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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-pyranones
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Accession:CHEBI:75885 term browser browse the term
Definition:A pyranone based on the structure of 2H-pyran-2-one and its substituted derivatives.
Synonyms:related_synonym: 2-oxo-2H-pyrans;   2-pyrones;   2H-pyran-2-ones;   alpha-pyrones;   pyran-2-ones


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5,6-Dehydrokawain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 5,6-dehydrokawain results in increased expression of CYP1A1 mRNA CTD PMID:21908763 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
Citreoviridin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation 		EXP
ISO 		Rosiglitazone inhibits the reaction [citreoviridin results in decreased phosphorylation of AKT1 protein]; Sodium Selenite inhibits the reaction [citreoviridin results in decreased phosphorylation of AKT1 protein]; Thiamine inhibits the reaction [citreoviridin results in decreased phosphorylation of AKT1 protein] CTD PMID:31419397 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Aqp7 aquaporin 7 multiple interactions
decreases expression 		EXP
ISO 		Sodium Selenite inhibits the reaction [citreoviridin results in decreased expression of AQP7 mRNA]; Thiamine inhibits the reaction [citreoviridin results in decreased expression of AQP7 mRNA] CTD PMID:31419397 NCBI chr 5:60,968,495...60,982,618
Ensembl chr 5:60,967,558...60,982,618 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression ISO citreoviridin results in increased expression of ARC mRNA CTD PMID:30071239 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions 		ISO
EXP 		citreoviridin results in increased expression of BAX protein
3-methyladenine inhibits the reaction [citreoviridin results in increased expression of BAX protein]; Rosiglitazone inhibits the reaction [citreoviridin results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [citreoviridin results in increased expression of BAX protein]; Thiamine inhibits the reaction [citreoviridin results in increased expression of BAX protein] 		CTD PMID:31419397 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		EXP
ISO 		citreoviridin results in decreased expression of BCL2 protein
Sodium Selenite inhibits the reaction [citreoviridin results in decreased expression of BCL2 protein]; Thiamine inhibits the reaction [citreoviridin results in decreased expression of BCL2 protein]
3-methyladenine inhibits the reaction [citreoviridin results in decreased expression of BCL2 protein]; Rosiglitazone inhibits the reaction [citreoviridin results in decreased expression of BCL2 protein]; Sodium Selenite inhibits the reaction [citreoviridin results in decreased expression of BCL2 protein]; Thiamine inhibits the reaction [citreoviridin results in decreased expression of BCL2 protein] 		CTD PMID:31419397 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bdnf brain-derived neurotrophic factor affects expression ISO citreoviridin affects the expression of BDNF mRNA CTD PMID:30071239 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects expression ISO citreoviridin affects the expression of CHRNA4 mRNA CTD PMID:30071239 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit decreases expression ISO citreoviridin results in decreased expression of CHRNA7 mRNA CTD PMID:30071239 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit increases expression ISO citreoviridin results in increased expression of CHRNB2 mRNA CTD PMID:30071239 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326 		JBrowse link
G Ckb creatine kinase B multiple interactions ISO
EXP 		citreoviridin results in increased secretion of [CKM protein binds to CKB protein]; Sodium Selenite inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]; Thiamine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]
3-methyladenine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]; citreoviridin results in increased secretion of [CKM protein binds to CKB protein]; Rosiglitazone inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]; Sodium Selenite inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]; Thiamine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]] 		CTD PMID:31419397 NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP
ISO 		3-methyladenine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]; citreoviridin results in increased secretion of [CKM protein binds to CKB protein]; Rosiglitazone inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]; Sodium Selenite inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]; Thiamine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]
citreoviridin results in increased secretion of [CKM protein binds to CKB protein]; Sodium Selenite inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]; Thiamine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]] 		CTD PMID:31419397 NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719 		JBrowse link
