EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	*EC 1.14.18. (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor**	go back to main search page
Accession:	CHEBI:76845	browse the term
Definition:	An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme using a miscellaneous compound as one donor and incorporating one atom of oxygen (EC 1.14.18.*).
Synonyms:	related_synonym:	EC 1.14.18.* inhibitor; EC 1.14.18.* inhibitors; oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen (EC 1.14.18.*) inhibitors

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Genes (915)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin D1

decreases expression

ISO

brazilein results in decreased expression of CCND1 mRNA; brazilein results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

catenin beta 1

decreases expression

ISO

brazilein results in decreased expression of CTNNB1 protein

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

glycogen synthase kinase 3 beta

decreases expression

ISO

brazilein results in decreased expression of GSK3B protein modified form

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

matrix metallopeptidase 2

multiple interactions
decreases expression

ISO

brazilein promotes the reaction [SB 203580 results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein promotes the reaction [wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein results in decreased expression of and results in decreased activity of MMP2 protein; SB 203580 promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]
brazilein results in decreased expression of MMP2 mRNA

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

NFKB inhibitor alpha

multiple interactions

ISO

brazilein results in decreased expression of and results in decreased phosphorylation of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

RELA proto-oncogene, NF-kB subunit

decreases expression

ISO

brazilein results in decreased expression of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

EXP

dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein]

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

decreases expression

ISO
EXP

dioscin results in decreased expression of ABCB1 mRNA; dioscin results in decreased expression of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 2

multiple interactions

EXP

dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein]

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

acyl-CoA dehydrogenase medium chain

multiple interactions

EXP
ISO

dioscin inhibits the reaction [Ethanol results in decreased expression of ACADM protein]

NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864

G

acyl-CoA dehydrogenase short chain

multiple interactions

ISO
EXP

dioscin inhibits the reaction [Ethanol results in decreased expression of ACADS protein]

NCBI chr12:47,154,259...47,163,580
Ensembl chr12:47,154,276...47,164,103

G

acyl-CoA oxidase 1

multiple interactions

EXP
ISO

dioscin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA]

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

acyl-CoA synthetase long-chain family member 1

multiple interactions

ISO
EXP

dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein]

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023

G

acyl-CoA synthetase long-chain family member 5

multiple interactions

ISO
EXP

dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein]

NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:264,294,864...264,341,943

G

actin alpha 2, smooth muscle

multiple interactions

ISO

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

AKT serine/threonine kinase 1

multiple interactions
decreases expression

ISO

dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]
dioscin results in decreased expression of AKT1 mRNA
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of AKT1 protein]

PMID:25111127 PMID:29990575 PMID:35481609

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

aldehyde dehydrogenase 7 family, member A1

multiple interactions

ISO
EXP

dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein]

NCBI chr18:52,208,035...52,240,293
Ensembl chr18:52,204,161...52,240,467

G

apoptotic peptidase activating factor 1

decreases expression

ISO

dioscin results in decreased expression of APAF1 mRNA

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

activating transcription factor 6

multiple interactions

EXP
ISO

dioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein]

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

BCL2-associated agonist of cell death

increases expression

ISO

dioscin results in increased expression of BAD mRNA

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2-antagonist/killer 1

multiple interactions
increases expression

ISO

dioscin inhibits the reaction [Acetaminophen results in increased expression of BAK1 protein]
dioscin results in increased expression of BAK1 mRNA; dioscin results in increased expression of BAK1 protein

PMID:22334414 PMID:22939915 PMID:29990575 PMID:33359023

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO

dioscin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
dioscin results in increased expression of BAX mRNA; dioscin results in increased expression of BAX protein

PMID:22334414 PMID:22939915 PMID:33359023

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bcl-2 binding component 3

increases expression

ISO

dioscin results in increased expression of BBC3 mRNA; dioscin results in increased expression of BBC3 protein

PMID:29990575 PMID:33359023

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

BCL2, apoptosis regulator

multiple interactions
decreases expression
increases expression

ISO

dioscin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]
dioscin results in decreased expression of BCL2 mRNA; dioscin results in decreased expression of BCL2 protein
dioscin results in increased expression of BCL2 protein

PMID:22334414 PMID:22939915 PMID:24742230 PMID:29990575 PMID:33359023

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression

ISO

dioscin results in decreased expression of BCL2L1 mRNA; dioscin results in decreased expression of BCL2L1 protein

PMID:22334414 PMID:29990575 PMID:33359023

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

BH3 interacting domain death agonist

multiple interactions
decreases expression

ISO

[Acetaminophen co-treated with dioscin] results in increased expression of BID protein
dioscin results in decreased expression of BID mRNA; dioscin results in decreased expression of BID protein

PMID:22334414 PMID:22939915

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

baculoviral IAP repeat-containing 5

increases expression

ISO

dioscin results in increased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

caspase 3

multiple interactions
increases activity
increases expression
decreases expression

EXP
ISO

dioscin inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
dioscin results in increased activity of CASP3 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]
dioscin results in increased expression of CASP3 mRNA; dioscin results in increased expression of CASP3 protein
dioscin results in decreased expression of CASP3 mRNA; dioscin results in decreased expression of CASP3 protein

PMID:22334414 PMID:24146112 PMID:29990575 PMID:33359023

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases expression

ISO

dioscin results in increased expression of CASP7 mRNA

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

increases activity
increases expression
decreases expression
multiple interactions

ISO

dioscin results in increased activity of CASP8 protein
dioscin results in increased expression of CASP8 mRNA; dioscin results in increased expression of CASP8 protein
dioscin results in decreased expression of CASP8 mRNA
dioscin results in decreased expression of and results in increased cleavage of CASP8 protein

PMID:22334414 PMID:29990575 PMID:33359023

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions
increases expression
decreases expression

EXP
ISO

dioscin inhibits the reaction [Ethanol results in increased expression of CASP9 protein]
dioscin results in increased expression of CASP9 mRNA; dioscin results in increased expression of CASP9 protein
dioscin results in decreased expression of CASP9 mRNA; dioscin results in decreased expression of CASP9 protein

PMID:24146112 PMID:29990575 PMID:33359023

Ensembl chr 5:159,391,188...159,409,648

G

cyclin A2

decreases expression

ISO

dioscin results in decreased expression of CCNA2 mRNA; dioscin results in decreased expression of CCNA2 protein

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

decreases expression

ISO

dioscin results in decreased expression of CCNB1 mRNA; dioscin results in decreased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

increases expression
decreases expression

ISO

dioscin results in increased expression of CCND1 mRNA
dioscin results in decreased expression of CCND1 mRNA; dioscin results in decreased expression of CCND1 protein

PMID:29990575 PMID:33359023

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin E1

decreases expression

ISO

dioscin results in decreased expression of CCNE1 mRNA; dioscin results in decreased expression of CCNE1 protein

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cyclin-dependent kinase 1

decreases expression

ISO

dioscin results in decreased expression of CDK1 mRNA; dioscin results in decreased expression of CDK1 protein

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin dependent kinase 2

decreases expression

ISO

dioscin results in decreased expression of CDK2 mRNA; dioscin results in decreased expression of CDK2 protein

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

decreases expression

ISO

dioscin results in decreased expression of CDK4 mRNA

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase 6

decreases expression

ISO

dioscin results in decreased expression of CDK6 mRNA; dioscin results in decreased expression of CDK6 protein

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

dioscin results in increased expression of CDKN1A mRNA; dioscin results in increased expression of CDKN1A protein

PMID:29990575 PMID:33359023

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

dioscin results in increased expression of CDKN1B mRNA; dioscin results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cyclin-dependent kinase inhibitor 2A

increases expression

ISO

dioscin results in increased expression of CDKN2A mRNA; dioscin results in increased expression of CDKN2A protein

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248

G

checkpoint kinase 1

decreases expression

ISO

dioscin results in decreased expression of CHEK1 mRNA; dioscin results in decreased expression of CHEK1 protein

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

checkpoint kinase 2

decreases expression

ISO

dioscin results in decreased expression of CHEK2 mRNA; dioscin results in decreased expression of CHEK2 protein

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

carnitine palmitoyltransferase 1A

multiple interactions

ISO
EXP

dioscin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

catenin beta 1

increases expression
multiple interactions

ISO

dioscin results in increased expression of CTNNB1 mRNA; dioscin results in increased expression of CTNNB1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of CTNNB1 mRNA]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cytochrome c, somatic

increases expression

ISO

dioscin results in increased expression of CYCS mRNA

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

ISO
EXP

dioscin inhibits the reaction [Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]

PMID:22939915 PMID:24146112

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

diacylglycerol O-acyltransferase 1

multiple interactions

ISO
EXP

dioscin inhibits the reaction [Ethanol results in increased expression of DGAT1 mRNA]

NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016

G

diacylglycerol O-acyltransferase 2

multiple interactions

ISO
EXP

dioscin inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA]

NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:162,866,237...162,896,566

G

diablo, IAP-binding mitochondrial protein

increases expression

ISO

dioscin results in increased expression of DIABLO mRNA

NCBI chr12:38,716,668...38,731,285
Ensembl chr12:38,716,668...38,731,265

G

estrogen receptor 1

increases expression
multiple interactions

ISO

dioscin results in increased expression of ESR1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of ESR1 protein]

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions
increases expression

ISO

fulvestrant inhibits the reaction [dioscin results in increased expression of ESR2 protein]

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

Fas associated via death domain

increases expression

ISO

dioscin results in increased expression of FADD mRNA; dioscin results in increased expression of FADD protein

PMID:22334414 PMID:29990575 PMID:33359023

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

Fas cell surface death receptor

increases expression

ISO

dioscin results in increased expression of FAS mRNA; dioscin results in increased expression of FAS protein

PMID:22334414 PMID:33359023

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

increases expression

ISO

dioscin results in increased expression of FASLG mRNA; dioscin results in increased expression of FASLG protein

PMID:22334414 PMID:29990575

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

forkhead box O1

increases expression

ISO

dioscin results in increased expression of FOXO1 mRNA

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

glutamic--pyruvic transaminase

multiple interactions

EXP

dioscin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione-disulfide reductase

multiple interactions

EXP
ISO

dioscin inhibits the reaction [Ethanol results in decreased expression of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

high mobility group box 1

multiple interactions

EXP

dioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein]
dioscin inhibited the reaction [thioacetamide increased expression of Hmgb1 protein in liver]

CTD
RGD

PMID:28082111 PMID:29091898

NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327

G

heme oxygenase 1

multiple interactions

EXP

dioscin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]
dioscin inhibited the reaction [thioacetamide decreased expression of Hmox1 protein in liver]

CTD
RGD

PMID:28082111 PMID:29091898

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family A (Hsp70) member 5

multiple interactions

EXP
ISO

dioscin inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

intercellular adhesion molecule 1

multiple interactions

EXP

dioscin inhibited the reaction [thioacetamide increased expression of Icam1 protein in liver]

RGD

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interleukin 13

multiple interactions

ISO

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL13 protein]

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 1 beta

multiple interactions

EXP

dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]
dioscin inhibited the reaction [thioacetamide increased expression of IL-1b mRNA in liver]

CTD
RGD

PMID:28082111 PMID:29091898

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 4

multiple interactions

ISO

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 5

multiple interactions

ISO

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein]

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

interleukin 6

multiple interactions

ISO
EXP

dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]
dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]
dioscin inhibited the reaction [thioacetamide increased expression of IL-6 mRNA in liver]

CTD
RGD

PMID:24146112 PMID:28082111 PMID:29091898

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

kinase insert domain receptor

multiple interactions

ISO

dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

Kelch-like ECH-associated protein 1

multiple interactions

EXP

dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein]

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

keratin 18

multiple interactions

ISO
EXP

dioscin inhibits the reaction [Acetaminophen results in increased expression of KRT18 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of KRT18 protein]

PMID:22939915 PMID:24146112

NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:135,035,982...135,039,848
Ensembl chr10:135,035,982...135,039,848

G

LDL receptor related protein 5

multiple interactions
increases expression

ISO

fulvestrant inhibits the reaction [dioscin results in increased expression of LRP5 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA]

NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:210,243,502...210,346,822

G

mitogen activated protein kinase 1

multiple interactions

EXP
ISO

dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]

PMID:24146112 PMID:25111127

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

EXP
ISO

dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]

PMID:24146112 PMID:25111127

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

increases expression

ISO

dioscin results in increased expression of MAPK8 mRNA

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

increases expression

ISO

dioscin results in increased expression of MAPK9 mRNA

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

malate dehydrogenase 1

multiple interactions

ISO

dioscin inhibits the reaction [Acetaminophen results in decreased expression of MDH1 protein]

NCBI chr14:99,831,934...99,847,227
Ensembl chr14:99,831,615...99,847,232

G

mechanistic target of rapamycin kinase

decreases expression

ISO

dioscin results in decreased expression of MTOR mRNA

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

ISO

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of MUC5AC mRNA]

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006

G

NFE2 like bZIP transcription factor 2

multiple interactions

EXP

dioscin inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of NFE2L2 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nfe2L2 protein in liver]

CTD
RGD

PMID:28082111 PMID:29091898

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions

EXP

dioscin inhibited the reaction [thioacetamide increased expression of Nfkb1 protein in liver]

RGD

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

decreases degradation

ISO

dioscin results in decreased degradation of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

EXP

dioscin inhibited the reaction [thioacetamide decreased expression of Nqo1 protein in liver]

RGD

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions
increases expression

EXP

dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]
dioscin results in increased expression of NR0B2 mRNA

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

EXP

dioscin inhibits the reaction [Doxorubicin results in decreased expression of NR1H4 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nr1h4 protein in liver]

CTD
RGD

PMID:28082111 PMID:29091898

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases expression
decreases expression

ISO
EXP

dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein]
dioscin results in increased expression of PARP1 mRNA
dioscin results in decreased expression of PARP1 mRNA; dioscin results in decreased expression of PARP1 protein

PMID:24146112 PMID:29990575 PMID:33359023

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

decreases expression

ISO

dioscin results in decreased expression of PIK3CB mRNA

NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331

G

purine nucleoside phosphorylase

multiple interactions

ISO

dioscin inhibits the reaction [Acetaminophen results in decreased expression of PNP protein]

NCBI chr15:26,644,147...26,651,808
Ensembl chr15:26,643,858...26,678,162

G

peroxisome proliferator activated receptor alpha

multiple interactions

EXP
ISO

dioscin inhibits the reaction [Ethanol results in decreased expression of PPARA protein]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxiredoxin 1

multiple interactions

ISO

dioscin inhibits the reaction [Acetaminophen results in decreased expression of PRDX1 protein]

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

EXP

dioscin inhibited the reaction [thioacetamide decreased expression of Prkaa1 protein in liver]

RGD

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

protein kinase AMP-activated non-catalytic subunit beta 1

increases expression

ISO

dioscin results in increased expression of PRKAB1 mRNA

NCBI chr12:46,248,971...46,259,487
Ensembl chr12:46,249,010...46,259,482

G

prostaglandin-endoperoxide synthase 2

multiple interactions

EXP

dioscin inhibited the reaction [thioacetamide increased expression of Ptgs2 protein in liver]

RGD

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 2

multiple interactions

ISO

dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein]

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

regucalcin

multiple interactions

ISO

dioscin inhibits the reaction [Acetaminophen results in decreased expression of RGN protein]

NCBI chr X:4,172,537...4,190,112
Ensembl chr X:4,172,537...4,190,251

G

ribosomal protein S6 kinase B1

decreases expression

ISO

dioscin results in decreased expression of RPS6KB1 mRNA

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

solute carrier family 10 member 1

multiple interactions

EXP

dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]

NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944

G

solute carrier organic anion transporter family, member 1a1

increases expression
multiple interactions

EXP

dioscin results in increased expression of SLCO1A1 mRNA
dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1A1 mRNA]; dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1A1 protein]

NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992

G

solute carrier organic anion transporter family, member 1a4

increases expression

EXP

dioscin results in increased expression of SLCO1A2 mRNA

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816

G

solute carrier organic anion transporter family member 1B2

multiple interactions
increases expression

EXP

dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]; dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 protein]
dioscin results in increased expression of SLCO1B2 mRNA

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

ISO

dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein]

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

sulfite oxidase

multiple interactions

ISO

dioscin inhibits the reaction [Acetaminophen results in decreased expression of SUOX protein]

NCBI chr 7:1,687,666...1,691,759
Ensembl chr 7:1,687,666...1,690,235

G

transforming growth factor, beta 1

multiple interactions

ISO

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TGFB1 protein]
dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions
increases expression

ISO
EXP

dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]
dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]
dioscin results in increased expression of TNF mRNA; dioscin results in increased expression of TNF protein
dioscin inhibited the reaction [thioacetamide increased expression of Tnfa mRNA in liver]

CTD
RGD

PMID:22334414 PMID:24146112 PMID:28082111 PMID:29990575 PMID:33359023 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 11B

increases expression
multiple interactions

ISO

dioscin results in increased expression of TNFRSF11B mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF receptor superfamily member 1A

increases expression

ISO

dioscin results in increased expression of TNFRSF1A mRNA; dioscin results in increased expression of TNFRSF1A protein

PMID:22334414 PMID:29990575 PMID:33359023

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF receptor superfamily member 25

increases expression

ISO

dioscin results in increased expression of TNFRSF25 mRNA

PMID:29990575 PMID:33359023

NCBI chr 5:167,904,377...167,909,052
Ensembl chr 5:167,904,786...167,909,052

G

TNF superfamily member 11

decreases expression
multiple interactions

ISO

dioscin results in decreased expression of TNFSF11 mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFSF11 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA]

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

tumor protein p53

multiple interactions
increases expression

ISO
EXP

dioscin inhibits the reaction [Acetaminophen results in increased expression of TRP53 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TRP53 protein]
dioscin results in increased expression of TP53 mRNA; dioscin results in increased expression of TP53 protein

PMID:22334414 PMID:22939915 PMID:24146112 PMID:29990575

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

TNFRSF1A-associated via death domain

increases expression

ISO

dioscin results in increased expression of TRADD mRNA

PMID:29990575 PMID:33359023

NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550

G

TNF receptor-associated factor 1

increases expression

ISO

dioscin results in increased expression of TRAF1 protein

NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:38,619,506...38,636,264

G

vascular endothelial growth factor A

multiple interactions

ISO

dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

WEE1 G2 checkpoint kinase

increases expression

ISO

dioscin results in increased expression of WEE1 mRNA

NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acid phosphatase 3

increases expression

ISO

Ellagic Acid results in increased expression of ACP3 mRNA

NCBI chr 8:113,784,372...113,833,033
Ensembl chr 8:113,785,032...113,833,033

G

acid phosphatase 5, tartrate resistant

multiple interactions

ISO

Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]

NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929

G

angiotensinogen

multiple interactions

EXP

Ellagic Acid inhibits the reaction [AGT protein results in decreased abundance of NADP]; Ellagic Acid inhibits the reaction [AGT protein results in increased activity of CASP3 protein]; Ellagic Acid inhibits the reaction [AGT protein results in increased activity of RELA protein]; Ellagic Acid inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Ellagic Acid inhibits the reaction [AGT protein results in increased expression of CYBA mRNA]; Ellagic Acid inhibits the reaction [AGT protein results in increased expression of MYH7 mRNA]; Ellagic Acid inhibits the reaction [AGT protein results in increased expression of NCF2 mRNA]; Ellagic Acid inhibits the reaction [AGT protein results in increased expression of NOS2 mRNA]; Ellagic Acid inhibits the reaction [AGT protein results in increased expression of NPPA mRNA]; Ellagic Acid inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]; Ellagic Acid inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Ellagic Acid inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 1a

multiple interactions

EXP

Ellagic Acid inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

apoptosis inducing factor, mitochondria associated 1

increases expression

ISO

Ellagic Acid results in increased expression of AIFM1 protein

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

ISO
EXP

Ellagic Acid results in increased phosphorylation of AKT1 protein
Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 protein]

PMID:26986492 PMID:35236242

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

multiple interactions
affects binding

ISO

ALB protein promotes the reaction [Ellagic Acid results in increased activity of F12 protein]
Ellagic Acid binds to ALB protein

PMID:6343536 PMID:25247703

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase

decreases activity

ISO

Ellagic Acid results in decreased activity of ALKBH2 protein

NCBI chr12:48,156,825...48,161,489
Ensembl chr12:48,156,827...48,161,483

G

alkaline phosphatase, biomineralization associated

increases expression

ISO

Ellagic Acid results in increased expression of ALPL mRNA

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

apoptotic peptidase activating factor 1

decreases expression
increases expression

ISO

Ellagic Acid results in decreased expression of APAF1 mRNA
Ellagic Acid results in increased expression of APAF1 mRNA

PMID:12002526 PMID:35179410

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

amyloid beta precursor protein

multiple interactions

EXP

Ellagic Acid inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

achaete-scute family bHLH transcription factor 1

increases expression

ISO

Ellagic Acid results in increased expression of ASCL1 mRNA

NCBI chr 7:23,790,642...23,793,509
Ensembl chr 7:23,790,360...23,798,231

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

ISO

Ellagic Acid results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

activating transcription factor 3

increases expression

ISO

Ellagic Acid results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

autophagy related 5

increases expression

ISO

Ellagic Acid results in increased expression of ATG5 mRNA

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821

G

BCL2-associated agonist of cell death

increases expression

ISO

Ellagic Acid results in increased expression of BAD protein

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

EXP
ISO

Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of BAX mRNA]
Ellagic Acid results in increased expression of BAX mRNA

PMID:29854611 PMID:35179410

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

increases expression
decreases expression
multiple interactions

ISO
EXP

Ellagic Acid results in increased expression of BCL2 protein
Ellagic Acid results in decreased expression of BCL2 mRNA
Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2 protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in decreased expression of BCL2 mRNA]
[Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BCL2 mRNA]

PMID:20103723 PMID:22386815 PMID:29854611 PMID:35179410 PMID:35236242

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

bone morphogenetic protein 6

decreases expression

ISO

Ellagic Acid results in decreased expression of BMP6 mRNA

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

BRF1 general transcription factor IIIB subunit

decreases expression

ISO

Ellagic Acid results in decreased expression of BRF1 mRNA

NCBI chr 6:137,854,055...137,902,629
Ensembl chr 6:137,855,449...137,902,386

G

calreticulin

decreases expression

ISO

Ellagic Acid results in decreased expression of CALR mRNA

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236

G

caspase 3

increases expression
multiple interactions
increases activity
decreases activity
decreases expression

ISO
EXP

Ellagic Acid results in increased expression of CASP3 mRNA
Ellagic Acid inhibits the reaction [AGT protein results in increased activity of CASP3 protein]; Ellagic Acid inhibits the reaction [Aluminum Chloride results in increased expression of CASP3 protein]; Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of CASP3 protein]; Ellagic Acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased activity of CASP3 protein]; Ellagic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Ellagic Acid promotes the reaction [sinapinic acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]]; sinapinic acid promotes the reaction [Ellagic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]]
Ellagic Acid results in increased expression of and results in increased activity of CASP3 protein
Ellagic Acid results in increased activity of CASP3 protein
Ellagic Acid results in decreased activity of CASP3 protein
Ellagic Acid results in decreased expression of CASP3 mRNA

PMID:12002526 PMID:22386815 PMID:23554011 PMID:23811531 PMID:28815802 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

ISO

Ellagic Acid results in increased expression of and results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

catalase

increases activity
multiple interactions

EXP

Ellagic Acid results in increased activity of CAT protein
Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of CAT protein]; Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Ellagic Acid inhibits the reaction [chromium hexavalent ion results in decreased activity of CAT protein]; Ellagic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]

PMID:20074268 PMID:24877639 PMID:29864931 PMID:35236242 PMID:36108929

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

decreases secretion

ISO

Ellagic Acid results in decreased secretion of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin G1

decreases expression

EXP

ellagic acid inhibits the reaction [estrogen increases expression of Ccng1 mRNA and protein in rat mammary tissue]

RGD

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

CD14 molecule

decreases expression

ISO

Ellagic Acid results in decreased expression of CD14 mRNA

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292

G

cyclin-dependent kinase 1

decreases expression

ISO

Ellagic Acid results in decreased expression of CDK1 protein

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ISO

[resveratrol co-treated with Ellagic Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A mRNA]
[Ellagic Acid co-treated with Quercetin] results in increased expression of CDKN1A mRNA; Ellagic Acid promotes the reaction [Quercetin results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased expression of CDKN1A protein]]
Ellagic Acid results in increased expression of CDKN1A protein

