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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:deuterated compound
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Accession:CHEBI:76107 term browser browse the term
Definition:Any isotopically modified compound that has one or more hydrogen atoms replaced by deuterium.
Synonyms:related_synonym: (2)H-labeled compound;   (2)H-labeled compounds;   (2)H-labelled compound;   (2)H-labelled compounds;   deuterated compounds;   deuterium-labeled compound;   deuterium-labeled compounds;   deuterium-labelled compound;   deuterium-labelled compounds


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dideuterium oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO Deuterium Oxide results in decreased phosphorylation of AKT1 protein
Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of AKT1 protein]		 CTD PMID:37751786 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases phosphorylation
multiple interactions		 ISO Deuterium Oxide results in decreased phosphorylation of AKT2 protein
Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of AKT2 protein]		 CTD PMID:37751786 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 decreases phosphorylation
multiple interactions		 ISO Deuterium Oxide results in decreased phosphorylation of AKT3 protein
Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of AKT3 protein]		 CTD PMID:37751786 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Deuterium Oxide results in increased expression of BAX protein CTD PMID:37751786 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 ISO Deuterium Oxide results in increased expression of BECN1 protein
Acetylcysteine inhibits the reaction [Deuterium Oxide results in increased expression of BECN1 protein]		 CTD PMID:37751786 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO Deuterium Oxide results in increased cleavage of CASP3 protein CTD PMID:37751786 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Acetylcysteine inhibits the reaction [Deuterium Oxide results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Deuterium Oxide results in increased expression of and results in increased lipidation of MAP1LC3B protein CTD PMID:37751786 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions		 ISO Deuterium Oxide results in decreased phosphorylation of MTOR protein
Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of MTOR protein]		 CTD PMID:37751786 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of PIK3R1 protein] CTD PMID:37751786 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
Palmitic acid(d3) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO Palmitic acid increases expression of BAX mRNA in cardiomyocytes
ghrelin inhibits the reaction [Palmitic acid increases expression of BAX mRNA in cardiomyocytes]		 RGD PMID:32084395 PMID:32084395 RGD:242905211, RGD:242905211 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Palmitic acid decreases expression of BCL2 mRNA in cardiomyocytes
ghrelin inhibits the reaction [Palmitic acid decreases expression of BCL2 mRNA in cardiomyocytes]		 RGD PMID:32084395 PMID:32084395 RGD:242905211, RGD:242905211 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO Palmitic acid increases expression of IL1b mRNA in cardiomyocytes
ghrelin inhibits the reaction [Palmitic acid increases expression of IL1b mRNA in cardiomyocytes]		 RGD PMID:32084395 PMID:32084395 RGD:242905211, RGD:242905211 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Palmitic acid increases expression of IL6 mRNA in cardiomyocytes
ghrelin inhibits the reaction [Palmitic acid increases expression of IL6 mRNA in cardiomyocytes]		 RGD PMID:32084395 PMID:32084395 RGD:242905211, RGD:242905211 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions		 ISO Palmitic acid increases expression of IL1b mRNA in cardiomyocytes
ghrelin inhibits the reaction [Palmitic acid increases expression of TGFB1 mRNA in cardiomyocytes] 		RGD PMID:32084395 PMID:32084395 RGD:242905211, RGD:242905211 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		ISO ghrelin inhibits the reaction [Palmitic acid increases expression of TNF mRNA in cardiomyocytes] RGD PMID:32084395 PMID:32084395 RGD:242905211, RGD:242905211 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      molecular entity 19872
        isotopically modified compound 15
          deuterated compound 14
            1,1,2,2-tetrachlorethane-d2 0
            1,2-dimyristoyl-d54-sn-glycero-3-phosphocholine 0
            1-(methyl-d3)-2-pyridoxone-5-carboxamide 0
            1-methyl nicotinamide-d3 0
            1-methyl-4-pyridone-5-carboxamide-d2 0
            2,2,2-trideuterio-N-[1,1,2,2-tetradeuterio-2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide 0
            2-oxobutyric acid-(13)C4,3,3-d2 0
            3-(trimethylsilyl)-1-propanesulfonic acid-d6 0
            3-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-1,2-dipalmitoyl-16,16,16-d3-sn-glycerol 0
            Caffeine-D3 0
            Creatine D3 0
            D-valine-d8 0
            L-Alanine-d3 0
            L-alanine-2,3,3,3-d4 0
            L-arginine-d7 0
            L-aspartic acid-d7 0
            L-carnitine-d9 0
            L-citrulline-d2 0
            L-glutamic acid-d5 0
            L-leucine-d10 0
            L-leucine-d3 0
            L-methionine-d3 0
            L-ornithine-d6 0
            L-phenylalanine-d5 0
            L-proline-d7 0
            L-tyrosine-d4 0
            L-valine-d8 0
            LSD-d3 0
            N,N-dimethylformamide-d7 0
            Phenobarbital-d5 0
            acetic acid-d4 0
            acetone d6 0
            acetonitrile-d3 0
            acetyl-L-carnitine-d3 0
            alanine-2,3,3,3-d4 0
            alanine-d7 0
            alpha-muricholic acid-d5 0
            amitriptyline-d3 0
            benzene-d6 0
            butyryl-L-carnitine-d3 0
            caffeine-d9 0
            cholesterol-2,2,3,4,4,6-d6 0
            citric acid-d4 0
            d2-biotin 0
            d4-trimethyl silyl propionic acid 0
            decanoyl-L-carnitine-d3 0
            deoxycholic acid-2,2,4,4-d4 0
            deuterated chloroform 0
            deuterated fatty acid + 6
            deuterium hydrogen oxide 0
            diazepam-d8 0
            dichloromethane-d2 0
            dideuterium oxide 9
            dimethyl ether-d6 0
            dimethyl sulfoxide-d6 0
            dodecanoyl-L-carnitine-d3 0
            ethanol-d6 0
            formic acid-d2 0
            gemini-0072 0
            gemini-0097 0
            glutamic acid-2,3,3,4,4-d5 0
            glutaryl-L-carnitine-d6 0
            glycine-d5 0
            glycocholic acid-d4 0
            glycodeoxycholic acid-2,2,4,4-d4 0
            harmine-d3 0
            hexadecenoyl-L-carnitine-d3 0
            leucine-d10 0
            lithocholic acid-2,2,4,4-d4 0
            lysine-4,4,5,5-d4 0
            methanol-d1 0
            methanol-d4 0
            nicotinic-d4 acid 0
            nitrobenzene-d5 0
            nitromethane-d3 0
            octanoyl-L-carnitine-d3 0
            oxolane-d8 0
            phenylalanine-d5 0
            propionyl-L-carnitine-d3 0
            pyridine-d5 0
            succinic acid-d4 0
            taurochenodeoxycholic acid-2,2,4,4-d4 0
            taurodeoxycholic acid-d4 0
            tetradecanoyl-L-carnitine-d3 0
            tetramethylsilane-d12 0
            toluene-d8 0
            trifluoroacetic acid-d1 0
            tryptophan-2,3,3-d3 0
            valeryl-L-carnitine-d9 0
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