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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:imidazoquinoxaline
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Accession:CHEBI:76605 term browser browse the term
Definition:Any organic heterotricyclic compound with a skeleton consisting of an imidazole ring ortho-fused to a quinoxaline.
Synonyms:related_synonym: imidazoquinoxalines


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MeIQx term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1A protein affects the transport of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:18322075 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ABCC9 mRNA CTD PMID:20816883 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356 		JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ABCD3 mRNA CTD PMID:20816883 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport ISO ABCG2 protein affects the transport of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:18322075 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ACSS1 mRNA CTD PMID:20816883 NCBI chr 3:139,450,383...139,500,325
Ensembl chr 3:139,450,383...139,500,325 		JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ADORA2B mRNA CTD PMID:20816883 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Adss2 adenylosuccinate synthase 2 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ADSS2 mRNA CTD PMID:20816883 NCBI chr13:89,769,240...89,799,577
Ensembl chr13:89,769,244...89,799,604 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression		 ISO AHR mutant form inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of AHR protein		 CTD PMID:20816883 PMID:27644595 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT1 protein CTD PMID:37005939 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT2 protein CTD PMID:37005939 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions ISO [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Insulin] results in decreased phosphorylation of AKT3 protein CTD PMID:37005939 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ALDH3A1 mRNA CTD PMID:20816883 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Anln anillin, actin binding protein increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ANLN mRNA CTD PMID:20816883 NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of APAF1 mRNA CTD PMID:20816883 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Arg1 arginase 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ARG1 mRNA CTD PMID:20816883 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator affects response to substance ISO ARNT protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:23208499 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ASAP1 mRNA CTD PMID:20816883 NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754 		JBrowse link
G Atp11b ATPase phospholipid transporting 11B (putative) increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ATP11B mRNA CTD PMID:20816883 NCBI chr 2:118,585,348...118,691,076
Ensembl chr 2:118,585,342...118,690,232 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of BAX mRNA CTD PMID:23810796 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of BCL2 mRNA; 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of BCL2 protein CTD PMID:23810796 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G C1qtnf7 C1q and TNF related 7 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of C1QTNF7 mRNA CTD PMID:20816883 NCBI chr14:67,467,888...67,580,477
Ensembl chr14:67,468,014...67,580,410 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CACNA1D mRNA CTD PMID:20816883 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased activity of CASP3 protein
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased activity of CASP3 protein		 CTD PMID:20307560 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CASP8 mRNA CTD PMID:20816883 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccdc47 coiled-coil domain containing 47 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CCDC47 mRNA CTD PMID:20816883 NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL2 mRNA CTD PMID:23681119 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL3 mRNA CTD PMID:23681119 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL4 mRNA CTD PMID:23681119 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL7 mRNA CTD PMID:23681119 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNA2 mRNA CTD PMID:23681119 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNB1 mRNA CTD PMID:23681119 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnb2 cyclin B2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNB2 mRNA CTD PMID:23681119 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCND1 mRNA CTD PMID:23681119 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCNE1 mRNA CTD PMID:23681119 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCR2 mRNA CTD PMID:23681119 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCR7 mRNA CTD PMID:23681119 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDC25C mRNA CTD PMID:20816883 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
multiple interactions		 ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDK1 mRNA
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CDK1 mRNA		 CTD PMID:20816883 PMID:23681119 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk13 cyclin-dependent kinase 13 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDK13 mRNA CTD PMID:20816883 NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDKN1A mRNA; 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDKN1A protein CTD PMID:23810796 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases phosphorylation
affects response to substance		 ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased phosphorylation of CEBPB protein
CEBPB protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline		 CTD PMID:23208499 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cep55 centrosomal protein 55 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CEP55 mRNA CTD PMID:20816883 NCBI chr 1:235,832,823...235,848,401
Ensembl chr 1:235,832,878...235,848,394 		JBrowse link
G Cfap45 cilia and flagella associated protein 45 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CFAP45 mRNA CTD PMID:20816883 NCBI chr13:84,989,474...85,012,880
