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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.1.1.* (methyltransferases) inhibitor
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Accession:CHEBI:76871 term browser browse the term
Definition:An EC 2.1.* (C1-transferase) inhibitor that interferes with the action of any methyltransferase (EC 2.1.1.*).
Synonyms:related_synonym: EC 2.1.1.* (methyltransferases) inhibitors;   EC 2.1.1.* inhibitor;   EC 2.1.1.* inhibitors;   methyltransferase (EC 2.1.1.*) inhibitor;   methyltransferase (EC 2.1.1.*) inhibitors



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amodiaquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) multiple interactions EXP Amodiaquine analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein] CTD PMID:29614332 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein
Amodiaquine results in increased expression of BAX protein
CTD PMID:31629065 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCHE butyrylcholinesterase multiple interactions EXP Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein] CTD PMID:29614332 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP Amodiaquine results in decreased expression of BCL2 protein
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein
CTD PMID:31629065 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BMP6 bone morphogenetic protein 6 increases expression EXP Amodiaquine results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728
JBrowse link
G CASP3 caspase 3 increases cleavage EXP Amodiaquine results in increased cleavage of CASP3 protein CTD PMID:31629065 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CCND1 cyclin D1 affects expression EXP Amodiaquine affects the expression of CCND1 protein CTD PMID:24113242 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A affects expression EXP Amodiaquine affects the expression of CDKN1A mRNA; Amodiaquine affects the expression of CDKN1A protein CTD PMID:24113242 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397
JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 multiple interactions ISO CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]] CTD PMID:29938495 NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965
JBrowse link
G CTSB cathepsin B decreases activity EXP Amodiaquine results in decreased activity of CTSB protein CTD PMID:24113242 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533
JBrowse link
G CTSD cathepsin D decreases activity EXP Amodiaquine results in decreased activity of CTSD protein CTD PMID:24113242 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
JBrowse link
G CTSL cathepsin L decreases activity EXP Amodiaquine results in decreased activity of CTSL protein CTD PMID:24113242 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases activity
increases metabolic processing
multiple interactions
decreases response to substance
EXP Amodiaquine results in increased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of Amodiaquine
[CYP1A1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CYP1A1 protein results in decreased susceptibility to Amodiaquine
CTD PMID:12451431 PMID:31629065 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity
increases metabolic processing
multiple interactions
EXP Amodiaquine results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased metabolism of Amodiaquine
[CYP1A2 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [Gemfibrozil results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine; [Trimethoprim results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine
CTD PMID:11124226 PMID:26599973 PMID:31629065 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases response to substance
multiple interactions
increases metabolic processing
EXP CYP1B1 protein results in decreased susceptibility to Amodiaquine
[CYP1B1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:31629065 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A member 13 multiple interactions
increases metabolic processing
EXP [CYP2A13 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine CTD PMID:31629065 NCBI chr19:41,088,451...41,096,195
Ensembl chr19:41,088,451...41,096,195
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases metabolic processing
multiple interactions
EXP CYP2A6 protein results in increased metabolism of Amodiaquine
[CYP2A6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:31629065 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases metabolic processing
multiple interactions
EXP CYP2B6 protein results in increased metabolism of Amodiaquine
[CYP2B6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:31629065 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 multiple interactions
increases metabolic processing
EXP [CYP2C18 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine CTD PMID:31629065 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity
multiple interactions
increases metabolic processing
EXP Amodiaquine results in decreased activity of CYP2C19 protein
[CYP2C19 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:11124226 PMID:31629065 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 multiple interactions
increases response to substance
increases metabolic processing
affects metabolic processing
EXP [5-bromotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [5-chlorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [5-fluorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased abundance of and results in increased secretion of desethylamodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of desethylamodiaquine; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Tryptamines analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; Felodipine inhibits the reaction [CYP2C8 protein results in increased metabolism of Amodiaquine]; Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]
CYP2C8 protein affects the metabolism of Amodiaquine
CTD PMID:12920490 PMID:15155557 PMID:15601807 PMID:15626586 PMID:15771232 More... NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP Amodiaquine results in decreased activity of CYP2C9 protein CTD PMID:11124226 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) multiple interactions
increases metabolic processing
EXP [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine CTD PMID:28478157 PMID:31629065 PMID:33259822 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
increases metabolic processing
EXP [CYP2E1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine CTD PMID:31629065 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases metabolic processing
increases response to substance
multiple interactions
EXP CYP3A4 protein results in increased metabolism of Amodiaquine
CYP3A4 protein results in increased susceptibility to Amodiaquine
[CYP3A4 protein results in increased metabolism of Amodiaquine] which results in increased abundance of and results in increased secretion of desethylamodiaquine; [CYP3A4 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]
CTD PMID:28478157 PMID:31629065 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 multiple interactions
increases metabolic processing
EXP [CYP3A5 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine CTD PMID:31629065 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996
JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 increases metabolic processing
multiple interactions
EXP CYP3A7 protein results in increased metabolism of Amodiaquine
[CYP3A7 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:31629065 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196
JBrowse link
G E2F1 E2F transcription factor 1 affects expression EXP Amodiaquine affects the expression of E2F1 mRNA; Amodiaquine affects the expression of E2F1 protein CTD PMID:24113242 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G EREG epiregulin increases expression EXP Amodiaquine results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO [LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]] CTD PMID:29938495 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G IL1A interleukin 1 alpha decreases expression EXP Amodiaquine results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G LAG3 lymphocyte activating 3 multiple interactions ISO [PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein] CTD PMID:29938495 NCBI chr12:6,772,520...6,778,455
Ensembl chr12:6,772,512...6,778,455
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein CTD PMID:31629065 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein CTD PMID:31629065 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein CTD PMID:31629065 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions
EXP Amodiaquine results in decreased expression of MCL1 protein
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein
CTD PMID:31629065 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase increases expression EXP Amodiaquine results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377
JBrowse link
G MPO myeloperoxidase affects response to substance ISO MPO protein affects the susceptibility to Amodiaquine CTD PMID:24588327 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions EXP Amodiaquine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3] CTD PMID:29281794 NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,019,755
JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 multiple interactions EXP Amodiaquine binds to and results in increased activity of NR4A2 protein CTD PMID:31175960 NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348
JBrowse link
G PDCD1 programmed cell death 1 multiple interactions ISO [PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]] CTD PMID:29938495 NCBI chr 2:241,849,884...241,858,894
Ensembl chr 2:241,849,884...241,858,894
JBrowse link
G PID1 phosphotyrosine interaction domain containing 1 increases expression EXP Amodiaquine results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 2:229,023,973...229,271,287
Ensembl chr 2:228,850,526...229,271,287
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Amodiaquine results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RB1 RB transcriptional corepressor 1 affects phosphorylation EXP Amodiaquine affects the phosphorylation of RB1 protein CTD PMID:24113242 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]] CTD PMID:29938495 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 decreases expression EXP Amodiaquine results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 2:151,357,592...151,381,340
Ensembl chr 2:151,357,592...151,380,046
JBrowse link
G TP53 tumor protein p53 increases activity
affects expression
EXP Amodiaquine results in increased activity of TP53 protein
Amodiaquine affects the expression of TP53 protein
CTD PMID:12082016 PMID:24113242 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
berberine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression EXP berberine increases expression of abca1 protein in mouse liver and human hepatocytes RGD PMID:29505790 RGD:19165131 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 increases expression ISO Berberine results in increased expression of ABCB1A mRNA CTD PMID:20410605 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of ACADM mRNA] CTD PMID:25455889 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,431...75,787,575
JBrowse link
G ACAN aggrecan decreases expression EXP Berberine results in decreased expression of ACAN mRNA CTD PMID:26478571 NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,353
JBrowse link
G ACHE acetylcholinesterase (Yt blood group) multiple interactions
decreases activity
ISO
EXP
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA]; Berberine inhibits the reaction [acetamiprid results in increased activity of ACHE protein]
Berberine results in decreased activity of ACHE protein
CTD PMID:29170048 PMID:33844597 PMID:37350525 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACOX1 acyl-CoA oxidase 1 multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:25455889 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G ACTA2 actin alpha 2, smooth muscle decreases expression
multiple interactions
ISO Berberine results in decreased expression of ACTA2 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of ACTA2 mRNA]
CTD PMID:17973934 PMID:37839514 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AGER advanced glycosylation end-product specific receptor multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of AGER mRNA] CTD PMID:35121005 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G AHR aryl hydrocarbon receptor increases activity ISO
EXP
Berberine results in increased activity of AHR protein CTD PMID:16046213 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]
Berberine results in decreased phosphorylation of AKT1 protein
Berberine inhibits the reaction [Thioacetamide results in increased phosphorylation of AKT1 protein]
Berberine results in increased phosphorylation of AKT1 protein
CTD PMID:23954465 PMID:30138605 PMID:33325633 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
JBrowse link
G AKT2 AKT serine/threonine kinase 2 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in decreased expression of AKT2 mRNA] CTD PMID:20462044 NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536
JBrowse link
G ALB albumin multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in decreased expression of ALB protein] CTD PMID:30138605 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] CTD PMID:29170048 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
JBrowse link
G AURKB aurora kinase B decreases expression EXP Berberine results in decreased expression of AURKB mRNA CTD PMID:27311644 NCBI chr17:8,204,731...8,210,575
Ensembl chr17:8,204,733...8,210,600
JBrowse link
G AURKC aurora kinase C increases expression EXP Berberine results in increased expression of AURKC mRNA CTD PMID:27311644 NCBI chr19:57,231,023...57,235,548
Ensembl chr19:57,231,009...57,235,548
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
[Berberine co-treated with Thioacetamide] results in increased expression of BAX mRNA; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of BAX mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein]
Berberine results in increased expression of BAX mRNA; Berberine results in increased expression of BAX protein
[Berberine co-treated with Cisplatin] results in increased expression of BAX protein; [Berberine co-treated with Niacinamide] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased expression of BAX protein]; SRT1720 inhibits the reaction [Berberine results in increased expression of BAX protein]
CTD PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 More... NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 increases expression
multiple interactions
EXP Berberine results in increased expression of BBC3 mRNA
[Berberine co-treated with Niacinamide] results in increased expression of BBC3 mRNA
CTD PMID:26712469 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
increases expression
multiple interactions
EXP
ISO
Berberine results in decreased expression of BCL2 mRNA; Berberine results in decreased expression of BCL2 protein
Berberine results in increased expression of BCL2 protein
Berberine inhibits the reaction [Chlorpyrifos results in decreased expression of BCL2 mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of BCL2 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]
[Berberine co-treated with Cisplatin] results in decreased expression of BCL2 protein; [Berberine co-treated with Niacinamide] results in decreased expression of BCL2 protein; Berberine inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
CTD PMID:16505103 PMID:20656010 PMID:23954465 PMID:24751971 PMID:25600690 More... NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP Berberine results in decreased expression of BCL2L1 protein CTD PMID:16505103 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCL2L11 BCL2 like 11 multiple interactions
increases expression
EXP [Berberine co-treated with Niacinamide] results in increased expression of BCL2L11 mRNA
Berberine results in increased expression of BCL2L11 mRNA
CTD PMID:26712469 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444
JBrowse link
G BECN1 beclin 1 multiple interactions ISO Berberine inhibits the reaction [Chlorpyrifos results in decreased expression of BECN1 mRNA]
Berberine promotes the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BECN1 protein]
CTD PMID:35439518 PMID:38705399 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein increases expression
multiple interactions
EXP Berberine results in increased expression of BGLAP mRNA; Berberine results in increased expression of BGLAP protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]
CTD PMID:26478571 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 affects binding EXP Berberine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G BNIP3 BCL2 interacting protein 3 multiple interactions
increases expression
EXP
ISO
[Cisplatin co-treated with Berberine] results in increased expression of BNIP3 protein
Berberine promotes the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BNIP3 protein]
Berberine results in increased expression of BNIP3 protein
CTD PMID:36070022 PMID:38705399 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967
JBrowse link
G BNIP3L BCL2 interacting protein 3 like multiple interactions
increases expression
EXP [Cisplatin co-treated with Berberine] results in increased expression of BNIP3L protein; BNIP3L protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]
Berberine results in increased expression of BNIP3L protein
CTD PMID:36070022 NCBI chr 8:26,383,054...26,413,127
Ensembl chr 8:26,383,054...26,505,636
JBrowse link
G CASP1 caspase 1 multiple interactions ISO Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of and results in increased cleavage of CASP1 protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CASP1 mRNA] CTD PMID:38705399 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
increases cleavage
increases expression
EXP
ISO
[Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; [Berberine co-treated with Niacinamide] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein]; Berberine results in increased cleavage of and results in increased activity of CASP3 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of CASP3 protein]
Berberine increases activity of CASP3 protein in colon epithelial cells
Berberine results in increased cleavage of CASP3 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP3 mRNA; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 mRNA]; Berberine inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of CASP3 mRNA]
Berberine results in increased activity of CASP3 protein
Berberine results in increased expression of CASP3 mRNA
CTD
RGD
PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 More... RGD:152995489 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP8 caspase 8 increases activity EXP Berberine results in increased activity of CASP8 protein CTD PMID:20656010 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G CASP9 caspase 9 increases cleavage
multiple interactions
EXP
ISO
Berberine results in increased cleavage of CASP9 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of CASP9 protein]
[Berberine co-treated with Thioacetamide] results in increased expression of CASP9 mRNA
[Berberine co-treated with Niacinamide] results in increased cleavage of CASP9 protein
CTD PMID:16505103 PMID:26712469 PMID:30138605 PMID:37839514 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the activity of CAT protein]; Berberine inhibits the reaction [acetamiprid results in decreased activity of CAT protein]; Berberine inhibits the reaction [Bortezomib results in decreased expression of CAT protein]; Berberine inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Berberine inhibits the reaction [Thioacetamide results in decreased activity of CAT protein]
Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of CAT protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of CAT protein]
CTD PMID:20828602 PMID:24751971 PMID:25600690 PMID:30138605 PMID:33460233 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP
ISO
Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]
Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CCL2 protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CCL2 mRNA]
CTD PMID:16391493 PMID:35691465 PMID:38705399 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
JBrowse link
G CCND1 cyclin D1 decreases expression
multiple interactions
EXP Berberine results in decreased expression of CCND1 protein
Berberine inhibits the reaction [CDK4 mRNA binds to CCND1 mRNA]
CTD PMID:16505103 PMID:33325633 PMID:36822301 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND2 cyclin D2 decreases expression EXP Berberine results in decreased expression of CCND2 protein CTD PMID:16505103 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP Berberine results in decreased expression of CCNE1 protein CTD PMID:16505103 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCNT1 cyclin T1 multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein] CTD PMID:20828602 NCBI chr12:48,688,458...48,716,707
Ensembl chr12:48,688,458...48,716,998
JBrowse link
G CD36 CD36 molecule (CD36 blood group) multiple interactions
increases expression
EXP
ISO
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of CD36 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased expression of CD36 protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; Berberine results in increased expression of and affects the localization of CD36 protein; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
Berberine results in increased expression of CD36 mRNA; Berberine results in increased expression of CD36 protein
CTD PMID:28038998 PMID:29408570 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CDH1 cadherin 1 multiple interactions ISO Berberine inhibits the reaction [Particulate Matter results in decreased expression of CDH1 mRNA] CTD PMID:37839514 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
JBrowse link
G CDH2 cadherin 2 decreases expression EXP Berberine results in decreased expression of CDH2 mRNA CTD PMID:26478571 NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP Berberine results in decreased expression of CDK2 protein CTD PMID:16505103 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression
multiple interactions
EXP Berberine results in decreased expression of CDK4 protein
Berberine inhibits the reaction [CDK4 mRNA binds to CCND1 mRNA]
CTD PMID:16505103 PMID:36822301 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDK6 cyclin dependent kinase 6 decreases expression EXP Berberine results in decreased expression of CDK6 protein CTD PMID:16505103 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573
JBrowse link
G CDK9 cyclin dependent kinase 9 multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein] CTD PMID:20828602 NCBI chr 9:127,786,034...127,790,792
Ensembl chr 9:127,785,679...127,790,792
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP Berberine results in increased expression of CDKN1A protein CTD PMID:16505103 PMID:23747414 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP Berberine results in increased expression of CDKN1B protein CTD PMID:16505103 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
JBrowse link
G CDKN1C cyclin dependent kinase inhibitor 1C increases expression EXP Berberine results in increased expression of CDKN1C mRNA CTD PMID:26478571 NCBI chr11:2,883,218...2,885,775
Ensembl chr11:2,883,213...2,885,775
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions
decreases expression
ISO
EXP
Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Berberine results in decreased expression of CEBPA mRNA; Berberine results in decreased expression of CEBPA protein
CTD PMID:20564506 PMID:26478571 PMID:37511356 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CEBPB CCAAT enhancer binding protein beta increases expression
affects phosphorylation
multiple interactions
EXP
ISO
Berberine results in increased expression of CEBPB mRNA
Berberine affects the phosphorylation of CEBPB protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased phosphorylation of CEBPB protein]; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
CTD PMID:28038998 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,734...50,192,690
JBrowse link
G CHEK1 checkpoint kinase 1 increases expression EXP Berberine results in increased expression of CHEK1 protein modified form CTD PMID:23747414 NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255
JBrowse link
G CHEK2 checkpoint kinase 2 increases expression EXP Berberine results in increased expression of CHEK2 protein modified form CTD PMID:23747414 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G COL10A1 collagen type X alpha 1 chain increases expression EXP Berberine results in increased expression of COL10A1 mRNA CTD PMID:26478571 NCBI chr 6:116,118,909...116,217,144
Ensembl chr 6:116,118,909...116,158,747
JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression
multiple interactions
EXP
ISO
Berberine results in increased expression of COL1A1 mRNA
Berberine inhibits the reaction [Particulate Matter results in increased expression of COL1A1 mRNA]
CTD PMID:26478571 PMID:37839514 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL2A1 collagen type II alpha 1 chain decreases expression EXP Berberine results in decreased expression of COL2A1 mRNA CTD PMID:26478571 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G COL3A1 collagen type III alpha 1 chain multiple interactions ISO Berberine inhibits the reaction [Particulate Matter results in increased expression of COL3A1 mRNA] CTD PMID:37839514 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
JBrowse link
G COX4I1 cytochrome c oxidase subunit 4I1 multiple interactions ISO Berberine inhibits the reaction [acetamiprid results in decreased expression of COX4I1 mRNA] CTD PMID:37350525 NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:25455889 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in decreased expression of CREB1 protein] CTD PMID:35121005 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CREBBP CREB binding protein increases expression EXP Berberine results in increased expression of CREBBP mRNA CTD PMID:27311644 NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713
JBrowse link
G CST3 cystatin C multiple interactions ISO Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CST3 protein] CTD PMID:38705399 NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473
JBrowse link
G CTNNB1 catenin beta 1 increases expression
multiple interactions
EXP Berberine results in increased expression of CTNNB1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]
CTD PMID:26478571 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CTSD cathepsin D multiple interactions
decreases cleavage
EXP GSK2795039 affects the reaction [Berberine results in decreased cleavage of CTSD protein] CTD PMID:36070022 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
JBrowse link
G CTSL cathepsin L multiple interactions
decreases cleavage
EXP Acetylcysteine inhibits the reaction [Berberine results in decreased cleavage of CTSL protein]; GSK2795039 affects the reaction [Berberine results in decreased cleavage of CTSL protein] CTD PMID:36070022 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [Mustard Gas results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein] CTD PMID:16391493 PMID:28916288 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions EXP Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to NCF1 protein]; Berberine promotes the reaction [CYBB protein binds to NCF2 protein]; Berberine promotes the reaction [CYBB protein binds to RAC2 protein] CTD PMID:36070022 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461
JBrowse link
G CYCS cytochrome c, somatic affects localization
multiple interactions
EXP Berberine affects the localization of CYCS protein
[Berberine co-treated with Cisplatin] results in increased expression of CYCS protein
CTD PMID:16505103 PMID:36070022 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP17A1 mRNA] CTD PMID:20462044 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity
increases expression
multiple interactions
EXP
ISO
Berberine results in decreased activity of CYP1A1 protein
Berberine results in increased expression of CYP1A1 mRNA
Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
CTD PMID:16046213 PMID:22342832 PMID:24583342 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA] CTD PMID:22342832 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions
increases expression
ISO Berberine inhibits the reaction [Streptozocin results in increased expression of CYP2B10 mRNA]; Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]
Berberine results in increased expression of CYP2B10 mRNA
CTD PMID:22342832 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression
multiple interactions
ISO Berberine results in decreased expression of CYP2E1 mRNA
Berberine inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]
CTD PMID:22342832 PMID:25455889 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
decreases expression
decreases activity
EXP
ISO
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
Berberine results in decreased expression of CYP3A4 mRNA; Berberine results in decreased expression of CYP3A4 protein
Berberine results in decreased activity of CYP3A4 protein
Atorvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Atorvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Atorvastatin results in decreased expression of CYP3A4 mRNA]; Berberine promotes the reaction [Atorvastatin results in decreased expression of CYP3A4 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Simvastatin results in decreased expression of CYP3A4 protein]; Simvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein]
CTD PMID:21524698 PMID:30086269 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DKK1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions EXP DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein] CTD PMID:26478571 NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042
JBrowse link
G DNMT1 DNA methyltransferase 1 decreases expression EXP Berberine results in decreased expression of DNMT1 mRNA CTD PMID:27311644 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286
JBrowse link
G DNMT3B DNA methyltransferase 3 beta decreases expression EXP Berberine results in decreased expression of DNMT3B mRNA CTD PMID:27311644 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359
JBrowse link
G DZIP3 DAZ interacting zinc finger protein 3 increases expression EXP Berberine results in increased expression of DZIP3 mRNA CTD PMID:27311644 NCBI chr 3:108,589,510...108,694,840
Ensembl chr 3:108,589,705...108,694,840
JBrowse link
G EGF epidermal growth factor multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein] CTD PMID:33325633 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFR epidermal growth factor receptor decreases expression EXP Berberine results in decreased expression of EGFR protein CTD PMID:33325633 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP Berberine results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein CTD PMID:23363784 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G EP300 E1A binding protein p300 increases expression EXP Berberine results in increased expression of EP300 mRNA CTD PMID:27311644 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,510...41,180,077
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 multiple interactions EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Berberine results in decreased expression of ERBB2 protein]; Berberine results in decreased expression of and results in increased ubiquitination of ERBB2 protein CTD PMID:33325633 NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP Berberine inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESRRA estrogen related receptor alpha multiple interactions EXP Berberine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr11:64,305,524...64,316,743
Ensembl chr11:64,305,497...64,316,743
JBrowse link
G FABP4 fatty acid binding protein 4 decreases expression
increases expression
multiple interactions
EXP
ISO
Berberine results in decreased expression of FABP4 mRNA
Berberine results in increased expression of FABP4 mRNA
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of FABP4 mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of FABP4 mRNA]
CTD PMID:26478571 PMID:29408570 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FAS Fas cell surface death receptor multiple interactions
increases expression
ISO
EXP
[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA; Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA]
Berberine results in increased expression of FAS mRNA; Berberine results in increased expression of FAS protein
CTD PMID:20564506 PMID:20656010 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FASLG Fas ligand increases expression EXP Berberine results in increased expression of FASLG mRNA; Berberine results in increased expression of FASLG protein CTD PMID:20656010 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in increased expression of FN1 mRNA]
Berberine inhibits the reaction [Particulate Matter results in increased expression of FN1 mRNA]
CTD PMID:30138605 PMID:37839514 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FOXO1 forkhead box O1 multiple interactions EXP [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO1 protein; Berberine results in increased expression of and results in increased acetylation of FOXO1 protein CTD PMID:26712469 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G FOXO3 forkhead box O3 multiple interactions EXP [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein; Berberine results in increased expression of and results in increased acetylation of FOXO3 protein CTD PMID:26712469 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G FUNDC1 FUN14 domain containing 1 increases expression
multiple interactions
EXP Berberine results in increased expression of FUNDC1 protein
[Cisplatin co-treated with Berberine] results in increased expression of FUNDC1 protein; FUNDC1 protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]
CTD PMID:36070022 NCBI chr  X:44,523,639...44,542,859
Ensembl chr  X:44,523,639...44,542,859
JBrowse link
G GATA2 GATA binding protein 2 increases expression ISO Berberine results in increased expression of GATA2 mRNA CTD PMID:37511356 NCBI chr 3:128,479,422...128,493,201
Ensembl chr 3:128,479,427...128,493,201
JBrowse link
G GATA3 GATA binding protein 3 increases expression ISO Berberine results in increased expression of GATA3 mRNA CTD PMID:37511356 NCBI chr10:8,045,333...8,075,198
Ensembl chr10:8,045,378...8,075,198
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of GCLC mRNA] CTD PMID:35121005 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of GCLM mRNA] CTD PMID:35121005 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GDF5 growth differentiation factor 5 decreases expression EXP Berberine results in decreased expression of GDF5 mRNA CTD PMID:26478571 NCBI chr20:35,433,347...35,454,749
Ensembl chr20:35,433,347...35,454,746
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of GFAP mRNA] CTD PMID:35121005 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Berberine inhibits the reaction [Ethanol results in increased activity of GPT protein]
Berberine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Berberine inhibits the reaction [Thioacetamide results in increased activity of GPT protein]
CTD PMID:24751971 PMID:25455889 PMID:30138605 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of GPX1 mRNA] CTD PMID:24751971 PMID:33460233 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO
EXP
Berberine inhibits the reaction [Dexamethasone results in decreased expression of GSK3B mRNA]
Berberine results in increased phosphorylation of GSK3B protein
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]
CTD PMID:20462044 PMID:23954465 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Berberine inhibits the reaction [Chlorpyrifos results in decreased activity of GSR protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein] CTD PMID:24751971 PMID:25600690 PMID:33460233 PMID:35439518 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G H2AC11 H2A clustered histone 11 decreases expression EXP Berberine results in decreased expression of H2AC11 mRNA CTD PMID:27311644 NCBI chr 6:27,133,043...27,133,535
Ensembl chr 6:27,133,043...27,135,292
JBrowse link
G H2AC12 H2A clustered histone 12 decreases expression EXP Berberine results in decreased expression of H2AC12 mRNA CTD PMID:27311644 NCBI chr 6:27,147,106...27,147,562
Ensembl chr 6:27,147,106...27,147,562
JBrowse link
G H2AC14 H2A clustered histone 14 decreases expression EXP Berberine results in decreased expression of H2AC14 mRNA CTD PMID:27311644 NCBI chr 6:27,814,302...27,814,777
Ensembl chr 6:27,814,302...27,814,777
JBrowse link
G H2AC15 H2A clustered histone 15 decreases expression EXP Berberine results in decreased expression of H2AC15 mRNA CTD PMID:27311644 NCBI chr 6:27,837,880...27,838,375
Ensembl chr 6:27,835,508...27,838,375
JBrowse link
G H2AC17 H2A clustered histone 17 decreases expression EXP Berberine results in decreased expression of H2AC17 mRNA CTD PMID:27311644 NCBI chr 6:27,892,699...27,893,185
Ensembl chr 6:27,892,699...27,893,185
JBrowse link
G H2AC18 H2A clustered histone 18 decreases expression EXP Berberine results in decreased expression of H2AC18 mRNA CTD PMID:27311644 NCBI chr 1:149,842,218...149,842,750
Ensembl chr 1:149,842,218...149,842,750
JBrowse link
G H2AC25 H2A clustered histone 25 decreases expression EXP Berberine results in decreased expression of H2AC25 mRNA CTD PMID:27311644 NCBI chr 1:228,457,364...228,457,873
Ensembl chr 1:228,434,777...228,457,873
JBrowse link
G H2AC4 H2A clustered histone 4 decreases expression EXP Berberine results in decreased expression of H2AC4 mRNA CTD PMID:27311644 NCBI chr 6:26,033,092...26,033,618
Ensembl chr 6:26,033,092...26,033,618
JBrowse link
G H2AC6 H2A clustered histone 6 decreases expression EXP Berberine results in decreased expression of H2AC6 mRNA CTD PMID:27311644 NCBI chr 6:26,124,172...26,124,690
Ensembl chr 6:26,124,145...26,139,116
JBrowse link
G H2AC8 H2A clustered histone 8 decreases expression EXP Berberine results in decreased expression of H2AC8 mRNA CTD PMID:27311644 NCBI chr 6:26,216,921...26,217,437
Ensembl chr 6:26,216,921...26,218,515
JBrowse link
G H2AX H2A.X variant histone increases expression
decreases expression
multiple interactions
EXP Berberine results in increased expression of H2AX protein modified form
Berberine results in decreased expression of H2AX mRNA; Berberine results in decreased expression of H2AX protein
TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
CTD PMID:23363784 PMID:23747414 PMID:27311644 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465
JBrowse link
G H2BC11 H2B clustered histone 11 decreases expression EXP Berberine results in decreased expression of H2BC11 mRNA CTD PMID:27311644 NCBI chr 6:27,132,316...27,132,795
Ensembl chr 6:27,122,657...27,132,795
JBrowse link
G H2BC12 H2B clustered histone 12 decreases expression EXP Berberine results in decreased expression of H2BC12 mRNA CTD PMID:27311644 NCBI chr 6:27,138,293...27,146,858
Ensembl chr 6:27,137,298...27,146,855
JBrowse link
G H2BC13 H2B clustered histone 13 decreases expression EXP Berberine results in decreased expression of H2BC13 mRNA CTD PMID:27311644 NCBI chr 6:27,807,479...27,807,929
Ensembl chr 6:27,807,479...27,807,929
JBrowse link
G H2BC14 H2B clustered histone 14 decreases expression EXP Berberine results in decreased expression of H2BC14 mRNA CTD PMID:27311644 NCBI chr 6:27,815,022...27,815,489
Ensembl chr 6:27,815,022...27,815,489
JBrowse link
G H2BC15 H2B clustered histone 15 decreases expression EXP Berberine results in decreased expression of H2BC15 mRNA CTD PMID:27311644 NCBI chr 6:27,838,569...27,839,110
Ensembl chr 6:27,838,545...27,855,709
JBrowse link
G H2BC17 H2B clustered histone 17 decreases expression EXP Berberine results in decreased expression of H2BC17 mRNA CTD PMID:27311644 NCBI chr 6:27,893,425...27,893,891
Ensembl chr 6:27,893,425...27,893,891
JBrowse link
G H2BC4 H2B clustered histone 4 decreases expression EXP Berberine results in decreased expression of H2BC4 mRNA CTD PMID:27311644 NCBI chr 6:26,113,170...26,123,926
Ensembl chr 6:26,086,317...26,123,926
JBrowse link
G H2BC5 H2B clustered histone 5 decreases expression EXP Berberine results in decreased expression of H2BC5 mRNA CTD PMID:27311644 NCBI chr 6:26,158,121...26,171,349
Ensembl chr 6:26,158,122...26,171,349
JBrowse link
G H2BC6 H2B clustered histone 6 decreases expression EXP Berberine results in decreased expression of H2BC6 mRNA CTD PMID:27311644 NCBI chr 6:26,183,761...26,184,230
Ensembl chr 6:26,172,059...26,184,655
JBrowse link
G H2BC7 H2B clustered histone 7 decreases expression EXP Berberine results in decreased expression of H2BC7 mRNA CTD PMID:27311644 NCBI chr 6:26,199,516...26,199,988
Ensembl chr 6:26,199,516...26,199,988
JBrowse link
G H2BC8 H2B clustered histone 8 decreases expression EXP Berberine results in decreased expression of H2BC8 mRNA CTD PMID:27311644 NCBI chr 6:26,216,200...26,216,688
Ensembl chr 6:26,216,200...26,216,688
JBrowse link
G H2BC9 H2B clustered histone 9 decreases expression EXP Berberine results in decreased expression of H2BC9 mRNA CTD PMID:27311644 NCBI chr 6:26,251,614...26,252,075
Ensembl chr 6:26,251,614...26,252,075
JBrowse link
G H2BW2 H2B.W histone 2 decreases expression EXP Berberine results in decreased expression of H2BW2 mRNA CTD PMID:27311644 NCBI chr  X:104,039,956...104,042,454
Ensembl chr  X:104,039,956...104,042,454
JBrowse link
G H3-3A H3.3 histone A decreases expression EXP Berberine results in decreased expression of H3-3A mRNA CTD PMID:27311644 NCBI chr 1:226,061,831...226,072,019
Ensembl chr 1:226,061,851...226,072,019
JBrowse link
G H3-4 H3.4 histone, cluster member decreases expression EXP Berberine results in decreased expression of H3-4 mRNA CTD PMID:27311644 NCBI chr 1:228,424,845...228,425,360
Ensembl chr 1:228,424,845...228,425,360
JBrowse link
G H3C1 H3 clustered histone 1 decreases expression EXP Berberine results in decreased expression of H3C1 mRNA CTD PMID:27311644 NCBI chr 6:26,020,451...26,020,958
Ensembl chr 6:26,020,451...26,020,958
JBrowse link
G H3C10 H3 clustered histone 10 decreases expression EXP Berberine results in decreased expression of H3C10 mRNA CTD PMID:27311644 NCBI chr 6:27,810,051...27,810,536
Ensembl chr 6:27,810,051...27,811,300
JBrowse link
G H3C12 H3 clustered histone 12 decreases expression EXP Berberine results in decreased expression of H3C12 mRNA CTD PMID:27311644 NCBI chr 6:27,890,315...27,890,826
Ensembl chr 6:27,890,315...27,893,106
JBrowse link
G H3C2 H3 clustered histone 2 decreases expression EXP Berberine results in decreased expression of H3C2 mRNA CTD PMID:27311644 NCBI chr 6:26,031,589...26,032,099
Ensembl chr 6:26,031,589...26,032,099
JBrowse link
G H3C4 H3 clustered histone 4 decreases expression EXP Berberine results in decreased expression of H3C4 mRNA CTD PMID:27311644 NCBI chr 6:26,196,784...26,199,293
Ensembl chr 6:26,195,164...26,197,286
JBrowse link
G H3C7 H3 clustered histone 7 decreases expression EXP Berberine results in decreased expression of H3C7 mRNA CTD PMID:27311644 NCBI chr 6:26,250,142...26,250,635
Ensembl chr 6:26,250,142...26,250,635
JBrowse link
G H3C8 H3 clustered histone 8 decreases expression EXP Berberine results in decreased expression of H3C8 mRNA CTD PMID:27311644 NCBI chr 6:26,270,918...26,271,413
Ensembl chr 6:26,270,918...26,271,413
JBrowse link
G H4C14 H4 clustered histone 14 decreases expression EXP Berberine results in decreased expression of H4C14 mRNA CTD PMID:27311644 NCBI chr 1:149,832,657...149,833,052
Ensembl chr 1:149,832,657...149,839,767
JBrowse link
G H4C2 H4 clustered histone 2 decreases expression EXP Berberine results in decreased expression of H4C2 mRNA CTD PMID:27311644 NCBI chr 6:26,026,896...26,027,283
Ensembl chr 6:26,025,802...26,027,283
JBrowse link
G H4C3 H4 clustered histone 3 decreases expression EXP Berberine results in decreased expression of H4C3 mRNA CTD PMID:27311644 NCBI chr 6:26,103,933...26,104,337
Ensembl chr 6:26,103,933...26,104,337
JBrowse link
G H4C8 H4 clustered histone 8 decreases expression EXP Berberine results in decreased expression of H4C8 mRNA CTD PMID:27311644 NCBI chr 6:26,285,126...26,285,534
Ensembl chr 6:26,277,609...26,285,638
JBrowse link
G H4C9 H4 clustered histone 9 decreases expression EXP Berberine results in decreased expression of H4C9 mRNA CTD PMID:27311644 NCBI chr 6:27,139,282...27,139,678
Ensembl chr 6:27,139,282...27,140,640
JBrowse link
G HAT1 histone acetyltransferase 1 increases expression EXP Berberine results in increased expression of HAT1 mRNA CTD PMID:27311644 NCBI chr 2:171,922,461...171,983,686
Ensembl chr 2:171,922,448...171,983,686
JBrowse link
G HDAC2 histone deacetylase 2 decreases expression EXP Berberine results in decreased expression of HDAC2 mRNA CTD PMID:27311644 NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308
JBrowse link
G HDAC5 histone deacetylase 5 increases expression EXP Berberine results in increased expression of HDAC5 mRNA CTD PMID:27311644 NCBI chr17:44,076,753...44,123,641
Ensembl chr17:44,076,746...44,123,702
JBrowse link
G HDAC8 histone deacetylase 8 decreases expression EXP Berberine results in decreased expression of HDAC8 mRNA CTD PMID:27311644 NCBI chr  X:72,329,516...72,572,843
Ensembl chr  X:72,329,516...72,573,101
JBrowse link
G HDAC9 histone deacetylase 9 decreases expression
increases expression
EXP Berberine results in decreased expression of HDAC9 mRNA
Berberine results in increased expression of HDAC9 mRNA
CTD PMID:27311644 NCBI chr 7:18,086,825...19,002,416
Ensembl chr 7:18,086,949...19,002,416
JBrowse link
G HGF hepatocyte growth factor multiple interactions
increases expression
ISO
EXP
Berberine inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF mRNA]; 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Berberine results in increased expression of HGF protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF protein]; Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein]; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
Berberine results in increased expression of HGF mRNA; Berberine results in increased expression of HGF protein
CTD PMID:29408570 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G HMGB1 high mobility group box 1 multiple interactions ISO Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of HMGB1 protein] CTD PMID:38705399 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
Berberine results in increased expression of HMOX1 protein
Berberine results in increased expression of HMOX1 mRNA; Berberine results in increased expression of HMOX1 protein
Berberine inhibits the reaction [Particulate Matter results in decreased expression of HMOX1 protein]
Berberine inhibits the reaction [Bortezomib results in increased expression of HMOX1 mRNA]
Berberine promotes the reaction [Glucose results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]
CTD PMID:23954465 PMID:35121005 PMID:37511356 PMID:37839514 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha multiple interactions ISO Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]
