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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amfenac
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Accession:CHEBI:75915 term browser browse the term
Definition:An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery.
Synonyms:exact_synonym: (2-amino-3-benzoylphenyl)acetic acid
 related_synonym: (2-Amino-3-benzoylphenyl)essigsaeure;   2-amino-3-benzoylbenzeneacetic acid;   Formula=C15H13NO3;   InChI=1S/C15H13NO3/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10/h1-8H,9,16H2,(H,17,18);   InChIKey=SOYCMDCMZDHQFP-UHFFFAOYSA-N;   SMILES=Nc1c(CC(O)=O)cccc1C(=O)c1ccccc1;   amfenaco;   amfenacum
 xref: CAS:51579-82-9;   Drug_Central:154;   KEGG:D07443;   PMID:10850857;   PMID:19897019;   PMID:3540874;   PMID:8320556;   Patent:DE2324768;   Patent:US4045576;   Reaxys:2381781;   Wikipedia:Amfenac
 cyclic_relationship: is_conjugate_acid_of CHEBI:75917


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bromfenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO bromfenac results in decreased activity of ABCB11 protein CTD PMID:22646477 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO bromfenac results in decreased activity of ABCC2 protein CTD PMID:22646477 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO bromfenac results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of bromfenac metabolite CTD PMID:31815452 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases hydroxylation ISO CYP2C19 protein results in increased hydroxylation of bromfenac CTD PMID:31815452 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of bromfenac CTD PMID:31815452
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of bromfenac metabolite CTD PMID:31815452 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ereg epiregulin increases expression ISO bromfenac results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO bromfenac results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO bromfenac results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO bromfenac results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO bromfenac results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO bromfenac results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO bromfenac results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases metabolic processing
multiple interactions		 ISO UGT2B7 protein results in increased metabolism of bromfenac
Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased metabolism of bromfenac]		 CTD PMID:31815452 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        anti-inflammatory agent 16672
          anti-inflammatory drug 14964
            non-steroidal anti-inflammatory drug 14280
              amfenac 15
                bromfenac 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        aromatic amine 15483
                                          anilines 14421
                                            substituted aniline 14051
                                              amfenac 15
                                                bromfenac 15
paths to the root