Ensembl chr13:84,981,728...85,012,878 		JBrowse link
G Cfhr4 complement factor H-related 4 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CFHR4 mRNA CTD PMID:20816883 NCBI chr13:51,422,592...51,491,476
Ensembl chr13:51,422,592...51,491,502 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CHEK1 mRNA CTD PMID:23681119 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Cldn14 claudin 14 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CLDN14 mRNA CTD PMID:20816883 NCBI chr11:33,232,281...33,329,440
Ensembl chr11:33,232,220...33,329,171 		JBrowse link
G Clybl citramalyl-CoA lyase decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CLYBL mRNA CTD PMID:20816883 NCBI chr15:99,283,644...99,505,697
Ensembl chr15:99,283,650...99,505,695 		JBrowse link
G Col9a2 collagen type IX alpha 2 chain increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of COL9A2 mRNA CTD PMID:20816883 NCBI chr 5:134,607,616...134,624,678
Ensembl chr 5:134,607,616...134,624,677 		JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CSGALNACT1 mRNA CTD PMID:20816883 NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
affects activity
increases expression		 ISO [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of CYP1A1 mRNA; AHR mutant form inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A1 mRNA]
CYP1A1 affects the activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A1 mRNA		 CTD PMID:2334931 PMID:20307560 PMID:20816883 PMID:22138251 PMID:23681119 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
affects metabolic processing
increases activity
increases oxidation
increases expression
affects oxidation		 ISO
EXP		 [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; [CYP1A2 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] which results in increased chemical synthesis of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline metabolite; [CYP1A2 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] which results in increased chemical synthesis of 2-amino-4-hydroxymethyl-3,8-dimethylimidazo(4,5-f)quinoxaline; AHR mutant form inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; xanthohumol inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]
CYP1A2 protein results in decreased activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
CYP1A2 protein affects the metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased activity of CYP1A2 protein; CYP1A2 results in increased activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
CYP1A2 protein results in increased oxidation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; CYP1A2 results in increased oxidation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA; 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 protein
CYP1A2 affects the oxidation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline promotes the reaction [Carbon Tetrachloride results in decreased expression of CYP1A2 protein]; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with alpha-naphthoflavone] results in increased expression of CYP1A2 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 protein; [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with Carbon Tetrachloride] results in increased expression of CYP1A2 mRNA; LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 protein]
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA; [Phenobarbital co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1A2 mRNA		 CTD PMID:2334931 PMID:2655891 PMID:9202738 PMID:9581821 PMID:10503887 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
multiple interactions
affects response to substance		 ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1B1 mRNA
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP1B1 mRNA
CYP1B1 protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline		 CTD PMID:19223546 PMID:20307560 PMID:20816883 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions EXP CYP2A3 protein results in increased metabolism of and results in increased activity of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:8403195 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CYP2B10 mRNA CTD PMID:23681119 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP2C11 mRNA CTD PMID:14965361 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CYP2C8 mRNA CTD PMID:20816883
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of CYP7B1 mRNA CTD PMID:23681119 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Dapl1 death associated protein-like 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DAPL1 mRNA CTD PMID:20816883 NCBI chr 3:43,960,993...43,980,940
Ensembl chr 3:43,960,810...43,980,940 		JBrowse link
G Ddx42 DEAD-box helicase 42 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DDX42 mRNA CTD PMID:20816883 NCBI chr10:91,148,926...91,180,940
Ensembl chr10:91,148,254...91,180,939 		JBrowse link
G Dhrs2 dehydrogenase/reductase 2 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of DHRS2 mRNA CTD PMID:20816883 NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644 		JBrowse link
G Diaph3 diaphanous-related formin 3 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DIAPH3 mRNA CTD PMID:20816883 NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975 		JBrowse link
G Dmxl2 Dmx-like 2 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of DMXL2 mRNA CTD PMID:20816883 NCBI chr 8:54,741,164...54,884,948
Ensembl chr 8:54,741,160...54,885,161 		JBrowse link
G Duox2 dual oxidase 2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DUOX2 mRNA CTD PMID:20816883 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Dusp16 dual specificity phosphatase 16 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of DUSP16 mRNA CTD PMID:20816883 NCBI chr 4:167,546,780...167,630,173
Ensembl chr 4:167,548,155...167,629,980 		JBrowse link
G E2f7 E2F transcription factor 7 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of E2F7 mRNA CTD PMID:20816883 NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734 		JBrowse link
G Egr1 early growth response 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of EGR1 mRNA CTD PMID:20816883 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eps8l3 EPS8 like 3 affects response to substance ISO EPS8L3 protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:19223546 NCBI chr 2:195,514,692...195,528,085