Berberine inhibits the reaction [Ethanol results in decreased expression of HNF4 protein]
CTD PMID:18563319 PMID:25455889 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845
JBrowse link
G IDH3A isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression EXP Berberine results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr15:78,149,362...78,171,945
Ensembl chr15:78,131,498...78,171,945
JBrowse link
G IFNG interferon gamma multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in increased expression of IFNG mRNA] CTD PMID:30138605 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF1R insulin like growth factor 1 receptor multiple interactions
increases expression
EXP Berberine inhibits the reaction [Glucose results in decreased expression of IGF1R protein]
Berberine results in increased expression of IGF1R protein
CTD PMID:23954465 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 multiple interactions
decreases expression
EXP
ISO
[Chloroquine co-treated with Berberine] results in decreased expression of IGF2BP3 protein; Berberine promotes the reaction [IGF2BP3 protein binds to TRIM21 protein]; Cycloheximide promotes the reaction [Berberine results in decreased expression of IGF2BP3 protein]
Berberine inhibits the reaction [[Dextran Sulfate co-treated with azomethane] results in increased expression of IGF2BP3 protein]
CTD PMID:36822301 NCBI chr 7:23,310,209...23,470,491
Ensembl chr 7:23,310,209...23,470,491
JBrowse link
G IL10 interleukin 10 multiple interactions
increases expression
ISO Berberine affects the reaction [Lipopolysaccharides affects the expression of IL10 mRNA]
[Berberine co-treated with Thioacetamide] results in increased expression of IL10 mRNA; Berberine inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]
Berberine results in increased expression of IL10 mRNA
CTD PMID:21867779 PMID:30138605 PMID:37955270 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Bortezomib results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL1B mRNA]
CTD PMID:16391493 PMID:29170048 PMID:30138605 PMID:35121005 PMID:35691465 More... NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 increases expression ISO Berberine results in increased expression of IL2 mRNA CTD PMID:21867779 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL23A interleukin 23 subunit alpha multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein] CTD PMID:30240693 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410
JBrowse link
G IL4 interleukin 4 multiple interactions
increases expression
ISO Berberine inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 mRNA]
Berberine results in increased expression of IL4 mRNA
CTD PMID:21867779 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions ISO
EXP
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; Berberine inhibits the reaction [Bortezomib results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]; Berberine inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]
CTD PMID:28916288 PMID:29170048 PMID:30138605 PMID:30240693 PMID:34427876 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS insulin multiple interactions ISO [Berberine co-treated with Streptozocin] results in increased secretion of INS protein CTD PMID:15066220 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G ITGA1 integrin subunit alpha 1 increases expression EXP Berberine results in increased expression of ITGA1 mRNA CTD PMID:26478571 NCBI chr 5:52,787,916...52,959,209
Ensembl chr 5:52,787,916...52,959,209
JBrowse link
G ITGB4 integrin subunit beta 4 increases expression EXP berberine increases expression of ITGB4 protein in colon epithelial cells RGD PMID:29564000 RGD:152995489 NCBI chr17:75,721,459...75,757,818
Ensembl chr17:75,721,328...75,757,818
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit affects localization
multiple interactions
ISO Berberine affects the localization of JUN protein
arsenic trioxide promotes the reaction [Berberine affects the localization of JUN protein]
CTD PMID:18294404 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO Berberine results in decreased activity of KCNH2 protein
Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein]
CTD PMID:30086269 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KDM1A lysine demethylase 1A increases expression EXP Berberine results in increased expression of KDM1A mRNA CTD PMID:27311644 NCBI chr 1:23,019,468...23,083,689
Ensembl chr 1:23,019,443...23,083,689
JBrowse link
G KDM4A lysine demethylase 4A increases expression EXP Berberine results in increased expression of KDM4A mRNA CTD PMID:27311644 NCBI chr 1:43,650,149...43,705,518
Ensembl chr 1:43,650,149...43,705,518
JBrowse link
G KDM5B lysine demethylase 5B increases expression EXP Berberine results in increased expression of KDM5B mRNA CTD PMID:27311644 NCBI chr 1:202,724,495...202,808,421
Ensembl chr 1:202,724,495...202,808,487
JBrowse link
G KDM6A lysine demethylase 6A increases expression EXP Berberine results in increased expression of KDM6A mRNA CTD PMID:27311644 NCBI chr  X:44,873,188...45,112,779
Ensembl chr  X:44,873,188...45,112,779
JBrowse link
G KDM6B lysine demethylase 6B increases expression EXP Berberine results in increased expression of KDM6B mRNA CTD PMID:27311644 NCBI chr17:7,834,217...7,854,796
Ensembl chr17:7,834,217...7,854,796
JBrowse link
G KMT5A lysine methyltransferase 5A increases expression EXP Berberine results in increased expression of KMT5A mRNA CTD PMID:27311644 NCBI chr12:123,384,132...123,409,353
Ensembl chr12:123,384,132...123,409,353
JBrowse link
G KPNA4 karyopherin subunit alpha 4 multiple interactions EXP Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of NFKBIA protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of RELA protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]] CTD PMID:34427876 NCBI chr 3:160,495,007...160,565,571
Ensembl chr 3:160,495,007...160,565,571
JBrowse link
G LDLR low density lipoprotein receptor multiple interactions
increases expression
ISO Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]
Berberine results in increased expression of LDLR mRNA
Berberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]; Simvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]
CTD PMID:18640378 PMID:20564506 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820
JBrowse link
G LINC00943 long intergenic non-protein coding RNA 943 multiple interactions EXP Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of LINC00943 mRNA]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]] CTD PMID:34427876 NCBI chr12:126,737,007...126,746,256
Ensembl chr12:126,723,412...126,749,027
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions
increases localization
EXP
ISO
[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein; Berberine results in increased expression of and results in increased lipidation of MAP1LC3B protein; BNIP3L protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]; FUNDC1 protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]
Berberine results in increased localization of MAP1LC3B protein
Berberine inhibits the reaction [Chlorpyrifos results in decreased expression of MAP1LC3B mRNA]
CTD PMID:35439518 PMID:36070022 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein] CTD PMID:30240693 NCBI chr 6:136,557,046...136,793,091
Ensembl chr 6:136,557,046...136,793,097
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation ISO Berberine results in decreased phosphorylation of MAPK1 protein CTD PMID:18294404 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO Berberine results in decreased phosphorylation of MAPK3 protein
Berberine inhibits the reaction [Dexamethasone results in decreased expression of MAPK3 mRNA]
CTD PMID:18294404 PMID:20462044 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP [Berberine co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein] CTD PMID:36070022 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPT microtubule associated protein tau multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] CTD PMID:29170048 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
JBrowse link
G MCM2 minichromosome maintenance complex component 2 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in increased expression of MCM2 mRNA] CTD PMID:20462044 NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,223...127,622,436
JBrowse link
G MIR142 microRNA 142 multiple interactions EXP Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of MIR142 mRNA]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]] CTD PMID:34427876 NCBI chr17:58,331,232...58,331,318
Ensembl chr17:58,331,232...58,331,318
JBrowse link
G MIR19A microRNA 19a decreases expression EXP Berberine results in decreased expression of MIR19A mRNA CTD PMID:29687521 NCBI chr13:91,350,891...91,350,972
Ensembl chr13:91,350,891...91,350,972
JBrowse link
G MIR21 microRNA 21 decreases expression EXP berberine decreases expression of MIR21 RNA in colon epithelial cell RGD PMID:29564000 RGD:152995489 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
G MIR92A1 microRNA 92a-1 decreases expression EXP Berberine results in decreased expression of MIR92A1 mRNA CTD PMID:29687521 NCBI chr13:91,351,314...91,351,391
Ensembl chr13:91,351,314...91,351,391
JBrowse link
G MMP13 matrix metallopeptidase 13 increases expression EXP Berberine results in increased expression of MMP13 mRNA CTD PMID:26478571 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MMP14 matrix metallopeptidase 14 multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP14 protein] CTD PMID:18294404 NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,041
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; Arsenic Trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; Berberine promotes the reaction [Arsenic Trioxide results in decreased activity of MMP2 protein]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]
Berberine results in decreased expression of MMP2 protein
arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]
CTD PMID:18294404 PMID:33325633 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases activity
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein] CTD PMID:33325633 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPO myeloperoxidase multiple interactions ISO Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:21963898 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I multiple interactions ISO Berberine inhibits the reaction [acetamiprid results in decreased expression of COX1 mRNA] CTD PMID:37350525 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445
JBrowse link
G MT-ND1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions ISO Berberine inhibits the reaction [acetamiprid results in decreased expression of ND1 mRNA] CTD PMID:37350525 NCBI chr MT:3,307...4,262
Ensembl chr MT:3,307...4,262
JBrowse link
G MT-ND2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 multiple interactions ISO Berberine inhibits the reaction [acetamiprid results in decreased expression of ND2 mRNA] CTD PMID:37350525 NCBI chr MT:4,470...5,511
Ensembl chr MT:4,470...5,511
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions ISO Berberine inhibits the reaction [Chlorpyrifos results in increased expression of MTOR mRNA]; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of MTOR protein] CTD PMID:35439518 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
JBrowse link
G MTTP microsomal triglyceride transfer protein multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of MTTP protein] CTD PMID:25455889 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,564,081...99,623,997
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions
affects localization
ISO arsenic trioxide promotes the reaction [Berberine affects the localization of MYC protein] CTD PMID:18294404 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase multiple interactions
decreases expression
EXP [Berberine co-treated with Niacinamide] results in decreased expression of NAMPT protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of NAMPT protein] CTD PMID:26712469 NCBI chr 7:106,248,298...106,285,888
Ensembl chr 7:106,248,298...106,285,966
JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions EXP Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to NCF1 protein] CTD PMID:36070022 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315
JBrowse link
G NCF2 neutrophil cytosolic factor 2 multiple interactions EXP Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to NCF2 protein] CTD PMID:36070022 NCBI chr 1:183,555,562...183,601,849
Ensembl chr 1:183,554,461...183,590,905
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
increases activity
EXP
ISO
Berberine results in increased expression of NFE2L2 protein
Berberine inhibits the reaction [Particulate Matter results in decreased expression of NFE2L2 protein]
Berberine results in increased activity of NFE2L2 protein
Berberine inhibits the reaction [Bortezomib results in increased expression of NFE2L2 mRNA]; Berberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein]
NFE2L2 mutant form inhibits the reaction [Berberine inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein]
CTD PMID:23523906 PMID:23954465 PMID:30818834 PMID:35121005 PMID:37839514 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of NFKB1 mRNA] CTD PMID:35121005 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO
EXP
Berberine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of NFKBIA protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of NFKBIA protein]]
CTD PMID:21963898 PMID:34427876 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NGF nerve growth factor multiple interactions EXP Berberine inhibits the reaction [Glucose results in decreased expression of NGF protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein] CTD PMID:23954465 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of NLRP3 mRNA]
Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 mRNA]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 protein]
CTD PMID:35121005 PMID:38705399 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
Berberine inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]
CTD PMID:21095217 PMID:23523906 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Berberine reverses reaction [Carbontetrachloride decreases Nqo1 mRNA in liver]
Berberine inhibits the reaction [Bortezomib results in increased expression of NQO1 mRNA]
CTD
RGD
PMID:35121005 PMID:31432116 RGD:25823187 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 increases localization EXP Berberine increases localization of NR1H3 protein in macrophage nucleus RGD PMID:20506155 RGD:401827279 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity
multiple interactions
EXP Berberine results in increased activity of NR1I2 protein
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:21524698 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP Berberine results in increased activity of NR1I3 protein CTD PMID:30818834 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244
JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 decreases expression EXP Berberine results in decreased expression of NSD2 mRNA CTD PMID:27311644 NCBI chr 4:1,871,393...1,982,192
Ensembl chr 4:1,871,393...1,982,207
JBrowse link
G ODC1 ornithine decarboxylase 1 multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of ODC1 protein] CTD PMID:18294404 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G OMD osteomodulin increases expression EXP Berberine results in increased expression of OMD mRNA CTD PMID:26478571 NCBI chr 9:92,412,380...92,424,471
Ensembl chr 9:92,412,380...92,424,471
JBrowse link
G P2RX7 purinergic receptor P2X 7 multiple interactions EXP Berberine affects the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] CTD PMID:21320518 NCBI chr12:121,132,876...121,188,032
Ensembl chr12:121,132,819...121,188,032
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions
EXP Berberine results in increased cleavage of PARP1 protein
[Berberine co-treated with Cisplatin] results in increased cleavage of PARP1 protein; [Berberine co-treated with Niacinamide] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of PARP1 protein]
CTD PMID:16505103 PMID:26712469 PMID:36070022 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PDCD4 programmed cell death 4 increases expression EXP Berberine increases expression of PDCD4 protein in colon epithelial cells RGD PMID:29564000 RGD:152995489 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 increases expression ISO Berberine results in increased expression of PDK4 mRNA CTD PMID:37511356 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]
Berberine inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of PPARA protein]
CTD PMID:18338635 PMID:25455889 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
JBrowse link
G PPARD peroxisome proliferator activated receptor delta increases activity
multiple interactions
increases expression
ISO Berberine results in increased activity of PPARD protein
Berberine inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of PPARD protein]
Berberine results in increased expression of PPARD mRNA; Berberine results in increased expression of PPARD protein
CTD PMID:18338635 PMID:37511356 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
decreases expression
increases response to substance
increases expression
ISO
EXP
Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]
Berberine inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in decreased expression of PPARG protein]
Berberine results in decreased expression of PPARG mRNA; Berberine results in decreased expression of PPARG protein
PPARG mRNA results in increased susceptibility to Berberine
15-deoxyprostaglandin J2 promotes the reaction [Berberine affects the localization of and results in increased activity of PPARG protein]; Berberine inhibits the reaction [Bleomycin binds to PPARG protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 affects the localization of and results in increased activity of PPARG protein]; Berberine results in increased activity of and affects the localization of PPARG protein; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
Berberine results in increased expression of PPARG mRNA
CTD PMID:18338635 PMID:20564506 PMID:26478571 PMID:29408570 PMID:37511356 More... NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA] CTD PMID:25455889 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRG4 proteoglycan 4 decreases expression EXP Berberine results in decreased expression of PRG4 mRNA CTD PMID:26478571 NCBI chr 1:186,296,273...186,314,567
Ensembl chr 1:186,296,279...186,314,567
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO Berberine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374
JBrowse link
G PRKCA protein kinase C alpha multiple interactions ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCA protein]; Berberine results in decreased activity of and affects the localization of PRKCA protein CTD PMID:18294404 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PRKCE protein kinase C epsilon multiple interactions
decreases activity
ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCE protein]; Berberine results in decreased activity of and affects the localization of PRKCE protein CTD PMID:18294404 NCBI chr 2:45,651,279...46,187,990
Ensembl chr 2:45,651,345...46,187,990
JBrowse link
G PRMT1 protein arginine methyltransferase 1 decreases expression EXP Berberine results in decreased expression of PRMT1 mRNA CTD PMID:27311644 NCBI chr19:49,676,153...49,688,447
Ensembl chr19:49,675,786...49,689,029
JBrowse link
G PRMT2 protein arginine methyltransferase 2 increases expression EXP Berberine results in increased expression of PRMT2 mRNA CTD PMID:27311644 NCBI chr21:46,635,674...46,665,124
Ensembl chr21:46,635,595...46,665,685
JBrowse link
G PRMT5 protein arginine methyltransferase 5 increases expression EXP Berberine results in increased expression of PRMT5 mRNA CTD PMID:27311644 NCBI chr14:22,920,529...22,929,376
Ensembl chr14:22,920,525...22,929,408
JBrowse link
G PRMT6 protein arginine methyltransferase 6 increases expression EXP Berberine results in increased expression of PRMT6 mRNA CTD PMID:27311644 NCBI chr 1:107,056,674...107,059,294
Ensembl chr 1:107,056,674...107,067,636
JBrowse link
G PRMT7 protein arginine methyltransferase 7 increases expression EXP Berberine results in increased expression of PRMT7 mRNA CTD PMID:27311644 NCBI chr16:68,311,019...68,360,870
Ensembl chr16:68,310,951...68,360,852
JBrowse link
G PRMT8 protein arginine methyltransferase 8 increases expression EXP Berberine results in increased expression of PRMT8 mRNA CTD PMID:27311644 NCBI chr12:3,381,349...3,593,973
Ensembl chr12:3,381,349...3,593,973
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions
increases expression
ISO ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN protein]
Berberine results in increased expression of PTEN protein
CTD PMID:29408570 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] CTD PMID:21095217 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions ISO Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of PYCARD mRNA] CTD PMID:38705399 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
JBrowse link
G RAC2 Rac family small GTPase 2 multiple interactions EXP Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to RAC2 protein]; Berberine results in increased expression of and results in increased activity of RAC2 protein CTD PMID:36070022 NCBI chr22:37,225,270...37,244,269
Ensembl chr22:37,225,270...37,259,594
JBrowse link
G RBP4 retinol binding protein 4 multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr10:93,591,694...93,601,744
Ensembl chr10:93,591,687...93,601,744
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
Berberine inhibits the reaction [Bleomycin affects the localization of and results in increased expression of RELA protein]
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of RELA protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of RELA protein]]
CTD PMID:23523906 PMID:34427876 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RLN1 relaxin 1 affects binding
increases expression
multiple interactions
ISO Berberine binds to RLN1 promoter
Berberine results in increased expression of RLN1 mRNA
[Berberine binds to RLN1 promoter] which results in increased expression of RLN1 mRNA
CTD PMID:22363579 NCBI chr 9:5,334,930...5,340,916
Ensembl chr 9:5,334,930...5,339,876
JBrowse link
G RPS6 ribosomal protein S6 decreases phosphorylation EXP Berberine results in decreased phosphorylation of RPS6 protein CTD PMID:23363784 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions
increases expression
EXP CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA] CTD PMID:26478571 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G SETD1B SET domain containing 1B, histone lysine methyltransferase increases expression EXP Berberine results in increased expression of SETD1B mRNA CTD PMID:27311644 NCBI chr12:121,790,155...121,832,656
Ensembl chr12:121,804,009...121,832,656
JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase increases expression EXP Berberine results in increased expression of SETD2 mRNA CTD PMID:27311644 NCBI chr 3:47,016,436...47,164,840
Ensembl chr 3:47,016,428...47,164,113
JBrowse link
G SETD3 SET domain containing 3, actin N3(tau)-histidine methyltransferase increases expression EXP Berberine results in increased expression of SETD3 mRNA CTD PMID:27311644 NCBI chr14:99,397,748...99,486,458
Ensembl chr14:99,397,748...99,480,889
JBrowse link
G SETD5 SET domain containing 5 increases expression EXP Berberine results in increased expression of SETD5 mRNA CTD PMID:27311644 NCBI chr 3:9,397,615...9,478,154