PMID:15735102 PMID:20103723 PMID:23554011

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

collagen type I alpha 1 chain

increases expression

ISO

Ellagic Acid results in increased expression of COL1A1 mRNA; Ellagic Acid results in increased expression of COL1A1 protein

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

cathepsin D

multiple interactions

EXP

Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cathepsin K

multiple interactions

ISO

Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582

G

cytochrome b-245 alpha chain

multiple interactions

EXP

Ellagic Acid inhibits the reaction [AGT protein results in increased expression of CYBA mRNA]

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases expression
decreases activity

ISO

Ellagic Acid results in decreased expression of CYP1A1 mRNA
Ellagic Acid results in decreased activity of CYP1A1 protein

PMID:19329757 PMID:20816778

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity
multiple interactions

ISO

Ellagic Acid results in decreased activity of CYP1B1 protein
[Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; [Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]

PMID:19329757 PMID:20103723

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

death-domain associated protein

decreases expression

ISO

Ellagic Acid results in decreased expression of DAXX mRNA

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,971,941...4,977,720

G

DNA fragmentation factor subunit alpha

decreases expression

ISO

Ellagic Acid results in decreased expression of DFFA mRNA

NCBI chr 5:164,823,807...164,836,729
Ensembl chr 5:164,823,807...164,836,728

G

E4F transcription factor 1

increases expression

ISO

Ellagic Acid results in increased expression of E4F1 mRNA

NCBI chr10:13,978,975...13,999,646
Ensembl chr10:13,978,990...13,990,506

G

early growth response 3

decreases expression

ISO

Ellagic Acid results in decreased expression of EGR3 mRNA

NCBI chr15:51,560,482...51,565,778
Ensembl chr15:51,560,344...51,565,712

G

endonuclease G

increases expression

ISO

Ellagic Acid results in increased expression of ENDOG protein

NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573

G

E1A binding protein p300

increases expression

ISO

Ellagic Acid results in increased expression of EP300 mRNA

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

epidermal growth factor receptor pathway substrate 15

increases expression

ISO

Ellagic Acid results in increased expression of EPS15 mRNA

NCBI chr 5:129,274,487...129,374,856
Ensembl chr 5:129,274,502...129,374,856

G

enhancer of zeste 1 polycomb repressive complex 2 subunit

increases expression

ISO

Ellagic Acid results in increased expression of EZH1 mRNA

NCBI chr10:86,626,307...86,662,257
Ensembl chr10:86,626,308...86,652,620

G

coagulation factor XII

multiple interactions
increases activity

ISO

ALB protein promotes the reaction [Ellagic Acid results in increased activity of F12 protein]

NCBI chr17:9,212,819...9,220,664
Ensembl chr17:9,212,819...9,220,664

G

Fibroblast growth factor receptor 1

decreases expression

ISO

Ellagic Acid results in decreased expression of FGFR1 mRNA

NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855

G

filamin A

decreases expression

ISO

Ellagic Acid results in decreased expression of FLNA mRNA

NCBI chr X:157,159,051...157,185,559
Ensembl chr X:157,159,051...157,182,343

G

fibronectin 1

multiple interactions

EXP

Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein]

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

[Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of FOS mRNA]; [Ellagic Acid co-treated with Resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of FOS mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]

PMID:20103723 PMID:32971123

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

glucose-6-phosphate dehydrogenase

decreases activity

ISO

Ellagic Acid results in decreased activity of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

galanin and GMAP prepropeptide

multiple interactions

EXP

Ellagic Acid inhibits the reaction [phosalone results in increased activity of GAL protein]

NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:210,079,702...210,084,229

G

glycosylphosphatidylinositol specific phospholipase D1

decreases expression

ISO

Ellagic Acid results in decreased expression of GPLD1 mRNA

NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,512,660...40,554,975

G

glutamic--pyruvic transaminase

multiple interactions

EXP
ISO

Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein]; Ellagic Acid inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
Ellagic Acid inhibits the reaction [Diquat results in increased activity of GPT protein]

PMID:24877639 PMID:29935397 PMID:35268077

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

multiple interactions

EXP
ISO

Ellagic Acid inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]
Ellagic Acid inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]

PMID:29935397 PMID:35268077

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione-disulfide reductase

multiple interactions

EXP

Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 4

increases expression

ISO

Ellagic Acid results in increased expression of GSTA4 mRNA

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488

G

glutathione S-transferase theta 1

affects expression

EXP

Ellagic Acid affects the expression of GSTT1 protein

NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019

G

general transcription factor IIE subunit 2

increases expression

ISO

Ellagic Acid results in increased expression of GTF2E2 mRNA

NCBI chr16:65,102,386...65,152,563
Ensembl chr16:65,102,390...65,161,394

G

general transcription factor 2H subunit 4

increases expression

ISO

Ellagic Acid results in increased expression of GTF2H4 mRNA

NCBI chr20:3,076,110...3,081,805
Ensembl chr20:3,076,088...3,081,760

G

glucuronidase, beta

multiple interactions

EXP

Ellagic Acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr12:32,337,281...32,350,838
Ensembl chr12:32,334,075...32,363,024

G

hypoxia inducible factor 1 subunit alpha

decreases expression

ISO

Ellagic Acid results in decreased expression of HIF1A mRNA

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

holocarboxylase synthetase

decreases activity

ISO

Ellagic Acid results in decreased activity of HLCS protein

NCBI chr11:46,925,491...47,123,111
Ensembl chr11:46,925,491...47,105,082

G

heme oxygenase 1

increases expression
multiple interactions

ISO

Ellagic Acid results in increased expression of HMOX1 mRNA; Ellagic Acid results in increased expression of HMOX1 protein
Ellagic Acid inhibits the reaction [Diquat results in decreased expression of HMOX1 mRNA]
[Paraquat co-treated with Ellagic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Ellagic Acid] results in increased expression of HMOX1 protein

PMID:22386815 PMID:23546295 PMID:35268077

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

HRas proto-oncogene, GTPase

multiple interactions

ISO

[Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]; [Ellagic Acid co-treated with resveratrol] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased mutagenesis of HRAS gene]

NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590

G

immediate early response 2

increases expression

ISO

Ellagic Acid results in increased expression of IER2 mRNA

NCBI chr19:40,399,373...40,400,897
Ensembl chr19:40,398,160...40,402,708

G

interferon gamma

multiple interactions

EXP

Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of IFNG mRNA]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

insulin-like growth factor binding protein 2

increases expression

ISO

Ellagic Acid results in increased expression of IGFBP2 mRNA

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

insulin-like growth factor binding protein 4

decreases expression

ISO

Ellagic Acid results in decreased expression of IGFBP4 mRNA

NCBI chr10:84,491,471...84,503,487
Ensembl chr10:84,485,775...84,503,473

G

interleukin 1 beta

decreases expression
multiple interactions

ISO
EXP

Ellagic Acid results in decreased expression of IL1B mRNA
Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL1B protein]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of IL1B protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of IL1B protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of IL1B mRNA]; Ellagic Acid inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]
Ellagic Acid inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]

PMID:18377686 PMID:20816778 PMID:21762681 PMID:24877639 PMID:27965107 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 1

decreases expression

ISO

Ellagic Acid results in decreased expression of IL1R1 mRNA

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 6

multiple interactions

EXP

Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of IL6 protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of IL6 protein]

PMID:21762681 PMID:24877639 PMID:27965107

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inositol polyphosphate-5-phosphatase D

increases expression

ISO

Ellagic Acid results in increased expression of INPP5D mRNA

NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:95,735,530...95,840,589

G

IQ motif containing GTPase activating protein 2

increases expression

ISO

Ellagic Acid results in increased expression of IQGAP2 mRNA

NCBI chr 2:28,629,558...28,904,649
Ensembl chr 2:28,629,558...28,904,649

G

interferon regulatory factor 9

increases expression

ISO

Ellagic Acid results in increased expression of IRF9 mRNA

NCBI chr15:33,065,422...33,071,881
Ensembl chr15:33,065,659...33,071,879

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

ISO

Ellagic Acid results in decreased expression of JUN mRNA; Ellagic Acid results in decreased expression of JUN protein modified form

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

kallikrein 1-related peptidase C10

decreases expression

ISO

Ellagic Acid results in decreased expression of KLK3 mRNA

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586

G

lipopolysaccharide-induced TNF factor

increases expression

ISO

Ellagic Acid results in increased expression of LITAF mRNA

NCBI chr10:5,163,258...5,199,930
Ensembl chr10:5,163,242...5,199,930

G

microtubule-associated protein 1A

decreases expression

ISO

Ellagic Acid results in decreased expression of MAP1A mRNA

NCBI chr 3:128,716,907...128,736,638
Ensembl chr 3:128,716,940...128,740,159

G

mitogen-activated protein kinase kinase kinase 1

decreases expression

ISO

Ellagic Acid results in decreased expression of MAP3K1 mRNA; Ellagic Acid results in decreased expression of MAP3K1 protein

NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897

G

mitogen activated protein kinase 1

multiple interactions

ISO
EXP

Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]
Ellagic Acid inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]

PMID:32971123 PMID:38356441

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen-activated protein kinase 11

increases expression

ISO

Ellagic Acid results in increased expression of MAPK11 mRNA

NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038

G

mitogen activated protein kinase 14

multiple interactions

EXP

Ellagic Acid inhibits the reaction [phosalone results in increased expression of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions

ISO
EXP

Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]
Ellagic Acid inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]

PMID:32971123 PMID:38356441

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

ISO

[Ellagic Acid co-treated with Quercetin] results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions

ISO

[Ellagic Acid co-treated with Quercetin] results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

microsomal glutathione S-transferase 1

decreases activity

EXP

Ellagic Acid results in decreased activity of MGST1 protein

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

microRNA 140

multiple interactions

EXP

ellagic acid inhibits the reaction [hypoxia and acute myocardial infarction decreases expression of mir140 RNA in cardiac muscle cells]

RGD

NCBI chr19:52,375,293...52,375,391
Ensembl chr19:52,375,293...52,375,391

G

monocyte to macrophage differentiation-associated

increases expression

ISO

Ellagic Acid results in increased expression of MMD mRNA

NCBI chr10:75,570,366...75,598,610
Ensembl chr10:75,570,397...75,598,609

G

matrix metallopeptidase 2

multiple interactions
decreases expression
decreases activity

ISO

Ellagic Acid results in decreased activity of and results in decreased secretion of MMP2 protein; zinc chloride inhibits the reaction [Ellagic Acid results in decreased activity of and results in decreased secretion of MMP2 protein]
Ellagic Acid results in decreased expression of MMP2 mRNA
Ellagic Acid results in decreased activity of MMP2 protein

PMID:21573219 PMID:35179410

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

decreases expression
decreases activity

ISO

Ellagic Acid results in decreased expression of MMP9 mRNA
Ellagic Acid results in decreased activity of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myosin heavy chain 7

multiple interactions

EXP

Ellagic Acid inhibits the reaction [AGT protein results in increased expression of MYH7 mRNA]

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194

G

neutrophil cytosolic factor 2

multiple interactions

EXP

Ellagic Acid inhibits the reaction [AGT protein results in increased expression of NCF2 mRNA]

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149

G

nuclear factor of activated T-cells 1

multiple interactions

ISO

Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

NFE2 like bZIP transcription factor 2

affects localization
multiple interactions
increases expression
affects response to substance

ISO
EXP

Ellagic Acid affects the localization of NFE2L2 protein
Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]
Ellagic Acid results in increased expression of NFE2L2 mRNA
[Ellagic Acid co-treated with Diquat] results in increased expression of NFE2L2 mRNA; Ellagic Acid inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]; Ellagic Acid inhibits the reaction [sodium arsenate results in decreased expression of NFE2L2 mRNA]
[Paraquat co-treated with Ellagic Acid] results in increased expression of and affects the localization of NFE2L2 protein; [Paraquat co-treated with Ellagic Acid] results in increased expression of NFE2L2 mRNA; Ellagic Acid results in increased expression of and affects the localization of NFE2L2 protein
Ellagic Acid results in increased expression of NFE2L2 mRNA; Ellagic Acid results in increased expression of NFE2L2 protein
NFE2L2 protein affects the susceptibility to Ellagic Acid

PMID:22386815 PMID:23546295 PMID:30503583 PMID:35236242 PMID:35268077

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 2

decreases expression

ISO

Ellagic Acid results in decreased expression of NFKB2 mRNA

PMID:12002526 PMID:35179410

NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637

G

neuronatin

increases expression

ISO

Ellagic Acid results in increased expression of NNAT mRNA

NCBI chr 3:166,646,373...166,648,845
Ensembl chr 3:166,646,384...166,649,086

G

NOP56 ribonucleoprotein

decreases expression

ISO

Ellagic Acid results in decreased expression of NOP56 mRNA

NCBI chr 3:137,926,187...137,934,971
Ensembl chr 3:137,929,646...137,934,959

G

nitric oxide synthase 2

multiple interactions
decreases expression

EXP
ISO

Ellagic Acid inhibits the reaction [AGT protein results in increased expression of NOS2 mRNA]; Ellagic Acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]
Ellagic Acid results in decreased expression of NOS2 mRNA

PMID:28815802 PMID:35179410 PMID:38356441

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

neuronal PAS domain protein 2

increases expression

ISO

Ellagic Acid results in increased expression of NPAS2 mRNA

NCBI chr 9:48,959,225...49,138,036
Ensembl chr 9:48,959,148...49,138,037

G

natriuretic peptide A

multiple interactions

EXP

Ellagic Acid inhibits the reaction [AGT protein results in increased expression of NPPA mRNA]

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide B

multiple interactions

EXP

Ellagic Acid inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

ISO

Ellagic Acid results in increased expression of NQO1 mRNA; Ellagic Acid results in increased expression of NQO1 protein
Ellagic Acid inhibits the reaction [Diquat results in decreased expression of NQO1 mRNA]
[Paraquat co-treated with Ellagic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Ellagic Acid] results in increased expression of NQO1 protein

PMID:23546295 PMID:35268077

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 3

increases activity

ISO

Ellagic Acid results in increased activity of NR1I3 protein

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

poly (ADP-ribose) glycohydrolase

decreases activity

ISO

Ellagic Acid results in decreased activity of PARG protein

NCBI chr16:7,442,696...7,550,585
Ensembl chr16:7,442,726...7,550,584

G

poly (ADP-ribose) polymerase 1

multiple interactions

EXP

Ellagic Acid inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

proliferating cell nuclear antigen

multiple interactions

ISO

[resveratrol co-treated with Ellagic Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCNA mRNA]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

protein disulfide isomerase family A, member 2

multiple interactions

EXP

Ellagic Acid inhibits the reaction [Rotenone results in increased nitrosation of and results in decreased activity of PDIA2 protein]

NCBI chr10:15,720,301...15,723,386
Ensembl chr10:15,720,301...15,723,396

G

phosphogluconate dehydrogenase

decreases activity

ISO

Ellagic Acid results in decreased activity of PGD protein

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

phospholipase A2 group IIA

decreases expression

ISO

Ellagic Acid results in decreased expression of PLA2G2A mRNA

NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297

G

proteolipid protein 2

increases expression

ISO

Ellagic Acid results in increased expression of PLP2 mRNA

NCBI chr X:17,506,153...17,509,552
Ensembl chr X:17,506,059...17,509,550

G

PML nuclear body scaffold

decreases expression

ISO

Ellagic Acid results in decreased expression of PML mRNA

NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:67,523,164...67,576,083

G

peroxisome proliferator-activated receptor delta

decreases expression

ISO

Ellagic Acid results in decreased expression of PPARD mRNA

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

peroxisome proliferator-activated receptor gamma

increases expression

ISO

Ellagic Acid results in increased expression of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

multiple interactions
decreases expression

ISO

Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of PPARGC1A mRNA]
Ellagic Acid results in decreased expression of PPARGC1A mRNA

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

protein kinase cGMP-dependent 1

decreases expression

ISO

Ellagic Acid results in decreased expression of PRKG1 mRNA

NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005

G

pleiotrophin

decreases expression
increases expression

ISO

Ellagic Acid results in decreased expression of PTN mRNA
Ellagic Acid results in increased expression of PTN mRNA

NCBI chr 4:66,260,764...66,342,614
Ensembl chr 4:66,260,764...66,342,482

G

protein tyrosine phosphatase, receptor type N2

increases expression

ISO

Ellagic Acid results in increased expression of PTPRN2 mRNA

NCBI chr 6:143,582,568...144,334,573
Ensembl chr 6:143,582,547...144,336,744

G

RAN, member RAS oncogene family

decreases expression

ISO

Ellagic Acid results in decreased expression of RAN mRNA

NCBI chr12:33,311,155...33,314,339
Ensembl chr12:33,311,158...33,314,317

G

RB transcriptional corepressor 1

multiple interactions

EXP

Ellagic Acid inhibits the reaction [phosalone results in increased expression of RB1 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of RB1 protein]

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

reversion-inducing-cysteine-rich protein with kazal motifs

increases expression
multiple interactions

ISO

Ellagic Acid results in increased expression of RECK mRNA; Ellagic Acid results in increased expression of RECK protein
zinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK mRNA]; zinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK protein]

NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:62,898,668...62,965,270

G

RELA proto-oncogene, NF-kB subunit

decreases expression
multiple interactions

ISO
EXP

Ellagic Acid results in decreased expression of RELA mRNA
Ellagic Acid inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein]
Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RELA protein]
Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of RELA protein]; Ellagic Acid inhibits the reaction [AGT protein results in increased activity of RELA protein]; Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of RELA protein]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of RELA protein]

PMID:12002526 PMID:24877639 PMID:27473819 PMID:27965107 PMID:32971123 More...

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

regulator of G-protein signaling 5

decreases expression

ISO

Ellagic Acid results in decreased expression of RGS5 mRNA

NCBI chr13:84,381,077...84,417,875
Ensembl chr13:84,380,910...84,421,352

G

RUNX family transcription factor 2

increases expression

ISO

Ellagic Acid results in increased expression of RUNX2 mRNA; Ellagic Acid results in increased expression of RUNX2 protein

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

stearoyl-CoA desaturase

decreases expression

ISO

Ellagic Acid results in decreased expression of SCD mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

septin 2

increases expression

ISO

Ellagic Acid results in increased expression of SEPTIN2 mRNA

NCBI chr 9:101,465,535...101,498,766
Ensembl chr 9:101,465,650...101,498,759

G

superoxide dismutase 1

multiple interactions

EXP

Ellagic Acid inhibits the reaction [Aluminum Chloride results in decreased expression of SOD1 mRNA]; Ellagic Acid inhibits the reaction [Aluminum Chloride results in decreased expression of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions

EXP

Ellagic Acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

superoxide dismutase 3

decreases expression

ISO

Ellagic Acid results in decreased expression of SOD3 mRNA

NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125

G

Sp7 transcription factor

increases expression

ISO

Ellagic Acid results in increased expression of SP7 mRNA; Ellagic Acid results in increased expression of SP7 protein

NCBI chr 7:135,363,193...135,373,376
Ensembl chr 7:135,363,199...135,373,559

G

secreted phosphoprotein 1

increases expression

ISO

Ellagic Acid results in increased expression of SPP1 mRNA; Ellagic Acid results in increased expression of SPP1 protein

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

ISO

Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC protein]

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

steroidogenic acute regulatory protein

increases expression
multiple interactions

ISO

Ellagic Acid results in increased expression of STAR mRNA
Ellagic Acid inhibits the reaction [sodium arsenate results in decreased expression of STAR mRNA]

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

signal transducer and activator of transcription 3

increases expression
decreases expression

ISO

Ellagic Acid results in increased expression of STAT3 mRNA
Ellagic Acid results in decreased expression of STAT3 mRNA

PMID:12002526 PMID:20816778

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

TATA-box binding protein associated factor, RNA polymerase 1 subunit C

decreases expression

ISO

Ellagic Acid results in decreased expression of TAF1C mRNA

NCBI chr19:64,561,079...64,567,599
Ensembl chr19:64,560,562...64,567,599

G

transcription factor 12

increases expression

ISO

Ellagic Acid results in increased expression of TCF12 mRNA

NCBI chr 8:81,371,201...81,682,337
Ensembl chr 8:81,373,321...81,679,922

G

telomerase reverse transcriptase

multiple interactions
increases expression

ISO
EXP

Ellagic Acid inhibits the reaction [Estradiol results in increased expression of TERT mRNA alternative form]
Ellagic Acid inhibits the reaction [phosalone results in decreased activity of TERT protein]
Ellagic Acid results in increased expression of TERT mRNA alternative form

PMID:19501078 PMID:27965107

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111

G

transcription factor A, mitochondrial

decreases expression

ISO

Ellagic Acid results in decreased expression of TFAM mRNA

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

transforming growth factor, beta 1

increases expression
multiple interactions

ISO
EXP

Ellagic Acid results in increased expression of TGFB1 mRNA
Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]

PMID:12002526 PMID:24877639

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions
decreases expression

EXP
ISO

Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [chromium hexavalent ion results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [Glucose results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of TNF mRNA]; Ellagic Acid inhibits the reaction [sodium arsenate results in increased expression of TNF protein]; Ellagic Acid inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
Ellagic Acid inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein]; Ellagic Acid inhibits the reaction [TNF protein results in increased activity of and affects the secretion of CXCL8 protein]
Ellagic Acid results in decreased expression of TNF mRNA

PMID:21762681 PMID:24877639 PMID:27473819 PMID:27965107 PMID:28815802 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 11A

multiple interactions
affects binding

ISO

Ellagic Acid inhibits the reaction [TNFSF11 protein binds to TNFRSF11A protein]
Ellagic Acid binds to TNFRSF11A protein

NCBI chr13:22,442,930...22,501,257
Ensembl chr13:22,442,665...22,501,257

G

TNF superfamily member 11

multiple interactions
affects binding

ISO

Ellagic Acid inhibits the reaction [TNFSF11 protein binds to TNFRSF11A protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of CTSK protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]; Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RELA protein]
Ellagic Acid binds to TNFSF11 protein

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

troponin T2, cardiac type

multiple interactions

EXP

Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]

NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125

G

tumor protein p53

increases expression
multiple interactions

ISO
EXP

Ellagic Acid results in increased expression of TP53 mRNA; Ellagic Acid results in increased expression of TP53 protein
Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]]
Ellagic Acid inhibits the reaction [phosalone results in increased expression of TP53 mRNA]; Ellagic Acid inhibits the reaction [phosalone results in increased expression of TP53 protein]

PMID:15735102 PMID:23554011 PMID:27965107 PMID:35179410

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

UDP-glucose pyrophosphorylase 2

decreases expression

ISO

Ellagic Acid results in decreased expression of UGP2 mRNA

NCBI chr14:99,657,637...99,698,573
Ensembl chr14:99,657,639...99,698,002

G

ubiquitin specific peptidase 4

decreases expression

ISO

Ellagic Acid results in decreased expression of USP4 mRNA

NCBI chr 8:117,912,576...117,957,934
Ensembl chr 8:117,914,614...117,957,949

G

vascular endothelial growth factor A

multiple interactions

EXP

Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

tryptophanyl-tRNA synthetase 1

increases expression

ISO

Ellagic Acid results in increased expression of WARS1 mRNA

NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645

G

WEE1 G2 checkpoint kinase

decreases expression

ISO

Ellagic Acid results in decreased expression of WEE1 protein

NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449

G

zinc finger and BTB domain containing 16

decreases expression

ISO

Ellagic Acid results in decreased expression of ZBTB16 mRNA

NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:57,891,081...58,073,507

G

zinc finger MYM-type containing 2

increases expression

ISO

Ellagic Acid results in increased expression of ZMYM2 mRNA

NCBI chr15:35,151,356...35,224,528
Ensembl chr15:35,127,994...35,224,941

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tyrosinase

decreases expression

ISO

decaprenoic acid results in decreased expression of TYR protein

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

isoliquiritigenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-fetoprotein

affects binding

EXP

isoliquiritigenin binds to AFP protein

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

aryl hydrocarbon receptor

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene affects the localization of AHR protein]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

AKT serine/threonine kinase 1

decreases response to substance
multiple interactions
decreases phosphorylation

ISO

AKT1 protein modified form results in decreased susceptibility to isoliquiritigenin
isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Leukotriene B4 inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]
isoliquiritigenin results in decreased phosphorylation of AKT1 protein