Ensembl chr 2:195,514,692...195,528,085 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ERCC1 mRNA CTD PMID:22100608 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ERCC6L mRNA CTD PMID:20816883 NCBI chr  X:67,245,414...67,261,222
Ensembl chr  X:67,245,414...67,280,756 		JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ESCO2 mRNA CTD PMID:20816883 NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases activity		 ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased activity of ESR1 protein		 CTD PMID:16533016 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Exo1 exonuclease 1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of EXO1 mRNA CTD PMID:23681119 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of FHIT mRNA CTD PMID:22100608 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions		 ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of FOS mRNA
[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of FOS mRNA		 CTD PMID:20816883 PMID:23681119 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation
increases expression		 ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased phosphorylation of FOXO1 protein
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of FOXO1 mRNA		 CTD PMID:37005939 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Fsd1 fibronectin type III and SPRY domain containing 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of FSD1 mRNA CTD PMID:20816883 NCBI chr 9:818,241...821,761
Ensembl chr 9:818,263...828,185 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of G6PC1 mRNA CTD PMID:37005939 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gabpb1 GA binding protein transcription factor subunit beta 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of GABPB1 mRNA CTD PMID:20816883 NCBI chr 3:113,879,972...113,924,742
Ensembl chr 3:113,879,973...113,923,696 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of GADD45A mRNA CTD PMID:23810796 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gjc3 gap junction protein, gamma 3 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of GJC3 mRNA CTD PMID:20816883 NCBI chr12:16,899,846...16,912,309
Ensembl chr12:16,896,813...16,964,246 		JBrowse link
G Gnat1 G protein subunit alpha transducin 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of GNAT1 mRNA CTD PMID:20816883 NCBI chr 8:108,350,935...108,355,671
Ensembl chr 8:108,350,935...108,355,671 		JBrowse link
G Gnmt glycine N-methyltransferase decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of GNMT mRNA CTD PMID:20816883 PMID:22100608 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Gpatch1 G patch domain containing 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of GPATCH1 mRNA CTD PMID:20816883 NCBI chr 1:87,925,606...87,974,544
Ensembl chr 1:87,925,618...87,974,544 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of GSTA1 mRNA CTD PMID:22138251 PMID:23810796 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:22564066 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance ISO GSTP1 protein affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:19223546 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects response to substance ISO GSTT1 gene polymorphism affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:22564066 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of H2AX protein modified form CTD PMID:28160022 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of H6PD mRNA CTD PMID:20816883 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171 		JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of HIPK3 mRNA CTD PMID:20816883 NCBI chr 3:90,796,980...90,866,701
Ensembl chr 3:90,800,296...90,867,759 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of HMOX1 mRNA
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of HMOX1 mRNA		 CTD PMID:20307560 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of HPRT1 gene CTD PMID:12467141 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases mutagenesis EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of HRAS gene CTD PMID:2009133 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of IL1B mRNA CTD PMID:23681119 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il36b interleukin 36, beta multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of IL36B mRNA CTD PMID:23681119 NCBI chr 3:7,024,881...7,030,388
Ensembl chr 3:7,021,973...7,031,619 		JBrowse link
G Il3ra interleukin 3 receptor subunit alpha increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of IL3RA mRNA CTD PMID:20816883 NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484 		JBrowse link
G Impg2 interphotoreceptor matrix proteoglycan 2 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of IMPG2 mRNA CTD PMID:20816883 NCBI chr11:44,318,836...44,418,382
Ensembl chr11:44,318,836...44,418,382 		JBrowse link
G Incenp inner centromere protein increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of INCENP mRNA CTD PMID:20816883 NCBI chr 1:206,520,655...206,550,575
Ensembl chr 1:206,523,380...206,553,265 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of INPP5D mRNA CTD PMID:20816883 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of JUN mRNA CTD PMID:23681119 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcnv1 potassium voltage-gated channel modifier subfamily V member 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KCNV1 mRNA CTD PMID:20816883 NCBI chr 7:76,260,695...76,269,170
Ensembl chr 7:76,260,695...76,269,170 		JBrowse link
G Kctd2 potassium channel tetramerization domain containing 2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KCTD2 mRNA CTD PMID:20816883 NCBI chr10:100,663,013...100,674,756
Ensembl chr10:100,662,884...100,674,336 		JBrowse link
G Kif1b kinesin family member 1B increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KIF1B mRNA CTD PMID:20816883 NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Kifc1 kinesin family member C1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of KIFC1 mRNA CTD PMID:20816883 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105 		JBrowse link
G Klf1 KLF transcription factor 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KLF1 mRNA CTD PMID:20816883 NCBI chr19:23,250,627...23,253,802