Ensembl chr 3:9,397,615...9,479,240
JBrowse link
G SETD6 SET domain containing 6, protein lysine methyltransferase increases expression EXP Berberine results in increased expression of SETD6 mRNA CTD PMID:27311644 NCBI chr16:58,515,479...58,523,842
Ensembl chr16:58,515,479...58,523,842
JBrowse link
G SETD7 SET domain containing 7, histone lysine methyltransferase increases expression EXP Berberine results in increased expression of SETD7 mRNA CTD PMID:27311644 NCBI chr 4:139,492,974...139,556,219
Ensembl chr 4:139,495,941...139,606,699
JBrowse link
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 increases expression EXP Berberine results in increased expression of SETDB1 mRNA CTD PMID:27311644 NCBI chr 1:150,926,263...150,964,737
Ensembl chr 1:150,926,263...150,964,744
JBrowse link
G SETDB2 SET domain bifurcated histone lysine methyltransferase 2 increases expression EXP Berberine results in increased expression of SETDB2 mRNA CTD PMID:27311644 NCBI chr13:49,444,274...49,495,003
Ensembl chr13:49,444,274...49,495,003
JBrowse link
G SI sucrase-isomaltase decreases expression
multiple interactions
EXP
ISO
Berberine results in decreased expression of SI mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA]
CTD PMID:20229011 NCBI chr 3:164,978,898...165,090,232
Ensembl chr 3:164,978,898...165,078,496
JBrowse link
G SIRT1 sirtuin 1 decreases expression
multiple interactions
EXP
ISO
Berberine results in decreased expression of SIRT1 mRNA; Berberine results in decreased expression of SIRT1 protein
Berberine inhibits the reaction [Bortezomib results in decreased expression of SIRT1 protein]
[Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein]
CTD PMID:26712469 PMID:35121005 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SIRT2 sirtuin 2 multiple interactions EXP [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein CTD PMID:26712469 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862
JBrowse link
G SIRT3 sirtuin 3 multiple interactions
increases expression
decreases expression
EXP [Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein
Berberine results in increased expression of SIRT3 mRNA
Berberine results in decreased expression of SIRT3 mRNA; Berberine results in decreased expression of SIRT3 protein
CTD PMID:26712469 PMID:27311644 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
JBrowse link
G SLC27A5 solute carrier family 27 member 5 decreases expression EXP Berberine results in decreased expression of SLC27A5 mRNA CTD PMID:28038998 NCBI chr19:58,498,333...58,511,992
Ensembl chr19:58,479,512...58,512,413
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein] CTD PMID:19080170 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SLC6A19 solute carrier family 6 member 19 multiple interactions ISO Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 mRNA]; Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 protein] CTD PMID:21073932 NCBI chr 5:1,201,595...1,225,111
Ensembl chr 5:1,201,595...1,225,111
JBrowse link
G SMYD3 SET and MYND domain containing 3 affects expression EXP Berberine affects the expression of SMYD3 mRNA CTD PMID:27311644 NCBI chr 1:245,749,347...246,507,279
Ensembl chr 1:245,749,342...246,507,312
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 multiple interactions ISO Berberine inhibits the reaction [Particulate Matter results in decreased expression of SOCS3 mRNA]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of SOCS3 protein] CTD PMID:37839514 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO Berberine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of SOD1 protein]; Berberine inhibits the reaction [Streptozocin affects the expression of SOD1 mRNA]
Berberine inhibits the reaction [Chlorpyrifos results in decreased activity of SOD1 protein]
CTD PMID:21095217 PMID:22775417 PMID:35439518 PMID:37839514 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO Berberine inhibits the reaction [Streptozocin affects the expression of SOD2 mRNA]
Berberine inhibits the reaction [acetamiprid results in decreased expression of SOD2 mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of SOD2 mRNA]
CTD PMID:22775417 PMID:24751971 PMID:33460233 PMID:37350525 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOX9 SRY-box transcription factor 9 decreases expression EXP Berberine results in decreased expression of SOX9 mRNA CTD PMID:26478571 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416
JBrowse link
G SP7 Sp7 transcription factor increases expression EXP Berberine results in increased expression of SP7 mRNA CTD PMID:26478571 NCBI chr12:53,326,575...53,344,793
Ensembl chr12:53,326,575...53,345,315
JBrowse link
G SPARC secreted protein acidic and cysteine rich increases expression EXP Berberine results in increased expression of SPARC mRNA CTD PMID:26478571 NCBI chr 5:151,661,096...151,686,915
Ensembl chr 5:151,661,096...151,686,975
JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression
multiple interactions
EXP Berberine results in increased expression of SPP1 mRNA; Berberine results in increased expression of SPP1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein]
CTD PMID:26478571 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
JBrowse link
G SQSTM1 sequestosome 1 increases expression
multiple interactions
EXP
ISO
Berberine results in increased expression of SQSTM1 protein
[Berberine co-treated with Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of SQSTM1 protein
CTD PMID:36070022 PMID:38705399 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
ISO
EXP
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Berberine results in decreased expression of SREBF1 mRNA
CTD PMID:20564506 PMID:26478571 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of STAT3 mRNA]
Berberine inhibits the reaction [Particulate Matter results in increased expression of STAT3 mRNA]
CTD PMID:35121005 PMID:37839514 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G TERT telomerase reverse transcriptase decreases activity EXP Berberine results in decreased activity of TERT protein CTD PMID:25265580 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068
JBrowse link
G TGFB1 transforming growth factor beta 1 decreases expression
multiple interactions
ISO Berberine results in decreased expression of TGFB1 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of TGFB1 mRNA]
Berberine inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
CTD PMID:17973934 PMID:23523906 PMID:30138605 PMID:37839514 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]
Berberine inhibits the reaction [Bortezomib results in increased expression of TLR4 protein]
CTD PMID:21963898 PMID:30240693 PMID:35121005 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion
increases expression
EXP
ISO
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; Berberine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Berberine inhibits the reaction [Bortezomib results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]
Berberine results in increased secretion of TNF protein
Berberine results in increased expression of TNF mRNA
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Berberine inhibits the reaction [Dietary Fats results in increased secretion of TNF protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Particulate Matter results in increased expression of TNF protein]
CTD PMID:16391493 PMID:20656010 PMID:21095217 PMID:21867779 PMID:23523906 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TOP1 DNA topoisomerase I decreases activity EXP Berberine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr20:41,028,822...41,124,487
Ensembl chr20:41,028,822...41,124,487
JBrowse link
G TOP2A DNA topoisomerase II alpha multiple interactions
affects response to substance
EXP TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
TOP2A protein affects the susceptibility to Berberine
CTD PMID:23747414 NCBI chr17:40,388,525...40,417,896
Ensembl chr17:40,388,525...40,417,896
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
EXP Berberine results in increased expression of TP53 mRNA; Berberine results in increased expression of TP53 protein
[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of TP53 protein; Berberine results in increased phosphorylation of and results in increased acetylation of TP53 protein
CTD PMID:20656010 PMID:26712469 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
G TRAF1 TNF receptor associated factor 1 increases expression EXP Berberine results in increased expression of TRAF1 protein CTD PMID:20656010 NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173
JBrowse link
G TRAF2 TNF receptor associated factor 2 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein] CTD PMID:30240693 NCBI chr 9:136,881,958...136,926,607
Ensembl chr 9:136,881,912...136,926,607
JBrowse link
G TRIM21 tripartite motif containing 21 multiple interactions EXP Berberine promotes the reaction [IGF2BP3 protein binds to TRIM21 protein] CTD PMID:36822301 NCBI chr11:4,384,897...4,393,702
Ensembl chr11:4,384,897...4,393,702
JBrowse link
G TSTD1 thiosulfate sulfurtransferase like domain containing 1 increases expression EXP Berberine results in increased expression of TSTD1 mRNA CTD PMID:27311644 NCBI chr 1:161,037,631...161,038,964
Ensembl chr 1:161,037,631...161,038,977
JBrowse link
G UBE2A ubiquitin conjugating enzyme E2 A decreases expression EXP Berberine results in decreased expression of UBE2A mRNA CTD PMID:27311644 NCBI chr  X:119,574,563...119,584,423
Ensembl chr  X:119,474,802...119,591,083
JBrowse link
G UBE2B ubiquitin conjugating enzyme E2 B decreases expression EXP Berberine results in decreased expression of UBE2B mRNA CTD PMID:27311644 NCBI chr 5:134,371,569...134,392,108
Ensembl chr 5:134,371,184...134,392,108
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions
increases expression
ISO Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]
Berberine results in increased expression of UCP2 mRNA
CTD PMID:28533128 PMID:37511356 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,061...73,982,843
JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression EXP Berberine results in decreased expression of VEGFA protein CTD PMID:33325633 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G VEGFC vascular endothelial growth factor C increases expression EXP Berberine results in increased expression of VEGFC mRNA CTD PMID:26478571 NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922
JBrowse link
entacapone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOX3 acyl-CoA oxidase 3, pristanoyl affects binding ISO entacapone binds to ACOX3 protein CTD PMID:19783845 NCBI chr 4:8,355,305...8,440,723
Ensembl chr 4:8,366,282...8,440,723
JBrowse link
G ACSL1 acyl-CoA synthetase long chain family member 1 affects binding ISO entacapone binds to ACSL1 protein CTD PMID:19783845 NCBI chr 4:184,755,595...184,826,594
Ensembl chr 4:184,755,595...184,826,818
JBrowse link
G ADPRHL1 ADP-ribosylhydrolase like 1 affects binding ISO entacapone binds to ADPRHL1 protein CTD PMID:19783845 NCBI chr13:113,399,610...113,453,488
Ensembl chr13:113,399,611...113,453,488
JBrowse link
G AUH AU RNA binding methylglutaconyl-CoA hydratase affects binding ISO entacapone binds to AUH protein CTD PMID:19783845 NCBI chr 9:91,213,823...91,361,918
Ensembl chr 9:91,213,815...91,361,918
JBrowse link
G CLTC clathrin heavy chain affects binding ISO entacapone binds to CLTC protein CTD PMID:19783845 NCBI chr17:59,619,895...59,696,956
Ensembl chr17:59,619,680...59,696,956
JBrowse link
G COMT catechol-O-methyltransferase decreases activity
affects binding
multiple interactions
EXP
ISO
entacapone results in decreased activity of COMT protein
entacapone binds to COMT protein
[entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; entacapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]
CTD PMID:12898346 PMID:15566291 PMID:19783845 PMID:20334432 PMID:23206800 More... NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP entacapone results in increased expression of CXCL8 mRNA CTD PMID:32816093 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 affects binding ISO entacapone binds to ECHS1 protein CTD PMID:19783845 NCBI chr10:133,362,485...133,373,354
Ensembl chr10:133,362,485...133,373,354
JBrowse link
G EREG epiregulin increases expression EXP entacapone results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749
JBrowse link
G GPAM glycerol-3-phosphate acyltransferase, mitochondrial decreases expression EXP entacapone results in decreased expression of GPAM protein CTD PMID:29688484 NCBI chr10:112,149,865...112,227,677
Ensembl chr10:112,149,865...112,215,377
JBrowse link
G HBB hemoglobin subunit beta affects binding ISO entacapone binds to HBB protein CTD PMID:19783845 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395
JBrowse link
G HSD17B13 hydroxysteroid 17-beta dehydrogenase 13 affects binding ISO entacapone binds to HSD17B13 protein CTD PMID:19783845 NCBI chr 4:87,303,794...87,322,882
Ensembl chr 4:87,303,789...87,322,886
JBrowse link
G HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 affects binding ISO entacapone binds to HSD17B4 protein CTD PMID:19783845 NCBI chr 5:119,452,497...119,542,332
Ensembl chr 5:119,452,465...119,637,199
JBrowse link
G IL1A interleukin 1 alpha increases expression EXP entacapone results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta increases expression EXP entacapone results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase increases expression EXP entacapone results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377
JBrowse link
G PC pyruvate carboxylase affects binding ISO entacapone binds to PC protein CTD PMID:19783845 NCBI chr11:66,848,420...66,958,383
Ensembl chr11:66,848,417...66,958,386
JBrowse link
G PID1 phosphotyrosine interaction domain containing 1 decreases expression EXP entacapone results in decreased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 2:229,023,973...229,271,287
Ensembl chr 2:228,850,526...229,271,287
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP entacapone results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G SLC7A11 solute carrier family 7 member 11 decreases expression EXP entacapone results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SLPI secretory leukocyte peptidase inhibitor decreases expression EXP entacapone results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564
JBrowse link
G SNCA synuclein alpha multiple interactions EXP entacapone inhibits the reaction [SNCA protein binds to SNCA protein] CTD PMID:20150427 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 affects binding ISO entacapone binds to SULT2A1 protein CTD PMID:19783845 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 decreases expression EXP entacapone results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 2:151,357,592...151,381,340
Ensembl chr 2:151,357,592...151,380,046
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation EXP UGT1A1 protein results in increased glucuronidation of entacapone CTD PMID:15802387 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of entacapone CTD PMID:15802387 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300
JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases glucuronidation EXP UGT1A3 protein results in increased glucuronidation of entacapone CTD PMID:15802387 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300
JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of entacapone CTD PMID:15802387 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of entacapone CTD PMID:15802387 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300
JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
decreases glucuronidation
EXP UGT1A9 protein results in increased glucuronidation of entacapone
UGT1A9 protein mutant form results in decreased glucuronidation of entacapone
CTD PMID:15044611 PMID:15802387 PMID:16344532 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
JBrowse link
GSK343 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DICER1 dicer 1, ribonuclease III increases expression EXP GSK343 results in increased expression of DICER1 mRNA CTD PMID:25351418 NCBI chr14:95,086,228...95,158,010
Ensembl chr14:95,086,228...95,158,010
JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases activity EXP GSK343 results in decreased activity of EZH2 protein CTD PMID:23759589 PMID:24900432 NCBI chr 7:148,807,383...148,884,291
Ensembl chr 7:148,807,257...148,884,321
JBrowse link
LLY-507 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD36 CD36 molecule (CD36 blood group) multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of CD36 mRNA CTD PMID:29718165 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G IFNG interferon gamma multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of CD36 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MARCO mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MMP9 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MSR1 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of IL6 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of TNF mRNA CTD PMID:29718165 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL6 interleukin 6 multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of IL6 mRNA CTD PMID:29718165 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MARCO macrophage receptor with collagenous structure multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MARCO mRNA CTD PMID:29718165 NCBI chr 2:118,942,194...118,994,660
Ensembl chr 2:118,942,194...118,994,660
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MMP9 mRNA CTD PMID:29718165 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MSR1 macrophage scavenger receptor 1 multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MSR1 mRNA CTD PMID:29718165 NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490
JBrowse link
G SMYD2 SET and MYND domain containing 2 multiple interactions EXP LLY-507 binds to and results in decreased activity of SMYD2 protein CTD PMID:25825497 NCBI chr 1:214,281,159...214,337,131
Ensembl chr 1:214,281,102...214,337,131
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of TNF mRNA CTD PMID:29718165 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
N-ethylmaleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity EXP Ethylmaleimide results in decreased activity of ABCB1 protein CTD PMID:2900677 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) affects activity
multiple interactions
EXP Ethylmaleimide affects the activity of ABCC1 protein
Ethylmaleimide inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
CTD PMID:9096673 PMID:9334814 PMID:16101123 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
JBrowse link
G ACSL4 acyl-CoA synthetase long chain family member 4 decreases activity ISO Ethylmaleimide results in decreased activity of ACSL4 protein CTD PMID:11319222 NCBI chr  X:109,641,335...109,733,257
Ensembl chr  X:109,624,244...109,733,403
JBrowse link
G ALB albumin decreases transport ISO Ethylmaleimide results in decreased transport of ALB protein CTD PMID:15897811 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions EXP Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
JBrowse link
G ATP7A ATPase copper transporting alpha multiple interactions
increases glutathionylation
EXP Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,690...78,050,395
JBrowse link
G ATP8B1 ATPase phospholipid transporting 8B1 multiple interactions ISO Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines] CTD PMID:11584374 NCBI chr18:57,646,426...57,803,315
Ensembl chr18:57,646,426...57,803,315
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions EXP Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CHAT choline O-acetyltransferase decreases activity ISO Ethylmaleimide results in decreased activity of CHAT protein CTD PMID:3437937 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] CTD PMID:10820281 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G DUSP23 dual specificity phosphatase 23 multiple interactions EXP Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr 1:159,780,962...159,782,543
Ensembl chr 1:159,780,932...159,782,543
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Ethylmaleimide results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G GAD1 glutamate decarboxylase 1 decreases activity EXP Ethylmaleimide results in decreased activity of GAD1 protein CTD PMID:15836621 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
JBrowse link
G GAD2 glutamate decarboxylase 2 decreases activity EXP Ethylmaleimide results in decreased activity of GAD2 protein CTD PMID:15836621 NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558
JBrowse link
G HOXB13 homeobox B13 increases response to substance EXP HOXB13 protein results in increased susceptibility to Ethylmaleimide CTD PMID:24213000 NCBI chr17:48,724,763...48,728,750
Ensembl chr17:48,724,763...48,728,750
JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions EXP Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein] CTD PMID:22796344 NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553
JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 multiple interactions
decreases activity
ISO isocitric acid inhibits the reaction [Ethylmaleimide results in decreased activity of IDH1 protein]; NADP promotes the reaction [Ethylmaleimide results in decreased activity of IDH1 protein] CTD PMID:8486157 NCBI chr 2:208,236,227...208,255,071
Ensembl chr 2:208,236,229...208,266,074
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G LTBR lymphotoxin beta receptor multiple interactions EXP Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr12:6,375,160...6,391,566
Ensembl chr12:6,375,045...6,391,571
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MT3 metallothionein 3 increases alkylation EXP Ethylmaleimide results in increased alkylation of MT3 protein CTD PMID:12383939 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
JBrowse link
G OSM oncostatin M multiple interactions EXP Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr22:30,262,829...30,266,851
Ensembl chr22:30,262,829...30,266,851
JBrowse link
G PAH phenylalanine hydroxylase multiple interactions ISO Ethylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] CTD PMID:19367645 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
JBrowse link
G SENP1 SUMO specific peptidase 1 multiple interactions EXP Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein] CTD PMID:26060329 NCBI chr12:48,042,897...48,106,079
Ensembl chr12:48,039,784...48,106,079
JBrowse link
G SENP6 SUMO specific peptidase 6 multiple interactions EXP Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr 6:75,601,880...75,718,281
Ensembl chr 6:75,601,509...75,718,281
JBrowse link
G SLC12A5 solute carrier family 12 member 5 increases activity
multiple interactions
EXP Ethylmaleimide results in increased activity of SLC12A5 protein
Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]
CTD PMID:20086212 NCBI chr20:46,021,686...46,060,150
Ensembl chr20:46,021,690...46,060,150
JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions EXP Ethylmaleimide inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SP1 Sp1 transcription factor multiple interactions ISO
EXP
Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SUMO2 small ubiquitin like modifier 2 multiple interactions EXP Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]; Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr17:75,165,586...75,182,959
Ensembl chr17:75,165,586...75,182,959
JBrowse link
G TF transferrin decreases uptake ISO Ethylmaleimide results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G VDAC1 voltage dependent anion channel 1 affects binding ISO Ethylmaleimide binds to VDAC1 protein CTD PMID:20192921 NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975
