124,881,322...124,888,668
Ensembl chr 6:124,881,324...124,888,668
JBrowse link
G Ly6c1 lymphocyte antigen 6 family member C1 multiple interactions EXP [LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]] CTD PMID:29938495 NCBI chr15:74,915,867...74,920,690
Ensembl chr15:74,915,867...74,920,679
JBrowse link
G Ly6g lymphocyte antigen 6 family member G multiple interactions EXP [LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]] CTD PMID:29938495 NCBI chr15:75,027,110...75,030,977
Ensembl chr15:75,027,089...75,030,975
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein CTD PMID:31629065 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein CTD PMID:31629065 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein CTD PMID:31629065 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases expression
multiple interactions
ISO Amodiaquine results in decreased expression of MCL1 protein
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein
CTD PMID:31629065 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
JBrowse link
G Met met proto-oncogene increases expression ISO Amodiaquine results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
JBrowse link
G Mpo myeloperoxidase affects response to substance EXP MPO protein affects the susceptibility to Amodiaquine CTD PMID:24588327 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 multiple interactions ISO Amodiaquine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3] CTD PMID:29281794 NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO Amodiaquine binds to and results in increased activity of NR4A2 protein CTD PMID:31175960 NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015
JBrowse link
G Pdcd1 programmed cell death 1 multiple interactions EXP [PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]] CTD PMID:29938495 NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Amodiaquine results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 1:84,014,014...84,317,550
Ensembl chr 1:84,014,017...84,341,901
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Amodiaquine results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation ISO Amodiaquine affects the phosphorylation of RB1 protein CTD PMID:24113242 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]] CTD PMID:29938495 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 decreases expression ISO Amodiaquine results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698
JBrowse link
G Trp53 transformation related protein 53 increases activity
affects expression
ISO Amodiaquine results in increased activity of TP53 protein
Amodiaquine affects the expression of TP53 protein
CTD PMID:12082016 PMID:24113242 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
berberine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 increases expression EXP berberine increases expression of abca1 protein in mouse liver and human hepatocytes RGD PMID:29505790 RGD:19165131 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A increases expression ISO Berberine results in increased expression of ABCB1A mRNA CTD PMID:20410605 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression ISO Berberine results in increased expression of ABCB1B mRNA CTD PMID:20410605 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315
JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of ACADM mRNA] CTD PMID:25455889 NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269
JBrowse link
G Acan aggrecan decreases expression ISO Berberine results in decreased expression of ACAN mRNA CTD PMID:26478571 NCBI chr 7:78,702,974...78,764,847
Ensembl chr 7:78,703,231...78,764,847
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA]; Berberine inhibits the reaction [acetamiprid results in increased activity of ACHE protein]
Berberine results in decreased activity of ACHE protein
CTD PMID:29170048 PMID:33844597 PMID:37350525 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:25455889 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta decreases expression
multiple interactions
ISO
EXP
Berberine results in decreased expression of ACTA2 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of ACTA2 mRNA]
CTD PMID:17973934 PMID:37839514 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of AGER mRNA] CTD PMID:35121005 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
JBrowse link
G Ahr aryl-hydrocarbon receptor increases activity ISO Berberine results in increased activity of AHR protein CTD PMID:16046213 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO Berberine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]
Berberine results in decreased phosphorylation of AKT1 protein
Berberine inhibits the reaction [Thioacetamide results in increased phosphorylation of AKT1 protein]
Berberine results in increased phosphorylation of AKT1 protein
CTD PMID:23954465 PMID:30138605 PMID:33325633 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Akt2 thymoma viral proto-oncogene 2 multiple interactions EXP Berberine inhibits the reaction [Dexamethasone results in decreased expression of AKT2 mRNA] CTD PMID:20462044 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251
JBrowse link
G Alb albumin multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in decreased expression of ALB protein] CTD PMID:30138605 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] CTD PMID:29170048 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Berberine results in decreased expression of AURKB mRNA CTD PMID:27311644 NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490
JBrowse link
G Aurkc aurora kinase C increases expression ISO Berberine results in increased expression of AURKC mRNA CTD PMID:27311644 NCBI chr 7:6,998,346...7,006,090
Ensembl chr 7:6,998,299...7,006,090
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
ISO [Berberine co-treated with Thioacetamide] results in increased expression of BAX mRNA; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of BAX mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein]
Berberine results in increased expression of BAX mRNA; Berberine results in increased expression of BAX protein
[Berberine co-treated with Cisplatin] results in increased expression of BAX protein; [Berberine co-treated with Niacinamide] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased expression of BAX protein]; SRT1720 inhibits the reaction [Berberine results in increased expression of BAX protein]
CTD PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression
multiple interactions
ISO Berberine results in increased expression of BBC3 mRNA
[Berberine co-treated with Niacinamide] results in increased expression of BBC3 mRNA
CTD PMID:26712469 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
increases expression
multiple interactions
ISO Berberine results in decreased expression of BCL2 mRNA; Berberine results in decreased expression of BCL2 protein
Berberine results in increased expression of BCL2 protein
Berberine inhibits the reaction [Chlorpyrifos results in decreased expression of BCL2 mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of BCL2 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]
[Berberine co-treated with Cisplatin] results in decreased expression of BCL2 protein; [Berberine co-treated with Niacinamide] results in decreased expression of BCL2 protein; Berberine inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
CTD PMID:16505103 PMID:20656010 PMID:23954465 PMID:24751971 PMID:25600690 More... NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO Berberine results in decreased expression of BCL2L1 protein CTD PMID:16505103 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO [Berberine co-treated with Niacinamide] results in increased expression of BCL2L11 mRNA
Berberine results in increased expression of BCL2L11 mRNA
CTD PMID:26712469 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions ISO
EXP
Berberine inhibits the reaction [Chlorpyrifos results in decreased expression of BECN1 mRNA]
Berberine promotes the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BECN1 protein]
CTD PMID:35439518 PMID:38705399 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
JBrowse link
G Bglap bone gamma carboxyglutamate protein increases expression
multiple interactions
ISO Berberine results in increased expression of BGLAP mRNA; Berberine results in increased expression of BGLAP protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]
CTD PMID:26478571 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO Berberine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions
increases expression
ISO
EXP
[Cisplatin co-treated with Berberine] results in increased expression of BNIP3 protein
Berberine promotes the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BNIP3 protein]
Berberine results in increased expression of BNIP3 protein
CTD PMID:36070022 PMID:38705399 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
JBrowse link
G Bnip3l BCL2/adenovirus E1B interacting protein 3-like multiple interactions
increases expression
ISO [Cisplatin co-treated with Berberine] results in increased expression of BNIP3L protein; BNIP3L protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]
Berberine results in increased expression of BNIP3L protein
CTD PMID:36070022 NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326
JBrowse link
G Casp1 caspase 1 multiple interactions EXP Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of and results in increased cleavage of CASP1 protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CASP1 mRNA] CTD PMID:38705399 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
increases expression
ISO
EXP
[Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; [Berberine co-treated with Niacinamide] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein]; Berberine results in increased cleavage of and results in increased activity of CASP3 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of CASP3 protein]
Berberine increases activity of CASP3 protein in colon epithelial cells
Berberine results in increased cleavage of CASP3 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP3 mRNA; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 mRNA]; Berberine inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of CASP3 mRNA]
Berberine results in increased activity of CASP3 protein
Berberine results in increased expression of CASP3 mRNA
CTD
RGD
PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 More... RGD:152995489 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 increases activity ISO Berberine results in increased activity of CASP8 protein CTD PMID:20656010 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO
EXP
Berberine results in increased cleavage of CASP9 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of CASP9 protein]
[Berberine co-treated with Thioacetamide] results in increased expression of CASP9 mRNA
[Berberine co-treated with Niacinamide] results in increased cleavage of CASP9 protein
CTD PMID:16505103 PMID:26712469 PMID:30138605 PMID:37839514 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions ISO
EXP
Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the activity of CAT protein]; Berberine inhibits the reaction [acetamiprid results in decreased activity of CAT protein]; Berberine inhibits the reaction [Bortezomib results in decreased expression of CAT protein]; Berberine inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Berberine inhibits the reaction [Thioacetamide results in decreased activity of CAT protein]
Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of CAT protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of CAT protein]
CTD PMID:20828602 PMID:24751971 PMID:25600690 PMID:30138605 PMID:33460233 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]
Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CCL2 protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CCL2 mRNA]
CTD PMID:16391493 PMID:35691465 PMID:38705399 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO Berberine results in decreased expression of CCND1 protein
Berberine inhibits the reaction [CDK4 mRNA binds to CCND1 mRNA]
CTD PMID:16505103 PMID:33325633 PMID:36822301 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Berberine results in decreased expression of CCND2 protein CTD PMID:16505103 NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Berberine results in decreased expression of CCNE1 protein CTD PMID:16505103 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
JBrowse link
G Ccnt1 cyclin T1 multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein] CTD PMID:20828602 NCBI chr15:98,436,570...98,468,340
Ensembl chr15:98,436,570...98,468,804
JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression
ISO
EXP
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of CD36 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased expression of CD36 protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; Berberine results in increased expression of and affects the localization of CD36 protein; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
Berberine results in increased expression of CD36 mRNA; Berberine results in increased expression of CD36 protein
CTD PMID:28038998 PMID:29408570 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP Berberine inhibits the reaction [Particulate Matter results in decreased expression of CDH1 mRNA] CTD PMID:37839514 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Berberine results in decreased expression of CDH2 mRNA CTD PMID:26478571 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Berberine results in decreased expression of CDK2 protein CTD PMID:16505103 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdk4 cyclin dependent kinase 4 decreases expression
multiple interactions
ISO Berberine results in decreased expression of CDK4 protein
Berberine inhibits the reaction [CDK4 mRNA binds to CCND1 mRNA]
CTD PMID:16505103 PMID:36822301 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
JBrowse link
G Cdk6 cyclin dependent kinase 6 decreases expression ISO Berberine results in decreased expression of CDK6 protein CTD PMID:16505103 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008
JBrowse link
G Cdk9 cyclin dependent kinase 9 multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein] CTD PMID:20828602 NCBI chr 2:32,595,794...32,608,098
Ensembl chr 2:32,595,796...32,603,088
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO Berberine results in increased expression of CDKN1A protein CTD PMID:16505103 PMID:23747414 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression ISO Berberine results in increased expression of CDKN1B protein CTD PMID:16505103 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Cdkn1c cyclin dependent kinase inhibitor 1C increases expression ISO Berberine results in increased expression of CDKN1C mRNA CTD PMID:26478571 NCBI chr 7:143,012,076...143,014,735
Ensembl chr 7:143,012,076...143,014,787
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
decreases expression
EXP
ISO
Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Berberine results in decreased expression of CEBPA mRNA; Berberine results in decreased expression of CEBPA protein
CTD PMID:20564506 PMID:26478571 PMID:37511356 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta affects phosphorylation
increases expression
multiple interactions
EXP
ISO
Berberine affects the phosphorylation of CEBPB protein
Berberine results in increased expression of CEBPB mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased phosphorylation of CEBPB protein]; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
CTD PMID:28038998 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Berberine results in increased expression of CHEK1 protein modified form CTD PMID:23747414 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361
JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO Berberine results in increased expression of CHEK2 protein modified form CTD PMID:23747414 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011
JBrowse link
G Col10a1 collagen, type X, alpha 1 increases expression ISO Berberine results in increased expression of COL10A1 mRNA CTD PMID:26478571 NCBI chr10:34,265,977...34,273,081
Ensembl chr10:34,265,977...34,273,081
JBrowse link
G Col1a1 collagen, type I, alpha 1 increases expression
multiple interactions
ISO
EXP
Berberine results in increased expression of COL1A1 mRNA
Berberine inhibits the reaction [Particulate Matter results in increased expression of COL1A1 mRNA]
CTD PMID:26478571 PMID:37839514 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Col2a1 collagen, type II, alpha 1 decreases expression ISO Berberine results in decreased expression of COL2A1 mRNA CTD PMID:26478571 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576
JBrowse link
G Col3a1 collagen, type III, alpha 1 multiple interactions EXP Berberine inhibits the reaction [Particulate Matter results in increased expression of COL3A1 mRNA] CTD PMID:37839514 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 multiple interactions ISO Berberine inhibits the reaction [acetamiprid results in decreased expression of COX4I1 mRNA] CTD PMID:37350525 NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:25455889 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in decreased expression of CREB1 protein] CTD PMID:35121005 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Crebbp CREB binding protein increases expression ISO Berberine results in increased expression of CREBBP mRNA CTD PMID:27311644 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861
JBrowse link
G Cst3 cystatin C multiple interactions EXP Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CST3 protein] CTD PMID:38705399 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612
JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions
ISO Berberine results in increased expression of CTNNB1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]
CTD PMID:26478571 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Ctsd cathepsin D decreases cleavage
multiple interactions
ISO Berberine results in decreased cleavage of CTSD protein
GSK2795039 affects the reaction [Berberine results in decreased cleavage of CTSD protein]
CTD PMID:36070022 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775
JBrowse link
G Ctsl cathepsin L decreases cleavage
multiple interactions
ISO Berberine results in decreased cleavage of CTSL protein
Acetylcysteine inhibits the reaction [Berberine results in decreased cleavage of CTSL protein]; GSK2795039 affects the reaction [Berberine results in decreased cleavage of CTSL protein]
CTD PMID:36070022 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [Mustard Gas results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein] CTD PMID:16391493 PMID:28916288 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to NCF1 protein]; Berberine promotes the reaction [CYBB protein binds to NCF2 protein]; Berberine promotes the reaction [CYBB protein binds to RAC2 protein] CTD PMID:36070022 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO Berberine affects the localization of CYCS protein
[Berberine co-treated with Cisplatin] results in increased expression of CYCS protein
CTD PMID:16505103 PMID:36070022 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP17A1 mRNA] CTD PMID:20462044 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
multiple interactions
ISO
EXP
Berberine results in decreased activity of CYP1A1 protein
Berberine results in increased expression of CYP1A1 mRNA
Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
CTD PMID:16046213 PMID:22342832 PMID:24583342 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA] CTD PMID:22342832 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
increases expression
EXP Berberine inhibits the reaction [Streptozocin results in increased expression of CYP2B10 mRNA]; Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]
Berberine results in increased expression of CYP2B10 mRNA
CTD PMID:22342832 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 multiple interactions
increases expression
EXP Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B9 mRNA]; Berberine promotes the reaction [Streptozocin results in increased expression of CYP2B9 mRNA]
Berberine results in increased expression of CYP2B9 mRNA
CTD PMID:22342832 NCBI chr 7:25,872,775...25,910,086
Ensembl chr 7:25,872,836...25,910,086
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions
EXP Berberine results in decreased expression of CYP2E1 mRNA
Berberine inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]
CTD PMID:22342832 PMID:25455889 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions
decreases expression
EXP Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP3A11 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP3A11 mRNA]
Berberine results in decreased expression of CYP3A11 mRNA
CTD PMID:22342832 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774
JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 multiple interactions
decreases expression
EXP Berberine inhibits the reaction [Clofibrate results in increased expression of CYP4A10 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP4A10 mRNA]
Berberine results in decreased expression of CYP4A10 mRNA
CTD PMID:22342832 NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846
JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 multiple interactions