Ensembl chr19:23,250,631...23,253,758 		JBrowse link
G Klf6 KLF transcription factor 6 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of KLF6 mRNA CTD PMID:20816883 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570 		JBrowse link
G Knl1 kinetochore scaffold 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of KNL1 mRNA CTD PMID:20816883 NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis EXP 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of KRAS gene CTD PMID:18271921 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lama1 laminin subunit alpha 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of LAMA1 mRNA CTD PMID:20816883 NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478 		JBrowse link
G Lif LIF, interleukin 6 family cytokine decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of LIF mRNA CTD PMID:20816883 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Lrrc58 leucine rich repeat containing 58 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of LRRC58 mRNA CTD PMID:20816883 NCBI chr11:62,850,507...62,862,829
Ensembl chr11:62,847,562...62,862,829 		JBrowse link
G Ltf lactotransferrin multiple interactions EXP LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; LTF protein inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 protein] CTD PMID:12079509 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795 		JBrowse link
G Mat2a methionine adenosyltransferase 2A increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of MAT2A mRNA CTD PMID:20816883 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of MKI67 mRNA CTD PMID:20816883 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of CYTB mRNA CTD PMID:20816883 NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278 		JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions
increases response to substance
increases acetylation
affects activity		 ISO
EXP		 [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline affects the activity of NAT2 polymorphism] which affects the chemical synthesis of Glucose; [CYP3A7 co-treated with NAT2] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NAT2 mRNA; NAT2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
[Phenobarbital co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of NAT2 mRNA
NAT2 protein results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
NAT2 protein results in increased acetylation of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline		 CTD PMID:7625840 PMID:19666988 PMID:22138251 PMID:23681119 PMID:28160022 More... NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nek2 NIMA-related kinase 2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of NEK2 mRNA CTD PMID:20816883 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions		 ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of NFE2L2 mRNA
[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of NFE2L2 mRNA		 CTD PMID:20307560 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NFKB2 mRNA CTD PMID:23681119 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nmu neuromedin U increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of NMU mRNA CTD PMID:20816883 NCBI chr14:31,844,564...31,872,196
Ensembl chr14:31,844,728...31,872,192 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of NR0B2 mRNA CTD PMID:20816883 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Oat ornithine aminotransferase multiple interactions ISO [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:9581821 PMID:10503888 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ORC1 mRNA CTD PMID:20816883 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of PCK1 mRNA CTD PMID:37005939 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pdzd7 PDZ domain containing 7 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PDZD7 mRNA CTD PMID:20816883 NCBI chr 1:243,888,295...243,907,778
Ensembl chr 1:243,888,281...243,906,839 		JBrowse link
G Pgm5 phosphoglucomutase 5 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PGM5 mRNA CTD PMID:20816883 NCBI chr 1:222,325,638...222,513,434
Ensembl chr 1:222,325,643...222,513,437 		JBrowse link
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PIM2 mRNA CTD PMID:22100608 NCBI chr  X:14,617,582...14,622,851
Ensembl chr  X:14,617,582...14,622,851 		JBrowse link
G Pip5kl1 phosphatidylinositol-4-phosphate 5-kinase-like 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PIP5KL1 mRNA CTD PMID:20816883 NCBI chr 3:15,860,493...15,869,264
Ensembl chr 3:15,855,946...15,869,165 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:9581821 PMID:10503888 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Poted POTE ankyrin domain family member D increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of POTED mRNA CTD PMID:20816883 NCBI chr17:57,942,124...57,975,149
Ensembl chr17:57,942,162...57,975,654 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of PPARA mRNA CTD PMID:37005939 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PPARGC1A mRNA CTD PMID:37005939 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prss21 serine protease 21 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of PRSS21 mRNA CTD PMID:20816883 NCBI chr10:12,899,820...12,905,612
Ensembl chr10:12,900,535...12,905,618 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:11159734 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD PMID:11159734 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rab7b Rab7b, member RAS oncogene family increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RAB7B mRNA CTD PMID:20816883 NCBI chr13:43,121,168...43,147,581
Ensembl chr13:43,121,226...43,147,581 		JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD18 mRNA CTD PMID:23681119 NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069 		JBrowse link
G Rad23b RAD23 homolog B, nucleotide excision repair protein decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RAD23B mRNA CTD PMID:20816883 NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of RAD51 mRNA CTD PMID:23681119 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RAD51AP1 mRNA CTD PMID:20816883 NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524 		JBrowse link
