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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor
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Accession:CHEBI:76843 term browser browse the term
Definition:An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme with reduced iron-sulfur protein as one donor and incorporating one atom of oxygen (EC 1.14.15.*).
Synonyms:related_synonym: EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitors;   EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen) inhibitors;   EC 1.14.15.* inhibitor;   EC 1.14.15.* inhibitors;   oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen (EC 1.14.15.*) inhibitor


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metyrapone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
increases activity
multiple interactions 		ISO Metyrapone results in increased expression of ABCC3 mRNA
Metyrapone results in increased activity of ABCC3 protein
[Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA 		CTD PMID:14570758 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of ATF6 protein] CTD PMID:19819344 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Casp4 caspase 4 multiple interactions ISO [Metyrapone co-treated with Vitamin K 3] affects the localization of CASP4 protein CTD PMID:19819344 NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of CCL2 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of CCL2 protein] CTD PMID:27037194 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of CEBPB mRNA CTD PMID:37088303 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of CXCL1 protein] CTD PMID:27037194 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA] CTD PMID:16935330 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] CTD PMID:16935330 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein] CTD PMID:11856816 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:18669584 NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression 		EXP Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Cyclophosphamide]; Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Ifosfamide]
Metyrapone results in increased expression of CYP2B1 mRNA 		CTD PMID:7834628 PMID:16125621 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Metyrapone results in increased expression of CYP2B2 mRNA CTD PMID:16125621 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein] CTD PMID:11856816 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions 		ISO Metyrapone results in increased expression of CYP3A4 mRNA
[Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA 		CTD PMID:10219967 PMID:12505310 PMID:17041008 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Metyrapone co-treated with Metyrapone] results in increased expression of DDIT3 protein; Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of DDIT3 protein] CTD PMID:19819344 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Metyrapone CTD PMID:24246760 NCBI chr 6:97,068,149...97,083,744
Ensembl chr 6:97,068,149...97,083,744 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of FOS mRNA CTD PMID:37088303 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of HIF3A mRNA] CTD PMID:27037194 NCBI chr 1:86,846,196...86,878,527
Ensembl chr 1:86,850,554...86,877,838 		JBrowse link
G Hk2 hexokinase 2 multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of HK2 mRNA CTD PMID:37088303 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of HMOX1 mRNA] CTD PMID:27037194 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity ISO Metyrapone results in decreased activity of HSD11B1 protein CTD PMID:10664531 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Metyrapone results in decreased activity of HSD11B2 protein CTD PMID:10664531 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression
multiple interactions 		ISO Metyrapone results in decreased expression of HSD17B1 mRNA
[Colforsin co-treated with Metyrapone] results in decreased expression of HSD17B1 mRNA 		CTD PMID:16935330 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression 		ISO [Colforsin co-treated with Metyrapone] results in decreased expression of HSD3B2 mRNA
Metyrapone results in decreased expression of HSD3B2 mRNA 		CTD PMID:16935330 NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:188,784,614...188,790,569 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of HSPA5 protein] CTD PMID:19819344 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of IGFBP1 mRNA CTD PMID:37088303 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of IL10 protein] CTD PMID:27037194 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of IL17A protein] CTD PMID:27037194 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of IL6 protein] CTD PMID:27037194 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased phosphorylation of IRS1 protein CTD PMID:37088303 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] affects the expression of JUN mRNA CTD PMID:37088303 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of KRAS mRNA CTD PMID:37088303 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Lep leptin multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of LEP mRNA CTD PMID:37088303 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lepr leptin receptor increases expression EXP Metyrapone increases Lepr mRNA expression in placenta RGD PMID:12297537 RGD:10412034 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Metyrapone co-treated with Vitamin K 3] results in increased expression of MAP1LC3B protein CTD PMID:19819344 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mt1a metallothionein 1A multiple interactions EXP Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of MT1 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of MT1 mRNA] CTD PMID:27037194 PMID:31520820 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity 		ISO [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:14570758 PMID:16919048 PMID:17041008 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Metyrapone results in increased activity of NR1I3 protein CTD PMID:16919048 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in decreased expression of PCK2 mRNA CTD PMID:37088303 NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of PGK1 mRNA CTD PMID:37088303 NCBI chr  X:75,336,988...75,352,962
Ensembl chr  X:75,336,687...75,352,959 		JBrowse link
G Pomc proopiomelanocortin increases expression ISO
EXP 		Metyrapone results in increased expression of POMC protein CTD PMID:638031 PMID:16566900 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of SERPINE1 mRNA CTD PMID:37088303 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions EXP Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of SGK1 mRNA] CTD PMID:31520820 NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231 		JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of SHC1 mRNA CTD PMID:37088303 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		Metyrapone inhibits the reaction [Cocaine results in increased expression of TNF protein]
Metyrapone inhibits the reaction [Ozone results in increased expression of TNF mRNA] 		CTD PMID:11856816 PMID:27037194 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions EXP Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of TSC22D3 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of TSC22D3 mRNA] CTD PMID:27037194 PMID:31520820 NCBI chr  X:109,006,410...109,066,389
Ensembl chr  X:109,006,420...109,015,519 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of VEGFA mRNA CTD PMID:37088303 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        biochemical role 19888
          enzyme inhibitor 18710
            EC 1.* (oxidoreductase) inhibitor 17657
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 16233
                EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor 47
                  EC 1.14.15.3 (alkane 1-monooxygenase) inhibitor + 0
                  EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor + 47
                  EC 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving) inhibitor + 0
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