EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	*EC 1.4.3. (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor**	go back to main search page
Accession:	CHEBI:76861	browse the term
Definition:	An EC 1.4.* (oxidoreductase acting on donor CH-NH₂ group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.4.3.*).
Synonyms:	related_synonym:	EC 1.4.3.* inhibitor; EC 1.4.3.* inhibitors; oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor (EC 1.4.3.*) inhibitors

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Genes (1444)

1-aminobenzotriazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA acetyltransferase 1

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of ACAT1 protein]

NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042

G

acetylcholinesterase

multiple interactions

ISO

1-aminobenzotriazole inhibits the reaction [Chlorpyrifos metabolite results in decreased activity of ACHE protein]

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

acyl-CoA thioesterase 2

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ACOT2 protein]

NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502

G

aldehyde dehydrogenase 1 family, member B1

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ALDH1B1 protein]

NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:64,858,934...64,864,365

G

carbonic anhydrase 3

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of CAR3 protein]

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

CD86 molecule

multiple interactions

ISO

1-aminobenzotriazole inhibits the reaction [Benzo(a)pyrene results in increased expression of CD86 protein]

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361

G

carboxylesterase 3a

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of CES3B protein]

NCBI chr19:49,902,312...49,910,484

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

ISO
EXP

1-aminobenzotriazole inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA]
1-aminobenzotriazole results in increased expression of CYP1A1 protein
1-aminobenzotriazole inhibits the reaction [Oxygen results in increased activity of CYP1A1 protein]; [1-aminobenzotriazole co-treated with Oxygen] results in increased activity of CYP1A1 protein

PMID:10640292 PMID:20187624

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression
decreases activity
multiple interactions

EXP
ISO

1-aminobenzotriazole results in increased expression of CYP1A2 protein
1-aminobenzotriazole results in decreased activity of CYP1A2 protein
[1-aminobenzotriazole co-treated with Oxygen] results in increased activity of CYP1A2 protein; [Oxygen co-treated with 1-aminobenzotriazole] results in increased expression of CYP1A2 protein

PMID:10640292 PMID:15618748

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases activity

ISO

1-aminobenzotriazole inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol]
1-aminobenzotriazole results in decreased activity of CYP2D6 protein

PMID:11375247 PMID:15618748

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity
multiple interactions

ISO

1-aminobenzotriazole results in decreased activity of CYP2E1 protein
1-aminobenzotriazole inhibits the reaction [CYP2E1 protein affects the metabolism of Urethane]; 1-aminobenzotriazole inhibits the reaction [CYP2E1 protein results in increased oxidation of 1,3-butadiene]
1-aminobenzotriazole inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene]

PMID:10828257 PMID:12704224 PMID:15618748 PMID:25243916 PMID:27421776

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 2, subfamily f, polypeptide 4

multiple interactions

ISO

1-aminobenzotriazole inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA]

NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:91,543,768...91,557,553

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

1-aminobenzotriazole results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions

ISO

1-aminobenzotriazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

enoyl-CoA hydratase 1

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of ECH1 protein]

NCBI chr 1:93,241,076...93,248,314
Ensembl chr 1:93,241,734...93,248,440

G

formimidoyltransferase cyclodeaminase

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of FTCD protein]

NCBI chr20:12,054,710...12,068,219
Ensembl chr20:12,054,711...12,068,237

G

ferritin heavy chain 1

multiple interactions

ISO

1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased expression of FTH1 protein]

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

ferritin light chain 1

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of FTL1 protein]

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

glutamic--pyruvic transaminase

multiple interactions

ISO

1-aminobenzotriazole inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; 1-aminobenzotriazole inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; 1-aminobenzotriazole promotes the reaction [Amiodarone promotes the reaction [Dexamethasone results in increased expression of GPT protein]]; [1-aminobenzotriazole co-treated with ochratoxin A] results in increased activity of GPT protein; [Emodin co-treated with 1-aminobenzotriazole] results in increased expression of GPT protein

PMID:25900201 PMID:34492313 PMID:36227364 PMID:38825056

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione S-transferase mu 1

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of GSTM1 protein]

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

H2A.X variant histone

multiple interactions

ISO

1-aminobenzotriazole inhibits the reaction [captax results in increased expression of H2AX protein]; 1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; 1-aminobenzotriazole inhibits the reaction [Trichloroethylene results in increased phosphorylation of H2AX protein]

PMID:28300663 PMID:29722447 PMID:35279910

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

hepatitis A virus cellular receptor 1

multiple interactions

ISO

[1-aminobenzotriazole co-treated with ochratoxin A] results in increased expression of HAVCR1 protein

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

heme oxygenase 1

multiple interactions

ISO

1-aminobenzotriazole inhibits the reaction [[Acetaminophen co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Butylated Hydroxyanisole co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Ticlopidine co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hypoxanthine phosphoribosyltransferase 1

multiple interactions

ISO

1-aminobenzotriazole inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene]

NCBI chr X:137,655,744...137,687,718
Ensembl chr X:137,655,680...137,687,712

G

indolethylamine N-methyltransferase

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of INMT protein]

NCBI chr 4:85,648,459...85,652,755
Ensembl chr 4:85,648,459...85,652,755

G

keratin 8

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of KRT8 protein]

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

lipocalin 2

multiple interactions

ISO

[1-aminobenzotriazole co-treated with ochratoxin A] results in increased expression of LCN2 protein

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

regucalcin

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of RGN protein]

NCBI chr X:4,172,537...4,190,112
Ensembl chr X:4,172,537...4,190,251

G

sulfotransferase family 1A member 1

multiple interactions

ISO

1-aminobenzotriazole inhibits the reaction [[[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 1-methylpyrene] which results in increased mutagenesis of HPRT1 gene]

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

upstream binding protein 1

multiple interactions

ISO

1-aminobenzotriazole affects the reaction [propylene dichloride results in decreased expression of UBP1 protein]

NCBI chr 8:122,748,005...122,793,824
Ensembl chr 8:122,748,049...122,793,824

8-(3-chlorostyryl)caffeine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine A2a receptor

multiple interactions
increases response to substance

EXP
ISO

8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein]
ADORA2A protein results in increased susceptibility to 8-(3-chlorostyryl)caffeine

PMID:11172060 PMID:15641640 PMID:18608257 PMID:19966059 PMID:21195062

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802

G

dopamine receptor D2

affects response to substance
multiple interactions

ISO

DRD2 protein affects the susceptibility to 8-(3-chlorostyryl)caffeine
DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]]

PMID:8577368 PMID:10199625

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

natriuretic peptide A

multiple interactions

EXP

8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

neurotensin

multiple interactions

EXP

8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA]

NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

multiple interactions

ISO

pimagedine inhibits the reaction [Paraquat results in decreased activity of ACE protein]

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

advanced glycosylation end product-specific receptor

multiple interactions

ISO

pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]

PMID:26723916 PMID:29148590

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685

G

allograft inflammatory factor 1

multiple interactions

EXP

pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein]

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339

G

albumin

multiple interactions

ISO
EXP

pimagedine inhibits the reaction [[Fructose co-treated with Glucose] results in increased glycation of ALB protein]; pimagedine inhibits the reaction [[Peroxynitrous Acid co-treated with Glucose] results in increased glycation of ALB protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased glycation of ALB protein]
pimagedine inhibits the reaction [Doxorubicin results in increased expression of ALB protein]

PMID:12196478 PMID:22287321 PMID:36933777 PMID:38372178

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

amine oxidase, copper containing 1

multiple interactions
decreases activity

ISO
EXP

pimagedine inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
pimagedine inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]
pimagedine results in decreased activity of AOC1 protein

PMID:6218830 PMID:8144586

NCBI chr 4:79,143,126...79,162,705
Ensembl chr 4:79,143,126...79,162,704

G

amyloid beta precursor protein

multiple interactions

ISO

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

ATPase plasma membrane Ca2+ transporting 1

decreases expression

EXP

pimagedine results in decreased expression of ATP2B1 mRNA

NCBI chr 7:35,622,267...35,731,904
Ensembl chr 7:35,622,461...35,731,904

G

beta-secretase 1

multiple interactions

ISO

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]

NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918

G

BCL2 associated X, apoptosis regulator

decreases expression

ISO

pimagedine results in decreased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

[pimagedine results in decreased activity of NOS2 protein] which results in decreased expression of BCL2 mRNA; pimagedine inhibits the reaction [Cardiotoxins results in increased phosphorylation of BCL2 protein]
[pimagedine results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein] which results in increased susceptibility to Chromates; pimagedine inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]; pimagedine results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein

PMID:16980304 PMID:17135264 PMID:17786558

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

calcitonin-related polypeptide alpha

multiple interactions

EXP

pimagedine inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

caspase 3

multiple interactions

EXP
ISO

pimagedine inhibits the reaction [Estradiol results in increased activity of CASP3 protein]
pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]

PMID:15545282 PMID:33930484

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

multiple interactions

ISO

pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 9

multiple interactions

ISO

pimagedine inhibits the reaction [Cardiotoxins results in increased cleavage of CASP9 protein]
pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP9 protein]; pimagedine promotes the reaction [chromium hexavalent ion results in increased activity of CASP9 protein]; pimagedine promotes the reaction [sodium bichromate results in increased activity of CASP9 protein]

PMID:17786558 PMID:19556603 PMID:33930484

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases expression

EXP
ISO

[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; pimagedine inhibits the reaction [Cyclophosphamide results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]
pimagedine results in decreased expression of CAT protein

PMID:12123627 PMID:19107871 PMID:19266598 PMID:19481068 PMID:22287321

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

caveolin 1

decreases expression

ISO

pimagedine results in decreased expression of CAV1 protein

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740

G

CD34 molecule

decreases expression

ISO

pimagedine results in decreased expression of CD34 protein

NCBI chr13:109,008,786...109,029,317
Ensembl chr13:109,008,623...109,029,315

G

CF transmembrane conductance regulator

multiple interactions

ISO

pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR mRNA]; pimagedine inhibits the reaction [Ozone results in decreased expression of CFTR protein]

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

collagen type I alpha 1 chain

increases expression

EXP

pimagedine results in increased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

cAMP responsive element binding protein 1

decreases phosphorylation

ISO

pimagedine results in decreased phosphorylation of CREB1 protein

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

C-X-C motif chemokine receptor 2

multiple interactions

ISO

[pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein

NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602

G

cytochrome b-245 alpha chain

multiple interactions

EXP

pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

ISO

pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]

NCBI chr 1:90,780,468...90,859,852

G

endothelin 1

multiple interactions

EXP

pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

endothelin receptor type A

multiple interactions

EXP

pimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284

G

Fc epsilon receptor II

multiple interactions

ISO

pimagedine inhibits the reaction [FCER2 protein results in increased expression of IL1B protein]

NCBI chr12:6,540,697...6,552,364
Ensembl chr12:6,540,703...6,549,374

G

flavin containing dimethylaniline monoxygenase 1

multiple interactions

EXP

pimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in decreased expression of FMO1 protein]

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

glutamate cysteine ligase, modifier subunit

multiple interactions

ISO

pimagedine inhibits the reaction [Spermidine results in increased expression of GCLM mRNA]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glial fibrillary acidic protein

multiple interactions

EXP

[7-nitroindazole co-treated with pimagedine] promotes the reaction [Capsaicin results in increased expression of GFAP protein]; [7-nitroindazole co-treated with pimagedine] results in increased expression of GFAP protein; pimagedine inhibits the reaction [Capsaicin results in increased expression of GFAP protein]

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

glyoxalase 1

multiple interactions

ISO
EXP

pimagedine inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]
pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of GLO1 protein]

PMID:26723916 PMID:28919305 PMID:29148590 PMID:33930484

NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,665,061...8,683,191

G

glutamic--pyruvic transaminase

multiple interactions

EXP

pimagedine inhibits the reaction [sodium arsenite results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

multiple interactions

EXP

pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione S-transferase alpha 2

multiple interactions

ISO

pimagedine inhibits the reaction [Spermidine results in increased expression of GSTA1 mRNA]

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092

G

glutathione S-transferase mu 1

multiple interactions

ISO

pimagedine inhibits the reaction [Spermidine results in increased expression of GSTM1 mRNA]

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ISO

pimagedine inhibits the reaction [titanium dioxide results in increased expression of HIF1A protein]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

heme oxygenase 1

multiple interactions

ISO

pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]
pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 mRNA]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]

PMID:29148590 PMID:33930484

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

interferon gamma

multiple interactions

ISO
EXP

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Lipopolysaccharides promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]]
pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]
pimagedine inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]

PMID:7689037 PMID:11498278 PMID:12612912 PMID:12892526 PMID:12911628 More...

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 beta

multiple interactions

ISO
EXP

pimagedine inhibits the reaction [Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; pimagedine inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; pimagedine inhibits the reaction [FCER2 protein results in increased expression of IL1B protein]
pimagedine inhibits the reaction [titanium dioxide results in increased expression of IL1B mRNA]
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of IL1B protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein]; pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein]

PMID:9698594 PMID:11500085 PMID:12123627 PMID:25406100 PMID:28223158 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO
EXP

pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein]

PMID:25042521 PMID:26723916 PMID:28223158 PMID:29148590

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

mitogen activated protein kinase 1

multiple interactions

EXP

pimagedine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

EXP

pimagedine results in decreased phosphorylation of and results in decreased activity of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

marker of proliferation Ki-67

decreases expression

ISO

pimagedine results in decreased expression of MKI67 mRNA

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

matrix metallopeptidase 13

increases expression

EXP

pimagedine results in increased expression of MMP13 mRNA

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 14

increases expression

EXP

pimagedine results in increased expression of MMP14 mRNA

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893

G

matrix metallopeptidase 9

multiple interactions

EXP

pimagedine inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

multiple interactions

EXP

pimagedine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; pimagedine promotes the reaction [Indomethacin results in increased activity of MPO protein]

PMID:11713966 PMID:18209962

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mitochondrially encoded cytochrome c oxidase I

affects activity
affects expression

EXP

pimagedine affects the activity of COX1 protein
pimagedine affects the expression of COX1 mRNA

NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

pimagedine inhibits the reaction [Pyruvaldehyde affects the localization of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nitric oxide synthase 1

affects expression

EXP

pimagedine affects the expression of NOS1 mRNA

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nitric oxide synthase 2

decreases expression
affects expression
decreases activity
multiple interactions

ISO
EXP

pimagedine results in decreased expression of NOS2 protein
pimagedine affects the expression of NOS2 mRNA; pimagedine affects the expression of NOS2 protein
pimagedine results in decreased expression of NOS2 mRNA; pimagedine results in decreased expression of NOS2 protein
pimagedine results in decreased activity of NOS2 protein
[pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in decreased secretion of Nitrites; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in increased secretion of Dihydrotestosterone; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in increased secretion of Testosterone; pimagedine inhibits the reaction [Acrolein results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [Sodium Selenite results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Sodium Selenite results in increased expression of NOS2 protein]; pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]
[pimagedine results in decreased activity of NOS2 protein] which results in decreased expression of BCL2 mRNA; [pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]; pimagedine inhibits the reaction [titanium dioxide results in increased expression of NOS2 protein]; TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]]

PMID:9306416 PMID:9810145 PMID:9853001 PMID:11574821 PMID:12054156 More...

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

affects expression
multiple interactions

ISO

pimagedine affects the expression of NOS3 mRNA
pimagedine inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of NOS3 protein]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

pimagedine inhibits the reaction [Spermidine results in increased activity of NQO1 protein]; pimagedine inhibits the reaction [Spermidine results in increased expression of NQO1 mRNA]; pimagedine inhibits the reaction [Spermine results in increased activity of NQO1 protein]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

pimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

plasminogen activator, tissue type

multiple interactions

ISO

pimagedine inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein]

NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696

G

PPARG coactivator 1 alpha

multiple interactions

ISO
EXP

[Pyruvaldehyde co-treated with pimagedine] results in increased expression of PPARGC1A protein
[pimagedine co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein

PMID:26723916 PMID:28919305

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

presenilin 1

multiple interactions

ISO

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]

NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189

G

presenilin 2

multiple interactions

ISO

pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]

NCBI chr13:94,499,451...94,528,419
Ensembl chr13:94,499,928...94,525,116

G

prostaglandin-endoperoxide synthase 2

multiple interactions

EXP

pimagedine inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]; pimagedine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]; pimagedine results in decreased activity of and results in decreased expression of PTGS2 protein

PMID:15067210 PMID:17637181 PMID:29935243

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

pimagedine inhibits the reaction [Methotrexate results in increased expression of and affects the localization of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

S100 calcium binding protein B

multiple interactions

EXP

pimagedine inhibits the reaction [Streptozocin results in decreased expression of S100B protein]; pimagedine inhibits the reaction [Streptozocin results in increased expression of S100B protein]

NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081

G

serpin family E member 1

multiple interactions
increases expression

ISO
EXP

pimagedine inhibits the reaction [LPA protein modified form results in increased expression of SERPINE1 protein]
pimagedine results in increased expression of SERPINE1 mRNA

PMID:10856522 PMID:18380797

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

sirtuin 1

multiple interactions

EXP

[pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

superoxide dismutase 1

decreases expression
multiple interactions

ISO

pimagedine results in decreased expression of SOD1 protein
pimagedine inhibits the reaction [Pyruvaldehyde results in decreased expression of SOD1 mRNA]

PMID:19266598 PMID:33930484

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions
decreases expression

ISO

pimagedine inhibits the reaction [Glucose results in decreased expression of SOD2 protein]
pimagedine results in decreased expression of SOD2 protein

PMID:18483403 PMID:19266598

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

signal transducer and activator of transcription 1

multiple interactions

ISO

pimagedine inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

transforming growth factor, beta 1

increases expression
multiple interactions

EXP
ISO

pimagedine results in increased expression of TGFB1 mRNA
pimagedine inhibits the reaction [titanium dioxide results in increased expression of TGFB1 mRNA]

PMID:18380797 PMID:25406100

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tyrosine hydroxylase

multiple interactions

ISO

pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

TIMP metallopeptidase inhibitor 1

increases expression

EXP

pimagedine results in increased expression of TIMP1 mRNA

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

tumor necrosis factor

multiple interactions

ISO
EXP

pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; pimagedine inhibits the reaction [titanium dioxide results in increased expression of TNF mRNA]
[pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of TNF protein]; pimagedine inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein]

PMID:12123627 PMID:12612912 PMID:22287321 PMID:25042521 PMID:25406100 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 1A

multiple interactions

ISO

TNFRSF1A protein affects the reaction [pimagedine inhibits the reaction [NOS2 protein results in increased susceptibility to Acetaminophen]]

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

UDP glucuronosyltransferase family 2 member B7

multiple interactions

ISO

pimagedine inhibits the reaction [UGT2B7 results in increased susceptibility to Clofibric Acid]

NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amyloid beta precursor protein

multiple interactions

ISO

[Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

beta-secretase 1

decreases activity

ISO

Azure B results in decreased activity of BACE1 protein

NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 5

increases expression

ISO

Clorgyline results in increased expression of ABCA5 mRNA

NCBI chr10:95,739,610...95,808,633
Ensembl chr10:95,739,610...95,808,424

G

acyl-CoA dehydrogenase, short/branched chain

increases expression

ISO

Clorgyline results in increased expression of ACADSB mRNA

NCBI chr 1:195,619,088...195,660,564
Ensembl chr 1:195,619,038...195,660,561

G

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

increases expression

ISO

Clorgyline results in increased expression of ACAP2 mRNA

NCBI chr11:83,043,442...83,159,105
Ensembl chr11:83,043,511...83,159,107

G

actin alpha 2, smooth muscle

multiple interactions

ISO

[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of ACTA2 mRNA]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

adrenoceptor beta 2

increases expression

ISO

Clorgyline results in increased expression of ADRB2 mRNA

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

A-kinase anchoring protein 11

increases expression

ISO

Clorgyline results in increased expression of AKAP11 mRNA

NCBI chr15:60,320,839...60,365,480
Ensembl chr15:60,320,839...60,365,335

G

A-kinase anchoring protein 9

increases expression

ISO

Clorgyline results in increased expression of AKAP9 mRNA

NCBI chr 4:31,011,475...31,147,338
Ensembl chr 4:31,011,475...31,147,338

G

ankyrin repeat domain 12

increases expression

ISO

Clorgyline results in increased expression of ANKRD12 mRNA

NCBI chr 9:113,030,127...113,134,816
Ensembl chr 9:113,030,919...113,134,762

G

APC regulator of WNT signaling pathway

increases expression

ISO

Clorgyline results in increased expression of APC mRNA

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022

G

androgen receptor

increases expression

ISO

Clorgyline results in increased expression of AR mRNA

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

increases expression

ISO

Clorgyline results in increased expression of ARAP2 mRNA

NCBI chr14:50,921,323...51,120,972
Ensembl chr14:50,921,713...51,120,962

G

AT-rich interaction domain 4A

increases expression

ISO

Clorgyline results in increased expression of ARID4A mRNA

NCBI chr 6:95,258,429...95,335,987
Ensembl chr 6:95,258,429...95,329,840

G

autophagy related 4C, cysteine peptidase

increases expression

ISO

Clorgyline results in increased expression of ATG4C mRNA

NCBI chr 5:118,977,594...119,050,894
Ensembl chr 5:118,982,918...119,052,695

G

ATRX, chromatin remodeler

increases expression

ISO

Clorgyline results in increased expression of ATRX mRNA

NCBI chr X:74,916,548...75,062,880
Ensembl chr X:74,916,548...75,062,880

G

5-azacytidine induced 2

increases expression

ISO

Clorgyline results in increased expression of AZI2 mRNA

NCBI chr 8:126,651,268...126,674,795
Ensembl chr 8:126,651,206...126,676,182

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

increases expression

ISO

Clorgyline results in increased expression of B3GNT5 mRNA

NCBI chr11:94,645,480...94,657,584
Ensembl chr11:94,645,480...94,660,514

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

bromodomain adjacent to zinc finger domain, 2B

increases expression

ISO

Clorgyline results in increased expression of BAZ2B mRNA

NCBI chr 3:64,792,984...65,034,547
Ensembl chr 3:64,794,001...65,001,781

G

BCL2, apoptosis regulator

multiple interactions

ISO

Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BDP1 general transcription factor IIIB subunit

increases expression

ISO

Clorgyline results in increased expression of BDP1 mRNA

NCBI chr 2:33,112,518...33,204,270
Ensembl chr 2:33,112,518...33,204,241

G

biorientation of chromosomes in cell division 1-like 1

increases expression

ISO

Clorgyline results in increased expression of BOD1L1 mRNA

NCBI chr14:73,320,880...73,375,662
Ensembl chr14:73,320,832...73,375,658

G

bromodomain and WD repeat domain containing 1

increases expression

ISO

Clorgyline results in increased expression of BRWD1 mRNA

NCBI chr11:48,756,174...48,853,692
Ensembl chr11:48,756,811...48,848,256

G

calcium voltage-gated channel auxiliary subunit beta 2

increases expression

ISO

Clorgyline results in increased expression of CACNB2 mRNA

NCBI chr17:82,473,097...82,818,564
Ensembl chr17:82,473,129...82,818,564

G

caspase 3

multiple interactions

ISO

Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

ISO

Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]

Ensembl chr 5:159,391,188...159,409,648

G

cerebellin 2 precursor

increases expression

ISO

Clorgyline results in increased expression of CBLN2 mRNA

NCBI chr18:82,215,210...82,222,648
Ensembl chr18:82,215,220...82,222,648

G

coiled-coil domain containing 112

increases expression

ISO

Clorgyline results in increased expression of CCDC112 mRNA

NCBI chr18:41,184,769...41,218,958
Ensembl chr18:41,184,769...41,218,958

G

cadherin-related 23

increases expression

ISO

Clorgyline results in increased expression of CDH23 mRNA

NCBI chr20:28,783,124...29,165,624
Ensembl chr20:28,783,564...29,165,332

G

centromere protein C

increases expression

ISO

Clorgyline results in increased expression of CENPC mRNA

NCBI chr14:22,342,910...22,401,522
Ensembl chr14:22,342,927...22,438,590

G

centrosomal protein 135

increases expression

ISO

Clorgyline results in increased expression of CEP135 mRNA

NCBI chr14:31,884,774...31,950,050
Ensembl chr14:31,884,781...31,950,050

G

centrosomal protein 290

increases expression

ISO

Clorgyline results in increased expression of CEP290 mRNA

NCBI chr 7:37,196,765...37,285,955
Ensembl chr 7:37,196,783...37,285,955

G

centrosomal protein 350

increases expression

ISO

Clorgyline results in increased expression of CEP350 mRNA

NCBI chr13:70,573,597...70,714,673
Ensembl chr13:70,573,597...70,714,673

G

centrosomal protein 70

increases expression

ISO

Clorgyline results in increased expression of CEP70 mRNA

NCBI chr 8:108,689,562...108,742,620
Ensembl chr 8:108,689,671...108,742,617

G

complement factor H

increases expression

ISO

Clorgyline results in increased expression of CFH mRNA

NCBI chr13:54,063,079...54,164,523
Ensembl chr13:54,062,531...54,164,532

G

chromodomain helicase DNA binding protein 9

increases expression

ISO

Clorgyline results in increased expression of CHD9 mRNA

NCBI chr19:32,114,379...32,337,488
Ensembl chr19:32,115,920...32,319,042

G

cysteine-rich hydrophobic domain 1

increases expression

ISO

Clorgyline results in increased expression of CHIC1 mRNA

NCBI chr X:72,427,851...72,471,924
Ensembl chr X:72,427,851...72,471,924

G

CHM Rab escort protein

increases expression

ISO

Clorgyline results in increased expression of CHM mRNA

NCBI chr X:82,395,463...82,554,249
Ensembl chr X:82,396,816...82,568,642

G

calmegin

increases expression

ISO

Clorgyline results in increased expression of CLGN mRNA

NCBI chr19:41,601,568...41,633,207
Ensembl chr19:41,601,568...41,633,325

G

CAP-GLY domain containing linker protein 1

increases expression

ISO

Clorgyline results in increased expression of CLIP1 mRNA

NCBI chr12:38,571,533...38,678,779
Ensembl chr12:38,571,834...38,678,779

G

contactin 3

increases expression

ISO

Clorgyline results in increased expression of CNTN3 mRNA

NCBI chr 4:136,397,575...136,770,765
Ensembl chr 4:136,398,572...136,770,717

G

cordon-bleu WH2 repeat protein-like 1

increases expression

ISO

Clorgyline results in increased expression of COBLL1 mRNA

NCBI chr 3:70,161,369...70,324,844
Ensembl chr 3:70,161,372...70,323,460

G

collagen type I alpha 1 chain

multiple interactions

ISO

[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type III alpha 1 chain

multiple interactions

ISO

[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

carboxypeptidase D

increases expression

ISO

Clorgyline results in increased expression of CPD mRNA

NCBI chr10:62,121,681...62,185,638
Ensembl chr10:62,121,679...62,185,638

G

copine family member 9

increases expression

ISO

Clorgyline results in increased expression of CPNE9 mRNA

NCBI chr 4:147,985,900...148,009,987
Ensembl chr 4:147,986,452...148,009,986

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases activity
multiple interactions

ISO

Clorgyline results in decreased activity of CYP2B6 protein
Clorgyline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]

NCBI chr 1:90,780,468...90,859,852

G

dickkopf like acrosomal protein 1

increases expression

ISO

Clorgyline results in increased expression of DKKL1 mRNA

NCBI chr 1:104,830,462...104,835,711
Ensembl chr 1:104,829,478...104,835,711

G

Dmx-like 1

increases expression

ISO

Clorgyline results in increased expression of DMXL1 mRNA

NCBI chr18:45,179,505...45,349,999
Ensembl chr18:45,179,551...45,356,406

G

DnaJ heat shock protein family (Hsp40) member C10

increases expression

ISO

Clorgyline results in increased expression of DNAJC10 mRNA

NCBI chr 3:85,636,890...85,679,620
Ensembl chr 3:85,639,589...85,689,368

G

dynamin 1-like

multiple interactions

ISO

Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

dystonin

increases expression

ISO

Clorgyline results in increased expression of DST mRNA

NCBI chr 9:43,631,716...44,025,535
Ensembl chr 9:43,631,517...44,025,533

G

dynein cytoplasmic 2 heavy chain 1

increases expression

ISO

Clorgyline results in increased expression of DYNC2H1 mRNA

NCBI chr 8:12,473,955...12,697,075
Ensembl chr 8:12,473,955...12,697,058

G

dynein cytoplasmic 2 light intermediate chain 1

increases expression

ISO

Clorgyline results in increased expression of DYNC2LI1 mRNA

NCBI chr 6:15,745,350...15,778,166
Ensembl chr 6:15,745,350...15,778,166

G

ethylmalonyl-CoA decarboxylase 1

increases expression

ISO

Clorgyline results in increased expression of ECHDC1 mRNA

NCBI chr 1:30,304,968...30,355,957
Ensembl chr 1:30,304,971...30,337,208

G

establishment of sister chromatid cohesion N-acetyltransferase 1

increases expression

ISO

Clorgyline results in increased expression of ESCO1 mRNA

NCBI chr18:1,904,748...1,959,609
Ensembl chr18:1,904,762...1,959,805

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

ISO

Clorgyline results in decreased expression of EZH2 mRNA

NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:77,624,223...77,687,183

G

Fas cell surface death receptor

increases expression

ISO

Clorgyline results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

fission, mitochondrial 1

multiple interactions

ISO

Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

frizzled class receptor 3

increases expression

ISO

Clorgyline results in increased expression of FZD3 mRNA

NCBI chr15:43,596,962...43,664,047
Ensembl chr15:43,596,965...43,663,960

G

GA binding protein transcription factor subunit alpha

increases expression

ISO

Clorgyline results in increased expression of GABPA mRNA

NCBI chr11:37,375,040...37,404,060
Ensembl chr11:37,375,084...37,404,059

G

growth associated protein 43

decreases expression

EXP

Clorgyline results in decreased expression of GAP43 protein

NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797

G

GRIP and coiled-coil domain containing 2

increases expression

ISO

Clorgyline results in increased expression of GCC2 mRNA

NCBI chr20:26,788,472...26,836,728
Ensembl chr20:26,790,516...26,836,726

G

glycerol kinase

increases expression

ISO

Clorgyline results in increased expression of GK mRNA

NCBI chr X:54,106,708...54,189,940
Ensembl chr X:54,112,214...54,196,701

G

glucosamine-6-phosphate deaminase 2

increases expression

ISO

Clorgyline results in increased expression of GNPDA2 mRNA

NCBI chr14:38,874,611...38,892,688
Ensembl chr14:38,874,647...38,892,683

G

golgin A4

increases expression

ISO

Clorgyline results in increased expression of GOLGA4 mRNA

NCBI chr 8:127,085,830...127,163,227
Ensembl chr 8:127,085,848...127,163,603

G

golgin B1

increases expression

ISO

Clorgyline results in increased expression of GOLGB1 mRNA

NCBI chr11:77,348,573...77,406,165
Ensembl chr11:77,348,961...77,406,006

G

hemoglobin, beta adult major chain

increases expression

ISO

Clorgyline results in increased expression of HBD mRNA

NCBI chr 1:167,636,064...167,643,577

G

histidine triad nucleotide binding protein 3

increases expression

ISO

Clorgyline results in increased expression of HINT3 mRNA

NCBI chr 1:28,854,860...28,864,723
Ensembl chr 1:28,854,844...28,867,125

G

inhibitor of Bruton tyrosine kinase

increases expression

ISO

Clorgyline results in increased expression of IBTK mRNA

NCBI chr 8:95,505,630...95,579,435
Ensembl chr 8:95,505,630...95,578,301

G

intraflagellar transport 80

increases expression

ISO

Clorgyline results in increased expression of IFT80 mRNA

NCBI chr 2:155,455,773...155,550,082
Ensembl chr 2:155,455,774...155,550,275

G

interleukin 1 beta

multiple interactions

ISO

Clorgyline inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

kelch domain containing 1

increases expression

ISO

Clorgyline results in increased expression of KLHDC1 mRNA

NCBI chr 6:93,406,226...93,501,475
Ensembl chr 6:93,448,758...93,501,702

G

kelch-like family member 2

increases expression

ISO

Clorgyline results in increased expression of KLHL2 mRNA

NCBI chr16:29,627,171...29,739,782
Ensembl chr16:29,627,237...29,739,957

G

kallikrein 1-related peptidase C10

increases expression

ISO

Clorgyline results in increased expression of KLK3 mRNA

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586

G

kinectin 1

increases expression

ISO

Clorgyline results in increased expression of KTN1 mRNA

NCBI chr15:23,392,570...23,485,061
Ensembl chr15:23,394,315...23,482,263

G

La ribonucleoprotein 1B

increases expression

ISO

Clorgyline results in increased expression of LARP1B mRNA

NCBI chr 2:125,860,935...125,897,189
Ensembl chr 2:125,863,997...125,897,189

G

DNA ligase 4

increases expression

ISO

Clorgyline results in increased expression of LIG4 mRNA

NCBI chr16:86,220,345...86,228,930
Ensembl chr16:86,220,279...86,229,926

G

lecithin retinol acyltransferase

increases expression

ISO

Clorgyline results in increased expression of LRAT mRNA

NCBI chr 2:170,562,148...170,571,212
Ensembl chr 2:170,565,543...170,571,148

G

lymphotoxin beta

increases expression

ISO

Clorgyline results in increased expression of LTB mRNA

NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,632,210...3,634,054

G

mannosidase, endo-alpha

increases expression

ISO

Clorgyline results in increased expression of MANEA mRNA

NCBI chr 5:44,992,937...45,015,084
Ensembl chr 5:44,992,937...45,015,084

G

monoamine oxidase A

multiple interactions
decreases activity

ISO
EXP

[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; [Clorgyline results in decreased activity of MAOA protein] which results in increased susceptibility to Methamphetamine
Clorgyline inhibits the reaction [MAOA protein results in increased degradation of Serotonin]
Phenylpropanolamine inhibits the reaction [Clorgyline results in decreased activity of MAOA protein]

PMID:1905457 PMID:3961266 PMID:12818349 PMID:16252076 PMID:21923181 More...

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

decreases activity
multiple interactions

ISO

Clorgyline results in decreased activity of MAOB protein
[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]

PMID:23499958 PMID:23943324

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

microtubule-associated protein 9

increases expression

ISO

Clorgyline results in increased expression of MAP9 mRNA

NCBI chr 2:170,005,792...170,042,003
Ensembl chr 2:170,006,834...170,042,001

G

muscleblind-like splicing regulator 2

increases expression

ISO

Clorgyline results in increased expression of MBNL2 mRNA

NCBI chr15:103,792,134...103,949,827
Ensembl chr15:103,792,152...103,949,827

G

mitofusin 1

multiple interactions

ISO

Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190

G

MIA SH3 domain ER export factor 2

increases expression

ISO

Clorgyline results in increased expression of MIA2 mRNA

NCBI chr 6:82,522,398...82,620,136
Ensembl chr 6:82,522,422...82,620,178

G

mirror-image polydactyly 1

increases expression

ISO

Clorgyline results in increased expression of MIPOL1 mRNA

NCBI chr 6:80,490,330...80,825,413
Ensembl chr 6:80,490,312...80,825,413

G

MOB kinase activator 1B

increases expression

ISO

Clorgyline results in increased expression of MOB1B mRNA

NCBI chr14:19,617,136...19,649,919
Ensembl chr14:19,610,445...19,649,919

G

MON2 homolog, regulator of endosome-to-Golgi trafficking

increases expression

ISO

Clorgyline results in increased expression of MON2 mRNA

NCBI chr 7:60,534,772...60,613,467
Ensembl chr 7:60,534,772...60,613,467

G

motile sperm domain containing 2

increases expression

ISO

Clorgyline results in increased expression of MOSPD2 mRNA

NCBI chr X:33,052,063...33,105,550
Ensembl chr X:33,052,004...33,107,635

G

MAGUK p55 scaffold protein 7

increases expression

ISO

Clorgyline results in increased expression of MPP7 mRNA

NCBI chr17:60,135,096...60,401,814
Ensembl chr17:60,137,701...60,401,739

G

mitochondrially encoded ATP synthase membrane subunit 6

multiple interactions

ISO

Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]

NCBI chr MT:7,919...8,599
Ensembl chr MT:7,904...8,584

G

mitochondrially encoded cytochrome b

multiple interactions

ISO

Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]

NCBI chr MT:14,136...15,278
Ensembl chr MT:14,124...15,266

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

multiple interactions

ISO

Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]

NCBI chr MT:2,740...3,694
Ensembl chr MT:2,729...3,685

G

myosin VI

increases expression

ISO

Clorgyline results in increased expression of MYO6 mRNA

NCBI chr 8:89,967,351...90,122,219
Ensembl chr 8:89,967,377...90,122,215

G

Nedd4 family interacting protein 2

increases expression

ISO

Clorgyline results in increased expression of NDFIP2 mRNA

NCBI chr15:88,394,548...88,500,881
Ensembl chr15:88,395,032...88,503,600

G

NFE2 like bZIP transcription factor 2

increases expression

ISO

Clorgyline results in increased expression of NFE2L2 mRNA

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NIPBL, cohesin loading factor

increases expression

ISO

Clorgyline results in increased expression of NIPBL mRNA

NCBI chr 2:59,126,676...59,314,841
Ensembl chr 2:59,126,676...59,293,277

G

nuclear protein, co-activator of histone transcription

increases expression

ISO

Clorgyline results in increased expression of NPAT mRNA

NCBI chr 8:62,829,141...62,867,065
Ensembl chr 8:62,829,185...62,867,065

G

nuclear receptor subfamily 1, group I, member 2

increases activity

ISO

Clorgyline results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor interacting protein 1

increases expression

ISO

Clorgyline results in increased expression of NRIP1 mRNA

NCBI chr11:28,382,835...28,466,483
Ensembl chr11:28,378,878...28,467,353

G

nuclear speckle splicing regulatory protein 1

increases expression

ISO

Clorgyline results in increased expression of NSRP1 mRNA

NCBI chr10:62,378,937...62,412,601
Ensembl chr10:62,378,955...62,412,601

G

NOP2/Sun RNA methyltransferase 3

increases expression

ISO

Clorgyline results in increased expression of NSUN3 mRNA

NCBI chr11:50,960,187...51,062,366
Ensembl chr11:50,960,192...51,045,220

G

5'-nucleotidase domain containing 1

increases expression

ISO

Clorgyline results in increased expression of NT5DC1 mRNA

NCBI chr20:39,660,707...39,763,647
Ensembl chr20:39,660,707...39,786,449

G

NudC domain containing 1

increases expression

ISO

Clorgyline results in increased expression of NUDCD1 mRNA

NCBI chr 7:77,436,035...77,480,651
Ensembl chr 7:77,436,036...77,480,575

G

outer dense fiber of sperm tails 2-like

increases expression

ISO

Clorgyline results in increased expression of ODF2L mRNA

NCBI chr 2:236,696,158...236,733,090
Ensembl chr 2:236,696,389...236,733,086

G

pericentriolar material 1

increases expression

ISO

Clorgyline results in increased expression of PCM1 mRNA

NCBI chr16:57,711,833...57,808,842
Ensembl chr16:57,711,833...57,808,599

G

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1

increases expression

ISO

Clorgyline results in increased expression of PCMTD1 mRNA

NCBI chr 5:17,071,629...17,143,803
Ensembl chr 5:17,071,629...17,142,010

G

PDLIM1 interacting kinase 1 like

increases expression

ISO

Clorgyline results in increased expression of PDIK1L mRNA

NCBI chr 5:151,778,813...151,793,137
Ensembl chr 5:151,778,837...151,790,557

G

PHD finger protein 14

increases expression

ISO

Clorgyline results in increased expression of PHF14 mRNA

NCBI chr 4:40,975,897...41,162,043
Ensembl chr 4:40,975,439...41,162,043

G

PHD finger protein 3

increases expression

ISO

Clorgyline results in increased expression of PHF3 mRNA

NCBI chr 9:40,559,929...40,632,096
Ensembl chr 9:40,559,929...40,632,056

G

pleckstrin homology domain interacting protein

increases expression

ISO

Clorgyline results in increased expression of PHIP mRNA

NCBI chr 8:92,656,890...92,771,098
Ensembl chr 8:92,656,890...92,771,021

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

increases expression

ISO

Clorgyline results in increased expression of PIK3C2A mRNA

NCBI chr 1:180,012,248...180,117,786
Ensembl chr 1:180,012,248...180,117,773

G

DNA polymerase kappa

increases expression

ISO

Clorgyline results in increased expression of POLK mRNA

NCBI chr 2:29,556,831...29,616,960
Ensembl chr 2:29,557,336...29,616,960

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

multiple interactions

ISO

[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]

NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,844,036...83,853,063

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

increases expression

ISO

Clorgyline results in increased expression of PREX2 mRNA

NCBI chr 5:12,720,683...13,036,077
Ensembl chr 5:12,720,683...13,057,881

G

proline dehydrogenase 2

increases expression

ISO

Clorgyline results in increased expression of PRODH2 mRNA

NCBI chr 1:94,881,000...94,894,609
Ensembl chr 1:94,881,061...94,894,609

G

protein tyrosine phosphatase, non-receptor type 22

increases expression

ISO

Clorgyline results in increased expression of PTPN22 mRNA

NCBI chr 2:194,055,165...194,103,209
Ensembl chr 2:194,045,746...194,103,209

G

RAD50 double strand break repair protein

increases expression

ISO

Clorgyline results in increased expression of RAD50 mRNA

NCBI chr10:38,310,147...38,362,100
Ensembl chr10:38,310,147...38,362,100

G

RAD54 homolog B

increases expression

ISO

Clorgyline results in increased expression of RAD54B mRNA

NCBI chr 5:29,829,465...29,901,967
Ensembl chr 5:29,855,304...29,901,964

G

Rap guanine nucleotide exchange factor 4

increases expression

ISO

Clorgyline results in increased expression of RAPGEF4 mRNA

NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:77,217,039...77,509,978

G

RB1-inducible coiled-coil 1

increases expression

ISO

Clorgyline results in increased expression of RB1CC1 mRNA

NCBI chr 5:17,948,522...18,012,434
Ensembl chr 5:17,948,522...18,012,434

G

REV3 like, DNA directed polymerase zeta catalytic subunit

increases expression

ISO

Clorgyline results in increased expression of REV3L mRNA

NCBI chr20:44,686,482...44,844,668
Ensembl chr20:44,686,940...44,844,668

G

regulator of G-protein signaling 5

increases expression

ISO

Clorgyline results in increased expression of RGS5 mRNA

NCBI chr13:84,381,077...84,417,875
Ensembl chr13:84,380,910...84,421,352

G

RPTOR independent companion of MTOR, complex 2

increases expression

ISO

Clorgyline results in increased expression of RICTOR mRNA

NCBI chr 2:57,539,279...57,631,291
Ensembl chr 2:57,539,311...57,631,288

G

sterile alpha motif domain containing 9

increases expression

ISO

Clorgyline results in increased expression of SAMD9 mRNA

NCBI chr 4:32,119,318...32,139,008
Ensembl chr 4:32,117,137...32,171,759

G

SR-related CTD-associated factor 11

increases expression

ISO

Clorgyline results in increased expression of SCAF11 mRNA

NCBI chr 7:129,450,872...129,503,280
Ensembl chr 7:129,417,955...129,503,280

G

selenoprotein P

increases expression

ISO

Clorgyline results in increased expression of SELENOP mRNA

NCBI chr 2:54,225,736...54,236,022
Ensembl chr 2:54,225,152...54,236,019

G

semaphorin 3C

increases expression

ISO

Clorgyline results in increased expression of SEMA3C mRNA

NCBI chr 4:18,538,452...18,702,453
Ensembl chr 4:18,538,454...18,701,740

G

SUMO specific peptidase 6

increases expression

ISO

Clorgyline results in increased expression of SENP6 mRNA

NCBI chr 8:89,868,115...89,951,803
Ensembl chr 8:89,868,867...89,948,062

G

SUMO specific peptidase 7

increases expression

ISO

Clorgyline results in increased expression of SENP7 mRNA

NCBI chr11:57,892,801...58,053,213
Ensembl chr11:57,787,914...58,033,766

G

SHOC2 leucine-rich repeat scaffold protein

increases expression

ISO

Clorgyline results in increased expression of SHOC2 mRNA

NCBI chr 1:262,964,345...263,052,898
Ensembl chr 1:262,965,011...263,052,634

G

solute carrier family 4 member 5

increases expression

ISO

Clorgyline results in increased expression of SLC4A5 mRNA

NCBI chr 4:117,267,803...117,368,024
Ensembl chr 4:117,267,822...117,368,024

G

SLIT and NTRK-like family, member 6

increases expression

ISO

Clorgyline results in increased expression of SLITRK6 mRNA

NCBI chr15:93,977,812...93,984,431
Ensembl chr15:93,969,038...93,984,526

G

STE20-like kinase

increases expression

ISO

Clorgyline results in increased expression of SLK mRNA

NCBI chr 1:256,415,013...256,470,942
Ensembl chr 1:256,415,013...256,467,829

G

structural maintenance of chromosomes flexible hinge domain containing 1

increases expression

ISO

Clorgyline results in increased expression of SMCHD1 mRNA

NCBI chr 9:118,690,050...118,837,281
Ensembl chr 9:118,690,057...118,833,452

G

small nucleolar RNA, C/D box 64

increases expression

ISO

Clorgyline results in increased expression of SNORD64 mRNA

NCBI chr 1:120,310,428...120,310,494
Ensembl chr 1:120,310,428...120,310,494

G

suppressor of cytokine signaling 2

increases expression

ISO

Clorgyline results in increased expression of SOCS2 mRNA

NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:31,874,463...31,930,423

G

STAG2 cohesin complex component

increases expression

ISO

Clorgyline results in increased expression of STAG2 mRNA

NCBI chr X:125,839,660...125,971,209
Ensembl chr X:125,840,401...125,971,209

G

signal transducer and activator of transcription 3

multiple interactions

ISO

[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased phosphorylation of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

STEAP2 metalloreductase

increases expression

ISO

Clorgyline results in increased expression of STEAP2 mRNA

NCBI chr 4:29,302,487...29,323,006
Ensembl chr 4:29,303,381...29,330,620

G

syntaxin binding protein 4

increases expression

ISO

Clorgyline results in increased expression of STXBP4 mRNA

NCBI chr10:75,798,938...75,955,817
Ensembl chr10:75,798,938...75,955,737

G

TBC1 domain family, member 15

increases expression

ISO

Clorgyline results in increased expression of TBC1D15 mRNA

NCBI chr 7:52,690,770...52,746,309
Ensembl chr 7:52,690,770...52,746,303

G

TBC1 domain family member 8B

increases expression

ISO

Clorgyline results in increased expression of TBC1D8B mRNA

NCBI chr X:108,107,796...108,195,744
Ensembl chr X:108,107,769...108,195,732

G

transcription elongation factor A like 7

increases expression

ISO

Clorgyline results in increased expression of TCEAL7 mRNA

NCBI chr X:104,020,016...104,022,176
Ensembl chr X:104,011,409...104,022,176

G

testis expressed 9

increases expression

ISO

Clorgyline results in increased expression of TEX9 mRNA

NCBI chr 8:82,049,194...82,094,613
Ensembl chr 8:82,058,514...82,094,801

G

THAP domain containing 2

increases expression

ISO

Clorgyline results in increased expression of THAP2 mRNA

NCBI chr 7:52,879,011...52,893,680
Ensembl chr 7:52,879,011...52,891,932

G

transmembrane p24 trafficking protein 5

increases expression

ISO

Clorgyline results in increased expression of TMED5 mRNA

NCBI chr14:1,752,857...1,763,990
Ensembl chr14:1,752,745...1,773,389

G

transmembrane protein 106B

increases expression

ISO

Clorgyline results in increased expression of TMEM106B mRNA

NCBI chr 4:42,294,074...42,313,426
Ensembl chr 4:42,294,101...42,313,407

G

TATA element modulatory factor 1

increases expression

ISO

Clorgyline results in increased expression of TMF1 mRNA

NCBI chr 4:131,316,630...131,345,666
Ensembl chr 4:131,311,801...131,342,436

G

tumor necrosis factor

multiple interactions

ISO

Clorgyline inhibits the reaction [Cisplatin results in increased secretion of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

thyroid hormone receptor interactor 11

increases expression

ISO

Clorgyline results in increased expression of TRIP11 mRNA

NCBI chr 6:126,760,263...126,832,619
Ensembl chr 6:126,760,265...126,832,570

G

terminal uridylyl transferase 7

increases expression

ISO

Clorgyline results in increased expression of TUT7 mRNA

NCBI chr17:4,854,553...4,908,758
Ensembl chr17:4,855,936...4,909,070

G

ubiquitin-conjugating enzyme E2W

increases expression

ISO

Clorgyline results in increased expression of UBE2W mRNA

NCBI chr 5:7,474,039...7,531,526
Ensembl chr 5:7,474,003...7,598,245

G

ubiquitin-like domain containing CTD phosphatase 1

increases expression

ISO

Clorgyline results in increased expression of UBLCP1 mRNA

NCBI chr10:29,447,081...29,462,446
Ensembl chr10:29,447,081...29,462,386

G

UPF3B, regulator of nonsense mediated mRNA decay

increases expression

ISO

Clorgyline results in increased expression of UPF3B mRNA

NCBI chr X:121,200,993...121,219,059
Ensembl chr X:121,200,993...121,218,921

G

utrophin

increases expression

ISO

Clorgyline results in increased expression of UTRN mRNA

NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:8,542,798...9,044,487

G

valosin containing protein interacting protein 1

increases expression

ISO

Clorgyline results in increased expression of VCPIP1 mRNA

NCBI chr 5:14,317,083...14,343,724
Ensembl chr 5:14,316,918...14,347,778

G

vacuolar protein sorting 13 homolog A

increases expression

ISO

Clorgyline results in increased expression of VPS13A mRNA

NCBI chr 1:223,328,784...223,555,500
Ensembl chr 1:223,328,784...223,555,331

G

vacuolar protein sorting 13 homolog C

increases expression

ISO

Clorgyline results in increased expression of VPS13C mRNA

NCBI chr 8:77,359,499...77,533,009
Ensembl chr 8:77,359,504...77,531,871

G

VPS37A subunit of ESCRT-I

increases expression

ISO

Clorgyline results in increased expression of VPS37A mRNA

NCBI chr16:58,434,802...58,478,777
Ensembl chr16:58,440,950...58,478,831

G

WD repeat domain 17

increases expression

ISO

Clorgyline results in increased expression of WDR17 mRNA

NCBI chr16:43,792,989...43,924,187
Ensembl chr16:43,792,973...43,924,184

G

zinc finger and BTB domain containing 1

increases expression

ISO

Clorgyline results in increased expression of ZBTB1 mRNA

NCBI chr 6:100,832,506...100,864,019
Ensembl chr 6:100,838,714...100,852,643

G

zinc finger and BTB domain containing 10

increases expression

ISO

Clorgyline results in increased expression of ZBTB10 mRNA

NCBI chr 2:94,382,670...94,417,308
Ensembl chr 2:94,386,400...94,417,308

G

zinc finger protein 280C

increases expression

ISO

Clorgyline results in increased expression of ZNF280C mRNA

NCBI chr X:132,594,279...132,685,548
Ensembl chr X:132,594,292...132,685,841

G

zinc finger protein 280D

increases expression

ISO

Clorgyline results in increased expression of ZNF280D mRNA

NCBI chr 8:81,872,108...81,961,194
Ensembl chr 8:81,873,335...81,961,201

G

zinc finger protein 292

increases expression

ISO

Clorgyline results in increased expression of ZNF292 mRNA

NCBI chr 5:54,184,174...54,264,454
Ensembl chr 5:54,184,174...54,304,147

G

zinc finger protein 300

increases expression

ISO

Clorgyline results in increased expression of ZNF567 mRNA

NCBI chr X:3,452,993...3,472,102
Ensembl chr X:3,454,030...3,472,084

G

zinc finger protein 449

increases expression

ISO

Clorgyline results in increased expression of ZNF449 mRNA

NCBI chr X:139,127,425...139,147,490
Ensembl chr X:139,127,479...139,147,489

G

zinc finger protein 638

increases expression

ISO

Clorgyline results in increased expression of ZNF638 mRNA

NCBI chr 4:117,913,528...118,032,644
Ensembl chr 4:117,913,545...118,032,643

G

zinc finger protein 644

increases expression

ISO

Clorgyline results in increased expression of ZNF644 mRNA

NCBI chr14:3,248,350...3,324,820
Ensembl chr14:3,249,888...3,324,820

G

zinc finger FYVE-type containing 16

increases expression

ISO

Clorgyline results in increased expression of ZFYVE16 mRNA

NCBI chr 2:25,448,264...25,495,180
Ensembl chr 2:25,448,829...25,483,295

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

ISO

Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate aminotransferase

increases expression

EXP

Eugenol results in increased expression of AADAT protein

NCBI chr16:34,520,236...34,566,388
Ensembl chr16:34,520,238...34,566,540

G

ATP binding cassette subfamily A member 6

decreases expression

ISO

Eugenol results in decreased expression of ABCA6 mRNA

NCBI chr10:95,642,026...95,711,535
Ensembl chr10:95,641,900...95,710,899

G

ATP binding cassette subfamily B member 10

increases expression

EXP

Eugenol results in increased expression of ABCB10 protein

NCBI chr19:68,850,108...68,881,689
Ensembl chr19:68,850,134...68,880,203

G

ATP binding cassette subfamily B member 1A

increases expression

EXP

Eugenol results in increased expression of ABCB1A protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 4

increases expression

EXP

Eugenol results in increased expression of ABCC4 protein

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily G member 2

increases expression

EXP

Eugenol results in increased expression of ABCG2 protein

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

abhydrolase domain containing 11

decreases expression

EXP

Eugenol results in decreased expression of ABHD11 protein

NCBI chr12:27,318,739...27,322,016
Ensembl chr12:27,318,749...27,321,970

G

ABRA C-terminal like

decreases expression

EXP

Eugenol results in decreased expression of ABRACL protein

NCBI chr 1:14,474,802...14,484,992
Ensembl chr 1:14,474,803...14,485,055

G

acetyl-CoA acyltransferase 2

increases expression

EXP

Eugenol results in increased expression of ACAA2 protein

NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420

G

acetylcholinesterase

multiple interactions

EXP

Eugenol inhibits the reaction [Chlorpyrifos results in decreased expression of ACHE protein]

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

aminocarboxymuconate semialdehyde decarboxylase

decreases expression

EXP

Eugenol results in decreased expression of ACMSD protein

NCBI chr13:41,752,894...41,798,427
Ensembl chr13:41,752,875...41,798,427

G

acyl-CoA synthetase medium-chain family member 3

decreases expression

EXP

Eugenol results in decreased expression of ACSM3 protein

NCBI chr 1:183,564,652...183,591,328
Ensembl chr 1:183,564,635...183,591,437

G

actin alpha 2, smooth muscle

increases expression

EXP

Eugenol results in increased expression of ACTA2 protein

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

actin, gamma 1

decreases expression

EXP

Eugenol results in decreased expression of ACTG1 protein

NCBI chr10:106,118,106...106,120,951
Ensembl chr10:106,118,108...106,120,951

G

actin related protein 2

increases expression

EXP

Eugenol results in increased expression of ACTR2 protein

NCBI chr14:98,500,119...98,535,092
Ensembl chr14:98,500,138...98,541,998

G

ADAM metallopeptidase domain 22

decreases expression

EXP

Eugenol results in decreased expression of ADAM22 protein

NCBI chr 4:26,670,984...26,925,843
Ensembl chr 4:26,671,112...26,925,843

G

alcohol dehydrogenase 5 (class III), chi polypeptide

decreases expression

EXP

Eugenol results in decreased expression of ADH5 protein

NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:229,648,501...229,665,232

G

aryl hydrocarbon receptor

multiple interactions
increases activity
affects localization

ISO

[Eugenol co-treated with acetyleugenol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [Eugenol co-treated with acetyleugenol] results in increased activity of AHR protein; Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of AHR protein]; Eugenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
Eugenol results in increased activity of AHR protein
Eugenol affects the localization of AHR protein

PMID:17275817 PMID:22686307 PMID:29191726

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aryl-hydrocarbon receptor repressor

increases expression

ISO

Eugenol results in increased expression of AHRR mRNA

NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:30,810,866...30,952,866

G

alpha-2-HS-glycoprotein

decreases expression

EXP

Eugenol results in decreased expression of AHSG protein

NCBI chr11:91,625,975...91,632,583
Ensembl chr11:91,625,975...91,634,039

G

aldo-keto reductase family 1 member B1

increases expression
decreases expression

ISO
EXP

Eugenol results in increased expression of AKR1B1 mRNA
Eugenol results in decreased expression of AKR1B1 protein

PMID:20566472 PMID:39793947

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315

G

aldo-keto reductase family 1 member B10

increases expression

ISO

Eugenol results in increased expression of AKR1B10 mRNA

PMID:20566472 PMID:26198647 PMID:30806763

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847

G

aldo-keto reductase family 1, member C1

increases expression

ISO

Eugenol results in increased expression of AKR1C1 mRNA

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

aldo-keto reductase family 1, member C13

increases expression

EXP

Eugenol results in increased expression of AKR1C13 protein

NCBI chr17:70,874,110...70,907,518
Ensembl chr17:70,874,917...70,907,824

G

aldo-keto reductase family 1, member C2

increases expression

ISO

Eugenol results in increased expression of AKR1C2 mRNA

NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686

G

aldo-keto reductase family 1, member C3

increases expression

ISO

Eugenol results in increased expression of AKR1C3 mRNA

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438

G

aldo-keto reductase family 7, member A2

decreases expression

EXP

Eugenol results in decreased expression of AKR7A2 protein

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:156,835,551...156,844,109

G

albumin

multiple interactions

EXP

Eugenol inhibits the reaction [Streptozocin results in decreased expression of ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 3 family, member A2

increases expression

EXP

Eugenol results in increased expression of ALDH3A2 protein

NCBI chr10:46,427,789...46,448,449
Ensembl chr10:46,407,993...46,448,648

G

alkaline phosphatase, biomineralization associated

increases expression

ISO

Eugenol results in increased expression of ALPL mRNA

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

acidic nuclear phosphoprotein 32 family member E

decreases expression

EXP

Eugenol results in decreased expression of ANP32E protein

NCBI chr 2:186,161,520...186,177,984
Ensembl chr 2:186,161,532...186,177,986

G

alanyl aminopeptidase, membrane

increases expression

EXP

Eugenol results in increased expression of ANPEP protein

NCBI chr 1:143,176,645...143,219,447
Ensembl chr 1:143,176,645...143,195,101

G

apoptotic peptidase activating factor 1

multiple interactions

ISO

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein]

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

acylaminoacyl-peptide hydrolase

decreases expression

EXP

Eugenol results in decreased expression of APEH protein

NCBI chr 8:117,652,390...117,661,502
Ensembl chr 8:117,652,393...117,661,711

G

apolipoprotein A1

decreases expression

EXP

Eugenol results in decreased expression of APOA1 protein

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729

G

aquaporin 1

increases expression

EXP

Eugenol results in increased expression of AQP1 protein

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504

G

androgen receptor

multiple interactions

ISO

Eugenol binds to and results in decreased activity of AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

ARF GTPase 4

increases expression

EXP

Eugenol results in increased expression of ARF4 protein

NCBI chr16:1,903,238...1,920,012
Ensembl chr16:1,903,371...1,920,011

G

Rho GTPase activating protein 17

decreases expression

ISO

Eugenol results in decreased expression of ARHGAP17 mRNA

NCBI chr 1:187,238,675...187,328,093
Ensembl chr 1:187,238,380...187,327,936

G

ARF like GTPase 4C

increases expression

ISO

Eugenol results in increased expression of ARL4C mRNA

NCBI chr 9:96,748,075...96,751,510
Ensembl chr 9:96,745,069...96,752,772

G

asparaginase

increases expression

EXP

Eugenol results in increased expression of ASPG protein

NCBI chr 6:136,997,832...137,017,417
Ensembl chr 6:136,998,023...137,017,417

G

activating transcription factor 3

increases expression

ISO

Eugenol results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

ATPase Na+/K+ transporting subunit alpha 1

increases expression

EXP

Eugenol results in increased expression of ATP1A1 protein

NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

EXP

Eugenol results in increased expression of ATP1B1 protein

NCBI chr13:79,319,708...79,340,226
Ensembl chr13:79,319,706...79,340,549

G

ATP synthase F1 subunit beta

increases expression

EXP

Eugenol results in increased expression of ATP5F1B protein

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462

G

ATP synthase membrane subunit e

increases expression

EXP

Eugenol results in increased expression of ATP5ME protein

NCBI chr14:1,464,788...1,465,989
Ensembl chr14:1,464,800...1,465,988

G

ATP synthase membrane subunit f

increases expression

EXP

Eugenol results in increased expression of ATP5MF protein

NCBI chr12:14,535,435...14,542,007
Ensembl chr12:14,522,832...14,542,709

G

ATP synthase membrane subunit G

increases expression

EXP

Eugenol results in increased expression of ATP5MG protein

NCBI chr 8:54,122,457...54,130,407
Ensembl chr 8:54,122,457...54,132,831

G

ATP synthase membrane subunit K

increases expression

EXP

Eugenol results in increased expression of ATP5MK protein

NCBI chr 1:255,915,255...255,922,185
Ensembl chr 1:255,915,259...255,922,106
Ensembl chr10:255,915,259...255,922,106

G

ATP synthase peripheral stalk-membrane subunit b

increases expression

EXP

Eugenol results in increased expression of ATP5PB protein

NCBI chr 2:196,112,459...196,123,737
Ensembl chr 2:196,112,108...196,124,387

G

ATP synthase peripheral stalk subunit F6

decreases expression

EXP

Eugenol results in decreased expression of ATP5PF protein

NCBI chr11:37,368,045...37,375,721
Ensembl chr11:37,368,042...37,375,466

G

ATPase H+ transporting V0 subunit a1

increases expression

EXP

Eugenol results in increased expression of ATP6V0A1 protein

NCBI chr10:86,436,089...86,490,185
Ensembl chr10:86,436,141...86,490,181

G

ATPase H+ transporting V0 subunit D2

decreases expression

EXP

Eugenol results in decreased expression of ATP6V0D2 protein

NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:38,133,158...38,182,245

G

ATPase H+ transporting V1 subunit C2

increases expression

EXP

Eugenol results in increased expression of ATP6V1C2 protein

NCBI chr 6:45,809,269...45,872,914
Ensembl chr 6:45,809,271...45,848,747

G

beta-2 microglobulin

increases expression

ISO

Eugenol results in increased expression of B2M mRNA

NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:129,549,318...129,555,356

G

BCL2-associated agonist of cell death

multiple interactions

ISO

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAD mRNA]

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]
Eugenol results in increased expression of BAX mRNA

PMID:20434464 PMID:20537511

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

ISO

[Eugenol results in increased activity of sulforaphane] which results in decreased expression of BCL2; [sulforaphane results in increased activity of Eugenol] which results in decreased expression of BCL2
Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of BCL2 mRNA]; Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of BCL2 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]
Eugenol results in decreased expression of BCL2 mRNA

PMID:20434464 PMID:20537511 PMID:21382956 PMID:21939359

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions

ISO

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2L1 mRNA]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

BCL2-associated transcription factor 1

decreases expression

ISO

Eugenol results in decreased expression of BCLAF1 mRNA

NCBI chr 1:16,904,572...16,937,106
Ensembl chr 1:16,914,118...16,936,801

G

3-hydroxybutyrate dehydrogenase 1

increases expression

EXP

Eugenol results in increased expression of BDH1 protein

NCBI chr11:82,806,125...82,848,133
Ensembl chr11:82,807,503...82,842,636

G

brain-derived neurotrophic factor

increases expression

ISO

Eugenol results in increased expression of BDNF mRNA

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

BH3 interacting domain death agonist

multiple interactions

ISO

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BID mRNA]

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

biliverdin reductase A

increases expression

EXP

Eugenol results in increased expression of BLVRA protein

NCBI chr 3:134,793,397...134,819,367
Ensembl chr 3:134,794,203...134,819,785

G

bone morphogenetic protein 6

increases expression

ISO

Eugenol results in increased expression of BMP6 mRNA

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

ISO

Eugenol results in decreased expression of BUB1 mRNA

NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:135,472,582...135,504,921

G

carbonic anhydrase 3

decreases expression

EXP

Eugenol results in decreased expression of CA3 protein

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

calbindin 1

decreases expression

EXP

Eugenol results in decreased expression of CALB1 protein

NCBI chr 5:34,172,612...34,199,555
Ensembl chr 5:34,172,664...34,200,160

G

calcitonin receptor like receptor

increases expression

ISO

Eugenol results in increased expression of CALCRL mRNA

NCBI chr 3:89,835,071...89,932,616
Ensembl chr 3:89,835,077...89,887,350

G

calmodulin 1

decreases expression

EXP

Eugenol results in decreased expression of CALM1 protein

NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381

G

calnexin

increases expression

EXP

Eugenol results in increased expression of CANX protein

NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857

G

caspase 3

multiple interactions
increases expression
increases activity
increases cleavage

ISO
EXP

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]
Eugenol results in increased expression of CASP3 mRNA
Eugenol results in increased activity of CASP3 protein
Eugenol inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein]; Eugenol inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
Eugenol results in increased expression of CASP3 protein modified form
Eugenol results in increased cleavage of CASP3 protein

PMID:20434464 PMID:20537511 PMID:21656368 PMID:25455450 PMID:30518369 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases expression

ISO

Eugenol results in increased expression of CASP7 mRNA

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 9

multiple interactions
increases expression
increases activity

ISO

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein]
Eugenol results in increased expression of CASP9 mRNA
Eugenol results in increased activity of CASP9 protein

PMID:20434464 PMID:25455450 PMID:30518369

Ensembl chr 5:159,391,188...159,409,648

G

catalase

increases expression
decreases expression
decreases activity
multiple interactions

ISO
EXP

Eugenol results in increased expression of CAT mRNA
Eugenol results in decreased expression of CAT protein
Eugenol results in decreased activity of CAT protein
Eugenol inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; Eugenol inhibits the reaction [Chlorpyrifos results in decreased expression of CAT protein]; Eugenol inhibits the reaction [metanil yellow results in decreased activity of CAT protein]
CAT protein inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]

PMID:15576237 PMID:20566472 PMID:30738991 PMID:32096903 PMID:33245926 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 12

increases expression

ISO

Eugenol results in increased expression of CCL13 mRNA

NCBI chr10:67,567,876...67,569,426
Ensembl chr10:67,567,876...67,569,426

G

C-C motif chemokine ligand 19

increases expression

ISO

Eugenol results in increased expression of CCL19 mRNA

NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:61,759,220...61,772,022

G

C-C motif chemokine ligand 2

increases expression
increases secretion
decreases expression

ISO

Eugenol results in increased expression of CCL2 mRNA
Eugenol results in increased secretion of CCL2 protein
Eugenol results in decreased expression of CCL2 mRNA

PMID:15585374 PMID:17374397 PMID:17936526 PMID:22245253

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 20

increases expression

ISO

Eugenol results in increased expression of CCL20 mRNA

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 3

increases expression
increases secretion

ISO

Eugenol results in increased expression of CCL3 mRNA
Eugenol results in increased secretion of CCL3 protein

PMID:15585374 PMID:23624239

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 4

increases expression
increases secretion

ISO

Eugenol results in increased expression of CCL4 mRNA; Eugenol results in increased expression of CCL4 protein
Eugenol results in increased secretion of CCL4 protein

PMID:15585374 PMID:18353026 PMID:30806763

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

cyclin B1

multiple interactions

EXP

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCNB1 mRNA]

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

multiple interactions

EXP

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

C-C motif chemokine receptor 2

decreases expression

ISO

Eugenol results in decreased expression of CCR2 mRNA

NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059

G

C-C motif chemokine receptor 5

increases expression

ISO

Eugenol results in increased expression of CCR5 mRNA

PMID:17936526 PMID:20713136

NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:132,629,683...132,637,594

G

C-C motif chemokine receptor 7

increases expression

ISO

Eugenol results in increased expression of CCR7 mRNA

NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501

G

CD24 molecule

decreases expression

ISO

Eugenol results in decreased expression of CD24 protein

NCBI chr20:48,655,549...48,661,786
Ensembl chr20:48,655,805...48,661,785

G

CD274 molecule

increases expression

ISO

Eugenol results in increased expression of CD274 protein

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951

G

CD36 molecule

decreases expression

ISO

Eugenol results in decreased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142

G

CD44 molecule

decreases expression

ISO

Eugenol results in decreased expression of CD44 protein

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

CD86 molecule

multiple interactions
increases expression

ISO

[Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein]

PMID:12423654 PMID:20488241 PMID:21742781 PMID:23624239 PMID:30806763

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361

G

CDC42 binding protein kinase beta

decreases expression

EXP

Eugenol results in decreased expression of CDC42BPB protein

NCBI chr 6:136,154,905...136,241,259
Ensembl chr 6:136,154,905...136,237,570

G

cadherin-related family member 5

increases expression

EXP

Eugenol results in increased expression of CDHR5 protein

NCBI chr 1:205,802,686...205,811,184
Ensembl chr 1:205,802,686...205,811,093

G

cyclin-dependent kinase 6

decreases expression

ISO

Eugenol results in decreased expression of CDK6 protein

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO
EXP

Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1A protein]

PMID:19851710 PMID:20043298

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

Eugenol results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

carboxylesterase 1E

decreases expression

EXP

Eugenol results in decreased expression of CES1E protein

NCBI chr19:30,006,173...30,042,628
Ensembl chr19:30,006,153...30,042,626

G

CDGSH iron sulfur domain 2

increases expression

EXP

Eugenol results in increased expression of CISD2 protein

NCBI chr 2:226,502,517...226,527,325
Ensembl chr 2:226,502,517...226,540,080

G

cytokine inducible SH2-containing protein

decreases expression

ISO

Eugenol results in decreased expression of CISH mRNA

NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:116,850,773...116,855,986

G

creatine kinase, mitochondrial 1

increases expression

EXP

Eugenol results in increased expression of CKMT1 protein

NCBI chr 3:128,783,408...128,789,485
Ensembl chr 3:128,783,597...128,789,483

G

C-type lectin domain family 4, member A3

decreases expression

ISO

Eugenol results in decreased expression of CLEC4A protein

NCBI chr 4:157,885,899...157,896,728
Ensembl chr 4:157,885,895...157,896,727

G

cannabinoid receptor 2

multiple interactions
increases expression

ISO

[caryophyllene co-treated with humulene co-treated with Eugenol co-treated with harpagoside] results in increased expression of CNR2 mRNA
Eugenol results in increased expression of CNR2 mRNA

NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961

G

cytochrome c oxidase assembly factor 7

decreases expression

EXP

Eugenol results in decreased expression of COA7 protein

NCBI chr 5:128,298,084...128,308,935
Ensembl chr 5:128,298,093...128,309,664

G

collagen type VI alpha 1 chain

increases expression

EXP

Eugenol results in increased expression of COL6A1 protein

NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107

G

collagen type VI alpha 2 chain

increases expression

EXP

Eugenol results in increased expression of COL6A2 protein

NCBI chr20:12,021,182...12,048,932
Ensembl chr20:12,021,265...12,057,042

G

catechol-O-methyltransferase

decreases expression

EXP

Eugenol results in decreased expression of COMT protein

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

catechol-O-methyltransferase domain containing 1

increases expression

EXP

Eugenol results in increased expression of COMTD1 protein

NCBI chr15:2,509,121...2,512,232
Ensembl chr15:2,509,032...2,512,232

G

coactosin-like F-actin binding protein 1

decreases expression

EXP

Eugenol results in decreased expression of COTL1 protein

NCBI chr19:64,780,309...64,814,629
Ensembl chr19:64,780,322...64,814,840

G

cytochrome c oxidase subunit 4i1

increases expression

EXP

Eugenol results in increased expression of COX4I1 protein

NCBI chr19:65,630,383...65,636,623
Ensembl chr19:65,630,432...65,636,624

G

cytochrome c oxidase subunit 6C

increases expression

EXP

Eugenol results in increased expression of COX6C2 protein

NCBI chr 7:69,014,410...69,027,145
Ensembl chr 7:69,014,417...69,027,166

G

cytochrome c oxidase subunit 7A2

increases expression

EXP

Eugenol results in increased expression of COX7A2 protein

NCBI chr 8:89,597,051...89,611,032
Ensembl chr14:55,514,261...55,514,512
Ensembl chr 8:55,514,261...55,514,512

G

carnitine palmitoyltransferase 1A

increases expression

EXP

Eugenol results in increased expression of CPT1A protein

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

complement C3b/C4b receptor 1 like

increases expression

EXP

Eugenol results in increased expression of CR1L protein

NCBI chr13:109,138,132...109,189,068
Ensembl chr13:109,103,235...109,188,869

G

cAMP responsive element binding protein 1

affects expression

ISO

Eugenol affects the expression of CREB1 mRNA

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

cAMP responsive element modulator

increases expression

ISO

Eugenol results in increased expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

crystallin, alpha B

increases expression

EXP

Eugenol results in increased expression of CRYAB protein

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528

G

catenin beta 1

multiple interactions
decreases expression

ISO

Eugenol results in decreased expression of and affects the phosphorylation of and affects the localization of CTNNB1 protein
Eugenol results in decreased expression of CTNNB1 mRNA

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin H

decreases expression

EXP

Eugenol results in decreased expression of CTSH protein

NCBI chr 8:99,488,756...99,507,639
Ensembl chr 8:99,488,874...99,509,181

G

cathepsin L

increases expression

ISO

Eugenol results in increased expression of CTSL mRNA

NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113

G

cathepsin S

decreases expression

EXP

Eugenol results in decreased expression of CTSS protein

NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:185,775,296...185,803,440

G

C-X-C motif chemokine ligand 1

increases expression

ISO

Eugenol results in increased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 3

increases expression
multiple interactions

ISO

Eugenol results in increased expression of CXCL1 mRNA
Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]

PMID:12963494 PMID:20713136

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine receptor 4

increases expression

ISO

Eugenol results in increased expression of CXCR4 mRNA

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

cytochrome b5 reductase 3

increases expression

EXP

Eugenol results in increased expression of CYB5R3 protein

NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:116,186,729...116,204,306

G

cytochrome c-1

increases expression

EXP

Eugenol results in increased expression of CYC1 protein

NCBI chr 7:109,947,750...109,950,142
Ensembl chr 7:109,947,766...109,950,657

G

cytochrome c, somatic

multiple interactions
decreases expression

ISO
EXP

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS protein]
Eugenol results in decreased expression of CYCS protein

PMID:20434464 PMID:39793947

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytoplasmic FMR1 interacting protein 1

increases expression

EXP

Eugenol results in increased expression of CYFIP1 protein

NCBI chr 1:115,842,754...115,935,163
Ensembl chr 1:115,846,661...115,951,292

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
decreases expression
decreases activity

ISO

[CYP1A1 protein co-treated with Copper] results in increased activity of Eugenol; Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Eugenol inhibits the reaction [CYP1A1 protein results in increased metabolism of and results in increased activity of 9,10-Dimethyl-1,2-benzanthracene]; Eugenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Eugenol results in increased expression of CYP1A1 mRNA
Eugenol results in decreased expression of CYP1A1 mRNA
Eugenol results in decreased activity of CYP1A1 protein

PMID:15576237 PMID:17275817 PMID:20713136 PMID:22686307 PMID:29191726

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

ISO

[CYP1A2 protein co-treated with Copper] results in increased activity of Eugenol

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
decreases activity

ISO

Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; Eugenol inhibits the reaction [CYP1B1 protein results in increased metabolism of and results in increased activity of 9,10-Dimethyl-1,2-benzanthracene]
Eugenol results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression

ISO

Eugenol results in decreased expression of CYP27A1 mRNA

NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215

G

cytochrome P450, family 2, subfamily c, polypeptide 23

increases expression

EXP

Eugenol results in increased expression of CYP2C23 protein

NCBI chr 1:252,838,427...252,863,081
Ensembl chr 1:252,838,433...252,863,067

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
increases metabolic processing

ISO

[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol; [CYP2D6 protein results in increased metabolism of Eugenol] which results in increased abundance of 2-hydroxychavicol; [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; bathocuproine inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]; CAT protein inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]; methional inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
increases expression

EXP
ISO

Eugenol inhibits the reaction [Thioacetamide results in increased expression of CYP2E1 protein]
Eugenol results in increased expression of CYP2E1 protein
[CYP2E1 protein co-treated with Copper] results in increased activity of Eugenol

PMID:15576237 PMID:20036707 PMID:39793947

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 4, subfamily a, polypeptide 2

increases expression

EXP

Eugenol results in increased expression of CYP4A2 protein

NCBI chr 5:134,160,356...134,170,908
Ensembl chr 5:134,160,358...134,176,156

G

cytochrome P450, family 4, subfamily a, polypeptide 3

increases expression

EXP

Eugenol results in increased expression of CYP4A14 protein

NCBI chr 5:134,334,396...134,352,268
Ensembl chr 5:134,334,701...134,352,236

G

cytochrome P450, family 4, subfamily a, polypeptide 8

increases expression

EXP

Eugenol results in increased expression of CYP4A8 protein

NCBI chr 5:133,938,882...133,970,226
Ensembl chr 5:133,938,883...133,970,226

G

2,4-dienoyl-CoA reductase 1

decreases expression

EXP

Eugenol results in decreased expression of DECR1 protein

NCBI chr 5:34,208,195...34,236,074
Ensembl chr 5:34,208,195...34,236,033

G

dehydrogenase/reductase 1

increases expression

EXP

Eugenol results in increased expression of DHRS1 protein

NCBI chr15:33,206,449...33,213,776
Ensembl chr15:33,206,451...33,213,734

G

dehydrogenase/reductase (SDR family) member 7-like 1

increases expression

EXP

Eugenol results in increased expression of DHRS7L1 protein

NCBI chr 6:97,025,094...97,047,899
Ensembl chr 6:97,025,094...97,047,899

G

dyskerin pseudouridine synthase 1

decreases expression

ISO

Eugenol results in decreased expression of DKC1 mRNA

NCBI chr  X:157,751,651...157,757,796
Ensembl chr  Y:380,743...385,405
Ensembl chr  X:380,743...385,405

G

DLG associated protein 5

decreases expression

ISO

Eugenol results in decreased expression of DLGAP5 mRNA

NCBI chr15:23,113,678...23,144,281
Ensembl chr15:23,113,678...23,144,176

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

ISO

Eugenol results in increased expression of DNAJB4 mRNA

PMID:23999411 PMID:27965148

NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042

G

deoxyribonuclease 2, lysosomal

increases expression

ISO

Eugenol results in increased expression of DNASE2A mRNA

NCBI chr19:40,149,505...40,152,225
Ensembl chr19:40,149,505...40,152,225

G

dipeptidylpeptidase 4

increases expression

EXP

Eugenol results in increased expression of DPP4 protein

NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422

G

dopamine receptor D1

multiple interactions

EXP

[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Eugenol

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166

G

dual specificity phosphatase 1

increases expression

ISO

Eugenol results in increased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

E2F transcription factor 1

decreases expression

ISO

Eugenol results in decreased expression of E2F1 mRNA; Eugenol results in decreased expression of E2F1 protein

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

E2F transcription factor 2

decreases expression

ISO

Eugenol results in decreased expression of E2F2 mRNA; Eugenol results in decreased expression of E2F2 protein

NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:153,682,789...153,706,087

G

E2F transcription factor 3

decreases expression

ISO

Eugenol results in decreased expression of E2F3 mRNA; Eugenol results in decreased expression of E2F3 protein

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725

G

E2F transcription factor 4

decreases expression

ISO

Eugenol results in decreased expression of E2F4 mRNA

NCBI chr19:50,084,335...50,091,731
Ensembl chr19:50,084,335...50,091,834

G

E2F transcription factor 5

decreases expression

ISO

Eugenol results in decreased expression of E2F5 mRNA

NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:88,718,567...88,734,143

G

E2F transcription factor 6

increases expression

ISO

Eugenol results in increased expression of E2F6 mRNA

NCBI chr 6:45,320,993...45,337,437
Ensembl chr 6:45,320,996...45,337,428

G

epidermal growth factor receptor

decreases expression
increases expression

ISO

Eugenol results in decreased expression of EGFR protein
Eugenol results in increased expression of EGFR mRNA

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

multiple interactions

ISO

[[Eugenol results in increased activity of OR5D18 protein] which results in increased abundance of Cyclic AMP] which results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 2

decreases expression

ISO

Eugenol results in decreased expression of EGR2 mRNA

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

elongin C

increases expression

EXP

Eugenol results in increased expression of ELOC protein

NCBI chr 5:7,444,769...7,461,187
Ensembl chr20:25,752,857...25,753,279

G

embigin

decreases expression

ISO

Eugenol results in decreased expression of EMB mRNA

NCBI chr 2:50,803,468...50,858,001
Ensembl chr 2:50,801,973...50,862,920

G

elastin microfibril interfacer 1

decreases expression

EXP

Eugenol results in decreased expression of EMILIN1 protein

NCBI chr 6:31,175,919...31,183,657
Ensembl chr 6:31,175,919...31,183,657

G

epithelial cell adhesion molecule

decreases expression
increases expression

ISO
EXP

Eugenol results in decreased expression of EPCAM protein
Eugenol results in increased expression of EPCAM protein
Eugenol results in decreased expression of EPCAM mRNA; Eugenol results in decreased expression of EPCAM protein