PMID:23747687 PMID:25094029 PMID:27117918

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

arginase 1

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 protein]

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

isoliquiritigenin results in increased expression of BAX mRNA; isoliquiritigenin results in increased expression of BAX protein

PMID:11055382 PMID:27702603 PMID:38311047

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases phosphorylation

ISO

isoliquiritigenin results in decreased phosphorylation of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression
decreases phosphorylation

ISO

isoliquiritigenin results in decreased expression of BCL2L1 protein
isoliquiritigenin results in decreased phosphorylation of BCL2L1 protein

PMID:11055382 PMID:15729620 PMID:23747687

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

baculoviral IAP repeat-containing 2

decreases expression

ISO

isoliquiritigenin results in decreased expression of BIRC2 protein

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

baculoviral IAP repeat-containing 3

decreases expression

ISO

isoliquiritigenin results in decreased expression of BIRC3 protein

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

caspase 3

multiple interactions
increases expression
increases activity
increases cleavage

ISO

20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP3 protein
isoliquiritigenin results in increased expression of CASP3 mRNA
isoliquiritigenin results in increased activity of CASP3 protein

PMID:15729620 PMID:16158945 PMID:23747687 PMID:25094029 PMID:38311047

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases activity

ISO

isoliquiritigenin results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions
increases expression
increases activity
increases cleavage

ISO

20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP9 protein
isoliquiritigenin results in increased expression of CASP9 mRNA
isoliquiritigenin results in increased activity of CASP9 protein

PMID:16158945 PMID:23747687 PMID:25094029 PMID:38311047

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
increases expression

EXP
ISO

isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
isoliquiritigenin results in increased expression of CAT mRNA
isoliquiritigenin inhibits the reaction [Paroxetine results in decreased activity of CAT protein]

PMID:25450236 PMID:36740106 PMID:38311047

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cholecystokinin A receptor

multiple interactions
increases expression

ISO

fulvestrant inhibits the reaction [isoliquiritigenin results in increased expression of CCKAR mRNA]

NCBI chr14:61,505,270...61,513,618
Ensembl chr14:61,505,270...61,513,618

G

cyclin D2

decreases expression

ISO

isoliquiritigenin results in decreased expression of CCND2 mRNA

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

cyclin E2

decreases expression

ISO

isoliquiritigenin results in decreased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

isoliquiritigenin results in increased expression of CDKN1A mRNA; isoliquiritigenin results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

decreases expression

ISO

isoliquiritigenin results in decreased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cyclin-dependent kinase inhibitor 1C

decreases expression

ISO

isoliquiritigenin results in decreased expression of CDKN1C mRNA

NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:208,084,787...208,087,498

G

CCAAT/enhancer binding protein alpha

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of CEBPA protein]

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of CHUK protein]

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

cathepsin B

decreases expression

ISO

isoliquiritigenin results in decreased expression of CTSB protein

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

C-X-C motif chemokine ligand 10

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CXCL10 mRNA]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

ISO

isoliquiritigenin results in decreased expression of CYP17A1 mRNA

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases expression

ISO

isoliquiritigenin results in decreased expression of CYP19A1 mRNA

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity

ISO

isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A2 mRNA]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
isoliquiritigenin results in decreased activity of CYP1A2 protein

PMID:25110319 PMID:29753067

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases expression

ISO

isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]
isoliquiritigenin results in increased expression of CYP1B1 mRNA

PMID:25110319 PMID:26134484

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

ISO

isoliquiritigenin results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP

isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

isoliquiritigenin results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DNA-damage inducible transcript 3

multiple interactions

EXP

isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

EXP

isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of ERN1 mRNA]

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

fatty acid binding protein 4

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of FABP4 protein]

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

forkhead box O3

decreases expression

ISO

isoliquiritigenin results in decreased expression of FOXO3 mRNA

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

GADD45G interacting protein 1

increases expression

ISO

isoliquiritigenin results in increased expression of GADD45GIP1 mRNA

NCBI chr19:40,225,503...40,228,052
Ensembl chr19:40,225,984...40,228,055

G

glial fibrillary acidic protein

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of GFAP protein]

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

glutamic--pyruvic transaminase

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [Paroxetine results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

decreases expression

ISO

isoliquiritigenin results in decreased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione-disulfide reductase

multiple interactions

EXP

isoliquiritigenin inhibits the reaction [Cisplatin results in decreased activity of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

hepatitis A virus cellular receptor 1

multiple interactions

EXP

isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 protein]

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

heme oxygenase 1

increases expression

ISO

isoliquiritigenin results in increased expression of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hydroxysteroid (17-beta) dehydrogenase 1

decreases expression

ISO

isoliquiritigenin results in decreased expression of HSD17B1 mRNA

NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210

G

heat shock protein 90 beta family member 1

multiple interactions

EXP

[isoliquiritigenin co-treated with Cisplatin] results in increased expression of HSP90B1 protein

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

EXP

[Cisplatin co-treated with isoliquiritigenin] results in increased expression of HSPA5 mRNA
isoliquiritigenin results in increased expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

interferon gamma

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IFNG protein]; isoliquiritigenin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]
isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]

PMID:23942037 PMID:25026504 PMID:26134484

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 10

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 receptor antagonist

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN protein]

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732

G

interleukin 6

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]

PMID:18295200 PMID:25026504

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 1

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [INS1 protein results in decreased activity of and results in increased oxidation of PTPN1 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of CEBPA protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of FABP4 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of PPARG protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin receptor

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein]

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803

G

integrin subunit alpha M

multiple interactions
increases expression

ISO

TEMPOL-H inhibits the reaction [isoliquiritigenin results in increased expression of ITGAM protein]

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

microtubule-associated protein 1 light chain 3 beta

decreases expression

ISO

isoliquiritigenin results in decreased expression of MAP1LC3B protein

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

mitogen activated protein kinase 1

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

maternal embryonic leucine zipper kinase

decreases expression

ISO

isoliquiritigenin results in decreased expression of MELK mRNA; isoliquiritigenin results in decreased expression of MELK protein

NCBI chr 5:63,336,151...63,396,254
Ensembl chr 5:63,336,106...63,396,247

G

mitofusin 2

increases expression

EXP

isoliquiritigenin results in increased expression of MFN2 protein

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

marker of proliferation Ki-67

decreases expression

ISO

isoliquiritigenin results in decreased expression of MKI67 mRNA; isoliquiritigenin results in decreased expression of MKI67 protein

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

matrix metallopeptidase 2

multiple interactions
decreases expression

ISO

20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]
isoliquiritigenin results in decreased expression of MMP2 mRNA; isoliquiritigenin results in decreased expression of MMP2 protein

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

multiple interactions
decreases expression

ISO

20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]
isoliquiritigenin results in decreased expression of MMP9 mRNA; isoliquiritigenin results in decreased expression of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

mannose receptor, C type 1

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 protein]

NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410

G

NFE2 like bZIP transcription factor 2

decreases expression

ISO

isoliquiritigenin results in decreased expression of NFE2L2 mRNA

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of NFKB1 protein]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

increases expression
multiple interactions
decreases phosphorylation

ISO

isoliquiritigenin results in increased expression of NFKBIA protein
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of and results in increased phosphorylation of NFKBIA protein]
isoliquiritigenin results in decreased phosphorylation of NFKBIA protein

PMID:15729620 PMID:18295200

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of NOS2 protein]

PMID:18295200 PMID:19834288 PMID:25026504 PMID:26134484

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

increases expression

ISO

isoliquiritigenin results in increased expression of NQO1 protein

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 2

increases activity
increases expression

ISO

isoliquiritigenin results in increased activity of NR1I2 protein
isoliquiritigenin results in increased expression of NR1I2 mRNA

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ISO

isoliquiritigenin results in increased cleavage of PARP1 protein
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

pyruvate dehydrogenase kinase 1

decreases phosphorylation

ISO

isoliquiritigenin results in decreased phosphorylation of PDK1 protein

NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145

G

phospholipase A2, group V

decreases expression

ISO

isoliquiritigenin results in decreased expression of PLA2G5 mRNA

NCBI chr 5:156,324,628...156,393,065
Ensembl chr 5:156,324,629...156,381,926

G

POU class 5 homeobox 1

increases expression

ISO

isoliquiritigenin results in increased expression of POU5F1 mRNA

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598

G

peroxisome proliferator-activated receptor gamma

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of PPARG protein]

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

prostaglandin E receptor 4

decreases expression

ISO

isoliquiritigenin results in decreased expression of PTGER4 mRNA; isoliquiritigenin results in decreased expression of PTGER4 protein

NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:56,062,890...56,074,135

G

prostaglandin-endoperoxide synthase 1

decreases expression

ISO

isoliquiritigenin results in decreased expression of PTGS1 mRNA

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

ISO
EXP

isoliquiritigenin results in decreased expression of PTGS2 mRNA
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]

PMID:18295200 PMID:23747687 PMID:25026504 PMID:25450236

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine phosphatase, non-receptor type 1

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [INS1 protein results in decreased activity of and results in increased oxidation of PTPN1 protein]

NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416

G

RELA proto-oncogene, NF-kB subunit

affects localization
multiple interactions
decreases activity

ISO

isoliquiritigenin affects the localization of RELA protein
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]
isoliquiritigenin results in decreased activity of RELA protein

PMID:15729620 PMID:18295200

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

sirtuin 1

increases expression

ISO

isoliquiritigenin results in increased expression of SIRT1 mRNA

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 2 member 1

multiple interactions
decreases activity

ISO

isoliquiritigenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
isoliquiritigenin results in decreased activity of SLC2A1 protein

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 2 member 4

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 6 member 3

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

solute carrier organic anion transporter family, member 1c1

multiple interactions
decreases activity

EXP

[isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate

NCBI chr 4:176,197,736...176,244,401
Ensembl chr 4:176,197,741...176,244,395

G

superoxide dismutase 2

affects response to substance
increases expression

ISO

SOD2 protein affects the susceptibility to isoliquiritigenin
isoliquiritigenin results in increased expression of SOD2 mRNA

PMID:23526725 PMID:38311047

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

steroidogenic acute regulatory protein

increases expression

ISO

isoliquiritigenin results in increased expression of STAR mRNA

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

signal transducer and activator of transcription 3

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

transforming growth factor, beta 1

multiple interactions

ISO

isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TGFB1 protein]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions

ISO
EXP

isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TNF protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]

PMID:18295200 PMID:25026504 PMID:25450236 PMID:26134484

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

increases expression

ISO

isoliquiritigenin results in increased expression of TRP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

ISO

UGT1A1 protein results in increased glucuronidation of isoliquiritigenin

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of isoliquiritigenin

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

X-box binding protein 1

multiple interactions

EXP

isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of XBP1 mRNA]

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases transport
increases activity
multiple interactions
decreases expression
increases expression

ISO

ABCB1 protein results in increased transport of 3-methylquercetin
3-methylquercetin results in increased activity of ABCB1 protein
3-methylquercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 3-methylquercetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; 3-methylquercetin promotes the reaction [Quercetin results in increased activity of ABCB1 protein]
3-methylquercetin results in decreased expression of ABCB1 protein
3-methylquercetin results in increased expression of ABCB1 mRNA

PMID:15969930 PMID:26238175 PMID:34217736

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 1

decreases activity

ISO

3-methylquercetin results in decreased activity of ABCC1 protein

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

actin alpha 2, smooth muscle

multiple interactions

ISO

3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

angiotensinogen

multiple interactions

EXP

3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

aryl hydrocarbon receptor

multiple interactions

ISO

3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

ISO
EXP

3-methylquercetin results in decreased phosphorylation of AKT1 protein
3-methylquercetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]

PMID:12826665 PMID:19222219

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2, apoptosis regulator

decreases expression

ISO

3-methylquercetin results in decreased expression of BCL2 mRNA; 3-methylquercetin results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression

ISO

3-methylquercetin results in decreased expression of BCL2L1 mRNA; 3-methylquercetin results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

decreases expression
multiple interactions
increases activity

ISO
EXP

3-methylquercetin results in decreased expression of CASP3 protein
3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
3-methylquercetin results in increased activity of CASP3 protein

PMID:12826665 PMID:19222219 PMID:22992727

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

decreases expression

ISO

3-methylquercetin results in decreased expression of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

EXP

3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT protein

PMID:19222219 PMID:25716194

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 3

multiple interactions

ISO

[3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

cyclin D1

decreases expression

ISO

3-methylquercetin results in decreased expression of CCND1 mRNA; 3-methylquercetin results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cadherin 1

increases expression

ISO

3-methylquercetin results in increased expression of CDH1 mRNA; 3-methylquercetin results in increased expression of CDH1 protein

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

collagen type I alpha 1 chain

multiple interactions

ISO

3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

ISO

3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases expression

ISO

3-methylquercetin results in decreased expression of CYP1B1 mRNA

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

ISO

3-methylquercetin results in increased expression of CYP3A4 mRNA

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

endothelin 1

multiple interactions

EXP

3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

estrogen receptor 1

affects binding

ISO

3-methylquercetin binds to ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

affects binding

ISO

3-methylquercetin binds to ESR2 protein

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein
3-methylquercetin results in increased expression of GCLC mRNA; 3-methylquercetin results in increased expression of GCLC protein

PMID:24211276 PMID:25716194

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamic--pyruvic transaminase

multiple interactions

ISO

3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

heme oxygenase 1

multiple interactions
increases expression

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein
3-methylquercetin results in increased expression of HMOX1 mRNA; 3-methylquercetin results in increased expression of HMOX1 protein
3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of HMOX1 mRNA]; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein

PMID:24211276 PMID:24337631 PMID:25716194 PMID:27151496

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

interleukin 1 beta

multiple interactions

EXP
ISO

3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL1B protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL1B mRNA

PMID:20579867 PMID:23774260

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

EXP
ISO

3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL6 protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL6 mRNA

PMID:20579867 PMID:23774260

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

mitogen activated protein kinase 14

decreases expression

ISO

3-methylquercetin results in decreased expression of MAPK14 mRNA; 3-methylquercetin results in decreased expression of MAPK14 protein

PMID:36819991 PMID:37537191

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen-activated protein kinase 8

multiple interactions

EXP

3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

microRNA 155

multiple interactions

ISO

3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of MIR155 mRNA]

NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178

G

mechanistic target of rapamycin kinase

decreases phosphorylation

ISO

3-methylquercetin results in decreased phosphorylation of MTOR protein

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

neutrophil cytosolic factor 1

multiple interactions

EXP

3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein]

PMID:17374653 PMID:18436224

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079

G

NFE2 like bZIP transcription factor 2

affects response to substance
multiple interactions
affects localization
increases activity

ISO

NFE2L2 protein affects the susceptibility to 3-methylquercetin
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; 3-methylquercetin affects the localization of and results in increased phosphorylation of and results in increased activity of NFE2L2 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased abundance of Glutathione; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
3-methylquercetin affects the localization of NFE2L2 protein
[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; NFE2L2 protein affects the reaction [3-methylquercetin results in decreased susceptibility to tert-Butylhydroperoxide]

PMID:24211276 PMID:27151496

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions

ISO

3-methylquercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of NOS2 mRNA

PMID:16213685 PMID:18178435 PMID:18274639 PMID:20579867 PMID:23774260

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

multiple interactions

ISO

3-methylquercetin inhibits the reaction [Lipids results in decreased expression of NOS3]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

[3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

ISO

3-methylquercetin binds to and results in increased activity of NR1I2 protein
3-methylquercetin results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

oxidized low density lipoprotein receptor 1

multiple interactions

ISO

3-methylquercetin inhibits the reaction [Lipids results in increased expression of OLR1]

NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:164,612,463...164,634,598

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

3-methylquercetin results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

platelet and endothelial cell adhesion molecule 1

decreases expression

ISO

3-methylquercetin results in decreased expression of PECAM1 protein

NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839

G

paraoxonase 1

increases expression

ISO

3-methylquercetin results in increased expression of PON1 mRNA

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924

G

paraoxonase 2

increases expression

ISO

3-methylquercetin results in increased expression of PON2 mRNA

NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:34,356,274...34,391,996

G

peroxisome proliferator-activated receptor delta

increases activity

ISO

3-methylquercetin results in increased activity of PPARD protein

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

ISO

2-chloro-5-nitrobenzanilide inhibits the reaction [3-methylquercetin results in increased activity of PPARG protein]; 3-methylquercetin binds to and results in increased activity of PPARG protein
3-methylquercetin results in increased expression of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein kinase C, delta

increases phosphorylation

ISO

3-methylquercetin results in increased phosphorylation of PRKCD protein

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

prostaglandin E synthase

multiple interactions

ISO

3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA]

NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases activity

ISO
EXP

3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Acetylcysteine promotes the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]; tin protoporphyrin IX inhibits the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]
3-methylquercetin results in decreased activity of PTGS2 protein
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein]

PMID:15292928 PMID:21341175 PMID:24337631

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]

PMID:18274639 PMID:20579867 PMID:23774260

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

serpin family E member 1

multiple interactions

ISO

3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]
3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

sestrin 2

multiple interactions

ISO

[3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

SMAD family member 2

multiple interactions

ISO

3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388

G

SMAD family member 3

multiple interactions

ISO

3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

trefoil factor 1

increases expression

ISO

3-methylquercetin results in increased expression of TFF1 mRNA

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

transforming growth factor, beta 1

multiple interactions

ISO

3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions

EXP
ISO

3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of TNF protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

PMID:20579867 PMID:23774260

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tyrosinase

increases expression

ISO

3-methylquercetin results in increased expression of TYR protein

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

tyrosinase-related protein 1

increases expression

ISO

3-methylquercetin results in increased expression of TYRP1 protein

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:100,327,125...100,345,657

G

vimentin

decreases expression

ISO

3-methylquercetin results in decreased expression of VIM mRNA; 3-methylquercetin results in decreased expression of VIM protein

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 13

decreases expression

ISO

kojic acid results in decreased expression of ABCA13 mRNA

NCBI chr14:88,087,146...88,589,868
Ensembl chr14:88,087,801...88,589,392

G

ATP binding cassette subfamily C member 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in increased expression of ABCC2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of ABCC2 mRNA

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 6

multiple interactions

ISO
EXP

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCC6 mRNA
[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of ABCC6 mRNA

PMID:17917374 PMID:18544905

NCBI chr 1:105,583,681...105,637,895
Ensembl chr 1:105,583,682...105,637,895

G

ATP binding cassette subfamily C member 9

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCC9 mRNA

NCBI chr 4:177,262,848...177,386,837
Ensembl chr 4:177,262,848...177,386,348

G

ATP binding cassette subfamily D member 1

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCD1 mRNA

NCBI chr X:156,579,669...156,601,448
Ensembl chr X:156,579,785...156,601,446

G

ATP binding cassette subfamily F member 2

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of ABCF2 mRNA

NCBI chr 4:11,485,865...11,500,067
Ensembl chr 4:11,487,395...11,500,053

G

abhydrolase domain containing 1

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of ABHD1 mRNA

NCBI chr 6:31,142,476...31,147,464
Ensembl chr 6:31,142,476...31,147,464

G

alkaline ceramidase 3

increases expression

ISO

kojic acid results in increased expression of ACER3 mRNA

NCBI chr 1:161,915,397...162,017,802
Ensembl chr 1:161,915,397...162,017,912

G

aminocarboxymuconate semialdehyde decarboxylase

decreases expression

ISO

kojic acid results in decreased expression of ACMSD mRNA

NCBI chr13:41,752,894...41,798,427
Ensembl chr13:41,752,875...41,798,427

G

activin A receptor like type 1

decreases expression

ISO

kojic acid results in decreased expression of ACVRL1 mRNA

NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:134,118,024...134,135,305

G

adrenoceptor beta 3

decreases expression

ISO

kojic acid results in decreased expression of ADRB3 mRNA

NCBI chr16:71,544,603...71,547,410
Ensembl chr16:71,542,567...71,547,420

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

increases expression

ISO

kojic acid results in increased expression of AGAP3 mRNA

NCBI chr 4:11,567,191...11,617,610
Ensembl chr 4:11,567,191...11,617,285

G

AGBL carboxypeptidase 4

decreases expression

ISO

kojic acid results in decreased expression of AGBL4 mRNA

NCBI chr 5:130,483,551...131,762,906

G

AHNAK nucleoprotein

decreases expression

ISO

kojic acid results in decreased expression of AHNAK mRNA

NCBI chr 1:215,311,289...215,400,010
Ensembl chr 1:215,321,931...215,400,675

G

AKT serine/threonine kinase 1

decreases expression

ISO

kojic acid results in decreased expression of AKT1 mRNA

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

alkaline phosphatase, intestinal

decreases expression

ISO

kojic acid results in decreased expression of ALPI mRNA

NCBI chr 9:95,221,314...95,224,780
Ensembl chr 9:95,221,314...95,224,780

G

amelotin

decreases expression

ISO

kojic acid results in decreased expression of AMTN mRNA

NCBI chr14:19,932,664...19,945,223
Ensembl chr14:19,932,665...19,945,223

G

annexin A1

decreases expression

ISO

kojic acid results in decreased expression of ANXA1 mRNA

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831

G

annexin A5

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ANXA5 mRNA

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

ISO

kojic acid results in decreased expression of AP1S1 mRNA

NCBI chr12:25,261,958...25,272,483
Ensembl chr12:25,262,036...25,272,483

G

apolipoprotein B mRNA editing enzyme catalytic subunit 1

decreases expression

ISO

kojic acid results in decreased expression of APOBEC1 mRNA

NCBI chr 4:157,472,879...157,500,496
Ensembl chr 4:157,472,868...157,498,909

G

amyloid beta precursor protein

increases expression

ISO

kojic acid results in increased expression of APP mRNA

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

aprataxin

decreases expression

ISO

kojic acid results in decreased expression of APTX mRNA

NCBI chr 5:60,593,338...60,618,946
Ensembl chr 5:60,597,648...60,618,790

G

aquaporin 1

increases expression

ISO

kojic acid results in increased expression of AQP1 mRNA

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504

G

ARF interacting protein 2

decreases expression

ISO

kojic acid results in decreased expression of ARFIP2 mRNA

NCBI chr 1:169,387,484...169,392,290
Ensembl chr 1:169,387,485...169,392,166

G

Rho guanine nucleotide exchange factor 16

decreases expression

ISO

kojic acid results in decreased expression of ARHGEF16 mRNA

NCBI chr 5:170,126,573...170,148,624
Ensembl chr 5:170,126,575...170,148,624

G

ARF like GTPase 6 interacting protein 5

increases expression

ISO

kojic acid results in increased expression of ARL6IP5 mRNA

NCBI chr 4:131,365,320...131,395,311
Ensembl chr 4:131,367,289...131,400,130

G

asparagine synthetase domain containing 1

decreases expression

ISO

kojic acid results in decreased expression of ASNSD1 mRNA

NCBI chr 9:55,618,799...55,631,064
Ensembl chr 9:55,618,799...55,631,064

G

activating transcription factor 6 beta

decreases expression

ISO

kojic acid results in decreased expression of ATF6B mRNA

NCBI chr20:4,095,534...4,103,534
Ensembl chr20:4,095,534...4,106,032

G

ATM serine/threonine kinase

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

beta-1,4-N-acetyl-galactosaminyl transferase 4

decreases expression

ISO

kojic acid results in decreased expression of B4GALNT4 mRNA

NCBI chr 1:205,600,989...205,611,889
Ensembl chr 1:205,600,989...205,611,889

G

BAG cochaperone 5

decreases expression

ISO

kojic acid results in decreased expression of BAG5 mRNA

NCBI chr 6:136,589,623...136,593,278
Ensembl chr 6:136,584,741...136,598,492

G

BCL2-related protein A1

increases expression

ISO

kojic acid results in increased expression of BCL2A1 mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