G Dcx doublecortin affects expression ISO citreoviridin affects the expression of DCX mRNA CTD PMID:30071239 NCBI chr  X:112,227,455...112,370,291
Ensembl chr  X:112,227,455...112,304,161 		JBrowse link
G Eomes eomesodermin increases expression ISO citreoviridin results in increased expression of EOMES mRNA CTD PMID:30071239 NCBI chr 8:127,059,215...127,067,070
Ensembl chr 8:127,059,215...127,067,070 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
decreases expression 		EXP
ISO 		Sodium Selenite inhibits the reaction [citreoviridin results in decreased expression of FABP4 mRNA]; Thiamine inhibits the reaction [citreoviridin results in decreased expression of FABP4 mRNA] CTD PMID:31419397 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fgf21 fibroblast growth factor 21 decreases expression ISO citreoviridin results in decreased expression of FGF21 mRNA CTD PMID:28645467 NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:105,219,825...105,232,056 		JBrowse link
G Gfap glial fibrillary acidic protein affects expression ISO citreoviridin affects the expression of GFAP mRNA CTD PMID:30071239 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 decreases expression ISO citreoviridin results in decreased expression of GRIA1 mRNA CTD PMID:30071239 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 affects expression ISO citreoviridin affects the expression of GRIA2 mRNA CTD PMID:30071239 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression ISO citreoviridin results in increased expression of GRIA3 mRNA CTD PMID:30071239 NCBI chr  X:125,103,975...125,369,690
Ensembl chr  X:125,103,782...125,369,679 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D decreases expression ISO citreoviridin results in decreased expression of GRIN2D mRNA CTD PMID:30071239 NCBI chr 1:105,443,317...105,483,400
Ensembl chr 1:105,444,813...105,481,236 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression 		ISO
EXP 		Sodium Selenite inhibits the reaction [citreoviridin results in increased expression of MAP1LC3B protein modified form]; Thiamine inhibits the reaction [citreoviridin results in increased expression of MAP1LC3B protein modified form]
Rosiglitazone inhibits the reaction [citreoviridin results in increased expression of MAP1LC3B protein modified form]; Sodium Selenite inhibits the reaction [citreoviridin results in increased expression of MAP1LC3B protein modified form]; Thiamine inhibits the reaction [citreoviridin results in increased expression of MAP1LC3B protein modified form] 		CTD PMID:31419397 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Neurod1 neuronal differentiation 1 affects expression ISO citreoviridin affects the expression of NEUROD1 mRNA CTD PMID:30071239 NCBI chr 3:84,766,483...84,770,454
Ensembl chr 3:84,764,725...84,770,810 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression ISO citreoviridin results in increased expression of NTRK2 mRNA CTD PMID:30071239 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases activity 		EXP Sodium Selenite inhibits the reaction [citreoviridin results in decreased activity of PPARG protein]; Thiamine inhibits the reaction [citreoviridin results in decreased activity of PPARG protein] CTD PMID:31419397 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Pvalb parvalbumin increases expression ISO citreoviridin results in increased expression of PVALB mRNA CTD PMID:30071239 NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:111,653,111...111,668,446 		JBrowse link
G Slc17a6 solute carrier family 17 member 6 decreases expression ISO citreoviridin results in decreased expression of SLC17A6 mRNA CTD PMID:30071239 NCBI chr 1:110,348,447...110,388,499
Ensembl chr 1:110,348,447...110,388,498 		JBrowse link
G Slc17a7 solute carrier family 17 member 7 affects expression ISO citreoviridin affects the expression of SLC17A7 mRNA CTD PMID:30071239 NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:104,785,955...104,798,049 		JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO citreoviridin results in increased expression of SOX2 mRNA CTD PMID:30071239 NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression 		ISO
EXP 		Sodium Selenite inhibits the reaction [citreoviridin results in decreased expression of SQSTM1 protein]; Thiamine inhibits the reaction [citreoviridin results in decreased expression of SQSTM1 protein]
Rosiglitazone inhibits the reaction [citreoviridin results in decreased expression of SQSTM1 protein]; Sodium Selenite inhibits the reaction [citreoviridin results in decreased expression of SQSTM1 protein]; Thiamine inhibits the reaction [citreoviridin results in decreased expression of SQSTM1 protein] 		CTD PMID:31419397 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Sst somatostatin increases expression ISO citreoviridin results in increased expression of SST mRNA CTD PMID:30071239 NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions
increases secretion 		EXP