JBrowse link
G VKORC1 vitamin K epoxide reductase complex subunit 1 decreases activity
multiple interactions
ISO Ethylmaleimide results in decreased activity of VKORC1 protein
Dithiothreitol promotes the reaction [Ethylmaleimide results in decreased activity of VKORC1 protein]
CTD PMID:2319331 NCBI chr16:31,090,854...31,094,797
Ensembl chr16:31,090,842...31,095,980
JBrowse link
pemetrexed term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC11 ATP binding cassette subfamily C member 11 decreases response to substance
affects response to substance
EXP ABCC11 mRNA results in decreased susceptibility to Pemetrexed; ABCC11 protein results in decreased susceptibility to Pemetrexed
ABCC11 gene SNP affects the susceptibility to Pemetrexed
CTD PMID:20718756 NCBI chr16:48,164,819...48,247,539
Ensembl chr16:48,165,773...48,247,568
JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 decreases response to substance EXP ABCC5 protein results in decreased susceptibility to Pemetrexed CTD PMID:15897250 NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939
JBrowse link
G ALK ALK receptor tyrosine kinase affects response to substance EXP ALK gene mutant form affects the susceptibility to Pemetrexed CTD PMID:21336183 NCBI chr 2:29,192,774...29,921,586
Ensembl chr 2:29,192,774...29,921,586
JBrowse link
G BBC3 BCL2 binding component 3 increases expression
multiple interactions
EXP Pemetrexed results in increased expression of BBC3 protein
xanthohumol promotes the reaction [Pemetrexed results in increased expression of BBC3 protein]
CTD PMID:35259468 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP [Cisplatin co-treated with Pemetrexed co-treated with Valproic Acid] results in decreased expression of BCL2 protein; [Cisplatin co-treated with Pemetrexed co-treated with vorinostat] results in decreased expression of BCL2 protein CTD PMID:19351772 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BID BH3 interacting domain death agonist multiple interactions EXP [Cisplatin co-treated with Pemetrexed] results in increased cleavage of BID protein CTD PMID:19351772 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G C3 complement C3 multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of C3 mRNA; [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of C3 protein CTD PMID:22975265 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of CCL2 mRNA CTD PMID:22975265 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
JBrowse link
G CCND1 cyclin D1 multiple interactions EXP [Cisplatin co-treated with Pemetrexed co-treated with Valproic Acid] results in decreased expression of CCND1 protein; [Cisplatin co-treated with Pemetrexed co-treated with vorinostat] results in decreased expression of CCND1 protein CTD PMID:19351772 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP [Cisplatin co-treated with Pemetrexed co-treated with Valproic Acid] results in increased expression of CDKN1A protein; [Cisplatin co-treated with Pemetrexed co-treated with vorinostat] results in increased expression of CDKN1A protein; [Cisplatin co-treated with Pemetrexed] results in increased expression of CDKN1A protein CTD PMID:19351772 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator decreases response to substance EXP CFLAR results in decreased susceptibility to Pemetrexed CTD PMID:21726997 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of CXCL8 mRNA; [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of CXCL8 protein CTD PMID:22975265 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP DDIT3 mutant form inhibits the reaction [Pemetrexed results in increased expression of TNFRSF10B] CTD PMID:21726997 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DHFR dihydrofolate reductase multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of DHFR mRNA CTD PMID:22975265 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983
JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression
EXP Pemetrexed inhibits the reaction [resveratrol results in increased stability of and results in increased expression of ERCC1 mRNA]; Pemetrexed inhibits the reaction [resveratrol results in increased stability of and results in increased expression of ERCC1 protein]
Pemetrexed results in decreased expression of ERCC1 mRNA; Pemetrexed results in decreased expression of ERCC1 protein
CTD PMID:23912706 NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,334...45,478,828
JBrowse link
G FAS Fas cell surface death receptor increases expression
multiple interactions
EXP Pemetrexed results in increased expression of FAS protein
TP53 protein affects the reaction [Pemetrexed results in increased expression of FAS protein]; TYMS protein inhibits the reaction [Pemetrexed results in increased expression of FAS protein]
CTD PMID:15161716 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FPGS folylpolyglutamate synthase increases response to substance EXP FPGS protein results in increased susceptibility to Pemetrexed CTD PMID:17575230 NCBI chr 9:127,802,858...127,814,506
Ensembl chr 9:127,794,597...127,814,494
JBrowse link
G GGH gamma-glutamyl hydrolase affects response to substance EXP GGH protein affects the susceptibility to Pemetrexed CTD PMID:17575230 NCBI chr 8:63,015,079...63,038,806
Ensembl chr 8:63,014,881...63,039,407
JBrowse link
G IFI30 IFI30 lysosomal thiol reductase multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IFI30 mRNA CTD PMID:22975265 NCBI chr19:18,173,813...18,178,117
Ensembl chr19:18,173,162...18,178,117
JBrowse link
G IL11 interleukin 11 multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL11 mRNA CTD PMID:22975265 NCBI chr19:55,364,382...55,370,463
Ensembl chr19:55,364,382...55,370,463
JBrowse link
G IL13RA2 interleukin 13 receptor subunit alpha 2 multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL13RA2 mRNA CTD PMID:22975265 NCBI chr  X:115,003,982...115,017,616
Ensembl chr  X:115,003,975...115,019,977
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL1A mRNA CTD PMID:22975265 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1RL1 interleukin 1 receptor like 1 multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL1RL1 mRNA CTD PMID:22975265 NCBI chr 2:102,311,563...102,352,356
Ensembl chr 2:102,311,502...102,352,037
JBrowse link
G IL32 interleukin 32 multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL32 mRNA CTD PMID:22975265 NCBI chr16:3,065,403...3,069,530
Ensembl chr16:3,065,297...3,082,192
JBrowse link
G IL33 interleukin 33 multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL33 mRNA CTD PMID:22975265 NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983
JBrowse link
G IL7R interleukin 7 receptor multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL7R mRNA CTD PMID:22975265 NCBI chr 5:35,856,891...35,879,603
Ensembl chr 5:35,852,695...35,879,603
JBrowse link
G KLRC1 killer cell lectin like receptor C1 multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of KLRC1 mRNA CTD PMID:22975265 NCBI chr12:10,442,264...10,454,685
Ensembl chr12:10,442,264...10,454,685
JBrowse link
G KRAS KRAS proto-oncogene, GTPase decreases expression
increases response to substance
EXP Pemetrexed results in decreased expression of KRAS mRNA; Pemetrexed results in decreased expression of KRAS mRNA mutant form; Pemetrexed results in decreased expression of KRAS protein
KRAS gene mutant form results in increased susceptibility to Pemetrexed
CTD PMID:24688052 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936
JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase increases response to substance EXP MTHFD2 protein results in increased susceptibility to Pemetrexed CTD PMID:24688052 NCBI chr 2:74,198,615...74,217,565
Ensembl chr 2:74,186,172...74,217,565
JBrowse link
G NPM1 nucleophosmin 1 decreases response to substance EXP NPM1 protein results in decreased susceptibility to Pemetrexed CTD PMID:24736981 NCBI chr 5:171,387,116...171,410,900
Ensembl chr 5:171,387,116...171,411,810
JBrowse link
G NRAS NRAS proto-oncogene, GTPase increases response to substance EXP NRAS gene mutant form results in increased susceptibility to Pemetrexed CTD PMID:24688052 NCBI chr 1:114,704,469...114,716,771
Ensembl chr 1:114,704,469...114,716,771
JBrowse link
G RBM17 RNA binding motif protein 17 decreases response to substance EXP RBM17 protein results in decreased susceptibility to Pemetrexed CTD PMID:16061639 NCBI chr10:6,089,034...6,117,447
Ensembl chr10:6,089,034...6,117,457
JBrowse link
G SLC19A1 solute carrier family 19 member 1 multiple interactions
increases response to substance
EXP Pemetrexed inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate]
SLC19A1 exon mutant form results in increased susceptibility to Pemetrexed
CTD PMID:16505119 PMID:21879757 NCBI chr21:45,502,517...45,563,025
Ensembl chr21:45,493,572...45,573,365
JBrowse link
G SLC46A1 solute carrier family 46 member 1 multiple interactions
increases activity
increases response to substance
EXP Pemetrexed inhibits the reaction [SLC46A1 protein results in increased uptake of Methotrexate]
Pemetrexed results in increased activity of SLC46A1 protein
SLC46A1 protein results in increased susceptibility to Pemetrexed
CTD PMID:21879757 NCBI chr17:28,394,642...28,406,592
Ensembl chr17:28,394,642...28,407,197
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of TNFAIP3 mRNA CTD PMID:22975265 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314
JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b multiple interactions
increases expression
EXP DDIT3 mutant form inhibits the reaction [Pemetrexed results in increased expression of TNFRSF10B] CTD PMID:21726997 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031
JBrowse link
G TNFRSF9 TNF receptor superfamily member 9 multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of TNFRSF9 mRNA CTD PMID:22975265 NCBI chr 1:7,915,871...7,940,839
Ensembl chr 1:7,915,871...7,943,165
JBrowse link
G TP53 tumor protein p53 multiple interactions
affects response to substance
EXP TP53 protein affects the reaction [Pemetrexed results in increased expression of FAS protein]
TP53 protein affects the susceptibility to Pemetrexed
CTD PMID:15161716 PMID:17339891 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
G TRAF1 TNF receptor associated factor 1 multiple interactions EXP [Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of TRAF1 mRNA CTD PMID:22975265 NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173
JBrowse link
G TYMP thymidine phosphorylase increases response to substance EXP TYMP protein results in increased susceptibility to Pemetrexed CTD PMID:17575230 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032
JBrowse link
G TYMS thymidylate synthetase decreases activity
multiple interactions
affects response to substance
EXP Pemetrexed results in decreased activity of TYMS protein
TYMS protein inhibits the reaction [Pemetrexed results in increased expression of FAS protein]
TYMS affects the susceptibility to Pemetrexed; TYMS protein affects the susceptibility to Pemetrexed
CTD PMID:15161716 PMID:17339891 PMID:21742432 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578
JBrowse link
S-adenosyl-L-homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHCY adenosylhomocysteinase increases hydrolysis EXP AHCY results in increased hydrolysis of S-Adenosylhomocysteine CTD PMID:26974671 NCBI chr20:34,231,981...34,311,836
Ensembl chr20:34,280,268...34,311,802
JBrowse link
G AHR aryl hydrocarbon receptor increases abundance
multiple interactions
ISO AHR protein results in increased abundance of S-Adenosylhomocysteine
PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine]
CTD PMID:29416063 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 multiple interactions EXP [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977
JBrowse link
G APP amyloid beta precursor protein increases expression
decreases methylation
multiple interactions
ISO S-Adenosylhomocysteine results in increased expression of APP protein
S-Adenosylhomocysteine results in decreased methylation of APP promoter
Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein
CTD PMID:19635394 PMID:22064374 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
JBrowse link
G ATP7B ATPase copper transporting beta increases abundance ISO ATP7B protein mutant form results in increased abundance of S-Adenosylhomocysteine CTD PMID:22945834 NCBI chr13:51,932,669...52,012,132
Ensembl chr13:51,930,436...52,012,125
JBrowse link
G BACE1 beta-secretase 1 increases expression ISO S-Adenosylhomocysteine results in increased expression of BACE1 protein CTD PMID:19635394 NCBI chr11:117,285,698...117,316,256
Ensembl chr11:117,285,232...117,316,259
JBrowse link
G CARM1 coactivator associated arginine methyltransferase 1 decreases activity EXP S-Adenosylhomocysteine results in decreased activity of CARM1 protein CTD PMID:33577917 NCBI chr19:10,871,553...10,923,075
Ensembl chr19:10,871,553...10,923,075
JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression EXP S-Adenosylhomocysteine results in decreased expression of COL1A1 mRNA CTD PMID:15983038 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL1A2 collagen type I alpha 2 chain decreases expression EXP S-Adenosylhomocysteine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G COMT catechol-O-methyltransferase decreases activity ISO S-Adenosylhomocysteine results in decreased activity of COMT protein CTD PMID:10064789 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975
JBrowse link
G DNMT1 DNA methyltransferase 1 decreases activity
multiple interactions
EXP
ISO
S-Adenosylhomocysteine results in decreased activity of DNMT1 protein
S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
CTD PMID:16037419 PMID:22064374 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286
JBrowse link
G FGF19 fibroblast growth factor 19 decreases abundance ISO FGF19 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022
JBrowse link
G HBB hemoglobin subunit beta multiple interactions EXP [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395
JBrowse link
G HMBS hydroxymethylbilane synthase multiple interactions EXP [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834
JBrowse link
G MMP2 matrix metallopeptidase 2 increases expression
multiple interactions
ISO S-Adenosylhomocysteine results in increased expression of MMP2 mRNA; S-Adenosylhomocysteine results in increased expression of MMP2 protein
S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]
U 0126 inhibits the reaction [S-Adenosylhomocysteine results in increased expression of MMP2 protein]
CTD PMID:19770485 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G NFKBIA NFKB inhibitor alpha decreases expression ISO S-Adenosylhomocysteine results in decreased expression of NFKBIA protein CTD PMID:19770485 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 decreases abundance ISO NR0B2 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase multiple interactions
decreases methylation
decreases expression
ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter]; S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
S-Adenosylhomocysteine results in decreased expression of OGG1 mRNA; S-Adenosylhomocysteine results in decreased expression of OGG1 protein
CTD PMID:22064374 NCBI chr 3:9,749,952...9,783,108
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase multiple interactions ISO PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine] CTD PMID:29416063 NCBI chr17:17,505,563...17,592,142
Ensembl chr17:17,505,563...17,591,708
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression EXP S-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRMT1 protein arginine methyltransferase 1 decreases activity EXP S-Adenosylhomocysteine results in decreased activity of PRMT1 protein CTD PMID:33577917 NCBI chr19:49,676,153...49,688,447
Ensembl chr19:49,675,786...49,689,029
JBrowse link
G PRMT5 protein arginine methyltransferase 5 decreases activity EXP S-Adenosylhomocysteine results in decreased activity of PRMT5 protein CTD PMID:33577917 NCBI chr14:22,920,529...22,929,376
Ensembl chr14:22,920,525...22,929,408
JBrowse link
G PRMT6 protein arginine methyltransferase 6 decreases activity EXP S-Adenosylhomocysteine results in decreased activity of PRMT6 protein CTD PMID:33577917 NCBI chr 1:107,056,674...107,059,294
Ensembl chr 1:107,056,674...107,067,636
JBrowse link
G PRMT7 protein arginine methyltransferase 7 decreases activity EXP S-Adenosylhomocysteine results in decreased activity of PRMT7 protein CTD PMID:33577917 NCBI chr16:68,311,019...68,360,870
Ensembl chr16:68,310,951...68,360,852
JBrowse link
G PSEN1 presenilin 1 multiple interactions
decreases methylation
increases expression
ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter]
S-Adenosylhomocysteine results in increased expression of PSEN1 protein
CTD PMID:19635394 NCBI chr14:73,136,417...73,223,691
Ensembl chr14:73,136,418...73,223,691
JBrowse link
G SLC19A1 solute carrier family 19 member 1 affects abundance ISO SLC19A1 protein affects the abundance of S-Adenosylhomocysteine CTD PMID:15705887 NCBI chr21:45,502,517...45,563,025
Ensembl chr21:45,493,572...45,573,365
JBrowse link
G SP1 Sp1 transcription factor multiple interactions ISO S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter] CTD PMID:19770485 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 decreases expression ISO S-Adenosylhomocysteine results in decreased expression of TIMP2 protein CTD PMID:19770485 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387
JBrowse link
tolcapone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AADAC arylacetamide deacetylase decreases expression ISO tolcapone results in decreased expression of AADAC mRNA CTD PMID:24136188 NCBI chr 3:151,814,116...151,828,488
Ensembl chr 3:151,814,073...151,828,488
JBrowse link
G AARS1 alanyl-tRNA synthetase 1 increases expression ISO Tolcapone results in increased expression of AARS1 mRNA CTD PMID:24136188 NCBI chr16:70,252,298...70,289,506
Ensembl chr16:70,251,983...70,289,707
JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity EXP tolcapone results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCD2 ATP binding cassette subfamily D member 2 affects binding ISO tolcapone binds to ABCD2 protein CTD PMID:19783845 NCBI chr12:39,531,025...39,619,803
Ensembl chr12:39,550,033...39,619,803
JBrowse link
G ABHD10 abhydrolase domain containing 10, depalmitoylase affects binding ISO tolcapone binds to ABHD10 protein CTD PMID:19783845 NCBI chr 3:111,979,026...111,993,368
Ensembl chr 3:111,979,010...111,993,368
JBrowse link
G ACAT2 acetyl-CoA acetyltransferase 2 increases expression ISO tolcapone results in increased expression of ACAT2 mRNA CTD PMID:24136188 NCBI chr 6:159,762,045...159,779,112
Ensembl chr 6:159,762,045...159,779,112
JBrowse link
G ACOX3 acyl-CoA oxidase 3, pristanoyl affects binding ISO tolcapone binds to ACOX3 protein CTD PMID:19783845 NCBI chr 4:8,355,305...8,440,723
Ensembl chr 4:8,366,282...8,440,723
JBrowse link
G ACSL1 acyl-CoA synthetase long chain family member 1 affects binding
decreases expression
ISO
EXP
tolcapone binds to ACSL1 protein
tolcapone results in decreased expression of ACSL1 mRNA; tolcapone results in decreased expression of ACSL1 protein
CTD PMID:19783845 PMID:29688484 NCBI chr 4:184,755,595...184,826,594
Ensembl chr 4:184,755,595...184,826,818
JBrowse link
G ACSL5 acyl-CoA synthetase long chain family member 5 decreases expression EXP tolcapone results in decreased expression of ACSL5 protein CTD PMID:29688484 NCBI chr10:112,374,116...112,428,376
Ensembl chr10:112,374,116...112,428,379
JBrowse link
G ACSS2 acyl-CoA synthetase short chain family member 2 increases expression ISO tolcapone results in increased expression of ACSS2 mRNA CTD PMID:24136188 NCBI chr20:34,874,989...34,927,959
Ensembl chr20:34,872,146...34,927,962
JBrowse link
G ACTA2 actin alpha 2, smooth muscle affects binding ISO tolcapone binds to ACTA2 protein CTD PMID:19783845 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339
JBrowse link
G ADPRHL1 ADP-ribosylhydrolase like 1 affects binding ISO tolcapone binds to ADPRHL1 protein CTD PMID:19783845 NCBI chr13:113,399,610...113,453,488
Ensembl chr13:113,399,611...113,453,488
JBrowse link
G AGA aspartylglucosaminidase decreases expression ISO tolcapone results in decreased expression of AGA mRNA CTD PMID:24136188 NCBI chr 4:177,430,774...177,442,437
Ensembl chr 4:177,430,774...177,442,437
JBrowse link
G AIF1 allograft inflammatory factor 1 decreases expression ISO tolcapone results in decreased expression of AIF1 mRNA CTD PMID:24136188 NCBI chr 6:31,615,234...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G AK2 adenylate kinase 2 affects binding ISO tolcapone binds to AK2 protein CTD PMID:19783845 NCBI chr 1:33,007,940...33,036,883
Ensembl chr 1:33,007,986...33,080,996
JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 affects binding ISO Tolcapone binds to AKR1C1 protein CTD PMID:19783845 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 decreases expression ISO tolcapone results in decreased expression of AKR1C3 mRNA CTD PMID:24136188 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G AKR1D1 aldo-keto reductase family 1 member D1 affects binding ISO tolcapone binds to AKR1D1 protein CTD PMID:19783845 NCBI chr 7:138,076,459...138,118,305
Ensembl chr 7:138,002,324...138,118,305
JBrowse link
G ALDH18A1 aldehyde dehydrogenase 18 family member A1 affects binding ISO tolcapone binds to ALDH18A1 protein CTD PMID:19783845 NCBI chr10:95,605,941...95,656,711
Ensembl chr10:95,605,941...95,656,711
JBrowse link
G ALDH1B1 aldehyde dehydrogenase 1 family member B1 affects binding ISO tolcapone binds to ALDH1B1 protein CTD PMID:19783845 NCBI chr 9:38,392,702...38,398,661
Ensembl chr 9:38,392,702...38,398,661
JBrowse link
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 increases expression ISO tolcapone results in increased expression of ALDH1L1 mRNA CTD PMID:24136188 NCBI chr 3:126,103,570...126,197,945
Ensembl chr 3:126,103,562...126,197,994
JBrowse link
G ALDH3A2 aldehyde dehydrogenase 3 family member A2 affects binding ISO tolcapone binds to ALDH3A2 protein CTD PMID:19783845 NCBI chr17:19,648,136...19,677,596
Ensembl chr17:19,648,136...19,685,760
JBrowse link
G ALG13 ALG13 UDP-N-acetylglucosaminyltransferase subunit decreases expression ISO Tolcapone results in decreased expression of ALG13 mRNA CTD PMID:24136188 NCBI chr  X:111,681,170...111,760,649
Ensembl chr  X:111,665,811...111,760,649
JBrowse link
G AMFR autocrine motility factor receptor increases expression ISO tolcapone results in increased expression of AMFR mRNA CTD PMID:24136188 NCBI chr16:56,361,452...56,425,545
Ensembl chr16:56,361,452...56,425,545
JBrowse link
G APMAP adipocyte plasma membrane associated protein affects binding ISO tolcapone binds to APMAP protein CTD PMID:19783845 NCBI chr20:24,962,925...24,992,751
Ensembl chr20:24,962,925...24,992,751
JBrowse link
G APOA1 apolipoprotein A1 affects binding ISO tolcapone binds to APOA1 protein CTD PMID:19783845 NCBI chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOB apolipoprotein B decreases secretion
decreases expression
EXP tolcapone results in decreased secretion of APOB protein alternative form
tolcapone results in decreased expression of APOB mRNA
CTD PMID:29688484 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G APOC2 apolipoprotein C2 decreases expression ISO tolcapone results in decreased expression of APOC2 mRNA CTD PMID:24136188 NCBI chr19:44,946,051...44,949,565
Ensembl chr19:44,946,035...44,949,565
JBrowse link
G APOE apolipoprotein E affects binding ISO tolcapone binds to APOE protein CTD PMID:19783845 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G APOOL apolipoprotein O like decreases expression ISO tolcapone results in decreased expression of APOOL mRNA CTD PMID:24136188 NCBI chr  X:85,003,877...85,093,315