Bcl2-like 2

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of BCL2L2 mRNA

NCBI chr15:32,326,686...32,337,834
Ensembl chr15:32,326,020...32,335,379

G

baculoviral IAP repeat-containing 2

decreases expression

ISO

kojic acid results in decreased expression of BIRC2 mRNA

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

bone morphogenetic protein 5

decreases expression

ISO

kojic acid results in decreased expression of BMP5 mRNA

NCBI chr 8:85,397,629...85,520,374
Ensembl chr 8:85,396,925...85,520,189

G

BR serine/threonine kinase 1

decreases expression

ISO

kojic acid results in decreased expression of BRSK1 mRNA

NCBI chr 1:78,162,944...78,193,598
Ensembl chr 1:78,163,341...78,188,922

G

bone marrow stromal cell antigen 2

decreases expression

ISO

kojic acid results in decreased expression of BST2 mRNA

NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967

G

similar to human chromosome 1 open reading frame 54

increases expression

ISO

kojic acid results in increased expression of C1ORF54 mRNA

NCBI chr 2:186,113,922...186,124,637
Ensembl chr 2:186,113,922...186,124,335

G

similar to human chromosome 1 open reading frame 87

decreases expression

ISO

kojic acid results in decreased expression of C1ORF87 mRNA

NCBI chr 5:116,458,224...116,527,281
Ensembl chr 5:116,458,270...116,527,231

G

carbonic anhydrase 13

increases expression

ISO

kojic acid results in increased expression of CAR13 mRNA

NCBI chr 2:88,649,643...88,680,763
Ensembl chr 2:88,649,625...88,680,763

G

carbonic anhydrase 14

increases expression

ISO

kojic acid results in increased expression of CA14 mRNA

NCBI chr 2:186,131,196...186,138,164
Ensembl chr 2:186,129,341...186,138,863

G

calcium binding protein 39-like

increases expression

ISO

kojic acid results in increased expression of CAB39L mRNA

NCBI chr15:37,782,778...37,885,191
Ensembl chr15:37,782,870...37,919,742

G

calreticulin

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CALR mRNA

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236

G

caspase 4

multiple interactions

EXP

[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CASP4 mRNA; Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CASP4 mRNA]

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727

G

caspase 8

multiple interactions

EXP

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

catalase

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cell division cycle and apoptosis regulator 1

increases expression

ISO

kojic acid results in increased expression of CCAR1 mRNA

NCBI chr20:31,228,624...31,271,233
Ensembl chr20:31,228,624...31,271,227

G

coiled-coil domain containing 144A

decreases expression

ISO

kojic acid results in decreased expression of CCDC144A mRNA

NCBI chr17:59,503,255...59,542,745
Ensembl chr17:59,503,243...59,542,741

G

coiled-coil domain containing 50

increases expression

ISO

kojic acid results in increased expression of CCDC50 mRNA

NCBI chr11:86,837,624...86,900,164
Ensembl chr11:86,837,624...86,899,980

G

C-C motif chemokine ligand 21

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCL21A mRNA

NCBI chr 5:61,776,411...61,777,515
Ensembl chr 5:61,776,413...61,777,540

G

C-C motif chemokine ligand 3

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

cyclin B1

increases expression

ISO

kojic acid results in increased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin C

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCNC mRNA

NCBI chr 5:40,063,589...40,081,731
Ensembl chr 5:40,063,623...40,093,370

G

cyclin D1

multiple interactions

EXP
ISO

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CCND1 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCND1 mRNA

PMID:17917374 PMID:18544905

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin G1

multiple interactions

EXP
ISO

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in increased expression of CCNG1 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CCNG1 mRNA

PMID:17917374 PMID:18544905

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

cell cycle progression 1

decreases expression

ISO

kojic acid results in decreased expression of CCPG1 mRNA

NCBI chr 8:82,600,677...82,633,082
Ensembl chr 8:82,600,536...82,660,246

G

C-C motif chemokine receptor 4

decreases expression

ISO

kojic acid results in decreased expression of CCR4 mRNA

NCBI chr 8:123,054,505...123,060,244
Ensembl chr 8:123,054,324...123,077,642

G

CD22 molecule

decreases expression

ISO

kojic acid results in decreased expression of CD22 mRNA

NCBI chr 1:95,243,785...95,270,430
Ensembl chr 1:95,244,868...95,259,730

G

CD274 molecule

increases expression

ISO

kojic acid results in increased expression of CD274 mRNA

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951

G

CD3 gamma subunit of T-cell receptor complex

decreases expression

ISO

kojic acid results in decreased expression of CD3G mRNA

NCBI chr 8:54,177,572...54,184,087
Ensembl chr 8:54,177,977...54,183,918

G

CDAN1 interacting nuclease 1

increases expression

ISO

kojic acid results in increased expression of CDIN1 mRNA

NCBI chr 3:122,895,754...123,101,099
Ensembl chr 3:122,895,824...123,101,099

G

cyclin-dependent kinase 10

decreases expression

ISO

kojic acid results in decreased expression of CDK10 mRNA

NCBI chr19:68,168,040...68,184,923
Ensembl chr19:68,169,874...68,177,599

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO
EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CDKN1A mRNA
[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CDKN1A mRNA

PMID:17917374 PMID:18544905

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

EXP

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA; [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

CEA cell adhesion molecule 1

decreases expression

ISO

kojic acid results in decreased expression of CEACAM1 mRNA

NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798

G

CCAAT/enhancer binding protein delta

increases expression

ISO

kojic acid results in increased expression of CEBPD mRNA

NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824

G

centromere protein Q

decreases expression

ISO

kojic acid results in decreased expression of CENPQ mRNA

NCBI chr 9:27,454,339...27,469,371
Ensembl chr 9:27,454,252...27,469,366

G

centrosomal protein 192

increases expression

ISO

kojic acid results in increased expression of CEP192 mRNA

NCBI chr18:63,643,816...63,728,264
Ensembl chr18:63,646,163...63,728,264

G

centrosomal protein 72

increases expression

ISO

kojic acid results in increased expression of CEP72 mRNA

NCBI chr 1:31,053,884...31,083,863
Ensembl chr 1:31,053,914...31,083,863

G

carboxylesterase 1D

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CES1 mRNA

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

checkpoint kinase 2

multiple interactions

EXP

[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CHEK2 mRNA; Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CHEK2 mRNA]

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

carbohydrate sulfotransferase 4

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CHST4 mRNA

NCBI chr19:54,900,914...54,911,735
Ensembl chr19:54,882,719...54,916,648

G

CBY1 interacting BAR domain containing 1

increases expression

ISO

kojic acid results in increased expression of CIBAR1 mRNA

NCBI chr 5:30,411,325...30,429,770
Ensembl chr 5:30,410,511...30,429,893

G

claudin 3

decreases expression

ISO

kojic acid results in decreased expression of CLDN3 mRNA

NCBI chr12:27,345,075...27,346,547
Ensembl chr12:27,345,076...27,348,841

G

claudin domain containing 2

decreases expression

ISO

kojic acid results in decreased expression of CLDND2 mRNA

NCBI chr 1:102,985,122...102,988,010
Ensembl chr 1:102,985,122...102,987,808

G

C-type lectin domain family 4, member B2

decreases expression

ISO

kojic acid results in decreased expression of CLEC4C mRNA

NCBI chr 4:158,148,434...158,171,933
Ensembl chr 4:158,148,314...158,172,249

G

CXADR-like membrane protein

decreases expression

ISO

kojic acid results in decreased expression of CLMP mRNA

NCBI chr 8:49,957,639...50,065,959
Ensembl chr 8:49,957,720...50,065,959

G

clusterin

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CLU mRNA

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

cornichon family member 1

increases expression

ISO

kojic acid results in increased expression of CNIH1 mRNA

NCBI chr15:22,517,755...22,529,651
Ensembl chr15:22,497,340...22,529,578

G

connector enhancer of kinase suppressor of Ras 2

decreases expression

ISO

kojic acid results in decreased expression of CNKSR2 mRNA

NCBI chr X:40,722,843...40,971,730
Ensembl chr X:40,722,996...40,965,604

G

collagen type XVII alpha 1 chain

decreases expression

ISO

kojic acid results in decreased expression of COL17A1 mRNA

NCBI chr 1:256,472,648...256,518,857
Ensembl chr 1:256,472,648...256,518,851

G

collagen type XXIV alpha 1 chain

decreases expression

ISO

kojic acid results in decreased expression of COL24A1 mRNA

NCBI chr 2:236,872,583...237,129,768
Ensembl chr 2:236,872,265...237,129,447

G

collagen like tail subunit of asymmetric acetylcholinesterase

increases expression

ISO

kojic acid results in increased expression of COLQ mRNA

NCBI chr16:6,738,251...6,830,492
Ensembl chr16:6,738,251...6,793,501

G

catechol-O-methyltransferase

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of COMT mRNA

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

COP9 signalosome subunit 2

decreases expression

ISO

kojic acid results in decreased expression of COPS2 mRNA

NCBI chr 3:133,537,729...133,563,493
Ensembl chr 3:133,537,732...133,563,369

G

coenzyme Q10A

increases expression

ISO

kojic acid results in increased expression of COQ10A mRNA

NCBI chr 7:1,376,591...1,387,694
Ensembl chr 7:1,376,591...1,382,722

G

coenzyme Q8A

increases expression

ISO

kojic acid results in increased expression of COQ8A mRNA

NCBI chr13:94,436,680...94,465,535
Ensembl chr13:94,436,546...94,463,378

G

carboxypeptidase B1

decreases expression

ISO

kojic acid results in decreased expression of CPB1 mRNA

NCBI chr 2:104,684,275...104,744,824
Ensembl chr 2:104,684,275...104,714,662

G

carboxypeptidase E

increases expression

ISO

kojic acid results in increased expression of CPE mRNA

NCBI chr16:29,796,707...29,908,647
Ensembl chr16:29,796,689...29,909,524

G

copine 5

increases expression

ISO

kojic acid results in increased expression of CPNE5 mRNA

NCBI chr20:7,208,389...7,290,959
Ensembl chr20:7,208,389...7,292,064

G

cAMP responsive element binding protein 1

decreases phosphorylation

ISO

kojic acid results in decreased phosphorylation of CREB1 protein

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

chromosome segregation 1 like

decreases expression

ISO

kojic acid results in decreased expression of CSE1L mRNA

NCBI chr 3:176,060,183...176,097,909
Ensembl chr 3:176,060,215...176,108,734

G

catenin alpha-like 1

decreases expression

ISO

kojic acid results in decreased expression of CTNNAL1 mRNA

NCBI chr 5:76,309,546...76,375,869
Ensembl chr 5:76,309,546...76,364,637

G

cathepsin Z

increases expression

ISO

kojic acid results in increased expression of CTSZ mRNA

NCBI chr 3:183,643,077...183,653,847
Ensembl chr 3:183,643,077...183,657,012

G

cytochrome b5 reductase 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYB5R3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYB5R3 mRNA

NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:116,186,729...116,204,306

G

cytochrome P450, family 26, subfamily b, polypeptide 1

increases expression

ISO

kojic acid results in increased expression of CYP26B1 mRNA

NCBI chr 4:118,599,356...118,616,176
Ensembl chr 4:118,599,356...118,616,176

G

cytochrome P450, family 2, subfamily b, polypeptide 15

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2B15 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP2B15 mRNA

NCBI chr 1:91,221,865...91,234,169
Ensembl chr 1:91,221,865...91,234,169

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP2B10 mRNA

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2C mRNA

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 2, subfamily c, polypeptide 13

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2C13 mRNA

NCBI chr 1:248,706,787...248,787,239
Ensembl chr 1:248,706,788...248,787,210

G

cytochrome P450, family 2, subfamily c, polypeptide 22

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2C70 mRNA

NCBI chr 1:248,941,143...248,980,767
Ensembl chr 1:248,904,062...248,971,182

G

cytochrome P450, family 2, subfamily c, polypeptide 7

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2C7 mRNA

NCBI chr 1:247,966,295...248,022,393
Ensembl chr 1:247,966,346...248,022,388

G

cytochrome P450, family 2, subfamily d, polypeptide 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2D13 mRNA

NCBI chr 7:115,797,785...115,802,142
Ensembl chr 7:115,797,789...115,802,158

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP2D22 mRNA

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 2, subfamily f, polypeptide 4

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2F2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP2F2 mRNA

NCBI chr 1:91,543,768...91,557,553
Ensembl chr 1:91,543,768...91,557,553

G

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4A22 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP4A22 mRNA

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231

G

cytochrome P450, family 4, subfamily b, polypeptide 1

multiple interactions

ISO
EXP

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CYP4B1 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNA

PMID:17917374 PMID:18544905

NCBI chr 5:134,375,807...134,413,635
Ensembl chr 5:134,375,807...134,393,116

G

cytochrome P450, family 4, subfamily f, polypeptide 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4F2 mRNA

NCBI chr 7:12,661,357...12,672,952
Ensembl chr 7:12,661,359...12,672,612

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytochrome P450 family 8 subfamily B member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP8B1 mRNA

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689

G

cytohesin 3

increases expression

ISO

kojic acid results in increased expression of CYTH3 mRNA

NCBI chr12:15,953,781...16,076,584
Ensembl chr12:15,953,791...16,047,506

G

cytohesin 1 interacting protein

increases expression

ISO

kojic acid results in increased expression of CYTIP mRNA

NCBI chr 3:63,106,895...63,183,769
Ensembl chr 3:63,107,607...63,134,832

G

diacylglycerol lipase, alpha

increases expression

ISO

kojic acid results in increased expression of DAGLA mRNA

NCBI chr 1:216,315,515...216,372,219
Ensembl chr 1:216,315,516...216,372,111

G

DAZ associated protein 2

increases expression

ISO

kojic acid results in increased expression of DAZAP2 mRNA

NCBI chr 7:133,593,503...133,599,044
Ensembl chr 7:133,593,512...133,599,047

G

DDB1 and CUL4 associated factor 13

decreases expression

ISO

kojic acid results in decreased expression of DCAF13 mRNA

NCBI chr 7:72,045,828...72,081,039
Ensembl chr 7:72,045,872...72,083,629

G

dopachrome tautomerase

decreases expression

ISO

kojic acid results in decreased expression of DCT protein

NCBI chr15:101,469,159...101,508,029
Ensembl chr15:101,469,159...101,508,029

G

DNA-damage inducible transcript 3

multiple interactions

EXP

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DEK proto-oncogene

decreases expression

ISO

kojic acid results in decreased expression of DEK mRNA

NCBI chr17:17,786,989...17,809,096
Ensembl chr17:17,787,139...17,810,122

G

DLG associated protein 4

increases expression

ISO

kojic acid results in increased expression of DLGAP4 mRNA

NCBI chr 3:165,584,271...165,731,868
Ensembl chr 3:165,584,360...165,730,604

G

distal-less homeobox 1

decreases expression

ISO

kojic acid results in decreased expression of DLX1 mRNA

NCBI chr 3:76,763,864...76,768,454
Ensembl chr 3:76,763,500...76,768,447

G

Dmx-like 1

decreases expression

ISO

kojic acid results in decreased expression of DMXL1 mRNA

NCBI chr18:45,179,505...45,349,999
Ensembl chr18:45,179,551...45,356,406

G

DnaJ heat shock protein family (Hsp40) member A1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of DNAJA1 mRNA

NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:60,638,410...60,650,160

G

DnaJ heat shock protein family (Hsp40) member A2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of DNAJA2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of DNAJA2 mRNA

NCBI chr19:37,671,019...37,689,163
Ensembl chr19:37,670,945...37,690,120

G

deoxynucleotidyltransferase, terminal, interacting protein 2

decreases expression

ISO

kojic acid results in decreased expression of DNTTIP2 mRNA

NCBI chr 2:213,058,975...213,071,020
Ensembl chr 2:213,058,962...213,071,016

G

dedicator of cytokinesis 4

increases expression

ISO

kojic acid results in increased expression of DOCK4 mRNA

NCBI chr 6:63,240,050...63,629,772
Ensembl chr 6:63,240,136...63,629,772

G

docking protein 4

decreases expression

ISO

kojic acid results in decreased expression of DOK4 mRNA

NCBI chr19:10,152,511...10,163,182
Ensembl chr19:10,152,458...10,164,190

G

dihydropyrimidine dehydrogenase

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of DPYD mRNA

NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:209,293,929...210,159,778

G

dentin sialophosphoprotein

decreases expression

ISO

kojic acid results in decreased expression of DSPP mRNA

NCBI chr14:5,870,232...5,876,339
Ensembl chr14:5,870,232...5,876,339

G

destrin, actin depolymerizing factor

increases expression

ISO

kojic acid results in increased expression of DSTN mRNA

NCBI chr 3:151,737,711...151,764,752
Ensembl chr 3:151,737,849...151,764,769

G

dynein light chain Tctex-type 3

decreases expression

ISO

kojic acid results in decreased expression of DYNLT3 mRNA

NCBI chr X:16,000,425...16,009,632
Ensembl chr X:16,000,395...16,009,627

G

E2F transcription factor 3

increases expression

ISO

kojic acid results in increased expression of E2F3 mRNA

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725

G

E2F transcription factor 8

increases expression

ISO

kojic acid results in increased expression of E2F8 mRNA

NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:107,701,985...107,720,009

G

ephrin A3

decreases expression

ISO

kojic acid results in decreased expression of EFNA3 mRNA

NCBI chr 2:177,026,928...177,035,838
Ensembl chr 2:177,026,933...177,044,843

G

early growth response 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

eukaryotic translation initiation factor 4E

decreases expression

ISO

kojic acid results in decreased expression of EIF4E mRNA

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:229,739,897...229,774,105

G

eukaryotic translation initiation factor 5A2

increases expression

ISO

kojic acid results in increased expression of EIF5A2 mRNA

NCBI chr 2:113,656,748...113,674,598
Ensembl chr 2:113,657,797...113,674,594

G

elastase, neutrophil expressed

decreases expression

ISO

kojic acid results in decreased expression of ELANE mRNA

NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:10,467,877...10,469,725

G

E1A binding protein p300

increases expression

ISO

kojic acid results in increased expression of EP300 mRNA

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

EPH receptor A10

decreases expression

ISO

kojic acid results in decreased expression of EPHA10 mRNA

NCBI chr 5:142,424,260...142,460,305
Ensembl chr 5:142,424,296...142,460,305

G

Eph receptor A4

increases expression

ISO

kojic acid results in increased expression of EPHA4 mRNA

NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755

G

epoxide hydrolase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of EPHX1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981

G

epoxide hydrolase 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of EPHX2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of EPHX2 mRNA

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160

G

ERCC excision repair 2, TFIIH core complex helicase subunit

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC2 mRNA

NCBI chr 1:88,161,342...88,175,102
Ensembl chr 1:88,160,988...88,175,102

G

ERCC excision repair 3, TFIIH core complex helicase subunit

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of ERCC3 mRNA

NCBI chr18:24,157,831...24,188,543
Ensembl chr18:24,148,084...24,190,898

G

ERCC excision repair 4, endonuclease catalytic subunit

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC4 mRNA

NCBI chr10:2,926,085...2,958,176
Ensembl chr10:2,920,455...2,955,539

G

ERCC excision repair 5, endonuclease

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC5 mRNA

NCBI chr 9:53,801,471...53,846,611
Ensembl chr 9:53,801,714...53,875,084

G

endothelial cell adhesion molecule

increases expression

ISO

kojic acid results in increased expression of ESAM mRNA

NCBI chr 8:45,426,985...45,437,976
Ensembl chr 8:45,425,731...45,437,973

G

epithelial splicing regulatory protein 1

increases expression

ISO

kojic acid results in increased expression of ESRP1 mRNA

NCBI chr 5:29,224,831...29,279,381
Ensembl chr 5:29,225,360...29,279,278

G

exonuclease 3'-5' domain containing 1

decreases expression

ISO

kojic acid results in decreased expression of EXD1 mRNA

NCBI chr 3:126,961,800...126,989,738
Ensembl chr 3:126,961,896...126,989,738

G

exocyst complex component 2

increases expression

ISO

kojic acid results in increased expression of EXOC2 mRNA

NCBI chr17:33,714,949...33,906,901
Ensembl chr17:33,715,008...33,901,944

G

coagulation factor X

increases expression

ISO

kojic acid results in increased expression of F10 mRNA

NCBI chr16:83,170,973...83,190,280
Ensembl chr16:83,170,977...83,190,280

G

family with sequence similarity 241 member A

increases expression

ISO

kojic acid results in increased expression of FAM241A mRNA

NCBI chr 2:219,019,025...219,049,648
Ensembl chr 2:219,018,241...219,049,770

G

fibrillin 2

increases expression

ISO

kojic acid results in increased expression of FBN2 mRNA

NCBI chr18:53,696,197...53,901,992
Ensembl chr18:53,697,708...53,902,191

G

F-box protein 16

increases expression

ISO

kojic acid results in increased expression of FBXO16 mRNA

NCBI chr15:43,667,207...43,717,096
Ensembl chr15:43,667,855...43,734,346

G

FERRY endosomal RAB5 effector complex subunit 3

decreases expression

ISO

kojic acid results in decreased expression of FERRY3 mRNA

NCBI chr 4:161,458,942...161,494,213
Ensembl chr 4:161,458,931...161,493,075

G

fibroblast growth factor 12

increases expression

ISO

kojic acid results in increased expression of FGF12 mRNA

NCBI chr11:85,501,947...86,069,543
Ensembl chr11:85,501,936...86,069,543

G

fibroblast growth factor 5

decreases expression

ISO

kojic acid results in decreased expression of FGF5 mRNA

NCBI chr14:11,627,906...11,650,243
Ensembl chr14:11,627,906...11,650,243

G

fibroblast growth factor receptor 3

decreases expression

ISO

kojic acid results in decreased expression of FGFR3 mRNA

NCBI chr14:81,211,800...81,227,215
Ensembl chr14:81,211,800...81,227,209

G

fibrinogen C domain containing 1

decreases expression

ISO

kojic acid results in decreased expression of FIBCD1 mRNA

NCBI chr 3:35,490,459...35,524,142
Ensembl chr 3:35,490,459...35,524,142

G

FKBP prolyl isomerase 10

increases expression

ISO

kojic acid results in increased expression of FKBP10 mRNA

NCBI chr10:85,845,801...85,858,361
Ensembl chr10:85,844,703...85,858,355

G

flavin containing dimethylaniline monoxygenase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of FMO1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of FMO1 mRNA

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

fucose-1-phosphate guanylyltransferase

decreases expression

ISO

kojic acid results in decreased expression of FPGT mRNA

NCBI chr 2:246,757,982...246,778,896
Ensembl chr 2:246,757,986...246,778,848

G

FERM and PDZ domain containing 4

decreases expression

ISO

kojic acid results in decreased expression of FRMPD4 mRNA

NCBI chr X:29,739,834...30,386,917
Ensembl chr X:29,368,849...30,384,621

G

40S small subunit processome assembly factor 1

decreases expression

ISO

kojic acid results in decreased expression of FSAF1 mRNA

NCBI chr19:69,705,313...69,719,894
Ensembl chr19:69,705,321...69,720,093

G

ferritin heavy chain 1

increases expression

ISO

kojic acid results in increased expression of FTH1 mRNA; kojic acid results in increased expression of FTH1 protein

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

frizzled class receptor 8

increases expression

ISO

kojic acid results in increased expression of FZD8 mRNA

NCBI chr17:62,007,849...62,015,485
Ensembl chr17:62,007,627...62,015,961

G

growth arrest and DNA-damage-inducible, beta

multiple interactions

EXP

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

polypeptide N-acetylgalactosaminyltransferase 1

decreases expression

ISO

kojic acid results in decreased expression of GALNT1 mRNA

NCBI chr18:15,763,697...15,843,598
Ensembl chr18:15,764,277...15,843,588

G

Gfo/Idh/MocA-like oxidoreductase domain containing 1

decreases expression

ISO

kojic acid results in decreased expression of GFOD1 mRNA

NCBI chr17:21,606,090...21,710,922
Ensembl chr17:21,605,415...21,710,920

G

GLE1 RNA export mediator

decreases expression

ISO

kojic acid results in decreased expression of GLE1 mRNA

NCBI chr 3:33,607,160...33,638,879

G

guanosine monophosphate reductase

decreases expression

ISO

kojic acid results in decreased expression of GMPR mRNA

NCBI chr17:19,357,992...19,395,807
Ensembl chr17:19,357,992...19,431,655

G

G protein subunit beta 1

increases expression

ISO

kojic acid results in increased expression of GNB1 mRNA

NCBI chr 5:171,357,778...171,424,489
Ensembl chr 5:171,357,797...171,424,488

G

G protein-coupled receptor 146

decreases expression

ISO

kojic acid results in decreased expression of GPR146 mRNA

NCBI chr12:20,365,790...20,381,122
Ensembl chr12:20,364,269...20,381,345

G

G protein-coupled receptor 26

decreases expression

ISO

kojic acid results in decreased expression of GPR26 mRNA

NCBI chr 1:196,196,138...196,235,574
Ensembl chr 1:196,196,767...196,235,559

G

G protein-coupled receptor 32

increases expression

ISO

kojic acid results in increased expression of GPR32 mRNA

NCBI chr 1:103,893,405...103,894,667

G

G protein-coupled receptor 61

decreases expression

ISO

kojic acid results in decreased expression of GPR61 mRNA

NCBI chr 2:198,471,430...198,477,827
Ensembl chr 2:198,427,135...198,477,874

G

glutathione peroxidase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GPX1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

gasdermin A

decreases expression

ISO

kojic acid results in decreased expression of GSDMA mRNA

NCBI chr10:84,110,590...84,135,804
Ensembl chr10:84,123,314...84,135,804

G

glutathione-disulfide reductase

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTA2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTA2 mRNA