PMID:31926151 PMID:39793947

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702

G

epoxide hydrolase 2

increases expression

EXP

Eugenol results in increased expression of EPHX2 protein

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160

G

endoplasmic reticulum metallopeptidase 1

increases expression

EXP

Eugenol results in increased expression of ERMP1 protein

NCBI chr 1:236,801,459...236,835,656
Ensembl chr 1:236,801,466...236,839,197

G

estrogen receptor 1

affects binding
multiple interactions

ISO

Eugenol binds to ESR1 protein
Eugenol inhibits the reaction [Estradiol binds to ESR1 protein]

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

affects binding
multiple interactions

ISO

Eugenol binds to ESR2 protein
Eugenol inhibits the reaction [Estradiol binds to ESR2 protein]

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

coagulation factor XIII A1 chain

decreases expression

ISO

Eugenol results in decreased expression of F13A1 mRNA

NCBI chr17:28,021,197...28,197,960
Ensembl chr17:28,020,845...28,197,948

G

fatty acid binding protein 3

decreases expression

EXP

Eugenol results in decreased expression of FABP3 protein

NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881

G

family with sequence similarity 120 member A

increases expression

EXP

Eugenol results in increased expression of FAM120A protein

NCBI chr17:15,890,151...15,981,337
Ensembl chr17:15,890,605...15,981,332

G

family with sequence similarity 234, member A

increases expression

EXP

Eugenol results in increased expression of FAM234A protein

NCBI chr10:15,736,741...15,768,043
Ensembl chr10:15,736,742...15,749,835

G

fatty acid synthase

decreases expression

ISO

Eugenol results in decreased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

f-box protein 9

decreases expression

ISO

Eugenol results in decreased expression of FBXO9 mRNA

NCBI chr 8:87,838,787...87,864,362
Ensembl chr 8:87,838,789...87,864,504

G

Fc gamma receptor 2B

increases expression

ISO

Eugenol results in increased expression of FCGR2B mRNA

NCBI chr13:85,725,897...85,740,517
Ensembl chr13:85,725,897...85,740,517

G

ferrochelatase

increases expression

ISO

Eugenol results in increased expression of FECH mRNA

NCBI chr18:60,215,325...60,248,525
Ensembl chr18:60,215,325...60,249,546

G

FERM domain containing kindlin 2

increases expression

EXP

Eugenol results in increased expression of FERMT2 protein

NCBI chr15:21,162,603...21,257,995
Ensembl chr15:21,162,605...21,258,115

G

FERRY endosomal RAB5 effector complex subunit 3

decreases expression

ISO

Eugenol results in decreased expression of FERRY3 mRNA

NCBI chr 4:161,458,942...161,494,213
Ensembl chr 4:161,458,931...161,493,075

G

Fms related receptor tyrosine kinase 1

multiple interactions

EXP

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of FLT1 mRNA]

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750

G

flavin containing dimethylaniline monoxygenase 1

increases expression

EXP

Eugenol results in increased expression of FMO1 protein

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

flavin containing dimethylaniline monoxygenase 3

increases expression

EXP

Eugenol results in increased expression of FMO3 protein

NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256

G

flavin containing dimethylaniline monoxygenase 4

increases expression

EXP

Eugenol results in increased expression of FMO4 protein

NCBI chr13:77,687,909...77,706,100
Ensembl chr13:77,687,909...77,706,100

G

folate hydrolase 1

increases expression

EXP

Eugenol results in increased expression of FOLH1 protein

NCBI chr 1:149,828,286...149,914,313
Ensembl chr 1:149,840,760...149,914,035

G

folate receptor alpha

increases expression

EXP

Eugenol results in increased expression of FOLR1 protein

NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:165,631,462...165,642,669

G

FOS like 2, AP-1 transcription factor subunit

increases expression

ISO

Eugenol results in increased expression of FOSL2 mRNA

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406

G

ferritin light chain 1

increases expression
decreases expression

ISO
EXP

Eugenol results in increased expression of FTL mRNA
Eugenol results in decreased expression of FTL1 protein

PMID:20566472 PMID:39793947

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

glucose-6-phosphatase catalytic subunit 1

increases expression

EXP

Eugenol results in increased expression of G6PC1 protein

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

glucose-6-phosphate dehydrogenase

increases expression

ISO

Eugenol results in increased expression of G6PD mRNA

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

EXP

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of GADD45A mRNA]

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

growth arrest and DNA-damage-inducible, beta

increases expression

ISO

Eugenol results in increased expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

glycine amidinotransferase

decreases expression

EXP

Eugenol results in decreased expression of GATM protein

NCBI chr 3:130,112,508...130,137,664
Ensembl chr 3:130,112,509...130,129,355

G

glutamate-cysteine ligase, catalytic subunit

increases expression

ISO

Eugenol results in increased expression of GCLC mRNA

PMID:20566472 PMID:26198647 PMID:30806763

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

increases expression

ISO
EXP

Eugenol results in increased expression of GCLM mRNA
Eugenol results in increased expression of GCLM protein

PMID:20566472 PMID:26198647 PMID:27965148 PMID:30806763 PMID:39793947

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

gamma-glutamyltransferase 1

increases expression

EXP

Eugenol results in increased expression of GGT1 protein

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

ganglioside GM2 activator

decreases expression

EXP

Eugenol results in decreased expression of GM2A protein

NCBI chr10:39,719,919...39,732,452
Ensembl chr10:39,719,938...39,732,451

G

G protein subunit gamma 12

increases expression

EXP

Eugenol results in increased expression of GNG12 protein

NCBI chr 4:97,340,830...97,464,422
Ensembl chr 4:97,340,472...97,464,476

G

glucosamine (N-acetyl)-6-sulfatase

decreases expression

EXP

Eugenol results in decreased expression of GNS protein

NCBI chr 7:58,774,625...58,808,650
Ensembl chr 7:58,774,625...58,808,650

G

glutamic-oxaloacetic transaminase 1

multiple interactions

EXP

Eugenol inhibits the reaction [metanil yellow results in increased activity of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glycerol-3-phosphate acyltransferase 3

increases expression

ISO

Eugenol results in increased expression of GPAT3 mRNA

NCBI chr14:9,018,762...9,072,552

G

glutamic--pyruvic transaminase

multiple interactions

EXP

Eugenol inhibits the reaction [metanil yellow results in increased activity of GPT protein]; Eugenol inhibits the reaction [Streptozocin results in increased expression of GPT protein]

PMID:30738991 PMID:38047382

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 3

increases expression

ISO

Eugenol results in increased expression of GPX3 mRNA

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405

G

glycogen synthase kinase 3 beta

increases expression

ISO

Eugenol results in increased expression of GSK3B mRNA

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione-disulfide reductase

increases expression
decreases expression

ISO
EXP

Eugenol results in increased expression of GSR mRNA
Eugenol results in decreased expression of GSR protein

PMID:20566472 PMID:39793947

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 1

decreases activity
increases expression

ISO
EXP

Eugenol analog results in decreased activity of GSTA1 protein
Eugenol results in increased expression of GSTA1 protein

PMID:8620581 PMID:39793947

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

glutathione S-transferase alpha 2

increases expression
decreases activity

EXP

Eugenol results in increased expression of GSTA2 protein
Eugenol analog results in decreased activity of GSTA2 protein

PMID:8406240 PMID:8620581

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092

G

glutathione S-transferase alpha 3

decreases activity

EXP

Eugenol analog results in decreased activity of GSTA3 protein

NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654

G

glutathione S-transferase mu 1

decreases activity

ISO
EXP

Eugenol analog results in decreased activity of GSTM1 protein

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase mu 2

decreases activity

EXP

Eugenol analog results in decreased activity of GSTM2 protein

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase pi 1

decreases activity

ISO
EXP

Eugenol analog results in decreased activity of GSTP1 protein

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

H1.0 linker histone

increases expression

EXP

Eugenol results in increased expression of H1F0 protein

NCBI chr 7:112,473,280...112,475,140
Ensembl chr 7:112,473,222...112,475,006

G

H2A clustered histone 18

increases expression

EXP

Eugenol results in increased expression of H2AC18 protein

NCBI chr 2:186,497,271...186,497,865

G

H2A.J histone

increases expression

EXP

Eugenol results in increased expression of H2AJ protein

NCBI chr 4:171,406,922...171,407,406
Ensembl chr 4:171,406,177...171,408,845

G

HEAT repeat containing 5B

decreases expression

ISO

Eugenol results in decreased expression of HEATR5B mRNA

NCBI chr 6:21,995,558...22,075,582
Ensembl chr 6:21,995,602...22,075,582

G

hypoxia inducible factor 1 subunit alpha

increases expression

ISO

Eugenol results in increased expression of HIF1A mRNA

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

ISO

Eugenol results in decreased expression of HMGCR mRNA

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

heme oxygenase 1

increases expression

ISO

Eugenol results in increased expression of HMOX1 mRNA

PMID:20566472 PMID:20713136 PMID:23445166 PMID:26244607 PMID:30806763 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

histamine N-methyltransferase

increases expression

EXP

Eugenol results in increased expression of HNMT protein

NCBI chr 3:26,978,274...27,010,291
Ensembl chr 3:26,977,933...27,010,482

G

heterogeneous nuclear ribonucleoprotein A3

decreases expression

ISO

Eugenol results in decreased expression of HNRNPA3 mRNA

NCBI chr 3:80,984,470...80,999,413
Ensembl chr 3:80,985,969...80,996,043

G

heterogeneous nuclear ribonucleoprotein H2

increases expression

EXP

Eugenol results in increased expression of HNRNPH2 protein

NCBI chr X:102,074,175...102,080,115
Ensembl chr X:102,074,179...102,081,025

G

haptoglobin

decreases expression

EXP

Eugenol results in decreased expression of HP protein

NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518

G

HRas proto-oncogene, GTPase

decreases expression

ISO

Eugenol results in decreased expression of HRAS protein

NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590

G

hydroxysteroid 11-beta dehydrogenase 2

increases expression

EXP

Eugenol results in increased expression of HSD11B2 protein

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

hydroxysteroid (17-beta) dehydrogenase 11

increases expression

EXP

Eugenol results in increased expression of HSD17B11 protein

NCBI chr14:5,997,893...6,047,816
Ensembl chr14:5,997,906...6,047,811

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

ISO

Eugenol results in increased expression of HSPA6 mRNA

NCBI chr13:85,805,911...85,807,052

G

heat shock protein family H (Hsp110) member 1

increases expression

ISO

Eugenol results in increased expression of HSPH1 mRNA

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891

G

integrin-binding sialoprotein

decreases expression

ISO

Eugenol results in decreased expression of IBSP mRNA; Eugenol results in decreased expression of IBSP protein

NCBI chr14:5,744,497...5,757,242
Ensembl chr14:5,744,501...5,775,299

G

intercellular adhesion molecule 1

increases expression

ISO

Eugenol results in increased expression of ICAM1 mRNA; Eugenol results in increased expression of ICAM1 protein

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

ISO

Eugenol results in decreased expression of IDI1 mRNA

NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524

G

interferon gamma

increases secretion
multiple interactions

ISO

Eugenol results in increased secretion of IFNG protein
[Methoxychlor co-treated with Eugenol] results in increased expression of IFNG protein; [Parathion co-treated with Eugenol] results in increased expression of IFNG protein

PMID:20920556 PMID:22245253

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

immunoglobulin heavy chain 6

increases expression

EXP

Eugenol results in increased expression of IGH-6 protein

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

EXP

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of IKBKB protein]

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 10

multiple interactions

ISO

[Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Eugenol inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 12A

multiple interactions

ISO

Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]

NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997

G

interleukin 12B

multiple interactions

ISO

Eugenol inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 16

multiple interactions
increases secretion

ISO

Eugenol results in increased expression of and results in increased secretion of IL16 protein
Eugenol results in increased secretion of IL16 protein

PMID:23624239 PMID:30806763

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023

G

interleukin 18

increases expression

ISO

Eugenol results in increased expression of IL18 protein

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 alpha

increases expression

ISO

Eugenol results in increased expression of IL1A mRNA

PMID:30806763 PMID:33715048

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions
increases expression
decreases expression

ISO

[Eugenol results in increased activity of sulforaphane] which results in decreased expression of IL1B; [sulforaphane results in increased activity of Eugenol] which results in decreased expression of IL1B; Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL1B protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Eugenol results in increased expression of IL1B mRNA
Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Eugenol results in decreased expression of IL1B mRNA

PMID:12963494 PMID:17509409 PMID:20713136 PMID:21382956 PMID:21807015 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 2

increases expression

ISO

Eugenol results in increased expression of IL1R2 mRNA

PMID:20713136 PMID:30806763

NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:49,877,266...49,920,374

G

interleukin 2

increases expression
increases secretion

ISO

Eugenol results in increased expression of IL2 protein
Eugenol results in increased secretion of IL2 protein

PMID:22245253 PMID:22381623

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 4 receptor

increases expression

ISO

Eugenol results in increased expression of IL4RA protein

NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636

G

interleukin 6

multiple interactions
increases secretion
increases expression

ISO
EXP

Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased secretion of IL6 protein]
Eugenol results in increased secretion of IL6 protein
Eugenol inhibits the reaction [Thioacetamide results in increased activity of IL6 protein]
Eugenol results in increased expression of IL6 mRNA

PMID:20036707 PMID:20043298 PMID:21870829 PMID:22245253

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 7 receptor

increases expression

ISO

Eugenol results in increased expression of IL7R mRNA

NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:60,181,382...60,211,027

G

inhibin subunit beta A

decreases expression

ISO

Eugenol results in decreased expression of INHBA mRNA

NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508

G

indolethylamine N-methyltransferase

increases expression

EXP

Eugenol results in increased expression of INMT protein

NCBI chr 4:85,648,459...85,652,755
Ensembl chr 4:85,648,459...85,652,755

G

interaction protein for cytohesin exchange factors 1

decreases expression

ISO

Eugenol results in decreased expression of IPCEF1 mRNA

NCBI chr 1:45,654,252...45,857,045
Ensembl chr 1:45,662,818...45,856,993

G

integrin subunit alpha 3

increases expression

EXP

Eugenol results in increased expression of ITGA3 protein

NCBI chr10:80,486,998...80,522,548
Ensembl chr10:80,486,999...80,518,901

G

integrin subunit alpha 6

increases expression

ISO

Eugenol results in increased expression of ITGA6 mRNA

NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076

G

integrin subunit beta 1

increases expression

ISO
EXP

Eugenol results in increased expression of ITGB1 mRNA
Eugenol results in increased expression of ITGB1 protein

PMID:17936526 PMID:39793947

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

inosine triphosphatase

decreases expression

EXP

Eugenol results in decreased expression of ITPA protein

NCBI chr 3:138,338,549...138,350,329
Ensembl chr 3:138,338,349...138,350,329

G

inositol 1,4,5-trisphosphate receptor, type 1

increases expression

EXP

Eugenol results in increased expression of ITPR1 protein

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504

G

potassium voltage-gated channel subfamily A member 5

decreases activity

ISO

Eugenol results in decreased activity of KCNA5 protein

NCBI chr 4:161,040,853...161,044,311
Ensembl chr 4:160,996,950...161,044,408

G

potassium inwardly-rectifying channel, subfamily J, member 2

decreases expression

ISO

Eugenol results in decreased expression of KCNJ2 mRNA

NCBI chr10:96,560,225...96,570,788
Ensembl chr10:96,565,600...96,570,901

G

kinesin family member 23

decreases expression

ISO

Eugenol results in decreased expression of KIF23 mRNA

NCBI chr 8:71,293,439...71,321,911
Ensembl chr 8:71,293,482...71,320,856

G

kynurenine 3-monooxygenase

increases expression

EXP

Eugenol results in increased expression of KMO protein

NCBI chr13:90,089,340...90,121,108
Ensembl chr13:90,089,463...90,125,151

G

keratin 19

increases expression

EXP

Eugenol results in increased expression of KRT19 protein

NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,576,235...85,580,952

G

leucine zipper and EF-hand containing transmembrane protein 1

increases expression

EXP

Eugenol results in increased expression of LETM1 protein

NCBI chr14:81,167,268...81,206,776
Ensembl chr14:81,162,309...81,209,459

G

legumain

decreases expression

EXP

Eugenol results in decreased expression of LGMN protein

NCBI chr 6:127,308,913...127,347,355
Ensembl chr 6:127,308,913...127,347,328

G

lectin, mannose-binding 2

increases expression

EXP

Eugenol results in increased expression of LMAN2 protein

NCBI chr17:9,274,362...9,294,950
Ensembl chr17:9,274,136...9,292,370

G

LIM domain containing preferred translocation partner in lipoma

increases expression

EXP

Eugenol results in increased expression of LPP protein

NCBI chr11:89,292,060...89,933,973
Ensembl chr11:89,305,187...89,805,264

G

MAF bZIP transcription factor F

increases expression

ISO

Eugenol results in increased expression of MAFF mRNA

NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147

G

MAF bZIP transcription factor G

increases expression

ISO

Eugenol results in increased expression of MAFG mRNA

NCBI chr10:106,401,633...106,410,159

G

MAF bZIP transcription factor K

increases expression

ISO

Eugenol results in increased expression of MAFK mRNA

NCBI chr12:19,948,473...19,970,351
Ensembl chr12:19,948,476...19,959,192

G

mal, T-cell differentiation protein 2

increases expression

EXP

Eugenol results in increased expression of MAL2 protein

NCBI chr 7:87,790,239...87,823,219
Ensembl chr 7:87,790,239...87,850,403

G

monoamine oxidase A

increases expression

EXP

Eugenol results in increased expression of MAOA protein

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

MCTS1, re-initiation and release factor

decreases expression

ISO

Eugenol results in decreased expression of MCTS1 mRNA

NCBI chr X:122,215,602...122,228,101
Ensembl chr X:122,216,439...122,229,631

G

malic enzyme 1

increases expression
decreases expression

ISO
EXP

Eugenol results in increased expression of ME1 mRNA
Eugenol results in decreased expression of ME1 protein

PMID:20566472 PMID:39793947

NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275

G

meprin A subunit alpha

increases expression

EXP

Eugenol results in increased expression of MEP1A protein

NCBI chr 9:24,971,901...25,001,414
Ensembl chr 9:24,971,886...25,001,414

G

meprin A subunit beta

increases expression

EXP

Eugenol results in increased expression of MEP1B protein

NCBI chr18:12,641,041...12,667,759
Ensembl chr18:12,641,041...12,667,755

G

microsomal glutathione S-transferase 1

increases expression

ISO

Eugenol results in increased expression of MGST1 mRNA

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

Mir100 Mirlet7a-2 Mir125b-1 cluster host gene like

decreases expression

EXP

Eugenol results in decreased expression of MIR100HGL protein

NCBI chr 8:50,595,904...50,860,909

G

microRNA 146a

increases expression

ISO

Eugenol results in increased expression of MIR146A mRNA

NCBI chr10:28,349,996...28,350,090

G

membrane metallo-endopeptidase

increases expression

EXP

Eugenol results in increased expression of MME protein

NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463

G

matrix metallopeptidase 13

multiple interactions

ISO

[caryophyllene co-treated with humulene co-treated with Eugenol co-treated with harpagoside] results in decreased expression of MMP13 mRNA

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 2

multiple interactions
decreases expression

EXP
ISO

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP2 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP2 mRNA]
Eugenol results in decreased expression of MMP2 mRNA

PMID:20434464 PMID:30518369

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

multiple interactions
decreases expression

EXP
ISO

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP9 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP9 mRNA]
Eugenol results in decreased expression of MMP9 mRNA

PMID:20434464 PMID:30518369

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

mannosyl-oligosaccharide glucosidase

increases expression

EXP

Eugenol results in increased expression of MOGS protein

NCBI chr 4:117,179,335...117,182,738
Ensembl chr 4:117,179,335...117,182,744

G

mitochondrial pyruvate carrier 2

increases expression

EXP

Eugenol results in increased expression of MPC2 protein

NCBI chr13:80,261,143...80,280,668
Ensembl chr13:80,259,727...80,280,668

G

myeloperoxidase

multiple interactions

EXP

Eugenol inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Eugenol inhibits the reaction [Thioacetamide results in increased activity of MPO protein]

PMID:20036707 PMID:33245926

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mitochondrial ribosomal protein L35

decreases expression

ISO

Eugenol results in decreased expression of MRPL35 mRNA

NCBI chr 4:105,424,076...105,431,844
Ensembl chr 4:105,407,993...105,438,793

G

membrane spanning 4-domains A7

increases expression

ISO

Eugenol results in increased expression of MS4A7 mRNA

NCBI chr 1:217,394,019...217,409,643
Ensembl chr 1:217,394,019...217,409,643

G

mitochondrially encoded cytochrome c oxidase II

increases expression

EXP

Eugenol results in increased expression of COX2 protein

NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2

increases expression

EXP

Eugenol results in increased expression of ND2 protein

NCBI chr MT:3,904...4,942
Ensembl chr MT:3,892...4,929

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4

increases expression

EXP

Eugenol results in increased expression of ND4 protein

NCBI chr MT:10,160...11,537
Ensembl chr MT:10,145...11,522

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5

increases expression

EXP

Eugenol results in increased expression of ND5 protein

NCBI chr MT:11,736...13,565
Ensembl chr MT:11,721...13,553

G

metallothionein 3

increases expression

ISO

Eugenol results in increased expression of MT3 mRNA

NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080

G

mitochondrial amidoxime reducing component 2

increases expression

EXP

Eugenol results in increased expression of MTARC2 protein

NCBI chr13:98,894,347...98,928,754
Ensembl chr13:98,897,108...98,928,781

G

mechanistic target of rapamycin kinase

increases activity

EXP

Eugenol results in increased activity of MTOR protein

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

major urinary protein 4 like 1

decreases expression

EXP

Eugenol results in decreased expression of MUP4L1 protein

NCBI chr 5:80,223,093...80,226,566

G

max dimerization protein 1

increases expression

ISO

Eugenol results in increased expression of MXD1 mRNA

NCBI chr 4:120,654,731...120,678,972
Ensembl chr 4:120,654,731...120,675,129

G

MYB proto-oncogene, transcription factor

decreases expression

ISO

Eugenol results in decreased expression of MYB mRNA

NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

ISO

Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MYC protein]

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

myosin 1C

increases expression

EXP

Eugenol results in increased expression of MYO1C protein

NCBI chr10:60,996,642...61,019,022
Ensembl chr10:60,996,638...61,019,022

G

myosin IE

increases expression

EXP

Eugenol results in increased expression of MYO1E protein

NCBI chr 8:79,768,828...79,961,048
Ensembl chr 8:79,753,596...79,961,045

G

nicotinamide phosphoribosyltransferase

increases expression

ISO

Eugenol results in increased expression of NAMPT mRNA

NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544

G

N-acetyltransferase 8 (GCN5-related) family member 1

increases expression

EXP

Eugenol results in increased expression of NAT8F1 protein

NCBI chr 4:119,893,672...119,900,357
Ensembl chr 4:119,886,460...119,916,005

G

nicalin

increases expression

EXP

Eugenol results in increased expression of NCLN protein

NCBI chr 7:8,862,324...8,872,699
Ensembl chr 7:8,862,751...8,872,698

G

NADH:ubiquinone oxidoreductase subunit A11

increases expression

EXP

Eugenol results in increased expression of NDUFA11 protein

NCBI chr 9:1,637,614...1,641,673
Ensembl chr 9:1,637,595...1,642,727

G

NADH:ubiquinone oxidoreductase subunit AB1

decreases expression

EXP

Eugenol results in decreased expression of NDUFAB1 protein

NCBI chr 1:186,075,933...186,091,843
Ensembl chr 1:186,057,113...186,089,373

G

NADH:ubiquinone oxidoreductase subunit B11

increases expression

EXP

Eugenol results in increased expression of NDUFB11 protein

NCBI chr X:4,126,317...4,128,575
Ensembl chr X:4,126,245...4,128,566

G

NADH:ubiquinone oxidoreductase subunit B6

increases expression

EXP

Eugenol results in increased expression of NDUFB6 protein

NCBI chr 5:60,196,585...60,206,152
Ensembl chr 5:60,196,585...60,206,055

G

NADH:ubiquinone oxidoreductase subunit B8

increases expression

EXP

Eugenol results in increased expression of NDUFB8 protein

NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:253,357,841...253,362,936

G

NADH:ubiquinone oxidoreductase subunit C2

increases expression

EXP

Eugenol results in increased expression of NDUFC2 protein

NCBI chr 1:161,122,370...161,129,413
Ensembl chr 1:161,123,150...161,129,419

G

NFE2 like bZIP transcription factor 2

affects expression
decreases expression
multiple interactions

ISO

Eugenol affects the expression of NFE2L2 protein
Eugenol results in decreased expression of NFE2L2 mRNA
Eugenol promotes the reaction [NFE2L2 protein results in increased expression of NQO1 mRNA]

PMID:17275817 PMID:31967339

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions
affects expression

ISO
EXP

Eugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
Eugenol affects the expression of NFKB1 mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]

PMID:10871845 PMID:19851710 PMID:20385217

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions

EXP
ISO

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKBIA protein modified form]
Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NFKBIA protein modified form]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

PMID:12963494 PMID:19851710 PMID:20043298

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFS1 cysteine desulfurase

increases expression

EXP

Eugenol results in increased expression of NFS1 protein

NCBI chr 3:165,097,390...165,119,730
Ensembl chr 3:165,097,391...165,119,737

G

NME/NM23 nucleoside diphosphate kinase 2

increases expression

EXP

Eugenol results in increased expression of NME2 protein

NCBI chr10:79,394,999...79,400,418
Ensembl chr20:11,179,066...11,179,497
Ensembl chr10:11,179,066...11,179,497

G

nicotinamide nucleotide transhydrogenase

increases expression

EXP

Eugenol results in increased expression of NNT protein

NCBI chr 2:53,144,157...53,237,857
Ensembl chr 2:53,144,160...53,237,310

G

non-POU domain containing, octamer-binding

increases expression

EXP

Eugenol results in increased expression of NONO protein

NCBI chr X:70,594,116...70,611,976
Ensembl chr X:70,593,888...70,611,979

G

nitric oxide synthase 2

multiple interactions

ISO

Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NOS2 protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Eugenol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]

PMID:20043298 PMID:21237301

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

notch receptor 1

decreases expression

ISO

Eugenol results in decreased expression of NOTCH1 protein
Eugenol results in decreased expression of NOTCH1 mRNA; Eugenol results in decreased expression of NOTCH1 protein

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613

G

N-acetylneuraminate pyruvate lyase

decreases expression

EXP

Eugenol results in decreased expression of NPL protein

NCBI chr13:68,205,602...68,247,940
Ensembl chr13:68,205,603...68,247,999

G

NAD(P)H quinone dehydrogenase 1

increases expression
increases activity
multiple interactions

ISO

Eugenol results in increased expression of NQO1 mRNA; Eugenol results in increased expression of NQO1 protein
Eugenol results in increased activity of NQO1 protein
[Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein]; Eugenol promotes the reaction [NFE2L2 protein results in increased expression of NQO1 mRNA]

PMID:17275817 PMID:20566472 PMID:21742781

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 2

increases expression

ISO

Eugenol results in increased expression of NR1I2 mRNA

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

increases expression

EXP

Eugenol results in increased expression of NSF protein

NCBI chr10:89,227,937...89,357,383
Ensembl chr10:89,227,937...89,367,621

G

nucleoporin 88

increases expression

ISO

Eugenol results in increased expression of NUP88 mRNA

NCBI chr10:56,166,486...56,190,829
Ensembl chr10:56,166,486...56,191,383

G

alpha-2u globulin PGCL4

decreases expression

EXP

Eugenol results in decreased expression of OBP3 protein

NCBI chr 5:79,637,234...79,640,810
Ensembl chr 5:79,637,234...79,640,675

G

olfactory receptor family 5 subfamily D member 18

multiple interactions
increases activity
affects binding

ISO

[[Eugenol results in increased activity of OR5D18 protein] which results in increased abundance of Cyclic AMP] which results in increased expression of EGR1 mRNA; [Eugenol binds to and results in increased activity of OR5D18 protein] which results in increased abundance of Cyclic AMP; [Eugenol binds to and results in increased activity of OR5D18 protein] which results in increased transport of Calcium; [Eugenol binds to OR5D18 protein] which results in increased transport of Calcium; [Eugenol results in increased activity of OR5D18 protein] which results in increased abundance of Cyclic AMP; Eugenol binds to and results in increased activity of OR5D18 protein; isomethyleugenol inhibits the reaction [[Eugenol binds to OR5D18 protein] which results in increased transport of Calcium]

PMID:12767924 PMID:14685265 PMID:15716417 PMID:19723634

NCBI chr 3:93,972,754...93,973,695
Ensembl chr 3:93,972,754...93,973,695

G

oxysterol binding protein-like 8

increases expression

EXP

Eugenol results in increased expression of OSBPL8 protein

NCBI chr 7:48,483,259...48,636,151
Ensembl chr 7:48,483,022...48,636,151

G

purinergic receptor P2X 3

multiple interactions

EXP

Eugenol inhibits the reaction [P2RX3 protein affects the activity of Adenosine Triphosphate]

NCBI chr 3:90,487,506...90,531,315
Ensembl chr 3:90,487,506...90,531,794

G

phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

decreases expression

ISO

Eugenol results in decreased expression of PAICS mRNA

NCBI chr14:31,553,355...31,586,843
Ensembl chr14:31,553,357...31,587,027

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

Eugenol affects the reaction [Methylnitronitrosoguanidine affects the cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

proliferating cell nuclear antigen

multiple interactions

ISO
EXP

Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCNA protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA protein]

PMID:19851710 PMID:20043298

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

phosphodiesterase 4B

increases expression

ISO

Eugenol results in increased expression of PDE4B mRNA

NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267

G

pyruvate dehydrogenase E1 subunit beta

increases expression

EXP

Eugenol results in increased expression of PDHB protein

NCBI chr15:19,182,789...19,188,731
Ensembl chr15:19,181,208...19,188,976

G

penta-EF hand domain containing 1

decreases expression

EXP

Eugenol results in decreased expression of PEF1 protein

NCBI chr 5:147,735,973...147,759,239
Ensembl chr 5:147,735,976...147,761,092

G

phosphogluconate dehydrogenase

increases expression

ISO

Eugenol results in increased expression of PGD mRNA

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

phosphatidylinositol binding clathrin assembly protein

increases expression

ISO

Eugenol results in increased expression of PICALM mRNA

NCBI chr 1:153,468,982...153,550,086
Ensembl chr 1:153,469,202...153,550,237

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

EXP
ISO

Eugenol results in increased expression of PIK3R1 mRNA

PMID:20724125 PMID:21870829

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

plasminogen activator, tissue type

increases expression

ISO

Eugenol results in increased expression of PLAT mRNA

NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696

G

phospholipase C beta 1

decreases expression

EXP

Eugenol results in decreased expression of PLCB1 protein

NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646

G

plasmalemma vesicle associated protein

increases expression

EXP

Eugenol results in increased expression of PLVAP protein

NCBI chr16:18,218,966...18,231,279
Ensembl chr16:18,218,967...18,231,454

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

ISO

Eugenol results in increased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

POU class 5 homeobox 1

decreases expression

ISO

Eugenol results in decreased expression of POU5F1 protein
Eugenol results in decreased expression of POU5F1 mRNA; Eugenol results in decreased expression of POU5F1 protein

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

ISO

Eugenol analog binds to and results in increased activity of PPARG protein
Eugenol results in increased expression of PPARG mRNA
bisphenol A diglycidyl ether inhibits the reaction [Eugenol analog binds to and results in increased activity of PPARG protein]; Eugenol analog binds to and results in increased activity of PPARG protein

PMID:20064974 PMID:21870829

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

pro-platelet basic protein

multiple interactions
increases expression

ISO

Eugenol results in increased expression of and results in increased secretion of PPBP protein
Eugenol results in increased expression of PPBP mRNA

NCBI chr14:17,586,495...17,587,299
Ensembl chr14:17,586,495...17,587,299

G

peptidylprolyl isomerase C

increases expression

EXP

Eugenol results in increased expression of PPIC protein

NCBI chr18:49,040,690...49,053,296
Ensembl chr18:49,040,692...49,053,466

G

peptidylprolyl isomerase F

increases expression

EXP

Eugenol results in increased expression of PPIF protein

NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,263,541...1,316,954

G

peroxiredoxin 3

decreases expression

ISO

Eugenol results in decreased expression of PRDX3 mRNA

NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300

G

proline and arginine rich end leucine rich repeat protein

increases expression

EXP

Eugenol results in increased expression of PRELP protein

NCBI chr13:47,920,480...47,943,547
Ensembl chr13:47,922,590...47,932,324

G

peroxiredoxin like 2A

increases expression

EXP

Eugenol results in increased expression of PRXL2A protein

NCBI chr16:16,900,697...16,920,521
Ensembl chr16:16,900,699...16,920,561

G

prosaposin

decreases expression

EXP

Eugenol results in decreased expression of PSAP protein

NCBI chr20:28,756,951...28,783,422
Ensembl chr20:28,757,181...28,783,421

G

proteasome 20S subunit alpha 3

decreases expression

EXP

Eugenol results in decreased expression of PSMA3 protein

NCBI chr 6:95,219,714...95,239,745
Ensembl chr 6:95,219,629...95,241,032

G

prostaglandin E receptor 3

decreases expression

ISO

Eugenol results in decreased expression of PTGER3 mRNA

NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:249,264,985...249,409,846

G

prostaglandin reductase 1

increases expression

ISO

Eugenol results in increased expression of PTGR1 mRNA

NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression
decreases expression

ISO
EXP

Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 mRNA]; Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
Eugenol results in increased expression of PTGS2 mRNA
Eugenol results in decreased expression of PTGS2 mRNA
Eugenol inhibits the reaction [Thioacetamide results in increased expression of PTGS2 protein]; Eugenol inhibits the reaction [Thioacetamide results in increased expression of PTGS2]
Eugenol inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased abundance of Dinoprostone]; Eugenol inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased metabolism of Arachidonic Acid]; Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Eugenol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]

PMID:12757841 PMID:16101137 PMID:17509409 PMID:20036707 PMID:20043298 More...