Ensembl chr  X:85,003,877...85,093,315
JBrowse link
G ARF4 ARF GTPase 4 affects binding ISO tolcapone binds to ARF4 protein CTD PMID:19783845 NCBI chr 3:57,571,363...57,597,344
Ensembl chr 3:57,571,363...57,598,220
JBrowse link
G ARL1 ARF like GTPase 1 affects binding ISO tolcapone binds to ARL1 protein CTD PMID:19783845 NCBI chr12:101,393,116...101,407,820
Ensembl chr12:101,393,116...101,407,772
JBrowse link
G ATAD1 ATPase family AAA domain containing 1 affects binding ISO tolcapone binds to ATAD1 protein CTD PMID:19783845 NCBI chr10:87,751,512...87,841,361
Ensembl chr10:87,751,512...87,841,361
JBrowse link
G ATAD3A ATPase family AAA domain containing 3A affects binding ISO tolcapone binds to ATAD3A protein CTD PMID:19783845 NCBI chr 1:1,512,162...1,534,685
Ensembl chr 1:1,512,162...1,534,685
JBrowse link
G ATF5 activating transcription factor 5 increases expression ISO tolcapone results in increased expression of ATF5 mRNA CTD PMID:24136188 NCBI chr19:49,928,906...49,933,935
Ensembl chr19:49,928,702...49,933,935
JBrowse link
G ATP1B3 ATPase Na+/K+ transporting subunit beta 3 affects binding ISO tolcapone binds to ATP1B3 protein CTD PMID:19783845 NCBI chr 3:141,876,643...141,926,549
Ensembl chr 3:141,876,124...141,926,549
JBrowse link
G ATP5F1B ATP synthase F1 subunit beta affects binding ISO tolcapone binds to ATP5F1B protein CTD PMID:19783845 NCBI chr12:56,638,175...56,645,984
Ensembl chr12:56,638,175...56,645,984
JBrowse link
G ATP5F1C ATP synthase F1 subunit gamma affects binding ISO Tolcapone binds to ATP5F1C protein CTD PMID:19783845 NCBI chr10:7,788,177...7,807,801
Ensembl chr10:7,788,147...7,807,815
JBrowse link
G ATP5F1E ATP synthase F1 subunit epsilon decreases expression ISO tolcapone results in decreased expression of ATP5F1E mRNA CTD PMID:24136188 NCBI chr20:59,025,475...59,032,335
Ensembl chr20:59,025,475...59,032,345
JBrowse link
G ATP5ME ATP synthase membrane subunit e affects binding
decreases expression
ISO tolcapone binds to ATP5ME protein
tolcapone results in decreased expression of ATP5ME mRNA
CTD PMID:19783845 PMID:24136188 NCBI chr 4:672,436...674,276
Ensembl chr 4:672,436...674,330
JBrowse link
G ATP5MF ATP synthase membrane subunit f affects binding ISO tolcapone binds to ATP5MF protein CTD PMID:19783845 NCBI chr 7:99,458,195...99,466,167
Ensembl chr 7:99,448,475...99,466,186
JBrowse link
G ATP5MG ATP synthase membrane subunit g decreases expression
affects binding
ISO tolcapone results in decreased expression of ATP5MG mRNA
tolcapone binds to ATP5MG protein
CTD PMID:19783845 PMID:24136188 NCBI chr11:118,401,606...118,409,847
Ensembl chr11:118,401,346...118,433,278
JBrowse link
G ATP5MK ATP synthase membrane subunit k decreases expression ISO Tolcapone results in decreased expression of ATP5MK mRNA CTD PMID:24136188 NCBI chr10:103,389,050...103,396,475
Ensembl chr10:103,389,041...103,396,492
JBrowse link
G ATP5PF ATP synthase peripheral stalk subunit F6 decreases expression ISO tolcapone results in decreased expression of ATP5PF mRNA CTD PMID:24136188 NCBI chr21:25,724,500...25,735,653
Ensembl chr21:25,716,503...25,735,673
JBrowse link
G ATP5PO ATP synthase peripheral stalk subunit OSCP affects binding ISO tolcapone binds to ATP5PO protein CTD PMID:19783845 NCBI chr21:33,903,453...33,915,804
Ensembl chr21:33,903,453...33,915,814
JBrowse link
G AUH AU RNA binding methylglutaconyl-CoA hydratase affects binding ISO tolcapone binds to AUH protein CTD PMID:19783845 NCBI chr 9:91,213,823...91,361,918
Ensembl chr 9:91,213,815...91,361,918
JBrowse link
G BBOX1 gamma-butyrobetaine hydroxylase 1 decreases expression ISO tolcapone results in decreased expression of BBOX1 mRNA CTD PMID:24136188 NCBI chr11:27,040,815...27,127,809
Ensembl chr11:27,040,725...27,127,809
JBrowse link
G BCAM basal cell adhesion molecule (Lutheran blood group) affects binding ISO tolcapone binds to BCAM protein CTD PMID:19783845 NCBI chr19:44,809,059...44,821,421
Ensembl chr19:44,809,071...44,821,421
JBrowse link
G BCAP29 B cell receptor associated protein 29 decreases expression ISO tolcapone results in decreased expression of BCAP29 mRNA CTD PMID:24136188 NCBI chr 7:107,580,007...107,623,317
Ensembl chr 7:107,580,246...107,629,170
JBrowse link
G BCAS2 BCAS2 pre-mRNA processing factor decreases expression ISO tolcapone results in decreased expression of BCAS2 mRNA CTD PMID:24136188 NCBI chr 1:114,567,557...114,581,615
Ensembl chr 1:114,567,557...114,581,629
JBrowse link
G BLTP1 bridge-like lipid transfer protein family member 1 increases expression ISO Tolcapone results in increased expression of BLTP1 mRNA CTD PMID:24136188 NCBI chr 4:122,152,331...122,362,752
Ensembl chr 4:122,152,331...122,364,167
JBrowse link
G BMPER BMP binding endothelial regulator affects binding ISO tolcapone binds to BMPER protein CTD PMID:19783845 NCBI chr 7:33,904,915...34,156,427
Ensembl chr 7:33,904,308...34,156,427
JBrowse link
G BMS1 BMS1 ribosome biogenesis factor affects binding ISO tolcapone binds to BMS1 protein CTD PMID:19783845 NCBI chr10:42,782,795...42,834,937
Ensembl chr10:42,782,795...42,834,937
JBrowse link
G BPGM bisphosphoglycerate mutase decreases expression ISO tolcapone results in decreased expression of BPGM mRNA CTD PMID:24136188 NCBI chr 7:134,646,853...134,679,816
Ensembl chr 7:134,646,811...134,679,816
JBrowse link
G BTF3L4 basic transcription factor 3 like 4 decreases expression ISO tolcapone results in decreased expression of BTF3L4 mRNA CTD PMID:24136188 NCBI chr 1:52,056,295...52,090,716
Ensembl chr 1:52,056,199...52,090,716
JBrowse link
G C11orf71 chromosome 11 open reading frame 71 decreases expression ISO Tolcapone results in decreased expression of C8H11ORF71 mRNA CTD PMID:24136188 NCBI chr11:114,391,443...114,400,511
Ensembl chr11:114,391,443...114,400,511
JBrowse link
G C15orf61 chromosome 15 open reading frame 61 decreases expression ISO Tolcapone results in decreased expression of C8H15ORF61 mRNA CTD PMID:24136188 NCBI chr15:67,521,131...67,530,146
Ensembl chr15:67,521,131...67,530,146
JBrowse link
G C1D C1D nuclear receptor corepressor decreases expression ISO tolcapone results in decreased expression of C1D mRNA CTD PMID:24136188 NCBI chr 2:68,041,130...68,063,004
Ensembl chr 2:68,041,130...68,110,948
JBrowse link
G C1GALT1C1 C1GALT1 specific chaperone 1 decreases expression ISO tolcapone results in decreased expression of C1GALT1C1 mRNA CTD PMID:24136188 NCBI chr  X:120,625,674...120,630,054
Ensembl chr  X:120,625,674...120,630,054
JBrowse link
G C4B complement C4B (Chido/Rodgers blood group) increases expression ISO tolcapone results in increased expression of C4B mRNA CTD PMID:24136188 NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418
JBrowse link
G C5 complement C5 increases expression ISO tolcapone results in increased expression of C5 mRNA CTD PMID:24136188 NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195
JBrowse link
G C8A complement C8 alpha chain increases expression ISO tolcapone results in increased expression of C8A mRNA CTD PMID:24136188 NCBI chr 1:56,854,797...56,918,223
Ensembl chr 1:56,854,768...56,918,223
JBrowse link
G CBR4 carbonyl reductase 4 decreases expression ISO tolcapone results in decreased expression of CBR4 mRNA CTD PMID:24136188 NCBI chr 4:168,894,486...169,010,255
Ensembl chr 4:168,863,770...169,010,275
JBrowse link
G CCNL2 cyclin L2 increases expression ISO tolcapone results in increased expression of CCNL2 mRNA CTD PMID:24136188 NCBI chr 1:1,385,711...1,399,335
Ensembl chr 1:1,385,711...1,399,335
JBrowse link
G CCT7 chaperonin containing TCP1 subunit 7 affects binding ISO tolcapone binds to CCT7 protein CTD PMID:19783845 NCBI chr 2:73,234,308...73,253,005
Ensembl chr 2:73,233,420...73,253,021
JBrowse link
G CD36 CD36 molecule (CD36 blood group) increases expression EXP tolcapone results in increased expression of CD36 mRNA CTD PMID:29688484 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CFB complement factor B increases expression ISO tolcapone results in increased expression of CFB mRNA CTD PMID:24136188 NCBI chr 6:31,946,095...31,952,084
Ensembl chr 6:31,945,650...31,952,086
JBrowse link
G CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 decreases expression ISO tolcapone results in decreased expression of CHCHD1 mRNA CTD PMID:24136188 NCBI chr10:73,782,048...73,783,652
Ensembl chr10:73,782,047...73,783,652
JBrowse link
G CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 decreases expression ISO tolcapone results in decreased expression of CHCHD7 mRNA CTD PMID:24136188 NCBI chr 8:56,211,789...56,218,809
Ensembl chr 8:56,211,686...56,218,809
JBrowse link
G CHRAC1 chromatin accessibility complex subunit 1 decreases expression ISO tolcapone results in decreased expression of CHRAC1 mRNA CTD PMID:24136188 NCBI chr 8:140,511,322...140,517,154
Ensembl chr 8:140,511,311...140,517,154
JBrowse link
G CHURC1 churchill domain containing 1 decreases expression ISO tolcapone results in decreased expression of CHURC1 mRNA CTD PMID:24136188 NCBI chr14:64,914,455...64,935,368
Ensembl chr14:64,914,361...64,944,591
JBrowse link
G CIAO2A cytosolic iron-sulfur assembly component 2A decreases expression ISO tolcapone results in decreased expression of CIAO2A mRNA CTD PMID:24136188 NCBI chr15:64,072,565...64,093,838
Ensembl chr15:64,072,565...64,094,262
JBrowse link
G CIDEA cell death inducing DFFA like effector a increases expression EXP tolcapone results in increased expression of CIDEA mRNA CTD PMID:29688484 NCBI chr18:12,254,361...12,277,595
Ensembl chr18:12,254,361...12,277,595
JBrowse link
G CISD1 CDGSH iron sulfur domain 1 affects binding ISO tolcapone binds to CISD1 protein CTD PMID:19783845 NCBI chr10:58,269,162...58,289,586
Ensembl chr10:58,269,162...58,289,586
JBrowse link
G CLEC4A C-type lectin domain family 4 member A decreases expression ISO Tolcapone results in decreased expression of CLEC4A3 mRNA CTD PMID:24136188 NCBI chr12:8,102,907...8,138,607
Ensembl chr12:8,123,617...8,138,607
JBrowse link
G CLTC clathrin heavy chain affects binding ISO tolcapone binds to CLTC protein CTD PMID:19783845 NCBI chr17:59,619,895...59,696,956
Ensembl chr17:59,619,680...59,696,956
JBrowse link
G CNIH4 cornichon family member 4 decreases expression ISO tolcapone results in decreased expression of CNIH4 mRNA CTD PMID:24136188 NCBI chr 1:224,356,803...224,379,452
Ensembl chr 1:224,356,858...224,379,459
JBrowse link
G COMMD6 COMM domain containing 6 decreases expression ISO tolcapone results in decreased expression of COMMD6 mRNA CTD PMID:24136188 NCBI chr13:75,525,214...75,549,439
Ensembl chr13:75,525,214...75,549,439
JBrowse link
G COMT catechol-O-methyltransferase decreases activity
multiple interactions
increases methylation
affects binding
ISO
EXP
tolcapone results in decreased activity of COMT protein
[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]; [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine; tolcapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]
COMT protein results in increased methylation of tolcapone
tolcapone binds to COMT protein
CTD PMID:2089102 PMID:7566641 PMID:7768073 PMID:8821542 PMID:9333106 More... NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975
JBrowse link
G COPG1 COPI coat complex subunit gamma 1 affects binding ISO tolcapone binds to COPG1 protein CTD PMID:19783845 NCBI chr 3:129,249,606...129,277,773
Ensembl chr 3:129,249,606...129,277,773
JBrowse link
G COPG2 COPI coat complex subunit gamma 2 decreases expression ISO tolcapone results in decreased expression of COPG2 mRNA CTD PMID:24136188 NCBI chr 7:130,506,238...130,668,748
Ensembl chr 7:130,506,238...130,668,748
JBrowse link
G COQ10A coenzyme Q10A decreases expression ISO tolcapone results in decreased expression of COQ10A mRNA CTD PMID:24136188 NCBI chr12:56,266,942...56,270,966
Ensembl chr12:56,266,890...56,270,966
JBrowse link
G COQ3 coenzyme Q3, methyltransferase decreases expression ISO tolcapone results in decreased expression of COQ3 mRNA CTD PMID:24136188 NCBI chr 6:99,369,401...99,394,195
Ensembl chr 6:99,369,401...99,394,195
JBrowse link
G COX6C cytochrome c oxidase subunit 6C affects binding
decreases expression
ISO tolcapone binds to COX6C protein
tolcapone results in decreased expression of COX6C mRNA
CTD PMID:19783845 PMID:24136188 NCBI chr 8:99,877,865...99,893,707
Ensembl chr 8:99,873,200...99,893,707
JBrowse link
G COX7A2 cytochrome c oxidase subunit 7A2 decreases expression ISO tolcapone results in decreased expression of COX7A2 mRNA CTD PMID:24136188 NCBI chr 6:75,237,675...75,250,298
Ensembl chr 6:75,237,675...75,250,323
JBrowse link
G COX7B cytochrome c oxidase subunit 7B decreases expression ISO tolcapone results in decreased expression of COX7B mRNA CTD PMID:24136188 NCBI chr  X:77,899,468...77,907,376
Ensembl chr  X:77,899,440...77,907,376
JBrowse link
G CP ceruloplasmin increases expression ISO tolcapone results in increased expression of CP mRNA CTD PMID:24136188 NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829
JBrowse link
G CREM cAMP responsive element modulator decreases expression ISO tolcapone results in decreased expression of CREM mRNA CTD PMID:24136188 NCBI chr10:35,126,846...35,212,958
Ensembl chr10:35,126,791...35,212,958
JBrowse link
G CRIP2 cysteine rich protein 2 increases expression ISO tolcapone results in increased expression of CRIP2 mRNA CTD PMID:24136188 NCBI chr14:105,472,945...105,480,170
Ensembl chr14:105,472,962...105,480,162
JBrowse link
G CSE1L chromosome segregation 1 like affects binding ISO tolcapone binds to CSE1L protein CTD PMID:19783845 NCBI chr20:49,046,312...49,096,949
Ensembl chr20:49,046,246...49,096,960
JBrowse link
G CSTB cystatin B decreases expression ISO tolcapone results in decreased expression of CSTB mRNA CTD PMID:24136188 NCBI chr21:43,773,950...43,776,308
Ensembl chr21:43,772,511...43,776,330
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Tolcapone results in increased expression of CXCL8 mRNA CTD PMID:32816093 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CYC1 cytochrome c1 affects binding ISO tolcapone binds to CYC1 protein CTD PMID:19783845 NCBI chr 8:144,095,076...144,097,525
Ensembl chr 8:144,095,039...144,097,525
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity
ISO
EXP
tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Tolcapone results in decreased activity of CYP1A1 protein
CTD PMID:18493746 PMID:33814510 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions
increases expression
ISO
EXP
tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
tolcapone results in increased expression of CYP1A2 mRNA
CTD PMID:18493746 PMID:24136188 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP Tolcapone results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases response to substance EXP CYP3A4 protein results in increased susceptibility to tolcapone CTD PMID:21540358 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 increases expression ISO tolcapone results in increased expression of CYP51 mRNA CTD PMID:24136188 NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803
JBrowse link
G DAP death associated protein increases expression ISO tolcapone results in increased expression of DAP mRNA CTD PMID:24136188 NCBI chr 5:10,679,230...10,761,234
Ensembl chr 5:10,679,230...10,761,234
JBrowse link
G DCTD dCMP deaminase affects binding ISO tolcapone binds to DCTD protein CTD PMID:19783845 NCBI chr 4:182,890,091...182,917,611
Ensembl chr 4:182,890,060...182,917,936
JBrowse link
G DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit affects binding ISO tolcapone binds to DDOST protein CTD PMID:19783845 NCBI chr 1:20,651,777...20,661,369
Ensembl chr 1:20,651,767...20,661,544
JBrowse link
G DDX18 DEAD-box helicase 18 affects binding ISO tolcapone binds to DDX18 protein CTD PMID:19783845 NCBI chr 2:117,814,691...117,832,377
Ensembl chr 2:117,814,691...117,832,377
JBrowse link
G DHCR24 24-dehydrocholesterol reductase affects binding
increases expression
ISO tolcapone binds to DHCR24 protein
tolcapone results in increased expression of DHCR24 mRNA
CTD PMID:19783845 PMID:24136188 NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195
JBrowse link
G DHCR7 7-dehydrocholesterol reductase affects binding ISO tolcapone binds to DHCR7 protein CTD PMID:19783845 NCBI chr11:71,427,287...71,449,043
Ensembl chr11:71,428,193...71,452,868
JBrowse link
G DMAC1 distal membrane arm assembly component 1 decreases expression ISO tolcapone results in decreased expression of DMAC1 mRNA CTD PMID:24136188 NCBI chr 9:7,796,500...7,799,778
Ensembl chr 9:7,796,500...7,888,380
JBrowse link
G DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 decreases expression ISO tolcapone results in decreased expression of DNAJC15 mRNA CTD PMID:24136188 NCBI chr13:43,023,586...43,114,213
Ensembl chr13:43,023,203...43,114,213
JBrowse link
G DOCK11 dedicator of cytokinesis 11 decreases expression ISO tolcapone results in decreased expression of DOCK11 mRNA CTD PMID:24136188 NCBI chr  X:118,495,815...118,686,147
Ensembl chr  X:118,495,815...118,686,163
JBrowse link
G DPM3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory decreases expression ISO tolcapone results in decreased expression of DPM3 mRNA CTD PMID:24136188 NCBI chr 1:155,139,891...155,140,531
Ensembl chr 1:155,139,891...155,140,595
JBrowse link
G DPY30 dpy-30 histone methyltransferase complex regulatory subunit decreases expression ISO tolcapone results in decreased expression of DPY30 mRNA CTD PMID:24136188 NCBI chr 2:32,011,649...32,039,835
Ensembl chr 2:31,867,809...32,039,805
JBrowse link
G DTYMK deoxythymidylate kinase decreases expression ISO tolcapone results in decreased expression of DTYMK mRNA CTD PMID:24136188 NCBI chr 2:241,675,747...241,686,815
Ensembl chr 2:241,675,747...241,686,944
JBrowse link
G DYNLL1 dynein light chain LC8-type 1 decreases expression ISO tolcapone results in decreased expression of DYNLL1 mRNA CTD PMID:24136188 NCBI chr12:120,469,842...120,498,493
Ensembl chr12:120,469,850...120,498,493
JBrowse link
G DYNLT3 dynein light chain Tctex-type 3 decreases expression ISO tolcapone results in decreased expression of DYNLT3 mRNA CTD PMID:24136188 NCBI chr  X:37,838,836...37,847,571
Ensembl chr  X:37,836,757...37,847,571
JBrowse link
G EBP EBP cholestenol delta-isomerase increases expression ISO tolcapone results in increased expression of EBP mRNA CTD PMID:24136188 NCBI chr  X:48,521,808...48,528,716
Ensembl chr  X:48,521,799...48,528,716
JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 affects binding ISO tolcapone binds to ECHS1 protein CTD PMID:19783845 NCBI chr10:133,362,485...133,373,354
Ensembl chr10:133,362,485...133,373,354
JBrowse link
G ELOC elongin C decreases expression ISO tolcapone results in decreased expression of ELOC mRNA CTD PMID:24136188 NCBI chr 8:73,945,119...73,972,287
Ensembl chr 8:73,939,169...73,972,307
JBrowse link
G EREG epiregulin decreases expression EXP Tolcapone results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749
JBrowse link
G F5 coagulation factor V increases expression ISO tolcapone results in increased expression of F5 mRNA CTD PMID:24136188 NCBI chr 1:169,511,951...169,586,481
Ensembl chr 1:169,511,951...169,586,588
JBrowse link
G FAM162A family with sequence similarity 162 member A affects binding ISO tolcapone binds to FAM162A protein CTD PMID:19783845 NCBI chr 3:122,384,182...122,412,334
Ensembl chr 3:122,384,161...122,412,334
JBrowse link
G FBLL1 fibrillarin like 1 affects binding ISO tolcapone binds to FBLL1 protein CTD PMID:19783845 NCBI chr 5:168,529,305...168,530,634
Ensembl chr 5:168,529,305...168,530,634
JBrowse link
G FCF1 FCF1 rRNA-processing protein decreases expression ISO tolcapone results in decreased expression of FCF1 mRNA CTD PMID:24136188 NCBI chr14:74,713,144...74,738,620
Ensembl chr14:74,713,144...74,738,620
JBrowse link
G FGA fibrinogen alpha chain affects binding ISO tolcapone binds to FGA protein CTD PMID:19783845 NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,126...154,590,742
JBrowse link
G FMC1 formation of mitochondrial complex V assembly factor 1 homolog decreases expression ISO tolcapone results in decreased expression of FMC1 mRNA CTD PMID:24136188 NCBI chr 7:139,340,472...139,346,328
Ensembl chr 7:139,339,457...139,346,328
JBrowse link
G GCDH glutaryl-CoA dehydrogenase affects binding ISO tolcapone binds to GCDH protein CTD PMID:19783845 NCBI chr19:12,891,129...12,899,999
Ensembl chr19:12,891,128...12,915,126
JBrowse link
G GLG1 golgi glycoprotein 1 affects binding ISO tolcapone binds to GLG1 protein CTD PMID:19783845 NCBI chr16:74,447,440...74,607,114
Ensembl chr16:74,447,427...74,607,144
JBrowse link
G GMFG glia maturation factor gamma decreases expression ISO tolcapone results in decreased expression of GMFG mRNA CTD PMID:24136188 NCBI chr19:39,328,359...39,336,043
Ensembl chr19:39,328,353...39,342,372
JBrowse link
G GNG10 G protein subunit gamma 10 decreases expression ISO tolcapone results in decreased expression of GNG10 mRNA CTD PMID:24136188 NCBI chr 9:111,661,605...111,670,226
Ensembl chr 9:111,661,605...111,670,226
JBrowse link
G GNG5 G protein subunit gamma 5 decreases expression ISO tolcapone results in decreased expression of GNG5 mRNA CTD PMID:24136188 NCBI chr 1:84,498,325...84,506,581
Ensembl chr 1:84,498,323...84,506,581
JBrowse link
G GPC3 glypican 3 affects binding ISO tolcapone binds to GPC3 protein CTD PMID:19783845 NCBI chr  X:133,535,745...133,985,594
Ensembl chr  X:133,535,745...133,987,100
JBrowse link
G GTF2H5 general transcription factor IIH subunit 5 decreases expression ISO tolcapone results in decreased expression of GTF2H5 mRNA CTD PMID:24136188 NCBI chr 6:158,168,350...158,199,344
Ensembl chr 6:158,168,350...158,199,344
JBrowse link
G H2AZ2 H2A.Z variant histone 2 affects binding ISO Tolcapone binds to H2AZ2 protein CTD PMID:19783845 NCBI chr 7:44,826,889...44,848,126
Ensembl chr 7:44,826,791...44,848,087
JBrowse link
G H4C9 H4 clustered histone 9 decreases expression ISO Tolcapone results in decreased expression of HIST1H4B mRNA CTD PMID:24136188 NCBI chr 6:27,139,282...27,139,678
Ensembl chr 6:27,139,282...27,140,640
JBrowse link
G HBB hemoglobin subunit beta affects binding ISO tolcapone binds to HBB protein CTD PMID:19783845 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395
JBrowse link
G HIGD1A HIG1 hypoxia inducible domain family member 1A decreases expression ISO tolcapone results in decreased expression of HIGD1A mRNA CTD PMID:24136188 NCBI chr 3:42,782,908...42,804,490
Ensembl chr 3:42,782,908...42,804,490
JBrowse link
G HINT3 histidine triad nucleotide binding protein 3 decreases expression ISO tolcapone results in decreased expression of HINT3 mRNA CTD PMID:24136188 NCBI chr 6:125,956,770...125,980,244
Ensembl chr 6:125,956,770...125,980,244
JBrowse link
G HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 affects binding ISO tolcapone binds to HNRNPH1 protein CTD PMID:19783845 NCBI chr 5:179,614,178...179,634,784
Ensembl chr 5:179,614,178...179,634,784
JBrowse link
G HSD17B11 hydroxysteroid 17-beta dehydrogenase 11 affects binding ISO tolcapone binds to HSD17B11 protein CTD PMID:19783845 NCBI chr 4:87,336,515...87,391,188
Ensembl chr 4:87,336,515...87,391,188
JBrowse link
G HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 affects binding ISO tolcapone binds to HSD17B12 protein CTD PMID:19783845 NCBI chr11:43,556,721...43,856,615
Ensembl chr11:43,680,680...43,856,617
JBrowse link
G HSD17B13 hydroxysteroid 17-beta dehydrogenase 13 affects binding ISO tolcapone binds to HSD17B13 protein CTD PMID:19783845 NCBI chr 4:87,303,794...87,322,882
Ensembl chr 4:87,303,789...87,322,886
JBrowse link
G HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 affects binding ISO tolcapone binds to HSD17B4 protein CTD PMID:19783845 NCBI chr 5:119,452,497...119,542,332