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092

G

glutathione S-transferase alpha 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTA3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTA3 mRNA

NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654

G

glutathione S-transferase alpha 4

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTA4 mRNA

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488

G

glutathione S-transferase mu 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM1 mRNA

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase mu 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM2 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase, mu 5

multiple interactions

ISO
EXP

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM3 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM3 mRNA

PMID:17917374 PMID:18544905

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731

G

guanylate cyclase 1 soluble subunit alpha 2

decreases expression

ISO

kojic acid results in decreased expression of GUCY1A2 mRNA

NCBI chr 8:8,785,212...9,174,322
Ensembl chr 8:8,785,121...9,174,272

G

H1.1 linker histone, cluster member

increases expression

ISO

kojic acid results in increased expression of H1-1 mRNA

NCBI chr17:41,762,278...41,794,876

G

H2A clustered histone 6

increases expression

ISO

kojic acid results in increased expression of H2AC6 mRNA

NCBI chr17:47,403,701...47,404,167

G

heart and neural crest derivatives expressed 1

increases expression

ISO

kojic acid results in increased expression of HAND1 mRNA

NCBI chr10:42,507,117...42,509,684
Ensembl chr10:42,507,122...42,509,684

G

harbinger transposase derived 1

decreases expression

ISO

kojic acid results in decreased expression of HARBI1 mRNA

NCBI chr 3:98,137,087...98,145,992
Ensembl chr 3:98,137,123...98,146,315

G

3-hydroxyisobutyryl-CoA hydrolase

decreases expression

ISO

kojic acid results in decreased expression of HIBCH mRNA

NCBI chr 9:56,082,082...56,161,796
Ensembl chr 9:56,082,091...56,161,886

G

histidine triad nucleotide binding protein 3

increases expression

ISO

kojic acid results in increased expression of HINT3 mRNA

NCBI chr 1:28,854,860...28,864,723
Ensembl chr 1:28,854,844...28,867,125

G

huntingtin interacting protein 1

increases expression

ISO

kojic acid results in increased expression of HIP1 mRNA

NCBI chr12:26,769,868...26,904,367
Ensembl chr12:26,769,961...26,904,296

G

HLF transcription factor, PAR bZIP family member

decreases expression

ISO

kojic acid results in decreased expression of HLF mRNA

NCBI chr10:75,651,320...75,708,979
Ensembl chr10:75,654,534...75,708,619

G

hyaluronan-mediated motility receptor

decreases expression

ISO

kojic acid results in decreased expression of HMMR mRNA

NCBI chr10:25,635,249...25,665,389
Ensembl chr10:25,635,915...25,665,390

G

heme oxygenase 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HMOX2 mRNA

NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800

G

heterogeneous nuclear ribonucleoprotein H2

increases expression

ISO

kojic acid results in increased expression of HNRNPH2 mRNA

NCBI chr X:102,074,175...102,080,115
Ensembl chr X:102,074,179...102,081,025

G

HPS3, biogenesis of lysosomal organelles complex 2 subunit 1

decreases expression

ISO

kojic acid results in decreased expression of HPS3 mRNA

NCBI chr 2:104,413,618...104,455,091
Ensembl chr 2:104,413,417...104,455,091

G

heat shock protein 90 alpha family class A member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSP90AA1 mRNA

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein 90 alpha family class B member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSP90AB1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPA1A mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 5

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family B (small) member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPB1 mRNA

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family D (Hsp60) member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPD1 mRNA

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

heat shock protein family E (Hsp10) member 1

multiple interactions

EXP
ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HSPE1 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of HSPE1 mRNA

PMID:17917374 PMID:18544905

NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:64,085,068...64,087,502

G

hypoxia up-regulated 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of HYOU1 mRNA

NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:53,602,604...53,614,997

G

insulin-like growth factor 2 receptor

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of IGF2R mRNA

NCBI chr 1:50,526,878...50,615,265
Ensembl chr 1:50,526,878...50,615,265

G

interleukin 1 alpha

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor-like 1

increases expression

ISO

kojic acid results in increased expression of IL1RL1 mRNA

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891

G

interleukin 22 receptor subunit alpha 1

increases expression

ISO

kojic acid results in increased expression of IL22RA1 mRNA

NCBI chr 5:153,245,067...153,269,865
Ensembl chr 5:153,245,002...153,271,683

G

interleukin 6

decreases expression

ISO

kojic acid results in decreased expression of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 cytokine family signal transducer

decreases expression

ISO

kojic acid results in decreased expression of IL6ST mRNA

NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182

G

inner centromere protein

increases expression

ISO

kojic acid results in increased expression of INCENP mRNA

NCBI chr 1:215,945,558...216,017,247
Ensembl chr 1:215,948,283...215,977,084

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

kojic acid results in increased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

lysyl-tRNA synthetase 1

decreases expression

ISO

kojic acid results in decreased expression of KARS1 mRNA

NCBI chr19:56,867,096...56,886,151
Ensembl chr19:56,867,096...56,886,073

G

potassium voltage-gated channel subfamily A regulatory beta subunit 3

decreases expression

ISO

kojic acid results in decreased expression of KCNAB3 mRNA

NCBI chr10:54,546,638...54,555,209
Ensembl chr10:54,546,618...54,553,357

G

potassium channel tetramerization domain containing 17

decreases expression

ISO

kojic acid results in decreased expression of KCTD17 mRNA

NCBI chr 7:111,859,556...111,891,869
Ensembl chr 7:111,859,256...111,870,692

G

lysine demethylase 4D

increases expression

ISO

kojic acid results in increased expression of KDM4D mRNA

NCBI chr 8:19,561,253...19,586,412
Ensembl chr 8:19,548,676...19,587,331

G

KLF transcription factor 5

increases expression

ISO

kojic acid results in increased expression of KLF5 mRNA

NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262

G

kelch-like family member 13

increases expression

ISO

kojic acid results in increased expression of KLHL13 mRNA

NCBI chr X:118,747,298...118,912,279
Ensembl chr X:118,747,298...118,855,035

G

kallikrein B1

decreases expression

ISO

kojic acid results in decreased expression of KLKB1 mRNA

NCBI chr16:53,690,180...53,714,570
Ensembl chr16:53,691,220...53,716,339

G

keratin 7

increases expression

ISO

kojic acid results in increased expression of KRT7 mRNA

NCBI chr 7:134,407,626...134,423,787
Ensembl chr 7:134,407,584...134,423,786

G

kinectin 1

decreases expression

ISO

kojic acid results in decreased expression of KTN1 mRNA

NCBI chr15:23,392,570...23,485,061
Ensembl chr15:23,394,315...23,482,263

G

La ribonucleoprotein 7, transcriptional regulator

decreases expression

ISO

kojic acid results in decreased expression of LARP7 mRNA

NCBI chr 2:218,672,145...218,687,332
Ensembl chr 2:218,672,208...218,687,308

G

leukocyte immunoglobulin like receptor B3

decreases expression

ISO

kojic acid results in decreased expression of LILRB5 mRNA

NCBI chr 1:79,001,483...79,011,054
Ensembl chr 1:79,001,600...79,010,981

G

LDL receptor related protein 6

decreases expression

ISO

kojic acid results in decreased expression of LRP6 mRNA

NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:169,000,968...169,131,716

G

leucine rich repeat containing 4

decreases expression

ISO

kojic acid results in decreased expression of LRRC4 mRNA

NCBI chr 4:58,398,942...58,402,538
Ensembl chr 4:58,397,302...58,402,808

G

leucine rich repeat containing 9

increases expression

ISO

kojic acid results in increased expression of LRRC9 mRNA

NCBI chr 6:96,746,972...96,831,840
Ensembl chr 6:96,761,246...96,845,259

G

macrophage erythroblast attacher, E3 ubiquitin ligase

increases expression

ISO

kojic acid results in increased expression of MAEA mRNA

NCBI chr14:81,581,784...81,615,246
Ensembl chr14:81,581,785...81,615,202

G

MAF bZIP transcription factor K

decreases expression

ISO

kojic acid results in decreased expression of MAFK mRNA

NCBI chr12:19,948,473...19,970,351
Ensembl chr12:19,948,476...19,959,192

G

MAGE family member C2

increases expression

ISO

kojic acid results in increased expression of MAGEC2 mRNA

NCBI chr X:145,646,856...145,651,730
Ensembl chr X:145,646,830...145,651,721

G

monoamine oxidase A

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOA mRNA

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MAOB mRNA

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

MAP7 domain containing 2

decreases expression

ISO

kojic acid results in decreased expression of MAP7D2 mRNA

NCBI chr X:39,181,091...39,296,814
Ensembl chr X:39,181,091...39,296,695

G

mitogen activated protein kinase 1

decreases phosphorylation

ISO

kojic acid results in decreased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

decreases phosphorylation

ISO

kojic acid results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

decreases expression

ISO

kojic acid results in decreased expression of MAPK8 mRNA

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

muscleblind-like splicing regulator 1

decreases expression

ISO

kojic acid results in decreased expression of MBNL1 mRNA

NCBI chr 2:146,789,570...146,964,136
Ensembl chr 2:146,789,596...146,964,134

G

melanocortin 1 receptor

decreases expression
increases expression

ISO

kojic acid results in decreased expression of MC1R protein
kojic acid results in increased expression of MC1R protein

PMID:23738040 PMID:27586645

NCBI chr19:68,360,950...68,363,877
Ensembl chr19:68,360,950...68,363,877

G

MyoD family inhibitor

decreases expression

ISO

kojic acid results in decreased expression of MDFI mRNA

NCBI chr 9:20,654,359...20,672,768
Ensembl chr 9:20,654,417...20,672,767

G

MDM2 proto-oncogene

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

malic enzyme 3

decreases expression

ISO

kojic acid results in decreased expression of ME3 mRNA

NCBI chr 1:152,946,595...153,148,026
Ensembl chr 1:152,946,628...153,148,026

G

mediator complex subunit 14

increases expression

ISO

kojic acid results in increased expression of MED14 mRNA

NCBI chr X:12,709,406...12,800,642
Ensembl chr X:12,709,472...12,800,640

G

mex-3 RNA binding family member B

increases expression

ISO

kojic acid results in increased expression of MEX3B mRNA

NCBI chr 1:146,264,319...146,268,554
Ensembl chr 1:146,264,318...146,268,543

G

microfibril associated protein 4

decreases expression

ISO

kojic acid results in decreased expression of MFAP4 mRNA

NCBI chr10:46,666,552...46,669,613
Ensembl chr10:46,655,722...46,669,740

G

O-6-methylguanine-DNA methyltransferase

multiple interactions

EXP

[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA; Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA]

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

microsomal glutathione S-transferase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MGST1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MGST1 mRNA

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

midnolin

decreases expression

ISO

kojic acid results in decreased expression of MIDN mRNA

NCBI chr 7:10,198,761...10,210,563
Ensembl chr 7:10,200,306...10,207,203

G

macrophage migration inhibitory factor

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MIF mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of MIF mRNA

NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121

G

meiotic nuclear divisions 1

increases expression

ISO

kojic acid results in increased expression of GAJ mRNA

NCBI chr 2:171,731,523...171,794,124
Ensembl chr 2:171,731,523...171,794,095

G

mitochondrial ribosomal protein L30

decreases expression

ISO

kojic acid results in decreased expression of MRPL30 mRNA

NCBI chr 9:47,621,226...47,631,986
Ensembl chr 9:47,621,227...47,633,484

G

mitochondrially encoded cytochrome c oxidase I

increases expression

ISO

kojic acid results in increased expression of COX1 mRNA; kojic acid results in increased expression of COX1 protein

NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853

G

Mtr4 exosome RNA helicase

decreases expression

ISO

kojic acid results in decreased expression of MTREX mRNA

NCBI chr 2:46,233,528...46,293,827
Ensembl chr 2:46,194,647...46,293,827

G

major vault protein

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MVP mRNA

NCBI chr 1:191,025,259...191,052,866
Ensembl chr 1:191,025,268...191,052,873

G

N(alpha)-acetyltransferase 25, NatB auxiliary subunit

increases expression

ISO

kojic acid results in increased expression of NAA25 mRNA

NCBI chr12:40,758,909...40,811,192
Ensembl chr12:40,758,728...40,811,291

G

neurocalcin delta

decreases expression

ISO

kojic acid results in decreased expression of NCALD mRNA

NCBI chr 7:70,417,683...70,849,763
Ensembl chr 7:70,419,433...70,849,482

G

NADH:ubiquinone oxidoreductase subunit A1

increases expression

ISO

kojic acid results in increased expression of NDUFA1 mRNA

NCBI chr X:121,289,904...121,293,555
Ensembl chr X:121,289,925...121,293,555

G

nectin cell adhesion molecule 4

increases expression

ISO

kojic acid results in increased expression of NECTIN4 mRNA

NCBI chr13:86,335,027...86,354,152
Ensembl chr13:86,335,831...86,353,967

G

nuclear factor, interleukin 3 regulated

increases expression

ISO

kojic acid results in increased expression of NFIL3 mRNA

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826

G

NFKB inhibitor alpha

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of NFKBIA mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of NFKBIA mRNA

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor epsilon

increases expression

ISO

kojic acid results in increased expression of NFKBIE mRNA

NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:22,941,040...22,947,872

G

NK6 homeobox 1

decreases expression

ISO

kojic acid results in decreased expression of NKX6-1 mRNA

NCBI chr14:8,274,238...8,281,171
Ensembl chr14:8,274,238...8,281,163

G

neuroligin 2

decreases expression

ISO

kojic acid results in decreased expression of NLGN2 mRNA

NCBI chr10:55,042,175...55,056,578
Ensembl chr10:55,043,185...55,056,578

G

NOC3-like DNA replication regulator

decreases expression

ISO

kojic acid results in decreased expression of NOC3L mRNA

NCBI chr 1:245,969,179...245,997,761
Ensembl chr 1:245,969,179...245,997,708

G

nucleolar protein 11

decreases expression

ISO

kojic acid results in decreased expression of NOL11 mRNA

NCBI chr10:92,621,482...92,641,394
Ensembl chr10:92,621,498...92,641,394

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of NR1I2 mRNA

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of NR1I3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of NR1I3 mRNA

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

outer dynein arm docking complex subunit 2

increases expression

ISO

kojic acid results in increased expression of ODAD2 mRNA

NCBI chr17:59,910,665...60,104,929
Ensembl chr17:59,910,757...60,103,547

G

olfactomedin-like 1

decreases expression

ISO

kojic acid results in decreased expression of OLFML1 mRNA

NCBI chr 1:170,889,912...170,914,300
Ensembl chr 1:170,889,980...170,915,762

G

olfactory receptor family 51 subfamily B member 4

decreases expression

ISO

kojic acid results in decreased expression of OR51B4 mRNA

NCBI chr 1:167,729,117...167,730,040
Ensembl chr 1:167,729,117...167,730,040

G

oxysterol binding protein 2

decreases expression

ISO

kojic acid results in decreased expression of OSBP2 mRNA

NCBI chr14:82,808,693...82,970,386
Ensembl chr14:82,808,693...82,970,532

G

osteoclastogenesis associated transmembrane protein 1

decreases expression

ISO

kojic acid results in decreased expression of OSTM1 mRNA

NCBI chr20:47,653,696...47,769,248
Ensembl chr20:47,653,670...47,769,237

G

orthodenticle homeobox 1

increases expression

ISO

kojic acid results in increased expression of OTX1 mRNA

NCBI chr14:100,283,406...100,290,421
Ensembl chr14:100,283,406...100,290,421

G

PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1

increases expression

ISO

kojic acid results in increased expression of PABIR1 mRNA

NCBI chr 1:231,541,411...231,542,717
Ensembl chr 1:231,537,357...231,612,411

G

Paxip1-associated glutamate-rich protein 1

increases expression

ISO

kojic acid results in increased expression of PAGR1 mRNA

NCBI chr 1:191,053,228...191,055,554

G

phenylalanine hydroxylase

decreases expression

ISO

kojic acid results in decreased expression of PAH mRNA

NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:23,792,781...23,885,627

G

poly (ADP-ribose) glycohydrolase

increases expression

ISO

kojic acid results in increased expression of PARG mRNA

NCBI chr16:7,442,696...7,550,585
Ensembl chr16:7,442,726...7,550,584

G

PDZ binding kinase

decreases expression

ISO

kojic acid results in decreased expression of PBK mRNA

NCBI chr15:44,198,506...44,209,572
Ensembl chr15:44,198,544...44,209,570

G

proliferating cell nuclear antigen

multiple interactions

ISO
EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of PCNA protein
[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in increased expression of PCNA protein

PMID:17917374 PMID:18544905

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

pecanex 3

decreases expression

ISO

kojic acid results in decreased expression of PCNX3 mRNA

NCBI chr 1:212,380,657...212,402,967
Ensembl chr 1:212,379,851...212,403,166

G

proprotein convertase subtilisin/kexin type 4

decreases expression

ISO

kojic acid results in decreased expression of PCSK4 mRNA

NCBI chr 7:10,032,040...10,040,263
Ensembl chr 7:10,031,988...10,040,255

G

phosducin like

increases expression

ISO

kojic acid results in increased expression of PDCL mRNA

NCBI chr 3:41,519,953...41,529,545
Ensembl chr 3:41,519,954...41,527,794
Ensembl chr 3:41,519,954...41,527,794

G

pyruvate dehydrogenase E1 subunit alpha 1

increases expression

ISO

kojic acid results in increased expression of PDHA1 mRNA

NCBI chr X:38,509,158...38,522,986
Ensembl chr X:38,509,084...38,522,536

G

protein disulfide isomerase family A, member 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PDIA3 mRNA

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

PDZ and LIM domain 2

increases expression

ISO

kojic acid results in increased expression of PDLIM2 mRNA

NCBI chr15:51,647,195...51,659,904
Ensembl chr15:51,647,197...51,658,958

G

PPARGC1 and ESRR induced regulator, muscle 1

decreases expression

ISO

kojic acid results in decreased expression of PERM1 mRNA

NCBI chr 5:172,082,249...172,087,542
Ensembl chr 5:172,082,249...172,087,542

G

peroxisomal biogenesis factor 5-like

decreases expression

ISO

kojic acid results in decreased expression of PEX5L mRNA

NCBI chr 2:117,623,199...117,836,772
Ensembl chr 2:117,623,199...117,836,685

G

phosphoglucomutase 2

increases expression

ISO

kojic acid results in increased expression of PGM2 mRNA

NCBI chr14:44,519,906...44,553,420
Ensembl chr14:44,519,906...44,553,770

G

phosphatidylinositol glycan anchor biosynthesis, class Q

decreases expression

ISO

kojic acid results in decreased expression of PIGQ mRNA

NCBI chr10:15,447,080...15,463,088
Ensembl chr10:15,447,081...15,463,088

G

phosphatidylinositol transfer protein, beta

increases expression

ISO

kojic acid results in increased expression of PITPNB mRNA

NCBI chr12:50,909,140...50,958,193
Ensembl chr12:50,909,143...50,958,140

G

PLAG1 like zinc finger 1

increases expression

ISO

kojic acid results in increased expression of PLAGL1 mRNA

NCBI chr 1:9,297,066...9,337,394
Ensembl chr 1:9,330,204...9,337,394

G

protein O-glucosyltransferase 2

increases expression

ISO

kojic acid results in increased expression of POGLUT2 mRNA

NCBI chr 9:53,748,484...53,801,453
Ensembl chr 9:53,740,998...53,760,588

G

paraoxonase 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PON3 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of PON3 mRNA

NCBI chr 4:34,323,546...34,350,244
Ensembl chr 4:34,315,889...34,350,244

G

cytochrome p450 oxidoreductase

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of POR mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of POR mRNA

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

POU class 2 homeobox 3

decreases expression

ISO

kojic acid results in decreased expression of POU2F3 mRNA

NCBI chr 8:52,392,363...52,474,756
Ensembl chr 8:52,392,497...52,474,756

G

protein phosphatase 4, regulatory subunit 1

increases expression

ISO

kojic acid results in increased expression of PPP4R1 mRNA

NCBI chr 9:112,836,950...112,897,490
Ensembl chr 9:112,838,812...112,897,557

G

peroxiredoxin 1

multiple interactions

EXP

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PRDX1 mRNA

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

peroxiredoxin 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PRDX2 mRNA

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

proteoglycan 2, pro eosinophil major basic protein

decreases expression

ISO

kojic acid results in decreased expression of PRG2 mRNA

NCBI chr 3:90,469,192...90,472,759
Ensembl chr 3:90,469,176...90,472,752

G

prickle planar cell polarity protein 3

decreases expression

ISO

kojic acid results in decreased expression of PRICKLE3 mRNA

NCBI chr X:17,509,551...17,520,157
Ensembl chr X:17,509,554...17,520,122

G

DNA primase subunit 1

decreases expression

ISO

kojic acid results in decreased expression of PRIM1 mRNA

NCBI chr 7:1,031,436...1,047,134

G

protein arginine methyltransferase 2

decreases expression

ISO

kojic acid results in decreased expression of PRMT2 mRNA

NCBI chr20:12,391,388...12,420,096
Ensembl chr20:12,394,268...12,420,108

G

pre-mRNA processing factor 40 homolog A

decreases expression

ISO

kojic acid results in decreased expression of PRPF40A mRNA

NCBI chr 3:58,036,779...58,098,996
Ensembl chr 3:58,038,042...58,099,363

G

phosphoribosyl pyrophosphate synthetase 2

increases expression

ISO

kojic acid results in increased expression of PRPS2 mRNA

NCBI chr X:30,592,845...30,630,127
Ensembl chr X:30,593,019...30,630,126

G

proline rich 18

decreases expression

ISO

kojic acid results in decreased expression of PRR18 mRNA

NCBI chr 1:54,947,775...54,951,558
Ensembl chr 1:54,947,351...54,959,997

G

proline-rich coiled-coil 2C

increases expression

ISO

kojic acid results in increased expression of PRRC2C mRNA

NCBI chr13:77,537,226...77,606,926
Ensembl chr13:77,537,814...77,607,001

G

paired related homeobox 1

decreases expression

ISO

kojic acid results in decreased expression of PRRX1 mRNA

NCBI chr13:78,136,783...78,205,379
Ensembl chr13:78,136,783...78,204,058

G

proteasome 26S subunit, ATPase 6

decreases expression

ISO

kojic acid results in decreased expression of PSMC6 mRNA

NCBI chr15:21,022,314...21,043,785
Ensembl chr15:21,022,314...21,043,785

G

proteasome 26S subunit, non-ATPase 3

decreases expression

ISO

kojic acid results in decreased expression of PSMD3 mRNA

NCBI chr10:84,139,249...84,151,879
Ensembl chr10:84,139,677...84,151,878

G

pseudouridine synthase 7 like

decreases expression

ISO

kojic acid results in decreased expression of PUS7L mRNA

NCBI chr 7:127,538,785...127,561,936
Ensembl chr 7:127,538,558...127,561,798

G

RAB3 GTPase activating protein catalytic subunit 1

increases expression

ISO

kojic acid results in increased expression of RAB3GAP1 mRNA

NCBI chr13:41,908,179...41,981,611
Ensembl chr13:41,908,051...41,981,611

G

RAB6B, member RAS oncogene family

decreases expression

ISO

kojic acid results in decreased expression of RAB6B mRNA

NCBI chr 8:112,574,223...112,642,911
Ensembl chr 8:112,574,167...112,642,907

G

RAD1 checkpoint DNA exonuclease

increases expression

ISO

kojic acid results in increased expression of RAD1 mRNA

NCBI chr 2:61,188,755...61,196,868
Ensembl chr 2:61,188,727...61,196,867

G

RAD23 homolog A, nucleotide excision repair protein

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RAD23A mRNA

NCBI chr19:40,219,235...40,225,543
Ensembl chr19:40,219,636...40,225,543

G

RAD50 double strand break repair protein

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of RAD50 mRNA

NCBI chr10:38,310,147...38,362,100
Ensembl chr10:38,310,147...38,362,100

G

retinoic acid receptor, alpha

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RARA mRNA

NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160

G

retinoic acid receptor, beta

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of RARB mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of RARB mRNA