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RAB18, member RAS oncogene family

decreases expression

EXP

Eugenol results in decreased expression of RAB18 protein

NCBI chr17:59,639,264...59,670,653
Ensembl chr17:59,639,203...59,672,806

G

Rac family small GTPase 1

increases expression

EXP

Eugenol results in increased expression of RAC1 protein

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

RAS like proto-oncogene A

increases expression

EXP

Eugenol results in increased expression of RALA protein

NCBI chr17:51,787,682...51,840,738
Ensembl chr17:51,787,699...51,840,733

G

RB transcriptional corepressor 1

decreases expression

ISO

Eugenol results in decreased expression of RB1 protein

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

reversion-inducing-cysteine-rich protein with kazal motifs

multiple interactions

EXP

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK protein]

NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:62,898,668...62,965,270

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO
EXP

Eugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of RELA protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA protein]

PMID:10871845 PMID:19851710 PMID:20043298

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

retention in endoplasmic reticulum sorting receptor 1

increases expression

EXP

Eugenol results in increased expression of RER1 protein

NCBI chr 5:170,916,643...170,929,073
Ensembl chr 5:170,916,905...170,928,980

G

retinol saturase

increases expression

EXP

Eugenol results in increased expression of RETSAT protein

NCBI chr 4:106,211,459...106,220,222
Ensembl chr 4:106,211,436...106,229,552

G

regucalcin

increases expression

EXP

Eugenol results in increased expression of RGN protein

NCBI chr X:4,172,537...4,190,112
Ensembl chr X:4,172,537...4,190,251

G

regulator of G-protein signaling 1

increases expression

ISO

Eugenol results in increased expression of RGS1 mRNA

PMID:17374397 PMID:20713136

NCBI chr13:58,568,844...58,573,187
Ensembl chr13:58,568,844...58,573,187

G

reactive intermediate imine deaminase A homolog

decreases expression

EXP

Eugenol results in decreased expression of RIDA protein

NCBI chr 7:67,576,586...67,590,493
Ensembl chr 7:67,576,586...67,590,692

G

ribosomal protein L10

increases expression

EXP

Eugenol results in increased expression of RPL10 protein

NCBI chr X:157,205,850...157,208,057
Ensembl chr X:157,205,836...157,208,049

G

ribosomal protein L21

increases expression

EXP

Eugenol results in increased expression of RPL21 protein

NCBI chr12:13,382,516...13,386,153
Ensembl chr12:13,382,516...13,386,153
Ensembl chr13:13,382,516...13,386,153

G

ribosomal protein L22

increases expression

EXP

Eugenol results in increased expression of RPL22 protein

NCBI chr 5:168,114,432...168,126,114
Ensembl chr 5:168,111,074...168,126,114
Ensembl chr 4:168,111,074...168,126,114
Ensembl chr 7:168,111,074...168,126,114

G

ribosomal protein L27A

increases expression

ISO
EXP

Eugenol results in increased expression of RPL27A mRNA
Eugenol results in increased expression of RPL27A protein

PMID:17374397 PMID:39793947

NCBI chr 1:172,971,957...172,977,591

G

ribosomal protein L36

increases expression

EXP

Eugenol results in increased expression of RPL36 protein

NCBI chr 9:1,529,117...1,534,534
Ensembl chr 1:126,560,003...126,560,369

G

ribosomal protein L4

increases expression

EXP

Eugenol results in increased expression of RPL4 protein

NCBI chr 8:73,566,477...73,571,600
Ensembl chr 8:73,566,466...73,571,788

G

ribosomal protein L6

increases expression

EXP

Eugenol results in increased expression of RPL6 protein

NCBI chr12:41,008,142...41,012,756
Ensembl chr12:41,008,142...41,025,733

G

ribosomal protein L7

increases expression

EXP

Eugenol results in increased expression of RPL7 protein

NCBI chr 5:8,000,446...8,003,454
Ensembl chr 5:7,850,630...8,003,451

G

ribophorin II

increases expression

EXP

Eugenol results in increased expression of RPN2 protein

NCBI chr 3:166,361,955...166,409,272
Ensembl chr 3:166,362,049...166,409,922

G

ribosomal protein S13

increases expression

EXP

Eugenol results in increased expression of RPS13 protein

NCBI chr 1:180,007,230...180,009,660
Ensembl chr 1:180,002,471...180,009,660

G

ribosomal protein S17

increases expression

EXP

Eugenol results in increased expression of RPS17 protein

NCBI chr 1:144,705,150...144,707,736
Ensembl chr 1:144,705,149...144,707,734
Ensembl chr 8:144,705,149...144,707,734

G

ribosomal protein S18

decreases expression

EXP

Eugenol results in decreased expression of RPS18 protein

NCBI chr20:4,933,741...4,937,423
Ensembl chr20:4,917,095...4,937,423

G

ribosomal protein s25

increases expression

EXP

Eugenol results in increased expression of RPS25 protein

NCBI chr 8:53,630,333...53,632,810
Ensembl chr 8:53,629,861...53,632,808
Ensembl chr 8:53,629,861...53,632,808

G

ribosomal protein S9

increases expression

EXP

Eugenol results in increased expression of RPS9 protein

NCBI chr 1:74,427,084...74,430,513
Ensembl chr 1:74,427,087...74,430,105

G

RAS related

increases expression

EXP

Eugenol results in increased expression of RRAS protein

NCBI chr 1:104,637,061...104,640,841
Ensembl chr 1:104,634,951...104,640,841

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

ISO

Eugenol results in increased expression of RRM2B mRNA

NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:70,965,590...70,993,670

G

S100 calcium binding protein A6

decreases expression

EXP

Eugenol results in decreased expression of S100A6 protein

NCBI chr 2:178,398,189...178,399,763
Ensembl chr 2:178,398,481...178,399,762

G

SAC1 like phosphatidylinositide phosphatase

increases expression

EXP

Eugenol results in increased expression of SACM1L protein

NCBI chr 8:132,053,465...132,109,857
Ensembl chr 8:132,053,049...132,109,857

G

SAMM50 sorting and assembly machinery component

increases expression

EXP

Eugenol results in increased expression of SAMM50 protein

NCBI chr 7:117,197,460...117,221,668
Ensembl chr 7:117,197,381...117,224,581

G

spermidine/spermine N1-acetyl transferase 1

increases expression

ISO

Eugenol results in increased expression of SAT1 mRNA

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:44,006,781...44,011,374

G

saccharopine dehydrogenase (putative)

increases expression

EXP

Eugenol results in increased expression of SCCPDH protein

NCBI chr13:93,932,086...93,953,840
Ensembl chr13:93,912,395...93,954,192

G

serine carboxypeptidase 1

decreases expression

EXP

Eugenol results in decreased expression of SCPEP1 protein

NCBI chr10:74,200,491...74,230,107
Ensembl chr10:74,200,491...74,230,241

G

syndecan 2

increases expression

ISO

Eugenol results in increased expression of SDC2 mRNA

NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:66,108,853...66,126,294

G

succinate dehydrogenase complex subunit C

increases expression

EXP

Eugenol results in increased expression of SDHC protein

NCBI chr13:86,077,133...86,098,025
Ensembl chr13:86,077,134...86,098,044

G

Sec23 homolog A, COPII coat complex component

increases expression

EXP

Eugenol results in increased expression of SEC23A protein

NCBI chr 6:82,393,699...82,442,594
Ensembl chr 6:82,394,863...82,440,904

G

septin 11

decreases expression

ISO

Eugenol results in decreased expression of SEPTIN11 mRNA

NCBI chr14:15,119,760...15,275,222
Ensembl chr14:15,128,951...15,275,200

G

serine (or cysteine) proteinase inhibitor, clade A, member 3C

decreases expression

EXP

Eugenol results in decreased expression of SERPINA3K protein

NCBI chr 6:129,007,578...129,014,988
Ensembl chr 6:128,829,577...129,014,971

G

serpin family B member 3

increases expression

ISO

Eugenol results in increased expression of SERPINB3 mRNA

NCBI chr13:23,788,758...23,795,298
Ensembl chr13:23,788,758...23,795,298

G

signaling lymphocytic activation molecule family member 1

decreases expression

ISO

Eugenol results in decreased expression of SLAMF1 mRNA

NCBI chr13:86,802,708...86,837,890
Ensembl chr13:86,802,708...86,837,890

G

solute carrier family 12 member 1

increases expression

EXP

Eugenol results in increased expression of SLC12A1 protein

NCBI chr 3:132,859,581...132,936,354
Ensembl chr 3:132,859,590...132,936,340

G

solute carrier family 12 member 4

increases expression

EXP

Eugenol results in increased expression of SLC12A4 protein

NCBI chr19:50,748,268...50,770,217
Ensembl chr19:50,748,279...50,770,259

G

solute carrier family 16 member 10

increases expression

ISO

Eugenol results in increased expression of SLC16A10 mRNA

NCBI chr20:45,014,229...45,122,392
Ensembl chr20:45,014,235...45,122,358

G

solute carrier family 22 member 12

increases expression

EXP

Eugenol results in increased expression of SLC22A12 protein

NCBI chr 1:213,274,266...213,282,793
Ensembl chr 1:213,274,275...213,281,380

G

solute carrier family 22 member 2

increases expression

EXP

Eugenol results in increased expression of SLC22A2 protein

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 6

increases expression

EXP

Eugenol results in increased expression of SLC22A6 protein

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311

G

solute carrier family 22 member 8

increases expression

EXP

Eugenol results in increased expression of SLC22A8 protein

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

solute carrier family 23 member 1

increases expression

EXP

Eugenol results in increased expression of SLC23A1 protein

NCBI chr18:27,490,549...27,504,563
Ensembl chr18:27,490,374...27,504,702

G

solute carrier family 25 member 1

increases expression

EXP

Eugenol results in increased expression of SLC25A1 protein

NCBI chr11:96,560,054...96,563,071
Ensembl chr11:96,560,041...96,565,052

G

solute carrier family 25 member 10

increases expression

EXP

Eugenol results in increased expression of SLC25A10 protein

NCBI chr10:106,264,396...106,271,895
Ensembl chr10:106,264,344...106,273,498

G

solute carrier family 25 member 11

increases expression

EXP

Eugenol results in increased expression of SLC25A11 protein

NCBI chr10:55,856,209...55,859,060
Ensembl chr10:55,855,979...55,859,060

G

solute carrier family 25 member 15

increases expression

EXP

Eugenol results in increased expression of SLC25A15 protein

NCBI chr16:76,334,037...76,357,325
Ensembl chr16:76,324,288...76,357,321

G

solute carrier family 25 member 20

increases expression

EXP

Eugenol results in increased expression of SLC25A20 protein

NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027

G

solute carrier family 25 member 4

increases expression

EXP

Eugenol results in increased expression of SLC25A4 protein

NCBI chr16:52,805,521...52,809,316
Ensembl chr16:52,805,523...52,811,700

G

solute carrier family 25 member 5

increases expression

EXP

Eugenol results in increased expression of SLC25A5 protein

NCBI chr X:120,897,616...120,900,683
Ensembl chr X:120,897,563...120,900,688

G

solute carrier family 26 member 1

increases expression

EXP

Eugenol results in increased expression of SLC26A1 protein

NCBI chr14:1,180,465...1,190,257
Ensembl chr14:1,184,649...1,190,255

G

solute carrier family 27 member 2

increases expression

EXP

Eugenol results in increased expression of SLC27A2 protein

NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581

G

solute carrier family 2 member 3

increases expression

ISO

Eugenol results in increased expression of SLC2A3 mRNA

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186

G

solute carrier family 2 member 4

increases expression

ISO
EXP

Eugenol results in increased expression of SLC2A4 mRNA

PMID:20724125 PMID:21870829

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 34 member 1

increases expression

EXP

Eugenol results in increased expression of SLC34A1 protein

NCBI chr17:9,224,010...9,238,983
Ensembl chr17:9,224,010...9,238,983

G

solute carrier family 34 member 3

increases expression

EXP

Eugenol results in increased expression of SLC34A3 protein

NCBI chr 3:28,442,455...28,447,997
Ensembl chr 3:28,442,457...28,447,997

G

solute carrier family 3 member 1

increases expression

EXP

Eugenol results in increased expression of SLC3A1 protein

NCBI chr 6:15,361,037...15,396,695
Ensembl chr 6:15,361,046...15,394,775

G

solute carrier family 4 member 1 (Diego blood group)

increases expression

EXP

Eugenol results in increased expression of SLC4A1 protein

NCBI chr10:87,807,010...87,823,274
Ensembl chr10:87,807,013...87,823,258

G

solute carrier family 5 member 1

increases expression

EXP

Eugenol results in increased expression of SLC5A1 protein

NCBI chr14:81,778,495...81,843,084
Ensembl chr14:81,778,348...81,846,624

G

solute carrier family 5 member 8

increases expression

EXP

Eugenol results in increased expression of SLC5A8 protein

NCBI chr 7:25,160,280...25,201,185
Ensembl chr 7:25,159,897...25,204,419

G

solute carrier family 6 member 18

increases expression

EXP

Eugenol results in increased expression of SLC6A18 protein

NCBI chr 1:31,436,577...31,450,478
Ensembl chr 1:31,436,630...31,450,478

G

solute carrier family 6 member 19

increases expression

EXP

Eugenol results in increased expression of SLC6A19 protein

NCBI chr 1:31,414,744...31,434,932
Ensembl chr 1:31,414,744...31,433,517

G

solute carrier family 7 member 11

increases expression

ISO

Eugenol results in increased expression of SLC7A11 mRNA

PMID:26198647 PMID:30806763

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

SRA stem-loop interacting RNA binding protein

decreases expression

EXP

Eugenol results in decreased expression of SLIRP protein

NCBI chr 6:112,819,684...112,828,715
Ensembl chr 6:112,819,448...112,828,715

G

small nuclear ribonucleoprotein 13

decreases expression

EXP

Eugenol results in decreased expression of SNU13 protein

NCBI chr 7:115,445,415...115,451,008
Ensembl chr 1:269,702,002...269,703,004
Ensembl chr 7:269,702,002...269,703,004

G

superoxide dismutase 1

increases expression
decreases expression
multiple interactions

ISO

Eugenol results in increased expression of SOD1 mRNA
Eugenol results in decreased expression of SOD1 mRNA; Eugenol results in decreased expression of SOD1 protein
Acetylcysteine promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]

PMID:16101137 PMID:20566472

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

increases expression
decreases expression
multiple interactions

ISO

Eugenol results in increased expression of SOD2 mRNA
Eugenol results in decreased expression of SOD2 mRNA; Eugenol results in decreased expression of SOD2 protein
Acetylcysteine promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]

PMID:16101137 PMID:20566472

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

superoxide dismutase 3

increases expression

ISO

Eugenol results in increased expression of SOD3 mRNA

NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125

G

sequestosome 1

increases expression

ISO

Eugenol results in increased expression of SQSTM1 mRNA

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

sulfiredoxin 1

increases expression

ISO

Eugenol results in increased expression of SRXN1 mRNA

PMID:20566472 PMID:26198647

NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765

G

signal sequence receptor subunit 1

increases expression

EXP

Eugenol results in increased expression of SSR1 protein

NCBI chr17:27,039,203...27,067,352
Ensembl chr17:27,039,269...27,067,348

G

signal transducer and activator of transcription 1

decreases expression

ISO

Eugenol results in decreased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 4

increases expression

ISO

Eugenol results in increased expression of STAT4 mRNA

NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 5B

increases expression

ISO

Eugenol results in increased expression of STAT5B mRNA

NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990

G

STT3 oligosaccharyltransferase complex catalytic subunit B

increases expression

EXP

Eugenol results in increased expression of STT3B protein

NCBI chr 8:123,806,836...123,872,179
Ensembl chr 8:123,795,983...123,872,180

G

sulfotransferase family 1C member 3

increases sulfation

ISO

SULT1C1 protein results in increased sulfation of Eugenol

NCBI chr 9:7,548,839...7,594,299
Ensembl chr 9:7,548,622...7,594,295

G

transgelin

increases expression

EXP

Eugenol results in increased expression of TAGLN protein

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563

G

threonine aldolase 1

increases expression

EXP

Eugenol results in increased expression of THA1 protein

NCBI chr10:103,593,363...103,598,851
Ensembl chr10:103,593,098...103,604,792

G

translocase of inner mitochondrial membrane 13

increases expression

EXP

Eugenol results in increased expression of TIMM13 protein

NCBI chr 7:9,459,490...9,460,849
Ensembl chr 7:9,459,582...9,460,862

G

translocase of inner mitochondrial membrane 8A1

decreases expression

EXP

Eugenol results in decreased expression of TIMM8A protein

NCBI chr X:102,011,206...102,015,444
Ensembl chr X:102,011,206...102,015,444

G

TIMP metallopeptidase inhibitor 2

multiple interactions

EXP

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein]

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

toll-like receptor 4

increases expression

ISO

Eugenol results in increased expression of TLR4 mRNA

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

transmembrane protein 109

increases expression

EXP

Eugenol results in increased expression of TMEM109 protein

NCBI chr 1:216,944,516...216,955,091
Ensembl chr 1:216,944,519...216,955,138

G

transmembrane protein 33

increases expression

EXP

Eugenol results in increased expression of TMEM33 protein

NCBI chr14:41,242,358...41,264,586
Ensembl chr14:41,242,358...41,264,586

G

tumor necrosis factor

multiple interactions
increases expression
affects expression

ISO
EXP

Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
Eugenol results in increased expression of TNF mRNA
Eugenol affects the expression of TNF mRNA
Eugenol inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Eugenol inhibits the reaction [Thioacetamide results in increased activity of TNF protein]
[Methoxychlor co-treated with Eugenol] results in increased expression of TNF protein; [Parathion co-treated with Eugenol] results in increased expression of TNF protein; Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Bacterial Toxins results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of TNF protein]

PMID:10871845 PMID:12963494 PMID:17509409 PMID:20036707 PMID:20043298 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

increases expression

ISO

Eugenol results in increased expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF alpha induced protein 6

increases expression

ISO

Eugenol results in increased expression of TNFAIP6 mRNA

PMID:17374397 PMID:20713136

NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796

G

translocase of outer mitochondrial membrane 22

increases expression

EXP

Eugenol results in increased expression of TOMM22 protein

NCBI chr 7:113,103,863...113,109,056
Ensembl chr 7:113,103,860...113,109,053

G

tumor protein p53

multiple interactions
increases mutagenesis
increases expression

EXP
ISO

Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TP53 protein]
Eugenol results in increased mutagenesis of TP53 gene
Eugenol results in increased expression of TRP53 mRNA; Eugenol results in increased expression of TRP53 protein
Eugenol promotes the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 protein]

PMID:15576237 PMID:19851710 PMID:20043298 PMID:20537511

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p63

decreases expression

ISO

Eugenol results in decreased expression of TP63 mRNA

NCBI chr11:88,343,647...88,554,543
Ensembl chr11:88,343,651...88,554,177

G

transient receptor potential cation channel, subfamily A, member 1

multiple interactions
increases activity

EXP

[2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide binds to and results in decreased activity of TRPA1 protein] which results in decreased susceptibility to Eugenol
Eugenol results in increased activity of TRPA1 protein

NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325

G

transient receptor potential cation channel, subfamily V, member 3

multiple interactions
increases activity

ISO
EXP

Eugenol binds to and results in increased activity of TRPV3 protein
[Eugenol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium; Eugenol binds to and results in increased activity of TRPV3 protein
[Eugenol results in increased activity of TRPV3 protein] which results in increased transport of Calcium

PMID:16617338 PMID:20086034 PMID:21593771

NCBI chr10:58,382,054...58,413,657
Ensembl chr10:58,382,054...58,411,800

G

transient receptor potential cation channel, subfamily V, member 4

increases expression

EXP

Eugenol results in increased expression of TRPV4 protein

NCBI chr12:47,599,161...47,638,143
Ensembl chr12:47,599,035...47,638,143

G

twinfilin actin-binding protein 1

decreases expression

EXP

Eugenol results in decreased expression of TWF1 protein

NCBI chr 7:127,595,210...127,607,821
Ensembl chr 7:127,595,210...127,607,105

G

thioredoxin 2

increases expression

ISO

Eugenol results in increased expression of TXN2 mRNA

NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022

G

thioredoxin reductase 1

increases expression

ISO

Eugenol results in increased expression of TXNRD1 mRNA

PMID:20566472 PMID:23445166

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

thioredoxin reductase 2

increases expression

ISO

Eugenol results in increased expression of TXNRD2 mRNA

NCBI chr11:96,024,321...96,072,475
Ensembl chr11:96,024,324...96,072,475

G

UDP-glucose 6-dehydrogenase

increases expression

ISO

Eugenol results in increased expression of UGDH mRNA

NCBI chr14:43,202,480...43,226,002
Ensembl chr14:43,202,356...43,226,629

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation
increases expression

ISO
EXP

UGT1A1 protein results in increased glucuronidation of Eugenol
Eugenol results in increased expression of UGT1A1 protein

PMID:14557274 PMID:39793947

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A6a

increases expression

ISO

Eugenol results in increased expression of UGT1A6 mRNA

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of Eugenol

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases metabolic processing

ISO

UGT2B17 protein results in increased metabolism of Eugenol

NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

EXP

UGT2B15 protein results in increased metabolism of Eugenol

NCBI chr14:21,122,866...21,138,450
Ensembl chr14:21,122,861...21,138,467

G

uromodulin

increases expression

EXP

Eugenol results in increased expression of UMOD protein

NCBI chr 1:183,247,676...183,261,665
Ensembl chr 1:183,247,674...183,261,030

G

ubiquinol-cytochrome c reductase, complex III subunit VII

increases expression

EXP

Eugenol results in increased expression of UQCRQ protein

NCBI chr10:38,086,691...38,093,871
Ensembl chr10:38,087,715...38,089,996

G

voltage-dependent anion channel 2

increases expression

EXP

Eugenol results in increased expression of VDAC2 protein

NCBI chr15:2,512,214...2,526,105
Ensembl chr15:2,512,216...2,532,229

G

voltage-dependent anion channel 3

increases expression

EXP

Eugenol results in increased expression of VDAC3 protein

NCBI chr16:76,137,489...76,153,933
Ensembl chr16:76,137,504...76,155,304

G

vitamin D receptor

increases expression

ISO

Eugenol results in increased expression of VDR mRNA

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreases expression

EXP

Eugenol results in decreased expression of YWHAE protein

NCBI chr10:61,082,934...61,120,618
Ensembl chr10:61,106,716...61,114,291

G

zinc finger and BTB domain containing 17

decreases expression

ISO

Eugenol results in decreased expression of ZBTB17 mRNA

NCBI chr 5:159,036,482...159,057,580
Ensembl chr 5:159,036,515...159,057,581

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BRCA1, DNA repair associated

multiple interactions
increases expression

ISO

Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein]

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

caspase 3

multiple interactions
increases activity

ISO

CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

cyclin D1

multiple interactions
increases expression

ISO

Curcumin inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]
Furazolidone results in increased expression of CCND1 mRNA; Furazolidone results in increased expression of CCND1 protein

PMID:23112108 PMID:26095818 PMID:27996348

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D3

multiple interactions
increases expression

ISO

GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]
Furazolidone results in increased expression of CCND3 mRNA; Furazolidone results in increased expression of CCND3 protein

PMID:23112108 PMID:26095818

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin-dependent kinase 6

increases expression
multiple interactions

ISO

Furazolidone results in increased expression of CDK6 mRNA; Furazolidone results in increased expression of CDK6 protein
GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]

PMID:23112108 PMID:26095818

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression
decreases expression

ISO

CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Furazolidone promotes the reaction [Cycloheximide results in decreased expression of CDKN1A protein]
Furazolidone results in increased expression of CDKN1A mRNA
Furazolidone results in decreased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

checkpoint kinase 1

multiple interactions
increases expression

ISO

Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein]

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity

EXP

Furazolidone results in increased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

ISO

Curcumin inhibits the reaction [Furazolidone results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions
increases expression

ISO

GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]
Furazolidone results in increased expression of GADD45A

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

heme oxygenase 1

multiple interactions
increases expression

ISO

CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]

PMID:26687534 PMID:27996348

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

ISO

Furazolidone results in increased expression of HSPA5 protein
Curcumin inhibits the reaction [Furazolidone results in increased expression of HSPA5 protein]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

insulin-like growth factor 1

multiple interactions

ISO

IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

ISO

Furazolidone results in increased phosphorylation of MAPK1 protein
Curcumin inhibits the reaction [Furazolidone results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

ISO

CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]

PMID:26687534 PMID:27996348

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

ISO

CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]
Furazolidone results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity
increases expression

ISO

harmalol results in increased activity of CASP3 protein
harmalol results in increased expression of CASP3 mRNA

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases stability
decreases activity

ISO

[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein]; harmalol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
harmalol results in decreased stability of CYP1A1 protein
harmalol results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

tumor protein p53

increases expression

ISO

harmalol results in increased expression of TP53 mRNA; harmalol results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

ISO

AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

caspase 3

increases cleavage
increases expression

ISO

harman results in increased cleavage of CASP3 protein
harman results in increased expression of CASP3 mRNA

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases expression

ISO

harman results in increased expression of CASP7 mRNA

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 9

increases expression

ISO

harman results in increased expression of CASP9 mRNA

Ensembl chr 5:159,391,188...159,409,648

G

catalase

decreases activity

ISO

harman results in decreased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
increases activity

ISO
EXP

AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [harman results in increased activity of CYP1A1 protein]
harman results in increased expression of CYP1A1 mRNA; harman results in increased expression of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

heme oxygenase 1

increases expression

ISO

harman results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

monoamine oxidase A

decreases activity

ISO

harman results in decreased activity of MAOA protein

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

NFE2 like bZIP transcription factor 2

increases expression

ISO

harman results in increased expression of NFE2L2 protein

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NAD(P)H quinone dehydrogenase 1

increases expression

ISO

harman results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

harman results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

solute carrier family 22 member 1

multiple interactions
decreases activity

ISO

harman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
harman results in decreased activity of SLC22A1 protein

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

decreases activity
multiple interactions

ISO

harman results in decreased activity of SLC22A2 protein
harman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

trace-amine-associated receptor 1

increases activity
multiple interactions

ISO

harman results in increased activity of TAAR1 protein
[harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP

NCBI chr 1:23,336,978...23,337,976
Ensembl chr 1:23,335,165...23,353,981

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

ISO

Harmine results in decreased activity of ACHE protein

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

adrenoceptor beta 1

multiple interactions

ISO

Harmine affects the reaction [Epinephrine results in increased activity of ADRB1 protein]

NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237

G

adrenoceptor beta 2

multiple interactions

ISO

Harmine inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

aryl hydrocarbon receptor

multiple interactions

ISO

Harmine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

axin 2

multiple interactions

ISO

Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA]

NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575

G

Bcl2-like 11

multiple interactions

ISO

Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein]

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

calcium/calmodulin-dependent protein kinase II delta

decreases expression

EXP

harmine decreases expression of camk2d protein after myocardial infarction in rat heart left ventricle

RGD

NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:217,698,551...217,960,276

G

cyclin A1

increases expression

ISO

Harmine results in increased expression of CCNA1 mRNA; Harmine results in increased expression of CCNA1 protein

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cyclin E2

increases expression

ISO

Harmine results in increased expression of CCNE2 mRNA; Harmine results in increased expression of CCNE2 protein

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

cell division cycle 25A

increases expression

ISO

Harmine results in increased expression of CDC25A mRNA

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188

G

cell division cycle 25C

increases expression

ISO

Harmine results in increased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cyclin-dependent kinase 1

increases expression

ISO

Harmine results in increased expression of CDK1 mRNA; Harmine results in increased expression of CDK1 protein

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase inhibitor 1B

decreases phosphorylation

EXP

Harmine results in decreased phosphorylation of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cyclin-dependent kinase inhibitor 1C

decreases expression

ISO

Harmine results in decreased expression of CDKN1C mRNA; Harmine results in decreased expression of CDKN1C protein

NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:208,084,787...208,087,498

G

cyclin-dependent kinase inhibitor 2A

decreases expression

ISO

Harmine results in decreased expression of CDKN2A mRNA; Harmine results in decreased expression of CDKN2A protein

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248

G

cyclin-dependent kinase inhibitor 2B

decreases expression

ISO

Harmine results in decreased expression of CDKN2B mRNA

NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:109,114,322...109,134,855

G

chromodomain helicase DNA binding protein 4

multiple interactions
increases phosphorylation

ISO

AZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]

NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:159,584,654...159,617,866

G

cell death-inducing DFFA-like effector a

multiple interactions
increases expression

ISO

Harmine affects the reaction [Dietary Fats affects the expression of CIDEA mRNA]
Harmine results in increased expression of CIDEA protein

NCBI chr18:63,164,817...63,190,384
Ensembl chr18:63,164,099...63,190,382

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
decreases stability

ISO

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Harmine results in decreased stability of CYP1A1 protein]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Harmine results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

iodothyronine deiodinase 2

increases expression

ISO

Harmine results in increased expression of DIO2 protein

NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594

G

dual specificity tyrosine phosphorylation regulated kinase 1A

multiple interactions
decreases expression
affects binding
decreases activity

ISO
EXP

Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]
harmine decreases expression of dyrk1a protein after myocardial infarction in rat heart left ventricle
Harmine binds to DYRK1A protein
Harmine results in decreased activity of DYRK1A protein

CTD
RGD

PMID:21573099 PMID:25751815 PMID:26067684

NCBI chr11:47,360,824...47,479,033
Ensembl chr11:47,360,850...47,479,033

G

E2F transcription factor 1

increases expression

ISO

Harmine results in increased expression of E2F1 mRNA; Harmine results in increased expression of E2F1 protein

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

E2F transcription factor 2

increases expression

ISO

Harmine results in increased expression of E2F2 mRNA; Harmine results in increased expression of E2F2 protein

NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:153,682,789...153,706,087

G

E2F transcription factor 7

increases expression

ISO

Harmine results in increased expression of E2F7 mRNA

NCBI chr 7:48,036,881...48,079,055
Ensembl chr 7:48,037,749...48,079,055

G

E2F transcription factor 8

increases expression

ISO

Harmine results in increased expression of E2F8 mRNA

NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:107,701,985...107,720,009

G

fatty acid binding protein 4

multiple interactions

ISO

[phenylamil co-treated with Harmine] results in increased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

forkhead box M1

increases expression

ISO

Harmine results in increased expression of FOXM1 mRNA; Harmine results in increased expression of FOXM1 protein

NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:163,325,614...163,337,172

G

inhibitor of DNA binding 2

multiple interactions

ISO

Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

insulin 1

multiple interactions

ISO

Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin 2

increases expression

ISO

Harmine results in increased expression of INS mRNA

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

leptin receptor

multiple interactions

ISO

Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein]

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215

G

MAF bZIP transcription factor A

increases expression

ISO

Harmine results in increased expression of MAFA mRNA; Harmine results in increased expression of MAFA protein

NCBI chr 7:109,313,021...109,315,813
Ensembl chr 7:109,313,121...109,315,760

G

monoamine oxidase A

decreases activity

EXP
ISO

Harmine results in decreased activity of MAOA protein

PMID:24373881 PMID:28302559

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

mitogen activated protein kinase 1

increases phosphorylation

ISO

Harmine results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation

ISO

Harmine results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

microtubule-associated protein tau

multiple interactions

ISO

Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

MYC proto-oncogene, bHLH transcription factor

increases expression

ISO

Harmine results in increased expression of MYC protein

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

nuclear factor of activated T-cells 1

affects localization

ISO

Harmine affects the localization of NFATC1 protein

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

nuclear factor of activated T-cells 2

affects localization

ISO

Harmine affects the localization of NFATC2 protein

NCBI chr 3:177,615,189...177,747,493
Ensembl chr 3:177,618,314...177,747,380

G

nuclear factor of activated T-cells 3

affects localization

ISO

Harmine affects the localization of NFATC3 protein

NCBI chr19:50,870,464...50,944,992
Ensembl chr19:50,870,489...50,944,992

G

nuclear factor of activated T-cells 4

affects localization

ISO

Harmine affects the localization of NFATC4 protein

NCBI chr15:33,256,912...33,284,522
Ensembl chr15:33,274,153...33,285,582

G

NK6 homeobox 1

increases expression

ISO

Harmine results in increased expression of NKX6.1 mRNA; Harmine results in increased expression of NKX6.1 protein

NCBI chr14:8,274,238...8,281,171
Ensembl chr14:8,274,238...8,281,163

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

pancreatic and duodenal homeobox 1

increases expression

ISO

Harmine results in increased expression of PDX1 mRNA; Harmine results in increased expression of PDX1 protein

NCBI chr12:12,793,957...12,799,156
Ensembl chr12:12,793,957...12,799,156

G

phospholamban

increases expression

EXP

harmine increases expression of Pln protein after myocardial infarction in rat heart left ventricle

RGD

NCBI chr20:33,166,512...33,182,241
Ensembl chr20:33,172,494...33,182,241

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

ISO

[phenylamil co-treated with Harmine] results in increased expression of PPARG mRNA
Harmine results in increased expression of PPARG protein

PMID:20519739 PMID:27805061

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

increases expression
multiple interactions

ISO

Harmine results in increased expression of PPARGC1A protein
Harmine affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

PR/SET domain 16

increases expression
multiple interactions

ISO

Harmine results in increased expression of PRDM16 protein
Harmine affects the reaction [Dietary Fats affects the expression of PRDM16 mRNA]

NCBI chr 5:170,162,275...170,486,371
Ensembl chr 5:170,162,275...170,485,804

G

uncoupling protein 1

increases expression
multiple interactions

ISO

Harmine results in increased expression of UCP1 mRNA; Harmine results in increased expression of UCP1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; AZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; Harmine affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]; N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]

NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420

G

Wnt family member 3A

multiple interactions

ISO

Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]; Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA]

NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,533,734...44,577,919

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member B1

increases reduction

ISO

AKR1B1 protein results in increased reduction of Isatin

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315

G

aldo-keto reductase family 1 member B15

multiple interactions

EXP

[AKR1B8 protein co-treated with NADP] affects the reduction of Isatin

NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:63,960,880...63,978,349

G

aldo-keto reductase family 7, member A2

affects reduction
increases reduction

ISO

Isatin affects the reduction of AKR7A5 protein
AKR7A2 protein results in increased reduction of Isatin

PMID:10510318 PMID:12604212

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:156,835,551...156,844,109

G

caspase 3

multiple interactions

ISO

[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

ISO

[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

carbonyl reductase 1

multiple interactions

ISO

[S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of Isatin]

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

carbonyl reductase 3

increases metabolic processing

ISO

CBR3 protein results in increased metabolism of Isatin

NCBI chr11:46,478,295...46,486,555
Ensembl chr11:46,478,274...46,486,558

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cytochrome c, somatic

multiple interactions

ISO

[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein; [Copper binds to Isatin binds to trimethylenediamine] which affects the localization of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases expression

ISO

Isatin results in increased expression of CYP2D6 mRNA

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

ISO

Isatin results in increased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

dehydrogenase/reductase 11

increases reduction

ISO

DHRS11 protein results in increased reduction of Isatin

NCBI chr10:70,195,637...70,205,735
Ensembl chr10:70,195,637...70,205,893

G

dehydrogenase/reductase 7

increases reduction

ISO

DHRS7 protein results in increased reduction of Isatin

NCBI chr 6:97,068,149...97,083,744
Ensembl chr 6:97,068,149...97,083,744

G

interleukin 10

multiple interactions

EXP

Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

myeloperoxidase

multiple interactions

EXP

Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

prostaglandin-endoperoxide synthase 2

multiple interactions

EXP

Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

superoxide dismutase 1

multiple interactions

ISO

SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine]; SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to trimethylenediamine]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

tumor necrosis factor

multiple interactions

EXP

Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions

ISO

[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of TP53 protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 13

decreases expression

ISO

kojic acid results in decreased expression of ABCA13 mRNA

NCBI chr14:88,087,146...88,589,868
Ensembl chr14:88,087,801...88,589,392

G

ATP binding cassette subfamily C member 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in increased expression of ABCC2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of ABCC2 mRNA

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 6

multiple interactions

ISO
EXP

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCC6 mRNA
[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of ABCC6 mRNA

PMID:17917374 PMID:18544905

NCBI chr 1:105,583,681...105,637,895
Ensembl chr 1:105,583,682...105,637,895

G

ATP binding cassette subfamily C member 9

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCC9 mRNA

NCBI chr 4:177,262,848...177,386,837
Ensembl chr 4:177,262,848...177,386,348

G

ATP binding cassette subfamily D member 1

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCD1 mRNA

NCBI chr X:156,579,669...156,601,448
Ensembl chr X:156,579,785...156,601,446

G

ATP binding cassette subfamily F member 2

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCF2 mRNA

NCBI chr 4:11,485,865...11,500,067
Ensembl chr 4:11,487,395...11,500,053

G

abhydrolase domain containing 1

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of ABHD1 mRNA

NCBI chr 6:31,142,476...31,147,464
Ensembl chr 6:31,142,476...31,147,464

G

alkaline ceramidase 3

increases expression

ISO

kojic acid results in increased expression of ACER3 mRNA

NCBI chr 1:161,915,397...162,017,802
Ensembl chr 1:161,915,397...162,017,912

G

aminocarboxymuconate semialdehyde decarboxylase

decreases expression

ISO

kojic acid results in decreased expression of ACMSD mRNA

NCBI chr13:41,752,894...41,798,427
Ensembl chr13:41,752,875...41,798,427

G

activin A receptor like type 1

decreases expression

ISO

kojic acid results in decreased expression of ACVRL1 mRNA

NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:134,118,024...134,135,305

G

adrenoceptor beta 3

decreases expression

ISO

kojic acid results in decreased expression of ADRB3 mRNA

NCBI chr16:71,544,603...71,547,410
Ensembl chr16:71,542,567...71,547,420

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

increases expression

ISO

kojic acid results in increased expression of AGAP3 mRNA

NCBI chr 4:11,567,191...11,617,610
Ensembl chr 4:11,567,191...11,617,285

G

AGBL carboxypeptidase 4

decreases expression

ISO

kojic acid results in decreased expression of AGBL4 mRNA

NCBI chr 5:130,483,551...131,762,906

G

AHNAK nucleoprotein

decreases expression

ISO

kojic acid results in decreased expression of AHNAK mRNA

NCBI chr 1:215,311,289...215,400,010
Ensembl chr 1:215,321,931...215,400,675

G

AKT serine/threonine kinase 1

decreases expression

ISO

kojic acid results in decreased expression of AKT1 mRNA

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

alkaline phosphatase, intestinal

decreases expression

ISO

kojic acid results in decreased expression of ALPI mRNA

NCBI chr 9:95,221,314...95,224,780
Ensembl chr 9:95,221,314...95,224,780

G

amelotin

decreases expression

ISO

kojic acid results in decreased expression of AMTN mRNA

NCBI chr14:19,932,664...19,945,223
Ensembl chr14:19,932,665...19,945,223

G

annexin A1

decreases expression

ISO

kojic acid results in decreased expression of ANXA1 mRNA

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831

G

annexin A5

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ANXA5 mRNA

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

ISO

kojic acid results in decreased expression of AP1S1 mRNA

NCBI chr12:25,261,958...25,272,483
Ensembl chr12:25,262,036...25,272,483

G

apolipoprotein B mRNA editing enzyme catalytic subunit 1

decreases expression

ISO

kojic acid results in decreased expression of APOBEC1 mRNA

NCBI chr 4:157,472,879...157,500,496
Ensembl chr 4:157,472,868...157,498,909

G

amyloid beta precursor protein

increases expression

ISO

kojic acid results in increased expression of APP mRNA

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

aprataxin

decreases expression

ISO

kojic acid results in decreased expression of APTX mRNA

NCBI chr 5:60,593,338...60,618,946
Ensembl chr 5:60,597,648...60,618,790

G

aquaporin 1

increases expression

ISO

kojic acid results in increased expression of AQP1 mRNA

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504

G

ARF interacting protein 2

decreases expression

ISO

kojic acid results in decreased expression of ARFIP2 mRNA

NCBI chr 1:169,387,484...169,392,290
Ensembl chr 1:169,387,485...169,392,166

G

Rho guanine nucleotide exchange factor 16

decreases expression

ISO

kojic acid results in decreased expression of ARHGEF16 mRNA

NCBI chr 5:170,126,573...170,148,624
Ensembl chr 5:170,126,575...170,148,624

G

ARF like GTPase 6 interacting protein 5

increases expression

ISO

kojic acid results in increased expression of ARL6IP5 mRNA

NCBI chr 4:131,365,320...131,395,311
Ensembl chr 4:131,367,289...131,400,130

G

asparagine synthetase domain containing 1

decreases expression

ISO

kojic acid results in decreased expression of ASNSD1 mRNA

NCBI chr 9:55,618,799...55,631,064
Ensembl chr 9:55,618,799...55,631,064

G

activating transcription factor 6 beta

decreases expression

ISO

kojic acid results in decreased expression of ATF6B mRNA

NCBI chr20:4,095,534...4,103,534
Ensembl chr20:4,095,534...4,106,032

G

ATM serine/threonine kinase

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

beta-1,4-N-acetyl-galactosaminyl transferase 4

decreases expression

ISO

kojic acid results in decreased expression of B4GALNT4 mRNA

NCBI chr 1:205,600,989...205,611,889
Ensembl chr 1:205,600,989...205,611,889

G

BAG cochaperone 5

decreases expression

ISO

kojic acid results in decreased expression of BAG5 mRNA

NCBI chr 6:136,589,623...136,593,278
Ensembl chr 6:136,584,741...136,598,492

G

BCL2-related protein A1

increases expression

ISO

kojic acid results in increased expression of BCL2A1 mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

Bcl2-like 2

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of BCL2L2 mRNA

NCBI chr15:32,326,686...32,337,834
Ensembl chr15:32,326,020...32,335,379

G

baculoviral IAP repeat-containing 2

decreases expression

ISO

kojic acid results in decreased expression of BIRC2 mRNA

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

bone morphogenetic protein 5

decreases expression

ISO

kojic acid results in decreased expression of BMP5 mRNA

NCBI chr 8:85,397,629...85,520,374
Ensembl chr 8:85,396,925...85,520,189

G

BR serine/threonine kinase 1

decreases expression

ISO

kojic acid results in decreased expression of BRSK1 mRNA

NCBI chr 1:78,162,944...78,193,598
Ensembl chr 1:78,163,341...78,188,922

G

bone marrow stromal cell antigen 2

decreases expression

ISO

kojic acid results in decreased expression of BST2 mRNA

NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967

G

similar to human chromosome 1 open reading frame 54

increases expression

ISO

kojic acid results in increased expression of C1ORF54 mRNA

NCBI chr 2:186,113,922...186,124,637
Ensembl chr 2:186,113,922...186,124,335

G

similar to human chromosome 1 open reading frame 87

decreases expression

ISO

kojic acid results in decreased expression of C1ORF87 mRNA

NCBI chr 5:116,458,224...116,527,281
Ensembl chr 5:116,458,270...116,527,231

G

carbonic anhydrase 13

increases expression

ISO

kojic acid results in increased expression of CAR13 mRNA

NCBI chr 2:88,649,643...88,680,763
Ensembl chr 2:88,649,625...88,680,763

G

carbonic anhydrase 14

increases expression

ISO

kojic acid results in increased expression of CA14 mRNA

NCBI chr 2:186,131,196...186,138,164
Ensembl chr 2:186,129,341...186,138,863

G

calcium binding protein 39-like

increases expression

ISO

kojic acid results in increased expression of CAB39L mRNA

NCBI chr15:37,782,778...37,885,191
Ensembl chr15:37,782,870...37,919,742

G

calreticulin

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CALR mRNA

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236

G

caspase 4

multiple interactions

EXP

[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CASP4 mRNA; Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CASP4 mRNA]

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727

G

caspase 8

multiple interactions

EXP

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

catalase

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cell division cycle and apoptosis regulator 1

increases expression

ISO

kojic acid results in increased expression of CCAR1 mRNA

NCBI chr20:31,228,624...31,271,233
Ensembl chr20:31,228,624...31,271,227

G

coiled-coil domain containing 144A

decreases expression

ISO

kojic acid results in decreased expression of CCDC144A mRNA

NCBI chr17:59,503,255...59,542,745
Ensembl chr17:59,503,243...59,542,741

G

coiled-coil domain containing 50

increases expression

ISO

kojic acid results in increased expression of CCDC50 mRNA

NCBI chr11:86,837,624...86,900,164
Ensembl chr11:86,837,624...86,899,980

G

C-C motif chemokine ligand 21

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCL21A mRNA

NCBI chr 5:61,776,411...61,777,515
Ensembl chr 5:61,776,413...61,777,540

G

C-C motif chemokine ligand 3

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

cyclin B1

increases expression

ISO

kojic acid results in increased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin C

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCNC mRNA

NCBI chr 5:40,063,589...40,081,731
Ensembl chr 5:40,063,623...40,093,370

G

cyclin D1

multiple interactions

EXP
ISO

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CCND1 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCND1 mRNA

PMID:17917374 PMID:18544905

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin G1

multiple interactions

EXP
ISO

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in increased expression of CCNG1 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCNG1 mRNA

PMID:17917374 PMID:18544905

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

cell cycle progression 1

decreases expression

ISO

kojic acid results in decreased expression of CCPG1 mRNA

NCBI chr 8:82,600,677...82,633,082
Ensembl chr 8:82,600,536...82,660,246

G

C-C motif chemokine receptor 4

decreases expression

ISO

kojic acid results in decreased expression of CCR4 mRNA

NCBI chr 8:123,054,505...123,060,244
Ensembl chr 8:123,054,324...123,077,642

G

CD22 molecule

decreases expression

ISO

kojic acid results in decreased expression of CD22 mRNA

NCBI chr 1:95,243,785...95,270,430
Ensembl chr 1:95,244,868...95,259,730

G

CD274 molecule

increases expression

ISO

kojic acid results in increased expression of CD274 mRNA

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951

G

CD3 gamma subunit of T-cell receptor complex

decreases expression

ISO

kojic acid results in decreased expression of CD3G mRNA

NCBI chr 8:54,177,572...54,184,087
Ensembl chr 8:54,177,977...54,183,918

G

CDAN1 interacting nuclease 1

increases expression

ISO

kojic acid results in increased expression of CDIN1 mRNA

NCBI chr 3:122,895,754...123,101,099
Ensembl chr 3:122,895,824...123,101,099

G

cyclin-dependent kinase 10

decreases expression

ISO

kojic acid results in decreased expression of CDK10 mRNA

NCBI chr19:68,168,040...68,184,923
Ensembl chr19:68,169,874...68,177,599

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO
EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CDKN1A mRNA
[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CDKN1A mRNA