Ensembl chr 5:119,452,465...119,637,199
JBrowse link
G HSDL2 hydroxysteroid dehydrogenase like 2 increases expression ISO tolcapone results in increased expression of HSDL2 mRNA CTD PMID:24136188 NCBI chr 9:112,380,108...112,472,405
Ensembl chr 9:112,380,080...112,472,405
JBrowse link
G IFTAP intraflagellar transport associated protein decreases expression ISO Tolcapone results in decreased expression of IFTAP mRNA CTD PMID:24136188 NCBI chr11:36,594,502...36,659,272
Ensembl chr11:36,594,369...36,675,695
JBrowse link
G IGFBP1 insulin like growth factor binding protein 1 increases expression ISO tolcapone results in increased expression of IGFBP1 mRNA CTD PMID:24136188 NCBI chr 7:45,888,488...45,893,660
Ensembl chr 7:45,888,360...45,893,660
JBrowse link
G IL24 interleukin 24 decreases expression EXP Tolcapone results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr 1:206,897,443...206,904,139
Ensembl chr 1:206,897,443...206,904,139
JBrowse link
G IPO7 importin 7 affects binding ISO tolcapone binds to IPO7 protein CTD PMID:19783845 NCBI chr11:9,384,652...9,448,127
Ensembl chr11:9,384,652...9,448,127
JBrowse link
G ITM2A integral membrane protein 2A affects binding ISO tolcapone binds to ITM2A protein CTD PMID:19783845 NCBI chr  X:79,360,384...79,367,334
Ensembl chr  X:79,360,384...79,367,667
JBrowse link
G JAGN1 jagunal homolog 1 affects binding ISO tolcapone binds to JAGN1 protein CTD PMID:19783845 NCBI chr 3:9,890,610...9,894,349
Ensembl chr 3:9,890,574...9,894,349
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP tolcapone results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KGD4 alpha-ketoglutarate dehydrogenase subunit 4 decreases expression ISO Tolcapone results in decreased expression of KGD4 mRNA CTD PMID:24136188 NCBI chr 5:69,217,760...69,230,158
Ensembl chr 5:69,217,760...69,230,158
JBrowse link
G KIAA1143 KIAA1143 decreases expression ISO tolcapone results in decreased expression of RGD1311745 mRNA CTD PMID:24136188 NCBI chr 3:44,748,744...44,761,619
Ensembl chr 3:44,737,661...44,761,619
JBrowse link
G KNG1 kininogen 1 increases expression ISO Tolcapone results in increased expression of KNG1 mRNA CTD PMID:24136188 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410
JBrowse link
G LAGE3 L antigen family member 3 decreases expression ISO tolcapone results in decreased expression of LAGE3 mRNA CTD PMID:24136188 NCBI chr  X:154,477,775...154,479,281
Ensembl chr  X:154,477,775...154,479,281
JBrowse link
G LBP lipopolysaccharide binding protein increases expression ISO tolcapone results in increased expression of LBP mRNA CTD PMID:24136188 NCBI chr20:38,346,482...38,377,013
Ensembl chr20:38,346,482...38,377,013
JBrowse link
G LRRC59 leucine rich repeat containing 59 affects binding ISO tolcapone binds to LRRC59 protein CTD PMID:19783845 NCBI chr17:50,381,238...50,397,523
Ensembl chr17:50,375,059...50,397,523
JBrowse link
G LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO tolcapone results in decreased expression of LSM3 mRNA CTD PMID:24136188 NCBI chr 3:14,178,817...14,201,122
Ensembl chr 3:14,178,817...14,201,122
JBrowse link
G LSM5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO tolcapone results in decreased expression of LSM5 mRNA CTD PMID:24136188 NCBI chr 7:32,485,338...32,495,283
Ensembl chr 7:32,485,338...32,495,283
JBrowse link
G LSM7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO tolcapone results in decreased expression of LSM7 mRNA CTD PMID:24136188 NCBI chr19:2,321,521...2,328,586
Ensembl chr19:2,321,520...2,328,611
JBrowse link
G MAGOH mago homolog, exon junction complex subunit decreases expression ISO tolcapone results in decreased expression of MAGOH mRNA CTD PMID:24136188 NCBI chr 1:53,226,900...53,238,518
Ensembl chr 1:53,226,900...53,238,518
JBrowse link
G MASP1 MBL associated serine protease 1 increases expression ISO tolcapone results in increased expression of MASP1 mRNA CTD PMID:24136188 NCBI chr 3:187,217,282...187,291,737
Ensembl chr 3:187,217,282...187,291,980
JBrowse link
G MATR3 matrin 3 decreases expression ISO tolcapone results in decreased expression of MATR3 mRNA CTD PMID:24136188 NCBI chr 5:139,274,101...139,331,677
Ensembl chr 5:139,273,752...139,331,671
Ensembl chr 5:139,273,752...139,331,671
JBrowse link
G MCEE methylmalonyl-CoA epimerase decreases expression ISO tolcapone results in decreased expression of MCEE mRNA CTD PMID:24136188 NCBI chr 2:71,109,687...71,130,229
Ensembl chr 2:71,109,684...71,130,239
JBrowse link
G MCTS1 MCTS1 re-initiation and release factor decreases expression ISO tolcapone results in decreased expression of MCTS1 mRNA CTD PMID:24136188 NCBI chr  X:120,604,101...120,621,159
Ensembl chr  X:120,594,010...120,621,159
JBrowse link
G MED21 mediator complex subunit 21 decreases expression ISO tolcapone results in decreased expression of MED21 mRNA CTD PMID:24136188 NCBI chr12:27,022,558...27,038,951
Ensembl chr12:27,022,546...27,066,343
JBrowse link
G MED28 mediator complex subunit 28 decreases expression ISO tolcapone results in decreased expression of MED28 mRNA CTD PMID:24136188 NCBI chr 4:17,614,641...17,634,105
Ensembl chr 4:17,614,641...17,634,105
JBrowse link
G MED31 mediator complex subunit 31 decreases expression ISO tolcapone results in decreased expression of MED31 mRNA CTD PMID:24136188 NCBI chr17:6,643,311...6,651,605
Ensembl chr17:6,643,311...6,651,634
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase increases expression EXP Tolcapone results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377
JBrowse link
G METTL5 methyltransferase 5, N6-adenosine decreases expression ISO tolcapone results in decreased expression of METTL5 mRNA CTD PMID:24136188 NCBI chr 2:169,811,757...169,824,905
Ensembl chr 2:169,810,081...169,824,931
JBrowse link
G MFSD5 major facilitator superfamily domain containing 5 decreases expression ISO tolcapone results in decreased expression of MFSD5 mRNA CTD PMID:24136188 NCBI chr12:53,251,197...53,254,406
Ensembl chr12:53,251,251...53,254,406
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 affects binding ISO tolcapone binds to MGST1 protein CTD PMID:19783845 NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MIA3 MIA SH3 domain ER export factor 3 decreases expression ISO tolcapone results in decreased expression of MIA3 mRNA CTD PMID:24136188 NCBI chr 1:222,618,097...222,668,007
Ensembl chr 1:222,618,097...222,668,007
JBrowse link
G MKKS MKKS centrosomal shuttling protein decreases expression ISO tolcapone results in decreased expression of MKKS mRNA CTD PMID:24136188 NCBI chr20:10,401,009...10,434,222
Ensembl chr20:10,401,009...10,434,222
JBrowse link
G MKRN1 makorin ring finger protein 1 decreases expression ISO tolcapone results in decreased expression of MKRN1 mRNA CTD PMID:24136188 NCBI chr 7:140,453,033...140,479,569
Ensembl chr 7:140,453,033...140,479,536
JBrowse link
G MMADHC metabolism of cobalamin associated D decreases expression ISO tolcapone results in decreased expression of MMADHC mRNA CTD PMID:24136188 NCBI chr 2:149,569,637...149,587,775
Ensembl chr 2:149,569,637...149,587,778
JBrowse link
G MRPL1 mitochondrial ribosomal protein L1 decreases expression ISO tolcapone results in decreased expression of MRPL1 mRNA CTD PMID:24136188 NCBI chr 4:77,862,830...77,952,785
Ensembl chr 4:77,862,830...77,952,785
JBrowse link
G MRPL13 mitochondrial ribosomal protein L13 decreases expression ISO tolcapone results in decreased expression of MRPL13 mRNA CTD PMID:24136188 NCBI chr 8:120,395,437...120,445,150
Ensembl chr 8:120,380,761...120,445,402
JBrowse link
G MRPL14 mitochondrial ribosomal protein L14 decreases expression ISO tolcapone results in decreased expression of MRPL14 mRNA CTD PMID:24136188 NCBI chr 6:44,113,451...44,127,452
Ensembl chr 6:44,113,451...44,127,452
JBrowse link
G MRPL18 mitochondrial ribosomal protein L18 decreases expression ISO tolcapone results in decreased expression of MRPL18 mRNA CTD PMID:24136188 NCBI chr 6:159,789,812...159,798,429
Ensembl chr 6:159,789,812...159,798,436
JBrowse link
G MRPL20 mitochondrial ribosomal protein L20 decreases expression ISO tolcapone results in decreased expression of MRPL20 mRNA CTD PMID:24136188 NCBI chr 1:1,401,909...1,407,293
Ensembl chr 1:1,401,909...1,407,293
JBrowse link
G MRPL22 mitochondrial ribosomal protein L22 decreases expression ISO tolcapone results in decreased expression of MRPL22 mRNA CTD PMID:24136188 NCBI chr 5:154,941,073...154,969,411
Ensembl chr 5:154,941,073...154,969,411
JBrowse link
G MRPL23 mitochondrial ribosomal protein L23 decreases expression ISO tolcapone results in decreased expression of MRPL23 mRNA CTD PMID:24136188 NCBI chr11:1,947,332...2,014,944
Ensembl chr11:1,947,278...1,984,522
JBrowse link
G MRPL30 mitochondrial ribosomal protein L30 decreases expression ISO tolcapone results in decreased expression of MRPL30 mRNA CTD PMID:24136188 NCBI chr 2:99,181,184...99,199,561
Ensembl chr 2:99,181,152...99,199,561
JBrowse link
G MRPL32 mitochondrial ribosomal protein L32 decreases expression ISO tolcapone results in decreased expression of MRPL32 mRNA CTD PMID:24136188 NCBI chr 7:42,932,376...42,937,857
Ensembl chr 7:42,932,376...42,948,958
JBrowse link
G MRPL36 mitochondrial ribosomal protein L36 decreases expression ISO tolcapone results in decreased expression of MRPL36 mRNA CTD PMID:24136188 NCBI chr 5:1,798,385...1,801,434
Ensembl chr 5:1,798,385...1,801,366
JBrowse link
G MRPL40 mitochondrial ribosomal protein L40 decreases expression ISO tolcapone results in decreased expression of MRPL40 mRNA CTD PMID:24136188 NCBI chr22:19,432,545...19,436,075
Ensembl chr22:19,432,545...19,436,075
JBrowse link
G MRPL53 mitochondrial ribosomal protein L53 decreases expression ISO tolcapone results in decreased expression of MRPL53 mRNA CTD PMID:24136188 NCBI chr 2:74,471,982...74,472,680
Ensembl chr 2:74,471,982...74,472,687
JBrowse link
G MRPS14 mitochondrial ribosomal protein S14 decreases expression ISO tolcapone results in decreased expression of MRPS14 mRNA CTD PMID:24136188 NCBI chr 1:175,012,958...175,023,425
Ensembl chr 1:175,010,789...175,023,425
JBrowse link
G MRPS18C mitochondrial ribosomal protein S18C decreases expression ISO tolcapone results in decreased expression of MRPS18C mRNA CTD PMID:24136188 NCBI chr 4:83,456,058...83,462,298
Ensembl chr 4:83,455,932...83,469,735
JBrowse link
G MRPS24 mitochondrial ribosomal protein S24 decreases expression ISO tolcapone results in decreased expression of MRPS24 mRNA CTD PMID:24136188 NCBI chr 7:43,866,558...43,869,517
Ensembl chr 7:43,866,558...43,869,893
JBrowse link
G MRPS33 mitochondrial ribosomal protein S33 decreases expression ISO tolcapone results in decreased expression of MRPS33 mRNA CTD PMID:24136188 NCBI chr 7:141,002,610...141,014,952
Ensembl chr 7:141,002,610...141,015,228
JBrowse link
G MTAP methylthioadenosine phosphorylase affects binding ISO tolcapone binds to MTAP protein CTD PMID:19783845 NCBI chr 9:21,802,636...21,941,115
Ensembl chr 9:21,802,636...21,937,651
JBrowse link
G MTTP microsomal triglyceride transfer protein increases expression EXP tolcapone results in increased expression of MTTP protein CTD PMID:29688484 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,564,081...99,623,997
JBrowse link
G MVK mevalonate kinase increases expression ISO tolcapone results in increased expression of MVK mRNA CTD PMID:24136188 NCBI chr12:109,573,272...109,598,125
Ensembl chr12:109,573,255...109,598,125
JBrowse link
G NAA20 N-alpha-acetyltransferase 20, NatB catalytic subunit decreases expression ISO tolcapone results in decreased expression of NAA20 mRNA CTD PMID:24136188 NCBI chr20:20,017,290...20,033,655
Ensembl chr20:20,017,310...20,033,655
JBrowse link
G NAT10 N-acetyltransferase 10 affects binding ISO tolcapone binds to NAT10 protein CTD PMID:19783845 NCBI chr11:34,105,629...34,146,908
Ensembl chr11:34,105,617...34,147,670
JBrowse link
G NDUFA1 NADH:ubiquinone oxidoreductase subunit A1 decreases expression ISO tolcapone results in decreased expression of NDUFA1 mRNA CTD PMID:24136188 NCBI chr  X:119,871,832...119,876,662
Ensembl chr  X:119,871,832...119,876,662
JBrowse link
G NDUFA2 NADH:ubiquinone oxidoreductase subunit A2 decreases expression ISO tolcapone results in decreased expression of NDUFA2 mRNA CTD PMID:24136188 NCBI chr 5:140,645,285...140,647,630
Ensembl chr 5:140,638,740...140,647,771
JBrowse link
G NDUFA6 NADH:ubiquinone oxidoreductase subunit A6 decreases expression ISO tolcapone results in decreased expression of NDUFA6 mRNA CTD PMID:24136188 NCBI chr22:42,085,526...42,090,772
Ensembl chr22:42,085,526...42,090,884
JBrowse link
G NDUFA7 NADH:ubiquinone oxidoreductase subunit A7 decreases expression ISO tolcapone results in decreased expression of NDUFA7 mRNA CTD PMID:24136188 NCBI chr19:8,308,595...8,321,375
Ensembl chr19:8,308,768...8,321,375
JBrowse link
G NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 affects binding ISO tolcapone binds to NDUFA9 protein CTD PMID:19783845 NCBI chr12:4,649,114...4,694,317
Ensembl chr12:4,649,095...4,694,317
JBrowse link
G NDUFB6 NADH:ubiquinone oxidoreductase subunit B6 decreases expression ISO tolcapone results in decreased expression of NDUFB6 mRNA CTD PMID:24136188 NCBI chr 9:32,553,001...32,573,159
Ensembl chr 9:32,553,001...32,573,184
JBrowse link
G NDUFC2 NADH:ubiquinone oxidoreductase subunit C2 decreases expression ISO tolcapone results in decreased expression of NDUFC2 mRNA CTD PMID:24136188 NCBI chr11:78,068,297...78,079,862
Ensembl chr11:78,068,297...78,079,862
JBrowse link
G NDUFS4 NADH:ubiquinone oxidoreductase subunit S4 decreases expression ISO tolcapone results in decreased expression of NDUFS4 mRNA CTD PMID:24136188 NCBI chr 5:53,560,639...53,683,338
Ensembl chr 5:53,560,633...53,683,338
JBrowse link
G NDUFS5 NADH:ubiquinone oxidoreductase subunit S5 decreases expression ISO tolcapone results in decreased expression of NDUFS5 mRNA CTD PMID:24136188 NCBI chr 1:39,026,350...39,034,615
Ensembl chr 1:39,026,318...39,034,636
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 decreases expression EXP tolcapone results in decreased expression of NFE2L2 mRNA CTD PMID:28526448 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NIPSNAP1 nipsnap homolog 1 affects binding ISO tolcapone binds to NIPSNAP1 protein CTD PMID:19783845 NCBI chr22:29,554,808...29,581,113
Ensembl chr22:29,554,808...29,581,327
JBrowse link
G NIPSNAP2 nipsnap homolog 2 affects binding ISO tolcapone binds to NIPSNAP2 protein CTD PMID:19783845 NCBI chr 7:55,964,585...56,000,179
Ensembl chr 7:55,951,793...56,000,181
JBrowse link
G NME3 NME/NM23 nucleoside diphosphate kinase 3 decreases expression ISO tolcapone results in decreased expression of NME3 mRNA CTD PMID:24136188 NCBI chr16:1,770,320...1,771,543
Ensembl chr16:1,770,320...1,771,561
JBrowse link
G NOP56 NOP56 ribonucleoprotein affects binding ISO tolcapone binds to NOP56 protein CTD PMID:19783845 NCBI chr20:2,652,632...2,658,393
Ensembl chr20:2,652,593...2,658,393
JBrowse link
G NPHP1 nephrocystin 1 decreases expression ISO tolcapone results in decreased expression of NPHP1 mRNA CTD PMID:24136188 NCBI chr 2:110,123,348...110,205,013
Ensembl chr 2:110,122,311...110,205,066
JBrowse link
G NPLOC4 NPL4 homolog, ubiquitin recognition factor increases expression ISO tolcapone results in increased expression of NPLOC4 mRNA CTD PMID:24136188 NCBI chr17:81,556,885...81,637,112
Ensembl chr17:81,556,887...81,648,465
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 decreases expression ISO tolcapone results in decreased expression of NR3C1 mRNA CTD PMID:24136188 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G NUPR2 nuclear protein 2, transcriptional regulator decreases expression ISO tolcapone results in decreased expression of NUPR2 mRNA CTD PMID:24136188 NCBI chr 7:56,114,681...56,116,417
Ensembl chr 7:56,114,681...56,116,417
JBrowse link
G P4HA1 prolyl 4-hydroxylase subunit alpha 1 affects binding ISO tolcapone binds to P4HA1 protein CTD PMID:19783845 NCBI chr10:73,007,217...73,096,866
Ensembl chr10:73,007,217...73,096,974
JBrowse link
G PC pyruvate carboxylase affects binding ISO tolcapone binds to PC protein CTD PMID:19783845 NCBI chr11:66,848,420...66,958,383
Ensembl chr11:66,848,417...66,958,386
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression ISO tolcapone results in decreased expression of PCNA mRNA CTD PMID:24136188 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PCYT1A phosphate cytidylyltransferase 1A, choline affects binding ISO tolcapone binds to PCYT1A protein CTD PMID:19783845 NCBI chr 3:196,234,368...196,287,726
Ensembl chr 3:196,214,222...196,287,957
JBrowse link
G PDZD11 PDZ domain containing 11 decreases expression ISO tolcapone results in decreased expression of PDZD11 mRNA CTD PMID:24136188 NCBI chr  X:70,286,595...70,289,927
Ensembl chr  X:70,281,118...70,290,514
JBrowse link
G PFDN1 prefoldin subunit 1 decreases expression ISO tolcapone results in decreased expression of PFDN1 mRNA CTD PMID:24136188 NCBI chr 5:140,245,035...140,303,101
Ensembl chr 5:140,245,035...140,303,113
JBrowse link
G PFDN5 prefoldin subunit 5 decreases expression ISO tolcapone results in decreased expression of PFDN5 mRNA CTD PMID:24136188 NCBI chr12:53,295,542...53,299,450
Ensembl chr12:53,295,291...53,299,452
JBrowse link
G PGM1 phosphoglucomutase 1 increases expression ISO tolcapone results in increased expression of PGM1 mRNA CTD PMID:24136188 NCBI chr 1:63,593,411...63,660,245
Ensembl chr 1:63,593,411...63,660,245
JBrowse link
G PGR progesterone receptor multiple interactions EXP tolcapone binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PIGP phosphatidylinositol glycan anchor biosynthesis class P decreases expression ISO tolcapone results in decreased expression of PIGP mRNA CTD PMID:24136188 NCBI chr21:37,065,364...37,073,071
Ensembl chr21:37,062,846...37,073,170
JBrowse link
G PIGS phosphatidylinositol glycan anchor biosynthesis class S affects binding ISO tolcapone binds to PIGS protein CTD PMID:19783845 NCBI chr17:28,553,387...28,571,524
Ensembl chr17:28,553,383...28,571,794
JBrowse link
G PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 decreases expression ISO tolcapone results in decreased expression of PIN4 mRNA CTD PMID:24136188 NCBI chr  X:72,181,676...72,263,964
Ensembl chr  X:72,181,353...72,302,926
JBrowse link
G PLIN2 perilipin 2 affects binding ISO tolcapone binds to PLIN2 protein CTD PMID:19783845 NCBI chr 9:19,108,388...19,127,492
Ensembl chr 9:19,108,375...19,149,290
JBrowse link
G PLIN3 perilipin 3 affects binding ISO tolcapone binds to PLIN3 protein CTD PMID:19783845 NCBI chr19:4,838,341...4,867,667
Ensembl chr19:4,838,341...4,867,694
JBrowse link
G PNPLA2 patatin like phospholipase domain containing 2 increases expression ISO tolcapone results in increased expression of PNPLA2 mRNA CTD PMID:24136188 NCBI chr11:818,914...825,573
Ensembl chr11:818,914...825,573
JBrowse link
G POLR1H RNA polymerase I subunit H decreases expression ISO Tolcapone results in decreased expression of POLR1H mRNA CTD PMID:24136188 NCBI chr 6:30,060,062...30,064,907
Ensembl chr 6:30,058,899...30,064,909
JBrowse link
G POLR2G RNA polymerase II subunit G decreases expression ISO tolcapone results in decreased expression of POLR2G mRNA CTD PMID:24136188 NCBI chr11:62,761,580...62,766,710
Ensembl chr11:62,761,565...62,766,710
JBrowse link
G PRPF8 pre-mRNA processing factor 8 affects binding ISO tolcapone binds to PRPF8 protein CTD PMID:19783845 NCBI chr17:1,650,629...1,684,867
Ensembl chr17:1,650,629...1,684,867
JBrowse link
G PRXL2A peroxiredoxin like 2A affects binding ISO tolcapone binds to PRXL2A protein CTD PMID:19783845 NCBI chr10:80,407,829...80,437,115
Ensembl chr10:80,407,829...80,437,115
JBrowse link
G PSMC5 proteasome 26S subunit, ATPase 5 affects binding ISO tolcapone binds to PSMC5 protein CTD PMID:19783845 NCBI chr17:63,827,431...63,832,019
Ensembl chr17:63,827,152...63,832,026
JBrowse link
G PSME2 proteasome activator subunit 2 affects binding ISO tolcapone binds to PSME2 protein CTD PMID:19783845 NCBI chr14:24,143,365...24,146,610
Ensembl chr14:24,143,362...24,147,570
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP Tolcapone results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PTRH2 peptidyl-tRNA hydrolase 2 affects binding ISO tolcapone binds to PTRH2 protein CTD PMID:19783845 NCBI chr17:59,697,308...59,707,430
Ensembl chr17:59,674,636...59,707,626
JBrowse link
G RAMAC RNA guanine-7 methyltransferase activating subunit decreases expression ISO tolcapone results in decreased expression of RAMAC mRNA CTD PMID:24136188 NCBI chr15:82,986,210...82,991,057
Ensembl chr15:82,986,210...82,991,057
JBrowse link
G RAN RAN, member RAS oncogene family affects binding ISO tolcapone binds to RAN protein CTD PMID:19783845 NCBI chr12:130,872,066...130,877,678
Ensembl chr12:130,872,037...130,877,678
JBrowse link
G RAP1A RAP1A, member of RAS oncogene family decreases expression ISO tolcapone results in decreased expression of RAP1A mRNA CTD PMID:24136188 NCBI chr 1:111,542,009...111,716,691
Ensembl chr 1:111,542,218...111,716,691
JBrowse link
G RBIS ribosomal biogenesis factor decreases expression ISO Tolcapone results in decreased expression of RBIS mRNA CTD PMID:24136188 NCBI chr 8:85,214,048...85,220,374
Ensembl chr 8:85,214,048...85,220,421
JBrowse link
G RBM8A RNA binding motif protein 8A decreases expression ISO tolcapone results in decreased expression of RBM8A mRNA CTD PMID:24136188 NCBI chr 1:145,921,556...145,927,484
Ensembl chr 1:145,921,556...145,927,678
JBrowse link
G RBP1 retinol binding protein 1 decreases expression ISO tolcapone results in decreased expression of RBP1 mRNA CTD PMID:24136188 NCBI chr 3:139,517,438...139,539,742
Ensembl chr 3:139,517,434...139,539,829
JBrowse link
G REEP6 receptor accessory protein 6 affects binding ISO tolcapone binds to REEP6 protein CTD PMID:19783845 NCBI chr19:1,491,181...1,497,927
Ensembl chr19:1,491,166...1,497,927
JBrowse link
G RNF7 ring finger protein 7 decreases expression ISO tolcapone results in decreased expression of RNF7 mRNA CTD PMID:24136188 NCBI chr 3:141,738,298...141,747,560
Ensembl chr 3:141,738,249...141,747,560
JBrowse link
G RNLS renalase, FAD dependent amine oxidase decreases expression ISO tolcapone results in decreased expression of RNLS mRNA CTD PMID:24136188 NCBI chr10:88,171,523...88,583,318
Ensembl chr10:88,273,864...88,584,530
JBrowse link
G ROMO1 reactive oxygen species modulator 1 decreases expression ISO tolcapone results in decreased expression of ROMO1 mRNA CTD PMID:24136188 NCBI chr20:35,699,405...35,700,980
Ensembl chr20:35,699,272...35,700,984
JBrowse link
G RPA3 replication protein A3 decreases expression ISO tolcapone results in decreased expression of RPA3 mRNA CTD PMID:24136188 NCBI chr 7:7,636,518...7,718,607
Ensembl chr 7:7,636,518...7,718,607
JBrowse link
G RPL10A ribosomal protein L10a affects binding ISO tolcapone binds to RPL10A protein CTD PMID:19783845 NCBI chr 6:35,468,401...35,470,780
Ensembl chr 6:35,468,401...35,470,785
JBrowse link
G RPL15 ribosomal protein L15 affects binding ISO tolcapone binds to RPL15 protein CTD PMID:19783845 NCBI chr 3:23,916,545...23,924,631
Ensembl chr 3:23,916,591...23,924,374
JBrowse link
G RPL18A ribosomal protein L18a affects binding ISO tolcapone binds to RPL18A protein CTD PMID:19783845 NCBI chr19:17,859,910...17,863,319
Ensembl chr19:17,859,910...17,864,153
JBrowse link
G RPL22 ribosomal protein L22 affects binding ISO tolcapone binds to RPL22 protein CTD PMID:19783845 NCBI chr 1:6,185,020...6,199,595
Ensembl chr 1:6,185,020...6,209,389
JBrowse link
G RPL22L1 ribosomal protein L22 like 1 decreases expression ISO tolcapone results in decreased expression of RPL22L1 mRNA CTD PMID:24136188 NCBI chr 3:170,864,875...170,870,195
Ensembl chr 3:170,864,875...170,870,208
JBrowse link