decreases expression
EXP Berberine inhibits the reaction [Clofibrate results in increased expression of CYP4A14 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP4A14 mRNA]
Berberine results in decreased expression of CYP4A14 mRNA
CTD PMID:22342832 NCBI chr 4:115,343,397...115,353,355
Ensembl chr 4:115,343,397...115,353,339
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein] CTD PMID:26478571 NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO Berberine results in decreased expression of DNMT1 mRNA CTD PMID:27311644 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
JBrowse link
G Dnmt3b DNA methyltransferase 3B decreases expression ISO Berberine results in decreased expression of DNMT3B mRNA CTD PMID:27311644 NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650
JBrowse link
G Dzip3 DAZ interacting protein 3, zinc finger increases expression ISO Berberine results in increased expression of DZIP3 mRNA CTD PMID:27311644 NCBI chr16:48,744,591...48,814,505
Ensembl chr16:48,744,595...48,814,528
JBrowse link
G Egf epidermal growth factor multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein] CTD PMID:33325633 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Berberine results in decreased expression of EGFR protein CTD PMID:33325633 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Berberine results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein CTD PMID:23363784 NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702
JBrowse link
G Ep300 E1A binding protein p300 increases expression ISO Berberine results in increased expression of EP300 mRNA CTD PMID:27311644 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Berberine results in decreased expression of ERBB2 protein]; Berberine results in decreased expression of and results in increased ubiquitination of ERBB2 protein CTD PMID:33325633 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Berberine inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Berberine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr19:6,888,345...6,899,182
Ensembl chr19:6,888,345...6,899,208
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression
increases expression
multiple interactions
ISO
EXP
Berberine results in decreased expression of FABP4 mRNA
Berberine results in increased expression of FABP4 mRNA
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of FABP4 mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of FABP4 mRNA]
CTD PMID:26478571 PMID:29408570 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
EXP
ISO
[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA; Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA]
Berberine results in increased expression of FAS mRNA; Berberine results in increased expression of FAS protein
CTD PMID:20564506 PMID:20656010 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fasl Fas ligand increases expression ISO Berberine results in increased expression of FASLG mRNA; Berberine results in increased expression of FASLG protein CTD PMID:20656010 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP
Berberine inhibits the reaction [Thioacetamide results in increased expression of FN1 mRNA]
Berberine inhibits the reaction [Particulate Matter results in increased expression of FN1 mRNA]
CTD PMID:30138605 PMID:37839514 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO1 protein; Berberine results in increased expression of and results in increased acetylation of FOXO1 protein CTD PMID:26712469 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein; Berberine results in increased expression of and results in increased acetylation of FOXO3 protein CTD PMID:26712469 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
JBrowse link
G Fundc1 FUN14 domain containing 1 increases expression
multiple interactions
ISO Berberine results in increased expression of FUNDC1 protein
[Cisplatin co-treated with Berberine] results in increased expression of FUNDC1 protein; FUNDC1 protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]
CTD PMID:36070022 NCBI chr  X:17,386,206...17,438,600
Ensembl chr  X:17,422,803...17,438,564
JBrowse link
G Gata2 GATA binding protein 2 increases expression EXP Berberine results in increased expression of GATA2 mRNA CTD PMID:37511356 NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014
JBrowse link
G Gata3 GATA binding protein 3 increases expression EXP Berberine results in increased expression of GATA3 mRNA CTD PMID:37511356 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of GCLC mRNA] CTD PMID:35121005 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of GCLM mRNA] CTD PMID:35121005 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gdf5 growth differentiation factor 5 decreases expression ISO Berberine results in decreased expression of GDF5 mRNA CTD PMID:26478571 NCBI chr 2:155,782,943...155,787,204
Ensembl chr 2:155,782,943...155,787,287
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of GFAP mRNA] CTD PMID:35121005 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP
ISO
Berberine inhibits the reaction [Ethanol results in increased activity of GPT protein]
Berberine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Berberine inhibits the reaction [Thioacetamide results in increased activity of GPT protein]
CTD PMID:24751971 PMID:25455889 PMID:30138605 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of GPX1 mRNA] CTD PMID:24751971 PMID:33460233 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
EXP
ISO
Berberine inhibits the reaction [Dexamethasone results in decreased expression of GSK3B mRNA]
Berberine results in increased phosphorylation of GSK3B protein
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]
CTD PMID:20462044 PMID:23954465 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gsr glutathione reductase multiple interactions ISO Berberine inhibits the reaction [Chlorpyrifos results in decreased activity of GSR protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein] CTD PMID:24751971 PMID:25600690 PMID:33460233 PMID:35439518 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G H2ac10 H2A clustered histone 10 decreases expression ISO Berberine results in decreased expression of H2AC14 mRNA CTD PMID:27311644 NCBI chr13:23,718,045...23,718,548
Ensembl chr13:23,718,076...23,718,474
JBrowse link
G H2ac12 H2A clustered histone 12 decreases expression ISO Berberine results in decreased expression of H2AC12 mRNA CTD PMID:27311644 NCBI chr13:22,219,292...22,219,813
Ensembl chr13:22,219,334...22,219,738
JBrowse link
G H2ac13 H2A clustered histone 13 decreases expression ISO Berberine results in decreased expression of H2AC8 mRNA CTD PMID:27311644 NCBI chr13:21,900,582...21,901,029
Ensembl chr13:21,900,592...21,900,984
JBrowse link
G H2ac18 H2A clustered histone 18 decreases expression ISO Berberine results in decreased expression of H2AC18 mRNA CTD PMID:27311644 NCBI chr 3:96,152,853...96,153,439
Ensembl chr 3:96,152,813...96,153,398
JBrowse link
G H2ac22 H2A clustered histone 22 decreases expression ISO Berberine results in decreased expression of H2AC11 mRNA CTD PMID:27311644 NCBI chr13:21,970,944...21,971,418
Ensembl chr13:21,970,996...21,971,388
JBrowse link
G H2ac25 H2A clustered histone 25 decreases expression ISO Berberine results in decreased expression of H2AC25 mRNA CTD PMID:27311644 NCBI chr11:58,845,511...58,846,018
Ensembl chr11:58,845,511...58,847,656
JBrowse link
G H2ac4 H2A clustered histone 4 decreases expression ISO Berberine results in decreased expression of H2AC4 mRNA CTD PMID:27311644 NCBI chr13:23,935,061...23,935,577
Ensembl chr13:23,935,109...23,935,581
JBrowse link
G H2ac6 H2A clustered histone 6 decreases expression ISO Berberine results in decreased expression of H2AC15 mRNA CTD PMID:27311644 NCBI chr13:23,867,456...23,867,942
Ensembl chr13:23,865,450...23,867,931
JBrowse link
G H2ax H2A.X variant histone increases expression
decreases expression
multiple interactions
ISO Berberine results in increased expression of H2AX protein modified form
Berberine results in decreased expression of H2AX mRNA; Berberine results in decreased expression of H2AX protein
TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
CTD PMID:23363784 PMID:23747414 PMID:27311644 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
JBrowse link
G H2bc12 H2B clustered histone 12 decreases expression ISO Berberine results in decreased expression of H2BC12 mRNA CTD PMID:27311644 NCBI chr13:22,219,991...22,220,490
Ensembl chr13:22,220,040...22,220,515
JBrowse link
G H2bc14 H2B clustered histone 14 decreases expression ISO Berberine results in decreased expression of H2BC5 mRNA CTD PMID:27311644 NCBI chr13:21,906,214...21,906,696
Ensembl chr13:21,906,214...21,906,737
JBrowse link
G H2bc15 H2B clustered histone 15 decreases expression ISO Berberine results in decreased expression of H2BC15 mRNA CTD PMID:27311644 NCBI chr13:21,938,246...21,938,723
Ensembl chr13:21,938,293...21,938,673
JBrowse link
G H2bc21 H2B clustered histone 21 decreases expression ISO Berberine results in decreased expression of H2BC11 mRNA CTD PMID:27311644 NCBI chr 3:96,128,435...96,131,057
Ensembl chr 3:96,128,435...96,131,054
JBrowse link
G H2bc22 H2B clustered histone 22 decreases expression ISO Berberine results in decreased expression of H2BC17 mRNA CTD PMID:27311644 NCBI chr13:21,971,652...21,985,731
Ensembl chr13:21,971,631...21,973,383
JBrowse link
G H2bc4 H2B clustered histone 4 decreases expression ISO Berberine results in decreased expression of H2BC4 mRNA CTD PMID:27311644 NCBI chr13:23,868,182...23,876,805
Ensembl chr13:23,868,182...23,876,891
JBrowse link
G H2bc6 H2B clustered histone 6 decreases expression ISO Berberine results in decreased expression of H2BC6 mRNA CTD PMID:27311644 NCBI chr13:23,767,653...23,805,091
Ensembl chr13:23,767,653...23,805,107
JBrowse link
G H2bc7 H2B clustered histone 7 decreases expression ISO Berberine results in decreased expression of H2BC13 mRNA CTD PMID:27311644 NCBI chr13:23,757,934...23,758,381
Ensembl chr13:23,757,910...23,758,370
JBrowse link
G H2bc8 H2B clustered histone 8 decreases expression ISO Berberine results in decreased expression of H2BC8 mRNA CTD PMID:27311644 NCBI chr13:23,755,574...23,756,037
Ensembl chr13:23,755,570...23,756,187
JBrowse link
G H2bc9 H2B clustered histone 9 decreases expression ISO Berberine results in decreased expression of H2BC9 mRNA CTD PMID:27311644 NCBI chr13:23,727,093...23,727,614
Ensembl chr13:23,725,884...23,727,562
JBrowse link
G H2bw2 H2B.W histone 2 decreases expression ISO Berberine results in decreased expression of H2BW2 mRNA CTD PMID:27311644 NCBI chr  X:135,828,074...135,829,122
Ensembl chr  X:135,828,074...135,829,125
JBrowse link
G H3c1 H3 clustered histone 1 decreases expression ISO Berberine results in decreased expression of H3C1 mRNA CTD PMID:27311644 NCBI chr13:23,945,868...23,946,369
Ensembl chr13:23,945,836...23,946,369
JBrowse link
G H3c11 H3 clustered histone 11 decreases expression ISO Berberine results in decreased expression of H3C7 mRNA CTD PMID:27311644 NCBI chr13:21,967,085...21,967,567
Ensembl chr13:21,967,130...21,967,540
JBrowse link
G H3c8 H3 clustered histone 8 decreases expression ISO Berberine results in decreased expression of H3C12 mRNA CTD PMID:27311644 NCBI chr13:23,719,588...23,720,079
Ensembl chr13:23,719,592...23,720,121
JBrowse link
G H3f3a H3.3 histone A decreases expression ISO Berberine results in decreased expression of H3-3A mRNA CTD PMID:27311644 NCBI chr 1:180,630,125...180,641,127
Ensembl chr 1:180,628,397...180,641,508
JBrowse link
G H3f4 H3.4 histone, cluster member decreases expression ISO Berberine results in decreased expression of H3-4 mRNA CTD PMID:27311644 NCBI chr11:58,852,537...58,853,099
Ensembl chr11:58,852,599...58,853,364
JBrowse link
G H4c12 H4 clustered histone 12 decreases expression ISO Berberine results in decreased expression of H4C8 mRNA CTD PMID:27311644 NCBI chr13:21,934,315...21,934,723
Ensembl chr13:21,934,364...21,934,675
JBrowse link
G H4c14 H4 clustered histone 14 decreases expression ISO Berberine results in decreased expression of H4C3 mRNA CTD PMID:27311644 NCBI chr 3:96,170,250...96,170,633
Ensembl chr 3:96,168,998...96,170,627
JBrowse link
G H4c2 H4 clustered histone 2 decreases expression ISO Berberine results in decreased expression of H4C14 mRNA CTD PMID:27311644 NCBI chr13:23,940,920...23,941,369
Ensembl chr13:23,940,996...23,941,392
JBrowse link
G H4c8 H4 clustered histone 8 decreases expression ISO Berberine results in decreased expression of H4C9 mRNA CTD PMID:27311644 NCBI chr13:23,715,214...23,715,648
Ensembl chr13:23,715,220...23,715,689
JBrowse link
G Hat1 histone aminotransferase 1 increases expression ISO Berberine results in increased expression of HAT1 mRNA CTD PMID:27311644 NCBI chr 2:71,219,604...71,271,966
Ensembl chr 2:71,219,302...71,271,966
JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO Berberine results in decreased expression of HDAC2 mRNA CTD PMID:27311644 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885
JBrowse link
G Hdac5 histone deacetylase 5 increases expression ISO Berberine results in increased expression of HDAC5 mRNA CTD PMID:27311644 NCBI chr11:102,085,244...102,120,968
Ensembl chr11:102,085,258...102,120,992
JBrowse link
G Hdac8 histone deacetylase 8 decreases expression ISO Berberine results in decreased expression of HDAC8 mRNA CTD PMID:27311644 NCBI chr  X:101,328,244...101,549,005
Ensembl chr  X:101,328,245...101,548,965
JBrowse link
G Hdac9 histone deacetylase 9 decreases expression
increases expression
ISO Berberine results in decreased expression of HDAC9 mRNA
Berberine results in increased expression of HDAC9 mRNA
CTD PMID:27311644 NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094
JBrowse link
G Hgf hepatocyte growth factor multiple interactions
increases expression
ISO
EXP
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF mRNA]; 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Berberine results in increased expression of HGF protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF protein]; Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein]; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
Berberine inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]
Berberine results in increased expression of HGF mRNA; Berberine results in increased expression of HGF protein
CTD PMID:29408570 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of HMGB1 protein] CTD PMID:38705399 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Berberine results in increased expression of HMOX1 protein
Berberine results in increased expression of HMOX1 mRNA; Berberine results in increased expression of HMOX1 protein
Berberine inhibits the reaction [Particulate Matter results in decreased expression of HMOX1 protein]
Berberine inhibits the reaction [Bortezomib results in increased expression of HMOX1 mRNA]
Berberine promotes the reaction [Glucose results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]
CTD PMID:23954465 PMID:35121005 PMID:37511356 PMID:37839514 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha multiple interactions ISO
EXP
Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]
Berberine inhibits the reaction [Ethanol results in decreased expression of HNF4 protein]
CTD PMID:18563319 PMID:25455889 NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830
JBrowse link
G Idh3a isocitrate dehydrogenase 3 (NAD+) alpha decreases expression ISO Berberine results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 9:54,493,795...54,511,946
Ensembl chr 9:54,493,618...54,511,945
JBrowse link
G Ifng interferon gamma multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in increased expression of IFNG mRNA] CTD PMID:30138605 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Igf1r insulin-like growth factor I receptor multiple interactions
increases expression
ISO Berberine inhibits the reaction [Glucose results in decreased expression of IGF1R protein]
Berberine results in increased expression of IGF1R protein
CTD PMID:23954465 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416
JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 decreases expression
multiple interactions
ISO
EXP
Berberine results in decreased expression of IGF2BP3 protein
Berberine inhibits the reaction [[Dextran Sulfate co-treated with azomethane] results in increased expression of IGF2BP3 protein]
[Chloroquine co-treated with Berberine] results in decreased expression of IGF2BP3 protein; Berberine promotes the reaction [IGF2BP3 protein binds to TRIM21 protein]; Cycloheximide promotes the reaction [Berberine results in decreased expression of IGF2BP3 protein]
CTD PMID:36822301 NCBI chr 6:49,062,152...49,200,225
Ensembl chr 6:49,062,157...49,191,891
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
EXP
ISO
Berberine affects the reaction [Lipopolysaccharides affects the expression of IL10 mRNA]
[Berberine co-treated with Thioacetamide] results in increased expression of IL10 mRNA; Berberine inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]
Berberine results in increased expression of IL10 mRNA
CTD PMID:21867779 PMID:30138605 PMID:37955270 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Bortezomib results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL1B mRNA]
CTD PMID:16391493 PMID:29170048 PMID:30138605 PMID:35121005 PMID:35691465 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il2 interleukin 2 increases expression EXP Berberine results in increased expression of IL2 mRNA CTD PMID:21867779 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il23a interleukin 23, alpha subunit p19 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein] CTD PMID:30240693 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
EXP Berberine inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 mRNA]
Berberine results in increased expression of IL4 mRNA
CTD PMID:21867779 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; Berberine inhibits the reaction [Bortezomib results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]; Berberine inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]
CTD PMID:28916288 PMID:29170048 PMID:30138605 PMID:30240693 PMID:34427876 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins2 insulin II multiple interactions ISO [Berberine co-treated with Streptozocin] results in increased secretion of INS protein CTD PMID:15066220 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Itga1 integrin alpha 1 increases expression ISO Berberine results in increased expression of ITGA1 mRNA CTD PMID:26478571 NCBI chr13:115,094,615...115,238,500
Ensembl chr13:115,089,632...115,238,500
JBrowse link
G Itgb4 integrin beta 4 increases expression ISO berberine increases expression of ITGB4 protein in colon epithelial cells RGD PMID:29564000 RGD:152995489 NCBI chr11:115,865,556...115,899,238
Ensembl chr11:115,865,535...115,899,238
JBrowse link
G Jun jun proto-oncogene affects localization
multiple interactions
ISO Berberine affects the localization of JUN protein
arsenic trioxide promotes the reaction [Berberine affects the localization of JUN protein]
CTD PMID:18294404 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity
multiple interactions
ISO Berberine results in decreased activity of KCNH2 protein
Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein]
CTD PMID:30086269 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Kdm1a lysine (K)-specific demethylase 1A increases expression ISO Berberine results in increased expression of KDM1A mRNA CTD PMID:27311644 NCBI chr 4:136,277,844...136,330,127
Ensembl chr 4:136,277,851...136,330,034
JBrowse link
G Kdm4a lysine (K)-specific demethylase 4A increases expression ISO Berberine results in increased expression of KDM4A mRNA CTD PMID:27311644 NCBI chr 4:117,994,154...118,037,216
Ensembl chr 4:117,994,154...118,037,240
JBrowse link
G Kdm5b lysine demethylase 5B increases expression ISO Berberine results in increased expression of KDM5B mRNA CTD PMID:27311644 NCBI chr 1:134,487,916...134,560,621
Ensembl chr 1:134,487,909...134,563,023
JBrowse link
G Kdm6a lysine (K)-specific demethylase 6A increases expression ISO Berberine results in increased expression of KDM6A mRNA CTD PMID:27311644 NCBI chr  X:18,027,101...18,147,061
Ensembl chr  X:18,028,814...18,146,175
JBrowse link
G Kdm6b KDM1 lysine (K)-specific demethylase 6B increases expression ISO Berberine results in increased expression of KDM6B mRNA CTD PMID:27311644 NCBI chr11:69,289,334...69,311,188
Ensembl chr11:69,289,334...69,304,501
JBrowse link
G Kmt5a lysine methyltransferase 5A increases expression ISO Berberine results in increased expression of KMT5A mRNA CTD PMID:27311644 NCBI chr 5:124,577,980...124,600,371
Ensembl chr 5:124,577,993...124,600,371
JBrowse link
G Kpna4 karyopherin subunit alpha 4 multiple interactions ISO Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of NFKBIA protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of RELA protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]] CTD PMID:34427876 NCBI chr 3:68,979,554...69,034,425
Ensembl chr 3:68,974,482...69,034,446
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression
EXP
ISO
Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]
Berberine results in increased expression of LDLR mRNA
Berberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]; Simvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]
CTD PMID:18640378 PMID:20564506 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases localization