PMID:17917374 PMID:18544905

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

EXP

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA; [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

CEA cell adhesion molecule 1

decreases expression

ISO

kojic acid results in decreased expression of CEACAM1 mRNA

NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798

G

CCAAT/enhancer binding protein delta

increases expression

ISO

kojic acid results in increased expression of CEBPD mRNA

NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824

G

centromere protein Q

decreases expression

ISO

kojic acid results in decreased expression of CENPQ mRNA

NCBI chr 9:27,454,339...27,469,371
Ensembl chr 9:27,454,252...27,469,366

G

centrosomal protein 192

increases expression

ISO

kojic acid results in increased expression of CEP192 mRNA

NCBI chr18:63,643,816...63,728,264
Ensembl chr18:63,646,163...63,728,264

G

centrosomal protein 72

increases expression

ISO

kojic acid results in increased expression of CEP72 mRNA

NCBI chr 1:31,053,884...31,083,863
Ensembl chr 1:31,053,914...31,083,863

G

carboxylesterase 1D

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CES1 mRNA

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

checkpoint kinase 2

multiple interactions

EXP

[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CHEK2 mRNA; Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CHEK2 mRNA]

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

carbohydrate sulfotransferase 4

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CHST4 mRNA

NCBI chr19:54,900,914...54,911,735
Ensembl chr19:54,882,719...54,916,648

G

CBY1 interacting BAR domain containing 1

increases expression

ISO

kojic acid results in increased expression of CIBAR1 mRNA

NCBI chr 5:30,411,325...30,429,770
Ensembl chr 5:30,410,511...30,429,893

G

claudin 3

decreases expression

ISO

kojic acid results in decreased expression of CLDN3 mRNA

NCBI chr12:27,345,075...27,346,547
Ensembl chr12:27,345,076...27,348,841

G

claudin domain containing 2

decreases expression

ISO

kojic acid results in decreased expression of CLDND2 mRNA

NCBI chr 1:102,985,122...102,988,010
Ensembl chr 1:102,985,122...102,987,808

G

C-type lectin domain family 4, member B2

decreases expression

ISO

kojic acid results in decreased expression of CLEC4C mRNA

NCBI chr 4:158,148,434...158,171,933
Ensembl chr 4:158,148,314...158,172,249

G

CXADR-like membrane protein

decreases expression

ISO

kojic acid results in decreased expression of CLMP mRNA

NCBI chr 8:49,957,639...50,065,959
Ensembl chr 8:49,957,720...50,065,959

G

clusterin

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CLU mRNA

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

cornichon family member 1

increases expression

ISO

kojic acid results in increased expression of CNIH1 mRNA

NCBI chr15:22,517,755...22,529,651
Ensembl chr15:22,497,340...22,529,578

G

connector enhancer of kinase suppressor of Ras 2

decreases expression

ISO

kojic acid results in decreased expression of CNKSR2 mRNA

NCBI chr X:40,722,843...40,971,730
Ensembl chr X:40,722,996...40,965,604

G

collagen type XVII alpha 1 chain

decreases expression

ISO

kojic acid results in decreased expression of COL17A1 mRNA

NCBI chr 1:256,472,648...256,518,857
Ensembl chr 1:256,472,648...256,518,851

G

collagen type XXIV alpha 1 chain

decreases expression

ISO

kojic acid results in decreased expression of COL24A1 mRNA

NCBI chr 2:236,872,583...237,129,768
Ensembl chr 2:236,872,265...237,129,447

G

collagen like tail subunit of asymmetric acetylcholinesterase

increases expression

ISO

kojic acid results in increased expression of COLQ mRNA

NCBI chr16:6,738,251...6,830,492
Ensembl chr16:6,738,251...6,793,501

G

catechol-O-methyltransferase

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of COMT mRNA

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

COP9 signalosome subunit 2

decreases expression

ISO

kojic acid results in decreased expression of COPS2 mRNA

NCBI chr 3:133,537,729...133,563,493
Ensembl chr 3:133,537,732...133,563,369

G

coenzyme Q10A

increases expression

ISO

kojic acid results in increased expression of COQ10A mRNA

NCBI chr 7:1,376,591...1,387,694
Ensembl chr 7:1,376,591...1,382,722

G

coenzyme Q8A

increases expression

ISO

kojic acid results in increased expression of COQ8A mRNA

NCBI chr13:94,436,680...94,465,535
Ensembl chr13:94,436,546...94,463,378

G

carboxypeptidase B1

decreases expression

ISO

kojic acid results in decreased expression of CPB1 mRNA

NCBI chr 2:104,684,275...104,744,824
Ensembl chr 2:104,684,275...104,714,662

G

carboxypeptidase E

increases expression

ISO

kojic acid results in increased expression of CPE mRNA

NCBI chr16:29,796,707...29,908,647
Ensembl chr16:29,796,689...29,909,524

G

copine 5

increases expression

ISO

kojic acid results in increased expression of CPNE5 mRNA

NCBI chr20:7,208,389...7,290,959
Ensembl chr20:7,208,389...7,292,064

G

cAMP responsive element binding protein 1

decreases phosphorylation

ISO

kojic acid results in decreased phosphorylation of CREB1 protein

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

chromosome segregation 1 like

decreases expression

ISO

kojic acid results in decreased expression of CSE1L mRNA

NCBI chr 3:176,060,183...176,097,909
Ensembl chr 3:176,060,215...176,108,734

G

catenin alpha-like 1

decreases expression

ISO

kojic acid results in decreased expression of CTNNAL1 mRNA

NCBI chr 5:76,309,546...76,375,869
Ensembl chr 5:76,309,546...76,364,637

G

cathepsin Z

increases expression

ISO

kojic acid results in increased expression of CTSZ mRNA

NCBI chr 3:183,643,077...183,653,847
Ensembl chr 3:183,643,077...183,657,012

G

cytochrome b5 reductase 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYB5R3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYB5R3 mRNA

NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:116,186,729...116,204,306

G

cytochrome P450, family 26, subfamily b, polypeptide 1

increases expression

ISO

kojic acid results in increased expression of CYP26B1 mRNA

NCBI chr 4:118,599,356...118,616,176
Ensembl chr 4:118,599,356...118,616,176

G

cytochrome P450, family 2, subfamily b, polypeptide 15

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2B15 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP2B15 mRNA

NCBI chr 1:91,221,865...91,234,169
Ensembl chr 1:91,221,865...91,234,169

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP2B10 mRNA

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2C mRNA

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 2, subfamily c, polypeptide 13

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2C13 mRNA

NCBI chr 1:248,706,787...248,787,239
Ensembl chr 1:248,706,788...248,787,210

G

cytochrome P450, family 2, subfamily c, polypeptide 22

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2C70 mRNA

NCBI chr 1:248,941,143...248,980,767
Ensembl chr 1:248,904,062...248,971,182

G

cytochrome P450, family 2, subfamily c, polypeptide 7

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2C7 mRNA

NCBI chr 1:247,966,295...248,022,393
Ensembl chr 1:247,966,346...248,022,388

G

cytochrome P450, family 2, subfamily d, polypeptide 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2D13 mRNA

NCBI chr 7:115,797,785...115,802,142
Ensembl chr 7:115,797,789...115,802,158

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP2D22 mRNA

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 2, subfamily f, polypeptide 4

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2F2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP2F2 mRNA

NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:91,543,768...91,557,553

G

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4A22 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP4A22 mRNA

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231

G

cytochrome P450, family 4, subfamily b, polypeptide 1

multiple interactions

ISO
EXP

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CYP4B1 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNA

PMID:17917374 PMID:18544905

NCBI chr 5:134,375,807...134,413,635
Ensembl chr 5:134,375,807...134,393,116

G

cytochrome P450, family 4, subfamily f, polypeptide 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4F2 mRNA

NCBI chr 7:12,661,357...12,672,952
Ensembl chr 7:12,661,359...12,672,612

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytochrome P450 family 8 subfamily B member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP8B1 mRNA

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689

G

cytohesin 3

increases expression

ISO

kojic acid results in increased expression of CYTH3 mRNA

NCBI chr12:15,953,781...16,076,584
Ensembl chr12:15,953,791...16,047,506

G

cytohesin 1 interacting protein

increases expression

ISO

kojic acid results in increased expression of CYTIP mRNA

NCBI chr 3:63,106,895...63,183,769
Ensembl chr 3:63,107,607...63,134,832

G

diacylglycerol lipase, alpha

increases expression

ISO

kojic acid results in increased expression of DAGLA mRNA

NCBI chr 1:216,315,515...216,372,219
Ensembl chr 1:216,315,516...216,372,111

G

DAZ associated protein 2

increases expression

ISO

kojic acid results in increased expression of DAZAP2 mRNA

NCBI chr 7:133,593,503...133,599,044
Ensembl chr 7:133,593,512...133,599,047

G

DDB1 and CUL4 associated factor 13

decreases expression

ISO

kojic acid results in decreased expression of DCAF13 mRNA

NCBI chr 7:72,045,828...72,081,039
Ensembl chr 7:72,045,872...72,083,629

G

dopachrome tautomerase

decreases expression

ISO

kojic acid results in decreased expression of DCT protein

NCBI chr15:101,469,159...101,508,029
Ensembl chr15:101,469,159...101,508,029

G

DNA-damage inducible transcript 3

multiple interactions

EXP

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DEK proto-oncogene

decreases expression

ISO

kojic acid results in decreased expression of DEK mRNA

NCBI chr17:17,786,989...17,809,096
Ensembl chr17:17,787,139...17,810,122

G

DLG associated protein 4

increases expression

ISO

kojic acid results in increased expression of DLGAP4 mRNA

NCBI chr 3:165,584,271...165,731,868
Ensembl chr 3:165,584,360...165,730,604

G

distal-less homeobox 1

decreases expression

ISO

kojic acid results in decreased expression of DLX1 mRNA

NCBI chr 3:76,763,864...76,768,454
Ensembl chr 3:76,763,500...76,768,447

G

Dmx-like 1

decreases expression

ISO

kojic acid results in decreased expression of DMXL1 mRNA

NCBI chr18:45,179,505...45,349,999
Ensembl chr18:45,179,551...45,356,406

G

DnaJ heat shock protein family (Hsp40) member A1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of DNAJA1 mRNA

NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:60,638,410...60,650,160

G

DnaJ heat shock protein family (Hsp40) member A2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of DNAJA2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of DNAJA2 mRNA

NCBI chr19:37,671,019...37,689,163
Ensembl chr19:37,670,945...37,690,120

G

deoxynucleotidyltransferase, terminal, interacting protein 2

decreases expression

ISO

kojic acid results in decreased expression of DNTTIP2 mRNA

NCBI chr 2:213,058,975...213,071,020
Ensembl chr 2:213,058,962...213,071,016

G

dedicator of cytokinesis 4

increases expression

ISO

kojic acid results in increased expression of DOCK4 mRNA

NCBI chr 6:63,240,050...63,629,772
Ensembl chr 6:63,240,136...63,629,772

G

docking protein 4

decreases expression

ISO

kojic acid results in decreased expression of DOK4 mRNA

NCBI chr19:10,152,511...10,163,182
Ensembl chr19:10,152,458...10,164,190

G

dihydropyrimidine dehydrogenase

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of DPYD mRNA

NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:209,293,929...210,159,778

G

dentin sialophosphoprotein

decreases expression

ISO

kojic acid results in decreased expression of DSPP mRNA

NCBI chr14:5,870,232...5,876,339
Ensembl chr14:5,870,232...5,876,339

G

destrin, actin depolymerizing factor

increases expression

ISO

kojic acid results in increased expression of DSTN mRNA

NCBI chr 3:151,737,711...151,764,752
Ensembl chr 3:151,737,849...151,764,769

G

dynein light chain Tctex-type 3

decreases expression

ISO

kojic acid results in decreased expression of DYNLT3 mRNA

NCBI chr X:16,000,425...16,009,632
Ensembl chr X:16,000,395...16,009,627

G

E2F transcription factor 3

increases expression

ISO

kojic acid results in increased expression of E2F3 mRNA

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725

G

E2F transcription factor 8

increases expression

ISO

kojic acid results in increased expression of E2F8 mRNA

NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:107,701,985...107,720,009

G

ephrin A3

decreases expression

ISO

kojic acid results in decreased expression of EFNA3 mRNA

NCBI chr 2:177,026,928...177,035,838
Ensembl chr 2:177,026,933...177,044,843

G

early growth response 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

eukaryotic translation initiation factor 4E

decreases expression

ISO

kojic acid results in decreased expression of EIF4E mRNA

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

eukaryotic translation initiation factor 5A2

increases expression

ISO

kojic acid results in increased expression of EIF5A2 mRNA

NCBI chr 2:113,656,748...113,674,598
Ensembl chr 2:113,657,797...113,674,594

G

elastase, neutrophil expressed

decreases expression

ISO

kojic acid results in decreased expression of ELANE mRNA

NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:10,467,877...10,469,725

G

E1A binding protein p300

increases expression

ISO

kojic acid results in increased expression of EP300 mRNA

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

EPH receptor A10

decreases expression

ISO

kojic acid results in decreased expression of EPHA10 mRNA

NCBI chr 5:142,424,260...142,460,305
Ensembl chr 5:142,424,296...142,460,305

G

Eph receptor A4

increases expression

ISO

kojic acid results in increased expression of EPHA4 mRNA

NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755

G

epoxide hydrolase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of EPHX1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981

G

epoxide hydrolase 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of EPHX2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of EPHX2 mRNA

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160

G

ERCC excision repair 2, TFIIH core complex helicase subunit

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC2 mRNA

NCBI chr 1:88,161,342...88,175,102
Ensembl chr 1:88,160,988...88,175,102

G

ERCC excision repair 3, TFIIH core complex helicase subunit

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of ERCC3 mRNA

NCBI chr18:24,157,831...24,188,543
Ensembl chr18:24,148,084...24,190,898

G

ERCC excision repair 4, endonuclease catalytic subunit

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC4 mRNA

NCBI chr10:2,926,085...2,958,176
Ensembl chr10:2,920,455...2,955,539

G

ERCC excision repair 5, endonuclease

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC5 mRNA

NCBI chr 9:53,801,471...53,846,611
Ensembl chr 9:53,801,714...53,875,084

G

endothelial cell adhesion molecule

increases expression

ISO

kojic acid results in increased expression of ESAM mRNA

NCBI chr 8:45,426,985...45,437,976
Ensembl chr 8:45,425,731...45,437,973

G

epithelial splicing regulatory protein 1

increases expression

ISO

kojic acid results in increased expression of ESRP1 mRNA

NCBI chr 5:29,224,831...29,279,381
Ensembl chr 5:29,225,360...29,279,278

G

exonuclease 3'-5' domain containing 1

decreases expression

ISO

kojic acid results in decreased expression of EXD1 mRNA

NCBI chr 3:126,961,800...126,989,738
Ensembl chr 3:126,961,896...126,989,738

G

exocyst complex component 2

increases expression

ISO

kojic acid results in increased expression of EXOC2 mRNA

NCBI chr17:33,714,949...33,906,901
Ensembl chr17:33,715,008...33,901,944

G

coagulation factor X

increases expression

ISO

kojic acid results in increased expression of F10 mRNA

NCBI chr16:83,170,973...83,190,280
Ensembl chr16:83,170,977...83,190,280

G

family with sequence similarity 241 member A

increases expression

ISO

kojic acid results in increased expression of FAM241A mRNA

NCBI chr 2:219,019,025...219,049,648
Ensembl chr 2:219,018,241...219,049,770

G

fibrillin 2

increases expression

ISO

kojic acid results in increased expression of FBN2 mRNA

NCBI chr18:53,696,197...53,901,992
Ensembl chr18:53,697,708...53,902,191

G

F-box protein 16

increases expression

ISO

kojic acid results in increased expression of FBXO16 mRNA

NCBI chr15:43,667,207...43,717,096
Ensembl chr15:43,667,855...43,734,346

G

FERRY endosomal RAB5 effector complex subunit 3

decreases expression

ISO

kojic acid results in decreased expression of FERRY3 mRNA

NCBI chr 4:161,458,942...161,494,213
Ensembl chr 4:161,458,931...161,493,075

G

fibroblast growth factor 12

increases expression

ISO

kojic acid results in increased expression of FGF12 mRNA

NCBI chr11:85,501,947...86,069,543
Ensembl chr11:85,501,936...86,069,543

G

fibroblast growth factor 5

decreases expression

ISO

kojic acid results in decreased expression of FGF5 mRNA

NCBI chr14:11,627,906...11,650,243
Ensembl chr14:11,627,906...11,650,243

G

fibroblast growth factor receptor 3

decreases expression

ISO

kojic acid results in decreased expression of FGFR3 mRNA

NCBI chr14:81,211,800...81,227,215
Ensembl chr14:81,211,800...81,227,209

G

fibrinogen C domain containing 1

decreases expression

ISO

kojic acid results in decreased expression of FIBCD1 mRNA

NCBI chr 3:35,490,459...35,524,142
Ensembl chr 3:35,490,459...35,524,142

G

FKBP prolyl isomerase 10

increases expression

ISO

kojic acid results in increased expression of FKBP10 mRNA

NCBI chr10:85,845,801...85,858,361
Ensembl chr10:85,844,703...85,858,355

G

flavin containing dimethylaniline monoxygenase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of FMO1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of FMO1 mRNA

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

fucose-1-phosphate guanylyltransferase

decreases expression

ISO

kojic acid results in decreased expression of FPGT mRNA

NCBI chr 2:246,757,982...246,778,896
Ensembl chr 2:246,757,986...246,778,848

G

FERM and PDZ domain containing 4

decreases expression

ISO

kojic acid results in decreased expression of FRMPD4 mRNA

NCBI chr X:29,739,834...30,386,917
Ensembl chr X:29,368,849...30,384,621

G

40S small subunit processome assembly factor 1

decreases expression

ISO

kojic acid results in decreased expression of FSAF1 mRNA

NCBI chr19:69,705,313...69,719,894
Ensembl chr19:69,705,321...69,720,093

G

ferritin heavy chain 1

increases expression

ISO

kojic acid results in increased expression of FTH1 mRNA; kojic acid results in increased expression of FTH1 protein

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

frizzled class receptor 8

increases expression

ISO

kojic acid results in increased expression of FZD8 mRNA

NCBI chr17:62,007,849...62,015,485
Ensembl chr17:62,007,627...62,015,961

G

growth arrest and DNA-damage-inducible, beta

multiple interactions

EXP

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

polypeptide N-acetylgalactosaminyltransferase 1

decreases expression

ISO

kojic acid results in decreased expression of GALNT1 mRNA

NCBI chr18:15,763,697...15,843,598
Ensembl chr18:15,764,277...15,843,588

G

Gfo/Idh/MocA-like oxidoreductase domain containing 1

decreases expression

ISO

kojic acid results in decreased expression of GFOD1 mRNA

NCBI chr17:21,606,090...21,710,922
Ensembl chr17:21,605,415...21,710,920

G

GLE1 RNA export mediator

decreases expression

ISO

kojic acid results in decreased expression of GLE1 mRNA

NCBI chr 3:33,607,160...33,638,879

G

guanosine monophosphate reductase

decreases expression

ISO

kojic acid results in decreased expression of GMPR mRNA

NCBI chr17:19,357,992...19,395,807
Ensembl chr17:19,357,992...19,431,655

G

G protein subunit beta 1

increases expression

ISO

kojic acid results in increased expression of GNB1 mRNA

NCBI chr 5:171,357,778...171,424,489
Ensembl chr 5:171,357,797...171,424,488

G

G protein-coupled receptor 146

decreases expression

ISO

kojic acid results in decreased expression of GPR146 mRNA

NCBI chr12:20,365,790...20,381,122
Ensembl chr12:20,364,269...20,381,345

G

G protein-coupled receptor 26

decreases expression

ISO

kojic acid results in decreased expression of GPR26 mRNA

NCBI chr 1:196,196,138...196,235,574
Ensembl chr 1:196,196,767...196,235,559

G

G protein-coupled receptor 32

increases expression

ISO

kojic acid results in increased expression of GPR32 mRNA

NCBI chr 1:103,893,405...103,894,667

G

G protein-coupled receptor 61

decreases expression

ISO

kojic acid results in decreased expression of GPR61 mRNA

NCBI chr 2:198,471,430...198,477,827
Ensembl chr 2:198,427,135...198,477,874

G

glutathione peroxidase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GPX1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

gasdermin A

decreases expression

ISO

kojic acid results in decreased expression of GSDMA mRNA

NCBI chr10:84,110,590...84,135,804
Ensembl chr10:84,123,314...84,135,804

G

glutathione-disulfide reductase

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTA2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTA2 mRNA

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092

G

glutathione S-transferase alpha 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTA3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTA3 mRNA

NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654

G

glutathione S-transferase alpha 4

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTA4 mRNA

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488

G

glutathione S-transferase mu 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM1 mRNA

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase mu 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase, mu 5

multiple interactions

ISO
EXP

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM3 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM3 mRNA

PMID:17917374 PMID:18544905

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731

G

guanylate cyclase 1 soluble subunit alpha 2

decreases expression

ISO

kojic acid results in decreased expression of GUCY1A2 mRNA

NCBI chr 8:8,785,212...9,174,322
Ensembl chr 8:8,785,121...9,174,272

G

H1.1 linker histone, cluster member

increases expression

ISO

kojic acid results in increased expression of H1-1 mRNA

NCBI chr17:41,762,278...41,794,876

G

H2A clustered histone 6

increases expression

ISO

kojic acid results in increased expression of H2AC6 mRNA

NCBI chr17:47,403,701...47,404,167

G

heart and neural crest derivatives expressed 1

increases expression

ISO

kojic acid results in increased expression of HAND1 mRNA

NCBI chr10:42,507,117...42,509,684
Ensembl chr10:42,507,122...42,509,684

G

harbinger transposase derived 1

decreases expression

ISO

kojic acid results in decreased expression of HARBI1 mRNA

NCBI chr 3:98,137,087...98,145,992
Ensembl chr 3:98,137,123...98,146,315

G

3-hydroxyisobutyryl-CoA hydrolase

decreases expression

ISO

kojic acid results in decreased expression of HIBCH mRNA

NCBI chr 9:56,082,082...56,161,796
Ensembl chr 9:56,082,091...56,161,886

G

histidine triad nucleotide binding protein 3

increases expression

ISO

kojic acid results in increased expression of HINT3 mRNA

NCBI chr 1:28,854,860...28,864,723
Ensembl chr 1:28,854,844...28,867,125

G

huntingtin interacting protein 1

increases expression

ISO

kojic acid results in increased expression of HIP1 mRNA

NCBI chr12:26,769,868...26,904,367
Ensembl chr12:26,769,961...26,904,296

G

HLF transcription factor, PAR bZIP family member

decreases expression

ISO

kojic acid results in decreased expression of HLF mRNA

NCBI chr10:75,651,320...75,708,979
Ensembl chr10:75,654,534...75,708,619

G

hyaluronan-mediated motility receptor

decreases expression

ISO

kojic acid results in decreased expression of HMMR mRNA

NCBI chr10:25,635,249...25,665,389
Ensembl chr10:25,635,915...25,665,390

G

heme oxygenase 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HMOX2 mRNA

NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800

G

heterogeneous nuclear ribonucleoprotein H2

increases expression

ISO

kojic acid results in increased expression of HNRNPH2 mRNA

NCBI chr X:102,074,175...102,080,115
Ensembl chr X:102,074,179...102,081,025

G

HPS3, biogenesis of lysosomal organelles complex 2 subunit 1

decreases expression

ISO

kojic acid results in decreased expression of HPS3 mRNA

NCBI chr 2:104,413,618...104,455,091
Ensembl chr 2:104,413,417...104,455,091

G

heat shock protein 90 alpha family class A member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSP90AA1 mRNA

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein 90 alpha family class B member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSP90AB1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPA1A mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 5

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family B (small) member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPB1 mRNA

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family D (Hsp60) member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPD1 mRNA

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

heat shock protein family E (Hsp10) member 1

multiple interactions

EXP
ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPE1 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of HSPE1 mRNA

PMID:17917374 PMID:18544905

NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:64,085,068...64,087,502

G

hypoxia up-regulated 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HYOU1 mRNA

NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:53,602,604...53,614,997

G

insulin-like growth factor 2 receptor

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of IGF2R mRNA

NCBI chr 1:50,526,878...50,615,265
Ensembl chr 1:50,526,878...50,615,265

G

interleukin 1 alpha

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor-like 1

increases expression

ISO

kojic acid results in increased expression of IL1RL1 mRNA

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891

G

interleukin 22 receptor subunit alpha 1

increases expression

ISO

kojic acid results in increased expression of IL22RA1 mRNA

NCBI chr 5:153,245,067...153,269,865
Ensembl chr 5:153,245,002...153,271,683

G

interleukin 6

decreases expression

ISO

kojic acid results in decreased expression of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 cytokine family signal transducer

decreases expression

ISO

kojic acid results in decreased expression of IL6ST mRNA

NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182

G

inner centromere protein

increases expression

ISO

kojic acid results in increased expression of INCENP mRNA

NCBI chr 1:215,945,558...216,017,247
Ensembl chr 1:215,948,283...215,977,084

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

kojic acid results in increased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

lysyl-tRNA synthetase 1

decreases expression

ISO

kojic acid results in decreased expression of KARS1 mRNA

NCBI chr19:56,867,096...56,886,151
Ensembl chr19:56,867,096...56,886,073

G

potassium voltage-gated channel subfamily A regulatory beta subunit 3

decreases expression

ISO

kojic acid results in decreased expression of KCNAB3 mRNA

NCBI chr10:54,546,638...54,555,209
Ensembl chr10:54,546,618...54,553,357

G

potassium channel tetramerization domain containing 17

decreases expression

ISO

kojic acid results in decreased expression of KCTD17 mRNA

NCBI chr 7:111,859,556...111,891,869
Ensembl chr 7:111,859,256...111,870,692

G

lysine demethylase 4D

increases expression

ISO

kojic acid results in increased expression of KDM4D mRNA

NCBI chr 8:19,561,253...19,586,412
Ensembl chr 8:19,548,676...19,587,331

G

KLF transcription factor 5

increases expression

ISO

kojic acid results in increased expression of KLF5 mRNA

NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262

G

kelch-like family member 13

increases expression

ISO

kojic acid results in increased expression of KLHL13 mRNA

NCBI chr X:118,747,298...118,912,279
Ensembl chr X:118,747,298...118,855,035

G

kallikrein B1

decreases expression

ISO

kojic acid results in decreased expression of KLKB1 mRNA

NCBI chr16:53,690,180...53,714,570
Ensembl chr16:53,691,220...53,716,339

G

keratin 7

increases expression

ISO

kojic acid results in increased expression of KRT7 mRNA

NCBI chr 7:134,407,626...134,423,787
Ensembl chr 7:134,407,584...134,423,786

G

kinectin 1

decreases expression

ISO

kojic acid results in decreased expression of KTN1 mRNA

NCBI chr15:23,392,570...23,485,061
Ensembl chr15:23,394,315...23,482,263

G

La ribonucleoprotein 7, transcriptional regulator

decreases expression

ISO

kojic acid results in decreased expression of LARP7 mRNA

NCBI chr 2:218,672,145...218,687,332
Ensembl chr 2:218,672,208...218,687,308

G

leukocyte immunoglobulin like receptor B3

decreases expression

ISO

kojic acid results in decreased expression of LILRB5 mRNA

NCBI chr 1:79,001,483...79,011,054
Ensembl chr 1:79,001,600...79,010,981

G

LDL receptor related protein 6

decreases expression

ISO

kojic acid results in decreased expression of LRP6 mRNA

NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:169,000,968...169,131,716

G

leucine rich repeat containing 4

decreases expression

ISO

kojic acid results in decreased expression of LRRC4 mRNA

NCBI chr 4:58,398,942...58,402,538
Ensembl chr 4:58,397,302...58,402,808

G

leucine rich repeat containing 9

increases expression

ISO

kojic acid results in increased expression of LRRC9 mRNA

NCBI chr 6:96,746,972...96,831,840
Ensembl chr 6:96,761,246...96,845,259

G

macrophage erythroblast attacher, E3 ubiquitin ligase

increases expression

ISO

kojic acid results in increased expression of MAEA mRNA

NCBI chr14:81,581,784...81,615,246
Ensembl chr14:81,581,785...81,615,202

G

MAF bZIP transcription factor K

decreases expression

ISO

kojic acid results in decreased expression of MAFK mRNA

NCBI chr12:19,948,473...19,970,351
Ensembl chr12:19,948,476...19,959,192

G

MAGE family member C2

increases expression

ISO

kojic acid results in increased expression of MAGEC2 mRNA

NCBI chr X:145,646,856...145,651,730
Ensembl chr X:145,646,830...145,651,721

G

monoamine oxidase A

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOA mRNA

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MAOB mRNA

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

MAP7 domain containing 2

decreases expression

ISO

kojic acid results in decreased expression of MAP7D2 mRNA

NCBI chr X:39,181,091...39,296,814
Ensembl chr X:39,181,091...39,296,695

G

mitogen activated protein kinase 1

decreases phosphorylation

ISO

kojic acid results in decreased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

decreases phosphorylation

ISO

kojic acid results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

decreases expression

ISO

kojic acid results in decreased expression of MAPK8 mRNA

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

muscleblind-like splicing regulator 1

decreases expression

ISO

kojic acid results in decreased expression of MBNL1 mRNA

NCBI chr 2:146,789,570...146,964,136
Ensembl chr 2:146,789,596...146,964,134

G

melanocortin 1 receptor

decreases expression
increases expression

ISO

kojic acid results in decreased expression of MC1R protein
kojic acid results in increased expression of MC1R protein

PMID:23738040 PMID:27586645

NCBI chr19:68,360,950...68,363,877
Ensembl chr19:68,360,950...68,363,877

G

MyoD family inhibitor

decreases expression

ISO

kojic acid results in decreased expression of MDFI mRNA

NCBI chr 9:20,654,359...20,672,768
Ensembl chr 9:20,654,417...20,672,767

G

MDM2 proto-oncogene

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

malic enzyme 3

decreases expression

ISO

kojic acid results in decreased expression of ME3 mRNA

NCBI chr 1:152,946,595...153,148,026
Ensembl chr 1:152,946,628...153,148,026

G

mediator complex subunit 14

increases expression

ISO

kojic acid results in increased expression of MED14 mRNA

NCBI chr X:12,709,406...12,800,642
Ensembl chr X:12,709,472...12,800,640

G

mex-3 RNA binding family member B

increases expression

ISO

kojic acid results in increased expression of MEX3B mRNA

NCBI chr 1:146,264,319...146,268,554
Ensembl chr 1:146,264,318...146,268,543

G

microfibril associated protein 4

decreases expression

ISO

kojic acid results in decreased expression of MFAP4 mRNA

NCBI chr10:46,666,552...46,669,613
Ensembl chr10:46,655,722...46,669,740

G

O-6-methylguanine-DNA methyltransferase

multiple interactions

EXP

[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA; Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA]

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

microsomal glutathione S-transferase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MGST1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MGST1 mRNA

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

midnolin

decreases expression

ISO

kojic acid results in decreased expression of MIDN mRNA

NCBI chr 7:10,198,761...10,210,563
Ensembl chr 7:10,200,306...10,207,203

G

macrophage migration inhibitory factor

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MIF mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MIF mRNA

NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121

G

meiotic nuclear divisions 1

increases expression

ISO

kojic acid results in increased expression of GAJ mRNA

NCBI chr 2:171,731,523...171,794,124
Ensembl chr 2:171,731,523...171,794,095

G

mitochondrial ribosomal protein L30

decreases expression

ISO

kojic acid results in decreased expression of MRPL30 mRNA

NCBI chr 9:47,621,226...47,631,986
Ensembl chr 9:47,621,227...47,633,484

G

mitochondrially encoded cytochrome c oxidase I

increases expression

ISO

kojic acid results in increased expression of COX1 mRNA; kojic acid results in increased expression of COX1 protein

NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853

G

Mtr4 exosome RNA helicase

decreases expression

ISO

kojic acid results in decreased expression of MTREX mRNA

NCBI chr 2:46,233,528...46,293,827
Ensembl chr 2:46,194,647...46,293,827

G

major vault protein

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MVP mRNA

NCBI chr 1:191,025,259...191,052,866
Ensembl chr 1:191,025,268...191,052,873

G

N(alpha)-acetyltransferase 25, NatB auxiliary subunit

increases expression

ISO

kojic acid results in increased expression of NAA25 mRNA

NCBI chr12:40,758,909...40,811,192
Ensembl chr12:40,758,728...40,811,291

G

neurocalcin delta

decreases expression

ISO

kojic acid results in decreased expression of NCALD mRNA

NCBI chr 7:70,417,683...70,849,763
Ensembl chr 7:70,419,433...70,849,482

G

NADH:ubiquinone oxidoreductase subunit A1

increases expression

ISO

kojic acid results in increased expression of NDUFA1 mRNA

NCBI chr X:121,289,904...121,293,555
Ensembl chr X:121,289,925...121,293,555

G

nectin cell adhesion molecule 4

increases expression

ISO

kojic acid results in increased expression of NECTIN4 mRNA

NCBI chr13:86,335,027...86,354,152
Ensembl chr13:86,335,831...86,353,967

G

nuclear factor, interleukin 3 regulated

increases expression

ISO

kojic acid results in increased expression of NFIL3 mRNA

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826

G

NFKB inhibitor alpha

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of NFKBIA mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of NFKBIA mRNA

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor epsilon

increases expression

ISO

kojic acid results in increased expression of NFKBIE mRNA

NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:22,941,040...22,947,872

G

NK6 homeobox 1

decreases expression

ISO

kojic acid results in decreased expression of NKX6-1 mRNA

NCBI chr14:8,274,238...8,281,171
Ensembl chr14:8,274,238...8,281,163

G

neuroligin 2

decreases expression

ISO

kojic acid results in decreased expression of NLGN2 mRNA

NCBI chr10:55,042,175...55,056,578
Ensembl chr10:55,043,185...55,056,578

G

NOC3-like DNA replication regulator

decreases expression

ISO

kojic acid results in decreased expression of NOC3L mRNA

NCBI chr 1:245,969,179...245,997,761
Ensembl chr 1:245,969,179...245,997,708

G

nucleolar protein 11

decreases expression

ISO

kojic acid results in decreased expression of NOL11 mRNA

NCBI chr10:92,621,482...92,641,394
Ensembl chr10:92,621,498...92,641,394

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of NR1I2 mRNA

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of NR1I3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of NR1I3 mRNA

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

outer dynein arm docking complex subunit 2

increases expression

ISO

kojic acid results in increased expression of ODAD2 mRNA

NCBI chr17:59,910,665...60,104,929
Ensembl chr17:59,910,757...60,103,547

G

olfactomedin-like 1

decreases expression

ISO

kojic acid results in decreased expression of OLFML1 mRNA

NCBI chr 1:170,889,912...170,914,300
Ensembl chr 1:170,889,980...170,915,762

G

olfactory receptor family 51 subfamily B member 4

decreases expression

ISO

kojic acid results in decreased expression of OR51B4 mRNA

NCBI chr 1:167,729,117...167,730,040
Ensembl chr 1:167,729,117...167,730,040

G

oxysterol binding protein 2

decreases expression

ISO

kojic acid results in decreased expression of OSBP2 mRNA

NCBI chr14:82,808,693...82,970,386
Ensembl chr14:82,808,693...82,970,532

G

osteoclastogenesis associated transmembrane protein 1

decreases expression

ISO

kojic acid results in decreased expression of OSTM1 mRNA

NCBI chr20:47,653,696...47,769,248
Ensembl chr20:47,653,670...47,769,237

G

orthodenticle homeobox 1

increases expression

ISO

kojic acid results in increased expression of OTX1 mRNA

NCBI chr14:100,283,406...100,290,421
Ensembl chr14:100,283,406...100,290,421

G

PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1

increases expression

ISO

kojic acid results in increased expression of PABIR1 mRNA

NCBI chr 1:231,541,411...231,542,717
Ensembl chr 1:231,537,357...231,612,411

G

Paxip1-associated glutamate-rich protein 1

increases expression

ISO

kojic acid results in increased expression of PAGR1 mRNA

NCBI chr 1:191,053,228...191,055,554

G

phenylalanine hydroxylase

decreases expression

ISO

kojic acid results in decreased expression of PAH mRNA

NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:23,792,781...23,885,627

G

poly (ADP-ribose) glycohydrolase

increases expression

ISO

kojic acid results in increased expression of PARG mRNA

NCBI chr16:7,442,696...7,550,585
Ensembl chr16:7,442,726...7,550,584

G

PDZ binding kinase

decreases expression

ISO

kojic acid results in decreased expression of PBK mRNA

NCBI chr15:44,198,506...44,209,572
Ensembl chr15:44,198,544...44,209,570

G

proliferating cell nuclear antigen

multiple interactions

ISO
EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of PCNA protein
[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in increased expression of PCNA protein

PMID:17917374 PMID:18544905

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

pecanex 3

decreases expression

ISO

kojic acid results in decreased expression of PCNX3 mRNA

NCBI chr 1:212,380,657...212,402,967
Ensembl chr 1:212,379,851...212,403,166

G

proprotein convertase subtilisin/kexin type 4

decreases expression

ISO

kojic acid results in decreased expression of PCSK4 mRNA

NCBI chr 7:10,032,040...10,040,263
Ensembl chr 7:10,031,988...10,040,255

G

phosducin like

increases expression

ISO

kojic acid results in increased expression of PDCL mRNA

NCBI chr 3:41,519,953...41,529,545
Ensembl chr 3:41,519,954...41,527,794
Ensembl chr 3:41,519,954...41,527,794

G

pyruvate dehydrogenase E1 subunit alpha 1

increases expression

ISO

kojic acid results in increased expression of PDHA1 mRNA

NCBI chr X:38,509,158...38,522,986
Ensembl chr X:38,509,084...38,522,536

G

protein disulfide isomerase family A, member 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PDIA3 mRNA

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

PDZ and LIM domain 2

increases expression

ISO

kojic acid results in increased expression of PDLIM2 mRNA

NCBI chr15:51,647,195...51,659,904
Ensembl chr15:51,647,197...51,658,958

G

PPARGC1 and ESRR induced regulator, muscle 1

decreases expression

ISO

kojic acid results in decreased expression of PERM1 mRNA

NCBI chr 5:172,082,249...172,087,542
Ensembl chr 5:172,082,249...172,087,542

G

peroxisomal biogenesis factor 5-like

decreases expression

ISO

kojic acid results in decreased expression of PEX5L mRNA

NCBI chr 2:117,623,199...117,836,772
Ensembl chr 2:117,623,199...117,836,685

G

phosphoglucomutase 2

increases expression

ISO

kojic acid results in increased expression of PGM2 mRNA

NCBI chr14:44,519,906...44,553,420
Ensembl chr14:44,519,906...44,553,770

G

phosphatidylinositol glycan anchor biosynthesis, class Q

decreases expression

ISO

kojic acid results in decreased expression of PIGQ mRNA

NCBI chr10:15,447,080...15,463,088
Ensembl chr10:15,447,081...15,463,088

G

phosphatidylinositol transfer protein, beta

increases expression

ISO

kojic acid results in increased expression of PITPNB mRNA

NCBI chr12:50,909,140...50,958,193
Ensembl chr12:50,909,143...50,958,140

G

PLAG1 like zinc finger 1

increases expression

ISO

kojic acid results in increased expression of PLAGL1 mRNA

NCBI chr 1:9,297,066...9,337,394
Ensembl chr 1:9,330,204...9,337,394

G

protein O-glucosyltransferase 2

increases expression

ISO

kojic acid results in increased expression of POGLUT2 mRNA

NCBI chr 9:53,748,484...53,801,453
Ensembl chr 9:53,740,998...53,760,588

G

paraoxonase 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PON3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of PON3 mRNA

NCBI chr 4:34,323,546...34,350,244
Ensembl chr 4:34,315,889...34,350,244

G

cytochrome p450 oxidoreductase

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of POR mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of POR mRNA