G RPL23 ribosomal protein L23 affects binding ISO tolcapone binds to RPL23 protein CTD PMID:19783845 NCBI chr17:38,847,860...38,853,721
Ensembl chr17:38,847,860...38,868,644
JBrowse link
G RPL35A ribosomal protein L35a decreases expression ISO tolcapone results in decreased expression of RPL35A mRNA CTD PMID:24136188 NCBI chr 3:197,950,190...197,956,610
Ensembl chr 3:197,950,190...197,956,610
JBrowse link
G RPL36A ribosomal protein L36a decreases expression ISO tolcapone results in decreased expression of RPL36A mRNA CTD PMID:24136188 NCBI chr  X:101,391,011...101,396,155
Ensembl chr  X:101,390,824...101,396,155
JBrowse link
G RPL41 ribosomal protein L41 decreases expression ISO tolcapone results in decreased expression of RPL41 mRNA CTD PMID:24136188 NCBI chr12:56,116,633...56,117,967
Ensembl chr12:56,116,590...56,117,967
JBrowse link
G RPL7A ribosomal protein L7a affects binding ISO tolcapone binds to RPL7A protein CTD PMID:19783845 NCBI chr 9:133,348,218...133,351,426
Ensembl chr 9:133,348,218...133,351,426
JBrowse link
G RPL7L1 ribosomal protein L7 like 1 affects binding ISO tolcapone binds to RPL7L1 protein CTD PMID:19783845 NCBI chr 6:42,879,616...42,889,900
Ensembl chr 6:42,879,616...42,889,925
JBrowse link
G RPL9 ribosomal protein L9 decreases expression ISO tolcapone results in decreased expression of RPL9 mRNA CTD PMID:24136188 NCBI chr 4:39,454,124...39,458,922
Ensembl chr 4:39,452,587...39,458,931
JBrowse link
G RPP21 ribonuclease P/MRP subunit p21 decreases expression ISO tolcapone results in decreased expression of RPP21 mRNA CTD PMID:24136188 NCBI chr 6:30,345,156...30,346,857
Ensembl chr 6:30,345,131...30,346,884
JBrowse link
G RPS11 ribosomal protein S11 affects binding ISO tolcapone binds to RPS11 protein CTD PMID:19783845 NCBI chr19:49,496,434...49,499,708
Ensembl chr19:49,496,365...49,499,708
JBrowse link
G RPS14 ribosomal protein S14 affects binding ISO tolcapone binds to RPS14 protein CTD PMID:19783845 NCBI chr 5:150,442,635...150,449,739
Ensembl chr 5:150,442,635...150,449,739
JBrowse link
G RPS15A ribosomal protein S15a decreases expression ISO tolcapone results in decreased expression of RPS15A mRNA CTD PMID:24136188 NCBI chr16:18,781,295...18,790,334
Ensembl chr16:18,781,295...18,790,383
JBrowse link
G RPS20 ribosomal protein S20 affects binding ISO tolcapone binds to RPS20 protein CTD PMID:19783845 NCBI chr 8:56,067,254...56,074,506
Ensembl chr 8:56,067,254...56,074,510
JBrowse link
G RPS21 ribosomal protein S21 decreases expression ISO tolcapone results in decreased expression of RPS21 mRNA CTD PMID:24136188 NCBI chr20:62,387,103...62,388,520
Ensembl chr20:62,387,103...62,388,520
JBrowse link
G RPS24 ribosomal protein S24 decreases expression ISO tolcapone results in decreased expression of RPS24 mRNA CTD PMID:24136188 NCBI chr10:78,033,863...78,056,806
Ensembl chr10:78,033,760...78,056,813
JBrowse link
G RPS25 ribosomal protein S25 decreases expression ISO tolcapone results in decreased expression of RPS25 mRNA CTD PMID:24136188 NCBI chr11:119,015,717...119,018,343
Ensembl chr11:119,015,712...119,018,691
JBrowse link
G RPS27 ribosomal protein S27 decreases expression ISO tolcapone results in decreased expression of RPS27 mRNA CTD PMID:24136188 NCBI chr 1:153,990,762...153,992,155
Ensembl chr 1:153,990,762...153,992,155
JBrowse link
G RPS27A ribosomal protein S27a affects binding ISO tolcapone binds to RPS27A protein CTD PMID:19783845 NCBI chr 2:55,231,903...55,235,853
Ensembl chr 2:55,231,903...55,235,853
JBrowse link
G S100A10 S100 calcium binding protein A10 decreases expression ISO tolcapone results in decreased expression of S100A10 mRNA CTD PMID:24136188 NCBI chr 1:151,982,915...151,993,859
Ensembl chr 1:151,982,915...151,993,859
JBrowse link
G SC5D sterol-C5-desaturase increases expression ISO tolcapone results in increased expression of SC5D mRNA CTD PMID:24136188 NCBI chr11:121,292,771...121,313,410
Ensembl chr11:121,292,681...121,313,410
JBrowse link
G SCD stearoyl-CoA desaturase affects binding
decreases expression
ISO tolcapone binds to SCD protein
tolcapone results in decreased expression of SCD1 mRNA
CTD PMID:19783845 PMID:24136188 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SDHA succinate dehydrogenase complex flavoprotein subunit A affects binding ISO tolcapone binds to SDHA protein CTD PMID:19783845 NCBI chr 5:218,320...268,746
Ensembl chr 5:218,303...257,082
JBrowse link
G SDHB succinate dehydrogenase complex iron sulfur subunit B affects binding ISO tolcapone binds to SDHB protein CTD PMID:19783845 NCBI chr 1:17,018,722...17,054,032
Ensembl chr 1:17,018,664...17,054,151
JBrowse link
G SEC11C SEC11 homolog C, signal peptidase complex subunit affects binding ISO tolcapone binds to SEC11C protein CTD PMID:19783845 NCBI chr18:59,139,884...59,158,832
Ensembl chr18:59,139,475...59,158,832
JBrowse link
G SEC31A SEC31 homolog A, COPII coat complex component affects binding ISO tolcapone binds to SEC31A protein CTD PMID:19783845 NCBI chr 4:82,818,509...82,900,569
Ensembl chr 4:82,818,509...82,901,166
JBrowse link
G SERBP1 SERPINE1 mRNA binding protein 1 affects binding ISO tolcapone binds to SERBP1 protein CTD PMID:19783845 NCBI chr 1:67,407,810...67,430,402
Ensembl chr 1:67,407,810...67,430,415
JBrowse link
G SF3B6 splicing factor 3b subunit 6 affects binding ISO tolcapone binds to SF3B6 protein CTD PMID:19783845 NCBI chr 2:24,067,586...24,076,326
Ensembl chr 2:24,067,586...24,076,373
JBrowse link
G SFXN1 sideroflexin 1 affects binding ISO tolcapone binds to SFXN1 protein CTD PMID:19783845 NCBI chr 5:175,478,560...175,529,742
Ensembl chr 5:175,477,062...175,529,742
JBrowse link
G SIK3 SIK family kinase 3 increases expression ISO tolcapone results in increased expression of SIK3 mRNA CTD PMID:24136188 NCBI chr11:116,843,402...117,098,428
Ensembl chr11:116,843,402...117,098,437
JBrowse link
G SLC1A5 solute carrier family 1 member 5 affects binding ISO tolcapone binds to SLC1A5 protein CTD PMID:19783845 NCBI chr19:46,774,883...46,788,594
Ensembl chr19:46,774,883...46,788,594
JBrowse link
G SLC25A1 solute carrier family 25 member 1 affects binding ISO tolcapone binds to SLC25A1 protein CTD PMID:19783845 NCBI chr22:19,175,581...19,178,736
Ensembl chr22:19,175,581...19,178,739
JBrowse link
G SLC25A13 solute carrier family 25 member 13 affects binding ISO tolcapone binds to SLC25A13 protein CTD PMID:19783845 NCBI chr 7:96,120,220...96,322,098
Ensembl chr 7:96,120,220...96,322,147
JBrowse link
G SLC25A4 solute carrier family 25 member 4 affects binding ISO tolcapone binds to SLC25A4 protein CTD PMID:19783845 NCBI chr 4:185,143,266...185,150,382
Ensembl chr 4:185,143,266...185,150,382
JBrowse link
G SLC25A5 solute carrier family 25 member 5 affects binding ISO tolcapone binds to SLC25A5 protein CTD PMID:19783845 NCBI chr  X:119,468,444...119,471,396
Ensembl chr  X:119,468,422...119,471,396
JBrowse link
G SLC25A6 solute carrier family 25 member 6 affects binding ISO tolcapone binds to SLC25A6 protein CTD PMID:19783845 NCBI chr  X:1,386,152...1,392,113
NCBI chr  Y:1,386,152...1,392,113
Ensembl chr  X:1,386,152...1,392,113
Ensembl chr  Y:1,386,152...1,392,113
JBrowse link
G SLC39A7 solute carrier family 39 member 7 affects binding ISO tolcapone binds to SLC39A7 protein CTD PMID:19783845 NCBI chr 6:33,200,867...33,204,437
Ensembl chr 6:33,200,305...33,204,439
JBrowse link
G SLC7A11 solute carrier family 7 member 11 decreases expression EXP Tolcapone results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SLPI secretory leukocyte peptidase inhibitor decreases expression EXP Tolcapone results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564
JBrowse link
G SMIM26 small integral membrane protein 26 decreases expression ISO tolcapone results in decreased expression of SMIM26 mRNA CTD PMID:24136188 NCBI chr20:18,567,432...18,569,611
Ensembl chr20:18,567,347...18,569,563
JBrowse link
G SNAPIN SNAP associated protein decreases expression ISO tolcapone results in decreased expression of SNAPIN mRNA CTD PMID:24136188 NCBI chr 1:153,658,654...153,661,852
Ensembl chr 1:153,658,703...153,661,852
JBrowse link
G SNCA synuclein alpha multiple interactions EXP tolcapone inhibits the reaction [SNCA protein binds to SNCA protein] CTD PMID:20150427 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SNRNP27 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 decreases expression ISO Tolcapone results in decreased expression of SNRNP27 mRNA CTD PMID:24136188 NCBI chr 2:69,893,956...69,905,236
Ensembl chr 2:69,893,956...69,905,575
JBrowse link
G SNRPB2 small nuclear ribonucleoprotein polypeptide B2 decreases expression ISO tolcapone results in decreased expression of SNRPB2 mRNA CTD PMID:24136188 NCBI chr20:16,730,026...16,742,564
Ensembl chr20:16,729,961...16,742,564
JBrowse link
G SNRPD3 small nuclear ribonucleoprotein D3 polypeptide decreases expression ISO tolcapone results in decreased expression of SNRPD3 mRNA CTD PMID:24136188 NCBI chr22:24,555,650...24,574,971
Ensembl chr22:24,555,958...24,582,052
JBrowse link
G SNRPE small nuclear ribonucleoprotein polypeptide E decreases expression ISO tolcapone results in decreased expression of SNRPE mRNA CTD PMID:24136188 NCBI chr 1:203,861,599...203,871,152
Ensembl chr 1:203,861,599...203,871,152
JBrowse link
G SNRPF small nuclear ribonucleoprotein polypeptide F decreases expression ISO tolcapone results in decreased expression of SNRPF mRNA CTD PMID:24136188 NCBI chr12:95,858,952...95,866,140
Ensembl chr12:95,858,952...95,903,828
JBrowse link
G SNRPG small nuclear ribonucleoprotein polypeptide G decreases expression ISO tolcapone results in decreased expression of SNRPG mRNA CTD PMID:24136188 NCBI chr 2:70,281,362...70,293,740
Ensembl chr 2:70,281,362...70,293,740
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression EXP tolcapone results in decreased expression of SOD1 mRNA CTD PMID:28526448 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 decreases expression EXP tolcapone results in decreased expression of SOD2 mRNA CTD PMID:28526448 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SRP14 signal recognition particle 14 decreases expression ISO tolcapone results in decreased expression of SRP14 mRNA CTD PMID:24136188 NCBI chr15:40,035,690...40,039,202
Ensembl chr15:40,035,690...40,039,181
JBrowse link
G SRPRB SRP receptor subunit beta affects binding ISO tolcapone binds to SRPRB protein CTD PMID:19783845 NCBI chr 3:133,784,023...133,828,574
Ensembl chr 3:133,784,023...133,825,772
JBrowse link
G SS18L2 SS18 like 2 decreases expression ISO tolcapone results in decreased expression of SS18L2 mRNA CTD PMID:24136188 NCBI chr 3:42,581,840...42,596,934
Ensembl chr 3:42,581,840...42,596,934
JBrowse link
G SSR1 signal sequence receptor subunit 1 affects binding ISO tolcapone binds to SSR1 protein CTD PMID:19783845 NCBI chr 6:7,281,143...7,313,199
Ensembl chr 6:7,268,306...7,347,446
JBrowse link
G STAC3 SH3 and cysteine rich domain 3 decreases expression ISO tolcapone results in decreased expression of STAC3 mRNA CTD PMID:24136188 NCBI chr12:57,243,458...57,251,187
Ensembl chr12:57,243,453...57,251,188
JBrowse link
G STAT3 signal transducer and activator of transcription 3 increases expression ISO tolcapone results in increased expression of STAT3 mRNA CTD PMID:24136188 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 affects binding ISO tolcapone binds to SULT2A1 protein CTD PMID:19783845 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315
JBrowse link
G TAF9 TATA-box binding protein associated factor 9 decreases expression ISO tolcapone results in decreased expression of TAF9 mRNA CTD PMID:24136188 NCBI chr 5:69,364,743...69,369,824
Ensembl chr 5:69,362,026...69,370,013
JBrowse link
G TBCA tubulin folding cofactor A decreases expression ISO tolcapone results in decreased expression of TBCA mRNA CTD PMID:24136188 NCBI chr 5:77,691,166...77,776,339
Ensembl chr 5:77,691,166...77,868,780
JBrowse link
G TCEAL8 transcription elongation factor A like 8 decreases expression ISO tolcapone results in decreased expression of TCEAL8 mRNA CTD PMID:24136188 NCBI chr  X:103,252,995...103,255,155
Ensembl chr  X:103,252,995...103,255,192
JBrowse link
G TFR2 transferrin receptor 2 increases expression ISO tolcapone results in increased expression of TFR2 mRNA CTD PMID:24136188 NCBI chr 7:100,620,420...100,641,552
Ensembl chr 7:100,620,416...100,642,779
JBrowse link
G TIMM10 translocase of inner mitochondrial membrane 10 decreases expression ISO tolcapone results in decreased expression of TIMM10 mRNA CTD PMID:24136188 NCBI chr11:57,528,464...57,530,754
Ensembl chr11:57,528,464...57,530,803
JBrowse link
G TIMM44 translocase of inner mitochondrial membrane 44 affects binding ISO tolcapone binds to TIMM44 protein CTD PMID:19783845 NCBI chr19:7,926,718...7,943,666
Ensembl chr19:7,926,718...7,943,667
JBrowse link
G TIMM8B translocase of inner mitochondrial membrane 8 homolog B decreases expression ISO tolcapone results in decreased expression of TIMM8B mRNA CTD PMID:24136188 NCBI chr11:112,084,800...112,086,756
Ensembl chr11:112,084,800...112,086,798
JBrowse link
G TK2 thymidine kinase 2 affects binding ISO tolcapone binds to TK2 protein CTD PMID:19783845 NCBI chr16:66,508,003...66,550,291
Ensembl chr16:66,508,003...66,552,544
JBrowse link
G TM2D1 TM2 domain containing 1 decreases expression ISO tolcapone results in decreased expression of TM2D1 mRNA CTD PMID:24136188 NCBI chr 1:61,681,046...61,725,141
Ensembl chr 1:61,681,046...61,725,423
JBrowse link
G TMED10 transmembrane p24 trafficking protein 10 affects binding ISO tolcapone binds to TMED10 protein CTD PMID:19783845 NCBI chr14:75,131,469...75,176,612
Ensembl chr14:75,131,469...75,176,612
JBrowse link
G TMED4 transmembrane p24 trafficking protein 4 affects binding ISO tolcapone binds to TMED4 protein CTD PMID:19783845 NCBI chr 7:44,577,894...44,582,231
Ensembl chr 7:44,576,392...44,582,287
JBrowse link
G TMED9 transmembrane p24 trafficking protein 9 affects binding ISO tolcapone binds to TMED9 protein CTD PMID:19783845 NCBI chr 5:177,592,203...177,597,242
Ensembl chr 5:177,592,203...177,597,242
JBrowse link
G TMEM126A transmembrane protein 126A decreases expression ISO tolcapone results in decreased expression of TMEM126A mRNA CTD PMID:24136188 NCBI chr11:85,647,967...85,656,542
Ensembl chr11:85,647,967...85,656,547
JBrowse link
G TMEM126B transmembrane protein 126B decreases expression ISO tolcapone results in decreased expression of TMEM126B mRNA CTD PMID:24136188 NCBI chr11:85,628,573...85,636,540
Ensembl chr11:85,628,573...85,636,539
JBrowse link
G TMEM128 transmembrane protein 128 decreases expression ISO tolcapone results in decreased expression of TMEM128 mRNA CTD PMID:24136188 NCBI chr 4:4,235,542...4,248,223
Ensembl chr 4:4,235,542...4,248,223
JBrowse link
G TMEM203 transmembrane protein 203 decreases expression ISO tolcapone results in decreased expression of TMEM203 mRNA CTD PMID:24136188 NCBI chr 9:137,204,082...137,205,648
Ensembl chr 9:137,204,082...137,205,648
JBrowse link
G TMEM238 transmembrane protein 238 decreases expression ISO tolcapone results in decreased expression of TMEM238 mRNA CTD PMID:24136188 NCBI chr19:55,379,244...55,384,292
Ensembl chr19:55,379,244...55,384,292
JBrowse link
G TMEM256 transmembrane protein 256 decreases expression ISO tolcapone results in decreased expression of TMEM256 mRNA CTD PMID:24136188 NCBI chr17:7,402,975...7,404,097
Ensembl chr17:7,402,975...7,404,097
JBrowse link
G TMSB4X thymosin beta 4 X-linked decreases expression ISO tolcapone results in decreased expression of TMSB4X mRNA CTD PMID:24136188 NCBI chr  X:12,975,110...12,977,223
Ensembl chr  X:12,975,110...12,977,227
JBrowse link
G TNFAIP8 TNF alpha induced protein 8 affects binding ISO tolcapone binds to TNFAIP8 protein CTD PMID:19783845 NCBI chr 5:119,268,759...119,399,688
Ensembl chr 5:119,268,692...119,399,688
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A increases expression ISO tolcapone results in increased expression of TNFRSF1A mRNA CTD PMID:24136188 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G TOMM20 translocase of outer mitochondrial membrane 20 affects binding ISO tolcapone binds to TOMM20 protein CTD PMID:19783845 NCBI chr 1:235,109,341...235,128,837
Ensembl chr 1:235,109,341...235,128,837
JBrowse link
G TOMM40 translocase of outer mitochondrial membrane 40 affects binding ISO tolcapone binds to TOMM40 protein CTD PMID:19783845 NCBI chr19:44,891,254...44,903,689
Ensembl chr19:44,890,569...44,903,689
JBrowse link
G TOMM7 translocase of outer mitochondrial membrane 7 affects binding ISO tolcapone binds to TOMM7 protein CTD PMID:19783845 NCBI chr 7:22,812,974...22,822,849
Ensembl chr 7:22,812,628...22,822,849
JBrowse link
G TP53I3 tumor protein p53 inducible protein 3 decreases expression ISO Tolcapone results in decreased expression of TP53I3 mRNA CTD PMID:24136188 NCBI chr 2:24,077,433...24,084,834
Ensembl chr 2:24,077,433...24,085,861
JBrowse link
G TRAPPC2L trafficking protein particle complex subunit 2L decreases expression ISO tolcapone results in decreased expression of TRAPPC2L mRNA CTD PMID:24136188 NCBI chr16:88,856,220...88,862,678
Ensembl chr16:88,856,220...88,862,686
JBrowse link
G TSPAN6 tetraspanin 6 decreases expression ISO tolcapone results in decreased expression of TSPAN6 mRNA CTD PMID:24136188 NCBI chr  X:100,627,108...100,637,104
Ensembl chr  X:100,627,108...100,639,991
JBrowse link
G TUBB6 tubulin beta 6 class V affects binding ISO tolcapone binds to TUBB6 protein CTD PMID:19783845 NCBI chr18:12,307,669...12,329,826
Ensembl chr18:12,307,669...12,344,320
JBrowse link
G TXNDC17 thioredoxin domain containing 17 decreases expression ISO tolcapone results in decreased expression of TXNDC17 mRNA CTD PMID:24136188 NCBI chr17:6,641,060...6,644,541
Ensembl chr17:6,640,985...6,644,541
JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 decreases glucuronidation
increases glucuronidation
EXP UGT1A9 protein mutant form results in decreased glucuronidation of tolcapone
UGT1A9 protein results in increased glucuronidation of tolcapone
CTD PMID:16344532 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300
JBrowse link
G UQCRC2 ubiquinol-cytochrome c reductase core protein 2 affects binding ISO tolcapone binds to UQCRC2 protein CTD PMID:19783845 NCBI chr16:21,953,361...21,983,660
Ensembl chr16:21,953,288...21,983,660
JBrowse link
G UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 affects binding ISO tolcapone binds to UQCRFS1 protein CTD PMID:19783845 NCBI chr19:29,205,320...29,213,151
Ensembl chr19:29,205,320...29,213,151
JBrowse link
G UVRAG UV radiation resistance associated increases expression ISO tolcapone results in increased expression of UVRAG mRNA CTD PMID:24136188 NCBI chr11:75,815,210...76,144,232
Ensembl chr11:75,815,210...76,144,232
JBrowse link
G VDAC2 voltage dependent anion channel 2 affects binding ISO tolcapone binds to VDAC2 protein CTD PMID:19783845 NCBI chr10:75,210,170...75,231,448
Ensembl chr10:75,210,154...75,231,448
JBrowse link
G VDAC3 voltage dependent anion channel 3 affects binding ISO tolcapone binds to VDAC3 protein CTD PMID:19783845 NCBI chr 8:42,391,880...42,405,937
Ensembl chr 8:42,391,624...42,405,937
JBrowse link
G VSNL1 visinin like 1 affects binding ISO tolcapone binds to VSNL1 protein CTD PMID:19783845 NCBI chr 2:17,539,972...17,657,018
Ensembl chr 2:17,539,126...17,657,018
JBrowse link
G WASHC3 WASH complex subunit 3 decreases expression ISO tolcapone results in decreased expression of WASHC3 mRNA CTD PMID:24136188 NCBI chr12:102,012,840...102,062,124
Ensembl chr12:102,012,840...102,062,149
JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein affects binding ISO tolcapone binds to WFS1 protein CTD PMID:19783845 NCBI chr 4:6,269,850...6,303,265
Ensembl chr 4:6,269,849...6,303,265
JBrowse link
G YARS1 tyrosyl-tRNA synthetase 1 increases expression ISO Tolcapone results in increased expression of YARS1 mRNA CTD PMID:24136188 NCBI chr 1:32,775,239...32,817,358
Ensembl chr 1:32,775,237...32,818,031
JBrowse link
G YEATS4 YEATS domain containing 4 decreases expression ISO tolcapone results in decreased expression of YEATS4 mRNA CTD PMID:24136188 NCBI chr12:69,359,743...69,427,072
Ensembl chr12:69,359,710...69,390,870
JBrowse link
G ZNRF1 zinc and ring finger 1 increases expression ISO tolcapone results in increased expression of ZNRF1 mRNA CTD PMID:24136188 NCBI chr16:74,999,024...75,110,994
Ensembl chr16:74,999,024...75,110,994
JBrowse link
trifluridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP CA 074 methyl ester inhibits the reaction [Trifluridine results in increased cleavage of CASP3 protein]; Trifluridine results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:19816940 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP8 caspase 8 increases cleavage EXP Trifluridine results in increased cleavage of CASP8 protein CTD PMID:19816940 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G CASP9 caspase 9 increases cleavage EXP Trifluridine results in increased cleavage of CASP9 protein CTD PMID:19816940 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CTSB cathepsin B increases cleavage
multiple interactions
EXP Trifluridine results in increased cleavage of CTSB protein
CA 074 methyl ester inhibits the reaction [Trifluridine results in increased cleavage of CTSB protein]
CTD PMID:19816940 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP [Trifluridine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions EXP Trifluridine inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G ESRRA estrogen related receptor alpha multiple interactions EXP Trifluridine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr11:64,305,524...64,316,743
Ensembl chr11:64,305,497...64,316,743
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases activity EXP Trifluridine results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity
multiple interactions
EXP Trifluridine results in increased activity of NR1I2 protein
[Trifluridine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions EXP Trifluridine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] CTD PMID:30818834 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP Trifluridine results in increased cleavage of PARP1 protein CTD PMID:19816940 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G TP53 tumor protein p53 affects activity EXP Trifluridine affects the activity of TP53 protein CTD PMID:35435491 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26568
    role 26394
      biological role 26373
        biochemical role 25602
          enzyme inhibitor 22434
            EC 2.* (transferase) inhibitor 16122
              EC 2.1.* (C1-transferase) inhibitor 3738
                EC 2.1.1.* (methyltransferases) inhibitor 717
                  BIX-01294 trihydrochloride 0
                  EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor + 277
                  EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor + 307
                  EC 2.1.1.348 (mRNA m6A methyltransferase) inhibitor + 0
                  EC 2.1.1.354 ([histone H3]-lysine(4) N-trimethyltransferase) inhibitor + 8
                  EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitor + 0
                  EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitor + 0
                  EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor + 2
                  EC 2.1.1.45 (thymidylate synthase) inhibitor + 52
                  EC 2.1.1.6 (catechol O-methyltransferase) inhibitor + 356
                  EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor + 28
                  EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor + 28
                  EC 2.1.1.8 (histamine N-methyltransferase) inhibitor + 47
                  sterol methyltransferase inhibitor + 0
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