NCBI chr15:10,837,252...11,482,037
Ensembl chr15:11,131,358...11,482,040

G

ras related dexamethasone induced 1

increases expression

ISO

kojic acid results in increased expression of RASD1 mRNA

NCBI chr10:45,265,975...45,275,279
Ensembl chr10:45,265,979...45,267,710

G

RasGEF domain family, member 1B

decreases expression

ISO

kojic acid results in decreased expression of RASGEF1B mRNA

NCBI chr14:10,164,366...10,684,184
Ensembl chr14:10,644,521...10,697,296

G

Ras association domain family member 3

increases expression

ISO

kojic acid results in increased expression of RASSF3 mRNA

NCBI chr 7:58,821,360...58,886,020
Ensembl chr 7:58,821,360...58,886,020

G

RB1-inducible coiled-coil 1

decreases expression

ISO

kojic acid results in decreased expression of RB1CC1 mRNA

NCBI chr 5:17,948,522...18,012,434
Ensembl chr 5:17,948,522...18,012,434

G

RNA binding motif protein 38

decreases expression

ISO

kojic acid results in decreased expression of RBM38 mRNA

NCBI chr 3:182,219,898...182,232,723
Ensembl chr 3:182,219,899...182,232,714

G

RecQ like helicase

decreases expression

ISO

kojic acid results in decreased expression of RECQL mRNA

NCBI chr 4:177,039,351...177,063,968
Ensembl chr 4:177,035,128...177,063,838

G

regulating synaptic membrane exocytosis 2

decreases expression

ISO

kojic acid results in decreased expression of RIMS2 mRNA

NCBI chr 7:72,133,004...72,644,059
Ensembl chr 7:72,133,170...72,645,499

G

round spermatid basic protein 1

decreases expression

ISO

kojic acid results in decreased expression of RSBN1 mRNA

NCBI chr 2:194,105,058...194,159,142
Ensembl chr 2:194,105,061...194,159,142

G

serum amyloid A4

decreases expression

ISO

kojic acid results in decreased expression of SAA4 mRNA

NCBI chr 1:106,383,856...106,388,158
Ensembl chr 1:106,383,856...106,387,354

G

scavenger receptor class B, member 1

increases expression

ISO

kojic acid results in increased expression of SCARB1 mRNA

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

sodium voltage-gated channel alpha subunit 10

decreases expression

ISO

kojic acid results in decreased expression of SCN10A mRNA

NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:128,228,424...128,340,298

G

sterol carrier protein 2

decreases expression

ISO

kojic acid results in decreased expression of SCP2 mRNA

NCBI chr 5:128,035,714...128,110,015
Ensembl chr 5:128,008,125...128,110,043

G

syndecan 4

decreases expression

ISO

kojic acid results in decreased expression of SDC4 mRNA

NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:173,574,239...173,593,670

G

SEC24 homolog B, COPII coat complex component

increases expression

ISO

kojic acid results in increased expression of SEC24B mRNA

NCBI chr 2:221,236,897...221,306,986
Ensembl chr 2:221,236,898...221,306,919

G

SEC62 homolog, preprotein translocation factor

decreases expression

ISO

kojic acid results in decreased expression of SEC62 mRNA

NCBI chr 2:114,499,317...114,526,705
Ensembl chr 2:114,499,317...114,530,321

G

secreted and transmembrane 1B

decreases expression

ISO

kojic acid results in decreased expression of SECTM1 mRNA

NCBI chr10:106,822,397...106,832,105
Ensembl chr10:106,822,397...106,832,104

G

septin 7

decreases expression

ISO

kojic acid results in decreased expression of SEPTIN7 mRNA

NCBI chr 8:31,995,597...32,059,069
Ensembl chr 8:31,995,005...32,059,072

G

serpin family A member 5

decreases expression

ISO

kojic acid results in decreased expression of SERPINA5 mRNA

NCBI chr 6:128,774,006...128,793,187
Ensembl chr 6:128,784,991...128,793,186

G

SHC binding and spindle associated 1

increases expression

ISO

kojic acid results in increased expression of SHCBP1 mRNA

NCBI chr16:91,373,843...91,405,409
Ensembl chr16:91,373,871...91,405,409

G

SIN3 transcription regulator family member B

decreases expression

ISO

kojic acid results in decreased expression of SIN3B mRNA

NCBI chr16:17,157,352...17,194,051
Ensembl chr16:17,157,352...17,270,664

G

solute carrier family 17, member 2

decreases expression

ISO

kojic acid results in decreased expression of SLC17A2 mRNA

NCBI chr17:41,748,195...41,767,601
Ensembl chr17:41,748,195...41,764,180

G

solute carrier family 25 member 2

decreases expression

ISO

kojic acid results in decreased expression of SLC25A2 mRNA

NCBI chr18:29,704,182...29,707,563
Ensembl chr18:29,703,871...29,708,827

G

solute carrier family 38, member 4

decreases expression

ISO

kojic acid results in decreased expression of SLC38A4 mRNA

NCBI chr 7:130,022,039...130,082,169
Ensembl chr 7:130,023,980...130,082,097

G

structural maintenance of chromosomes 6

decreases expression

ISO

kojic acid results in decreased expression of SMC6 mRNA

NCBI chr 6:39,697,810...39,752,275
Ensembl chr 6:39,697,811...39,752,279

G

small integral membrane protein 8

decreases expression

ISO

kojic acid results in decreased expression of SMIM8 mRNA

NCBI chr 5:54,132,905...54,141,940
Ensembl chr 5:54,132,905...54,141,729

G

sorting nexin 10

decreases expression

ISO

kojic acid results in decreased expression of SNX10 mRNA

NCBI chr 4:81,943,262...82,007,667
Ensembl chr 4:81,943,287...82,007,651

G

sterol O-acyltransferase 2

increases expression

ISO

kojic acid results in increased expression of SOAT2 mRNA

NCBI chr 7:135,160,424...135,173,521
Ensembl chr 7:135,160,402...135,173,513

G

superoxide dismutase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

spermatogenesis associated 25

decreases expression

ISO

kojic acid results in decreased expression of SPATA25 mRNA

NCBI chr 3:173,981,863...173,983,818
Ensembl chr 3:173,981,866...173,983,818

G

secreted phosphoprotein 1

increases expression

ISO

kojic acid results in increased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

serine palmitoyltransferase, long chain base subunit 1

increases expression

ISO

kojic acid results in increased expression of SPTLC1 mRNA

NCBI chr17:12,029,189...12,068,234
Ensembl chr17:12,029,189...12,068,234

G

serine and arginine rich splicing factor 2

increases expression

ISO

kojic acid results in increased expression of SRSF2 mRNA

NCBI chr10:102,550,962...102,554,200
Ensembl chr10:102,553,072...102,554,141

G

SSX family member 1

increases expression

ISO

kojic acid results in increased expression of SSX1 mRNA

NCBI chr X:16,603,888...16,612,203
Ensembl chr X:16,604,449...16,612,210

G

ST13, Hsp70 interacting protein

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of ST13 mRNA

NCBI chr 7:114,769,758...114,805,877
Ensembl chr 7:114,769,759...114,805,941

G

ST18 C2H2C-type zinc finger transcription factor

decreases expression

ISO

kojic acid results in decreased expression of ST18 mRNA

NCBI chr 5:17,369,383...17,701,094
Ensembl chr 5:17,371,000...17,458,676

G

StAR-related lipid transfer domain containing 8

decreases expression

ISO

kojic acid results in decreased expression of STARD8 mRNA

NCBI chr X:68,119,276...68,236,247
Ensembl chr X:68,119,644...68,236,246

G

syntaxin 6

increases expression

ISO

kojic acid results in increased expression of STX6 mRNA

NCBI chr13:69,882,647...69,928,895
Ensembl chr13:69,882,620...69,931,036

G

sulfotransferase family 1A member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1A1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of SULT1A1 mRNA

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

sulfotransferase family 1B member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1B1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of SULT1B1 mRNA

NCBI chr14:20,771,917...20,784,665
Ensembl chr14:20,771,868...20,785,549

G

sulfotransferase family 1C member 2A

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1C2 mRNA

NCBI chr 9:7,075,873...7,103,316
Ensembl chr 9:7,066,905...7,244,132

G

sulfotransferase family 1C member 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1C1 mRNA

NCBI chr 9:7,548,839...7,594,299
Ensembl chr 9:7,548,622...7,594,295

G

sulfotransferase family 1E member 1

multiple interactions

EXP
ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA
[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of SULT1E1 mRNA

PMID:17917374 PMID:18544905

NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716

G

sulfotransferase family 4A, member 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of SULT4A1 mRNA

NCBI chr 7:117,096,064...117,120,714
Ensembl chr 7:117,096,064...117,120,083

G

SUZ12 polycomb repressive complex 2 subunit

decreases expression

ISO

kojic acid results in decreased expression of SUZ12 mRNA

NCBI chr10:65,464,948...65,510,846
Ensembl chr10:65,464,969...65,510,846

G

switching B-cell complex subunit SWAP70

increases expression

ISO

kojic acid results in increased expression of SWAP70 mRNA

NCBI chr 1:173,702,338...173,763,540
Ensembl chr 1:173,702,347...173,763,947

G

SYF2 pre-mRNA-splicing factor

decreases expression

ISO

kojic acid results in decreased expression of SYF2 mRNA

NCBI chr 5:152,440,171...152,448,094
Ensembl chr 5:152,440,054...152,448,092

G

symplekin scaffold protein

decreases expression

ISO

kojic acid results in decreased expression of SYMPK mRNA

NCBI chr 1:87,800,416...87,828,727
Ensembl chr 1:87,799,853...87,828,727

G

synaptotagmin binding, cytoplasmic RNA interacting protein

increases expression

ISO

kojic acid results in increased expression of SYNCRIP mRNA

NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:98,282,358...98,315,386

G

TATA-box binding protein associated factor 15

decreases expression

ISO

kojic acid results in decreased expression of TAF15 mRNA

NCBI chr10:68,770,408...68,802,458
Ensembl chr10:68,770,430...68,802,458

G

TAL bHLH transcription factor 1, erythroid differentiation factor

decreases expression

ISO

kojic acid results in decreased expression of TAL1 mRNA

NCBI chr 5:133,823,093...133,837,737
Ensembl chr 5:133,826,003...133,837,738

G

thromboxane A synthase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TBXAS1 mRNA

NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:68,631,838...68,803,969

G

transcription factor 21

decreases expression

ISO

kojic acid results in decreased expression of TCF21 mRNA

NCBI chr 1:24,520,499...24,523,358
Ensembl chr 1:24,520,481...24,523,348

G

terminal nucleotidyltransferase 4B

decreases expression

ISO

kojic acid results in decreased expression of TENT4B mRNA

NCBI chr19:34,984,244...35,042,423
Ensembl chr19:34,980,296...35,042,399

G

transforming growth factor, beta 1

multiple interactions

EXP

[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

thyroid hormone receptor beta

decreases expression

ISO

kojic acid results in decreased expression of THRB mRNA

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

decreases expression

ISO

kojic acid results in decreased expression of TIE mRNA

NCBI chr 5:137,285,408...137,305,047
Ensembl chr 5:137,285,408...137,304,981

G

TIR domain containing adaptor protein

decreases expression

ISO

kojic acid results in decreased expression of TIRAP mRNA

NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:41,791,878...41,796,312

G

transmembrane and coiled-coil domains 5A

increases expression

ISO

kojic acid results in increased expression of TMCO5 mRNA

NCBI chr 3:124,187,005...124,200,308
Ensembl chr 3:124,187,067...124,200,308

G

transmembrane protein 217

increases expression

ISO

kojic acid results in increased expression of TMEM217 mRNA

NCBI chr20:7,594,223...7,620,628
Ensembl chr20:7,594,405...7,620,558

G

transmembrane protein 59-like

decreases expression

ISO

kojic acid results in decreased expression of TMEM59L mRNA

NCBI chr16:18,975,217...18,979,354
Ensembl chr16:18,974,709...18,981,586

G

thioredoxin-related transmembrane protein 1

decreases expression

ISO

kojic acid results in decreased expression of TMX1 mRNA

NCBI chr 6:94,696,699...94,707,751
Ensembl chr 6:94,696,358...94,708,618

G

tumor necrosis factor

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TNF mRNA

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 8 like 1

decreases expression

ISO

kojic acid results in decreased expression of TNFAIP8L1 mRNA

NCBI chr 9:1,075,724...1,088,256
Ensembl chr 9:1,055,801...1,092,803

G

TNF superfamily member 10

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TNFSF10 mRNA

NCBI chr 2:112,136,550...112,155,903

G

torsin family 4, member A

decreases expression

ISO

kojic acid results in decreased expression of TOR4A mRNA

NCBI chr 3:28,402,454...28,406,141
Ensembl chr 3:28,399,513...28,406,473

G

tumor protein p53

multiple interactions

EXP
ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TP53 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of TRP53 mRNA

PMID:17917374 PMID:18544905

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 binding protein, 2

increases expression

ISO

kojic acid results in increased expression of TP53BP2 mRNA

NCBI chr13:96,620,429...96,677,090
Ensembl chr13:96,620,428...96,677,616

G

two pore segment channel 1

increases expression

ISO

kojic acid results in increased expression of TPCN1 mRNA

NCBI chr12:41,633,399...41,690,200
Ensembl chr12:41,633,398...41,690,200

G

tyrosylprotein sulfotransferase 2

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TPST2 mRNA

NCBI chr12:49,982,281...50,024,489
Ensembl chr12:49,982,281...50,023,058

G

TNFRSF1A-associated via death domain

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TRADD mRNA; [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of TRADD mRNA

NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550

G

translocation associated membrane protein 1

decreases expression

ISO

kojic acid results in decreased expression of TRAM1 mRNA

NCBI chr 5:10,425,710...10,450,669
Ensembl chr 5:10,425,633...10,470,056

G

translocation associated membrane protein 2

decreases expression

ISO

kojic acid results in decreased expression of TRAM2 mRNA

NCBI chr 9:30,915,624...30,995,162
Ensembl chr 9:30,915,624...30,995,162

G

triggering receptor expressed on myeloid cells 1

decreases expression

ISO

kojic acid results in decreased expression of TREM1 mRNA

NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:20,261,408...20,276,892

G

tRNA methyltransferase 10C, mitochondrial RNase P subunit

decreases expression

ISO

kojic acid results in decreased expression of TRMT10C mRNA

NCBI chr11:58,053,455...58,058,533
Ensembl chr11:58,033,201...58,059,062

G

tetraspanin 8

increases expression

ISO

kojic acid results in increased expression of TSPAN8 mRNA

NCBI chr 7:53,331,019...53,365,402
Ensembl chr 7:53,330,963...53,365,401

G

tetratricopeptide repeat domain 9

increases expression

ISO

kojic acid results in increased expression of TTC9 mRNA

NCBI chr 6:107,064,527...107,099,361
Ensembl chr 6:107,064,527...107,099,361

G

Ttk protein kinase

decreases expression

ISO

kojic acid results in decreased expression of TTK mRNA

NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:93,634,319...93,672,664

G

TUB like protein 3

decreases expression

ISO

kojic acid results in decreased expression of TULP3 mRNA

NCBI chr 4:163,276,583...163,318,297
Ensembl chr 4:163,276,583...163,318,390

G

twinfilin actin-binding protein 1

decreases expression

ISO

kojic acid results in decreased expression of TWF1 mRNA

NCBI chr 7:127,595,210...127,607,821
Ensembl chr 7:127,595,210...127,607,105

G

tyrosinase

decreases activity
increases expression

ISO

kojic acid results in decreased activity of TYR protein
kojic acid results in increased expression of TYR mRNA; kojic acid results in increased expression of TYR protein

PMID:23738040 PMID:27586645

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

tyrosinase-related protein 1

decreases expression

ISO

kojic acid results in decreased expression of TYRP1 protein

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:100,327,125...100,345,657

G

ubiquitin-conjugating enzyme E2D 2B

decreases expression

ISO

kojic acid results in decreased expression of UBE2D4 mRNA

NCBI chr14:2,060,926...2,062,400
Ensembl chr14:2,048,235...2,063,764

G

ubiquitin-conjugating enzyme E2E 1

decreases expression

ISO

kojic acid results in decreased expression of UBE2E1 mRNA

NCBI chr15:9,870,528...9,924,194
Ensembl chr15:9,862,219...9,924,194

G

ubiquitin-conjugating enzyme E2M

decreases expression

ISO

kojic acid results in decreased expression of UBE2M mRNA

NCBI chr 1:82,734,761...82,738,298
Ensembl chr 1:82,732,231...82,738,613

G

ubiquitin protein ligase E3 component n-recognin 7

increases expression

ISO

kojic acid results in increased expression of UBR7 mRNA

NCBI chr 6:127,663,454...127,683,302
Ensembl chr 6:127,663,447...127,694,390

G

ubiquitin recognition factor in ER associated degradation 1

increases expression

ISO

kojic acid results in increased expression of UFD1 mRNA

NCBI chr11:95,665,971...95,689,423
Ensembl chr11:95,665,972...95,689,434

G

UDP glucuronosyltransferase 1 family, polypeptide A2

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of UGT1A2 mRNA

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A6a

multiple interactions

EXP

[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of UGT1A6 mRNA

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

unc-5 netrin receptor C

decreases expression

ISO

kojic acid results in decreased expression of UNC5C mRNA

NCBI chr 2:232,854,352...233,208,482
Ensembl chr 2:232,846,262...233,208,482

G

uracil-DNA glycosylase

multiple interactions

ISO

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of UNG mRNA

NCBI chr12:48,145,838...48,154,789
Ensembl chr12:48,145,838...48,155,257

G

ubiquitin specific peptidase 1

decreases expression

ISO

kojic acid results in decreased expression of USP1 mRNA

NCBI chr 5:118,703,056...118,714,426
Ensembl chr 5:118,702,868...118,714,434

G

ubiquitin specific peptidase 44

decreases expression

ISO

kojic acid results in decreased expression of USP44 mRNA

NCBI chr 7:30,251,142...30,301,185
Ensembl chr 7:30,251,205...30,297,906

G

UTP11, small subunit processome component

increases expression

ISO

kojic acid results in increased expression of UTP11 mRNA

NCBI chr 5:142,215,974...142,230,859
Ensembl chr 5:142,215,975...142,230,859

G

Wnt family member 10A

decreases expression

ISO

kojic acid results in decreased expression of WNT10A mRNA

NCBI chr 9:83,798,594...83,811,060
Ensembl chr 9:83,798,594...83,811,067

G

YEATS domain containing 2

increases expression

ISO

kojic acid results in increased expression of YEATS2 mRNA

NCBI chr11:94,247,538...94,333,652
Ensembl chr11:94,247,538...94,333,292

G

zinc finger CCCH-type containing 15

decreases expression

ISO

kojic acid results in decreased expression of ZC3H15 mRNA

NCBI chr 3:89,151,432...89,171,203
Ensembl chr 3:89,151,509...89,171,202

G

zinc finger DHHC-type palmitoyltransferase 20

decreases expression

ISO

kojic acid results in decreased expression of ZDHHC20 mRNA

NCBI chr15:36,095,624...36,154,546
Ensembl chr15:36,098,282...36,154,532

G

zinc finger AN1-type containing 1

decreases expression

ISO

kojic acid results in decreased expression of ZFAND1 mRNA

NCBI chr 2:93,351,918...93,364,959
Ensembl chr 2:93,351,917...93,360,665

G

zinc finger protein 146

decreases expression

ISO

kojic acid results in decreased expression of ZNF146 mRNA

NCBI chr 1:94,537,054...94,549,315
Ensembl chr 1:94,536,083...94,551,860

G

zinc finger protein 414

decreases expression

ISO

kojic acid results in decreased expression of ZNF414 mRNA

NCBI chr 7:15,122,408...15,125,115
Ensembl chr 7:15,122,401...15,125,755

G

zinc finger protein 438

increases expression

ISO

kojic acid results in increased expression of ZNF438 mRNA

NCBI chr17:57,121,637...57,242,892
Ensembl chr17:57,121,302...57,245,607

G

zinc finger protein 483

decreases expression

ISO

kojic acid results in decreased expression of ZNF483 mRNA

NCBI chr 5:78,558,213...78,575,559
Ensembl chr 5:78,558,304...78,575,552

G

zinc finger with KRAB and SCAN domains 8

decreases expression

ISO

kojic acid results in decreased expression of ZKSCAN8 mRNA

NCBI chr17:47,735,120...47,753,126
Ensembl chr17:47,735,120...47,753,126

G

zinc finger, MYND-type containing 15

decreases expression

ISO

kojic acid results in decreased expression of ZMYND15 mRNA

NCBI chr10:55,669,832...55,676,446
Ensembl chr10:55,669,752...55,676,434

G

zona pellucida glycoprotein 2

decreases expression

ISO

kojic acid results in decreased expression of ZP2 mRNA

NCBI chr 1:183,944,840...183,956,619
Ensembl chr 1:183,939,880...183,963,075

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor nuclear translocator

increases activity

EXP

Mimosine results in increased activity of ARNT protein

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

activating transcription factor 1

increases activity

EXP

Mimosine results in increased activity of ATF1 protein

NCBI chr 7:133,240,774...133,283,488
Ensembl chr 7:133,241,197...133,283,485

G

BCL2, apoptosis regulator

affects expression

ISO

Mimosine affects the expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions

ISO

Mimosine results in increased cleavage of and results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

ISO

Mimosine results in increased cleavage of and results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

ISO

CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin D1

decreases expression

ISO

Mimosine results in decreased expression of CCND1

PMID:10530763 PMID:10995875

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

Mimosine results in increased expression of CDKN1A

PMID:10530763 PMID:10995875

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

Mimosine results in increased expression of CDKN1B

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cAMP responsive element binding protein 1

increases activity

EXP

Mimosine results in increased activity of CREB1 protein

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

endothelin converting enzyme 1

increases expression

EXP
ISO

Mimosine results in increased expression of ECE1 mRNA; Mimosine results in increased expression of ECE1 protein

NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:155,360,639...155,462,719

G

endothelin 1

increases expression

ISO
EXP

Mimosine results in increased expression of EDN1 mRNA; Mimosine results in increased expression of EDN1 protein

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

hypoxia inducible factor 1 subunit alpha

increases activity
increases expression

EXP
ISO

Mimosine results in increased activity of HIF1A protein
Mimosine results in increased expression of HIF1A protein

PMID:10559391 PMID:24349381 PMID:25469848

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

luteinizing hormone/choriogonadotropin receptor

decreases expression

EXP
ISO

Mimosine results in decreased expression of LHCGR mRNA

NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:11,415,415...11,478,061

G

neuromedin B receptor

increases expression

ISO

Mimosine results in increased expression of NMBR protein

NCBI chr 1:10,942,476...10,966,174
Ensembl chr 1:10,954,916...10,965,555

G

solute carrier family 2 member 1

increases expression

ISO
EXP

Mimosine results in increased expression of SLC2A1 mRNA

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

signal transducer and activator of transcription 3

increases phosphorylation

EXP

Mimosine results in increased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

tumor necrosis factor

multiple interactions
decreases activity

ISO
EXP

Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; ferrous sulfate inhibits the reaction [Mimosine results in decreased activity of TNF protein]
Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 1A

multiple interactions
increases cleavage

ISO

Acetylcysteine inhibits the reaction [Mimosine results in increased cleavage of TNFRSF1A protein]

