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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:norwogonin
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Accession:CHEBI:7642 term browser browse the term
Definition:A trihydroxyflavone with the hydroxy groups at positions C-5, -7 and -8.
Synonyms:exact_synonym: 5,7,8-trihydroxy-2-phenyl-4H-chromen-4-one
 related_synonym: 2-Phenyl-5,7,8-trihydroxy-4H-1-benzopyran-4-one;   5,7,8-Trihydroxyflavone;   Formula=C15H10O5;   InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H;   InChIKey=ZFKKRRMUPBBYRS-UHFFFAOYSA-N;   SMILES=Oc1cc(O)c2c(oc(cc2=O)-c2ccccc2)c1O
 xref: CAS:4443-09-8;   KEGG:C10113;   KNApSAcK:C00001077;   LIPID_MAPS_instance:LMPK12111329
 xref_mesh: MESH:C055505
 xref: PMID:12494330;   PMID:15563763;   PMID:17252377;   PMID:3281825;   PMID:8117326;   Reaxys:272168


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norwogonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO norwogonin analog results in increased expression of ADIPOQ protein; norwogonin results in increased expression of ADIPOQ protein CTD PMID:30445784 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		EXP
ISO 		norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of BAX mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]
norwogonin results in increased expression of BAX protein 		CTD PMID:32862589 PMID:33413359 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		EXP
ISO 		norwogonin inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]
norwogonin results in decreased expression of BCL2 protein 		CTD PMID:32862589 PMID:33413359 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP norwogonin inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of CASP3 mRNA] CTD PMID:33413359 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase multiple interactions EXP norwogonin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein] CTD PMID:33413359 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO norwogonin results in decreased expression of CCNB1 protein CTD PMID:32862589 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO norwogonin analog results in increased expression of CEBPA protein; norwogonin results in increased expression of CEBPA protein CTD PMID:30445784 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of CYCS mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein] CTD PMID:33413359 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO norwogonin results in increased expression of CYP1A1 protein CTD PMID:37515497 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] CTD PMID:33413359 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Ins1 insulin 1 increases secretion EXP norwogonin analog results in increased secretion of INS1 protein CTD PMID:30445784 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Ins2 insulin 2 increases response to substance ISO norwogonin results in increased susceptibility to INS protein CTD PMID:28854906 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Lep leptin decreases expression ISO norwogonin analog results in decreased expression of LEP protein; norwogonin results in decreased expression of LEP protein CTD PMID:30445784 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Rbp4 retinol binding protein 4 decreases expression ISO norwogonin analog results in decreased expression of RBP4 protein; norwogonin results in decreased expression of RBP4 protein CTD PMID:30445784 NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:245,306,349...245,313,898 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO norwogonin analog results in decreased expression of TNF protein; norwogonin results in decreased expression of TNF protein CTD PMID:30445784 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; norwogonin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein] CTD PMID:33413359 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      chemical role 20396
        antioxidant 16464
          norwogonin 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  oxacycle 18300
                                    benzopyran 12186
                                      1-benzopyran 11917
                                        flavonoid 7550
                                          anthoxanthin 4621
                                            flavones 4621
                                              hydroxyflavone 4598
                                                trihydroxyflavone 465
                                                  norwogonin 16
paths to the root