ISO [Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein; Berberine results in increased expression of and results in increased lipidation of MAP1LC3B protein; BNIP3L protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]; FUNDC1 protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]
Berberine inhibits the reaction [Chlorpyrifos results in decreased expression of MAP1LC3B mRNA]
Berberine results in increased localization of MAP1LC3B protein
CTD PMID:35439518 PMID:36070022 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein] CTD PMID:30240693 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO Berberine results in decreased phosphorylation of MAPK1 protein CTD PMID:18294404 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO
EXP
Berberine results in decreased phosphorylation of MAPK3 protein
Berberine inhibits the reaction [Dexamethasone results in decreased expression of MAPK3 mRNA]
CTD PMID:18294404 PMID:20462044 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Berberine co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein] CTD PMID:36070022 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] CTD PMID:29170048 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions EXP Berberine inhibits the reaction [Dexamethasone results in increased expression of MCM2 mRNA] CTD PMID:20462044 NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762
JBrowse link
G Mir142 microRNA 142 multiple interactions ISO Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of MIR142 mRNA]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]] CTD PMID:34427876 NCBI chr11:87,647,690...87,647,753
Ensembl chr11:87,647,690...87,647,753
JBrowse link
G Mir19a microRNA 19a decreases expression ISO Berberine results in decreased expression of MIR19A mRNA CTD PMID:29687521 NCBI chr14:115,281,432...115,281,513
Ensembl chr14:115,281,432...115,281,513
JBrowse link
G Mir21a microRNA 21a decreases expression ISO berberine decreases expression of MIR21 RNA in colon epithelial cell RGD PMID:29564000 RGD:152995489 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984
JBrowse link
G Mir92-1 microRNA 92-1 decreases expression ISO Berberine results in decreased expression of MIR92A1 mRNA CTD PMID:29687521 NCBI chr14:115,281,859...115,281,938
Ensembl chr14:115,281,859...115,281,938
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Berberine results in increased expression of MMP13 mRNA CTD PMID:26478571 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP14 protein] CTD PMID:18294404 NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; Arsenic Trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; Berberine promotes the reaction [Arsenic Trioxide results in decreased activity of MMP2 protein]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]
Berberine results in decreased expression of MMP2 protein
arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]
CTD PMID:18294404 PMID:33325633 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
multiple interactions
ISO Berberine results in decreased activity of MMP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]
CTD PMID:33325633 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:21963898 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial multiple interactions ISO Berberine inhibits the reaction [acetamiprid results in decreased expression of COX1 mRNA] CTD PMID:37350525 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
JBrowse link
G mt-Nd1 NADH dehydrogenase 1, mitochondrial multiple interactions ISO Berberine inhibits the reaction [acetamiprid results in decreased expression of ND1 mRNA] CTD PMID:37350525 NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707
JBrowse link
G mt-Nd2 NADH dehydrogenase 2, mitochondrial multiple interactions ISO Berberine inhibits the reaction [acetamiprid results in decreased expression of ND2 mRNA] CTD PMID:37350525 NCBI chr MT:3,914...4,951
Ensembl chr MT:3,914...4,951
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO Berberine inhibits the reaction [Chlorpyrifos results in increased expression of MTOR mRNA]; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of MTOR protein] CTD PMID:35439518 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of MTTP protein] CTD PMID:25455889 NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions
affects localization
ISO arsenic trioxide promotes the reaction [Berberine affects the localization of MYC protein] CTD PMID:18294404 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions
decreases expression
ISO [Berberine co-treated with Niacinamide] results in decreased expression of NAMPT protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of NAMPT protein] CTD PMID:26712469 NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to NCF1 protein] CTD PMID:36070022 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to NCF2 protein] CTD PMID:36070022 NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions
increases activity
ISO
EXP
Berberine results in increased expression of NFE2L2 protein
Berberine inhibits the reaction [Particulate Matter results in decreased expression of NFE2L2 protein]
Berberine results in increased activity of NFE2L2 protein
Berberine inhibits the reaction [Bortezomib results in increased expression of NFE2L2 mRNA]; Berberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein]
NFE2L2 mutant form inhibits the reaction [Berberine inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein]
CTD PMID:23523906 PMID:23954465 PMID:30818834 PMID:35121005 PMID:37839514 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of NFKB1 mRNA] CTD PMID:35121005 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP
ISO
Berberine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of NFKBIA protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of NFKBIA protein]]
CTD PMID:21963898 PMID:34427876 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Ngf nerve growth factor multiple interactions ISO Berberine inhibits the reaction [Glucose results in decreased expression of NGF protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein] CTD PMID:23954465 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP
Berberine inhibits the reaction [Bortezomib results in increased expression of NLRP3 mRNA]
Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 mRNA]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 protein]
CTD PMID:35121005 PMID:38705399 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
Berberine inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]
CTD PMID:21095217 PMID:23523906 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO Berberine reverses reaction [Carbontetrachloride decreases Nqo1 mRNA in liver]
Berberine inhibits the reaction [Bortezomib results in increased expression of NQO1 mRNA]
CTD
RGD
PMID:35121005 PMID:31432116 RGD:25823187 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases localization ISO Berberine increases localization of NR1H3 protein in macrophage nucleus RGD PMID:20506155 RGD:401827279 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Berberine results in increased activity of NR1I2 protein
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:21524698 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Berberine results in increased activity of NR1I3 protein CTD PMID:30818834 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 decreases expression ISO Berberine results in decreased expression of NSD2 mRNA CTD PMID:27311644 NCBI chr 5:33,974,286...34,055,310
Ensembl chr 5:33,978,069...34,055,319
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of ODC1 protein] CTD PMID:18294404 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506
JBrowse link
G Omd osteomodulin increases expression ISO Berberine results in increased expression of OMD mRNA CTD PMID:26478571 NCBI chr13:49,735,938...49,746,088
Ensembl chr13:49,735,938...49,746,298
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 multiple interactions ISO Berberine affects the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] CTD PMID:21320518 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions
ISO Berberine results in increased cleavage of PARP1 protein
[Berberine co-treated with Cisplatin] results in increased cleavage of PARP1 protein; [Berberine co-treated with Niacinamide] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of PARP1 protein]
CTD PMID:16505103 PMID:26712469 PMID:36070022 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Berberine increases expression of PDCD4 protein in colon epithelial cells RGD PMID:29564000 RGD:152995489 NCBI chr19:53,880,662...53,926,024
Ensembl chr19:53,880,662...53,918,291
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 increases expression EXP Berberine results in increased expression of PDK4 mRNA CTD PMID:37511356 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP
ISO
Berberine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]
Berberine inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of PPARA protein]
CTD PMID:18338635 PMID:25455889 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Ppard peroxisome proliferator activator receptor delta increases activity
multiple interactions
increases expression
EXP
ISO
Berberine results in increased activity of PPARD protein
Berberine inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of PPARD protein]
Berberine results in increased expression of PPARD mRNA; Berberine results in increased expression of PPARD protein
CTD PMID:18338635 PMID:37511356 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
decreases expression
increases response to substance
increases expression
EXP
ISO
Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]
Berberine inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in decreased expression of PPARG protein]
Berberine results in decreased expression of PPARG mRNA; Berberine results in decreased expression of PPARG protein
15-deoxyprostaglandin J2 promotes the reaction [Berberine affects the localization of and results in increased activity of PPARG protein]; Berberine inhibits the reaction [Bleomycin binds to PPARG protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 affects the localization of and results in increased activity of PPARG protein]; Berberine results in increased activity of and affects the localization of PPARG protein; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
PPARG mRNA results in increased susceptibility to Berberine
Berberine results in increased expression of PPARG mRNA
CTD PMID:18338635 PMID:20564506 PMID:26478571 PMID:29408570 PMID:37511356 More... NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA] CTD PMID:25455889 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Prg4 proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) decreases expression ISO Berberine results in decreased expression of PRG4 mRNA CTD PMID:26478571 NCBI chr 1:150,325,163...150,341,916
Ensembl chr 1:150,325,163...150,341,916
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases phosphorylation EXP Berberine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCA protein]; Berberine results in decreased activity of and affects the localization of PRKCA protein CTD PMID:18294404 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions
decreases activity
ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCE protein]; Berberine results in decreased activity of and affects the localization of PRKCE protein CTD PMID:18294404 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347
JBrowse link
G Prmt1 protein arginine N-methyltransferase 1 decreases expression ISO Berberine results in decreased expression of PRMT1 mRNA CTD PMID:27311644 NCBI chr 7:44,626,179...44,635,844
Ensembl chr 7:44,625,413...44,635,992
JBrowse link
G Prmt2 protein arginine N-methyltransferase 2 increases expression ISO Berberine results in increased expression of PRMT2 mRNA CTD PMID:27311644 NCBI chr10:76,043,060...76,073,699
Ensembl chr10:76,043,056...76,073,699
JBrowse link
G Prmt5 protein arginine N-methyltransferase 5 increases expression ISO Berberine results in increased expression of PRMT5 mRNA CTD PMID:27311644 NCBI chr14:54,744,639...54,754,927
Ensembl chr14:54,744,644...54,754,982
JBrowse link
G Prmt6 protein arginine N-methyltransferase 6 increases expression ISO Berberine results in increased expression of PRMT6 mRNA CTD PMID:27311644 NCBI chr 3:110,153,420...110,158,315
Ensembl chr 3:110,153,425...110,158,314
JBrowse link
G Prmt7 protein arginine N-methyltransferase 7 increases expression ISO Berberine results in increased expression of PRMT7 mRNA CTD PMID:27311644 NCBI chr 8:106,937,686...106,978,326
Ensembl chr 8:106,937,568...106,979,426
JBrowse link
G Prmt8 protein arginine N-methyltransferase 8 increases expression ISO Berberine results in increased expression of PRMT8 mRNA CTD PMID:27311644 NCBI chr 6:127,665,972...127,746,430
Ensembl chr 6:127,665,974...127,746,435
JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions
EXP Berberine results in increased expression of PTEN protein
((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN protein]
CTD PMID:29408570 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] CTD PMID:21095217 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of PYCARD mRNA] CTD PMID:38705399 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039
JBrowse link
G Rac2 Rac family small GTPase 2 multiple interactions ISO Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to RAC2 protein]; Berberine results in increased expression of and results in increased activity of RAC2 protein CTD PMID:36070022 NCBI chr15:78,443,369...78,456,983
Ensembl chr15:78,443,367...78,456,983
JBrowse link
G Rbp4 retinol binding protein 4, plasma multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Berberine inhibits the reaction [Bleomycin affects the localization of and results in increased expression of RELA protein]
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of RELA protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of RELA protein]]
CTD PMID:23523906 PMID:34427876 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rln1 relaxin 1 affects binding
increases expression
multiple interactions
ISO Berberine binds to RLN1 promoter
Berberine results in increased expression of RLN1 mRNA
[Berberine binds to RLN1 promoter] which results in increased expression of RLN1 mRNA
CTD PMID:22363579 NCBI chr19:29,309,155...29,312,070
Ensembl chr19:29,308,570...29,312,070
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO Berberine results in decreased phosphorylation of RPS6 protein CTD PMID:23363784 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649
JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions
increases expression
ISO CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA] CTD PMID:26478571 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684
JBrowse link
G Setd1b SET domain containing 1B increases expression ISO Berberine results in increased expression of SETD1B mRNA CTD PMID:27311644 NCBI chr 5:123,280,109...123,306,693
Ensembl chr 5:123,280,256...123,306,692
JBrowse link
G Setd2 SET domain containing 2 increases expression ISO Berberine results in increased expression of SETD2 mRNA CTD PMID:27311644 NCBI chr 9:110,361,368...110,447,703
Ensembl chr 9:110,358,262...110,447,701
JBrowse link
G Setd3 SET domain containing 3 increases expression ISO Berberine results in increased expression of SETD3 mRNA CTD PMID:27311644 NCBI chr12:108,072,690...108,145,616
Ensembl chr12:108,072,690...108,145,573
JBrowse link
G Setd5 SET domain containing 5 increases expression ISO Berberine results in increased expression of SETD5 mRNA CTD PMID:27311644 NCBI chr 6:113,054,326...113,130,393
Ensembl chr 6:113,054,326...113,130,396
JBrowse link
G Setd6 SET domain containing 6 increases expression ISO Berberine results in increased expression of SETD6 mRNA CTD PMID:27311644 NCBI chr 8:96,442,211...96,448,135
Ensembl chr 8:96,442,509...96,445,638
JBrowse link
G Setd7 SET domain containing (lysine methyltransferase) 7 increases expression ISO Berberine results in increased expression of SETD7 mRNA CTD PMID:27311644 NCBI chr 3:51,422,740...51,468,519
Ensembl chr 3:51,422,740...51,468,300
JBrowse link
G Setdb1 SET domain, bifurcated 1 increases expression ISO Berberine results in increased expression of SETDB1 mRNA CTD PMID:27311644 NCBI chr 3:95,230,836...95,264,513
Ensembl chr 3:95,230,836...95,264,513
JBrowse link
G Setdb2 SET domain, bifurcated 2 increases expression ISO Berberine results in increased expression of SETDB2 mRNA CTD PMID:27311644 NCBI chr14:59,639,458...59,678,329
Ensembl chr14:59,639,458...59,678,333
JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions
ISO Berberine results in decreased expression of SIRT1 mRNA; Berberine results in decreased expression of SIRT1 protein
Berberine inhibits the reaction [Bortezomib results in decreased expression of SIRT1 protein]
[Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein]
CTD PMID:26712469 PMID:35121005 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein CTD PMID:26712469 NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086
JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
decreases expression
ISO [Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein
Berberine results in increased expression of SIRT3 mRNA
Berberine results in decreased expression of SIRT3 mRNA; Berberine results in decreased expression of SIRT3 protein
CTD PMID:26712469 PMID:27311644 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222
JBrowse link
G Sis sucrase isomaltase decreases expression
multiple interactions
ISO Berberine results in decreased expression of SI mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA]
CTD PMID:20229011 NCBI chr 3:72,795,890...72,875,196
Ensembl chr 3:72,795,890...72,875,196
JBrowse link
G Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 decreases expression ISO Berberine results in decreased expression of SLC27A5 mRNA CTD PMID:28038998 NCBI chr 7:12,722,273...12,732,119
Ensembl chr 7:12,722,273...12,732,119
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein] CTD PMID:19080170 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
JBrowse link
G Slc6a19 solute carrier family 6 (neurotransmitter transporter), member 19 multiple interactions ISO Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 mRNA]; Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 protein] CTD PMID:21073932 NCBI chr13:73,827,864...73,848,899
Ensembl chr13:73,827,864...73,852,984
JBrowse link
G Smyd3 SET and MYND domain containing 3 affects expression ISO Berberine affects the expression of SMYD3 mRNA CTD PMID:27311644 NCBI chr 1:178,779,525...179,345,618
Ensembl chr 1:178,779,525...179,345,606
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP Berberine inhibits the reaction [Particulate Matter results in decreased expression of SOCS3 mRNA]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of SOCS3 protein] CTD PMID:37839514 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP
ISO
Berberine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of SOD1 protein]; Berberine inhibits the reaction [Streptozocin affects the expression of SOD1 mRNA]
Berberine inhibits the reaction [Chlorpyrifos results in decreased activity of SOD1 protein]
CTD PMID:21095217 PMID:22775417 PMID:35439518 PMID:37839514 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP
ISO
Berberine inhibits the reaction [Streptozocin affects the expression of SOD2 mRNA]
Berberine inhibits the reaction [acetamiprid results in decreased expression of SOD2 mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of SOD2 mRNA]
CTD PMID:22775417 PMID:24751971 PMID:33460233 PMID:37350525 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 decreases expression ISO Berberine results in decreased expression of SOX9 mRNA CTD PMID:26478571 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586
JBrowse link
G Sp7 Sp7 transcription factor 7 increases expression ISO Berberine results in increased expression of SP7 mRNA CTD PMID:26478571 NCBI chr15:102,265,038...102,275,498
Ensembl chr15:102,265,041...102,275,617
JBrowse link
G Sparc secreted acidic cysteine rich glycoprotein increases expression ISO Berberine results in increased expression of SPARC mRNA CTD PMID:26478571 NCBI chr11:55,284,985...55,310,906
Ensembl chr11:55,285,326...55,314,009
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression
multiple interactions
ISO Berberine results in increased expression of SPP1 mRNA; Berberine results in increased expression of SPP1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein]
CTD PMID:26478571 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
ISO
EXP
Berberine results in increased expression of SQSTM1 protein
[Berberine co-treated with Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of SQSTM1 protein
CTD PMID:36070022 PMID:38705399 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
EXP
ISO
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Berberine results in decreased expression of SREBF1 mRNA
CTD PMID:20564506 PMID:26478571 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP
Berberine inhibits the reaction [Bortezomib results in increased expression of STAT3 mRNA]
Berberine inhibits the reaction [Particulate Matter results in increased expression of STAT3 mRNA]
CTD PMID:35121005 PMID:37839514 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO Berberine results in decreased activity of TERT protein CTD PMID:25265580 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