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

N-phenylthiourea

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonic anhydrase 1

decreases activity

ISO

Phenylthiourea analog results in decreased activity of CA1 protein

NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454

G

carbonic anhydrase 2

decreases activity

ISO

Phenylthiourea analog results in decreased activity of CA2 protein

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

caspase 9

increases expression

ISO

Phenylthiourea results in increased expression of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

flavin containing dimethylaniline monoxygenase 3

increases response to substance

ISO

FMO3 protein results in increased susceptibility to Phenylthiourea

NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

ISO

Phenylthiourea results in decreased expression of FOS protein

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

mitogen activated protein kinase 1

increases phosphorylation

ISO

Phenylthiourea results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation

ISO

Phenylthiourea results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

melanocyte inducing transcription factor

increases expression

ISO

Phenylthiourea results in increased expression of MITF protein

NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:131,965,714...132,177,790

G

peroxisome proliferator activated receptor alpha

increases expression

ISO

Phenylthiourea results in increased expression of PPARA protein

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

RELA proto-oncogene, NF-kB subunit

increases expression

ISO

Phenylthiourea results in increased expression of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

taste receptor, type 2, member 138

affects response to substance
affects activity
increases activity
multiple interactions

ISO

TAS2R38 gene polymorphism affects the susceptibility to Phenylthiourea
Phenylthiourea affects the activity of TAS2R38
Phenylthiourea results in increased activity of TAS2R38 protein
4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]

PMID:17684414 PMID:21629661 PMID:22384968

NCBI chr 4:70,395,042...70,396,037

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

quercitrin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 4

decreases expression

ISO

quercitrin results in decreased expression of ABCC4 mRNA

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily F member 2

increases expression

ISO

quercitrin results in increased expression of ABCF2 mRNA

NCBI chr 4:11,485,865...11,500,067
Ensembl chr 4:11,487,395...11,500,053

G

acyl-CoA binding domain containing 6

decreases expression

ISO

quercitrin results in decreased expression of ACBD6 mRNA

NCBI chr13:70,277,036...70,412,598
Ensembl chr13:70,277,057...70,412,597

G

acyl-CoA binding domain containing 7

increases expression

ISO

quercitrin results in increased expression of ACBD7 mRNA

NCBI chr17:79,813,106...79,821,254
Ensembl chr17:79,813,106...79,818,448

G

actinin, alpha 1

affects expression

ISO

quercitrin affects the expression of ACTN1 mRNA

NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:104,731,485...104,826,172

G

actinin alpha 4

affects expression

ISO

quercitrin affects the expression of ACTN4 mRNA

NCBI chr 1:93,310,294...93,379,369
Ensembl chr 1:93,310,278...93,379,320

G

adhesion G protein-coupled receptor B1

decreases expression

ISO

quercitrin results in decreased expression of ADGRB1 mRNA

NCBI chr 7:108,293,681...108,365,892
Ensembl chr 7:108,293,818...108,365,870

G

adhesion G protein-coupled receptor F1

decreases expression

ISO

quercitrin results in decreased expression of ADGRF1 mRNA

NCBI chr 9:25,158,198...25,210,744
Ensembl chr 9:25,147,588...25,208,916

G

adhesion G protein-coupled receptor G1

decreases expression

ISO

quercitrin results in decreased expression of ADGRG1 mRNA

NCBI chr19:10,009,983...10,047,138
Ensembl chr19:10,010,031...10,047,124

G

adhesion G protein-coupled receptor G6

decreases expression

ISO

quercitrin results in decreased expression of ADGRG6 mRNA

NCBI chr 1:10,633,004...10,774,685
Ensembl chr 1:10,631,829...10,774,023

G

adhesion G protein-coupled receptor G7

increases expression

ISO

quercitrin results in increased expression of ADGRG7 mRNA

NCBI chr11:57,282,904...57,345,417
Ensembl chr11:57,282,904...57,345,417

G

adhesion G protein-coupled receptor V1

increases expression

ISO

quercitrin results in increased expression of ADGRV1 mRNA

NCBI chr 2:13,067,149...13,647,407
Ensembl chr 2:13,067,150...13,647,372

G

adenosine kinase

decreases expression

ISO

quercitrin results in decreased expression of ADK mRNA

NCBI chr15:2,912,543...3,295,745
Ensembl chr15:2,912,544...3,295,745

G

adrenoceptor alpha 2C

increases expression

ISO

quercitrin results in increased expression of ADRA2C mRNA

NCBI chr14:79,695,514...79,697,476
Ensembl chr14:79,694,995...79,706,656

G

AHNAK nucleoprotein 2

increases expression

ISO

quercitrin results in increased expression of AHNAK2 mRNA

NCBI chr 6:137,648,867...137,697,580
Ensembl chr 6:137,652,537...137,675,546

G

alkB homolog 7

increases expression

ISO

quercitrin results in increased expression of ALKBH7 mRNA

NCBI chr 9:1,925,896...1,928,048
Ensembl chr 9:1,925,743...1,928,048

G

anaphase promoting complex subunit 15

decreases expression

ISO

quercitrin results in decreased expression of ANAPC15 mRNA

NCBI chr 1:165,650,478...165,678,004
Ensembl chr 1:165,675,754...165,679,501

G

androgen receptor

increases expression

ISO

quercitrin results in increased expression of AR mRNA

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

increases expression

ISO

quercitrin results in increased expression of ARAP2 mRNA

NCBI chr14:50,921,323...51,120,972
Ensembl chr14:50,921,713...51,120,962

G

ankyrin repeat and SOCS box-containing 6

increases expression

ISO

quercitrin results in increased expression of ASB6 mRNA

NCBI chr 3:34,508,390...34,513,033
Ensembl chr 3:34,508,140...34,513,033

G

autophagy related 7

decreases expression

ISO

quercitrin results in decreased expression of ATG7 mRNA

NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319

G

BAR/IMD domain containing adaptor protein 2

affects expression

ISO

quercitrin affects the expression of BAIAP2 mRNA

NCBI chr10:105,721,371...105,788,549
Ensembl chr10:105,721,417...105,788,549

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

bradykinin receptor B1

decreases expression

ISO

quercitrin results in decreased expression of BDKRB1 mRNA

NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:130,275,478...130,280,973

G

similar to human chromosome 2 open reading frame 49

decreases expression

ISO

quercitrin results in decreased expression of C2ORF49 mRNA

NCBI chr 9:52,863,565...52,874,234
Ensembl chr 9:52,863,542...52,874,234

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

ISO

quercitrin results in decreased expression of CAMK2B mRNA

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

caspase 3

increases activity
multiple interactions

ISO
EXP

quercitrin results in increased activity of CASP3 protein
quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]

PMID:23138875 PMID:25193878

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases expression

ISO

quercitrin results in increased expression of CASP8 mRNA

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

C-C motif chemokine receptor 9

decreases expression

ISO

quercitrin results in decreased expression of CCR9 mRNA

NCBI chr 8:132,273,581...132,287,651
Ensembl chr 8:132,273,544...132,287,883

G

C-C motif chemokine receptor like 2

increases expression

ISO

quercitrin results in increased expression of CCRL2 mRNA

NCBI chr 8:119,912,671...119,915,313
Ensembl chr 8:119,911,288...119,922,380

G

CD302 molecule

decreases expression

ISO

quercitrin results in decreased expression of CD302 mRNA

NCBI chr 3:65,131,017...65,164,737
Ensembl chr 3:65,113,102...65,164,737

G

CD38 molecule

decreases expression

ISO

quercitrin results in decreased expression of CD38 mRNA

NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505

G

CD74 molecule

affects expression

ISO

quercitrin affects the expression of CD74 mRNA

NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410

G

cadherin 1

decreases expression

ISO

quercitrin results in decreased expression of CDH1 mRNA

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cyclin-dependent kinase inhibitor 3

decreases expression

ISO

quercitrin results in decreased expression of CDKN3 mRNA

NCBI chr15:22,502,299...22,513,725
Ensembl chr15:22,502,382...22,513,722

G

cadherin, EGF LAG seven-pass G-type receptor 3

increases expression

ISO

quercitrin results in increased expression of CELSR3 mRNA

NCBI chr 8:118,409,136...118,438,593
Ensembl chr 8:118,409,136...118,436,847

G

centrosomal protein 95

increases expression

ISO

quercitrin results in increased expression of CEP95 mRNA

NCBI chr10:92,231,829...92,259,813
Ensembl chr10:92,231,512...92,259,810

G

ceramide synthase 5

increases expression

ISO

quercitrin results in increased expression of CERS5 mRNA

NCBI chr 7:132,738,834...132,776,920
Ensembl chr 7:132,738,834...132,776,786

G

cilia and flagella associated protein 298

decreases expression

ISO

quercitrin results in decreased expression of CFAP298 mRNA

NCBI chr11:43,667,996...43,678,049
Ensembl chr11:43,668,014...43,677,382

G

chromodomain helicase DNA binding protein 2

decreases expression

ISO

quercitrin results in decreased expression of CHD2 mRNA

NCBI chr 1:136,597,993...136,726,874
Ensembl chr 1:136,599,900...136,710,335

G

claudin 10

affects expression

ISO

quercitrin affects the expression of CLDN10 mRNA

NCBI chr15:102,269,858...102,361,589
Ensembl chr15:102,269,858...102,361,589

G

claudin 23

affects expression

ISO

quercitrin affects the expression of CLDN23 mRNA

NCBI chr16:63,117,045...63,118,769
Ensembl chr16:63,116,781...63,118,957

G

claudin 4

affects expression

ISO

quercitrin affects the expression of CLDN4 mRNA

NCBI chr12:27,388,160...27,389,958
Ensembl chr12:27,387,981...27,389,958

G

claudin 8

affects expression

ISO

quercitrin affects the expression of CLDN8 mRNA

NCBI chr11:41,362,081...41,364,330

G

collagen type III alpha 1 chain

decreases expression

ISO

quercitrin results in decreased expression of COL3A1 mRNA

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

coenzyme Q3 methyltransferase

decreases expression

ISO

quercitrin results in decreased expression of COQ3 mRNA

NCBI chr 5:40,226,313...40,257,383
Ensembl chr 5:40,226,368...40,257,617

G

cysteine-rich secretory protein 1

decreases expression

ISO

quercitrin results in decreased expression of CRISP1 mRNA

NCBI chr 9:28,238,326...28,265,344
Ensembl chr 9:28,238,328...28,265,344

G

crystallin zeta like 1

decreases expression

ISO

quercitrin results in decreased expression of CRYZL1 mRNA

NCBI chr11:44,419,099...44,464,366
Ensembl chr11:44,419,103...44,463,793

G

casein kinase 2 alpha 1

affects expression

ISO

quercitrin affects the expression of CSNK2A1 mRNA

NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698

G

casein kinase 2 alpha 2

affects expression

ISO

quercitrin affects the expression of CSNK2A2 mRNA

NCBI chr19:9,562,340...9,602,136
Ensembl chr19:9,562,321...9,602,136

G

CTD small phosphatase like 2

decreases expression

ISO

quercitrin results in decreased expression of CTDSPL2 mRNA

NCBI chr 3:129,365,709...129,424,232
Ensembl chr 3:129,368,938...129,424,232

G

cathepsin B

affects expression

ISO

quercitrin affects the expression of CTSB mRNA

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

ISO

quercitrin results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

quercitrin results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 26, subfamily b, polypeptide 1

increases expression

ISO

quercitrin results in increased expression of CYP26B1 mRNA

NCBI chr 4:118,599,356...118,616,176
Ensembl chr 4:118,599,356...118,616,176

G

defective in cullin neddylation 1 domain containing 5

decreases expression

ISO

quercitrin results in decreased expression of DCUN1D5 mRNA

NCBI chr 8:12,697,160...12,718,242
Ensembl chr 8:12,697,127...12,718,991

G

DEAD-box helicase 19B

decreases expression

ISO

quercitrin results in decreased expression of DDX19B mRNA

NCBI chr19:55,877,567...55,910,134
Ensembl chr19:55,877,567...55,906,745

G

DAP3 binding cell death enhancer 1

decreases expression

ISO

quercitrin results in decreased expression of DELE1 mRNA

NCBI chr18:30,325,369...30,349,285
Ensembl chr18:30,336,308...30,349,938

G

diacylglycerol kinase, theta

affects expression

ISO

quercitrin affects the expression of DGKQ mRNA

NCBI chr14:1,203,380...1,217,536
Ensembl chr14:1,203,565...1,218,024

G

dehydrogenase/reductase 11

decreases activity

ISO

quercitrin results in decreased activity of DHRS11 protein

NCBI chr10:70,195,637...70,205,735
Ensembl chr10:70,195,637...70,205,893

G

DTW domain containing 1

decreases expression

ISO

quercitrin results in decreased expression of DTWD1 mRNA

NCBI chr 3:133,845,768...133,859,965
Ensembl chr 3:133,841,935...133,860,316

G

estrogen-induced osteoclastogenesis regulator 1

increases expression

ISO

quercitrin results in increased expression of EEIG1 mRNA

NCBI chr 3:36,220,170...36,252,377
Ensembl chr 3:36,211,730...36,252,378

G

early growth response 2

increases expression

ISO

quercitrin results in increased expression of EGR2 mRNA

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

endothelial PAS domain protein 1

increases expression

ISO

quercitrin results in increased expression of EPAS1 mRNA

NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729

G

ERCC excision repair 1, endonuclease non-catalytic subunit

decreases expression

ISO

quercitrin results in decreased expression of ERCC1 mRNA

NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:88,118,891...88,139,120

G

ERCC excision repair 2, TFIIH core complex helicase subunit

decreases expression

ISO

quercitrin results in decreased expression of ERCC2 mRNA

NCBI chr 1:88,161,342...88,175,102
Ensembl chr 1:88,160,988...88,175,102

G

ERI1 exoribonuclease family member 2

increases expression

ISO

quercitrin results in increased expression of ERI2 mRNA

NCBI chr 1:183,551,919...183,600,134
Ensembl chr 1:183,573,357...183,600,185

G

eva-1 homolog A, regulator of programmed cell death

decreases expression

ISO

quercitrin results in decreased expression of EVA1A mRNA

NCBI chr 4:116,151,595...116,200,827
Ensembl chr 4:116,151,173...116,200,827

G

F11 receptor

affects expression

ISO

quercitrin affects the expression of F11R mRNA

NCBI chr13:86,406,229...86,429,819
Ensembl chr13:86,406,218...86,429,816

G

F2R like trypsin receptor 1

increases expression

ISO

quercitrin results in increased expression of F2RL1 mRNA

NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:28,507,003...28,519,954

G

coagulation factor II (thrombin) receptor-like 2

decreases expression

ISO

quercitrin results in decreased expression of F2RL2 mRNA

NCBI chr 2:28,706,766...28,711,808
Ensembl chr 2:28,706,501...28,712,473

G

coagulation factor III, tissue factor

increases expression

ISO

quercitrin results in increased expression of F3 mRNA

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

fumarylacetoacetate hydrolase domain containing 2A

decreases expression

ISO

quercitrin results in decreased expression of FAHD2A mRNA

NCBI chr 3:135,110,480...135,118,653
Ensembl chr 3:135,109,482...135,118,853

G

Fas apoptotic inhibitory molecule

increases expression

ISO

quercitrin results in increased expression of FAIM mRNA

NCBI chr 8:108,423,259...108,445,365
Ensembl chr 8:108,423,221...108,440,151

G

family with sequence similarity 216, member A

decreases expression

ISO

quercitrin results in decreased expression of FAM216A mRNA

NCBI chr12:39,859,307...39,868,450
Ensembl chr12:39,859,172...39,868,442

G

FAM3 metabolism regulating signaling molecule C

increases expression

ISO

quercitrin results in increased expression of FAM3C mRNA

NCBI chr 4:51,805,686...51,853,030
Ensembl chr 4:51,805,703...51,853,030

G

family with sequence similarity 43, member A

increases expression

ISO

quercitrin results in increased expression of FAM43A mRNA

NCBI chr11:83,633,165...83,636,313
Ensembl chr11:83,633,154...83,695,297

G

family with sequence similarity 50, member A

increases expression

ISO

quercitrin results in increased expression of FAM50A mRNA

NCBI chr X:157,246,533...157,253,650
Ensembl chr X:157,246,533...157,253,650

G

Fas cell surface death receptor

increases expression

ISO

quercitrin results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

follicular dendritic cell secreted protein

decreases expression

ISO

quercitrin results in decreased expression of FDCSP mRNA

NCBI chr14:20,447,761...20,453,227
Ensembl chr14:20,448,935...20,453,227

G

filaggrin

increases expression

ISO

quercitrin results in increased expression of FLG mRNA

NCBI chr 2:181,583,801...181,596,464
Ensembl chr 2:181,583,808...181,595,968

G

frizzled class receptor 4

increases expression

ISO

quercitrin results in increased expression of FZD4 mRNA

NCBI chr 1:152,692,507...152,701,372
Ensembl chr 1:152,692,507...152,701,372

G

gamma-aminobutyric acid type B receptor subunit 2

increases expression

ISO

quercitrin results in increased expression of GABBR2 mRNA

NCBI chr 5:65,743,073...66,083,695
Ensembl chr 5:65,743,073...66,083,695

G

growth arrest and DNA-damage-inducible, alpha

affects expression

ISO

quercitrin affects the expression of GADD45 mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

galactokinase 2

increases expression

ISO

quercitrin results in increased expression of GALK2 mRNA

NCBI chr 3:133,563,524...133,696,423
Ensembl chr 3:133,563,538...133,696,528

G

galanin receptor 3

increases expression

ISO

quercitrin results in increased expression of GALR3 mRNA

NCBI chr 7:112,483,183...112,496,359
Ensembl chr 7:112,485,672...112,488,136

G

GTPase, IMAP family member 6

increases expression

ISO

quercitrin results in increased expression of GIMAP6 mRNA

NCBI chr 4:78,984,597...78,990,006
Ensembl chr 4:78,983,504...78,990,010

G

GLI pathogenesis-related 1

decreases expression

ISO

quercitrin results in decreased expression of GLIPR1 mRNA

NCBI chr 7:49,373,579...49,399,190
Ensembl chr 7:49,373,581...49,384,640

G

golgi integral membrane protein 4

increases expression

ISO

quercitrin results in increased expression of GOLIM4 mRNA

NCBI chr 2:162,939,429...163,031,901
Ensembl chr 2:162,939,429...163,031,901

G

G protein-coupled receptor 137B

increases expression

ISO

quercitrin results in increased expression of GPR137B mRNA

NCBI chr17:92,987,792...93,026,003
Ensembl chr17:92,942,559...93,025,911

G

G-protein coupled receptor 173

increases expression

ISO

quercitrin results in increased expression of GPR173 mRNA

NCBI chr X:24,925,634...24,950,485
Ensembl chr X:24,922,704...24,950,887

G

G protein-coupled receptor 174

increases expression

ISO

quercitrin results in increased expression of GPR174 mRNA

NCBI chr X:76,428,274...76,469,020
Ensembl chr X:76,377,973...76,468,985

G

G protein-coupled receptor 19

increases expression

ISO

quercitrin results in increased expression of GPR19 mRNA

NCBI chr 4:169,442,278...169,468,805
Ensembl chr 4:169,436,658...169,471,249

G

G protein-coupled receptor 4

increases expression

ISO

quercitrin results in increased expression of GPR4 mRNA

NCBI chr 1:87,993,398...88,004,568
Ensembl chr 1:87,993,430...88,006,254

G

G protein-coupled receptor 63

increases expression

ISO

quercitrin results in increased expression of GPR63 mRNA

NCBI chr 5:43,469,112...43,523,840
Ensembl chr 5:43,395,628...43,524,265

G

G protein-coupled receptor 83

increases expression

ISO

quercitrin results in increased expression of GPR83 mRNA

NCBI chr 8:19,974,995...19,985,483
Ensembl chr 8:19,974,993...19,985,490

G

glutathione S-transferase pi 1

decreases expression

ISO

quercitrin results in decreased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

hepatitis A virus cellular receptor 2

increases expression

ISO

quercitrin results in increased expression of HAVCR2 mRNA

NCBI chr10:31,383,801...31,415,334
Ensembl chr10:31,383,925...31,413,872

G

hepatocyte growth factor

increases expression

ISO

quercitrin results in increased expression of HGF mRNA

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

high mobility group AT-hook 2

increases expression

ISO

quercitrin results in increased expression of HMGA2 mRNA

NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:57,765,675...57,880,341

G

high mobility group box 2

decreases expression

ISO

quercitrin results in decreased expression of HMGB2 mRNA

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860

G

hepatocyte nuclear factor 4, alpha

decreases expression

ISO

quercitrin results in decreased expression of HNF4A mRNA

NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758

G

heat shock protein 90 alpha family class A member 1

affects expression

ISO

quercitrin affects the expression of HSP90AA1 mRNA

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein family A (Hsp70) member 1 like

affects expression

ISO

quercitrin affects the expression of HSPA1L mRNA

NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

affects expression

ISO

quercitrin affects the expression of HSPA6 mRNA

NCBI chr13:85,805,911...85,807,052

G

heat shock protein family A (Hsp70) member 8

affects expression

ISO

quercitrin affects the expression of HSPA8 mRNA

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

interferon, alpha 1

affects expression

ISO

quercitrin affects the expression of IFNA1 mRNA

NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809

G

interferon gamma

multiple interactions

EXP

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

insulin-like growth factor 1 receptor

affects expression

ISO

quercitrin affects the expression of IGF1R mRNA

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

interleukin 15

decreases expression

ISO

quercitrin results in decreased expression of IL15 mRNA

NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348

G

interleukin 1 beta

multiple interactions

EXP

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

INO80 complex subunit C

decreases expression

ISO

quercitrin results in decreased expression of INO80C mRNA

NCBI chr18:15,653,508...15,752,455
Ensembl chr18:15,653,511...15,668,144

G

inositol polyphosphate-4-phosphatase type I A

affects expression

ISO

quercitrin affects the expression of INPP4A mRNA

NCBI chr 9:47,024,064...47,142,391
Ensembl chr 9:47,087,471...47,135,968

G

inositol polyphosphate-5-phosphatase D

affects expression

ISO

quercitrin affects the expression of INPP5D mRNA

NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:95,735,530...95,840,589

G

insulin 1

multiple interactions

EXP

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin receptor

affects expression

ISO

quercitrin affects the expression of INSR mRNA

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803

G

interferon regulatory factor 2 binding protein 2

increases expression

ISO

quercitrin results in increased expression of IRF2BP2 mRNA

NCBI chr19:71,456,689...71,462,368
Ensembl chr19:71,456,689...71,462,368

G

integrin subunit beta 1

affects expression

ISO

quercitrin affects the expression of ITGB1 mRNA

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

junction adhesion molecule like

increases expression

ISO

quercitrin results in increased expression of JAML mRNA

NCBI chr 8:54,281,596...54,313,655
Ensembl chr 8:54,281,644...54,313,500

G

Jupiter microtubule associated homolog 2

increases expression

ISO

quercitrin results in increased expression of JPT2 mRNA

NCBI chr10:14,467,652...14,487,769
Ensembl chr10:14,467,661...14,535,664

G

lysine acetyltransferase 5

affects expression

ISO

quercitrin affects the expression of KAT5 mRNA

NCBI chr 1:212,325,089...212,332,640
Ensembl chr 1:212,325,090...212,332,587

G

lysine demethylase 3A

increases expression

ISO

quercitrin results in increased expression of KDM3A mRNA

NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:105,189,208...105,233,370

G

kinase insert domain receptor

increases expression

ISO

quercitrin results in increased expression of KDR mRNA

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

Kelch-like ECH-associated protein 1

increases expression

ISO

quercitrin results in increased expression of KEAP1 mRNA

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

kelch-like family member 28

increases expression

ISO

quercitrin results in increased expression of KLHL28 mRNA

NCBI chr 6:88,723,624...88,755,072
Ensembl chr 6:88,727,205...88,752,457

G

keratin 81

decreases expression

ISO

quercitrin results in decreased expression of KRT81 mRNA

NCBI chr 7:134,455,840...134,460,971
Ensembl chr 7:134,455,842...134,460,967

G

lymphoid enhancer binding factor 1

affects expression

ISO

quercitrin affects the expression of LEF1 mRNA

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929

G

lysophosphatidic acid receptor 3

increases expression

ISO

quercitrin results in increased expression of LPAR3 mRNA

NCBI chr 2:237,785,371...237,854,199
Ensembl chr 2:237,787,766...237,854,197

G

lysophosphatidic acid receptor 5

increases expression

ISO

quercitrin results in increased expression of LPAR5 mRNA

NCBI chr 4:159,556,735...159,570,216
Ensembl chr 4:159,554,805...159,571,894

G

lysophosphatidic acid receptor 6

decreases expression

ISO

quercitrin results in decreased expression of LPAR6 mRNA

NCBI chr15:54,826,110...54,827,919
Ensembl chr15:54,823,717...54,978,783

G

methionine adenosyltransferase 2A

increases expression

ISO

quercitrin results in increased expression of MAT2A mRNA

NCBI chr 4:106,048,043...106,053,612
Ensembl chr 4:106,038,254...106,053,645

G

melanocortin 1 receptor

increases expression

ISO

quercitrin results in increased expression of MC1R mRNA

NCBI chr19:68,360,950...68,363,877
Ensembl chr19:68,360,950...68,363,877

G

MCTS1, re-initiation and release factor

decreases expression

ISO

quercitrin results in decreased expression of MCTS1 mRNA

NCBI chr X:122,215,602...122,228,101
Ensembl chr X:122,216,439...122,229,631

G

mitochondrial ribosomal protein L12

decreases expression

ISO

quercitrin results in decreased expression of MRPL12 mRNA

NCBI chr10:106,256,746...106,261,249
Ensembl chr10:106,256,547...106,263,088

G

mitochondrial ribosomal protein L22

decreases expression

ISO

quercitrin results in decreased expression of MRPL22 mRNA

NCBI chr10:42,843,165...42,856,243
Ensembl chr10:42,843,222...42,856,227

G

moesin

affects expression

ISO

quercitrin affects the expression of MSN mRNA

NCBI chr X:65,005,546...65,073,512
Ensembl chr X:65,005,458...65,075,129

G

myosin light chain 2

affects expression

ISO

quercitrin affects the expression of MYL2 mRNA

NCBI chr12:40,114,964...40,126,236
Ensembl chr12:40,114,958...40,129,149

G

myosin light chain 9

affects expression

ISO

quercitrin affects the expression of MYL9 mRNA

NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:165,742,046...165,748,410

G

myomesin 2

increases expression

ISO

quercitrin results in increased expression of MYOM2 mRNA

NCBI chr16:81,222,467...81,295,025
Ensembl chr16:81,221,938...81,295,162

G

N(alpha)-acetyltransferase 38, NatC auxiliary subunit

decreases expression

ISO

quercitrin results in decreased expression of LSMD1 mRNA

NCBI chr10:54,588,304...54,617,715
Ensembl chr10:54,592,990...54,617,715

G

NFKB inhibitor alpha

multiple interactions

EXP

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nuclear factor related to kappa B binding protein

