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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor
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Accession:CHEBI:76843 term browser browse the term
Definition:An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme with reduced iron-sulfur protein as one donor and incorporating one atom of oxygen (EC 1.14.15.*).
Synonyms:related_synonym: EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitors;   EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen) inhibitors;   EC 1.14.15.* inhibitor;   EC 1.14.15.* inhibitors;   oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen (EC 1.14.15.*) inhibitor


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metyrapone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
increases activity
multiple interactions		 ISO Metyrapone results in increased expression of ABCC3 mRNA
Metyrapone results in increased activity of ABCC3 protein
[Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA		 CTD PMID:14570758 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of ATF6 protein] CTD PMID:19819344 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Casp4 caspase 4 multiple interactions ISO [Metyrapone co-treated with Vitamin K 3] affects the localization of CASP4 protein CTD PMID:19819344 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of CCL2 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of CCL2 protein] CTD PMID:27037194 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of CEBPB mRNA CTD PMID:37088303 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of CXCL1 protein] CTD PMID:27037194 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA] CTD PMID:16935330 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] CTD PMID:16935330 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein] CTD PMID:11856816 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions ISO Metyrapone inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:18669584 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression		 EXP Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Cyclophosphamide]; Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Ifosfamide]
Metyrapone results in increased expression of CYP2B1 mRNA		 CTD PMID:7834628 PMID:16125621 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Metyrapone results in increased expression of CYP2B2 mRNA CTD PMID:16125621 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO Metyrapone inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein] CTD PMID:11856816 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO Metyrapone results in increased expression of CYP3A4 mRNA
[Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:10219967 PMID:12505310 PMID:17041008 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [Metyrapone co-treated with Metyrapone] results in increased expression of DDIT3 protein; Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of DDIT3 protein] CTD PMID:19819344 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of Metyrapone CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of FOS mRNA CTD PMID:37088303 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of HIF3A mRNA] CTD PMID:27037194 NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758 		JBrowse link
G Hk2 hexokinase 2 multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of HK2 mRNA CTD PMID:37088303 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of HMOX1 mRNA] CTD PMID:27037194 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity ISO Metyrapone results in decreased activity of HSD11B1 protein CTD PMID:10664531 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Metyrapone results in decreased activity of HSD11B2 protein CTD PMID:10664531 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression
multiple interactions		 ISO Metyrapone results in decreased expression of HSD17B1 mRNA
[Colforsin co-treated with Metyrapone] results in decreased expression of HSD17B1 mRNA		 CTD PMID:16935330 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression		 ISO [Colforsin co-treated with Metyrapone] results in decreased expression of HSD3B2 mRNA
Metyrapone results in decreased expression of HSD3B2 mRNA		 CTD PMID:16935330 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Metyrapone promotes the reaction [Vitamin K 3 results in increased expression of HSPA5 protein] CTD PMID:19819344 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of IGFBP1 mRNA CTD PMID:37088303 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of IL10 protein] CTD PMID:27037194 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of IL17A protein] CTD PMID:27037194 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Metyrapone inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of IL6 protein] CTD PMID:27037194 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased phosphorylation of IRS1 protein CTD PMID:37088303 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] affects the expression of JUN mRNA CTD PMID:37088303 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of KRAS mRNA CTD PMID:37088303 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lep leptin multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of LEP mRNA CTD PMID:37088303 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor increases expression EXP Metyrapone increases Lepr mRNA expression in placenta RGD PMID:12297537 RGD:10412034 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Metyrapone co-treated with Vitamin K 3] results in increased expression of MAP1LC3B protein CTD PMID:19819344 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of MT1 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of MT1 mRNA] CTD PMID:27037194 PMID:31520820 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:14570758 PMID:16919048 PMID:17041008 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Metyrapone results in increased activity of NR1I3 protein CTD PMID:16919048 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in decreased expression of PCK2 mRNA CTD PMID:37088303 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of PGK1 mRNA CTD PMID:37088303 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Pomc proopiomelanocortin increases expression ISO
EXP		 Metyrapone results in increased expression of POMC protein CTD PMID:638031 PMID:16566900 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of SERPINE1 mRNA CTD PMID:37088303 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions EXP Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of SGK1 mRNA] CTD PMID:31520820 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of SHC1 mRNA CTD PMID:37088303 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Metyrapone inhibits the reaction [Cocaine results in increased expression of TNF protein]
Metyrapone inhibits the reaction [Ozone results in increased expression of TNF mRNA]		 CTD PMID:11856816 PMID:27037194 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions EXP Metyrapone inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of TSC22D3 mRNA]; Metyrapone inhibits the reaction [Ozone results in increased expression of TSC22D3 mRNA] CTD PMID:27037194 PMID:31520820 NCBI chr  X:104,217,898...104,277,886
Ensembl chr  X:104,217,925...104,276,861 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of VEGFA mRNA CTD PMID:37088303 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          enzyme inhibitor 18744
            EC 1.* (oxidoreductase) inhibitor 17530
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 15965
                EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor 47
                  EC 1.14.15.3 (alkane 1-monooxygenase) inhibitor + 0
                  EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor + 47
                  EC 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving) inhibitor + 0
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