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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hispidulin
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Accession:CHEBI:75902 term browser browse the term
Definition:A monomethoxyflavone that is scutellarein methylated at position 6.
Synonyms:exact_synonym: 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one
 related_synonym: 4',5,7-Trihydroxy-6-methoxyflavone;   Dinatin;   Formula=C16H12O6;   InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3;   InChIKey=IHFBPDAQLQOCBX-UHFFFAOYSA-N;   NSC 122415;   SMILES=COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)cc1;   Scutellarein 6-methyl ether
 alt_id: CHEBI:5732
 xref: CAS:1447-88-7;   KEGG:C10058;   KNApSAcK:C00001050;   LIPID_MAPS_instance:LMPK12111159
 xref_mesh: MESH:C055957
 xref: PMID:11585687;   PMID:20117183;   PMID:20698539;   PMID:20734985;   PMID:20738216;   PMID:21087351;   PMID:21162116;   PMID:21329950;   PMID:21552369;   PMID:22418930;   PMID:22674731;   PMID:22759588;   PMID:22978216;   PMID:23189738;   PMID:23791609;   PMID:24009700;   PMID:24068521;   Reaxys:1293933;   Wikipedia:Hispidulin



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hispidulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] CTD PMID:30055130 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] CTD PMID:30055130 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cxcl17 C-X-C motif chemokine ligand 17 multiple interactions ISO hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CXCL17 mRNA] CTD PMID:32679548 NCBI chr 1:80,984,751...80,996,842
Ensembl chr 1:80,984,964...80,996,726
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO hispidulin inhibits the reaction [Imiquimod results in increased expression of CXCL1 mRNA] CTD PMID:32679548 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Ifng interferon gamma multiple interactions ISO hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CXCL17 mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL18BP mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL1B mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of TNF mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein] CTD PMID:32679548 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il17a interleukin 17A multiple interactions ISO hispidulin inhibits the reaction [Imiquimod results in increased expression of IL17A mRNA] CTD PMID:32679548 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18bp interleukin 18 binding protein multiple interactions ISO hispidulin inhibits the reaction [Imiquimod results in increased expression of IL18BP mRNA]
hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL18BP mRNA]
CTD PMID:32679548 NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO hispidulin inhibits the reaction [Imiquimod results in increased expression of IL1B mRNA]
hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL1B mRNA]
CTD PMID:32679548 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 multiple interactions ISO hispidulin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 mRNA] CTD PMID:31195760 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO hispidulin inhibits the reaction [Imiquimod results in increased expression of IL6 mRNA] CTD PMID:32679548 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO hispidulin decreases phoshphorylation of JAK2 protein in colon and colorectum RGD PMID:29575334 RGD:149735333 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]
hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
CTD PMID:22759588 PMID:32679548 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]
hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
CTD PMID:22759588 PMID:32679548 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein] CTD PMID:32679548 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO hispidulin inhibits the reaction [Imiquimod results in increased expression of MPO protein] CTD PMID:32679548 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein] CTD PMID:32679548 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO hispidulin inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose] CTD PMID:36870413 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 decreases activity
multiple interactions
EXP hispidulin results in decreased activity of SLCO1B1 protein
[hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate
CTD PMID:32259555 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289
JBrowse link
G Syn1 synapsin I affects response to substance ISO SYN1 protein affects the susceptibility to hispidulin CTD PMID:22759588 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO hispidulin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CXCL17 mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL18BP mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of IL1B mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of TNF mRNA]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]; hispidulin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]
hispidulin inhibits the reaction [Imiquimod results in increased expression of TNF protein]
CTD PMID:31195760 PMID:32679548 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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  CHEBI ontology 19874
    role 19844
      chemical role 19473
        antioxidant 16145
          hispidulin 22
Path 2
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  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  oxacycle 17903
                                    benzopyran 11971
                                      1-benzopyran 11725
                                        flavonoid 7225
                                          anthoxanthin 4584
                                            flavones 4584
                                              hydroxyflavone 4561
                                                trihydroxyflavone 453
                                                  apigenin 306
                                                    scutellarein 71
                                                      hispidulin 22
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