increases expression

ISO

quercitrin results in increased expression of NFRKB mRNA

NCBI chr 8:38,089,574...38,121,506
Ensembl chr 8:38,089,999...38,121,501

G

neuromedin U receptor 1

decreases expression

ISO

quercitrin results in decreased expression of NMUR1 mRNA

NCBI chr 9:94,480,002...94,486,147
Ensembl chr 9:94,481,248...94,485,428

G

nitric oxide synthase 2

multiple interactions

EXP

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

neuropeptides B and W receptor 1

increases expression

ISO

quercitrin results in increased expression of NPBWR1 mRNA

NCBI chr 5:18,282,180...18,285,622
Ensembl chr 5:18,281,204...18,285,591

G

neuropeptide FF receptor 2

decreases expression

ISO

quercitrin results in decreased expression of NPFFR2 mRNA

NCBI chr14:18,794,868...18,842,186
Ensembl chr14:18,797,234...18,842,186

G

neuropeptide Y receptor Y5

increases expression

ISO

quercitrin results in increased expression of NPY5R mRNA

NCBI chr16:27,822,055...27,830,012
Ensembl chr16:27,816,065...27,830,290

G

NUAK family kinase 2

decreases expression

ISO

quercitrin results in decreased expression of NUAK2 mRNA

NCBI chr13:46,305,744...46,322,755
Ensembl chr13:46,305,975...46,322,748

G

occludin

affects expression

ISO

quercitrin affects the expression of OCLN mRNA

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

ornithine decarboxylase 1

increases expression

ISO

quercitrin results in increased expression of ODC1 mRNA

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146

G

O-GlcNAcase

increases expression

ISO

quercitrin results in increased expression of OGA mRNA

NCBI chr 1:254,547,311...254,589,596
Ensembl chr 1:254,547,311...254,582,855

G

2-oxoglutarate and iron-dependent oxygenase domain containing 2

increases expression

ISO

quercitrin results in increased expression of OGFOD2 mRNA

NCBI chr12:38,143,329...38,146,630
Ensembl chr12:38,142,900...38,146,630

G

OMA1 zinc metallopeptidase

increases expression

ISO

quercitrin results in increased expression of OMA1 mRNA

NCBI chr 5:123,312,038...123,455,540
Ensembl chr 5:123,312,766...123,366,005

G

purinergic receptor P2X 2

increases expression

ISO

quercitrin results in increased expression of P2RX2 mRNA

NCBI chr12:51,999,107...52,002,627
Ensembl chr12:51,999,372...52,002,627

G

purinergic receptor P2X 3

increases expression

ISO

quercitrin results in increased expression of P2RX3 mRNA

NCBI chr 3:90,487,506...90,531,315
Ensembl chr 3:90,487,506...90,531,794

G

pyrimidinergic receptor P2Y6

decreases expression

ISO

quercitrin results in decreased expression of P2RY6 mRNA

NCBI chr 1:164,707,188...164,742,689
Ensembl chr 1:164,706,116...164,743,588

G

poly (ADP-ribose) polymerase 1

multiple interactions

EXP

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

POZ (BTB) and AT hook containing zinc finger 1

decreases expression

ISO

quercitrin results in decreased expression of PATZ1 mRNA

NCBI chr14:82,378,226...82,396,679
Ensembl chr14:82,377,697...82,396,686

G

peroxisomal biogenesis factor 16

decreases expression

ISO

quercitrin results in decreased expression of PEX16 mRNA

NCBI chr 3:98,800,357...98,808,091
Ensembl chr 3:98,798,654...98,808,630

G

pepsinogen A3

increases expression

ISO

quercitrin results in increased expression of PGA3 mRNA

NCBI chr 1:216,741,935...216,752,067
Ensembl chr 1:216,741,935...216,752,067

G

p53-induced death domain protein 1

increases expression

ISO

quercitrin results in increased expression of PIDD1 mRNA

NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:205,966,392...205,971,600

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

affects expression

ISO

quercitrin affects the expression of PIK3C2A mRNA

NCBI chr 1:180,012,248...180,117,786
Ensembl chr 1:180,012,248...180,117,773

G

phosphoinositide-3-kinase regulatory subunit 1

affects expression

ISO

quercitrin affects the expression of PIK3R1 mRNA

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

phospholipase C, beta 2

affects expression

ISO

quercitrin affects the expression of PLCB2 mRNA

NCBI chr 3:126,134,925...126,158,303
Ensembl chr 3:126,138,736...126,158,221

G

phospholipase C, epsilon 1

affects expression

ISO

quercitrin affects the expression of PLCE1 mRNA

NCBI chr 1:245,655,855...245,964,966
Ensembl chr 1:245,657,080...245,963,828

G

plasminogen receptor with a C-terminal lysine

decreases expression

ISO

quercitrin results in decreased expression of PLGRKT mRNA

NCBI chr 1:236,512,574...236,526,858
Ensembl chr 1:236,512,580...236,524,840

G

POC1 centriolar protein A

decreases expression

ISO

quercitrin results in decreased expression of POC1A mRNA

NCBI chr 8:115,801,335...115,869,812
Ensembl chr 8:115,801,396...115,870,392

G

DNA polymerase eta

increases expression

ISO

quercitrin results in increased expression of POLH mRNA

NCBI chr 9:22,275,929...22,310,576
Ensembl chr 9:22,275,946...22,310,577

G

RNA polymerase mitochondrial

decreases expression

ISO

quercitrin results in decreased expression of POLRMT mRNA

NCBI chr 7:10,610,149...10,620,411
Ensembl chr 7:10,610,198...10,621,205

G

protein-O-mannosyltransferase 2

increases expression

ISO

quercitrin results in increased expression of POMT2 mRNA

NCBI chr 6:112,486,416...112,525,799
Ensembl chr 6:112,486,416...112,525,799

G

POU domain class 5, transcription factor 2

decreases expression

ISO

quercitrin results in decreased expression of POU5F2 mRNA

NCBI chr 2:9,643,313...9,644,547

G

protein kinase C, beta

affects expression

ISO

quercitrin affects the expression of PRKCB mRNA

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

proline rich 3

decreases expression

ISO

quercitrin results in decreased expression of PRR3 mRNA

NCBI chr20:2,797,677...2,804,674
Ensembl chr20:2,797,105...2,798,617

G

pleckstrin and Sec7 domain containing 4

increases expression

ISO

quercitrin results in increased expression of PSD4 mRNA

NCBI chr 3:27,535,341...27,571,850
Ensembl chr 3:27,535,440...27,573,731

G

proteasome 20S subunit alpha 6

decreases expression

ISO

quercitrin results in decreased expression of PSMA6 mRNA

NCBI chr 6:78,500,676...78,531,693
Ensembl chr 6:78,500,736...78,531,717

G

proteasome 20S subunit alpha 8

decreases expression

ISO

quercitrin results in decreased expression of PSMA8 mRNA

NCBI chr18:6,138,226...6,202,802
Ensembl chr18:6,138,226...6,202,802

G

proteasome 20S subunit beta 6

decreases expression

ISO

quercitrin results in decreased expression of PSMB6 mRNA

NCBI chr10:55,737,852...55,740,218
Ensembl chr10:55,737,888...55,740,218

G

proteasome 20S subunit beta 9

decreases expression

ISO

quercitrin results in decreased expression of PSMB9 mRNA

NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,668,739...4,674,421

G

prostaglandin D2 receptor 2

increases expression

ISO

quercitrin results in increased expression of PTGDR2 mRNA

NCBI chr 1:217,010,183...217,015,044
Ensembl chr 1:216,995,629...217,022,393

G

protein tyrosine kinase 2 beta

affects expression

ISO

quercitrin affects the expression of PTK2B mRNA

NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806

G

protein tyrosine phosphatase, receptor type, U

decreases expression

ISO

quercitrin results in decreased expression of PTPRU mRNA

NCBI chr 5:149,234,624...149,308,857
Ensembl chr 5:149,234,624...149,308,833

G

Rac family small GTPase 3

affects expression

ISO

quercitrin affects the expression of RAC3 mRNA

NCBI chr10:106,501,133...106,503,569
Ensembl chr10:106,501,135...106,503,569

G

RAP1A, member of RAS oncogene family

affects expression

ISO

quercitrin affects the expression of RAP1A mRNA

NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808

G

RB-associated KRAB zinc finger

increases expression

ISO

quercitrin results in increased expression of RBAK mRNA

NCBI chr12:16,488,895...16,502,523
Ensembl chr12:16,488,950...16,502,733

G

ribokinase

decreases expression

ISO

quercitrin results in decreased expression of RBKS mRNA

NCBI chr 6:30,467,724...30,544,284
Ensembl chr 6:30,467,726...30,544,294

G

RNA binding motif protein 15B

increases expression

ISO

quercitrin results in increased expression of RBM15B mRNA

NCBI chr 8:116,422,309...116,425,374
Ensembl chr 8:116,421,540...116,425,940

G

RNA binding motif protein 38

increases expression

ISO

quercitrin results in increased expression of RBM38 mRNA

NCBI chr 3:182,219,898...182,232,723
Ensembl chr 3:182,219,899...182,232,714

G

RNA binding motif protein 39

increases expression

ISO

quercitrin results in increased expression of RBM39 mRNA

NCBI chr 3:165,123,087...165,156,453
Ensembl chr 3:165,123,095...165,149,397

G

ring finger and CHY zinc finger domain containing 1

decreases expression

ISO

quercitrin results in decreased expression of RCHY1 mRNA

NCBI chr14:16,397,533...16,413,286
Ensembl chr14:16,397,494...16,413,451

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RIO kinase 1

increases expression

ISO

quercitrin results in increased expression of RIOK1 mRNA

NCBI chr17:26,972,490...26,995,382
Ensembl chr17:26,972,490...26,995,436

G

ring finger protein 14

decreases expression

ISO

quercitrin results in decreased expression of RNF14 mRNA

NCBI chr18:30,381,072...30,406,859
Ensembl chr18:30,382,857...30,406,774

G

Rho-associated coiled-coil containing protein kinase 1

affects expression

ISO

quercitrin affects the expression of ROCK1 mRNA

NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147

G

RT1 class Ia, locus A2

affects expression

ISO

quercitrin affects the expression of HLA-E mRNA

NCBI chr20:4,872,720...4,876,425

G

RT1 class II, locus Ba

affects expression

ISO

quercitrin affects the expression of HLA-DQA1 mRNA

NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,576,843...4,581,653

G

RT1 class I, locus CE16

affects expression

ISO

quercitrin affects the expression of HLA-A mRNA

NCBI chr20:3,261,656...3,265,548

G

Sin3A associated protein 18

increases expression

ISO

quercitrin results in increased expression of SAP18 mRNA

NCBI chr15:36,058,784...36,063,089
Ensembl chr10:87,156,914...87,158,257
Ensembl chr15:87,156,914...87,158,257

G

spermidine/spermine N1-acetyl transferase 1

decreases expression

ISO

quercitrin results in decreased expression of SAT1 mRNA

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:44,006,781...44,011,374

G

SERTA domain containing 1

increases expression

ISO

quercitrin results in increased expression of SERTAD1 mRNA

NCBI chr 1:91,903,297...91,906,565
Ensembl chr 1:91,891,814...91,907,001

G

splicing factor 3b, subunit 1

decreases expression

ISO

quercitrin results in decreased expression of SF3B1 mRNA

NCBI chr 9:63,986,829...64,026,723
Ensembl chr 9:63,986,829...64,026,719

G

solute carrier family 16, member 13

decreases expression

ISO

quercitrin results in decreased expression of SLC16A13 mRNA

NCBI chr10:55,424,633...55,436,555

G

solute carrier family 16, member 4

decreases expression

ISO

quercitrin results in decreased expression of SLC16A4 mRNA

NCBI chr 2:197,593,738...197,621,569
Ensembl chr 2:197,599,295...197,621,562

G

solute carrier family 22, member 18

decreases expression

ISO

quercitrin results in decreased expression of SLC67A1 mRNA

NCBI chr 1:208,100,032...208,124,382
Ensembl chr 1:208,101,136...208,124,380

G

solute carrier family 25, member 40

decreases expression

ISO

quercitrin results in decreased expression of SLC25A40 mRNA

NCBI chr 4:26,544,288...26,631,439
Ensembl chr 4:26,544,290...26,631,383

G

solute carrier family 39 member 8

decreases expression

ISO

quercitrin results in decreased expression of SLC39A8 mRNA

NCBI chr 2:226,845,686...226,992,668
Ensembl chr 2:226,929,644...226,992,667

G

solute carrier family 7 member 9

increases expression

ISO

quercitrin results in increased expression of SLC7A9 mRNA

NCBI chr 1:97,246,253...97,269,546
Ensembl chr 1:97,247,547...97,269,543

G

schlafen-like 1

increases expression

ISO

quercitrin results in increased expression of SLFNL1 mRNA

NCBI chr 5:139,402,861...139,407,332
Ensembl chr 5:139,403,672...139,407,332

G

SMAD family member 3

increases expression

ISO

quercitrin results in increased expression of SMAD3 mRNA

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

sphingomyelin phosphodiesterase 1

increases expression

ISO

quercitrin results in increased expression of SMPD1 mRNA

NCBI chr 1:169,304,772...169,308,615
Ensembl chr 1:169,304,708...169,308,614

G

snail family transcriptional repressor 2

affects expression

ISO

quercitrin affects the expression of SNAI2 mRNA

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349

G

sorbin and SH3 domain containing 1

affects expression

ISO

quercitrin affects the expression of SORBS1 mRNA

NCBI chr 1:249,057,324...249,279,703
Ensembl chr 1:249,057,324...249,279,608

G

sortilin related receptor 1

decreases expression

ISO

quercitrin results in decreased expression of SORL1 mRNA

NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:51,238,722...51,401,446

G

Sp4 transcription factor

increases expression

ISO

quercitrin results in increased expression of SP4 mRNA

NCBI chr 6:145,330,416...145,395,750
Ensembl chr 6:145,330,416...145,395,146

G

spermatogenesis associated 18

increases expression

ISO

quercitrin results in increased expression of SPATA18 mRNA

NCBI chr14:34,885,995...34,912,704
Ensembl chr14:34,885,995...34,912,736

G

SRC proto-oncogene, non-receptor tyrosine kinase

affects expression

ISO

quercitrin affects the expression of SRC mRNA

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

steroid 5 alpha-reductase 3

increases expression

ISO

quercitrin results in increased expression of SRD5A3 mRNA

NCBI chr14:32,400,603...32,414,987
Ensembl chr14:32,400,603...32,415,117

G

serine/arginine repetitive matrix 2

increases expression

ISO

quercitrin results in increased expression of SRRM2 mRNA

NCBI chr10:13,320,059...13,353,337
Ensembl chr10:13,320,059...13,353,337

G

succinylCoA:glutarate-CoA transferase

increases expression

ISO

quercitrin results in increased expression of SUGCT mRNA

NCBI chr17:52,072,012...52,929,852
Ensembl chr17:52,072,052...52,930,281

G

SURP and G patch domain containing 1

increases expression

ISO

quercitrin results in increased expression of SUGP1 mRNA

NCBI chr16:19,386,588...19,417,460
Ensembl chr16:19,386,589...19,417,460

G

transcription elongation factor A1

decreases expression

ISO

quercitrin results in decreased expression of TCEA1 mRNA

NCBI chr 5:19,414,351...19,466,629
Ensembl chr15:12,831,339...12,834,156
Ensembl chr 5:12,831,339...12,834,156

G

transcription elongation factor A2

decreases expression

ISO

quercitrin results in decreased expression of TCEA2 mRNA

NCBI chr 3:189,173,756...189,181,633
Ensembl chr 3:189,165,603...189,182,540

G

transcription factor 7

affects expression

ISO

quercitrin affects the expression of TCF7 mRNA

NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,924,363...36,954,279

G

transcription factor B1, mitochondrial

decreases expression

ISO

quercitrin results in decreased expression of TFB1M mRNA

NCBI chr 1:46,520,510...46,567,004
Ensembl chr 1:46,524,435...46,566,948

G

TGFB-induced factor homeobox 2

decreases expression

ISO

quercitrin results in decreased expression of TGIF2 mRNA

NCBI chr 3:165,791,101...165,808,669
Ensembl chr 3:165,793,480...165,808,666

G

transglutaminase 2

decreases expression

ISO

quercitrin results in decreased expression of TGM2 mRNA

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:167,192,612...167,304,240

G

thrombospondin type 1 domain containing 1

increases expression

ISO

quercitrin results in increased expression of THSD1 mRNA

NCBI chr16:76,473,026...76,507,404
Ensembl chr16:76,473,859...76,503,951

G

transmembrane protein 160

decreases expression

ISO

quercitrin results in decreased expression of TMEM160 mRNA

NCBI chr 1:86,292,582...86,295,290
Ensembl chr 1:86,292,753...86,297,780

G

transmembrane protein 208

decreases expression

ISO

quercitrin results in decreased expression of TMEM208 mRNA

NCBI chr19:50,113,494...50,116,210
Ensembl chr19:50,113,510...50,124,153

G

transmembrane protein 242

increases expression

ISO

quercitrin results in increased expression of TMEM242 mRNA

NCBI chr 1:48,397,865...48,424,639
Ensembl chr 1:48,397,865...48,424,633

G

thioredoxin-related transmembrane protein 1

decreases expression

ISO

quercitrin results in decreased expression of TMX1 mRNA

NCBI chr 6:94,696,699...94,707,751
Ensembl chr 6:94,696,358...94,708,618

G

tumor necrosis factor

multiple interactions

EXP

quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of BAX protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] affects the localization of RELA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased cleavage of PARP1 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of CASP3 protein]; quercitrin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 1A

decreases expression

ISO

quercitrin results in decreased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF receptor superfamily member 1B

decreases expression

ISO

quercitrin results in decreased expression of TNFRSF1B mRNA

NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411

G

tumor protein p63

decreases expression

ISO

quercitrin results in decreased expression of TP63 mRNA

NCBI chr11:88,343,647...88,554,543
Ensembl chr11:88,343,651...88,554,177

G

tetraspanin 14

decreases expression

ISO

quercitrin results in decreased expression of TSPAN14 mRNA

NCBI chr16:16,818,344...16,875,462
Ensembl chr16:16,818,344...16,875,674

G

U2 small nuclear RNA auxiliary factor 2

increases expression

ISO

quercitrin results in increased expression of U2AF2 mRNA

NCBI chr 1:77,789,752...77,807,307
Ensembl chr 1:77,789,752...77,807,413

G

urotensin 2 receptor

increases expression

ISO

quercitrin results in increased expression of UTS2R mRNA

NCBI chr10:106,936,398...106,937,558
Ensembl chr10:106,932,325...106,938,056

G

vomeronasal 1 receptor 51

increases expression

ISO

quercitrin results in increased expression of VN1R1 mRNA

G

von Willebrand factor A domain containing 8

decreases expression

ISO

quercitrin results in decreased expression of VWA8 mRNA

NCBI chr15:60,661,764...60,985,971
Ensembl chr15:60,661,877...60,985,971

G

WASP actin nucleation promoting factor

affects expression

ISO

quercitrin affects the expression of WAS mRNA

NCBI chr X:17,077,057...17,085,802
Ensembl chr X:17,073,314...17,085,802

G

WD repeat domain 33

decreases expression

ISO

quercitrin results in decreased expression of WDR33 mRNA

NCBI chr18:23,706,708...23,812,985
Ensembl chr18:23,706,602...23,809,708

G

WW domain-containing oxidoreductase

decreases expression

ISO

quercitrin results in decreased expression of WWOX mRNA

NCBI chr19:59,338,402...60,269,323
Ensembl chr19:59,341,233...60,269,441

G

zonadhesin

increases expression

ISO

quercitrin results in increased expression of ZAN mRNA

NCBI chr12:24,851,798...24,963,837
Ensembl chr12:24,851,807...24,964,559

G

zinc finger CCHC-type containing 14

increases expression

ISO

quercitrin results in increased expression of ZCCHC14 mRNA

NCBI chr19:66,582,800...66,627,136
Ensembl chr19:66,582,800...66,627,136

G

zinc finger protein 502

increases expression

ISO

quercitrin results in increased expression of ZNF502 mRNA

NCBI chr 1:30,712,974...30,737,956

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

allograft inflammatory factor 1

multiple interactions

ISO

sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein]

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

dorsomorphin inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; Sirolimus inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]; sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

dorsomorphin inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; Sirolimus inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]; sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions

ISO

sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

cadherin 1

decreases expression

ISO

sophoricoside results in decreased expression of CDH1

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

estrogen receptor 1

decreases expression

ISO

sophoricoside results in decreased expression of ESR1

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

interleukin 6

multiple interactions

ISO

sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL6 mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin subunit beta 3

decreases expression

ISO

sophoricoside results in decreased expression of ITGB3

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800

G

matrix metallopeptidase 2

decreases expression

ISO

sophoricoside results in decreased expression of MMP2

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

mechanistic target of rapamycin kinase

multiple interactions

ISO

sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

NFKB inhibitor alpha

multiple interactions

ISO

sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of and results in increased phosphorylation of NFKBIA protein]; sophoricoside inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions

ISO

sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

progesterone receptor

increases expression

ISO

sophoricoside results in increased expression of PGR

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PTGS2 mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased phosphorylation of RELA protein]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

tyrosine hydroxylase

multiple interactions

ISO

sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

tumor necrosis factor

multiple interactions

ISO

sophoricoside inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; sophoricoside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
role	20844
biological role	20831
biochemical role	19888
enzyme inhibitor	18710
EC 1.* (oxidoreductase) inhibitor	17657
EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor	16233
EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor	915
EC 1.14.18.1 (tyrosinase) inhibitor +	915

paths to the root