G Rad54l RAD54 like increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RAD54L mRNA CTD PMID:20816883 NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RAPGEF1 mRNA CTD PMID:20816883 NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984 		JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RBBP6 mRNA CTD PMID:20816883 NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678 		JBrowse link
G Rnf125 ring finger protein 125 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RNF125 mRNA CTD PMID:20816883 NCBI chr18:12,254,066...12,275,719
Ensembl chr18:12,253,852...12,275,983 		JBrowse link
G Rnf186 ring finger protein 186 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of RNF186 mRNA CTD PMID:20816883 NCBI chr 5:151,210,492...151,211,716
Ensembl chr 5:151,210,492...151,211,716 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RPS6KA5 mRNA CTD PMID:20816883 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RRM2 mRNA CTD PMID:20816883 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G S100a2 S100 calcium binding protein A2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of S100A2 mRNA CTD PMID:20816883 NCBI chr 2:176,077,081...176,078,325 JBrowse link
G Serpini2 serpin family I member 2 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SERPINI2 mRNA CTD PMID:20816883 NCBI chr 2:160,014,721...160,044,271
Ensembl chr 2:160,014,721...160,044,280 		JBrowse link
G Shcbp1 SHC binding and spindle associated 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of SHCBP1 mRNA CTD PMID:20816883 NCBI chr16:84,672,277...84,703,843
Ensembl chr16:84,672,321...84,703,844 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SLC15A1 mRNA CTD PMID:20816883 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity		 ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased activity of SLC22A2 protein		 CTD PMID:30189235 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
decreases activity		 ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased activity of SLC22A3 protein		 CTD PMID:30189235 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of SLC7A11 mRNA CTD PMID:20816883 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Smyd3 SET and MYND domain containing 3 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SMYD3 mRNA CTD PMID:22100608 NCBI chr13:90,709,263...91,266,209
Ensembl chr13:90,709,270...91,266,253 		JBrowse link
G Tas2r120 taste receptor, type 2, member 120 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of TAS2R20 mRNA CTD PMID:20816883 NCBI chr 4:165,952,266...165,953,153
Ensembl chr 4:165,952,266...165,953,153 		JBrowse link
G Tbc1d25 TBC1 domain family, member 25 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TBC1D25 mRNA CTD PMID:20816883 NCBI chr  X:14,314,095...14,339,171
Ensembl chr  X:14,314,414...14,338,275 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of TNF mRNA CTD PMID:23681119 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TNFSF9 mRNA CTD PMID:20816883 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
G Top2a DNA topoisomerase II alpha increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TOP2A mRNA CTD PMID:20816883 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 increases mutagenesis
increases expression		 EXP
ISO		 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased mutagenesis of TP53 gene
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TP53 protein		 CTD PMID:8844820 PMID:23810796 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trappc9 trafficking protein particle complex subunit 9 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of TRAPPC9 mRNA CTD PMID:22100608 NCBI chr 7:104,521,593...104,998,352
Ensembl chr 7:104,521,593...104,998,352 		JBrowse link
G Trim63 tripartite motif containing 63 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TRIM63 mRNA CTD PMID:20816883 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322 		JBrowse link
G Trim72 tripartite motif containing 72 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of TRIM72 mRNA CTD PMID:20816883 NCBI chr 1:182,613,753...182,621,613
Ensembl chr 1:182,613,712...182,621,606 		JBrowse link
G Ube2j2 ubiquitin-conjugating enzyme E2, J2 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of UBE2J2 mRNA CTD PMID:20816883 NCBI chr 5:166,533,374...166,547,811
Ensembl chr 5:166,533,418...166,547,804 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of UGT1A1 mRNA CTD PMID:22138251 PMID:23810796 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of UGT1A2 mRNA CTD PMID:22138251 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 multiple interactions ISO [flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in decreased expression of UGT2B1 mRNA CTD PMID:23681119 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of UHRF1 mRNA CTD PMID:20816883 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631 		JBrowse link
G Vamp1 vesicle-associated membrane protein 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of VAMP1 mRNA CTD PMID:20816883 NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349 		JBrowse link
G Vil1 villin 1 decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of VIL1 mRNA CTD PMID:20816883 NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858 		JBrowse link
G Wasl WASP like actin nucleation promoting factor increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of WASL mRNA CTD PMID:20816883 NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator decreases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of YAP1 mRNA CTD PMID:20816883 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
G Zfp799 zinc finger protein 799 increases expression ISO 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ZNF799 mRNA CTD PMID:20816883 NCBI chr 7:11,894,224...11,910,809
Ensembl chr 7:11,898,149...11,910,798 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          nitrogen atom 18979
            nitrogen molecular entity 18979
              organonitrogen compound 18833
                organonitrogen heterocyclic compound 18153
                  imidazoquinoxaline 174
                    MeIQx + 174
                    N-hydroxy-MeIQx 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterotricyclic compound 15845
                                      imidazoquinoxaline 174
                                        MeIQx + 174
                                        N-hydroxy-MeIQx 0
paths to the root