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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxyphenbutazone
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Accession:CHEBI:76258 term browser browse the term
Definition:A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.
Synonyms:related_synonym: 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine;   1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine;   3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene;   4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione;   4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione;   4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine;   Formula=C19H20N2O3;   Hydroxyphenylbutazon;   InChI=1S/C19H20N2O3/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15/h4-8,10-13,17,22H,2-3,9H2,1H3;   InChIKey=HFHZKZSRXITVMK-UHFFFAOYSA-N;   Oxi-fenibutol;   Oxifenylbutazon;   Oxiphenbutazonum;   Oxyphenylbutazone;   SMILES=CCCCC1C(=O)N(N(C1=O)c1ccc(O)cc1)c1ccccc1;   oxifenbutazona;   oxyphenbutazonum;   p-Hydroxyphenylbutazone;   p-Oxyphenylbutazone
 xref: CAS:129-20-4;   DrugBank:DB03585;   Drug_Central:2036;   KEGG:C19494;   KEGG:D08324;   LINCS:LSM-5029
 xref_mesh: MESH:D010113
 xref: PMID:1222682;   PMID:141661;   PMID:14345781;   PMID:18963985;   PMID:19161668;   PMID:20299217;   PMID:21428758;   PMID:23012453;   PMID:23983013;   PMID:2862290;   PMID:380595;   PMID:501546;   PMID:546857;   PMID:6617711;   PMID:6860567;   PMID:6894379;   PMID:7001487;   PMID:7309664;   PMID:7368966;   PMID:766157;   PMID:835859;   Patent:EP642336;   Patent:US2008014272;   Patent:WO2005107748;   Reaxys:307474;   Wikipedia:Oxyphenbutazone


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oxyphenbutazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Oxyphenbutazone inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Oxyphenbutazone results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        antimicrobial agent 18266
          oxyphenbutazone 2
            oxyphenbutazone hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic heterocyclic compound 18870
                                  organic heteromonocyclic compound 17791
                                    diazolidine 1033
                                      pyrazolidines 29
                                        phenylbutazone 21
                                          oxyphenbutazone 2
                                            oxyphenbutazone hydrate 0
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