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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bopindolol
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Accession:CHEBI:76749 term browser browse the term
Definition:A racemate comprising of equal amounts of (R)-bopindolol and (S)-bopindolol. It is a non-selective antagonist of beta1- and beta2-adrenoceptors and a prodrug in which the ester group is hydrolysed to form the corresponding hydroxy derivative.
Synonyms:exact_synonym: rac-1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate
 related_synonym: (+-)-1-[(1,1-Dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-2-propanol benzoate;   (RS)-bopindolol;   LT 31-200;   Sandonorm;   bopindololum;   rac-bopindolol;   racemic bopindolol
 xref: CAS:62658-63-3;   Chemspider:40146;   DrugBank:DB08807;   Drug_Central:389;   HMDB:HMDB0015696;   KEGG:D07537;   LINCS:LSM-45796
 xref_mesh: MESH:C036007
 xref: PMID:10474078;   PMID:11314603;   PMID:11906483;   PMID:12008130;   PMID:14656606;   PMID:1681490;   PMID:22477063;   PMID:2439815;   PMID:2568836;   PMID:32888198;   PMID:6127218;   PMID:7474556;   PMID:7902696;   PMID:8097742;   PMID:8535397;   PMID:9730775;   Wikipedia:Bopindolol


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bopindolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO bopindolol results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO bopindolol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    chemical entity 19865
      chemical substance 14397
        mixture 13713
          racemate 12091
            bopindolol 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organochalcogen compound 19273
                                organooxygen compound 19189
                                  carbon oxoacid 18660
                                    carboxylic acid 18657
                                      aromatic carboxylic acid 12729
                                        benzoic acids 12707
                                          benzoate ester 5739
                                            1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate 2
                                              (R)-bopindolol 2
                                                bopindolol 2
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