ISO 		3-methyladenine inhibits the reaction [citreoviridin results in increased secretion of TNNT2 protein]; Rosiglitazone inhibits the reaction [citreoviridin results in increased secretion of TNNT2 protein]; Sodium Selenite inhibits the reaction [citreoviridin results in increased secretion of TNNT2 protein]; Thiamine inhibits the reaction [citreoviridin results in increased secretion of TNNT2 protein] CTD PMID:31419397 NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125 		JBrowse link
G Vnn1 vanin 1 decreases expression ISO citreoviridin results in decreased expression of VNN1 mRNA CTD PMID:28645467 NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:23,356,330...23,366,629 		JBrowse link
Dihydrokavain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D decreases activity
multiple interactions 		ISO dihydrokavain results in decreased activity of CES1 protein
dihydrokavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate] 		CTD PMID:35278473 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
fostriecin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased expression of BBC3 protein]] CTD PMID:24954032 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]] CTD PMID:24954032 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]] CTD PMID:24954032 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO fostriecin promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]] CTD PMID:24954032 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
hispidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp9 caspase 9 multiple interactions
increases activity 		EXP hispidin inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]
hispidin results in increased activity of CASP9 protein 		CTD PMID:26318906 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP hispidin inhibits the reaction [Doxorubicin results in increased expression of and results in decreased phosphorylation of and affects the localization of SHC1 protein] CTD PMID:26318906 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO hispidin inhibits the reaction [Cyclosporine results in increased phosphorylation of and results in increased activity of SMAD2 protein] CTD PMID:22155090 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
Methysticin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [methysticin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; AHR protein affects the susceptibility to [methysticin results in increased activity of CYP1A1 protein]; AHR protein affects the susceptibility to [methysticin results in increased expression of CYP1A1 mRNA] CTD PMID:21908763 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein]; methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity
multiple interactions 		ISO methysticin results in decreased activity of CES1 protein
methysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate] 		CTD PMID:35278473 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression 		ISO 3',4'-dimethoxyflavone inhibits the reaction [methysticin results in increased activity of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [methysticin results in increased expression of CYP1A1 mRNA]; [methysticin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; AHR protein affects the susceptibility to [methysticin results in increased activity of CYP1A1 protein]; AHR protein affects the susceptibility to [methysticin results in increased expression of CYP1A1 mRNA]; methysticin results in increased expression of and results in increased activity of CYP1A1 protein CTD PMID:21908763 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity EXP methysticin results in decreased activity of CYP2C19 protein CTD PMID:16033948 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 decreases activity EXP methysticin results in decreased activity of CYP2C9 protein CTD PMID:16033948 NCBI chr 1:247,966,295...248,022,393
Ensembl chr 1:247,966,346...248,022,388 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO methysticin results in increased expression of GCLC mRNA CTD PMID:28448946 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO methysticin results in increased expression of HMOX1 mRNA CTD PMID:28448946 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein] CTD PMID:28448946 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO methysticin affects the localization of NFE2L2 protein CTD PMID:28448946 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein]; methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
mevalonolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO mevalonolactone results in decreased activity of HMGCR protein CTD PMID:3042028 PMID:12477733 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Ptgir prostaglandin I2 receptor affects binding ISO mevalonolactone binds to PTGIR protein CTD PMID:11895442 NCBI chr 1:86,707,690...86,710,073
Ensembl chr 1:86,707,503...86,711,874 		JBrowse link
G Rap2a RAP2A, member of RAS oncogene family increases farnesylation ISO mevalonolactone results in increased farnesylation of RAP2A protein CTD PMID:8424780 NCBI chr15:104,003,744...104,004,234 JBrowse link