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

POU class 2 homeobox 3

decreases expression

ISO

kojic acid results in decreased expression of POU2F3 mRNA

NCBI chr 8:52,392,363...52,474,756
Ensembl chr 8:52,392,497...52,474,756

G

protein phosphatase 4, regulatory subunit 1

increases expression

ISO

kojic acid results in increased expression of PPP4R1 mRNA

NCBI chr 9:112,836,950...112,897,490
Ensembl chr 9:112,838,812...112,897,557

G

peroxiredoxin 1

multiple interactions

EXP

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PRDX1 mRNA

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

peroxiredoxin 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PRDX2 mRNA

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

proteoglycan 2, pro eosinophil major basic protein

decreases expression

ISO

kojic acid results in decreased expression of PRG2 mRNA

NCBI chr 3:90,469,192...90,472,759
Ensembl chr 3:90,469,176...90,472,752

G

prickle planar cell polarity protein 3

decreases expression

ISO

kojic acid results in decreased expression of PRICKLE3 mRNA

NCBI chr X:17,509,551...17,520,157
Ensembl chr X:17,509,554...17,520,122

G

DNA primase subunit 1

decreases expression

ISO

kojic acid results in decreased expression of PRIM1 mRNA

NCBI chr 7:1,031,436...1,047,134

G

protein arginine methyltransferase 2

decreases expression

ISO

kojic acid results in decreased expression of PRMT2 mRNA

NCBI chr20:12,391,388...12,420,096
Ensembl chr20:12,394,268...12,420,108

G

pre-mRNA processing factor 40 homolog A

decreases expression

ISO

kojic acid results in decreased expression of PRPF40A mRNA

NCBI chr 3:58,036,779...58,098,996
Ensembl chr 3:58,038,042...58,099,363

G

phosphoribosyl pyrophosphate synthetase 2

increases expression

ISO

kojic acid results in increased expression of PRPS2 mRNA

NCBI chr X:30,592,845...30,630,127
Ensembl chr X:30,593,019...30,630,126

G

proline rich 18

decreases expression

ISO

kojic acid results in decreased expression of PRR18 mRNA

NCBI chr 1:54,947,775...54,951,558
Ensembl chr 1:54,947,351...54,959,997

G

proline-rich coiled-coil 2C

increases expression

ISO

kojic acid results in increased expression of PRRC2C mRNA

NCBI chr13:77,537,226...77,606,926
Ensembl chr13:77,537,814...77,607,001

G

paired related homeobox 1

decreases expression

ISO

kojic acid results in decreased expression of PRRX1 mRNA

NCBI chr13:78,136,783...78,205,379
Ensembl chr13:78,136,783...78,204,058

G

proteasome 26S subunit, ATPase 6

decreases expression

ISO

kojic acid results in decreased expression of PSMC6 mRNA

NCBI chr15:21,022,314...21,043,785
Ensembl chr15:21,022,314...21,043,785

G

proteasome 26S subunit, non-ATPase 3

decreases expression

ISO

kojic acid results in decreased expression of PSMD3 mRNA

NCBI chr10:84,139,249...84,151,879
Ensembl chr10:84,139,677...84,151,878

G

pseudouridine synthase 7 like

decreases expression

ISO

kojic acid results in decreased expression of PUS7L mRNA

NCBI chr 7:127,538,785...127,561,936
Ensembl chr 7:127,538,558...127,561,798

G

RAB3 GTPase activating protein catalytic subunit 1

increases expression

ISO

kojic acid results in increased expression of RAB3GAP1 mRNA

NCBI chr13:41,908,179...41,981,611
Ensembl chr13:41,908,051...41,981,611

G

RAB6B, member RAS oncogene family

decreases expression

ISO

kojic acid results in decreased expression of RAB6B mRNA

NCBI chr 8:112,574,223...112,642,911
Ensembl chr 8:112,574,167...112,642,907

G

RAD1 checkpoint DNA exonuclease

increases expression

ISO

kojic acid results in increased expression of RAD1 mRNA

NCBI chr 2:61,188,755...61,196,868
Ensembl chr 2:61,188,727...61,196,867

G

RAD23 homolog A, nucleotide excision repair protein

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RAD23A mRNA

NCBI chr19:40,219,235...40,225,543
Ensembl chr19:40,219,636...40,225,543

G

RAD50 double strand break repair protein

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of RAD50 mRNA

NCBI chr10:38,310,147...38,362,100
Ensembl chr10:38,310,147...38,362,100

G

retinoic acid receptor, alpha

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RARA mRNA

NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160

G

retinoic acid receptor, beta

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RARB mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of RARB mRNA

NCBI chr15:10,837,252...11,482,037
Ensembl chr15:11,131,358...11,482,040

G

ras related dexamethasone induced 1

increases expression

ISO

kojic acid results in increased expression of RASD1 mRNA

NCBI chr10:45,265,975...45,275,279
Ensembl chr10:45,265,979...45,267,710

G

RasGEF domain family, member 1B

decreases expression

ISO

kojic acid results in decreased expression of RASGEF1B mRNA

NCBI chr14:10,164,366...10,684,184
Ensembl chr14:10,644,521...10,697,296

G

Ras association domain family member 3

increases expression

ISO

kojic acid results in increased expression of RASSF3 mRNA

NCBI chr 7:58,821,360...58,886,020
Ensembl chr 7:58,821,360...58,886,020

G

RB1-inducible coiled-coil 1

decreases expression

ISO

kojic acid results in decreased expression of RB1CC1 mRNA

NCBI chr 5:17,948,522...18,012,434
Ensembl chr 5:17,948,522...18,012,434

G

RNA binding motif protein 38

decreases expression

ISO

kojic acid results in decreased expression of RBM38 mRNA

NCBI chr 3:182,219,898...182,232,723
Ensembl chr 3:182,219,899...182,232,714

G

RecQ like helicase

decreases expression

ISO

kojic acid results in decreased expression of RECQL mRNA

NCBI chr 4:177,039,351...177,063,968
Ensembl chr 4:177,035,128...177,063,838

G

regulating synaptic membrane exocytosis 2

decreases expression

ISO

kojic acid results in decreased expression of RIMS2 mRNA

NCBI chr 7:72,133,004...72,644,059
Ensembl chr 7:72,133,170...72,645,499

G

round spermatid basic protein 1

decreases expression

ISO

kojic acid results in decreased expression of RSBN1 mRNA

NCBI chr 2:194,105,058...194,159,142
Ensembl chr 2:194,105,061...194,159,142

G

serum amyloid A4

decreases expression

ISO

kojic acid results in decreased expression of SAA4 mRNA

NCBI chr 1:106,383,856...106,388,158
Ensembl chr 1:106,383,856...106,387,354

G

scavenger receptor class B, member 1

increases expression

ISO

kojic acid results in increased expression of SCARB1 mRNA

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

sodium voltage-gated channel alpha subunit 10

decreases expression

ISO

kojic acid results in decreased expression of SCN10A mRNA

NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:128,228,424...128,340,298

G

sterol carrier protein 2

decreases expression

ISO

kojic acid results in decreased expression of SCP2 mRNA

NCBI chr 5:128,035,714...128,110,015
Ensembl chr 5:128,008,125...128,110,043

G

syndecan 4

decreases expression

ISO

kojic acid results in decreased expression of SDC4 mRNA

NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:173,574,239...173,593,670

G

SEC24 homolog B, COPII coat complex component

increases expression

ISO

kojic acid results in increased expression of SEC24B mRNA

NCBI chr 2:221,236,897...221,306,986
Ensembl chr 2:221,236,898...221,306,919

G

SEC62 homolog, preprotein translocation factor

decreases expression

ISO

kojic acid results in decreased expression of SEC62 mRNA

NCBI chr 2:114,499,317...114,526,705
Ensembl chr 2:114,499,317...114,530,321

G

secreted and transmembrane 1B

decreases expression

ISO

kojic acid results in decreased expression of SECTM1 mRNA

NCBI chr10:106,822,397...106,832,105
Ensembl chr10:106,822,397...106,832,104

G

septin 7

decreases expression

ISO

kojic acid results in decreased expression of SEPTIN7 mRNA

NCBI chr 8:31,995,597...32,059,069
Ensembl chr 8:31,995,005...32,059,072

G

serpin family A member 5

decreases expression

ISO

kojic acid results in decreased expression of SERPINA5 mRNA

NCBI chr 6:128,774,006...128,793,187
Ensembl chr 6:128,784,991...128,793,186

G

SHC binding and spindle associated 1

increases expression

ISO

kojic acid results in increased expression of SHCBP1 mRNA

NCBI chr16:91,373,843...91,405,409
Ensembl chr16:91,373,871...91,405,409

G

SIN3 transcription regulator family member B

decreases expression

ISO

kojic acid results in decreased expression of SIN3B mRNA

NCBI chr16:17,157,352...17,194,051
Ensembl chr16:17,157,352...17,270,664

G

solute carrier family 17, member 2

decreases expression

ISO

kojic acid results in decreased expression of SLC17A2 mRNA

NCBI chr17:41,748,195...41,767,601
Ensembl chr17:41,748,195...41,764,180

G

solute carrier family 25 member 2

decreases expression

ISO

kojic acid results in decreased expression of SLC25A2 mRNA

NCBI chr18:29,704,182...29,707,563
Ensembl chr18:29,703,871...29,708,827

G

solute carrier family 38, member 4

decreases expression

ISO

kojic acid results in decreased expression of SLC38A4 mRNA

NCBI chr 7:130,022,039...130,082,169
Ensembl chr 7:130,023,980...130,082,097

G

structural maintenance of chromosomes 6

decreases expression

ISO

kojic acid results in decreased expression of SMC6 mRNA

NCBI chr 6:39,697,810...39,752,275
Ensembl chr 6:39,697,811...39,752,279

G

small integral membrane protein 8

decreases expression

ISO

kojic acid results in decreased expression of SMIM8 mRNA

NCBI chr 5:54,132,905...54,141,940
Ensembl chr 5:54,132,905...54,141,729

G

sorting nexin 10

decreases expression

ISO

kojic acid results in decreased expression of SNX10 mRNA

NCBI chr 4:81,943,262...82,007,667
Ensembl chr 4:81,943,287...82,007,651

G

sterol O-acyltransferase 2

increases expression

ISO

kojic acid results in increased expression of SOAT2 mRNA

NCBI chr 7:135,160,424...135,173,521
Ensembl chr 7:135,160,402...135,173,513

G

superoxide dismutase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

spermatogenesis associated 25

decreases expression

ISO

kojic acid results in decreased expression of SPATA25 mRNA

NCBI chr 3:173,981,863...173,983,818
Ensembl chr 3:173,981,866...173,983,818

G

secreted phosphoprotein 1

increases expression

ISO

kojic acid results in increased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

serine palmitoyltransferase, long chain base subunit 1

increases expression

ISO

kojic acid results in increased expression of SPTLC1 mRNA

NCBI chr17:12,029,189...12,068,234
Ensembl chr17:12,029,189...12,068,234

G

serine and arginine rich splicing factor 2

increases expression

ISO

kojic acid results in increased expression of SRSF2 mRNA

NCBI chr10:102,550,962...102,554,200
Ensembl chr10:102,553,072...102,554,141

G

SSX family member 1

increases expression

ISO

kojic acid results in increased expression of SSX1 mRNA

NCBI chr X:16,603,888...16,612,203
Ensembl chr X:16,604,449...16,612,210

G

ST13, Hsp70 interacting protein

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of ST13 mRNA

NCBI chr 7:114,769,758...114,805,877
Ensembl chr 7:114,769,759...114,805,941

G

ST18 C2H2C-type zinc finger transcription factor

decreases expression

ISO

kojic acid results in decreased expression of ST18 mRNA

NCBI chr 5:17,369,383...17,701,094
Ensembl chr 5:17,371,000...17,458,676

G

StAR-related lipid transfer domain containing 8

decreases expression

ISO

kojic acid results in decreased expression of STARD8 mRNA

NCBI chr X:68,119,276...68,236,247
Ensembl chr X:68,119,644...68,236,246

G

syntaxin 6

increases expression

ISO

kojic acid results in increased expression of STX6 mRNA

NCBI chr13:69,882,647...69,928,895
Ensembl chr13:69,882,620...69,931,036

G

sulfotransferase family 1A member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1A1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of SULT1A1 mRNA

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

sulfotransferase family 1B member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1B1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of SULT1B1 mRNA

NCBI chr14:20,771,917...20,784,665
Ensembl chr14:20,771,868...20,785,549

G

sulfotransferase family 1C member 2A

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1C2 mRNA

NCBI chr 9:7,075,873...7,103,316
Ensembl chr 9:7,066,905...7,244,132

G

sulfotransferase family 1C member 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1C1 mRNA

NCBI chr 9:7,548,839...7,594,299
Ensembl chr 9:7,548,622...7,594,295

G

sulfotransferase family 1E member 1

multiple interactions

EXP
ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA
[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of SULT1E1 mRNA

PMID:17917374 PMID:18544905

NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716

G

sulfotransferase family 4A, member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of SULT4A1 mRNA

NCBI chr 7:117,096,064...117,120,714
Ensembl chr 7:117,096,064...117,120,083

G

SUZ12 polycomb repressive complex 2 subunit

decreases expression

ISO

kojic acid results in decreased expression of SUZ12 mRNA

NCBI chr10:65,464,948...65,510,846
Ensembl chr10:65,464,969...65,510,846

G

switching B-cell complex subunit SWAP70

increases expression

ISO

kojic acid results in increased expression of SWAP70 mRNA

NCBI chr 1:173,702,338...173,763,540
Ensembl chr 1:173,702,347...173,763,947

G

SYF2 pre-mRNA-splicing factor

decreases expression

ISO

kojic acid results in decreased expression of SYF2 mRNA

NCBI chr 5:152,440,171...152,448,094
Ensembl chr 5:152,440,054...152,448,092

G

symplekin scaffold protein

decreases expression

ISO

kojic acid results in decreased expression of SYMPK mRNA

NCBI chr 1:87,800,416...87,828,727
Ensembl chr 1:87,799,853...87,828,727

G

synaptotagmin binding, cytoplasmic RNA interacting protein

increases expression

ISO

kojic acid results in increased expression of SYNCRIP mRNA

NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:98,282,358...98,315,386

G

TATA-box binding protein associated factor 15

decreases expression

ISO

kojic acid results in decreased expression of TAF15 mRNA

NCBI chr10:68,770,408...68,802,458
Ensembl chr10:68,770,430...68,802,458

G

TAL bHLH transcription factor 1, erythroid differentiation factor

decreases expression

ISO

kojic acid results in decreased expression of TAL1 mRNA

NCBI chr 5:133,823,093...133,837,737
Ensembl chr 5:133,826,003...133,837,738

G

thromboxane A synthase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TBXAS1 mRNA

NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:68,631,838...68,803,969

G

transcription factor 21

decreases expression

ISO

kojic acid results in decreased expression of TCF21 mRNA

NCBI chr 1:24,520,499...24,523,358
Ensembl chr 1:24,520,481...24,523,348

G

terminal nucleotidyltransferase 4B

decreases expression

ISO

kojic acid results in decreased expression of TENT4B mRNA

NCBI chr19:34,984,244...35,042,423
Ensembl chr19:34,980,296...35,042,399

G

transforming growth factor, beta 1

multiple interactions

EXP

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

thyroid hormone receptor beta

decreases expression

ISO

kojic acid results in decreased expression of THRB mRNA

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

decreases expression

ISO

kojic acid results in decreased expression of TIE mRNA

NCBI chr 5:137,285,408...137,305,047
Ensembl chr 5:137,285,408...137,304,981

G

TIR domain containing adaptor protein

decreases expression

ISO

kojic acid results in decreased expression of TIRAP mRNA

NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:41,791,878...41,796,312

G

transmembrane and coiled-coil domains 5A

increases expression

ISO

kojic acid results in increased expression of TMCO5 mRNA

NCBI chr 3:124,187,005...124,200,308
Ensembl chr 3:124,187,067...124,200,308

G

transmembrane protein 217

increases expression

ISO

kojic acid results in increased expression of TMEM217 mRNA

NCBI chr20:7,594,223...7,620,628
Ensembl chr20:7,594,405...7,620,558

G

transmembrane protein 59-like

decreases expression

ISO

kojic acid results in decreased expression of TMEM59L mRNA

NCBI chr16:18,975,217...18,979,354
Ensembl chr16:18,974,709...18,981,586

G

thioredoxin-related transmembrane protein 1

decreases expression

ISO

kojic acid results in decreased expression of TMX1 mRNA

NCBI chr 6:94,696,699...94,707,751
Ensembl chr 6:94,696,358...94,708,618

G

tumor necrosis factor

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TNF mRNA

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 8 like 1

decreases expression

ISO

kojic acid results in decreased expression of TNFAIP8L1 mRNA

NCBI chr 9:1,075,724...1,088,256
Ensembl chr 9:1,055,801...1,092,803

G

TNF superfamily member 10

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TNFSF10 mRNA

NCBI chr 2:112,136,550...112,155,903

G

torsin family 4, member A

decreases expression

ISO

kojic acid results in decreased expression of TOR4A mRNA

NCBI chr 3:28,402,454...28,406,141
Ensembl chr 3:28,399,513...28,406,473

G

tumor protein p53

multiple interactions

EXP
ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TP53 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of TRP53 mRNA

PMID:17917374 PMID:18544905

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 binding protein, 2

increases expression

ISO

kojic acid results in increased expression of TP53BP2 mRNA

NCBI chr13:96,620,429...96,677,090
Ensembl chr13:96,620,428...96,677,616

G

two pore segment channel 1

increases expression

ISO

kojic acid results in increased expression of TPCN1 mRNA

NCBI chr12:41,633,399...41,690,200
Ensembl chr12:41,633,398...41,690,200

G

tyrosylprotein sulfotransferase 2

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TPST2 mRNA

NCBI chr12:49,982,281...50,024,489
Ensembl chr12:49,982,281...50,023,058

G

TNFRSF1A-associated via death domain

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TRADD mRNA; [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TRADD mRNA

NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550

G

translocation associated membrane protein 1

decreases expression

ISO

kojic acid results in decreased expression of TRAM1 mRNA

NCBI chr 5:10,425,710...10,450,669
Ensembl chr 5:10,425,633...10,470,056

G

translocation associated membrane protein 2

decreases expression

ISO

kojic acid results in decreased expression of TRAM2 mRNA

NCBI chr 9:30,915,624...30,995,162
Ensembl chr 9:30,915,624...30,995,162

G

triggering receptor expressed on myeloid cells 1

decreases expression

ISO

kojic acid results in decreased expression of TREM1 mRNA

NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:20,261,408...20,276,892

G

tRNA methyltransferase 10C, mitochondrial RNase P subunit

decreases expression

ISO

kojic acid results in decreased expression of TRMT10C mRNA

NCBI chr11:58,053,455...58,058,533
Ensembl chr11:58,033,201...58,059,062

G

tetraspanin 8

increases expression

ISO

kojic acid results in increased expression of TSPAN8 mRNA

NCBI chr 7:53,331,019...53,365,402
Ensembl chr 7:53,330,963...53,365,401

G

tetratricopeptide repeat domain 9

increases expression

ISO

kojic acid results in increased expression of TTC9 mRNA

NCBI chr 6:107,064,527...107,099,361
Ensembl chr 6:107,064,527...107,099,361

G

Ttk protein kinase

decreases expression

ISO

kojic acid results in decreased expression of TTK mRNA

NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:93,634,319...93,672,664

G

TUB like protein 3

decreases expression

ISO

kojic acid results in decreased expression of TULP3 mRNA

NCBI chr 4:163,276,583...163,318,297
Ensembl chr 4:163,276,583...163,318,390

G

twinfilin actin-binding protein 1

decreases expression

ISO

kojic acid results in decreased expression of TWF1 mRNA

NCBI chr 7:127,595,210...127,607,821
Ensembl chr 7:127,595,210...127,607,105

G

tyrosinase

decreases activity
increases expression

ISO

kojic acid results in decreased activity of TYR protein
kojic acid results in increased expression of TYR mRNA; kojic acid results in increased expression of TYR protein

PMID:23738040 PMID:27586645

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

tyrosinase-related protein 1

decreases expression

ISO

kojic acid results in decreased expression of TYRP1 protein

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:100,327,125...100,345,657

G

ubiquitin-conjugating enzyme E2D 2B

decreases expression

ISO

kojic acid results in decreased expression of UBE2D4 mRNA

NCBI chr14:2,060,926...2,062,400
Ensembl chr14:2,048,235...2,063,764

G

ubiquitin-conjugating enzyme E2E 1

decreases expression

ISO

kojic acid results in decreased expression of UBE2E1 mRNA

NCBI chr15:9,870,528...9,924,194
Ensembl chr15:9,862,219...9,924,194

G

ubiquitin-conjugating enzyme E2M

decreases expression

ISO

kojic acid results in decreased expression of UBE2M mRNA

NCBI chr 1:82,734,761...82,738,298
Ensembl chr 1:82,732,231...82,738,613

G

ubiquitin protein ligase E3 component n-recognin 7

increases expression

ISO

kojic acid results in increased expression of UBR7 mRNA

NCBI chr 6:127,663,454...127,683,302
Ensembl chr 6:127,663,447...127,694,390

G

ubiquitin recognition factor in ER associated degradation 1

increases expression

ISO

kojic acid results in increased expression of UFD1 mRNA

NCBI chr11:95,665,971...95,689,423
Ensembl chr11:95,665,972...95,689,434

G

UDP glucuronosyltransferase 1 family, polypeptide A2

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of UGT1A2 mRNA

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A6a

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of UGT1A6 mRNA

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

unc-5 netrin receptor C

decreases expression

ISO

kojic acid results in decreased expression of UNC5C mRNA

NCBI chr 2:232,854,352...233,208,482
Ensembl chr 2:232,846,262...233,208,482

G

uracil-DNA glycosylase

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of UNG mRNA

NCBI chr12:48,145,838...48,154,789
Ensembl chr12:48,145,838...48,155,257

G

ubiquitin specific peptidase 1

decreases expression

ISO

kojic acid results in decreased expression of USP1 mRNA

NCBI chr 5:118,703,056...118,714,426
Ensembl chr 5:118,702,868...118,714,434

G

ubiquitin specific peptidase 44

decreases expression

ISO

kojic acid results in decreased expression of USP44 mRNA

NCBI chr 7:30,251,142...30,301,185
Ensembl chr 7:30,251,205...30,297,906

G

UTP11, small subunit processome component

increases expression

ISO

kojic acid results in increased expression of UTP11 mRNA

NCBI chr 5:142,215,974...142,230,859
Ensembl chr 5:142,215,975...142,230,859

G

Wnt family member 10A

decreases expression

ISO

kojic acid results in decreased expression of WNT10A mRNA

NCBI chr 9:83,798,594...83,811,060
Ensembl chr 9:83,798,594...83,811,067

G

YEATS domain containing 2

increases expression

ISO

kojic acid results in increased expression of YEATS2 mRNA

NCBI chr11:94,247,538...94,333,652
Ensembl chr11:94,247,538...94,333,292

G

zinc finger CCCH-type containing 15

decreases expression

ISO

kojic acid results in decreased expression of ZC3H15 mRNA

NCBI chr 3:89,151,432...89,171,203
Ensembl chr 3:89,151,509...89,171,202

G

zinc finger DHHC-type palmitoyltransferase 20

decreases expression

ISO

kojic acid results in decreased expression of ZDHHC20 mRNA

NCBI chr15:36,095,624...36,154,546
Ensembl chr15:36,098,282...36,154,532

G

zinc finger AN1-type containing 1

decreases expression

ISO

kojic acid results in decreased expression of ZFAND1 mRNA

NCBI chr 2:93,351,918...93,364,959
Ensembl chr 2:93,351,917...93,360,665

G

zinc finger protein 146

decreases expression

ISO

kojic acid results in decreased expression of ZNF146 mRNA

NCBI chr 1:94,537,054...94,549,315
Ensembl chr 1:94,536,083...94,551,860

G

zinc finger protein 414

decreases expression

ISO

kojic acid results in decreased expression of ZNF414 mRNA

NCBI chr 7:15,122,408...15,125,115
Ensembl chr 7:15,122,401...15,125,755

G

zinc finger protein 438

increases expression

ISO

kojic acid results in increased expression of ZNF438 mRNA

NCBI chr17:57,121,637...57,242,892
Ensembl chr17:57,121,302...57,245,607

G

zinc finger protein 483

decreases expression

ISO

kojic acid results in decreased expression of ZNF483 mRNA

NCBI chr 5:78,558,213...78,575,559
Ensembl chr 5:78,558,304...78,575,552

G

zinc finger with KRAB and SCAN domains 8

decreases expression

ISO

kojic acid results in decreased expression of ZKSCAN8 mRNA

NCBI chr17:47,735,120...47,753,126
Ensembl chr17:47,735,120...47,753,126

G

zinc finger, MYND-type containing 15

decreases expression

ISO

kojic acid results in decreased expression of ZMYND15 mRNA

NCBI chr10:55,669,832...55,676,446
Ensembl chr10:55,669,752...55,676,434

G

zona pellucida glycoprotein 2

decreases expression

ISO

kojic acid results in decreased expression of ZP2 mRNA

NCBI chr 1:183,944,840...183,956,619
Ensembl chr 1:183,939,880...183,963,075

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dual specificity tyrosine phosphorylation regulated kinase 1A

multiple interactions

ISO

licocoumarone binds to and results in decreased activity of DYRK1A protein

NCBI chr11:47,360,824...47,479,033
Ensembl chr11:47,360,850...47,479,033

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression

ISO

licocoumarone results in decreased expression of MET protein

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

ISO

Methylene Blue results in decreased activity of ACHE protein

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

ATPase Na+/K+ transporting subunit alpha 2

multiple interactions

ISO

Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of ATP1A2 protein]

NCBI chr13:87,261,964...87,286,911
Ensembl chr13:87,261,968...87,286,911

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

EXP

Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

calcium voltage-gated channel subunit alpha1 C

multiple interactions

ISO

Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of CACNA1C protein]

NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762

G

calcitonin-related polypeptide alpha

multiple interactions

EXP

Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

glucose-6-phosphate dehydrogenase

increases activity

ISO

Methylene Blue results in increased activity of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

ISO

[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions

ISO

[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glial fibrillary acidic protein

multiple interactions

ISO

Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein]

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

glutaredoxin

multiple interactions

ISO

[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA

NCBI chr 2:7,073,737...7,083,548
Ensembl chr 2:7,073,759...7,083,543

G

glutaredoxin 2

multiple interactions

ISO

[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA

NCBI chr13:58,032,199...58,055,061
Ensembl chr13:58,032,401...58,043,150

G

gonadotropin releasing hormone 1

multiple interactions

EXP

Methylene Blue inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]

NCBI chr15:46,147,878...46,152,086
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977

G

glutathione S-transferase pi 1

multiple interactions

ISO

Methylene Blue inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

heme oxygenase 1

multiple interactions
increases expression

ISO
EXP

[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]
Methylene Blue results in increased expression of HMOX1 protein

PMID:24556215 PMID:25943564

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

intercellular adhesion molecule 1

multiple interactions

EXP

Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interleukin 17A

multiple interactions

EXP

Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein]

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 6

multiple interactions

EXP

Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

iodotyrosine deiodinase

multiple interactions

ISO

Methylene Blue inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]

NCBI chr 1:42,410,099...42,425,414
Ensembl chr 1:42,410,130...42,426,386

G

monoamine oxidase B

multiple interactions
decreases activity

ISO

Methylene Blue inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]
Methylene Blue results in decreased activity of MAOB protein

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

microtubule-associated protein tau

decreases expression
multiple interactions
decreases phosphorylation
increases expression

ISO

Methylene Blue results in decreased expression of MAPT protein
[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA; Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA]; Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA]; Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein]
Methylene Blue results in decreased phosphorylation of MAPT protein modified form
Methylene Blue results in increased expression of MAPT mRNA

PMID:16930453 PMID:24556215

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

myeloperoxidase

multiple interactions

EXP

Methylene Blue inhibits the reaction [Paraquat results in increased expression of MPO protein]; Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]

PMID:25943564 PMID:31428839

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO
EXP

[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]

PMID:24556215 PMID:31428839

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nitric oxide synthase 2

multiple interactions

ISO
EXP

Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]

PMID:24556215 PMID:31428839

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

ISO

[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

phosphogluconate dehydrogenase

increases activity

ISO

Methylene Blue results in increased activity of PGD protein

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

peroxiredoxin 6

multiple interactions

ISO

[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA

NCBI chr13:76,062,082...76,072,631
Ensembl chr13:76,061,554...76,072,657

G

protein kinase C, epsilon

multiple interactions

ISO

Methylene Blue inhibits the reaction [Sodium Cyanide results in increased activity of and affects the localization of PRKCE protein]

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

solute carrier family 2 member 1

multiple interactions
increases activity

ISO

oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein]

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

tumor necrosis factor

multiple interactions

EXP

Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

affects activity

ISO

Methylene Blue affects the activity of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

thioredoxin 1

multiple interactions

ISO

Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA]

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin 2

multiple interactions

ISO

[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA

NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022

G

thioredoxin reductase 1

multiple interactions

ISO

Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA]

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

thioredoxin reductase 2

multiple interactions

ISO

[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA

NCBI chr11:96,024,321...96,072,475
Ensembl chr11:96,024,324...96,072,475

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression

EXP

Monocrotophos results in increased expression of ABCA1 mRNA

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

acetyl-CoA carboxylase alpha

increases expression
increases activity

EXP

Monocrotophos results in increased expression of ACACA mRNA
Monocrotophos results in increased activity of ACACA protein

PMID:32207356 PMID:32267039

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acetylcholinesterase

multiple interactions
decreases expression
decreases activity

ISO
EXP

asoxime chloride inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]
Monocrotophos results in decreased expression of ACHE mRNA
[Dichlorvos co-treated with Monocrotophos] results in increased activity of ACHE protein; [Monocrotophos co-treated with Dichlorvos] results in decreased activity of ACHE protein; [sodium arsenite co-treated with Dichlorvos co-treated with Monocrotophos] results in decreased activity of ACHE protein

PMID:8783813 PMID:15679473 PMID:15793557 PMID:19730754 PMID:20026515 More...

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

adiponectin, C1Q and collagen domain containing

decreases expression

EXP

Monocrotophos results in decreased expression of ADIPOQ protein

PMID:32207356 PMID:32267039

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

aryl hydrocarbon receptor

affects expression
increases expression
multiple interactions

ISO

Monocrotophos affects the expression of AHR protein
Monocrotophos results in increased expression of AHR mRNA
[Monocrotophos co-treated with Cimetidine] results in increased expression of AHR protein; [Rifampin co-treated with Monocrotophos] results in decreased expression of AHR mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of AHR protein

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
decreases expression

ISO

Monocrotophos promotes the reaction [AIFM1 protein binds to NFE2L2 protein]
Monocrotophos results in decreased expression of AIFM1 protein

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions
increases expression

ISO

Monocrotophos results in increased expression of and affects the localization of APEX1 protein
Monocrotophos results in increased expression of APEX1 mRNA

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

EXP

Monocrotophos results in increased expression of and affects the localization of BAX protein; resveratrol inhibits the reaction [Monocrotophos results in increased expression of BAX mRNA]; resveratrol inhibits the reaction [Monocrotophos results in increased expression of BAX protein]
Monocrotophos results in increased expression of BAX mRNA; Monocrotophos results in increased expression of BAX protein

PMID:20957986 PMID:21445290 PMID:23833438

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bcl-2 binding component 3

increases expression

EXP

Monocrotophos results in increased expression of BBC3 mRNA

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

butyrylcholinesterase

decreases activity

EXP

Monocrotophos results in decreased activity of BCHE protein

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL2, apoptosis regulator

increases expression
multiple interactions
decreases expression

EXP

Monocrotophos results in increased expression of BCL2 mRNA; Monocrotophos results in increased expression of BCL2 protein
resveratrol inhibits the reaction [Monocrotophos results in decreased expression of BCL2 mRNA]; resveratrol inhibits the reaction [Monocrotophos results in decreased expression of BCL2 protein]
Monocrotophos results in decreased expression of BCL2 mRNA; Monocrotophos results in decreased expression of BCL2 protein

PMID:20957986 PMID:21445290 PMID:23833438

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 2

decreases expression

EXP

Monocrotophos results in decreased expression of BCL2L2 mRNA; Monocrotophos results in decreased expression of BCL2L2 protein

PMID:20957986 PMID:21445290

NCBI chr15:32,326,686...32,337,834
Ensembl chr15:32,326,020...32,335,379

G

caspase 3

increases expression
multiple interactions

EXP

Monocrotophos results in increased expression of CASP3 mRNA; Monocrotophos results in increased expression of CASP3 protein; Monocrotophos results in increased expression of CASP3 protein modified form
resveratrol inhibits the reaction [Monocrotophos results in increased expression of CASP3 mRNA]; resveratrol inhibits the reaction [Monocrotophos results in increased expression of CASP3 protein]

PMID:20957986 PMID:21445290 PMID:23833438

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

increases expression

EXP

Monocrotophos results in increased expression of CASP9 mRNA; Monocrotophos results in increased expression of CASP9 protein; Monocrotophos results in increased expression of CASP9 protein modified form

PMID:20957986 PMID:21445290

Ensembl chr 5:159,391,188...159,409,648

G

catalase

decreases activity

EXP

Monocrotophos results in decreased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin-dependent kinase inhibitor 1A

increases expression

EXP

Monocrotophos results in increased expression of CDKN1A mRNA; Monocrotophos results in increased expression of CDKN1A protein

PMID:20957986 PMID:21445290

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cytochrome c oxidase subunit 4i1

multiple interactions
decreases expression

EXP

Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of COX4I1 mRNA]

NCBI chr19:65,630,383...65,636,623
Ensembl chr19:65,630,432...65,636,624

G

cytochrome c, somatic

multiple interactions

EXP

Monocrotophos results in increased expression of and affects the localization of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions
increases activity

EXP
ISO

Monocrotophos results in increased expression of CYP1A1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP1A1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP1A1 protein
Monocrotophos results in increased expression of CYP1A1 mRNA; Monocrotophos results in increased expression of CYP1A1 protein
Monocrotophos results in increased activity of CYP1A1 protein

PMID:21445290 PMID:22733800

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

EXP

Monocrotophos results in increased expression of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

EXP

Monocrotophos results in increased expression of CYP2B2 protein

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases activity
increases expression
multiple interactions

ISO

Monocrotophos results in increased activity of CYP2B6 protein
Monocrotophos results in increased expression of CYP2B6 mRNA; Monocrotophos results in increased expression of CYP2B6 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP2B6 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2B6 protein

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression
multiple interactions
increases activity

EXP
ISO

Monocrotophos results in increased expression of CYP2E1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP2E1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP2E1 protein
Monocrotophos results in increased expression of CYP2E1 mRNA; Monocrotophos results in increased expression of CYP2E1 protein
Monocrotophos results in increased activity of CYP2E1 protein

PMID:21445290 PMID:22733800

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases activity
multiple interactions
increases expression

ISO

Monocrotophos results in increased activity of CYP3A4 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein; [Rifampin co-treated with Monocrotophos] results in increased activity of CYP3A4 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of CYP3A4 protein
Monocrotophos results in increased expression of CYP3A4 mRNA; Monocrotophos results in increased expression of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450 family 7 subfamily A member 1

increases expression

EXP

Monocrotophos results in increased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

diacylglycerol O-acyltransferase 1

increases expression

EXP

Monocrotophos results in increased expression of DGAT1 mRNA

NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016

G

fatty acid synthase

increases activity
increases expression

EXP

Monocrotophos results in increased activity of FASN protein
Monocrotophos results in increased expression of FASN mRNA

PMID:32207356 PMID:32267039

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

EXP

Monocrotophos results in increased expression of FOS protein

PMID:20957986 PMID:21445290

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

glucose-6-phosphate dehydrogenase

affects activity
increases activity
multiple interactions

EXP

Monocrotophos affects the activity of G6PD protein
Monocrotophos results in increased activity of G6PD protein
[Monocrotophos co-treated with quinalphos] affects the activity of G6PD protein

PMID:24248738 PMID:32207356 PMID:32267039

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

glyceraldehyde-3-phosphate dehydrogenase

increases activity

EXP

Monocrotophos results in increased activity of GAPDH protein

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

glucokinase

increases activity

EXP

Monocrotophos results in increased activity of GCK protein

NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949

G

glutathione-disulfide reductase

decreases activity
multiple interactions
affects activity

EXP

Monocrotophos results in decreased activity of GSR protein
[Monocrotophos co-treated with quinalphos] affects the activity of GSR protein
Monocrotophos affects the activity of GSR protein

PMID:22751200 PMID:24248738

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase pi 1

increases expression
multiple interactions

EXP
ISO

Monocrotophos results in increased expression of GSTP1 mRNA; Monocrotophos results in increased expression of GSTP1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of GSTP1 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of GSTP1 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of GSTP1 protein

PMID:21445290 PMID:22733800

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression

EXP

Monocrotophos results in increased expression of HMGCR mRNA

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

interleukin 2

decreases response to substance

ISO

Monocrotophos results in decreased susceptibility to IL2 protein

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

insulin 1

increases expression

EXP

Monocrotophos results in increased expression of INS1 protein

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

EXP
ISO

Monocrotophos results in increased expression of JUN protein
Monocrotophos results in increased expression of and results in increased phosphorylation of JUN protein

PMID:20957986 PMID:21445290 PMID:28887667

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

low density lipoprotein receptor

increases expression

EXP

Monocrotophos results in increased expression of LDLR mRNA

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

leptin

increases expression

EXP

Monocrotophos results in increased expression of LEP protein

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

DNA ligase 3

increases expression

ISO

Monocrotophos results in increased expression of LIG3 mRNA

NCBI chr10:68,215,371...68,238,705
Ensembl chr10:68,215,407...68,238,704

G

lipin 1

increases activity
affects expression

EXP

Monocrotophos results in increased activity of LPIN1 protein
Monocrotophos affects the expression of LPIN1 mRNA

PMID:32207356 PMID:32267039

NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991

G

lipoprotein lipase

increases expression
decreases activity

EXP

Monocrotophos results in increased expression of LPL mRNA
Monocrotophos results in decreased activity of LPL protein

PMID:32207356 PMID:32267039

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

monoamine oxidase A

decreases activity

EXP

Monocrotophos results in decreased activity of MAOA protein

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

decreases activity

EXP

Monocrotophos results in decreased activity of MAOB protein

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

EXP

Monocrotophos results in decreased expression of MCL1 mRNA; Monocrotophos results in decreased expression of MCL1 protein

PMID:20957986 PMID:21445290

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

multiple interactions
decreases expression

EXP

Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of ND1 mRNA]

NCBI chr MT:2,740...3,694
Ensembl chr MT:2,729...3,685

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2

decreases expression
multiple interactions

EXP

Monocrotophos results in decreased expression of ND2 mRNA
Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of ND2 mRNA]

NCBI chr MT:3,904...4,942
Ensembl chr MT:3,892...4,929

G

nestin

decreases expression
increases expression

ISO

Monocrotophos results in decreased expression of NES mRNA
Monocrotophos results in increased expression of NES protein

NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228

G

NFE2 like bZIP transcription factor 2

increases expression
decreases expression
multiple interactions

ISO
EXP

Monocrotophos results in increased expression of NFE2L2 protein
Monocrotophos results in decreased expression of NFE2L2 mRNA
Monocrotophos promotes the reaction [AIFM1 protein binds to NFE2L2 protein]

PMID:28887667 PMID:33078895 PMID:35403558

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear receptor subfamily 1, group I, member 2

affects expression
multiple interactions

ISO

Monocrotophos affects the expression of NR1I2 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I2 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
increases expression
decreases expression

ISO

[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I3 protein; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I3 mRNA; [Rifampin co-treated with Monocrotophos] results in increased expression of NR1I3 protein
Monocrotophos results in increased expression of NR1I3 mRNA; Monocrotophos results in increased expression of NR1I3 protein
Monocrotophos results in decreased expression of NR1I3 protein

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

nuclear respiratory factor 1

multiple interactions
decreases expression

EXP

Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of NRF1 mRNA]

NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353

G

8-oxoguanine DNA glycosylase

decreases expression

ISO

Monocrotophos results in decreased expression of OGG1 mRNA

NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604

G

poly (ADP-ribose) polymerase 1

increases expression

ISO

Monocrotophos results in increased expression of PARP1 mRNA; Monocrotophos results in increased expression of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

peroxisome proliferator activated receptor alpha

decreases expression

EXP

Monocrotophos results in decreased expression of PPARA mRNA

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor gamma

increases expression

EXP

Monocrotophos results in increased expression of PPARG mRNA

PMID:32207356 PMID:32267039

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

decreases expression
multiple interactions

EXP

Monocrotophos results in decreased expression of PPARGC1A mRNA
Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of PPARGC1A mRNA]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

scavenger receptor class B, member 1

increases expression

EXP

Monocrotophos results in increased expression of SCARB1 mRNA

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

superoxide dismutase 2

decreases expression
multiple interactions

EXP

Monocrotophos results in decreased expression of SOD2 mRNA
Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of SOD2 mRNA]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

sterol regulatory element binding transcription factor 1

increases expression

EXP

Monocrotophos results in increased expression of SREBF1 mRNA

PMID:32207356 PMID:32267039

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

sterol regulatory element binding transcription factor 2

increases expression

EXP

Monocrotophos results in increased expression of SREBF2 mRNA

NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943

G

tachykinin, precursor 1

multiple interactions

ISO

[perfluorooctanoic acid co-treated with Monocrotophos] results in decreased expression of TAC1 mRNA

NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546

G

transcription factor A, mitochondrial

multiple interactions
decreases expression

EXP

Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of TFAM mRNA]

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

tyrosine hydroxylase

multiple interactions
increases activity

EXP

Mifepristone inhibits the reaction [Monocrotophos results in increased activity of TH protein]

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

tumor necrosis factor

increases expression

EXP

Monocrotophos results in increased expression of TNF protein

PMID:32207356 PMID:32267039

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

increases expression

EXP

Monocrotophos results in increased expression of TP53 mRNA; Monocrotophos results in increased expression of TP53 protein; Monocrotophos results in increased expression of TRP53 mRNA; Monocrotophos results in increased expression of TRP53 protein

PMID:20957986 PMID:21445290

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression

ISO

Omeprazole results in increased expression of ABCA1 mRNA

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

Omeprazole results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

affects expression
multiple interactions

EXP
ISO

Omeprazole affects the expression of ABCB1A mRNA
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1 protein]
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1A protein]

PMID:19483382 PMID:30452898

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily B member 4

decreases expression

ISO

Omeprazole results in decreased expression of ABCB4 mRNA

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 2

multiple interactions

ISO

[Omeprazole results in increased susceptibility to Cisplatin] which results in decreased expression of ABCC2 protein

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

increases expression

EXP

Omeprazole results in increased expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 6

affects expression

EXP

Omeprazole affects the expression of ABCC6 mRNA

NCBI chr 1:105,583,681...105,637,895
Ensembl chr 1:105,583,682...105,637,895

G

ATP binding cassette subfamily G member 2

increases expression
multiple interactions

ISO

Omeprazole results in increased expression of ABCG2 mRNA alternative form; Omeprazole results in increased expression of ABCG2 protein
Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow]

PMID:20804740 PMID:31348918

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

ATP binding cassette subfamily G member 5

affects expression

EXP

Omeprazole affects the expression of ABCG5 mRNA

NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376

G

abhydrolase domain containing 1

affects expression

EXP

Omeprazole affects the expression of ABHD1 mRNA

NCBI chr 6:31,142,476...31,147,464
Ensembl chr 6:31,142,476...31,147,464

G

abhydrolase domain containing 14b

affects expression

EXP

Omeprazole affects the expression of ABHD14B mRNA

NCBI chr 8:115,966,792...115,970,829
Ensembl chr 8:115,965,932...115,970,833

G

abhydrolase domain containing 17A, depalmitoylase

affects expression

EXP

Omeprazole affects the expression of ABHD17A mRNA

NCBI chr 7:9,775,016...9,781,447

G

acetyl-CoA carboxylase alpha

affects expression

EXP

Omeprazole affects the expression of ACACA mRNA

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acyl-CoA dehydrogenase, long chain

affects expression

EXP

Omeprazole affects the expression of ACADL mRNA

NCBI chr 9:75,783,689...75,822,077
Ensembl chr 9:75,783,689...75,822,164

G

angiotensin converting enzyme 2

decreases expression

EXP
ISO

Omeprazole results in decreased expression of ACE2 mRNA

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

aconitase 1

affects expression

EXP

Omeprazole affects the expression of ACO1 mRNA

NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:60,055,866...60,112,600

G

aconitase 2

affects expression

EXP

Omeprazole affects the expression of ACO2 mRNA

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892

G

acyl-CoA thioesterase 12

affects expression

EXP

Omeprazole affects the expression of ACOT12 mRNA

NCBI chr 2:24,721,648...24,763,686
Ensembl chr 2:24,721,910...24,765,298

G

acyl-CoA thioesterase 4

affects expression

EXP

Omeprazole affects the expression of ACOT4 mRNA

NCBI chr 6:109,399,032...109,405,138
Ensembl chr 6:109,399,578...109,405,138

G

ADAM metallopeptidase domain 15

affects expression

EXP

Omeprazole affects the expression of ADAM15 mRNA

NCBI chr 2:177,052,363...177,062,879
Ensembl chr 2:177,052,363...177,062,849

G

adducin 1

affects expression

EXP

Omeprazole affects the expression of ADD1 mRNA

NCBI chr14:80,333,242...80,401,641
Ensembl chr14:80,333,244...80,391,732

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression

ISO

Omeprazole results in decreased expression of ADH1C mRNA

NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291

G

alcohol dehydrogenase 4 (class II), pi polypeptide

affects expression

EXP

Omeprazole affects the expression of ADH4 mRNA

NCBI chr 2:229,622,092...229,640,120
Ensembl chr 2:229,622,095...229,641,879

G

androgen-dependent TFPI-regulating protein

affects expression

EXP

Omeprazole affects the expression of ADTRP mRNA

NCBI chr17:23,113,578...23,199,616
Ensembl chr17:23,135,809...23,216,622

G

afamin

affects expression

EXP

Omeprazole affects the expression of AFM mRNA

NCBI chr14:17,815,194...17,848,042
Ensembl chr14:17,815,194...17,848,039

G

angiotensinogen

affects expression

EXP

Omeprazole affects the expression of AGT mRNA

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 1a

affects expression

EXP

Omeprazole affects the expression of AGTR1A mRNA

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

aryl hydrocarbon receptor

multiple interactions
increases response to substance
affects localization
decreases expression
increases expression
increases activity
decreases activity

ISO
EXP

AG-879 inhibits the reaction [Omeprazole results in increased activity of AHR protein]; AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of AHR mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]; Omeprazole binds to and results in increased activity of AHR protein; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; omeprazole sulfide inhibits the reaction [Omeprazole results in increased activity of AHR protein]; Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
AHR protein results in increased susceptibility to Omeprazole
Omeprazole affects the localization of AHR protein
Omeprazole results in decreased activity of AHR protein

PMID:9139728 PMID:9395520 PMID:14742684 PMID:16109480 PMID:20171196 More...