ISO
EXP
Berberine results in decreased expression of TGFB1 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of TGFB1 mRNA]
Berberine inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
CTD PMID:17973934 PMID:23523906 PMID:30138605 PMID:37839514 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP
ISO
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]
Berberine inhibits the reaction [Bortezomib results in increased expression of TLR4 protein]
CTD PMID:21963898 PMID:30240693 PMID:35121005 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression
ISO
EXP
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; Berberine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Berberine inhibits the reaction [Bortezomib results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]
Berberine results in increased secretion of TNF protein
Berberine results in increased expression of TNF mRNA
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Berberine inhibits the reaction [Dietary Fats results in increased secretion of TNF protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Particulate Matter results in increased expression of TNF protein]
CTD PMID:16391493 PMID:20656010 PMID:21095217 PMID:21867779 PMID:23523906 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Top1 topoisomerase (DNA) I decreases activity ISO Berberine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr 2:160,487,901...160,564,684
Ensembl chr 2:160,487,808...160,564,684
JBrowse link
G Top2a topoisomerase (DNA) II alpha multiple interactions
affects response to substance
ISO TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
TOP2A protein affects the susceptibility to Berberine
CTD PMID:23747414 NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015
JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO Berberine results in increased expression of TRAF1 protein CTD PMID:20656010 NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784
JBrowse link
G Traf2 TNF receptor-associated factor 2 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein] CTD PMID:30240693 NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952
JBrowse link
G Trim21 tripartite motif-containing 21 multiple interactions ISO Berberine promotes the reaction [IGF2BP3 protein binds to TRIM21 protein] CTD PMID:36822301 NCBI chr 7:102,207,127...102,214,689
Ensembl chr 7:102,207,128...102,214,693
JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions
ISO Berberine results in increased expression of TP53 mRNA; Berberine results in increased expression of TP53 protein
[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of TP53 protein; Berberine results in increased phosphorylation of and results in increased acetylation of TP53 protein
CTD PMID:20656010 PMID:26712469 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Tstd1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 increases expression ISO Berberine results in increased expression of TSTD1 mRNA CTD PMID:27311644 NCBI chr 1:171,246,601...171,247,920
Ensembl chr 1:171,246,440...171,247,920
JBrowse link
G Ube2a ubiquitin-conjugating enzyme E2A decreases expression ISO Berberine results in decreased expression of UBE2A mRNA CTD PMID:27311644 NCBI chr  X:36,137,948...36,147,875
Ensembl chr  X:36,064,828...36,147,875
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B decreases expression ISO Berberine results in decreased expression of UBE2B mRNA CTD PMID:27311644 NCBI chr11:51,875,965...51,894,972
Ensembl chr11:51,876,324...51,891,589
JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions
increases expression
EXP Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]
Berberine results in increased expression of UCP2 mRNA
CTD PMID:28533128 PMID:37511356 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Berberine results in decreased expression of VEGFA protein CTD PMID:33325633 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vegfc vascular endothelial growth factor C increases expression ISO Berberine results in increased expression of VEGFC mRNA CTD PMID:26478571 NCBI chr 8:54,530,567...54,639,489
Ensembl chr 8:54,530,641...54,640,131
JBrowse link
entacapone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox3 acyl-Coenzyme A oxidase 3, pristanoyl affects binding ISO entacapone binds to ACOX3 protein CTD PMID:19783845 NCBI chr 5:35,740,293...35,772,397
Ensembl chr 5:35,740,384...35,772,696
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 affects binding ISO entacapone binds to ACSL1 protein CTD PMID:19783845 NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088
JBrowse link
G Adprhl1 ADP-ribosylhydrolase like 1 affects binding ISO entacapone binds to ADPRHL1 protein CTD PMID:19783845 NCBI chr 8:13,268,449...13,304,079
Ensembl chr 8:13,271,663...13,304,162
JBrowse link
G Auh AU RNA binding protein/enoyl-coenzyme A hydratase affects binding ISO entacapone binds to AUH protein CTD PMID:19783845 NCBI chr13:52,989,155...53,083,742
Ensembl chr13:52,989,155...53,083,717
JBrowse link
G Cltc clathrin heavy chain affects binding ISO entacapone binds to CLTC protein CTD PMID:19783845 NCBI chr11:86,585,178...86,648,637
Ensembl chr11:86,585,177...86,648,391
JBrowse link
G Comt catechol-O-methyltransferase decreases activity
affects binding
multiple interactions
ISO
EXP
entacapone results in decreased activity of COMT protein
entacapone binds to COMT protein
[entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; entacapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]
CTD PMID:12898346 PMID:15566291 PMID:19783845 PMID:20334432 PMID:23206800 More... NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO entacapone results in increased expression of CXCL8 mRNA CTD PMID:32816093 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial affects binding ISO entacapone binds to ECHS1 protein CTD PMID:19783845 NCBI chr 7:139,685,623...139,696,334
Ensembl chr 7:139,685,623...139,696,389
JBrowse link
G Ereg epiregulin increases expression ISO entacapone results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression ISO entacapone results in decreased expression of GPAM protein CTD PMID:29688484 NCBI chr19:55,056,067...55,115,666
Ensembl chr19:55,055,700...55,115,670
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain affects binding ISO entacapone binds to HBB protein CTD PMID:19783845
G Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 affects binding ISO entacapone binds to HSD17B13 protein CTD PMID:19783845 NCBI chr 5:104,103,308...104,125,254
Ensembl chr 5:104,103,306...104,125,276
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects binding ISO entacapone binds to HSD17B4 protein CTD PMID:19783845 NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO entacapone results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta increases expression ISO entacapone results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Met met proto-oncogene increases expression ISO entacapone results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
JBrowse link
G Pcx pyruvate carboxylase affects binding ISO entacapone binds to PC protein CTD PMID:19783845 NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 decreases expression ISO entacapone results in decreased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 1:84,014,014...84,317,550
Ensembl chr 1:84,014,017...84,341,901
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO entacapone results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 decreases expression ISO entacapone results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO entacapone results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
JBrowse link
G Snca synuclein, alpha multiple interactions ISO entacapone inhibits the reaction [SNCA protein binds to SNCA protein] CTD PMID:20150427 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 affects binding ISO entacapone binds to SULT2A1 protein CTD PMID:19783845 NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334
JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 decreases expression ISO entacapone results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of entacapone CTD PMID:15802387 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of entacapone CTD PMID:15802387 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of entacapone CTD PMID:15802387 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases glucuronidation
decreases glucuronidation
ISO UGT1A9 protein results in increased glucuronidation of entacapone
UGT1A9 protein mutant form results in decreased glucuronidation of entacapone
CTD PMID:15044611 PMID:15802387 PMID:16344532 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719
JBrowse link
GSK343 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1, ribonuclease type III increases expression ISO GSK343 results in increased expression of DICER1 mRNA CTD PMID:25351418 NCBI chr12:104,654,001...104,718,331
Ensembl chr12:104,654,001...104,718,211
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases activity ISO GSK343 results in decreased activity of EZH2 protein CTD PMID:23759589 PMID:24900432 NCBI chr 6:47,507,208...47,613,843
Ensembl chr 6:47,507,073...47,572,275
JBrowse link
LLY-507 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule multiple interactions EXP [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of CD36 mRNA CTD PMID:29718165 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Ifng interferon gamma multiple interactions EXP [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of CD36 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MARCO mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MMP9 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MSR1 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of IL6 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of TNF mRNA CTD PMID:29718165 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of IL6 mRNA CTD PMID:29718165 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Marco macrophage receptor with collagenous structure multiple interactions EXP [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MARCO mRNA CTD PMID:29718165 NCBI chr 1:120,402,267...120,432,753
Ensembl chr 1:120,402,267...120,432,753
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MMP9 mRNA CTD PMID:29718165 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions EXP [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MSR1 mRNA CTD PMID:29718165 NCBI chr 8:39,996,284...40,095,790
Ensembl chr 8:40,034,726...40,095,714
JBrowse link
G Smyd2 SET and MYND domain containing 2 multiple interactions ISO LLY-507 binds to and results in decreased activity of SMYD2 protein CTD PMID:25825497 NCBI chr 1:189,612,689...189,654,758
Ensembl chr 1:189,612,689...189,654,560
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of TNF mRNA CTD PMID:29718165 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
N-ethylmaleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases activity ISO Ethylmaleimide results in decreased activity of ABCB1 protein CTD PMID:2900677 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 affects activity
multiple interactions
ISO Ethylmaleimide affects the activity of ABCC1 protein
Ethylmaleimide inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
CTD PMID:9096673 PMID:9334814 PMID:16101123 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases activity ISO Ethylmaleimide results in decreased activity of ACSL4 protein CTD PMID:11319222 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531
JBrowse link
G Alb albumin decreases transport ISO Ethylmaleimide results in decreased transport of ALB protein CTD PMID:15897811 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596
JBrowse link
G Atp7a ATPase, copper transporting, alpha polypeptide multiple interactions
increases glutathionylation
ISO Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:105,070,830...105,171,766
Ensembl chr  X:105,070,882...105,168,532
JBrowse link
G Atp8b1 ATPase, class I, type 8B, member 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines] CTD PMID:11584374 NCBI chr18:64,662,050...64,794,342
Ensembl chr18:64,662,038...64,794,338
JBrowse link
G Cbr2 carbonyl reductase 2 increases acylation EXP Ethylmaleimide results in increased acylation of CBR2 protein CTD PMID:18597497 NCBI chr11:120,620,311...120,622,851
Ensembl chr11:120,620,315...120,622,940
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767
JBrowse link
G Chat choline O-acetyltransferase decreases activity EXP Ethylmaleimide results in decreased activity of CHAT protein CTD PMID:3437937 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions EXP Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] CTD PMID:10820281 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
JBrowse link
G Dusp23 dual specificity phosphatase 23 multiple interactions ISO Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr 1:172,458,336...172,460,504
Ensembl chr 1:172,458,331...172,460,529
JBrowse link
G F3 coagulation factor III increases expression ISO Ethylmaleimide results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases activity ISO Ethylmaleimide results in decreased activity of GAD1 protein CTD PMID:15836621 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
JBrowse link
G Gad2 glutamic acid decarboxylase 2 decreases activity ISO Ethylmaleimide results in decreased activity of GAD2 protein CTD PMID:15836621 NCBI chr 2:22,512,262...22,583,889
Ensembl chr 2:22,512,217...22,583,886
JBrowse link
G Hoxb13 homeobox B13 increases response to substance ISO HOXB13 protein results in increased susceptibility to Ethylmaleimide CTD PMID:24213000 NCBI chr11:96,085,142...96,087,436
Ensembl chr11:96,085,142...96,088,273
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein] CTD PMID:22796344 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620
JBrowse link
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble multiple interactions
decreases activity
ISO isocitric acid inhibits the reaction [Ethylmaleimide results in decreased activity of IDH1 protein]; NADP promotes the reaction [Ethylmaleimide results in decreased activity of IDH1 protein] CTD PMID:8486157 NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Ltbr lymphotoxin B receptor multiple interactions ISO Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr 6:125,283,534...125,291,026
Ensembl chr 6:125,283,534...125,290,848
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mt3 metallothionein 3 increases alkylation ISO Ethylmaleimide results in increased alkylation of MT3 protein CTD PMID:12383939 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774
JBrowse link
G Osm oncostatin M multiple interactions ISO Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr11:4,186,831...4,191,027
Ensembl chr11:4,186,420...4,191,026
JBrowse link
G Pah phenylalanine hydroxylase multiple interactions EXP Ethylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] CTD PMID:19367645 NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998
JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein] CTD PMID:26060329 NCBI chr15:97,936,625...97,991,625
Ensembl chr15:97,936,625...97,991,625
JBrowse link
G Senp6 SUMO/sentrin specific peptidase 6 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr 9:79,973,862...80,052,064
Ensembl chr 9:79,974,185...80,052,235
JBrowse link
G Slc12a5 solute carrier family 12, member 5 increases activity
multiple interactions
ISO Ethylmaleimide results in increased activity of SLC12A5 protein
Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]
CTD PMID:20086212 NCBI chr 2:164,802,766...164,841,651
Ensembl chr 2:164,802,722...164,841,651
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 3:104,545,980...104,565,778
Ensembl chr 3:104,545,984...104,565,778
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions EXP
ISO
Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839
JBrowse link
G Sumo2 small ubiquitin-like modifier 2 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]; Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr11:115,413,935...115,427,056
Ensembl chr11:115,413,928...115,427,102
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trf transferrin decreases uptake EXP Ethylmaleimide results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
JBrowse link
G Vdac1 voltage-dependent anion channel 1 affects binding ISO Ethylmaleimide binds to VDAC1 protein CTD PMID:20192921 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
decreases activity
ISO Dithiothreitol promotes the reaction [Ethylmaleimide results in decreased activity of VKORC1 protein] CTD PMID:2319331 NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626
JBrowse link
pemetrexed term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP-binding cassette, sub-family C member 5 decreases response to substance ISO ABCC5 protein results in decreased susceptibility to Pemetrexed CTD PMID:15897250 NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144
JBrowse link
G Alk anaplastic lymphoma kinase affects response to substance ISO ALK gene mutant form affects the susceptibility to Pemetrexed CTD PMID:21336183 NCBI chr17:72,174,206...72,911,719
Ensembl chr17:72,175,967...72,911,622
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression
multiple interactions
ISO Pemetrexed results in increased expression of BBC3 protein
xanthohumol promotes the reaction [Pemetrexed results in increased expression of BBC3 protein]
CTD PMID:35259468 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [Cisplatin co-treated with Pemetrexed co-treated with Valproic Acid] results in decreased expression of BCL2 protein; [Cisplatin co-treated with Pemetrexed co-treated with vorinostat] results in decreased expression of BCL2 protein CTD PMID:19351772 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Cisplatin co-treated with Pemetrexed] results in increased cleavage of BID protein CTD PMID:19351772 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
JBrowse link
G C3 complement component 3 multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of C3 mRNA; [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of C3 protein CTD PMID:22975265 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of CCL2 mRNA CTD PMID:22975265 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Cisplatin co-treated with Pemetrexed co-treated with Valproic Acid] results in decreased expression of CCND1 protein; [Cisplatin co-treated with Pemetrexed co-treated with vorinostat] results in decreased expression of CCND1 protein CTD PMID:19351772 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO [Cisplatin co-treated with Pemetrexed co-treated with Valproic Acid] results in increased expression of CDKN1A protein; [Cisplatin co-treated with Pemetrexed co-treated with vorinostat] results in increased expression of CDKN1A protein; [Cisplatin co-treated with Pemetrexed] results in increased expression of CDKN1A protein CTD PMID:19351772 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases response to substance ISO CFLAR results in decreased susceptibility to Pemetrexed CTD PMID:21726997 NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of CXCL8 mRNA; [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of CXCL8 protein CTD PMID:22975265 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO DDIT3 mutant form inhibits the reaction [Pemetrexed results in increased expression of TNFRSF10B] CTD PMID:21726997 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Dhfr dihydrofolate reductase multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of DHFR mRNA CTD PMID:22975265 NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561
JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 multiple interactions
decreases expression
ISO Pemetrexed inhibits the reaction [resveratrol results in increased stability of and results in increased expression of ERCC1 mRNA]; Pemetrexed inhibits the reaction [resveratrol results in increased stability of and results in increased expression of ERCC1 protein]
Pemetrexed results in decreased expression of ERCC1 mRNA; Pemetrexed results in decreased expression of ERCC1 protein
CTD PMID:23912706 NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449
JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions
ISO Pemetrexed results in increased expression of FAS protein
TP53 protein affects the reaction [Pemetrexed results in increased expression of FAS protein]; TYMS protein inhibits the reaction [Pemetrexed results in increased expression of FAS protein]
CTD PMID:15161716 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fpgs folylpolyglutamyl synthetase increases response to substance ISO FPGS protein results in increased susceptibility to Pemetrexed CTD PMID:17575230 NCBI chr 2:32,572,621...32,594,163
Ensembl chr 2:32,572,621...32,594,157
JBrowse link
G Ggh gamma-glutamyl hydrolase affects response to substance ISO GGH protein affects the susceptibility to Pemetrexed CTD PMID:17575230 NCBI chr 4:20,041,963...20,066,111
Ensembl chr 4:20,042,052...20,066,750
JBrowse link
G Ifi30 interferon gamma inducible protein 30 multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IFI30 mRNA CTD PMID:22975265 NCBI chr 8:71,215,418...71,219,307
Ensembl chr 8:71,215,419...71,219,307
JBrowse link
G Il11 interleukin 11 multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL11 mRNA CTD PMID:22975265 NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858
