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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vortioxetine
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Accession:CHEBI:76016 term browser browse the term
Definition:An N-arylpiperazine in which the aryl group is specified as 2-[(2,4-dimethylphenyl)sulfanyl]phenyl. Used (as its hydrobromide salt) for treatment of major depressive disorder.
Synonyms:exact_synonym: 1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine
 related_synonym: Formula=C18H22N2S;   Lu AA21004;   vortioxetina;   vortioxetinum
 xref: CAS:508233-74-7;   Drug_Central:4806;   KEGG:D10184
 xref_mesh: MESH:C557874
 xref: PMID:21767441;   PMID:22171087;   PMID:22209361;   PMID:22448783;   PMID:22475889;   PMID:22495621;   PMID:22496396;   PMID:22572889;   PMID:22612991;   PMID:22898365;   PMID:22901346;   PMID:22901736;   PMID:22963932;   PMID:22978748;   PMID:23089374;   PMID:23252878;   PMID:23380522;   PMID:23428337;   PMID:23531115;   PMID:23588319;   PMID:23721744;   PMID:23903233;   PMID:23916504;   PMID:23975654;   PMID:24016840;   Patent:WO2008113359;   Reaxys:11341374;   Wikipedia:Vortioxetine
 cyclic_relationship: is_conjugate_base_of CHEBI:76017


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vortioxetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 affects binding ISO vortioxetine binds to ADRB1 protein CTD PMID:21486038 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Cdh1 cadherin 1 decreases expression ISO Vortioxetine results in decreased expression of CDH1 protein CTD PMID:38043629 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO vortioxetine binds to and results in increased activity of HTR1A protein CTD PMID:21486038 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions ISO vortioxetine binds to and affects the activity of HTR1B protein CTD PMID:21486038 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions ISO
EXP		 Ondansetron affects the reaction [vortioxetine binds to and affects the activity of HTR3A protein]; vortioxetine binds to and affects the activity of HTR3A protein
vortioxetine binds to and results in decreased activity of HTR3A protein		 CTD PMID:21486038 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO vortioxetine binds to and results in decreased activity of HTR7 protein CTD PMID:21486038 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
decreases expression		 ISO
EXP		 vortioxetine binds to and results in decreased activity of SLC6A4 protein
Vortioxetine results in decreased expression of SLC6A4 protein		 CTD PMID:21486038 PMID:38043629 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO Vortioxetine results in decreased expression of TJP1 protein CTD PMID:38043629 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      biological role 19868
        pharmacological role 19105
          neurotransmitter agent 16812
            serotonergic drug 4389
              serotonergic agonist 1023
                vortioxetine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    main group molecular entity 19836
                      s-block molecular entity 19670
                        hydrogen molecular entity 19652
                          hydrides 19162
                            inorganic hydride 18180
                              pnictogen hydride 18170
                                nitrogen hydride 18083
                                  azane 17891
                                    ammonia 17890
                                      organic amino compound 17890
                                        tertiary amino compound 10170
                                          N-arylpiperazine 3439
                                            vortioxetine 8
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