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldo-keto reductase family 1 member A1

affects expression

EXP

Omeprazole affects the expression of AKR1A1 mRNA

NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:135,329,606...135,367,035

G

aldo-keto reductase family 7, member A2

affects expression

EXP

Omeprazole affects the expression of AKR7A2 mRNA

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:156,835,551...156,844,109

G

aldo-keto reductase family 7 member A3

affects expression
multiple interactions

EXP

Omeprazole affects the expression of AKR7A3 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA

PMID:19483382 PMID:22687989

NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153

G

aldehyde dehydrogenase 1 family, member A1

affects expression
multiple interactions

EXP

Omeprazole affects the expression of ALDH1A1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA

PMID:19483382 PMID:22687989

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase 1 family, member A3

increases expression

ISO

Omeprazole results in increased expression of ALDH1A3 mRNA

NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:129,392,516...129,427,777

G

aldehyde dehydrogenase family 1, subfamily A7

affects expression

EXP

Omeprazole affects the expression of ALDH1A7 mRNA

NCBI chr 1:227,627,977...227,667,877
Ensembl chr 1:227,627,448...227,672,523

G

aldehyde dehydrogenase 2 family member

affects expression

EXP

Omeprazole affects the expression of ALDH2 mRNA

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219

G

aldehyde dehydrogenase 3 family, member A1

increases expression

ISO

Omeprazole results in increased expression of ALDH3A1 mRNA

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151

G

alkB homolog 7

affects expression

EXP

Omeprazole affects the expression of ALKBH7 mRNA

NCBI chr 9:1,925,896...1,928,048
Ensembl chr 9:1,925,743...1,928,048

G

adaptor related protein complex 2 subunit mu 1

affects expression

EXP

Omeprazole affects the expression of AP2M1 mRNA

NCBI chr11:93,859,690...93,868,600
Ensembl chr11:93,859,690...93,868,480

G

amyloid P component, serum

affects expression

EXP

Omeprazole affects the expression of APCS mRNA

NCBI chr13:87,905,532...87,906,508
Ensembl chr13:87,905,532...87,928,824

G

apolipoprotein A4

affects expression

EXP

Omeprazole affects the expression of APOA4 mRNA

NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164

G

apolipoprotein H

affects expression

EXP

Omeprazole affects the expression of APOH mRNA

NCBI chr10:93,841,992...93,855,897
Ensembl chr10:93,841,966...93,857,127

G

apolipoprotein O-like

affects expression

EXP

Omeprazole affects the expression of APOOL mRNA

NCBI chr X:81,569,960...81,635,906
Ensembl chr X:81,570,053...81,640,036

G

arginase 1

affects expression

EXP

Omeprazole affects the expression of ARG1 mRNA

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

ARL6 interacting reticulophagy regulator 1

affects expression

EXP

Omeprazole affects the expression of ARL6IP1 mRNA

NCBI chr 1:181,864,717...181,874,232
Ensembl chr 1:181,864,746...181,874,232

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions
affects localization

ISO
EXP

Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]
Omeprazole affects the localization of ARNT protein
Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]

PMID:9395520 PMID:21703235 PMID:25826687

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

asialoglycoprotein receptor 2

affects expression

EXP

Omeprazole affects the expression of ASGR2 mRNA

NCBI chr10:55,320,082...55,333,294
Ensembl chr10:55,320,091...55,333,263

G

activating transcription factor 5

affects expression

EXP

Omeprazole affects the expression of ATF5 mRNA

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183

G

ATP synthase F1 subunit epsilon

affects expression

EXP

Omeprazole affects the expression of ATP5F1E mRNA

NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:183,677,273...183,680,214

G

ATPase H+ transporting accessory protein 2

affects expression

EXP

Omeprazole affects the expression of ATP6AP2 mRNA

NCBI chr X:12,856,708...12,883,670
Ensembl chr X:12,855,859...12,905,875

G

ATPase H+ transporting V1 subunit A

affects expression

EXP

Omeprazole affects the expression of ATP6V1A mRNA

NCBI chr11:70,066,800...70,120,603
Ensembl chr11:70,035,134...70,120,603

G

ATPase H+ transporting V1 subunit F

affects expression

EXP

Omeprazole affects the expression of ATP6V1F mRNA

NCBI chr 4:59,033,020...59,035,980

G

ATPase copper transporting alpha

multiple interactions

ISO

Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole inhibits the reaction [Copper affects the localization of ATP7A protein]; Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein]

NCBI chr X:75,159,635...75,267,094
Ensembl chr X:75,159,782...75,267,093

G

bile acid CoA:amino acid N-acyltransferase

affects expression

EXP

Omeprazole affects the expression of BAAT mRNA

NCBI chr 5:68,647,166...68,656,137
Ensembl chr 5:68,646,203...68,656,181

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

Omeprazole inhibits the reaction [Cisplatin results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

Omeprazole inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL6B, transcription repressor

affects expression

EXP

Omeprazole affects the expression of BCL6B mRNA

NCBI chr10:55,439,566...55,444,631
Ensembl chr10:55,432,382...55,444,631

G

bridge-like lipid transfer protein family member 3B

affects expression

EXP

Omeprazole affects the expression of BLTP3B mRNA

NCBI chr 7:26,068,948...26,149,033
Ensembl chr 7:26,068,955...26,149,083

G

Bcl2 modifying factor

affects expression

EXP

Omeprazole affects the expression of BMF mRNA

NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258

G

BMX non-receptor tyrosine kinase

multiple interactions

ISO

BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]

NCBI chr X:33,859,128...33,921,876
Ensembl chr X:33,859,129...33,921,874

G

BCL2 interacting protein 3

affects expression

EXP

Omeprazole affects the expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

basic transcription factor 3

affects expression

EXP

Omeprazole affects the expression of BTF3 mRNA

NCBI chr 2:31,394,010...31,401,138
Ensembl chr 2:31,394,011...31,401,125
Ensembl chr13:31,394,011...31,401,125

G

complement C1q A chain

decreases expression

EXP

Omeprazole results in decreased expression of C1QA mRNA

NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:154,417,087...154,427,732

G

complement C1q binding protein

affects expression

EXP

Omeprazole affects the expression of C1QBP mRNA

NCBI chr10:56,198,534...56,203,185
Ensembl chr10:56,198,540...56,203,235

G

complement C1q C chain

decreases expression

EXP

Omeprazole results in decreased expression of C1QC mRNA

NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:154,410,848...154,414,468

G

complement C1s

affects expression

EXP

Omeprazole affects the expression of C1S mRNA

NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:159,116,549...159,128,736

G

C2 calcium-dependent domain containing 2

affects expression

EXP

Omeprazole affects the expression of C2CD2 mRNA

NCBI chr11:50,694,680...50,759,096
Ensembl chr11:50,694,563...50,759,016

G

complement component 4 binding protein, alpha

affects expression
decreases expression

EXP

Omeprazole affects the expression of C4BPA mRNA
Omeprazole results in decreased expression of C4BPA mRNA

PMID:19483382 PMID:25626140

NCBI chr13:44,627,959...44,663,552
Ensembl chr13:44,627,982...44,663,471

G

complement component 4 binding protein, beta

decreases expression

EXP

Omeprazole results in decreased expression of C4BPB mRNA

NCBI chr13:44,673,064...44,683,781
Ensembl chr13:44,673,065...44,683,793

G

complement C7

affects expression

EXP

Omeprazole affects the expression of C7 mRNA

NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:55,816,807...55,892,672

G

complement C8 beta chain

affects expression

EXP

Omeprazole affects the expression of C8B mRNA

NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:124,761,790...124,801,516

G

carbonic anhydrase 3

affects expression

EXP

Omeprazole affects the expression of CAR3 mRNA

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

calcium dependent secretion activator 2

affects expression

EXP

Omeprazole affects the expression of CADPS2 mRNA

NCBI chr 4:52,746,054...53,275,252
Ensembl chr 4:52,746,065...53,275,004

G

cell cycle associated protein 1

affects expression

EXP

Omeprazole affects the expression of CAPRIN1 mRNA

NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:110,606,489...110,685,562

G

carbonic anhydrase 2

affects expression

EXP

Omeprazole affects the expression of CA2 mRNA

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

caspase 3

increases activity
multiple interactions
affects expression
increases cleavage

ISO
EXP

Omeprazole analog results in increased activity of CASP3 protein; Omeprazole results in increased activity of CASP3 protein
Omeprazole inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Omeprazole inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
Omeprazole affects the expression of CASP3 mRNA
Omeprazole results in increased cleavage of CASP3 protein

PMID:15461867 PMID:18336733 PMID:19251492 PMID:19483382 PMID:25637687 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases cleavage

ISO

Omeprazole analog results in increased cleavage of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

catalase

increases activity
multiple interactions

EXP
ISO

Omeprazole results in increased activity of CAT protein
Omeprazole inhibits the reaction [Ethanol results in decreased activity of CAT protein]
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of CAT protein]

PMID:18547560 PMID:28849987 PMID:33245926

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

carbonyl reductase 1

affects expression

EXP

Omeprazole affects the expression of CBR1 mRNA

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

cholecystokinin B receptor

multiple interactions

ISO

[Omeprazole co-treated with CCKBR protein] results in increased expression of IER3

NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:169,183,194...169,193,745

G

cyclin D1

decreases expression

EXP

Omeprazole results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

Omeprazole results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cysteine dioxygenase type 1

affects expression

EXP

Omeprazole affects the expression of CDO1 mRNA

NCBI chr18:41,619,076...41,633,719
Ensembl chr18:41,619,070...41,633,891

G

choline/ethanolamine phosphotransferase 1

affects expression

EXP

Omeprazole affects the expression of CEPT1 mRNA

NCBI chr 2:196,682,455...196,724,430
Ensembl chr 2:196,681,681...196,723,812

G

carboxylesterase 2H

affects expression

EXP

Omeprazole affects the expression of CES2 mRNA

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752

G

complement factor I

affects expression
decreases expression

EXP

Omeprazole affects the expression of CFI mRNA
Omeprazole results in decreased expression of CFI mRNA

PMID:19483382 PMID:25626140

NCBI chr 2:221,062,206...221,104,790
Ensembl chr 2:221,062,212...221,104,786

G

CF transmembrane conductance regulator

affects metabolic processing

ISO

CFTR protein affects the metabolism of Omeprazole

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

calcineurin-like EF-hand protein 1

affects expression

EXP

Omeprazole affects the expression of CHP1 mRNA

NCBI chr 3:126,989,800...127,025,071
Ensembl chr 3:126,989,579...127,042,443

G

CDGSH iron sulfur domain 1

affects expression

EXP

Omeprazole affects the expression of CISD1 mRNA

NCBI chr20:17,254,462...17,267,843
Ensembl chr20:17,254,187...17,271,042

G

chloride voltage-gated channel 4

affects expression

EXP

Omeprazole affects the expression of CLCN4 mRNA

NCBI chr X:27,290,769...27,356,967
Ensembl chr X:27,290,868...27,356,939

G

caseinolytic mitochondrial matrix peptidase proteolytic subunit

affects expression

EXP

Omeprazole affects the expression of CLPP mRNA

NCBI chr 9:1,917,305...1,924,706
Ensembl chr 9:1,918,682...1,924,705

G

CLPTM1-like

affects expression

EXP

Omeprazole affects the expression of CLPTM1L mRNA

NCBI chr 1:31,496,094...31,512,148
Ensembl chr 1:31,496,094...31,512,077

G

carboxymethylenebutenolidase homolog

affects expression

EXP

Omeprazole affects the expression of CMBL mRNA

NCBI chr 2:84,280,128...84,301,878
Ensembl chr 2:84,242,512...84,301,880

G

cytidine/uridine monophosphate kinase 1

affects expression

EXP

Omeprazole affects the expression of CMPK1 mRNA

NCBI chr 5:133,717,073...133,744,623
Ensembl chr 5:133,717,086...133,744,596

G

COPI coat complex subunit gamma 1

affects expression

EXP

Omeprazole affects the expression of COPG1 mRNA

NCBI chr 4:121,923,644...121,949,819
Ensembl chr 4:121,923,873...121,949,812

G

COP9 signalosome subunit 4

affects expression

EXP

Omeprazole affects the expression of COPS4 mRNA

NCBI chr14:9,382,897...9,413,216
Ensembl chr14:9,382,900...9,413,107

G

coenzyme Q3 methyltransferase

affects expression

EXP

Omeprazole affects the expression of COQ3 mRNA

NCBI chr 5:40,226,313...40,257,383
Ensembl chr 5:40,226,368...40,257,617

G

cytochrome c oxidase subunit 4i1

affects expression

EXP

Omeprazole affects the expression of COX4I1 mRNA

NCBI chr19:65,630,383...65,636,623
Ensembl chr19:65,630,432...65,636,624

G

carboxypeptidase N subunit 1

affects expression

EXP

Omeprazole affects the expression of CPN1 mRNA

NCBI chr 1:252,793,786...252,822,675
Ensembl chr 1:252,793,423...252,822,664

G

carboxypeptidase Q

affects expression

EXP

Omeprazole affects the expression of CPQ mRNA

NCBI chr 7:66,148,973...66,719,189
Ensembl chr 7:66,149,377...66,716,137

G

cAMP responsive element modulator

affects expression

EXP

Omeprazole affects the expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

casein kinase 2 beta

affects expression

EXP

Omeprazole affects the expression of CSNK2B mRNA

NCBI chr20:3,704,833...3,709,999
Ensembl chr20:3,704,904...3,710,525

G

cysteine and glycine-rich protein 1

affects expression

EXP

Omeprazole affects the expression of CSRP1 mRNA

NCBI chr13:49,709,928...49,731,141
Ensembl chr13:49,709,914...49,731,139

G

catenin alpha 1

affects expression

EXP

Omeprazole affects the expression of CTNNA1 mRNA

NCBI chr18:27,002,330...27,135,009
Ensembl chr18:26,999,820...27,135,007

G

cathepsin B

decreases activity

ISO

Omeprazole results in decreased activity of CTSB protein

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin D

multiple interactions

EXP

Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein]

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cathepsin E

decreases expression

EXP

Omeprazole results in decreased expression of CTSE

NCBI chr13:45,644,168...45,666,722
Ensembl chr13:45,644,147...45,666,722

G

C-X-C motif chemokine receptor 4

decreases expression
multiple interactions

ISO

Omeprazole results in decreased expression of CXCR4 mRNA
AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
multiple interactions
decreases activity
increases expression

ISO
EXP

Omeprazole results in increased activity of CYP1A1 promoter
Omeprazole inhibits the reaction [Oxygen results in increased expression of CYP1A1 protein]; Omeprazole promotes the reaction [Oxygen results in decreased expression of CYP1A1 mRNA]
Omeprazole results in decreased activity of CYP1A1 protein
Omeprazole results in increased expression of CYP1A1 mRNA; Omeprazole results in increased expression of CYP1A1 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; lavendustin A inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Tosyllysine Chloromethyl Ketone inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]
AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]

PMID:8647108 PMID:8900397 PMID:9041675 PMID:9139728 PMID:9152597 More...

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases activity
increases expression
decreases activity
multiple interactions

ISO
EXP

Omeprazole results in increased activity of CYP1A2 promoter; Omeprazole results in increased activity of CYP1A2 protein
Omeprazole results in increased expression of CYP1A2 mRNA; Omeprazole results in increased expression of CYP1A2 protein
Omeprazole results in decreased activity of CYP1A2 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA
[Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; Omeprazole results in increased expression of and results in increased activity of CYP1A2 protein

PMID:9152597 PMID:9744552 PMID:12040753 PMID:12623754 PMID:12841937 More...

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
affects expression
decreases activity
increases expression

ISO

Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]
Omeprazole affects the expression of CYP1B1 mRNA
Omeprazole results in decreased activity of CYP1B1 protein
Omeprazole results in increased expression of CYP1B1 mRNA

PMID:12040753 PMID:12623754 PMID:18420780 PMID:21703235 PMID:25826687

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily a, polypeptide 1

affects expression

EXP

Omeprazole affects the expression of CYP2A1 mRNA

NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

EXP

Omeprazole results in increased expression of CYP2B1 mRNA; Omeprazole results in increased expression of CYP2B1 protein

PMID:9152597 PMID:19118567

NCBI chr 1:90,646,098...90,669,762

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression
affects expression

EXP

Omeprazole results in increased expression of CYP2B2 protein
Omeprazole affects the expression of CYP2B2 mRNA

PMID:9152597 PMID:19483382

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, family 2, subfamily b, polypeptide 3

affects expression
decreases activity
increases expression
increases activity

EXP
ISO

Omeprazole affects the expression of CYP2B3 mRNA
Omeprazole results in decreased activity of CYP2B10 protein
Omeprazole results in increased expression of CYP2B6 mRNA
Omeprazole results in increased activity of CYP2B6 protein

PMID:17954527 PMID:18420780 PMID:19118567 PMID:19483382 PMID:22524704

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases metabolic processing
decreases activity
multiple interactions
increases hydroxylation
increases metabolic processing
affects metabolic processing

ISO

CYP2C19 gene alternative form results in decreased metabolism of Omeprazole
Omeprazole results in decreased activity of CYP2C19 protein
[5-bromotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-chlorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [7-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Chloramphenicol results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [indopan results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Tryptamines analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]; Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Fluoxetine]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of 2-oxo-clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of Clopidogrel]
CYP2C19 protein results in increased hydroxylation of Omeprazole
CYP2C19 protein results in increased metabolism of Omeprazole
CYP2C19 protein affects the metabolism of Omeprazole

PMID:8930576 PMID:9600717 PMID:11752104 PMID:12464242 PMID:12467917 More...

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily d, polypeptide 1

increases expression

EXP

Omeprazole results in increased expression of CYP2D9 mRNA

NCBI chr 7:115,789,026...115,793,430
Ensembl chr 7:115,789,023...115,793,479

G

cytochrome P450, family 2, subfamily d, polypeptide 3

affects expression

EXP

Omeprazole affects the expression of CYP2D3 mRNA

NCBI chr 7:115,797,785...115,802,142
Ensembl chr 7:115,797,789...115,802,158

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects expression
decreases activity

EXP
ISO

Omeprazole affects the expression of CYP2D4 mRNA
Omeprazole results in decreased activity of CYP2D6 protein

PMID:18420780 PMID:19483382

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

ISO

Omeprazole results in increased expression of and results in increased activity of CYP2E1 protein

PMID:15802389 PMID:36243147

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 2, subfamily f, polypeptide 4

affects expression

EXP

Omeprazole affects the expression of CYP2F4 mRNA

NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:91,543,768...91,557,553

G

cytochrome P450, family 2, subfamily j, polypeptide 4

affects expression

EXP

Omeprazole affects the expression of CYP2J4 mRNA

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042

G

cytochrome P450, family 2, subfamily t, polypeptide 1

affects expression

EXP

Omeprazole affects the expression of CYP2T1 mRNA

NCBI chr 1:91,573,923...91,579,215
Ensembl chr 1:91,574,572...91,579,215

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects metabolic processing
increases metabolic processing
multiple interactions
increases expression

ISO

CYP3A4 protein affects the metabolism of Omeprazole
CYP3A4 protein results in increased metabolism of Omeprazole
[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]; Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Omeprazole results in increased expression of and results in increased activity of CYP3A4 protein
Omeprazole results in increased expression of CYP3A4 mRNA; Omeprazole results in increased expression of CYP3A4 protein

PMID:7870052 PMID:8930576 PMID:9744552 PMID:12235278 PMID:12485723 More...

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

affects expression
increases expression

EXP

Omeprazole affects the expression of CYP3A23-3A1 mRNA
Omeprazole results in increased expression of CYP3A23-3A1 mRNA

PMID:19118567 PMID:19483382

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects expression
increases expression

EXP
ISO

Omeprazole affects the expression of CYP3A9 mRNA
Omeprazole results in increased expression of CYP3A5 mRNA

PMID:19118567 PMID:19483382

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450, family 4, subfamily a, polypeptide 8

affects expression

EXP

Omeprazole affects the expression of CYP4A8 mRNA

NCBI chr 5:133,938,882...133,970,226
Ensembl chr 5:133,938,883...133,970,226

G

cytochrome P450, family 4, subfamily f, polypeptide 6

affects expression

EXP

Omeprazole affects the expression of CYP4F6 mRNA

NCBI chr 7:12,680,799...12,708,378
Ensembl chr 7:12,680,806...12,708,402

G

diazepam binding inhibitor

affects expression

EXP

Omeprazole affects the expression of DBI mRNA

NCBI chr13:33,794,231...33,802,632
Ensembl chr13:33,759,845...33,821,450

G

DDB1 and CUL4 associated factor 11

affects expression

EXP

Omeprazole affects the expression of DCAF11 mRNA

NCBI chr15:33,015,370...33,027,407
Ensembl chr15:33,016,762...33,027,672

G

dicarbonyl and L-xylulose reductase

affects expression

EXP

Omeprazole affects the expression of DCXR mRNA

NCBI chr10:106,504,730...106,506,619

G

DNA-damage inducible transcript 3

increases expression

ISO

Omeprazole results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

2,4-dienoyl-CoA reductase 1

affects expression

EXP

Omeprazole affects the expression of DECR1 mRNA

NCBI chr 5:34,208,195...34,236,074
Ensembl chr 5:34,208,195...34,236,033

G

Dexi homolog

affects expression

EXP

Omeprazole affects the expression of DEXI mRNA

NCBI chr10:5,632,400...5,645,653
Ensembl chr10:5,632,961...5,645,648

G

diacylglycerol O-acyltransferase 1

affects expression

EXP

Omeprazole affects the expression of DGAT1 mRNA

NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016

G

24-dehydrocholesterol reductase

affects expression

EXP

Omeprazole affects the expression of DHCR24 mRNA

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

dehydrogenase/reductase 4

affects expression

EXP

Omeprazole affects the expression of DHRS4 mRNA

NCBI chr15:32,924,482...32,948,103
Ensembl chr15:32,936,522...32,948,101

G

dehydrogenase/reductase 7B

affects expression

EXP

Omeprazole affects the expression of DHRS7B mRNA

NCBI chr10:46,003,845...46,036,498
Ensembl chr10:46,003,845...46,036,499

G

DEAH-box helicase 16

affects expression

EXP

Omeprazole affects the expression of DHX16 mRNA

NCBI chr20:2,866,804...2,879,790
Ensembl chr20:2,866,804...2,879,751

G

distal membrane arm assembly component 2 like

affects expression

EXP

Omeprazole affects the expression of DMAC2L mRNA

NCBI chr 6:93,941,605...93,959,932
Ensembl chr 6:93,941,690...93,960,662

G

DnaJ heat shock protein family (Hsp40) member C3

affects expression

EXP

Omeprazole affects the expression of DNAJC3 mRNA

NCBI chr15:102,432,667...102,475,643
Ensembl chr15:102,432,663...102,475,643

G

dipeptidylpeptidase 4

affects expression

EXP

Omeprazole affects the expression of DPP4 mRNA

NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422

G

dihydropyrimidine dehydrogenase

affects expression

EXP

Omeprazole affects the expression of DPYD mRNA

NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:209,293,929...210,159,778

G

glutamyl-tRNA synthetase 2, mitochondrial

affects expression

EXP

Omeprazole affects the expression of EARS2 mRNA

NCBI chr 1:186,025,740...186,057,165

G

enoyl-CoA hydratase, short chain 1

affects expression

EXP

Omeprazole affects the expression of ECHS1 mRNA

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506

G

enoyl-CoA delta isomerase 1

affects expression

EXP

Omeprazole affects the expression of ECI1 mRNA

NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773

G

enoyl-CoA delta isomerase 2

affects expression

EXP

Omeprazole affects the expression of ECI2 mRNA

NCBI chr17:30,056,274...30,092,169
Ensembl chr17:30,076,524...30,092,161

G

eukaryotic translation elongation factor 1 gamma

affects expression

EXP

Omeprazole affects the expression of EEF1G mRNA

NCBI chr 1:215,289,815...215,300,421
Ensembl chr 1:215,277,860...215,301,479

G

epidermal growth factor

multiple interactions

ISO

Omeprazole promotes the reaction [Indomethacin results in increased expression of EGF protein]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

affects expression

EXP

Omeprazole affects the expression of EHHADH mRNA

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662

G

eukaryotic translation initiation factor 4A2

affects expression

EXP

Omeprazole affects the expression of EIF4A2 mRNA

NCBI chr11:91,268,730...91,276,738
Ensembl chr11:91,268,731...91,275,323

G

eukaryotic translation initiation factor 4E binding protein 1

affects expression

EXP

Omeprazole affects the expression of EIF4EBP1 mRNA

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

eukaryotic translation initiation factor 4H

affects expression

EXP

Omeprazole affects the expression of EIF4H mRNA

NCBI chr12:27,719,527...27,736,350
Ensembl chr12:27,719,321...27,736,346

G

ectodermal-neural cortex 1

affects expression

EXP

Omeprazole affects the expression of ENC1 mRNA

NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721

G

enolase 1

affects expression

EXP

Omeprazole affects the expression of ENO1 mRNA

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

glutamyl aminopeptidase

affects expression

EXP

Omeprazole affects the expression of ENPEP mRNA

NCBI chr 2:220,456,258...220,526,218
Ensembl chr 2:220,456,278...220,526,218

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

affects expression

EXP

Omeprazole affects the expression of ENPP1 mRNA

NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:22,518,069...22,583,044

G

E1A binding protein p300

multiple interactions

ISO

Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

epithelial cell adhesion molecule

affects expression

EXP

Omeprazole affects the expression of EPCAM mRNA

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702

G

endoplasmic reticulum protein 29

affects expression

EXP

Omeprazole affects the expression of ERP29 mRNA

NCBI chr12:40,750,177...40,756,607
Ensembl chr12:40,750,314...40,757,010

G

esterase D

affects expression

EXP

Omeprazole affects the expression of ESD mRNA

NCBI chr15:56,453,082...56,472,582
Ensembl chr15:56,453,044...56,473,508

G

electron transfer flavoprotein subunit beta

affects expression

EXP

Omeprazole affects the expression of ETFB mRNA

NCBI chr 1:102,988,499...103,002,663
Ensembl chr 1:102,988,499...103,002,659

G

fatty acid amide hydrolase

affects expression

EXP

Omeprazole affects the expression of FAAH mRNA

NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:134,716,545...134,735,396

G

fatty acid desaturase 2

affects expression

EXP

Omeprazole affects the expression of FADS2 mRNA

NCBI chr 1:216,132,277...216,172,190
Ensembl chr 1:216,133,676...216,172,066

G

fructose-bisphosphatase 1

affects expression

EXP

Omeprazole affects the expression of FBP1 mRNA

NCBI chr17:2,212,941...2,235,749
Ensembl chr17:2,213,492...2,235,746

G

farnesyl diphosphate farnesyl transferase 1

affects expression

EXP

Omeprazole affects the expression of FDFT1 mRNA

NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168

G

farnesyl diphosphate synthase

affects expression

EXP

Omeprazole affects the expression of FDPS mRNA

NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136

G

ferredoxin 2

affects expression

EXP

Omeprazole affects the expression of FDX2 mRNA

NCBI chr 8:27,881,091...27,886,230
Ensembl chr 8:27,881,091...27,886,015

G

flavin containing dimethylaniline monoxygenase 1

affects expression

EXP

Omeprazole affects the expression of FMO1 mRNA

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

guanidinoacetate N-methyltransferase

affects expression

EXP

Omeprazole affects the expression of GAMT mRNA

NCBI chr 7:10,099,267...10,102,083
Ensembl chr 7:10,098,571...10,102,083

G

glyceraldehyde-3-phosphate dehydrogenase

affects expression

EXP

Omeprazole affects the expression of GAPDH mRNA

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

gastrin

increases expression

ISO
EXP

Omeprazole results in increased expression of GAST protein

PMID:11422300 PMID:12189558 PMID:12763636 PMID:15223672 PMID:16618411 More...

NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880

G

1,4-alpha-glucan branching enzyme 1

affects expression

EXP

Omeprazole affects the expression of GBE1 mRNA

NCBI chr11:22,181,194...22,446,640
Ensembl chr11:22,181,103...22,446,638

G

GTP cyclohydrolase I feedback regulator

affects expression

EXP

Omeprazole affects the expression of GCHFR mRNA

NCBI chr 3:126,611,892...126,615,926
Ensembl chr 3:126,613,240...126,615,926

G

gamma-glutamyl hydrolase

affects expression

EXP

Omeprazole affects the expression of GGH mRNA

NCBI chr 5:38,326,747...38,349,655
Ensembl chr 5:38,326,594...38,349,647

G

gamma-glutamyltransferase 1

multiple interactions

EXP

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

gap junction protein, beta 1

affects expression

EXP

Omeprazole affects the expression of GJB1 mRNA

NCBI chr X:70,541,845...70,549,776
Ensembl chr X:70,541,862...70,549,843

G

glycosylphosphatidylinositol specific phospholipase D1

affects expression

EXP

Omeprazole affects the expression of GPLD1 mRNA

NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,512,660...40,554,975

G

glutathione peroxidase 1

affects expression

EXP

Omeprazole affects the expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 2

multiple interactions

EXP

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutathione peroxidase 4

affects expression

EXP

Omeprazole affects the expression of GPX4 mRNA

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

affects expression

EXP

Omeprazole affects the expression of GRINA mRNA

NCBI chr 7:109,842,870...109,846,048
Ensembl chr 7:109,843,196...109,846,042

G

GrpE-like 1, mitochondrial

affects expression

EXP

Omeprazole affects the expression of GRPEL1 mRNA

NCBI chr14:78,517,049...78,522,868
Ensembl chr14:78,517,052...78,522,861

G

glutathione S-transferase alpha 5

increases expression
multiple interactions

EXP

Omeprazole results in increased expression of GSTA5 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA

PMID:17202759 PMID:22687989

NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765

G

glutathione S-transferase pi 1

increases expression

EXP

Omeprazole results in increased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

glutathione S-transferase theta 1

affects expression

EXP

Omeprazole affects the expression of GSTT1 mRNA

NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019

G

general transcription factor IIH subunit 5

affects expression

EXP

Omeprazole affects the expression of GTF2H5 mRNA

NCBI chr 1:49,061,904...49,068,612
Ensembl chr 1:49,061,959...49,070,039

G

gulonolactone (L-) oxidase

affects expression

EXP

Omeprazole affects the expression of GULO mRNA

NCBI chr15:44,381,226...44,403,314
Ensembl chr15:44,381,214...44,403,422

G

granzyme A

affects expression

EXP

Omeprazole affects the expression of GZMA mRNA

NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:46,473,763...46,485,696

G

H3.3 histone B

affects expression

EXP

Omeprazole affects the expression of H3F3B mRNA

NCBI chr10:101,755,404...101,764,616
Ensembl chr10:101,755,404...101,757,636

G

histidine ammonia lyase

affects expression

EXP

Omeprazole affects the expression of HAL mRNA

NCBI chr 7:29,894,495...29,924,744
Ensembl chr 7:29,893,855...29,924,744

G

hepcidin antimicrobial peptide

increases expression
multiple interactions
increases secretion

ISO

Omeprazole results in increased expression of HAMP mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]
Omeprazole results in increased expression of HAMP mRNA; Omeprazole results in increased expression of HAMP protein
Omeprazole results in increased secretion of HAMP protein

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

hydroxyacid oxidase 2

affects expression

EXP

Omeprazole affects the expression of HAO2 mRNA

NCBI chr 2:188,888,848...188,921,567
Ensembl chr 2:188,889,212...188,913,133

G

hemoglobin alpha, adult chain 2

affects expression

EXP

Omeprazole affects the expression of HBA-A2 mRNA

NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,828,377...15,829,141

G

hemoglobin subunit beta

affects expression

EXP

Omeprazole affects the expression of HBB mRNA

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873

G

histidine decarboxylase

affects expression
increases stability
increases expression
multiple interactions

EXP

Omeprazole affects the expression of HDC mRNA
Omeprazole results in increased stability of HDC protein
Omeprazole results in increased expression of HDC mRNA
Omeprazole results in increased expression of and results in increased activity of HDC protein

PMID:12763636 PMID:19483382

NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:134,300,632...134,318,711

G

homogentisate 1, 2-dioxygenase

affects expression

EXP

Omeprazole affects the expression of HGD mRNA

NCBI chr11:76,592,202...76,643,776
Ensembl chr11:76,592,204...76,643,767

G

high mobility group nucleosome binding domain 1

affects expression

EXP

Omeprazole affects the expression of HMGN1 mRNA

NCBI chr11:48,891,813...48,897,732
Ensembl chr11:48,891,814...48,897,771

G

heme oxygenase 1

multiple interactions
increases expression

ISO

Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]; Omeprazole results in increased expression of and results in increased activity of HMOX1 protein
Omeprazole results in increased expression of HMOX1 mRNA; Omeprazole results in increased expression of HMOX1 protein

PMID:16712795 PMID:27725188

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hypoxanthine phosphoribosyltransferase 1

affects expression

EXP

Omeprazole affects the expression of HPRT1 mRNA

NCBI chr X:137,655,744...137,687,718
Ensembl chr X:137,655,680...137,687,712

G

HPS5, biogenesis of lysosomal organelles complex 2 subunit 2

affects expression

EXP

Omeprazole affects the expression of HPS5 mRNA

NCBI chr 1:106,417,902...106,457,220
Ensembl chr 1:106,417,902...106,452,859

G

hydroxysteroid (17-beta) dehydrogenase 4

affects expression

EXP

Omeprazole affects the expression of HSD17B4 mRNA

NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467

G

hydroxysteroid dehydrogenase like 2

affects expression

EXP

Omeprazole affects the expression of HSDL2 mRNA

NCBI chr 5:79,238,881...79,274,051
Ensembl chr 5:79,212,525...79,274,798

G

heat shock protein family A (Hsp70) member 1A

decreases expression
multiple interactions

EXP

Omeprazole results in decreased expression of HSPA1A mRNA; Omeprazole results in decreased expression of HSPA1A protein
Zinc Compounds analog inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]

PMID:15223672 PMID:16945336

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

EXP

Omeprazole inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA]

NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877

G

HtrA serine peptidase 1

affects expression

EXP

Omeprazole affects the expression of HTRA1 mRNA

NCBI chr 1:194,928,069...194,977,619
Ensembl chr 1:194,927,687...194,977,620

G

immediate early response 3

multiple interactions

ISO

[Omeprazole co-treated with CCKBR protein] results in increased expression of IER3

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

interferon gamma

multiple interactions

ISO

Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

insulin-like growth factor 1

affects expression

EXP

Omeprazole affects the expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor binding protein, acid labile subunit

affects expression

EXP

Omeprazole affects the expression of IGFALS mRNA

NCBI chr10:14,397,076...14,408,439
Ensembl chr10:14,403,399...14,407,138

G

insulin-like growth factor binding protein 2

affects expression

EXP

Omeprazole affects the expression of IGFBP2 mRNA

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

interleukin 10

multiple interactions

ISO
EXP

Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein]

PMID:26970604 PMID:38341112

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 16

multiple interactions

EXP

Omeprazole inhibits the reaction [Ethanol results in increased expression of IL16 protein]

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023

G

interleukin 1 beta

multiple interactions

EXP

Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

EXP
ISO

Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL6 protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL6 protein]
Omeprazole inhibits the reaction [Ethanol results in increased expression of IL6 protein]

PMID:25637687 PMID:32418911 PMID:38341112

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inositol monophosphatase 1

affects expression

EXP

Omeprazole affects the expression of IMPA1 mRNA

NCBI chr 2:93,370,200...93,391,474
Ensembl chr 2:93,370,299...93,391,468

G

inhibin subunit beta E

affects expression

EXP

Omeprazole affects the expression of INHBE mRNA

NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519

G

inositol-3-phosphate synthase 1

affects expression

EXP

Omeprazole affects the expression of ISYNA1 mRNA

NCBI chr16:18,873,119...18,876,116
Ensembl chr16:18,873,121...18,875,955

G

inter-alpha-trypsin inhibitor heavy chain 4

affects expression

EXP

Omeprazole affects the expression of ITIH4 mRNA

NCBI chr16:6,086,985...6,102,162
Ensembl chr16:6,086,973...6,102,160

G

Janus kinase 1

affects expression

EXP

Omeprazole affects the expression of JAK1 mRNA

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

KDEL endoplasmic reticulum protein retention receptor 2

affects expression

EXP

Omeprazole affects the expression of KDELR2 mRNA

NCBI chr12:16,252,424...16,270,737
Ensembl chr12:16,252,424...16,270,719

G

kinase insert domain receptor

affects expression
multiple interactions

EXP
ISO

Omeprazole affects the expression of KDR mRNA
Omeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein]

PMID:19483382 PMID:26272953

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

keratin 8

affects expression

EXP

Omeprazole affects the expression of KRT8 mRNA

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

lecithin cholesterol acyltransferase

affects expression

EXP

Omeprazole affects the expression of LCAT mRNA

NCBI chr19:50,744,598...50,748,064
Ensembl chr19:50,744,601...50,748,081

G

leucine carboxyl methyltransferase 1

affects expression

EXP

Omeprazole affects the expression of LCMT1 mRNA

NCBI chr 1:187,335,173...187,391,195
Ensembl chr 1:187,327,706...187,391,516

G

lipase C, hepatic type

affects expression

EXP

Omeprazole affects the expression of LIPC mRNA

NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285

G

lysyl oxidase

affects expression

EXP

Omeprazole affects the expression of LOX mRNA

NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810

G

LDL receptor related protein 3

affects expression

EXP

Omeprazole affects the expression of LRP3 mRNA

NCBI chr 1:96,980,762...96,996,157
Ensembl chr 1:96,981,815...96,996,057

G

mannosidase, alpha, class 2B, member 1

affects expression

EXP

Omeprazole affects the expression of MAN2B1 mRNA

NCBI chr19:39,959,964...39,979,299
Ensembl chr19:39,959,965...39,979,246

G

mitogen activated protein kinase kinase 2

affects expression

EXP

Omeprazole affects the expression of MAP2K2 mRNA

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940

G

mitogen activated protein kinase 14

multiple interactions

ISO

Omeprazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

MBL associated serine protease 2

affects expression

EXP

Omeprazole affects the expression of MASP2 mRNA

NCBI chr 5:164,319,017...164,332,686
Ensembl chr 5:164,308,991...164,332,705

G

malic enzyme 1

affects expression
multiple interactions

EXP

Omeprazole affects the expression of ME1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA

PMID:19483382 PMID:22687989

NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275

G

matrix metallopeptidase 14

multiple interactions

EXP

Omeprazole inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893

G

matrix metallopeptidase 2

multiple interactions

EXP

Omeprazole inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

methylmalonyl-CoA mutase

affects expression

EXP

Omeprazole affects the expression of MMUT mRNA

NCBI chr 9:27,425,935...27,454,202
Ensembl chr 9:27,425,935...27,454,342

G

myeloperoxidase

multiple interactions
decreases activity

ISO
EXP

Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Acids results in increased activity of MPO protein]
Omeprazole results in decreased activity of MPO protein
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Cysteamine results in increased expression of MPO protein]; Omeprazole inhibits the reaction [Ethanol results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein]

PMID:16091555 PMID:17151854 PMID:20165931 PMID:25637687 PMID:27780710 More...