JBrowse link
G Il13ra2 interleukin 13 receptor, alpha 2 multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL13RA2 mRNA CTD PMID:22975265 NCBI chr  X:146,166,474...146,214,982
Ensembl chr  X:146,166,472...146,212,188
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL1A mRNA CTD PMID:22975265 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL1RL1 mRNA CTD PMID:22975265 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575
JBrowse link
G Il33 interleukin 33 multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL33 mRNA CTD PMID:22975265 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
JBrowse link
G Il7r interleukin 7 receptor multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL7R mRNA CTD PMID:22975265 NCBI chr15:9,505,880...9,530,270
Ensembl chr15:9,505,874...9,530,262
JBrowse link
G Klrc1 killer cell lectin-like receptor subfamily C, member 1 multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of KLRC1 mRNA CTD PMID:22975265 NCBI chr 6:129,642,978...129,659,815
Ensembl chr 6:129,642,978...129,655,936
JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog decreases expression
increases response to substance
ISO Pemetrexed results in decreased expression of KRAS mRNA; Pemetrexed results in decreased expression of KRAS mRNA mutant form; Pemetrexed results in decreased expression of KRAS protein
KRAS gene mutant form results in increased susceptibility to Pemetrexed
CTD PMID:24688052 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase increases response to substance ISO MTHFD2 protein results in increased susceptibility to Pemetrexed CTD PMID:24688052 NCBI chr 6:83,282,686...83,302,926
Ensembl chr 6:83,282,673...83,302,890
JBrowse link
G Npm1 nucleophosmin 1 decreases response to substance ISO NPM1 protein results in decreased susceptibility to Pemetrexed CTD PMID:24736981 NCBI chr11:33,102,498...33,114,143
Ensembl chr11:33,102,287...33,113,206
JBrowse link
G Nras neuroblastoma ras oncogene increases response to substance ISO NRAS gene mutant form results in increased susceptibility to Pemetrexed CTD PMID:24688052 NCBI chr 3:102,965,643...102,975,230
Ensembl chr 3:102,965,601...102,975,230
JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to Pemetrexed CTD PMID:16061639 NCBI chr 2:11,590,250...11,608,061
Ensembl chr 2:11,590,248...11,608,964
JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 multiple interactions
increases response to substance
ISO Pemetrexed inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate]
SLC19A1 exon mutant form results in increased susceptibility to Pemetrexed
CTD PMID:16505119 PMID:21879757 NCBI chr10:76,868,103...76,886,266
Ensembl chr10:76,868,075...76,896,836
JBrowse link
G Slc46a1 solute carrier family 46, member 1 multiple interactions
increases activity
increases response to substance
ISO Pemetrexed inhibits the reaction [SLC46A1 protein results in increased uptake of Methotrexate]
Pemetrexed results in increased activity of SLC46A1 protein
SLC46A1 protein results in increased susceptibility to Pemetrexed
CTD PMID:21879757 NCBI chr11:78,356,527...78,362,771
Ensembl chr11:78,356,523...78,362,885
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of TNFAIP3 mRNA CTD PMID:22975265 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405
JBrowse link
G Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of TNFRSF9 mRNA CTD PMID:22975265 NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions ISO [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of TRAF1 mRNA CTD PMID:22975265 NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784
JBrowse link
G Trp53 transformation related protein 53 multiple interactions
affects response to substance
ISO TP53 protein affects the reaction [Pemetrexed results in increased expression of FAS protein]
TP53 protein affects the susceptibility to Pemetrexed
CTD PMID:15161716 PMID:17339891 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Tymp thymidine phosphorylase increases response to substance ISO TYMP protein results in increased susceptibility to Pemetrexed CTD PMID:17575230 NCBI chr15:89,255,834...89,261,282
Ensembl chr15:89,256,134...89,261,242
JBrowse link
G Tyms thymidylate synthase decreases activity
multiple interactions
affects response to substance
ISO Pemetrexed results in decreased activity of TYMS protein
TYMS protein inhibits the reaction [Pemetrexed results in increased expression of FAS protein]
TYMS affects the susceptibility to Pemetrexed; TYMS protein affects the susceptibility to Pemetrexed
CTD PMID:15161716 PMID:17339891 PMID:21742432 NCBI chr 5:30,243,544...30,279,261
Ensembl chr 5:30,263,200...30,278,615
JBrowse link
S-adenosyl-L-homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy S-adenosylhomocysteine hydrolase increases hydrolysis ISO AHCY results in increased hydrolysis of S-Adenosylhomocysteine CTD PMID:26974671 NCBI chr 2:154,901,230...154,916,417
Ensembl chr 2:154,901,230...154,916,417
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
increases abundance
EXP PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine] CTD PMID:29416063 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:149,330,443...149,353,614
Ensembl chr  X:149,330,371...149,353,634
JBrowse link
G App amyloid beta precursor protein increases expression
decreases methylation
multiple interactions
EXP S-Adenosylhomocysteine results in increased expression of APP protein
S-Adenosylhomocysteine results in decreased methylation of APP promoter
Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein
CTD PMID:19635394 PMID:22064374 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Atp7b ATPase, copper transporting, beta polypeptide increases abundance EXP ATP7B protein mutant form results in increased abundance of S-Adenosylhomocysteine CTD PMID:22945834 NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 increases expression EXP S-Adenosylhomocysteine results in increased expression of BACE1 protein CTD PMID:19635394 NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697
JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of CARM1 protein CTD PMID:33577917 NCBI chr 9:21,458,163...21,500,763
Ensembl chr 9:21,458,190...21,503,919
JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A1 mRNA CTD PMID:15983038 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Col1a2 collagen, type I, alpha 2 decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Comt catechol-O-methyltransferase decreases activity ISO S-Adenosylhomocysteine results in decreased activity of COMT protein CTD PMID:10064789 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity
multiple interactions
ISO
EXP
S-Adenosylhomocysteine results in decreased activity of DNMT1 protein
S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
CTD PMID:16037419 PMID:22064374 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
JBrowse link
G Fgf15 fibroblast growth factor 15 decreases abundance EXP FGF19 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029
G Hmbs hydroxymethylbilane synthase multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions
EXP
ISO
S-Adenosylhomocysteine results in increased expression of MMP2 mRNA; S-Adenosylhomocysteine results in increased expression of MMP2 protein
S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]
U 0126 inhibits the reaction [S-Adenosylhomocysteine results in increased expression of MMP2 protein]
CTD PMID:19770485 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases expression ISO S-Adenosylhomocysteine results in decreased expression of NFKBIA protein CTD PMID:19770485 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases abundance EXP NR0B2 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 multiple interactions
decreases methylation
decreases expression
EXP Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter]; S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
S-Adenosylhomocysteine results in decreased expression of OGG1 mRNA; S-Adenosylhomocysteine results in decreased expression of OGG1 protein
CTD PMID:22064374 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions EXP PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine] CTD PMID:29416063 NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO S-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Prmt1 protein arginine N-methyltransferase 1 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT1 protein CTD PMID:33577917 NCBI chr 7:44,626,179...44,635,844
Ensembl chr 7:44,625,413...44,635,992
JBrowse link
G Prmt5 protein arginine N-methyltransferase 5 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT5 protein CTD PMID:33577917 NCBI chr14:54,744,639...54,754,927
Ensembl chr14:54,744,644...54,754,982
JBrowse link
G Prmt6 protein arginine N-methyltransferase 6 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT6 protein CTD PMID:33577917 NCBI chr 3:110,153,420...110,158,315
Ensembl chr 3:110,153,425...110,158,314
JBrowse link
G Prmt7 protein arginine N-methyltransferase 7 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT7 protein CTD PMID:33577917 NCBI chr 8:106,937,686...106,978,326
Ensembl chr 8:106,937,568...106,979,426
JBrowse link
G Psen1 presenilin 1 multiple interactions
decreases methylation
increases expression
EXP Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter]
S-Adenosylhomocysteine results in increased expression of PSEN1 protein
CTD PMID:19635394 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973
JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 affects abundance EXP SLC19A1 protein affects the abundance of S-Adenosylhomocysteine CTD PMID:15705887 NCBI chr10:76,868,103...76,886,266
Ensembl chr10:76,868,075...76,896,836
JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions ISO S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter] CTD PMID:19770485 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 decreases expression EXP S-Adenosylhomocysteine results in decreased expression of TIMP2 protein CTD PMID:19770485 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566
JBrowse link
tolcapone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1110059G10Rik RIKEN cDNA 1110059G10 gene decreases expression ISO tolcapone results in decreased expression of RGD1311745 mRNA CTD PMID:24136188 NCBI chr 9:122,774,154...122,780,065
Ensembl chr 9:122,774,154...122,780,065
JBrowse link
G 2300009A05Rik RIKEN cDNA 2300009A05 gene decreases expression ISO Tolcapone results in decreased expression of C8H15ORF61 mRNA CTD PMID:24136188 NCBI chr 9:63,301,729...63,306,526
Ensembl chr 9:63,301,729...63,306,528
JBrowse link
G Aadac arylacetamide deacetylase decreases expression ISO tolcapone results in decreased expression of AADAC mRNA CTD PMID:24136188 NCBI chr 3:59,939,209...59,947,578
Ensembl chr 3:59,933,138...59,947,581
JBrowse link
G Aars1 alanyl-tRNA synthetase 1 increases expression ISO Tolcapone results in increased expression of AARS1 mRNA CTD PMID:24136188 NCBI chr 8:111,759,781...111,784,237
Ensembl chr 8:111,759,776...111,784,296
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity ISO tolcapone results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcd2 ATP-binding cassette, sub-family D member 2 affects binding ISO tolcapone binds to ABCD2 protein CTD PMID:19783845 NCBI chr15:91,029,874...91,076,013
Ensembl chr15:91,030,074...91,076,002
JBrowse link
G Abhd10 abhydrolase domain containing 10 affects binding ISO Tolcapone binds to ABHD10 protein CTD PMID:19783845 NCBI chr16:45,550,088...45,563,355
Ensembl chr16:45,550,088...45,563,318
JBrowse link
G Acat2 acetyl-Coenzyme A acetyltransferase 2 increases expression ISO tolcapone results in increased expression of ACAT2 mRNA CTD PMID:24136188 NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634
JBrowse link
G Acox3 acyl-Coenzyme A oxidase 3, pristanoyl affects binding ISO tolcapone binds to ACOX3 protein CTD PMID:19783845 NCBI chr 5:35,740,293...35,772,397
Ensembl chr 5:35,740,384...35,772,696
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 affects binding
decreases expression
ISO tolcapone binds to ACSL1 protein
tolcapone results in decreased expression of ACSL1 mRNA; tolcapone results in decreased expression of ACSL1 protein
CTD PMID:19783845 PMID:29688484 NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression ISO tolcapone results in decreased expression of ACSL5 protein CTD PMID:29688484 NCBI chr19:55,240,298...55,285,060
Ensembl chr19:55,240,370...55,286,152
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 increases expression ISO tolcapone results in increased expression of ACSS2 mRNA CTD PMID:24136188 NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta affects binding ISO tolcapone binds to ACTA2 protein CTD PMID:19783845 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Adprhl1 ADP-ribosylhydrolase like 1 affects binding ISO tolcapone binds to ADPRHL1 protein CTD PMID:19783845 NCBI chr 8:13,268,449...13,304,079
Ensembl chr 8:13,271,663...13,304,162
JBrowse link
G Aga aspartylglucosaminidase decreases expression ISO tolcapone results in decreased expression of AGA mRNA CTD PMID:24136188 NCBI chr 8:53,964,718...53,976,457
Ensembl chr 8:53,964,762...53,976,456
JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression ISO tolcapone results in decreased expression of AIF1 mRNA CTD PMID:24136188 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
JBrowse link
G Ak2 adenylate kinase 2 affects binding ISO tolcapone binds to AK2 protein CTD PMID:19783845 NCBI chr 4:128,887,017...128,905,322
Ensembl chr 4:128,885,751...128,905,322
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 decreases expression ISO tolcapone results in decreased expression of AKR1C3 mRNA CTD PMID:24136188 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
JBrowse link
G Akr1c6 aldo-keto reductase family 1, member C6 affects binding ISO Tolcapone binds to AKR1C1 protein CTD PMID:19783845 NCBI chr13:4,484,354...4,507,529
Ensembl chr13:4,484,305...4,507,876
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 affects binding ISO tolcapone binds to AKR1D1 protein CTD PMID:19783845 NCBI chr 6:37,506,913...37,551,856
Ensembl chr 6:37,507,108...37,545,750
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 affects binding ISO tolcapone binds to ALDH18A1 protein CTD PMID:19783845 NCBI chr19:40,538,701...40,576,907
Ensembl chr19:40,538,701...40,576,907
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 affects binding ISO tolcapone binds to ALDH1B1 protein CTD PMID:19783845 NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression ISO tolcapone results in increased expression of ALDH1L1 mRNA CTD PMID:24136188 NCBI chr 6:90,527,751...90,576,153
Ensembl chr 6:90,463,409...90,577,185
JBrowse link
G Aldh3a2 aldehyde dehydrogenase family 3, subfamily A2 affects binding ISO tolcapone binds to ALDH3A2 protein CTD PMID:19783845 NCBI chr11:61,114,240...61,158,267
Ensembl chr11:61,114,243...61,158,290
JBrowse link
G Alg13 asparagine-linked glycosylation 13 decreases expression ISO Tolcapone results in decreased expression of ALG13 mRNA CTD PMID:24136188 NCBI chr  X:143,100,962...143,157,446
Ensembl chr  X:143,100,800...143,157,446
JBrowse link
G Amfr autocrine motility factor receptor increases expression ISO tolcapone results in increased expression of AMFR mRNA CTD PMID:24136188 NCBI chr 8:94,698,216...94,739,301
Ensembl chr 8:94,698,216...94,739,470
JBrowse link
G Apmap adipocyte plasma membrane associated protein affects binding ISO tolcapone binds to APMAP protein CTD PMID:19783845 NCBI chr 2:150,425,000...150,450,487
Ensembl chr 2:150,425,000...150,450,487
JBrowse link
G Apoa1 apolipoprotein A-I affects binding ISO tolcapone binds to APOA1 protein CTD PMID:19783845 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
JBrowse link
G Apob apolipoprotein B decreases expression
decreases secretion
ISO tolcapone results in decreased expression of APOB mRNA
tolcapone results in decreased secretion of APOB protein alternative form
CTD PMID:29688484 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835
JBrowse link
G Apoc2 apolipoprotein C2 decreases expression ISO tolcapone results in decreased expression of APOC2 mRNA CTD PMID:24136188 NCBI chr 7:19,405,504...19,411,866
Ensembl chr 7:19,405,504...19,411,866
JBrowse link
G Apoe apolipoprotein E affects binding ISO tolcapone binds to APOE protein CTD PMID:19783845 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
JBrowse link
G Apool apolipoprotein O-like decreases expression ISO tolcapone results in decreased expression of APOOL mRNA CTD PMID:24136188 NCBI chr  X:111,221,049...111,282,452
Ensembl chr  X:111,221,031...111,282,452
JBrowse link
G Arf4 ARF GTPase 4 affects binding ISO tolcapone binds to ARF4 protein CTD PMID:19783845 NCBI chr14:26,359,289...26,377,997
Ensembl chr14:26,359,229...26,386,239
JBrowse link
G Arl1 ADP-ribosylation factor-like 1 affects binding ISO tolcapone binds to ARL1 protein CTD PMID:19783845 NCBI chr10:88,566,720...88,579,956
Ensembl chr10:88,566,720...88,579,956
JBrowse link
G Atad1 ATPase family, AAA domain containing 1 affects binding ISO tolcapone binds to ATAD1 protein CTD PMID:19783845 NCBI chr19:32,649,958...32,717,187
Ensembl chr19:32,649,038...32,717,186
JBrowse link
G Atad3a ATPase family, AAA domain containing 3A affects binding ISO tolcapone binds to ATAD3A protein CTD PMID:19783845 NCBI chr 4:155,825,097...155,845,579
Ensembl chr 4:155,825,098...155,845,550
JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO tolcapone results in increased expression of ATF5 mRNA CTD PMID:24136188 NCBI chr 7:44,461,680...44,466,082
Ensembl chr 7:44,461,680...44,466,082
JBrowse link
G Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide affects binding ISO tolcapone binds to ATP1B3 protein CTD PMID:19783845 NCBI chr 9:96,214,708...96,246,368
Ensembl chr 9:96,214,708...96,246,495
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta affects binding ISO tolcapone binds to ATP5F1B protein CTD PMID:19783845 NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260
JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma affects binding ISO Tolcapone binds to ATP5F1C protein CTD PMID:19783845 NCBI chr 2:10,060,841...10,085,321
Ensembl chr 2:10,060,827...10,085,321
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon decreases expression ISO tolcapone results in decreased expression of ATP5F1E mRNA CTD PMID:24136188 NCBI chr 2:174,302,868...174,305,894
Ensembl chr 2:174,302,865...174,305,898
JBrowse link
G Atp5me ATP synthase membrane subunit e affects binding
decreases expression
ISO tolcapone binds to ATP5ME protein
tolcapone results in decreased expression of ATP5ME mRNA
CTD PMID:19783845 PMID:24136188 NCBI chr 5:108,581,112...108,582,265
Ensembl chr 5:108,581,110...108,582,314
JBrowse link
G Atp5mf ATP synthase membrane subunit f affects binding ISO tolcapone binds to ATP5MF protein CTD PMID:19783845 NCBI chr 5:145,120,514...145,128,351
Ensembl chr 5:145,120,508...145,128,872
JBrowse link
G Atp5mg ATP synthase membrane subunit g decreases expression
affects binding
ISO tolcapone results in decreased expression of ATP5MG mRNA
tolcapone binds to ATP5MG protein
CTD PMID:19783845 PMID:24136188 NCBI chr 9:44,824,546...44,832,470
Ensembl chr 9:44,823,855...44,832,040
JBrowse link
G Atp5mk ATP synthase membrane subunit k decreases expression ISO Tolcapone results in decreased expression of ATP5MK mRNA CTD PMID:24136188 NCBI chr19:47,071,910...47,079,086
Ensembl chr19:47,071,903...47,079,086
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 decreases expression ISO tolcapone results in decreased expression of ATP5PF mRNA CTD PMID:24136188 NCBI chr16:84,624,754...84,632,495
Ensembl chr16:84,624,754...84,632,513
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP affects binding ISO tolcapone binds to ATP5PO protein CTD PMID:19783845 NCBI chr16:91,722,111...91,728,518
Ensembl chr16:91,722,102...91,728,575
Ensembl chr16:91,722,102...91,728,575
JBrowse link
G Auh AU RNA binding protein/enoyl-coenzyme A hydratase affects binding ISO tolcapone binds to AUH protein CTD PMID:19783845 NCBI chr13:52,989,155...53,083,742
Ensembl chr13:52,989,155...53,083,717
JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 decreases expression ISO tolcapone results in decreased expression of BBOX1 mRNA CTD PMID:24136188 NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905
JBrowse link
G Bcam basal cell adhesion molecule affects binding ISO tolcapone binds to BCAM protein CTD PMID:19783845 NCBI chr 7:19,490,063...19,504,457
Ensembl chr 7:19,490,056...19,504,941
JBrowse link
G Bcap29 B cell receptor associated protein 29 decreases expression ISO tolcapone results in decreased expression of BCAP29 mRNA CTD PMID:24136188 NCBI chr12:31,645,353...31,684,657
Ensembl chr12:31,640,966...31,684,657
JBrowse link
G Bcas2 BCAS2 pre-mRNA processing factor decreases expression ISO tolcapone results in decreased expression of BCAS2 mRNA CTD PMID:24136188 NCBI chr 3:103,078,971...103,086,479
Ensembl chr 3:103,078,971...103,086,482
JBrowse link
G Bltp1 bridge-like lipid transfer protein family member 1 increases expression ISO Tolcapone results in increased expression of BLTP1 mRNA CTD PMID:24136188 NCBI chr 3:36,917,212...37,107,182
Ensembl chr 3:36,917,253...37,107,182
JBrowse link
G Bmper BMP-binding endothelial regulator affects binding ISO tolcapone binds to BMPER protein CTD PMID:19783845 NCBI chr 9:23,134,372...23,396,511
Ensembl chr 9:23,134,372...23,396,496
JBrowse link
