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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flunixin
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Accession:CHEBI:76138 term browser browse the term
Definition:A pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a 2-methyl-3-(trifluoromethyl)phenylamino group. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine (usually as the meglumine salt) for treatment of horses, cattle and pigs.
Synonyms:exact_synonym: 2-{[2-methyl-3-(trifluoromethyl)phenyl]amino}nicotinic acid
 related_synonym: 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxylic acid;   2-(alpha(3),alpha(3),alpha(3)-trifluoro-2,3-xylidino)nicotinic acid;   Formula=C14H11F3N2O2;   InChI=1S/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21);   InChIKey=NOOCSNJCXJYGPE-UHFFFAOYSA-N;   SMILES=Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F;   Sch 14714;   flunixine;   flunixino;   flunixinum
 xref: CAS:38677-85-9;   KEGG:D04215
 xref_mesh: MESH:C014557
 xref: PMID:26512724;   PMID:26695354;   PMID:27242945;   PMID:27731498;   PMID:27958751;   PMID:2816;   Patent:US2008014272;   Patent:US5637617;   Reaxys:492802;   VSDB:1802;   Wikipedia:Flunixin
 cyclic_relationship: is_conjugate_acid_of CHEBI:76153


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flunixin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity EXP flunixin results in decreased activity of PTGS1 protein CTD PMID:12967936 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          metabolite 19537
            nicotinic acid 275
              flunixin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      monocarboxylic acid 18000
                                        pyridinemonocarboxylic acid 424
                                          nicotinic acid 275
                                            flunixin 1
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