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

maestro

affects expression

EXP

Omeprazole affects the expression of MRO mRNA

NCBI chr18:69,723,764...69,742,815
Ensembl chr18:69,725,798...69,743,031

G

mitochondrial ribosomal protein L2

affects expression

EXP

Omeprazole affects the expression of MRPL2 mRNA

NCBI chr 9:21,830,834...21,834,607
Ensembl chr 9:21,830,835...21,834,641

G

mitochondrial ribosomal protein L9

affects expression

EXP

Omeprazole affects the expression of MRPL9 mRNA

NCBI chr 2:184,768,837...184,775,787
Ensembl chr 2:184,763,529...184,775,777

G

murinoglobulin 2

affects expression

EXP

Omeprazole affects the expression of PZP mRNA

NCBI chr 4:156,836,140...156,908,972

G

myeloid-associated differentiation marker

affects expression

EXP

Omeprazole affects the expression of MYADM mRNA

NCBI chr 1:74,779,616...74,796,752
Ensembl chr 1:74,775,698...74,789,710

G

MYC binding protein 2

affects expression

EXP

Omeprazole affects the expression of MYCBP2 mRNA

NCBI chr15:86,352,061...86,590,126
Ensembl chr15:86,352,061...86,590,325

G

myosin ID

affects expression

EXP

Omeprazole affects the expression of MYO1D mRNA

NCBI chr10:65,986,900...66,263,538
Ensembl chr10:65,975,122...66,263,958

G

N(alpha)-acetyltransferase 38, NatC auxiliary subunit

affects expression

EXP

Omeprazole affects the expression of NAA38 mRNA

NCBI chr10:54,588,304...54,617,715
Ensembl chr10:54,592,990...54,617,715

G

nucleosome assembly protein 1-like 1

affects expression

EXP

Omeprazole affects the expression of NAP1L1 mRNA

NCBI chr 7:48,819,464...48,844,108
Ensembl chr 7:48,819,477...48,844,104

G

N-acetyltransferase 8

affects expression

EXP

Omeprazole affects the expression of NAT8 mRNA

NCBI chr 4:119,836,986...119,837,764
Ensembl chr 4:119,835,645...119,843,159

G

nuclear receptor coactivator 1

multiple interactions

ISO

Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]

NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924

G

NDRG family member 2

affects expression

EXP

Omeprazole affects the expression of NDRG2 mRNA

NCBI chr15:27,074,481...27,087,376
Ensembl chr15:27,074,481...27,083,125

G

NADH:ubiquinone oxidoreductase subunit S5

affects expression

EXP

Omeprazole affects the expression of NDUFS5 mRNA

NCBI chr 5:141,258,828...141,264,552
Ensembl chr 2:184,849,197...185,028,909
Ensembl chr 5:184,849,197...185,028,909
Ensembl chr14:184,849,197...185,028,909

G

NADH:ubiquinone oxidoreductase subunit V3

affects expression

EXP

Omeprazole affects the expression of NDUFV3 mRNA

NCBI chr20:9,613,786...9,622,941
Ensembl chr13:48,468,224...48,488,847
Ensembl chr20:48,468,224...48,488,847

G

neuraminidase 2

affects expression

EXP

Omeprazole affects the expression of NEU2 mRNA

NCBI chr 9:95,666,338...95,715,209
Ensembl chr 9:95,696,507...95,715,208

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

EXP

Omeprazole inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nuclear transcription factor, X-box binding 1

affects expression

EXP

Omeprazole affects the expression of NFX1 mRNA

NCBI chr 5:60,900,140...60,958,889
Ensembl chr 5:60,901,217...60,958,889

G

NIPA-like domain containing 2

affects expression

EXP

Omeprazole affects the expression of NIPAL2 mRNA

NCBI chr 7:67,659,628...67,771,105
Ensembl chr 7:67,659,628...67,769,959

G

nitrilase 1

affects expression

EXP

Omeprazole affects the expression of NIT1 mRNA

NCBI chr13:86,302,334...86,305,770
Ensembl chr13:86,298,387...86,305,770

G

NLR family, pyrin domain containing 3

multiple interactions

EXP

Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

NME/NM23 nucleoside diphosphate kinase 2

affects expression

EXP

Omeprazole affects the expression of NME2 mRNA

NCBI chr10:79,394,999...79,400,418
Ensembl chr20:11,179,066...11,179,497
Ensembl chr10:11,179,066...11,179,497

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

EXP
ISO

Omeprazole results in increased expression of NQO1 mRNA
Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 mRNA]; Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 protein]
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA

PMID:17202759 PMID:22687989 PMID:26272953

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

ISO
EXP

[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]

PMID:12695340 PMID:17041008 PMID:25680588 PMID:26187274 PMID:27732639

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

affects expression
decreases metabolic processing
increases expression

EXP
ISO

Omeprazole affects the expression of NR1I3 mRNA
NR1I3 gene mutant form results in decreased metabolism of Omeprazole
Omeprazole results in increased expression of NR1I3 mRNA

PMID:19118567 PMID:19483382 PMID:27434302

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

nuclear receptor subfamily 3, group C, member 1

affects expression

EXP

Omeprazole affects the expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

out at first homolog

affects expression

EXP

Omeprazole affects the expression of OAF mRNA

NCBI chr 8:52,491,314...52,509,285
Ensembl chr 8:52,491,315...52,509,285

G

alpha-2u globulin PGCL4

affects expression

EXP

Omeprazole affects the expression of OBP3 mRNA

NCBI chr 5:79,637,234...79,640,810
Ensembl chr 5:79,637,234...79,640,675

G

oxoglutarate dehydrogenase

affects expression

EXP

Omeprazole affects the expression of OGDH mRNA

NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271

G

olfactory receptor 59

affects expression

EXP

Omeprazole affects the expression of OLR59 mRNA

NCBI chr 1:166,604,972...166,639,634
Ensembl chr 1:166,604,141...166,623,265

G

oligosaccharyltransferase complex non-catalytic subunit

affects expression

EXP

Omeprazole affects the expression of OSTC mRNA

NCBI chr 2:221,924,727...221,940,253
Ensembl chr 2:221,874,948...221,940,267

G

ornithine transcarbamylase

affects expression

EXP

Omeprazole affects the expression of OTC mRNA

NCBI chr X:15,126,358...15,202,473
Ensembl chr X:15,126,358...15,239,555

G

poly(A) binding protein, cytoplasmic 4

affects expression

EXP

Omeprazole affects the expression of PABPC4 mRNA

NCBI chr 5:140,847,835...140,864,089
Ensembl chr 5:140,848,225...140,864,087

G

phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

affects expression

EXP

Omeprazole affects the expression of PAICS mRNA

NCBI chr14:31,553,355...31,586,843
Ensembl chr14:31,553,357...31,587,027

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

Omeprazole results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

pyruvate carboxylase

affects expression

EXP

Omeprazole affects the expression of PCX mRNA

NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940

G

propionyl-CoA carboxylase subunit beta

affects expression

EXP

Omeprazole affects the expression of PCCB mRNA

NCBI chr 8:110,470,197...110,520,222
Ensembl chr 8:110,469,934...110,520,187

G

proliferating cell nuclear antigen

multiple interactions

EXP
ISO

[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; Omeprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein]
Omeprazole inhibits the reaction [Ethanol results in decreased expression of PCNA protein]

PMID:19251492 PMID:26970604

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

proprotein convertase subtilisin/kexin type 6

affects expression

EXP

Omeprazole affects the expression of PCSK6 mRNA

NCBI chr 1:128,839,742...129,038,087
Ensembl chr 1:128,839,232...129,052,128

G

phosphatidylcholine transfer protein

affects expression

EXP

Omeprazole affects the expression of PCTP mRNA

NCBI chr10:75,305,999...75,351,919
Ensembl chr10:75,305,999...75,326,432

G

phosducin-like 3

affects expression

EXP

Omeprazole affects the expression of PDCL3 mRNA

NCBI chr 9:48,730,083...48,738,554
Ensembl chr 9:48,723,767...48,739,529

G

protein disulfide isomerase family A, member 3

affects expression

EXP

Omeprazole affects the expression of PDIA3 mRNA

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

protein disulfide isomerase family A, member 6

affects expression

EXP

Omeprazole affects the expression of PDIA6 mRNA

NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:45,791,678...45,810,091

G

peroxisomal biogenesis factor 19

affects expression

EXP

Omeprazole affects the expression of PEX19 mRNA

NCBI chr13:87,124,654...87,141,170
Ensembl chr13:87,124,698...87,141,757

G

phosphoglycerate mutase 1

affects expression

EXP

Omeprazole affects the expression of PGAM1 mRNA

NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:250,673,049...250,690,203

G

progesterone receptor membrane component 1

affects expression

EXP

Omeprazole affects the expression of PGRMC1 mRNA

NCBI chr X:120,698,610...120,706,805
Ensembl chr X:120,698,610...120,706,805

G

phytanoyl-CoA 2-hydroxylase

affects expression

EXP

Omeprazole affects the expression of PHYH mRNA

NCBI chr17:78,238,747...78,255,645
Ensembl chr17:78,238,747...78,255,645

G

phosphatidylinositol glycan anchor biosynthesis, class P

affects expression

EXP

Omeprazole affects the expression of PIGP mRNA

NCBI chr11:47,152,601...47,158,766
Ensembl chr11:47,148,465...47,160,082

G

pyruvate kinase L/R

affects expression

EXP

Omeprazole affects the expression of PKLR mRNA

NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644

G

phospholipase A2 group 4A

increases phosphorylation
multiple interactions

ISO

Omeprazole results in increased phosphorylation of PLA2G4A protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Omeprazole results in increased phosphorylation of PLA2G4A protein]

NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641

G

phospholipase B domain containing 1

affects expression

EXP

Omeprazole affects the expression of PLBD1 mRNA

NCBI chr 4:171,204,198...171,260,488
Ensembl chr 4:171,204,198...171,260,488

G

plasminogen

affects expression

EXP

Omeprazole affects the expression of PLG mRNA

NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:50,872,926...50,917,320

G

plastin 3

affects expression

EXP

Omeprazole affects the expression of PLS3 mRNA

NCBI chr X:116,401,247...116,495,898
Ensembl chr X:116,401,293...116,495,893

G

paraoxonase 2

affects expression

EXP

Omeprazole affects the expression of PON2 mRNA

NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:34,356,274...34,391,996

G

POU class 2 homeobox 2

multiple interactions

EXP
ISO

Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein]

NCBI chr 1:89,810,153...89,897,560
Ensembl chr 1:89,812,093...89,897,564

G

pancreatic progenitor cell differentiation and proliferation factor

affects expression

EXP

Omeprazole affects the expression of PPDPF mRNA

NCBI chr 3:188,676,821...188,678,599
Ensembl chr 3:188,676,965...188,678,599

G

peroxiredoxin 2

affects expression

EXP

Omeprazole affects the expression of PRDX2 mRNA

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

peroxiredoxin 6

affects expression

EXP

Omeprazole affects the expression of PRDX6 mRNA

NCBI chr13:76,062,082...76,072,631
Ensembl chr13:76,061,554...76,072,657

G

prolactin

increases expression

ISO

Omeprazole results in increased expression of PRL protein

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

protein C, inactivator of coagulation factors Va and VIIIa

affects expression

EXP

Omeprazole affects the expression of PROC mRNA

NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964

G

phosphoribosyl pyrophosphate synthetase-associated protein 1

affects expression

EXP

Omeprazole affects the expression of PRPSAP1 mRNA

NCBI chr10:102,199,949...102,221,642
Ensembl chr10:102,199,950...102,221,642

G

proteasome 20S subunit alpha 6

affects expression

EXP

Omeprazole affects the expression of PSMA6 mRNA

NCBI chr 6:78,500,676...78,531,693
Ensembl chr 6:78,500,736...78,531,717

G

proteasome 20S subunit beta 1

affects expression

EXP

Omeprazole affects the expression of PSMB1 mRNA

NCBI chr 1:65,115,770...65,136,516
Ensembl chr 1:65,114,724...65,136,640

G

proteasome 20S subunit beta 3

affects expression

EXP

Omeprazole affects the expression of PSMB3 mRNA

NCBI chr10:83,193,787...83,200,883
Ensembl chr10:83,193,787...83,200,883

G

proteasome 26S subunit, ATPase 1

affects expression

EXP

Omeprazole affects the expression of PSMC1 mRNA

NCBI chr 6:125,122,497...125,134,859
Ensembl chr 6:125,122,490...125,134,858

G

proteasome 26S subunit, ATPase 3

affects expression

EXP

Omeprazole affects the expression of PSMC3 mRNA

NCBI chr 3:97,487,643...97,493,025
Ensembl chr 3:97,487,632...97,499,176

G

proteasome 26S subunit, ATPase 5

affects expression

EXP

Omeprazole affects the expression of PSMC5 mRNA

NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921

G

proteasome 26S subunit, non-ATPase 1

affects expression

EXP

Omeprazole affects the expression of PSMD1 mRNA

NCBI chr 9:94,157,971...94,233,218
Ensembl chr 9:94,157,971...94,233,218

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 4

affects expression

EXP

Omeprazole affects the expression of PSMD4 mRNA

NCBI chr 2:185,287,941...185,297,238
Ensembl chr 2:185,286,868...185,297,201

G

prostaglandin-endoperoxide synthase 2

multiple interactions

EXP
ISO

[Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA; [Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein
Omeprazole inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]

PMID:23038005 PMID:26970604

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

parathymosin

affects expression

EXP

Omeprazole affects the expression of PTMS mRNA

NCBI chr 4:159,408,647...159,412,837
Ensembl chr 4:159,408,649...159,415,212

G

protein tyrosine phosphatase, receptor type, F

affects expression

EXP

Omeprazole affects the expression of PTPRF mRNA

NCBI chr 5:137,027,376...137,109,405
Ensembl chr 5:137,028,164...137,095,426

G

PTTG1 interacting protein

affects expression

EXP

Omeprazole affects the expression of PTTG1IP mRNA

NCBI chr20:11,029,608...11,047,395
Ensembl chr20:11,029,608...11,046,909

G

glycogen phosphorylase L

affects expression

EXP

Omeprazole affects the expression of PYGL mRNA

NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:94,426,346...94,476,269

G

RAB5 interacting factor

affects expression

EXP

Omeprazole affects the expression of RAB5IF mRNA

NCBI chr 3:165,818,060...165,828,071
Ensembl chr 3:165,816,588...165,828,067

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP
ISO

[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of RELA protein]; Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
Omeprazole inhibits the reaction [Cisplatin affects the localization of RELA protein]

PMID:19251492 PMID:30452898 PMID:32418911

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

retinol saturase

increases expression

EXP

Omeprazole results in increased expression of RETSAT mRNA

NCBI chr 4:106,211,459...106,220,222
Ensembl chr 4:106,211,436...106,229,552

G

reactive intermediate imine deaminase A homolog

affects expression

EXP

Omeprazole affects the expression of RIDA mRNA

NCBI chr 7:67,576,586...67,590,493
Ensembl chr 7:67,576,586...67,590,692

G

ribonuclease A family member 4

affects expression

EXP

Omeprazole affects the expression of RNASE4 mRNA

NCBI chr15:26,786,287...26,803,634
Ensembl chr15:26,786,079...26,803,639

G

ring finger protein 103

affects expression

EXP

Omeprazole affects the expression of RNF103 mRNA

NCBI chr 4:105,084,762...105,100,839
Ensembl chr 4:105,084,686...105,106,809

G

RNA binding protein with serine rich domain 1

affects expression

EXP

Omeprazole affects the expression of RNPS1 mRNA

NCBI chr10:13,950,151...13,960,396
Ensembl chr10:13,950,184...13,960,393

G

ribosomal protein L11

affects expression

EXP

Omeprazole affects the expression of RPL11 mRNA

NCBI chr 5:153,557,592...153,561,230
Ensembl chr 5:153,557,597...153,561,127

G

ribosomal protein L13

affects expression

EXP

Omeprazole affects the expression of RPL13 mRNA

NCBI chr19:68,062,442...68,065,065
Ensembl chr19:68,062,493...68,065,059

G

ribosomal protein L15

affects expression

EXP

Omeprazole affects the expression of RPL15 mRNA

NCBI chr15:9,934,663...9,937,946
Ensembl chr15:9,934,679...9,938,308

G

ribosomal protein L17

affects expression

EXP

Omeprazole affects the expression of RPL17 mRNA

NCBI chr18:70,856,275...70,859,388
Ensembl chr 3:111,722,010...111,722,638
Ensembl chr18:111,722,010...111,722,638

G

ribosomal protein L23

affects expression

EXP

Omeprazole affects the expression of RPL23 mRNA

NCBI chr10:83,268,223...83,272,184
Ensembl chr10:83,262,592...83,272,214

G

ribosomal protein L3

affects expression

EXP

Omeprazole affects the expression of RPL3 mRNA

NCBI chr 7:113,491,943...113,508,115
Ensembl chr 7:113,501,960...113,507,990

G

ribosomal protein L32

affects expression

EXP

Omeprazole affects the expression of RPL32 mRNA

NCBI chr 4:150,536,650...150,540,214
Ensembl chr 4:150,536,646...150,540,214

G

ribosomal protein L4

affects expression

EXP

Omeprazole affects the expression of RPL4 mRNA

NCBI chr 8:73,566,477...73,571,600
Ensembl chr 8:73,566,466...73,571,788

G

ribophorin II

affects expression

EXP

Omeprazole affects the expression of RPN2 mRNA

NCBI chr 3:166,361,955...166,409,272
Ensembl chr 3:166,362,049...166,409,922

G

ribosomal protein S14

affects expression

EXP

Omeprazole affects the expression of RPS14 mRNA

NCBI chr18:56,492,010...56,503,092
Ensembl chr18:56,498,245...56,503,091

G

ribosomal protein S18

affects expression

EXP

Omeprazole affects the expression of RPS18 mRNA

NCBI chr20:4,933,741...4,937,423
Ensembl chr20:4,917,095...4,937,423

G

ribosomal protein S19

affects expression

EXP

Omeprazole affects the expression of RPS19 mRNA

NCBI chr 1:89,608,408...89,614,390
Ensembl chr 7:104,324,520...104,325,132
Ensembl chr 1:104,324,520...104,325,132

G

ribosomal protein S20

affects expression

EXP

Omeprazole affects the expression of RPS20 mRNA

NCBI chr 5:21,616,687...21,618,068
Ensembl chr 3:42,839,965...43,095,621
Ensembl chr 9:42,839,965...43,095,621
Ensembl chr 5:42,839,965...43,095,621

G

ribosomal protein S3a

affects expression

EXP

Omeprazole affects the expression of RPS3A mRNA

NCBI chr 2:173,822,673...173,827,042
Ensembl chr 2:173,822,488...173,827,043

G

ribosomal protein S6

affects expression

EXP

Omeprazole affects the expression of RPS6 mRNA

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566

G

ribosomal protein S8

affects expression

EXP

Omeprazole affects the expression of RPS8 mRNA

NCBI chr 5:135,866,941...135,869,511
Ensembl chr 5:135,866,941...135,869,548

G

RAS related 2

affects expression

EXP

Omeprazole affects the expression of RRAS2 mRNA

NCBI chr 1:177,668,143...177,737,551
Ensembl chr 1:177,668,144...177,737,551

G

RT1 class II, locus DMa

affects expression

ISO

Omeprazole affects the expression of HLA-DMA mRNA

NCBI chr20:4,708,932...4,712,335
Ensembl chr20:4,708,933...4,712,335

G

RT1 class Ib, locus M3, gene 1

affects expression

ISO

Omeprazole affects the expression of HLA-G mRNA

NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,329,225...1,333,366

G

RT1 class Ib, locus S3

affects expression

EXP

Omeprazole affects the expression of RT1-S3 mRNA

NCBI chr20:2,675,463...2,680,229

G

sphingosine-1-phosphate receptor 1

affects expression

EXP

Omeprazole affects the expression of S1PR1 mRNA

NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:205,900,836...206,328,689

G

somatomedin B and thrombospondin, type 1 domain containing

affects expression

EXP

Omeprazole affects the expression of SBSPON mRNA

NCBI chr 5:8,186,004...8,216,576
Ensembl chr 5:8,185,985...8,218,898

G

syndecan 2

affects expression

EXP

Omeprazole affects the expression of SDC2 mRNA

NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:66,108,853...66,126,294

G

succinate dehydrogenase complex subunit C

affects expression

EXP

Omeprazole affects the expression of SDHC mRNA

NCBI chr13:86,077,133...86,098,025
Ensembl chr13:86,077,134...86,098,044

G

succinate dehydrogenase complex subunit D

affects expression

EXP

Omeprazole affects the expression of SDHD mRNA

NCBI chr 8:59,841,090...59,850,641
Ensembl chr 8:59,841,090...59,850,641

G

selectin L

decreases expression

EXP

Omeprazole results in decreased expression of SELL protein

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600

G

serine incorporator 3

affects expression

EXP

Omeprazole affects the expression of SERINC3 mRNA

NCBI chr 3:172,721,208...172,749,853
Ensembl chr 3:172,721,321...172,740,765

G

serpin family A member 1

affects expression

EXP

Omeprazole affects the expression of SERPINA1 mRNA

NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:128,619,382...128,660,703

G

serpin family A member 10

affects expression

EXP

Omeprazole affects the expression of SERPINA10 mRNA

NCBI chr 6:128,520,894...128,529,332
Ensembl chr 6:128,520,896...128,529,332

G

serpin family A member 4

affects expression

EXP

Omeprazole affects the expression of SERPINA4 mRNA

NCBI chr 6:128,764,738...128,773,858
Ensembl chr 6:128,764,769...128,776,028

G

serpin family F member 2

affects expression

EXP

Omeprazole affects the expression of SERPINF2 mRNA

NCBI chr10:60,770,698...60,778,782
Ensembl chr10:60,770,698...60,778,996

G

serpin family G member 1

decreases expression

EXP

Omeprazole results in decreased expression of SERPING1 mRNA

NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:90,249,423...90,258,717

G

sideroflexin 1

affects expression

EXP

Omeprazole affects the expression of SFXN1 mRNA

NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,491,344...10,527,456

G

serine hydroxymethyltransferase 2

affects expression

EXP

Omeprazole affects the expression of SHMT2 mRNA

NCBI chr 7:65,244,247...65,249,580
Ensembl chr 7:65,244,247...65,249,567

G

solute carrier family 22 member 1

affects expression

EXP

Omeprazole affects the expression of SLC22A1 mRNA

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

multiple interactions

ISO

Omeprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 5

multiple interactions

EXP

Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]; Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 22 member 8

multiple interactions

ISO

[Omeprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

solute carrier family 23 member 1

affects expression

EXP

Omeprazole affects the expression of SLC23A1 mRNA

NCBI chr18:27,490,549...27,504,563
Ensembl chr18:27,490,374...27,504,702

G

solute carrier family 25 member 13

affects expression

EXP

Omeprazole affects the expression of SLC25A13 mRNA

NCBI chr 4:35,145,721...35,328,403
Ensembl chr 4:35,145,721...35,328,360

G

solute carrier family 25 member 3

affects expression

EXP

Omeprazole affects the expression of SLC25A3 mRNA

NCBI chr 7:27,499,164...27,506,685
Ensembl chr 7:27,499,165...27,506,309

G

solute carrier family 27 member 2

affects expression

EXP

Omeprazole affects the expression of SLC27A2 mRNA

NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581

G

solute carrier family 39 member 8

affects expression

EXP

Omeprazole affects the expression of SLC39A8 mRNA

NCBI chr 2:226,845,686...226,992,668
Ensembl chr 2:226,929,644...226,992,667

G

solute carrier family 40 member 1

decreases expression

ISO

Omeprazole results in decreased expression of SLC40A1 protein

NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:55,525,532...55,543,460

G

solute carrier family 46 member 1

affects expression

EXP

Omeprazole affects the expression of SLC46A1 mRNA

NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,859,504...63,866,869

G

solute carrier family 66 member 2

affects expression

EXP

Omeprazole affects the expression of SLC66A2 mRNA

NCBI chr18:75,976,000...76,014,651
Ensembl chr18:75,977,458...76,014,651

G

solute carrier family 6 member 6

affects expression

EXP

Omeprazole affects the expression of SLC6A6 mRNA

NCBI chr 4:125,752,340...125,826,033
Ensembl chr 4:125,752,372...125,826,032

G

solute carrier organic anion transporter family, member 1a1

affects expression

EXP

Omeprazole affects the expression of SLCO1A1 mRNA

NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992

G

solute carrier organic anion transporter family, member 1a4

increases expression

ISO

Omeprazole results in increased expression of SLCO1A2 mRNA

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816

G

superoxide dismutase 1

multiple interactions

ISO

Omeprazole inhibits the reaction [Ethanol results in decreased activity of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

signal peptide peptidase-like 2A

affects expression

EXP

Omeprazole affects the expression of SPPL2A mRNA

NCBI chr 3:134,602,684...134,646,752
Ensembl chr 3:134,605,750...134,646,752

G

spermidine synthase

affects expression

EXP

Omeprazole affects the expression of SRM mRNA

NCBI chr 5:164,309,002...164,312,203
Ensembl chr 5:164,308,991...164,332,705

G

SRP receptor subunit beta

affects expression

EXP

Omeprazole affects the expression of SRPRB mRNA

NCBI chr 8:112,647,577...112,661,524

G

SSX family member 2 interacting protein

affects expression

EXP

Omeprazole affects the expression of SSX2IP mRNA

NCBI chr 2:237,958,286...237,991,026
Ensembl chr 2:237,958,465...237,991,017

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

affects expression

EXP

Omeprazole affects the expression of ST3GAL6 mRNA

NCBI chr11:55,530,120...55,590,950
Ensembl chr11:55,530,248...55,598,720

G

ST6 beta-galactoside alpha-2,6-sialyltransferase 1

affects expression

EXP

Omeprazole affects the expression of ST6GAL1 mRNA

NCBI chr11:91,031,481...91,158,111
Ensembl chr11:91,032,450...91,040,415

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

affects expression

EXP

Omeprazole affects the expression of SUCLG1 mRNA

NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:106,866,114...106,895,689

G

surfeit 4

affects expression

EXP

Omeprazole affects the expression of SURF4 mRNA

NCBI chr 3:30,646,435...30,659,641
Ensembl chr 3:30,638,299...30,661,390

G

synaptojanin 2 binding protein

affects expression

EXP

Omeprazole affects the expression of SYNJ2BP mRNA

NCBI chr 6:106,920,970...106,958,653
Ensembl chr 6:106,920,970...106,966,543

G

tachykinin receptor 1

multiple interactions

ISO

Omeprazole inhibits the reaction [Acids affects the localization of TACR1 protein]

NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:116,478,617...116,647,492

G

transforming growth factor, beta 1

increases expression

ISO

Omeprazole results in increased expression of TGFB1 protein

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta induced

affects expression

EXP

Omeprazole affects the expression of TGFBI mRNA

NCBI chr17:7,960,885...7,990,234
Ensembl chr17:7,960,516...7,990,471

G

threonine synthase-like 2

affects expression

EXP

Omeprazole affects the expression of THNSL2 mRNA

NCBI chr 4:104,671,305...104,691,084
Ensembl chr 4:104,670,925...104,691,959

G

translocase of inner mitochondrial membrane 21

affects expression

EXP

Omeprazole affects the expression of TIMM21 mRNA

NCBI chr18:80,589,775...80,594,237
Ensembl chr18:80,589,783...80,594,237

G

TIMP metallopeptidase inhibitor 2

multiple interactions

EXP

Omeprazole inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

triokinase and FMN cyclase

affects expression

EXP

Omeprazole affects the expression of TKFC mRNA

NCBI chr 1:216,664,446...216,677,815
Ensembl chr 1:216,661,477...216,677,928

G

toll-like receptor 4

multiple interactions

EXP

Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

transmembrane BAX inhibitor motif containing 1

affects expression

EXP

Omeprazole affects the expression of TMBIM1 mRNA

NCBI chr 9:83,320,972...83,338,469
Ensembl chr 9:83,320,979...83,338,657

G

transmembrane BAX inhibitor motif containing 6

affects expression

EXP

Omeprazole affects the expression of TMBIM6 mRNA

NCBI chr 7:132,405,217...132,422,492
Ensembl chr 7:132,386,134...132,422,492

G

transmembrane and coiled-coil domains 1

affects expression

EXP

Omeprazole affects the expression of TMCO1 mRNA

NCBI chr13:81,993,172...82,016,496
Ensembl chr13:81,993,097...82,017,201

G

transmembrane p24 trafficking protein 2

affects expression

EXP

Omeprazole affects the expression of TMED2 mRNA

NCBI chr12:37,713,522...37,722,606
Ensembl chr12:37,713,529...37,722,606

G

transmembrane p24 trafficking protein 7

affects expression

EXP

Omeprazole affects the expression of TMED7 mRNA

NCBI chr18:41,505,167...41,512,243
Ensembl chr18:41,478,539...41,512,243

G

transmembrane protein 123

affects expression

EXP

Omeprazole affects the expression of TMEM123 mRNA

NCBI chr 8:13,206,907...13,237,069
Ensembl chr 8:13,206,403...13,257,427

G

transmembrane protein 97

affects expression

EXP

Omeprazole affects the expression of TMEM97 mRNA

NCBI chr10:63,936,276...63,945,359
Ensembl chr10:63,936,271...63,945,818

G

transmembrane serine protease 2

increases expression

EXP

Omeprazole results in increased expression of TMPRSS2 mRNA

NCBI chr11:50,403,707...50,443,224
Ensembl chr11:50,398,349...50,443,114

G

tumor necrosis factor

multiple interactions

ISO
EXP

Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]
Omeprazole inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]

PMID:19232345 PMID:25637687 PMID:26970604 PMID:30452898 PMID:32418911 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

thioredoxin 1

affects expression

EXP

Omeprazole affects the expression of TXN1 mRNA

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin-like 1

affects expression

EXP

Omeprazole affects the expression of TXNL1 mRNA

NCBI chr18:59,397,275...59,428,072
Ensembl chr18:59,398,535...59,435,518

G

tyrosinase

multiple interactions
decreases expression

ISO

Omeprazole affects the N-linked glycosylation of and results in increased degradation of TYR protein; Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole results in decreased expression of TYR protein

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

ubiquitin A-52 residue ribosomal protein fusion product 1

affects expression

EXP

Omeprazole affects the expression of UBA52 mRNA

NCBI chr16:18,952,583...18,954,780

G

ubiquitin-conjugating enzyme E2N

affects expression

EXP

Omeprazole affects the expression of UBE2N mRNA

NCBI chr 7:32,041,190...32,071,252

G

ubiquitin recognition factor in ER associated degradation 1

affects expression

EXP

Omeprazole affects the expression of UFD1 mRNA

NCBI chr11:95,665,971...95,689,423
Ensembl chr11:95,665,972...95,689,434

G

UDP glucuronosyltransferase family 1 member A1

increases expression
affects expression

ISO
EXP

Omeprazole results in increased expression of UGT1A1 mRNA
Omeprazole affects the expression of UGT1A1 mRNA

PMID:19118567 PMID:19483382 PMID:25626140

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

ISO

Omeprazole results in increased expression of UGT1A2 mRNA; Omeprazole results in increased expression of UGT1A3 mRNA

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glycosyltransferase 1 family, polypeptide A3

increases expression

ISO

Omeprazole results in increased expression of UGT1A5 mRNA

NCBI chr 9:96,228,134...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A5

increases expression

ISO

Omeprazole results in increased expression of UGT1A4 mRNA

NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A6a

increases expression
multiple interactions

EXP
ISO

Omeprazole results in increased expression of UGT1A6 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA

PMID:19118567 PMID:22687989

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases expression

ISO

Omeprazole results in increased expression of UGT1A9 mRNA

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases expression

EXP

Omeprazole results in increased expression of UGT2B1 mRNA

NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331

G

ubiquinol-cytochrome c reductase, complex III subunit XI

affects expression

EXP

Omeprazole affects the expression of UQCR11 mRNA

NCBI chr 7:9,955,717...9,960,432
Ensembl chr 7:9,955,764...9,959,047

G

vanin 1

affects expression

EXP

Omeprazole affects the expression of VNN1 mRNA

NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:23,356,330...23,366,629

G

WD repeat domain 26

affects expression

EXP

Omeprazole affects the expression of WDR26 mRNA

NCBI chr13:95,462,017...95,503,826
Ensembl chr13:95,462,020...95,503,738

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

affects expression

EXP

Omeprazole affects the expression of YWHAG mRNA

NCBI chr12:26,381,106...26,409,466
Ensembl chr12:26,380,816...26,409,465

G

zinc finger DHHC-type palmitoyltransferase 23

affects expression

EXP

Omeprazole affects the expression of ZDHHC23 mRNA

NCBI chr11:70,224,581...70,240,971
Ensembl chr11:70,225,045...70,240,102

G

ZW10 interacting kinetochore protein

affects expression

EXP

Omeprazole affects the expression of ZWINT mRNA

NCBI chr20:15,502,559...15,953,701
Ensembl chr20:15,937,396...15,953,203

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glial cell derived neurotrophic factor

multiple interactions
increases expression

ISO

Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein]
rasagiline results in increased expression of GDNF mRNA; rasagiline results in increased expression of GDNF protein

NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240

G

monoamine oxidase B

decreases activity

ISO

rasagiline results in decreased activity of MAOB protein

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

rasagiline results in increased localization of and results in increased activity of RELA protein; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

monoamine oxidase A

decreases activity

EXP

toloxatone results in decreased activity of MAOA protein

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

tranylcypromine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activity-regulated cytoskeleton-associated protein

increases expression

EXP

Tranylcypromine results in increased expression of ARC mRNA

NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

EXP

Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

brain-derived neurotrophic factor

increases expression

EXP

Tranylcypromine results in increased expression of BDNF mRNA

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

caspase 3

multiple interactions

EXP

Tranylcypromine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

cAMP responsive element binding protein 1

increases expression

EXP

Tranylcypromine results in increased expression of CREB1 mRNA

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity

EXP

Tranylcypromine results in increased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity

ISO

Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
Tranylcypromine results in decreased activity of CYP1A2 protein

PMID:15916432 PMID:24120545

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily a, polypeptide 1

multiple interactions

ISO

Tranylcypromine inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]

NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
decreases activity

ISO

Tranylcypromine inhibits the reaction [[CYP2B6 protein results in increased metabolism of 7-ethoxy-4-trifluoromethylcoumarin] which results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]; Tranylcypromine inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]
Tranylcypromine results in decreased activity of CYP2B6 protein

PMID:23850985 PMID:28119166

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
decreases activity

ISO

Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Tranylcypromine inhibits the reaction [[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein]; Tranylcypromine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
Tranylcypromine results in decreased activity of CYP2C19 protein

PMID:12569440 PMID:15306208 PMID:23850985 PMID:24120545 PMID:28119166

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily c, polypeptide 79

multiple interactions

ISO

Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

ISO

Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

ISO

Tranylcypromine results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 2, subfamily j, polypeptide 4

decreases activity

ISO

Tranylcypromine results in decreased activity of CYP2J2 protein

NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

ISO

Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

early growth response 1

decreases expression

EXP

Tranylcypromine results in decreased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

Tranylcypromine results in decreased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

glutamic--pyruvic transaminase

multiple interactions

ISO

Tranylcypromine inhibits the reaction [[Methimazole co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

heme oxygenase 1

multiple interactions

EXP

Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

neurotrophic receptor tyrosine kinase 2

increases expression

EXP

Tranylcypromine results in increased expression of NTRK2 mRNA

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628

G

cytochrome p450 oxidoreductase

multiple interactions

ISO

Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

trace-amine-associated receptor 1

increases activity
multiple interactions

ISO

Tranylcypromine results in increased activity of TAAR1 protein
[Tranylcypromine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP

NCBI chr 1:23,336,978...23,337,976
Ensembl chr 1:23,335,165...23,353,981

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
role	20844
biological role	20831
biochemical role	19888
enzyme inhibitor	18710
EC 1.* (oxidoreductase) inhibitor	17657
EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor	1444
EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor	1444
EC 1.4.3.2 (L-amino-acid oxidase) inhibitor +	0
EC 1.4.3.22 (diamine oxidase) inhibitor +	0
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor +	426
EC 1.4.3.4 (monoamine oxidase) inhibitor +	1100

paths to the root