G Bms1 BMS1, ribosome biogenesis factor affects binding ISO tolcapone binds to BMS1 protein CTD PMID:19783845 NCBI chr 6:118,360,342...118,396,772
Ensembl chr 6:118,360,342...118,396,435
JBrowse link
G Bpgm 2,3-bisphosphoglycerate mutase decreases expression ISO tolcapone results in decreased expression of BPGM mRNA CTD PMID:24136188 NCBI chr 6:34,453,291...34,482,071
Ensembl chr 6:34,453,142...34,482,548
JBrowse link
G Btf3l4 basic transcription factor 3-like 4 decreases expression ISO tolcapone results in decreased expression of BTF3L4 mRNA CTD PMID:24136188 NCBI chr 4:108,671,489...108,691,445
Ensembl chr 4:108,671,492...108,690,811
JBrowse link
G C1d C1D nuclear receptor co-repressor decreases expression ISO tolcapone results in decreased expression of C1D mRNA CTD PMID:24136188 NCBI chr11:17,207,547...17,219,176
Ensembl chr11:17,207,579...17,219,176
JBrowse link
G C1galt1c1 C1GALT1-specific chaperone 1 decreases expression ISO tolcapone results in decreased expression of C1GALT1C1 mRNA CTD PMID:24136188 NCBI chr  X:37,719,660...37,724,020
Ensembl chr  X:37,719,662...37,723,964
JBrowse link
G C4b complement C4B (Chido blood group) increases expression ISO tolcapone results in increased expression of C4B mRNA CTD PMID:24136188 NCBI chr17:34,947,249...34,962,876
Ensembl chr17:34,947,354...34,962,856
JBrowse link
G C8a complement component 8, alpha polypeptide increases expression ISO tolcapone results in increased expression of C8A mRNA CTD PMID:24136188 NCBI chr 4:104,672,876...104,733,684
Ensembl chr 4:104,672,876...104,733,595
JBrowse link
G Cbr4 carbonyl reductase 4 decreases expression ISO tolcapone results in decreased expression of CBR4 mRNA CTD PMID:24136188 NCBI chr 8:61,940,768...61,956,534
Ensembl chr 8:61,940,768...61,959,728
JBrowse link
G Ccnl2 cyclin L2 increases expression ISO tolcapone results in increased expression of CCNL2 mRNA CTD PMID:24136188 NCBI chr 4:155,894,468...155,909,005
Ensembl chr 4:155,896,946...155,909,000
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 affects binding ISO tolcapone binds to CCT7 protein CTD PMID:19783845 NCBI chr 6:85,428,487...85,445,459
Ensembl chr 6:85,428,496...85,445,457
JBrowse link
G Cd36 CD36 molecule increases expression ISO tolcapone results in increased expression of CD36 mRNA CTD PMID:29688484 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cfb complement factor B increases expression ISO tolcapone results in increased expression of CFB mRNA CTD PMID:24136188 NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494
JBrowse link
G Chchd1 coiled-coil-helix-coiled-coil-helix domain containing 1 decreases expression ISO tolcapone results in decreased expression of CHCHD1 mRNA CTD PMID:24136188 NCBI chr14:20,753,095...20,754,493
Ensembl chr14:20,753,074...20,754,493
JBrowse link
G Chchd7 coiled-coil-helix-coiled-coil-helix domain containing 7 decreases expression ISO tolcapone results in decreased expression of CHCHD7 mRNA CTD PMID:24136188 NCBI chr 4:3,938,847...3,951,382
Ensembl chr 4:3,938,888...3,951,046
JBrowse link
G Chrac1 chromatin accessibility complex 1 decreases expression ISO tolcapone results in decreased expression of CHRAC1 mRNA CTD PMID:24136188 NCBI chr15:72,962,261...72,965,924
Ensembl chr15:72,962,241...72,969,403
JBrowse link
G Churc1 churchill domain containing 1 decreases expression ISO tolcapone results in decreased expression of CHURC1 mRNA CTD PMID:24136188 NCBI chr12:76,812,312...76,829,954
Ensembl chr12:76,812,312...76,829,954
JBrowse link
G Ciao2a cytosolic iron-sulfur assembly component 2A decreases expression ISO tolcapone results in decreased expression of CIAO2A mRNA CTD PMID:24136188 NCBI chr 9:66,033,878...66,046,250
Ensembl chr 9:66,033,893...66,046,237
JBrowse link
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A increases expression ISO tolcapone results in increased expression of CIDEA mRNA CTD PMID:29688484 NCBI chr18:67,476,634...67,500,864
Ensembl chr18:67,476,674...67,500,855
JBrowse link
G Cisd1 CDGSH iron sulfur domain 1 affects binding ISO tolcapone binds to CISD1 protein CTD PMID:19783845 NCBI chr10:71,166,324...71,180,679
Ensembl chr10:71,166,310...71,180,784
JBrowse link
G Clec4a3 C-type lectin domain family 4, member a3 decreases expression ISO Tolcapone results in decreased expression of CLEC4A3 mRNA CTD PMID:24136188 NCBI chr 6:122,929,474...122,946,837
Ensembl chr 6:122,929,474...122,946,834
JBrowse link
G Cltc clathrin heavy chain affects binding ISO tolcapone binds to CLTC protein CTD PMID:19783845 NCBI chr11:86,585,178...86,648,637
Ensembl chr11:86,585,177...86,648,391
JBrowse link
G Cnih4 cornichon family AMPA receptor auxiliary protein 4 decreases expression ISO tolcapone results in decreased expression of CNIH4 mRNA CTD PMID:24136188 NCBI chr 1:180,977,437...180,996,559
Ensembl chr 1:180,972,258...180,996,559
JBrowse link
G Commd6 COMM domain containing 6 decreases expression ISO tolcapone results in decreased expression of COMMD6 mRNA CTD PMID:24136188 NCBI chr14:101,871,202...101,877,907
Ensembl chr14:101,870,417...101,878,122
JBrowse link
G Comt catechol-O-methyltransferase decreases activity
multiple interactions
increases methylation
affects binding
EXP
ISO
tolcapone results in decreased activity of COMT protein
[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]; [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine; tolcapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]
COMT protein results in increased methylation of tolcapone
tolcapone binds to COMT protein
CTD PMID:2089102 PMID:7566641 PMID:7768073 PMID:8821542 PMID:9333106 More... NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
G Copg1 coatomer protein complex, subunit gamma 1 affects binding ISO tolcapone binds to COPG1 protein CTD PMID:19783845 NCBI chr 6:87,864,801...87,890,577
Ensembl chr 6:87,864,796...87,890,577
JBrowse link
G Copg2 coatomer protein complex, subunit gamma 2 decreases expression ISO tolcapone results in decreased expression of COPG2 mRNA CTD PMID:24136188 NCBI chr 6:30,747,552...30,873,712
Ensembl chr 6:30,747,553...30,873,729
JBrowse link
G Coq10a coenzyme Q10A decreases expression ISO tolcapone results in decreased expression of COQ10A mRNA CTD PMID:24136188 NCBI chr10:128,198,965...128,204,849
Ensembl chr10:128,198,969...128,204,866
JBrowse link
G Coq3 coenzyme Q3 methyltransferase decreases expression ISO tolcapone results in decreased expression of COQ3 mRNA CTD PMID:24136188 NCBI chr 4:21,879,646...21,912,163
Ensembl chr 4:21,879,673...21,912,162
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C affects binding
decreases expression
ISO tolcapone binds to COX6C protein
tolcapone results in decreased expression of COX6C mRNA
CTD PMID:19783845 PMID:24136188 NCBI chr15:35,932,122...35,938,392
Ensembl chr15:35,926,032...35,938,392
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 decreases expression ISO tolcapone results in decreased expression of COX7A2 mRNA CTD PMID:24136188 NCBI chr 9:79,662,523...79,667,135
Ensembl chr 9:79,662,643...79,667,160
JBrowse link
G Cox7b cytochrome c oxidase subunit 7B decreases expression ISO tolcapone results in decreased expression of COX7B mRNA CTD PMID:24136188 NCBI chr  X:105,059,306...105,066,056
Ensembl chr  X:105,059,306...105,066,056
JBrowse link
G Cp ceruloplasmin increases expression ISO tolcapone results in increased expression of CP mRNA CTD PMID:24136188 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309
JBrowse link
G Crem cAMP responsive element modulator decreases expression ISO tolcapone results in decreased expression of CREM mRNA CTD PMID:24136188 NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748
JBrowse link
G Crip2 cysteine rich protein 2 increases expression ISO tolcapone results in increased expression of CRIP2 mRNA CTD PMID:24136188 NCBI chr12:113,103,856...113,109,126
Ensembl chr12:113,103,856...113,109,126
JBrowse link
G Cse1l chromosome segregation 1 like affects binding ISO tolcapone binds to CSE1L protein CTD PMID:19783845 NCBI chr 2:166,747,961...166,788,309
Ensembl chr 2:166,747,960...166,788,309
JBrowse link
G Cstb cystatin B decreases expression ISO tolcapone results in decreased expression of CSTB mRNA CTD PMID:24136188 NCBI chr10:78,261,504...78,263,456
Ensembl chr10:78,261,503...78,263,456
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO Tolcapone results in increased expression of CXCL8 mRNA CTD PMID:32816093 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cyc1 cytochrome c-1 affects binding ISO tolcapone binds to CYC1 protein CTD PMID:19783845 NCBI chr15:76,227,711...76,230,460
Ensembl chr15:76,227,723...76,230,460
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Tolcapone results in decreased activity of CYP1A1 protein
CTD PMID:18493746 PMID:33814510 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
tolcapone results in increased expression of CYP1A2 mRNA
CTD PMID:18493746 PMID:24136188 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Tolcapone results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression ISO tolcapone results in increased expression of CYP51 mRNA CTD PMID:24136188 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746
JBrowse link
G Dap death-associated protein increases expression ISO tolcapone results in increased expression of DAP mRNA CTD PMID:24136188 NCBI chr15:31,224,531...31,274,484
Ensembl chr15:31,224,460...31,274,487
JBrowse link
G Dctd dCMP deaminase affects binding ISO tolcapone binds to DCTD protein CTD PMID:19783845 NCBI chr 8:48,552,127...48,594,702
Ensembl chr 8:48,552,127...48,606,268
JBrowse link
G Ddost dolichyl-di-phosphooligosaccharide-protein glycotransferase affects binding ISO tolcapone binds to DDOST protein CTD PMID:19783845 NCBI chr 4:138,032,049...138,039,930
Ensembl chr 4:138,032,041...138,039,939
JBrowse link
G Ddx18 DEAD box helicase 18 affects binding ISO tolcapone binds to DDX18 protein CTD PMID:19783845 NCBI chr 1:121,481,564...121,495,709
Ensembl chr 1:121,481,564...121,495,718
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects binding
increases expression
ISO tolcapone binds to DHCR24 protein
tolcapone results in increased expression of DHCR24 mRNA
CTD PMID:19783845 PMID:24136188 NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects binding ISO tolcapone binds to DHCR7 protein CTD PMID:19783845 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147
JBrowse link
G Dmac1 distal membrane arm assembly complex 1 decreases expression ISO tolcapone results in decreased expression of DMAC1 mRNA CTD PMID:24136188 NCBI chr 4:75,195,588...75,196,529
Ensembl chr 4:75,195,591...75,196,542
JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 decreases expression ISO tolcapone results in decreased expression of DNAJC15 mRNA CTD PMID:24136188 NCBI chr14:78,063,657...78,112,357
Ensembl chr14:78,058,121...78,112,565
JBrowse link
G Dock11 dedicator of cytokinesis 11 decreases expression ISO tolcapone results in decreased expression of DOCK11 mRNA CTD PMID:24136188 NCBI chr  X:35,150,924...35,340,223
Ensembl chr  X:35,152,485...35,340,215
JBrowse link
G Dpm3 dolichyl-phosphate mannosyltransferase polypeptide 3 decreases expression ISO tolcapone results in decreased expression of DPM3 mRNA CTD PMID:24136188 NCBI chr 3:89,166,567...89,174,386
Ensembl chr 3:89,166,665...89,174,386
JBrowse link
G Dpy30 dpy-30, histone methyltransferase complex regulatory subunit decreases expression ISO tolcapone results in decreased expression of DPY30 mRNA CTD PMID:24136188 NCBI chr17:74,606,469...74,630,939
Ensembl chr17:74,606,469...74,630,939
JBrowse link
G Dtymk deoxythymidylate kinase decreases expression ISO tolcapone results in decreased expression of DTYMK mRNA CTD PMID:24136188 NCBI chr 1:93,720,298...93,730,246
Ensembl chr 1:93,720,298...93,729,656
JBrowse link
G Dynll1 dynein light chain LC8-type 1 decreases expression ISO tolcapone results in decreased expression of DYNLL1 mRNA CTD PMID:24136188 NCBI chr 5:115,435,129...115,438,995
Ensembl chr 5:115,435,169...115,439,058
JBrowse link
G Dynlt3 dynein light chain Tctex-type 3 decreases expression ISO tolcapone results in decreased expression of DYNLT3 mRNA CTD PMID:24136188 NCBI chr  X:9,520,509...9,529,222
Ensembl chr  X:9,520,506...9,529,242
JBrowse link
G Ebp EBP cholestenol delta-isomerase increases expression ISO tolcapone results in increased expression of EBP mRNA CTD PMID:24136188 NCBI chr  X:8,051,568...8,059,751
Ensembl chr  X:8,051,568...8,059,751
JBrowse link
G Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial affects binding ISO tolcapone binds to ECHS1 protein CTD PMID:19783845 NCBI chr 7:139,685,623...139,696,334
Ensembl chr 7:139,685,623...139,696,389
JBrowse link
G Eloc elongin C decreases expression ISO tolcapone results in decreased expression of ELOC mRNA CTD PMID:24136188 NCBI chr 1:16,711,949...16,727,652
Ensembl chr 1:16,711,949...16,727,266
JBrowse link
G Ereg epiregulin decreases expression ISO Tolcapone results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
JBrowse link
G F5 coagulation factor V increases expression ISO tolcapone results in increased expression of F5 mRNA CTD PMID:24136188 NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846
JBrowse link
G Fam162a family with sequence similarity 162, member A affects binding ISO tolcapone binds to FAM162A protein CTD PMID:19783845 NCBI chr16:35,864,214...35,891,931
Ensembl chr16:35,864,131...35,891,964
JBrowse link
G Fbll1 fibrillarin-like 1 affects binding ISO tolcapone binds to FBLL1 protein CTD PMID:19783845 NCBI chr11:35,688,207...35,689,711
Ensembl chr11:35,688,209...35,689,711
JBrowse link
G Fcf1 FCF1 rRNA processing protein decreases expression ISO tolcapone results in decreased expression of FCF1 mRNA CTD PMID:24136188 NCBI chr12:85,017,704...85,030,077
Ensembl chr12:85,017,671...85,030,077
JBrowse link
G Fga fibrinogen alpha chain affects binding ISO tolcapone binds to FGA protein CTD PMID:19783845 NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934
JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 decreases expression ISO tolcapone results in decreased expression of FMC1 mRNA CTD PMID:24136188 NCBI chr 6:38,511,796...38,516,384
Ensembl chr 6:38,510,437...38,516,384
JBrowse link
G Gcdh glutaryl-Coenzyme A dehydrogenase affects binding ISO tolcapone binds to GCDH protein CTD PMID:19783845 NCBI chr 8:85,613,016...85,629,378
Ensembl chr 8:85,613,022...85,620,550
JBrowse link
G Glg1 golgi apparatus protein 1 affects binding ISO tolcapone binds to GLG1 protein CTD PMID:19783845 NCBI chr 8:111,879,916...111,985,842
Ensembl chr 8:111,881,053...111,985,848
JBrowse link
G Gm20348 predicted gene, 20348 decreases expression ISO Tolcapone results in decreased expression of TP53I3 mRNA CTD PMID:24136188 NCBI chr12:4,860,475...4,867,155
Ensembl chr12:4,860,494...4,867,142
JBrowse link
G Gm5617 predicted gene 5617 decreases expression ISO Tolcapone results in decreased expression of C8H11ORF71 mRNA CTD PMID:24136188 NCBI chr 9:48,406,643...48,407,275
Ensembl chr 9:48,406,742...48,407,272
JBrowse link
G Gmfg glia maturation factor, gamma decreases expression ISO tolcapone results in decreased expression of GMFG mRNA CTD PMID:24136188 NCBI chr 7:28,136,894...28,147,655
Ensembl chr 7:28,136,872...28,147,658
JBrowse link
G Gng10 guanine nucleotide binding protein (G protein), gamma 10 decreases expression ISO tolcapone results in decreased expression of GNG10 mRNA CTD PMID:24136188 NCBI chr 4:59,035,156...59,041,899
Ensembl chr 4:59,035,088...59,041,903
JBrowse link
G Gng5 G protein subunit gamma 5 decreases expression ISO tolcapone results in decreased expression of GNG5 mRNA CTD PMID:24136188 NCBI chr 3:146,205,591...146,211,298
Ensembl chr 3:146,205,562...146,211,327
JBrowse link
G Gpc3 glypican 3 affects binding ISO tolcapone binds to GPC3 protein CTD PMID:19783845 NCBI chr  X:51,361,303...51,702,851
Ensembl chr  X:51,361,303...51,702,827
JBrowse link
G Gtf2h5 general transcription factor IIH, polypeptide 5 decreases expression ISO tolcapone results in decreased expression of GTF2H5 mRNA CTD PMID:24136188 NCBI chr17:6,130,103...6,135,763
Ensembl chr17:6,130,061...6,136,792
JBrowse link
G H2az2 H2A.Z histone variant 2 affects binding ISO Tolcapone binds to H2AZ2 protein CTD PMID:19783845 NCBI chr11:6,377,226...6,394,511
Ensembl chr11:6,377,229...6,394,443
JBrowse link
G H4c8 H4 clustered histone 8 decreases expression ISO Tolcapone results in decreased expression of HIST1H4B mRNA CTD PMID:24136188 NCBI chr13:23,715,214...23,715,648
Ensembl chr13:23,715,220...23,715,689
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain affects binding ISO tolcapone binds to HBB protein CTD PMID:19783845
G Hc hemolytic complement increases expression ISO tolcapone results in increased expression of C5 mRNA CTD PMID:24136188 NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450
JBrowse link
G Higd1a HIG1 domain family, member 1A decreases expression ISO tolcapone results in decreased expression of HIGD1A mRNA CTD PMID:24136188 NCBI chr 9:121,677,623...121,686,862
Ensembl chr 9:121,677,629...121,687,428
JBrowse link
G Hint3 histidine triad nucleotide binding protein 3 decreases expression ISO tolcapone results in decreased expression of HINT3 mRNA CTD PMID:24136188 NCBI chr10:30,479,191...30,499,526
Ensembl chr10:30,484,137...30,505,628
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 affects binding ISO tolcapone binds to HNRNPH1 protein CTD PMID:19783845 NCBI chr11:50,266,084...50,277,355
Ensembl chr11:50,267,817...50,277,355
JBrowse link
G Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 affects binding ISO tolcapone binds to HSD17B11 protein CTD PMID:19783845 NCBI chr 5:104,137,631...104,169,662
Ensembl chr 5:104,137,628...104,169,785
JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 affects binding ISO tolcapone binds to HSD17B12 protein CTD PMID:19783845 NCBI chr 2:93,863,042...93,988,254
Ensembl chr 2:93,863,034...93,988,309
JBrowse link
G Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 affects binding ISO tolcapone binds to HSD17B13 protein CTD PMID:19783845 NCBI chr 5:104,103,308...104,125,254
Ensembl chr 5:104,103,306...104,125,276
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects binding ISO tolcapone binds to HSD17B4 protein CTD PMID:19783845 NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 increases expression ISO tolcapone results in increased expression of HSDL2 mRNA CTD PMID:24136188 NCBI chr 4:59,581,515...59,618,694
Ensembl chr 4:59,581,563...59,618,689
JBrowse link
G Iftap intraflagellar transport associated protein decreases expression ISO Tolcapone results in decreased expression of IFTAP mRNA CTD PMID:24136188 NCBI chr 2:101,391,124...101,459,376
Ensembl chr 2:101,391,126...101,479,877
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO tolcapone results in increased expression of IGFBP1 mRNA CTD PMID:24136188 NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546
JBrowse link
G Il24 interleukin 24 decreases expression ISO Tolcapone results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
JBrowse link
G Ipo7 importin 7 affects binding ISO tolcapone binds to IPO7 protein CTD PMID:19783845 NCBI chr 7:109,617,522...109,655,816
Ensembl chr 7:109,617,481...109,655,816
JBrowse link
G Itm2a integral membrane protein 2A affects binding ISO tolcapone binds to ITM2A protein CTD PMID:19783845 NCBI chr  X:106,440,801...106,446,966
Ensembl chr  X:106,440,705...106,446,982
JBrowse link
G Jagn1 jagunal homolog 1 affects binding ISO tolcapone binds to JAGN1 protein CTD PMID:19783845 NCBI chr 6:113,419,478...113,425,190
Ensembl chr 6:113,419,530...113,425,190
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO tolcapone results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Kng1 kininogen 1 increases expression ISO Tolcapone results in increased expression of KNG1 mRNA CTD PMID:24136188 NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828
JBrowse link
G Lage3 L antigen family, member 3 decreases expression ISO tolcapone results in decreased expression of LAGE3 mRNA CTD PMID:24136188 NCBI chr  X:73,395,768...73,397,224
Ensembl chr  X:73,394,882...73,397,224
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression ISO tolcapone results in increased expression of LBP mRNA CTD PMID:24136188 NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772
JBrowse link
G Lrrc59 leucine rich repeat containing 59 affects binding ISO tolcapone binds to LRRC59 protein CTD PMID:19783845 NCBI chr11:94,520,603...94,536,049
Ensembl chr11:94,520,593...94,536,042
JBrowse link
G Lsm3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO tolcapone results in decreased expression of LSM3 mRNA CTD PMID:24136188 NCBI chr 6:91,493,017...91,499,602
Ensembl chr 6:91,492,910...91,499,607
JBrowse link
G Lsm5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO tolcapone results in decreased expression of LSM5 mRNA CTD PMID:24136188 NCBI chr 6:56,678,048...56,681,684
Ensembl chr 6:56,678,048...56,681,695
JBrowse link
G Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO tolcapone results in decreased expression of LSM7 mRNA CTD PMID:24136188 NCBI chr10:80,688,659...80,691,043
Ensembl chr10:80,688,655...80,691,043
JBrowse link
G Magoh mago homolog, exon junction complex core component decreases expression ISO tolcapone results in decreased expression of MAGOH mRNA CTD PMID:24136188 NCBI chr 4:107,736,952...107,744,621
Ensembl chr 4:107,736,952...107,744,621
JBrowse link
G Masp1 MBL associated serine protease 1 increases expression ISO tolcapone results in increased expression of MASP1 mRNA CTD PMID:24136188 NCBI chr16:23,261,778...23,340,127
Ensembl chr16:23,268,167...23,339,565
JBrowse link
G Matr3 matrin 3 decreases expression ISO tolcapone results in decreased expression of MATR3 mRNA CTD PMID:24136188 NCBI chr18:35,686,462...35,724,526
Ensembl chr18:35,695,191...35,726,888
JBrowse link
G Mcee methylmalonyl CoA epimerase decreases expression ISO tolcapone results in decreased expression of MCEE mRNA CTD PMID:24136188 NCBI chr 7:64,042,370...64,061,869
Ensembl chr 7:64,042,355...64,061,873
JBrowse link
G Mcts1 malignant T cell amplified sequence 1 decreases expression ISO tolcapone results in decreased expression of MCTS1 mRNA CTD PMID:24136188 NCBI chr  X:37,653,682...37,702,401
Ensembl chr  X:37,689,455...37,702,303
JBrowse link
G Med21 mediator complex subunit 21 decreases expression ISO tolcapone results in decreased expression of MED21 mRNA CTD PMID:24136188 NCBI chr 6:146,544,077...146,552,098
Ensembl chr 6:146,544,045...146,552,230
JBrowse link
G Med28 mediator complex subunit 28 decreases expression ISO tolcapone results in decreased expression of MED28 mRNA CTD PMID:24136188 NCBI chr 5:45,677,571...45,686,626
Ensembl chr 5:45,677,571...45,686,618
JBrowse link
G Med31 mediator complex subunit 31 decreases expression ISO tolcapone results in decreased expression of MED31 mRNA CTD PMID:24136188 NCBI chr11:72,102,550...72,106,418
Ensembl chr11:72,102,550...72,106,418
JBrowse link
G Met met proto-oncogene increases expression ISO Tolcapone results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
JBrowse link
G Mettl5 methyltransferase 5, N6-adenosine decreases expression ISO tolcapone results in decreased expression of METTL5 mRNA CTD PMID:24136188 NCBI chr 2:69,701,539...69,717,961
Ensembl chr 2:69,701,542...69,715,959
JBrowse link
G Mfsd5 major facilitator superfamily domain containing 5 decreases expression ISO tolcapone results in decreased expression of MFSD5 mRNA CTD PMID:24136188 NCBI chr15:102,187,891...102,190,179
Ensembl chr15:102,187,889...102,190,189
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 affects binding ISO tolcapone binds to MGST1 protein CTD PMID:19783845 NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753
JBrowse link
G Mia3 MIA SH3 domain ER export factor 3 decreases expression ISO tolcapone results in decreased expression of MIA3 mRNA CTD PMID:24136188 NCBI chr 1:183,107,091...183,151,091
Ensembl chr 1:183,107,682...183,150,894
JBrowse link
G Mkks McKusick-Kaufman syndrome decreases expression ISO tolcapone results in decreased expression of MKKS mRNA CTD PMID:24136188 NCBI chr 2:136,715,700...136,733,422
Ensembl chr 2:136,715,700...136,733,309
JBrowse link
G Mkrn1 makorin, ring finger protein, 1 decreases expression ISO tolcapone results in decreased expression of MKRN1 mRNA CTD PMID:24136188 NCBI chr 6:39,374,738...39,400,480
Ensembl chr 6:39,374,738...39,397,396
JBrowse link
G Mmadhc methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria decreases expression ISO tolcapone results in decreased expression of MMADHC mRNA CTD PMID:24136188 NCBI chr 2:50,169,893...50,189,033
Ensembl chr 2:50,169,893...50,186,813
JBrowse link
G Mrpl1 mitochondrial ribosomal protein L1 decreases expression ISO tolcapone results in decreased expression of MRPL1 mRNA CTD PMID:24136188 NCBI chr 5:96,357,357...96,414,586
Ensembl chr 5:96,357,352...96,414,586
JBrowse link
G Mrpl13 mitochondrial ribosomal protein L13 decreases expression ISO tolcapone results in decreased expression of MRPL13 mRNA CTD PMID:24136188 NCBI chr15:55,397,491...55,420,708
Ensembl chr15:55,397,490...55,421,144
JBrowse link
G Mrpl14 mitochondrial ribosomal protein L14 decreases expression ISO tolcapone results in decreased expression of MRPL14 mRNA CTD PMID:24136188 NCBI chr17:45,991,689...46,009,421
Ensembl chr17:45,997,248...46,009,421
JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 decreases expression ISO tolcapone results in decreased expression of MRPL18 mRNA CTD PMID:24136188 NCBI chr17:13,130,232...13,136,674
Ensembl chr17:13,130,236...13,135,232
JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 decreases expression ISO tolcapone results in decreased expression of MRPL20 mRNA CTD PMID:24136188 NCBI chr 4:155,887,335...155,893,288
Ensembl chr 4:155,887,335...155,894,432
JBrowse link
G Mrpl22 mitochondrial ribosomal protein L22 decreases expression ISO tolcapone results in decreased expression of MRPL22 mRNA CTD PMID:24136188 NCBI chr11:58,060,850...58,070,406
Ensembl chr11:58,062,487...58,070,391
JBrowse link
G Mrpl23 mitochondrial ribosomal protein L23 decreases expression ISO tolcapone results in decreased expression of MRPL23 mRNA CTD PMID:24136188 NCBI chr 7:142,086,423...142,094,484
Ensembl chr 7:142,086,423...142,094,484
JBrowse link
G Mrpl30 mitochondrial ribosomal protein L30 decreases expression ISO tolcapone results in decreased expression of MRPL30 mRNA CTD PMID:24136188 NCBI chr 1:37,929,558...37,937,419
Ensembl chr 1:37,929,558...37,937,616
JBrowse link
G Mrpl32 mitochondrial ribosomal protein L32 decreases expression ISO tolcapone results in decreased expression of MRPL32 mRNA CTD PMID:24136188 NCBI chr13:14,784,886...14,787,622
Ensembl chr13:14,782,769...14,787,750
JBrowse link
G Mrpl36 mitochondrial ribosomal protein L36 decreases expression ISO tolcapone results in decreased expression of MRPL36 mRNA CTD PMID:24136188 NCBI chr13:73,479,128...73,480,297
Ensembl chr13:73,476,632...73,480,297
JBrowse link
G Mrpl40 mitochondrial ribosomal protein L40 decreases expression ISO tolcapone results in decreased expression of MRPL40 mRNA CTD PMID:24136188 NCBI chr16:18,690,767...18,695,875
Ensembl chr16:18,690,768...18,695,612
JBrowse link
G Mrpl53 mitochondrial ribosomal protein L53 decreases expression ISO tolcapone results in decreased expression of MRPL53 mRNA CTD PMID:24136188 NCBI chr 6:83,086,089...83,086,913
Ensembl chr 6:83,086,021...83,086,920
JBrowse link
G Mrps14 mitochondrial ribosomal protein S14 decreases expression ISO tolcapone results in decreased expression of MRPS14 mRNA CTD PMID:24136188 NCBI chr 1:160,022,785...160,028,756
Ensembl chr 1:160,022,785...160,029,740
JBrowse link
G Mrps18c mitochondrial ribosomal protein S18C decreases expression ISO tolcapone results in decreased expression of MRPS18C mRNA CTD PMID:24136188 NCBI chr 5:100,946,625...100,952,333
Ensembl chr 5:100,946,493...100,952,337
JBrowse link
G Mrps24 mitochondrial ribosomal protein S24 decreases expression ISO tolcapone results in decreased expression of MRPS24 mRNA CTD PMID:24136188 NCBI chr11:5,653,982...5,657,701
Ensembl chr11:5,653,983...5,665,680
JBrowse link
G Mrps33 mitochondrial ribosomal protein S33 decreases expression ISO tolcapone results in decreased expression of MRPS33 mRNA CTD PMID:24136188 NCBI chr 6:39,778,738...39,787,870
Ensembl chr 6:39,778,738...39,787,922
JBrowse link
G Mrps36 mitochondrial ribosomal protein S36 decreases expression ISO Tolcapone results in decreased expression of KGD4 mRNA CTD PMID:24136188 NCBI chr13:100,872,448...100,881,167
Ensembl chr13:100,872,463...100,881,167
JBrowse link
G Mtap methylthioadenosine phosphorylase affects binding ISO tolcapone binds to MTAP protein CTD PMID:19783845 NCBI chr 4:89,055,607...89,099,327
Ensembl chr 4:89,055,359...89,099,318
JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO tolcapone results in increased expression of MTTP protein CTD PMID:29688484 NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729
JBrowse link
G Mvk mevalonate kinase increases expression ISO tolcapone results in increased expression of MVK mRNA CTD PMID:24136188 NCBI chr 5:114,582,324...114,598,652
Ensembl chr 5:114,582,330...114,598,652
JBrowse link
G Naa20 N(alpha)-acetyltransferase 20, NatB catalytic subunit decreases expression ISO tolcapone results in decreased expression of NAA20 mRNA CTD PMID:24136188 NCBI chr 2:145,743,454...145,758,345
Ensembl chr 2:145,744,019...145,758,345
JBrowse link
G Nat10 N-acetyltransferase 10 affects binding ISO tolcapone binds to NAT10 protein CTD PMID:19783845 NCBI chr 2:103,551,603...103,593,292
Ensembl chr 2:103,551,601...103,591,615
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 decreases expression ISO tolcapone results in decreased expression of NDUFA1 mRNA CTD PMID:24136188 NCBI chr  X:36,451,241...36,454,891
Ensembl chr  X:36,451,241...36,454,816
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 decreases expression ISO tolcapone results in decreased expression of NDUFA2 mRNA CTD PMID:24136188 NCBI chr18:36,875,385...36,877,640
Ensembl chr18:36,875,385...36,877,610
JBrowse link
G Ndufa6 NADH:ubiquinone oxidoreductase subunit A6 decreases expression ISO tolcapone results in decreased expression of NDUFA6 mRNA CTD PMID:24136188 NCBI chr15:82,234,342...82,238,438
Ensembl chr15:82,234,341...82,238,523
JBrowse link
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 decreases expression ISO tolcapone results in decreased expression of NDUFA7 mRNA CTD PMID:24136188 NCBI chr17:34,043,546...34,057,290
Ensembl chr17:34,043,546...34,057,291
JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 affects binding ISO tolcapone binds to NDUFA9 protein CTD PMID:19783845 NCBI chr 6:126,798,826...126,826,107
Ensembl chr 6:126,798,684...126,826,099
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 decreases expression ISO tolcapone results in decreased expression of NDUFB6 mRNA CTD PMID:24136188 NCBI chr 4:40,270,591...40,279,421
Ensembl chr 4:40,270,591...40,279,421
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 decreases expression ISO tolcapone results in decreased expression of NDUFC2 mRNA CTD PMID:24136188 NCBI chr 7:97,049,210...97,057,007
Ensembl chr 7:97,049,210...97,057,009
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase core subunit S4 decreases expression ISO tolcapone results in decreased expression of NDUFS4 mRNA CTD PMID:24136188 NCBI chr13:114,424,331...114,524,630
Ensembl chr13:114,424,331...114,524,794
JBrowse link
G Ndufs5 NADH:ubiquinone oxidoreductase core subunit S5 decreases expression ISO tolcapone results in decreased expression of NDUFS5 mRNA CTD PMID:24136188 NCBI chr 4:123,606,503...123,611,979
Ensembl chr 4:123,606,503...123,611,995
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases expression ISO tolcapone results in decreased expression of NFE2L2 mRNA CTD PMID:28526448 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nipsnap1 nipsnap homolog 1 affects binding ISO tolcapone binds to NIPSNAP1 protein CTD PMID:19783845 NCBI chr11:4,823,951...4,844,201
Ensembl chr11:4,823,951...4,844,200
JBrowse link
G Nipsnap2 nipsnap homolog 2 affects binding ISO tolcapone binds to NIPSNAP2 protein CTD PMID:19783845 NCBI chr 5:129,802,080...129,835,391
Ensembl chr 5:129,802,127...129,835,391
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 decreases expression ISO tolcapone results in decreased expression of NME3 mRNA CTD PMID:24136188 NCBI chr17:25,115,474...25,116,505
Ensembl chr17:25,115,474...25,116,496
JBrowse link
G Nop56 NOP56 ribonucleoprotein affects binding ISO tolcapone binds to NOP56 protein CTD PMID:19783845 NCBI chr 2:130,112,904...130,121,233
Ensembl chr 2:130,116,350...130,121,233
JBrowse link
G Nphp1 nephronophthisis 1 (juvenile) homolog (human) decreases expression ISO tolcapone results in decreased expression of NPHP1 mRNA CTD PMID:24136188 NCBI chr 2:127,582,652...127,630,833
Ensembl chr 2:127,582,652...127,630,817
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor increases expression ISO tolcapone results in increased expression of NPLOC4 mRNA CTD PMID:24136188 NCBI chr11:120,270,624...120,328,526
Ensembl chr11:120,271,196...120,328,534
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO tolcapone results in decreased expression of NR3C1 mRNA CTD PMID:24136188 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
JBrowse link
G Nupr2 nuclear protein transcriptional regulator 2 decreases expression ISO tolcapone results in decreased expression of NUPR2 mRNA CTD PMID:24136188 NCBI chr 5:129,937,381...129,942,629
Ensembl chr 5:129,937,381...129,942,630
JBrowse link
G P4ha1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide affects binding ISO tolcapone binds to P4HA1 protein CTD PMID:19783845 NCBI chr10:59,159,019...59,209,126
Ensembl chr10:59,159,118...59,209,126
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO tolcapone results in decreased expression of PCNA mRNA CTD PMID:24136188 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pcx pyruvate carboxylase affects binding ISO tolcapone binds to PC protein CTD PMID:19783845 NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780
JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1, choline, alpha isoform affects binding ISO tolcapone binds to PCYT1A protein CTD PMID:19783845 NCBI chr16:32,249,739...32,293,883
Ensembl chr16:32,249,739...32,293,888
JBrowse link
G Pdzd11 PDZ domain containing 11 decreases expression ISO tolcapone results in decreased expression of PDZD11 mRNA CTD PMID:24136188 NCBI chr  X:99,665,949...99,673,667
Ensembl chr  X:99,666,489...99,670,174
JBrowse link
G Pfdn1 prefoldin 1 decreases expression ISO tolcapone results in decreased expression of PFDN1 mRNA CTD PMID:24136188 NCBI chr18:36,536,732...36,587,548
Ensembl chr18:36,536,729...36,587,577
JBrowse link
G Pfdn5 prefoldin 5 decreases expression ISO tolcapone results in decreased expression of PFDN5 mRNA CTD PMID:24136188 NCBI chr15:102,234,551...102,239,925
Ensembl chr15:102,234,551...102,240,308
JBrowse link
G Pgm1 phosphoglucomutase 1 increases expression ISO tolcapone results in increased expression of PGM1 mRNA CTD PMID:24136188 NCBI chr 4:99,786,648...99,844,491
Ensembl chr 4:99,786,611...99,844,491
JBrowse link
G Pgr progesterone receptor multiple interactions ISO tolcapone binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
JBrowse link
G Pigp phosphatidylinositol glycan anchor biosynthesis, class P decreases expression ISO tolcapone results in decreased expression of PIGP mRNA CTD PMID:24136188 NCBI chr16:94,159,622...94,171,874
Ensembl chr16:94,159,622...94,172,701
JBrowse link
G Pigs phosphatidylinositol glycan anchor biosynthesis, class S affects binding ISO tolcapone binds to PIGS protein CTD PMID:19783845 NCBI chr11:78,219,272...78,233,602
Ensembl chr11:78,219,241...78,233,608
JBrowse link
G Pin4 peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin) decreases expression ISO tolcapone results in decreased expression of PIN4 mRNA CTD PMID:24136188 NCBI chr  X:101,163,075...101,171,276
Ensembl chr  X:101,163,053...101,171,275
JBrowse link
G Plin2 perilipin 2 affects binding ISO tolcapone binds to PLIN2 protein CTD PMID:19783845 NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297
JBrowse link
G Plin3 perilipin 3 affects binding ISO tolcapone binds to PLIN3 protein CTD PMID:19783845 NCBI chr17:56,585,962...56,597,511
Ensembl chr17:56,584,476...56,599,873
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression ISO tolcapone results in increased expression of PNPLA2 mRNA CTD PMID:24136188 NCBI chr 7:141,035,101...141,040,656
Ensembl chr 7:141,035,111...141,040,656
JBrowse link
G Polr1h RNA polymerase I subunit H decreases expression ISO Tolcapone results in decreased expression of POLR1H mRNA CTD PMID:24136188 NCBI chr17:37,265,250...37,269,417
Ensembl chr17:37,265,248...37,269,451
JBrowse link
G Polr2g polymerase (RNA) II (DNA directed) polypeptide G decreases expression ISO tolcapone results in decreased expression of POLR2G mRNA CTD PMID:24136188 NCBI chr19:8,770,493...8,775,921
Ensembl chr19:8,770,491...8,775,941
JBrowse link
G Prpf8 pre-mRNA processing factor 8 affects binding ISO tolcapone binds to PRPF8 protein CTD PMID:19783845 NCBI chr11:75,377,603...75,400,273
Ensembl chr11:75,377,642...75,400,275
JBrowse link
G Prxl2a peroxiredoxin like 2A affects binding ISO tolcapone binds to PRXL2A protein CTD PMID:19783845 NCBI chr14:40,715,692...40,735,790
Ensembl chr14:40,715,697...40,735,745
JBrowse link
G Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 affects binding ISO tolcapone binds to PSMC5 protein CTD PMID:19783845 NCBI chr11:106,147,011...106,153,938
Ensembl chr11:106,146,980...106,153,946
JBrowse link
G Psme2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) affects binding ISO tolcapone binds to PSME2 protein CTD PMID:19783845 NCBI chr14:55,824,897...55,828,558
Ensembl chr14:55,824,898...55,828,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Tolcapone results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ptrh2 peptidyl-tRNA hydrolase 2 affects binding ISO tolcapone binds to PTRH2 protein CTD PMID:19783845 NCBI chr11:86,574,900...86,583,283
Ensembl chr11:86,574,811...86,583,283
JBrowse link
G Ramac RNA guanine-7 methyltransferase activating subunit decreases expression ISO tolcapone results in decreased expression of RAMAC mRNA CTD PMID:24136188 NCBI chr 7:81,412,701...81,419,238
Ensembl chr 7:81,412,673...81,419,239
JBrowse link
G Ran RAN, member RAS oncogene family affects binding ISO tolcapone binds to RAN protein CTD PMID:19783845 NCBI chr 5:129,097,264...129,101,388
Ensembl chr 5:129,097,133...129,101,387
JBrowse link
G Rap1a RAS-related protein 1a decreases expression ISO tolcapone results in decreased expression of RAP1A mRNA CTD PMID:24136188 NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652
JBrowse link
G Rbis ribosomal biogenesis factor decreases expression ISO Tolcapone results in decreased expression of RBIS mRNA CTD PMID:24136188 NCBI chr 3:14,671,349...14,676,419
Ensembl chr 3:14,671,344...14,676,345
JBrowse link
G Rbm8a RNA binding motif protein 8a decreases expression ISO tolcapone results in decreased expression of RBM8A mRNA CTD PMID:24136188 NCBI chr 3:96,537,244...96,541,107
Ensembl chr 3:96,537,249...96,541,107
JBrowse link
G Rbp1 retinol binding protein 1, cellular decreases expression ISO tolcapone results in decreased expression of RBP1 mRNA CTD PMID:24136188 NCBI chr 9:98,305,014...98,328,604
Ensembl chr 9:98,305,014...98,328,628
JBrowse link
G Reep6 receptor accessory protein 6 affects binding ISO tolcapone binds to REEP6 protein CTD PMID:19783845 NCBI chr10:80,165,831...80,172,275
Ensembl chr10:80,165,787...80,172,275
JBrowse link
G Rnf7 ring finger protein 7 decreases expression ISO tolcapone results in decreased expression of RNF7 mRNA CTD PMID:24136188 NCBI chr 9:96,352,990...96,360,728
Ensembl chr 9:96,352,990...96,360,728
JBrowse link
G Rnls renalase, FAD-dependent amine oxidase decreases expression ISO tolcapone results in decreased expression of RNLS mRNA CTD PMID:24136188 NCBI chr19:33,115,140...33,369,695
Ensembl chr19:33,115,147...33,369,665
JBrowse link
G Romo1 reactive oxygen species modulator 1 decreases expression ISO tolcapone results in decreased expression of ROMO1 mRNA CTD PMID:24136188 NCBI chr 2:155,986,073...155,987,714
Ensembl chr 2:155,985,959...155,987,717
JBrowse link
G Rpa3 replication protein A3 decreases expression ISO tolcapone results in decreased expression of RPA3 mRNA CTD PMID:24136188 NCBI chr 6:8,255,936...8,259,141
Ensembl chr 6:8,255,936...8,259,173
JBrowse link
G Rpl10a ribosomal protein L10A affects binding ISO tolcapone binds to RPL10A protein CTD PMID:19783845 NCBI chr17:28,547,557...28,550,007
Ensembl chr17:28,547,445...28,550,007
JBrowse link
G Rpl15 ribosomal protein L15 affects binding ISO tolcapone binds to RPL15 protein CTD PMID:19783845 NCBI chr14:4,198,710...4,201,873
Ensembl chr14:4,198,305...4,201,873
JBrowse link
G Rpl18a ribosomal protein L18A affects binding ISO tolcapone binds to RPL18A protein CTD PMID:19783845 NCBI chr 8:71,347,366...71,350,087
Ensembl chr 8:71,347,366...71,350,056
JBrowse link
G Rpl22 ribosomal protein L22 affects binding ISO tolcapone binds to RPL22 protein CTD PMID:19783845 NCBI chr 4:152,408,893...152,418,539
Ensembl chr 4:152,410,199...152,418,528
JBrowse link
G Rpl22l1 ribosomal protein L22 like 1 decreases expression ISO tolcapone results in decreased expression of RPL22L1 mRNA CTD PMID:24136188 NCBI chr 3:28,859,660...28,861,573
Ensembl chr 3:28,859,585...28,861,573
JBrowse link
G Rpl23 ribosomal protein L23 affects binding ISO tolcapone binds to RPL23 protein CTD PMID:19783845 NCBI chr11:97,668,352...97,673,265
Ensembl chr11:97,668,353...97,673,263
JBrowse link
G Rpl35a ribosomal protein L35A decreases expression ISO tolcapone results in decreased expression of RPL35A mRNA CTD PMID:24136188 NCBI chr16:32,876,823...32,880,559
Ensembl chr16:32,876,823...32,880,559
JBrowse link
G Rpl36a ribosomal protein L36A decreases expression ISO tolcapone results in decreased expression of RPL36A mRNA CTD PMID:24136188 NCBI chr  X:133,486,403...133,488,811
Ensembl chr  X:133,486,403...133,488,811
JBrowse link
G Rpl41 ribosomal protein L41 decreases expression ISO tolcapone results in decreased expression of RPL41 mRNA CTD PMID:24136188 NCBI chr10:128,383,979...128,385,037
Ensembl chr10:128,383,983...128,385,174
JBrowse link
G Rpl7a ribosomal protein L7A affects binding ISO tolcapone binds to RPL7A protein CTD PMID:19783845 NCBI chr 2:26,800,697...26,803,330
Ensembl chr 2:26,800,776...26,803,330
JBrowse link
G Rpl7l1 ribosomal protein L7-like 1 affects binding ISO tolcapone binds to RPL7L1 protein CTD PMID:19783845 NCBI chr17:47,084,833...47,093,582
Ensembl chr17:47,084,833...47,093,598
JBrowse link
G Rpl9 ribosomal protein L9 decreases expression ISO tolcapone results in decreased expression of RPL9 mRNA CTD PMID:24136188 NCBI chr 5:65,545,707...65,548,774
Ensembl chr 5:65,545,707...65,548,787
JBrowse link
G Rpp21 ribonuclease P 21 subunit decreases expression ISO tolcapone results in decreased expression of RPP21 mRNA CTD PMID:24136188 NCBI chr17:36,566,565...36,568,738
Ensembl chr17:36,566,537...36,568,961
JBrowse link
G Rps11 ribosomal protein S11 affects binding ISO tolcapone binds to RPS11 protein CTD PMID:19783845 NCBI chr 7:44,771,812...44,773,813
Ensembl chr 7:44,771,803...44,773,863
JBrowse link
G Rps14 ribosomal protein S14 affects binding ISO tolcapone binds to RPS14 protein CTD PMID:19783845 NCBI chr18:60,907,668...60,911,618
Ensembl chr18:60,880,170...60,911,618
JBrowse link
G Rps15a ribosomal protein S15A decreases expression ISO tolcapone results in decreased expression of RPS15A mRNA CTD PMID:24136188 NCBI chr 7:117,703,597...117,715,370
Ensembl chr 7:117,703,595...117,715,411
JBrowse link
G Rps20 ribosomal protein S20 affects binding ISO tolcapone binds to RPS20 protein CTD PMID:19783845 NCBI chr 4:3,831,334...3,835,600
Ensembl chr 4:3,831,334...3,835,665
JBrowse link
G Rps21 ribosomal protein S21 decreases expression ISO tolcapone results in decreased expression of RPS21 mRNA CTD PMID:24136188 NCBI chr 2:179,899,172...179,900,237
Ensembl chr 2:179,899,170...179,900,238
JBrowse link
G Rps24 ribosomal protein S24 decreases expression ISO tolcapone results in decreased expression of RPS24 mRNA CTD PMID:24136188 NCBI chr14:24,540,786...24,545,925
Ensembl chr14:24,537,193...24,547,027
JBrowse link
G Rps25 ribosomal protein S25 decreases expression ISO tolcapone results in decreased expression of RPS25 mRNA CTD PMID:24136188 NCBI chr 9:44,319,011...44,321,703
Ensembl chr 9:44,318,436...44,321,724
JBrowse link
G Rps27 ribosomal protein S27 decreases expression ISO Tolcapone results in decreased expression of RPS27 mRNA CTD PMID:24136188 NCBI chr 3:90,119,974...90,120,955
Ensembl chr 3:90,119,829...90,120,958
JBrowse link
G Rps27a ribosomal protein S27A affects binding ISO tolcapone binds to RPS27A protein CTD PMID:19783845 NCBI chr11:29,495,842...29,498,040
Ensembl chr11:29,495,846...29,498,109
JBrowse link
G S100a10 S100 calcium binding protein A10 (calpactin) decreases expression ISO tolcapone results in decreased expression of S100A10 mRNA CTD PMID:24136188 NCBI chr 3:93,462,424...93,471,952
Ensembl chr 3:93,462,387...93,471,950
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO tolcapone results in increased expression of SC5D mRNA CTD PMID:24136188 NCBI chr 9:42,162,888...42,175,607
Ensembl chr 9:42,162,891...42,175,552
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 affects binding
decreases expression
ISO tolcapone binds to SCD protein
tolcapone results in decreased expression of SCD1 mRNA
CTD PMID:19783845 PMID:24136188 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
JBrowse link
G Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) affects binding ISO tolcapone binds to SDHA protein CTD PMID:19783845 NCBI chr13:74,470,374...74,498,359
Ensembl chr13:74,470,373...74,498,399
JBrowse link
G Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) affects binding ISO tolcapone binds to SDHB protein CTD PMID:19783845 NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504
JBrowse link
G Sec11c SEC11 homolog C, signal peptidase complex subunit affects binding ISO tolcapone binds to SEC11C protein CTD PMID:19783845 NCBI chr18:65,933,649...65,950,731
Ensembl chr18:65,933,586...65,950,755
JBrowse link
G Sec31a SEC31 homolog A, COPII coat complex component affects binding ISO tolcapone binds to SEC31A protein CTD PMID:19783845 NCBI chr 5:100,509,508...100,564,132
Ensembl chr 5:100,509,508...100,564,093
JBrowse link
G Serbp1 serpine1 mRNA binding protein 1 affects binding ISO tolcapone binds to SERBP1 protein CTD PMID:19783845 NCBI chr 6:67,243,963...67,266,286
Ensembl chr 6:67,215,160...67,274,720
JBrowse link
G Sf3b6 splicing factor 3B, subunit 6 affects binding ISO tolcapone binds to SF3B6 protein CTD PMID:19783845 NCBI chr12:4,867,608...4,877,659
Ensembl chr12:4,867,544...4,877,659
JBrowse link
G Sfxn1 sideroflexin 1 affects binding ISO tolcapone binds to SFXN1 protein CTD PMID:19783845 NCBI chr13:54,225,675...54,262,365
Ensembl chr13:54,225,888...54,262,361
JBrowse link
G Sik3 SIK family kinase 3 increases expression ISO tolcapone results in increased expression of SIK3 mRNA CTD PMID:24136188 NCBI chr 9:45,924,099...46,135,492
Ensembl chr 9:45,924,118...46,135,492
JBrowse link
G Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5 affects binding ISO tolcapone binds to SLC1A5 protein CTD PMID:19783845 NCBI chr 7:16,515,259...16,532,199
Ensembl chr 7:16,515,265...16,532,199
JBrowse link
G Slc25a1 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 affects binding ISO tolcapone binds to SLC25A1 protein CTD PMID:19783845 NCBI chr16:17,743,075...17,746,083
Ensembl chr16:17,743,087...17,746,083
JBrowse link
G Slc25a13 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 affects binding ISO tolcapone binds to SLC25A13 protein CTD PMID:19783845 NCBI chr 6:6,041,218...6,217,304
Ensembl chr 6:6,041,218...6,217,173
JBrowse link
G Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 affects binding ISO tolcapone binds to SLC25A4 protein CTD PMID:19783845 NCBI chr 8:46,660,205...46,664,099
Ensembl chr 8:46,659,834...46,664,321
JBrowse link
G Slc25a5 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 affects binding ISO tolcapone binds to SLC25A5 protein CTD PMID:19783845 NCBI chr  X:36,059,250...36,062,461
Ensembl chr  X:36,059,304...36,062,460
JBrowse link
G Slc39a7 solute carrier family 39 (zinc transporter), member 7 affects binding ISO tolcapone binds to SLC39A7 protein CTD PMID:19783845 NCBI chr17:34,247,240...34,250,664
Ensembl chr17:34,247,243...34,250,656
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 decreases expression ISO Tolcapone results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Tolcapone results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
JBrowse link
G Smim26 small integral membrane protein 26 decreases expression ISO tolcapone results in decreased expression of SMIM26 mRNA CTD PMID:24136188 NCBI chr 2:144,435,985...144,437,286
Ensembl chr 2:144,435,974...144,437,286
JBrowse link
G Snapin SNAP-associated protein decreases expression ISO tolcapone results in decreased expression of SNAPIN mRNA CTD PMID:24136188 NCBI chr 3:90,395,333...90,398,320
Ensembl chr 3:90,395,333...90,398,340
JBrowse link
G Snca synuclein, alpha multiple interactions ISO tolcapone inhibits the reaction [SNCA protein binds to SNCA protein] CTD PMID:20150427 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Snrnp27 small nuclear ribonucleoprotein 27 (U4/U6.U5) decreases expression ISO Tolcapone results in decreased expression of SNRNP27 mRNA CTD PMID:24136188 NCBI chr 6:86,652,151...86,661,473
Ensembl chr 6:86,652,133...86,661,504
JBrowse link
G Snrpb2 U2 small nuclear ribonucleoprotein B decreases expression ISO tolcapone results in decreased expression of SNRPB2 mRNA CTD PMID:24136188 NCBI chr 2:142,904,989...142,913,972
Ensembl chr 2:142,904,959...142,914,773
JBrowse link
G Snrpd3 small nuclear ribonucleoprotein D3 decreases expression ISO tolcapone results in decreased expression of SNRPD3 mRNA CTD PMID:24136188 NCBI chr10:75,353,852...75,371,300
Ensembl chr10:75,353,385...75,373,215
JBrowse link
G Snrpe small nuclear ribonucleoprotein E decreases expression ISO tolcapone results in decreased expression of SNRPE mRNA CTD PMID:24136188 NCBI chr 1:133,531,609...133,538,018
Ensembl chr 1:133,531,609...133,538,029
JBrowse link
G Snrpf small nuclear ribonucleoprotein polypeptide F decreases expression ISO tolcapone results in decreased expression of SNRPF mRNA CTD PMID:24136188 NCBI chr10:93,418,891...93,425,520
Ensembl chr10:93,418,891...93,425,568
JBrowse link
G Snrpg small nuclear ribonucleoprotein polypeptide G decreases expression ISO tolcapone results in decreased expression of SNRPG mRNA CTD PMID:24136188 NCBI chr 6:86,348,522...86,355,884
Ensembl chr 6:86,348,286...86,356,310
JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases expression ISO tolcapone results in decreased expression of SOD1 mRNA CTD PMID:28526448 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases expression ISO tolcapone results in decreased expression of SOD2 mRNA CTD PMID:28526448 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Srp14 signal recognition particle 14 decreases expression ISO tolcapone results in decreased expression of SRP14 mRNA CTD PMID:24136188 NCBI chr 2:118,306,324...118,310,177
Ensembl chr 2:118,306,331...118,310,192
JBrowse link
G Srprb signal recognition particle receptor, B subunit affects binding ISO tolcapone binds to SRPRB protein CTD PMID:19783845 NCBI chr 9:103,065,232...103,079,264
Ensembl chr 9:103,065,231...103,079,336
JBrowse link
G Ss18l2 SS18, nBAF chromatin remodeling complex subunit like 2 decreases expression ISO tolcapone results in decreased expression of SS18L2 mRNA CTD PMID:24136188 NCBI chr 9:121,539,455...121,541,987
Ensembl chr 9:121,539,395...121,542,454
JBrowse link
G Ssr1 signal sequence receptor, alpha affects binding ISO tolcapone binds to SSR1 protein CTD PMID:19783845 NCBI chr13:38,155,377...38,178,184
Ensembl chr13:38,150,581...38,178,193
JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression ISO tolcapone results in decreased expression of STAC3 mRNA CTD PMID:24136188 NCBI chr10:127,337,505...127,344,692
Ensembl chr10:127,337,555...127,344,692
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO tolcapone results in increased expression of STAT3 mRNA CTD PMID:24136188 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 affects binding ISO tolcapone binds to SULT2A1 protein CTD PMID:19783845 NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334
JBrowse link
G Taf9 TATA-box binding protein associated factor 9 decreases expression ISO tolcapone results in decreased expression of TAF9 mRNA CTD PMID:24136188 NCBI chr13:100,787,851...100,792,568
Ensembl chr13:100,788,087...100,792,568
Ensembl chr13:100,788,087...100,792,568
JBrowse link
G Tbca tubulin cofactor A decreases expression ISO tolcapone results in decreased expression of TBCA mRNA CTD PMID:24136188 NCBI chr13:94,925,428...94,979,431
Ensembl chr13:94,925,418...94,979,430
JBrowse link
G Tceal8 transcription elongation factor A (SII)-like 8 decreases expression ISO tolcapone results in decreased expression of TCEAL8 mRNA CTD PMID:24136188 NCBI chr  X:135,069,733...135,073,000
Ensembl chr  X:135,069,733...135,073,091
JBrowse link
G Tfr2 transferrin receptor 2 increases expression ISO tolcapone results in increased expression of TFR2 mRNA CTD PMID:24136188 NCBI chr 5:137,568,127...137,586,344
Ensembl chr 5:137,568,102...137,585,743
JBrowse link
G Timm10 translocase of inner mitochondrial membrane 10 decreases expression ISO tolcapone results in decreased expression of TIMM10 mRNA CTD PMID:24136188 NCBI chr 2:84,657,365...84,660,557
Ensembl chr 2:84,657,341...84,660,557
JBrowse link
G Timm44 translocase of inner mitochondrial membrane 44 affects binding ISO tolcapone binds to TIMM44 protein CTD PMID:19783845 NCBI chr 8:4,309,731...4,325,905
Ensembl chr 8:4,309,731...4,325,913
JBrowse link
G Timm8b translocase of inner mitochondrial membrane 8B decreases expression ISO tolcapone results in decreased expression of TIMM8B mRNA CTD PMID:24136188 NCBI chr 9:50,515,227...50,516,620
Ensembl chr 9:50,515,210...50,516,620
JBrowse link
G Tk2 thymidine kinase 2, mitochondrial affects binding ISO tolcapone binds to TK2 protein CTD PMID:19783845 NCBI chr 8:104,953,323...104,975,224
Ensembl chr 8:104,953,317...104,975,190
JBrowse link
G Tm2d1 TM2 domain containing 1 decreases expression ISO tolcapone results in decreased expression of TM2D1 mRNA CTD PMID:24136188 NCBI chr 4:98,243,607...98,271,523
Ensembl chr 4:98,243,607...98,271,543
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 affects binding ISO tolcapone binds to TMED10 protein CTD PMID:19783845 NCBI chr12:85,387,388...85,421,491
Ensembl chr12:85,387,388...85,421,621
JBrowse link
G Tmed4 transmembrane p24 trafficking protein 4 affects binding ISO tolcapone binds to TMED4 protein CTD PMID:19783845 NCBI chr11:6,220,714...6,224,837
Ensembl chr11:6,220,369...6,224,870
JBrowse link
G Tmed9 transmembrane p24 trafficking protein 9 affects binding ISO tolcapone binds to TMED9 protein CTD PMID:19783845 NCBI chr13:55,740,948...55,745,510
Ensembl chr13:55,721,545...55,745,510
JBrowse link
G Tmem126a transmembrane protein 126A decreases expression ISO tolcapone results in decreased expression of TMEM126A mRNA CTD PMID:24136188 NCBI chr 7:90,099,908...90,106,411
Ensembl chr 7:90,099,908...90,106,437
JBrowse link
G Tmem126b transmembrane protein 126B decreases expression ISO tolcapone results in decreased expression of TMEM126B mRNA CTD PMID:24136188 NCBI chr 7:90,118,041...90,125,203
Ensembl chr 7:90,116,646...90,125,209
JBrowse link
G Tmem128 transmembrane protein 128 decreases expression ISO tolcapone results in decreased expression of TMEM128 mRNA CTD PMID:24136188 NCBI chr 5:38,417,529...38,426,978
Ensembl chr 5:38,417,529...38,426,978
JBrowse link
G Tmem203 transmembrane protein 203 decreases expression ISO tolcapone results in decreased expression of TMEM203 mRNA CTD PMID:24136188 NCBI chr 2:25,145,451...25,146,364
Ensembl chr 2:25,145,451...25,146,304
JBrowse link
G Tmem238 transmembrane protein 238 decreases expression ISO tolcapone results in decreased expression of TMEM238 mRNA CTD PMID:24136188 NCBI chr 7:4,787,784...4,792,559
Ensembl chr 7:4,787,556...4,792,655
JBrowse link
G Tmem256 transmembrane protein 256 decreases expression ISO tolcapone results in decreased expression of TMEM256 mRNA CTD PMID:24136188 NCBI chr11:69,729,375...69,730,813
Ensembl chr11:69,729,340...69,730,444
JBrowse link
G Tmsb4x thymosin, beta 4, X chromosome decreases expression ISO tolcapone results in decreased expression of TMSB4X mRNA CTD PMID:24136188 NCBI chr  X:165,990,089...165,996,475
Ensembl chr  X:165,990,089...165,992,311
JBrowse link
G Tnfaip8 tumor necrosis factor, alpha-induced protein 8 affects binding ISO tolcapone binds to TNFAIP8 protein CTD PMID:19783845 NCBI chr18:50,112,494...50,226,296
Ensembl chr18:50,112,494...50,240,240
JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a increases expression ISO tolcapone results in increased expression of TNFRSF1A mRNA CTD PMID:24136188 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 affects binding ISO tolcapone binds to TOMM20 protein CTD PMID:19783845 NCBI chr 8:127,657,414...127,672,671
Ensembl chr 8:127,657,417...127,672,594
JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 affects binding ISO tolcapone binds to TOMM40 protein CTD PMID:19783845 NCBI chr 7:19,435,238...19,449,370
Ensembl chr 7:19,435,238...19,449,363
JBrowse link
G Tomm7 translocase of outer mitochondrial membrane 7 affects binding ISO tolcapone binds to TOMM7 protein CTD PMID:19783845 NCBI chr 5:24,043,942...24,049,143
Ensembl chr 5:24,043,942...24,049,159
JBrowse link
G Trappc2l trafficking protein particle complex 2L decreases expression ISO tolcapone results in decreased expression of TRAPPC2L mRNA CTD PMID:24136188 NCBI chr 8:123,338,365...123,342,330
Ensembl chr 8:123,338,379...123,343,399
JBrowse link
G Tspan6 tetraspanin 6 decreases expression ISO tolcapone results in decreased expression of TSPAN6 mRNA CTD PMID:24136188 NCBI chr  X:132,791,817...132,801,957
Ensembl chr  X:132,791,817...132,799,178
JBrowse link
G Tubb6 tubulin, beta 6 class V affects binding ISO tolcapone binds to TUBB6 protein CTD PMID:19783845 NCBI chr18:67,523,801...67,535,819
Ensembl chr18:67,523,787...67,535,819
JBrowse link
G Txndc17 thioredoxin domain containing 17 decreases expression ISO tolcapone results in decreased expression of TXNDC17 mRNA CTD PMID:24136188 NCBI chr11:72,098,380...72,101,313
Ensembl chr11:72,098,373...72,100,841
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 decreases glucuronidation
increases glucuronidation
ISO UGT1A9 protein mutant form results in decreased glucuronidation of tolcapone
UGT1A9 protein results in increased glucuronidation of tolcapone
CTD PMID:16344532 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 affects binding ISO tolcapone binds to UQCRC2 protein CTD PMID:19783845 NCBI chr 7:120,234,412...120,258,746
Ensembl chr 7:120,234,399...120,258,747
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 affects binding ISO tolcapone binds to UQCRFS1 protein CTD PMID:19783845 NCBI chr13:30,724,295...30,729,299
Ensembl chr13:30,724,291...30,729,345
JBrowse link
G Uvrag UV radiation resistance associated gene increases expression ISO tolcapone results in increased expression of UVRAG mRNA CTD PMID:24136188 NCBI chr 7:98,535,949...98,790,373
Ensembl chr 7:98,534,228...98,790,348
JBrowse link
G Vdac2 voltage-dependent anion channel 2 affects binding ISO tolcapone binds to VDAC2 protein CTD PMID:19783845 NCBI chr14:21,881,629...21,895,947
Ensembl chr14:21,875,306...21,895,947
JBrowse link
G Vdac3 voltage-dependent anion channel 3 affects binding ISO tolcapone binds to VDAC3 protein CTD PMID:19783845 NCBI chr 8:23,067,091...23,083,829
Ensembl chr 8:23,067,102...23,083,774
JBrowse link
G Vsnl1 visinin-like 1 affects binding ISO tolcapone binds to VSNL1 protein CTD PMID:19783845 NCBI chr12:11,375,258...11,486,579
Ensembl chr12:11,375,243...11,486,614
JBrowse link
G Washc3 WASH complex subunit 3 decreases expression ISO tolcapone results in decreased expression of WASHC3 mRNA CTD PMID:24136188 NCBI chr10:88,036,954...88,160,001
Ensembl chr10:88,036,955...88,082,020
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein affects binding ISO tolcapone binds to WFS1 protein CTD PMID:19783845 NCBI chr 5:37,123,448...37,146,326
Ensembl chr 5:37,123,448...37,146,549
JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 increases expression ISO Tolcapone results in increased expression of YARS1 mRNA CTD PMID:24136188 NCBI chr 4:129,083,595...129,113,033
Ensembl chr 4:129,083,553...129,113,400
JBrowse link
G Yeats4 YEATS domain containing 4 decreases expression ISO tolcapone results in decreased expression of YEATS4 mRNA CTD PMID:24136188 NCBI chr10:117,051,046...117,060,412
Ensembl chr10:117,051,126...117,060,412
JBrowse link
G Znrf1 zinc and ring finger 1 increases expression ISO tolcapone results in increased expression of ZNRF1 mRNA CTD PMID:24136188 NCBI chr 8:112,262,652...112,352,352
Ensembl chr 8:112,262,729...112,352,662
JBrowse link
trifluridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO CA 074 methyl ester inhibits the reaction [Trifluridine results in increased cleavage of CASP3 protein]; Trifluridine results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:19816940 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 increases cleavage ISO Trifluridine results in increased cleavage of CASP8 protein CTD PMID:19816940 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Trifluridine results in increased cleavage of CASP9 protein CTD PMID:19816940 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Ctsb cathepsin B increases cleavage
multiple interactions
ISO Trifluridine results in increased cleavage of CTSB protein
CA 074 methyl ester inhibits the reaction [Trifluridine results in increased cleavage of CTSB protein]
CTD PMID:19816940 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO Trifluridine inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Trifluridine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr19:6,888,345...6,899,182
Ensembl chr19:6,888,345...6,899,208
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases activity ISO Trifluridine results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Trifluridine results in increased activity of NR1I2 protein
[Trifluridine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Trifluridine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] CTD PMID:30818834 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO Trifluridine results in increased cleavage of PARP1 protein CTD PMID:19816940 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Trp53 transformation related protein 53 affects activity ISO Trifluridine affects the activity of TP53 protein CTD PMID:35435491 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22340
    role 22326
      biological role 22325
        biochemical role 21550
          enzyme inhibitor 19938
            EC 2.* (transferase) inhibitor 15352
              EC 2.1.* (C1-transferase) inhibitor 3783
                EC 2.1.1.* (methyltransferases) inhibitor 706
                  BIX-01294 trihydrochloride 0
                  EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor + 271
                  EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor + 302
                  EC 2.1.1.348 (mRNA m6A methyltransferase) inhibitor + 0
                  EC 2.1.1.354 ([histone H3]-lysine(4) N-trimethyltransferase) inhibitor + 8
                  EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitor + 0
                  EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitor + 0
                  EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor + 2
                  EC 2.1.1.45 (thymidylate synthase) inhibitor + 48
                  EC 2.1.1.6 (catechol O-methyltransferase) inhibitor + 352
                  EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor + 28
                  EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor + 28
                  EC 2.1.1.8 (histamine N-methyltransferase) inhibitor + 46
                  sterol methyltransferase inhibitor + 0
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