G Rap2b RAP2B, member of RAS oncogene family increases prenylation ISO mevalonolactone results in increased prenylation of RAP2B protein CTD PMID:8424780 NCBI chr 2:147,749,387...147,749,938
Ensembl chr 2:147,748,791...147,755,549 		JBrowse link
mevastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aacs acetoacetyl-CoA synthetase multiple interactions EXP [Cholestyramine Resin co-treated with mevastatin] results in increased expression of and results in increased activity of AACS protein; mevastatin results in increased expression of and results in increased activity of AACS protein CTD PMID:3082367 NCBI chr12:36,774,471...36,817,835
Ensembl chr12:36,774,471...36,822,543 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 affects expression
decreases expression
multiple interactions 		EXP
ISO 		mevastatin affects the expression of ABCA1 mRNA
Mevastatin (compactin) decreases expression of abca1 mRNA in rat peripheral fibroblasts
Mevalonic Acid inhibits the reaction [mevastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]] 		CTD
RGD		 PMID:16415093 PMID:17526932 PMID:17526932 RGD:2308820 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO mevastatin inhibits the reaction [BDNF protein results in decreased activity of HU 211] CTD PMID:20554863 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO mevastatin results in increased expression of BMP2 mRNA; mevastatin results in increased expression of BMP2 protein CTD PMID:10814523 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO CYBB protein affects the reaction [mevastatin results in increased expression of HMOX1 protein] CTD PMID:39431643 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression 		ISO [mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA] CTD PMID:12235278 PMID:15466163 PMID:17041008 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases expression 		ISO EIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA] CTD PMID:16330322 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO mevastatin results in increased phosphorylation of EIF2AK3 protein CTD PMID:16330322 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO EIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA] CTD PMID:16330322 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649 		JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation
multiple interactions
increases phosphorylation 		ISO mevastatin results in decreased phosphorylation of FOXO1 protein
5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid inhibits the reaction [mevastatin results in increased phosphorylation of FOXO1 protein]; FOXO1 protein affects the reaction [mevastatin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [mevastatin results in increased phosphorylation of FOXO1 protein] 		CTD PMID:33034787 PMID:39431643 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions 		ISO mevastatin results in increased expression of HMOX1 mRNA; mevastatin results in increased expression of HMOX1 protein
5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid inhibits the reaction [mevastatin results in increased expression of HMOX1 mRNA]; 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid inhibits the reaction [mevastatin results in increased expression of HMOX1 protein]; acetovanillone inhibits the reaction [mevastatin results in increased expression of HMOX1 protein]; CYBB protein affects the reaction [mevastatin results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [mevastatin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [mevastatin results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [mevastatin results in increased expression of HMOX1 protein]; diphenyleneiodonium inhibits the reaction [mevastatin results in increased expression of HMOX1 protein]; FOXO1 protein affects the reaction [mevastatin results in increased expression of HMOX1 protein]; KEAP1 protein affects the reaction [mevastatin results in increased expression of HMOX1 mRNA]; KEAP1 protein affects the reaction [mevastatin results in increased expression of HMOX1 protein]; MAPK14 protein affects the reaction [mevastatin results in increased expression of HMOX1 protein]; MAPK8 protein affects the reaction [mevastatin results in increased expression of HMOX1 protein]; mevastatin promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; NCF1 protein affects the reaction [mevastatin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [mevastatin results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [mevastatin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [mevastatin results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [mevastatin results in increased expression of HMOX1 protein] 		CTD PMID:39431643 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 multiple interactions
increases expression 		ISO EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA] CTD PMID:16330322 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524 		JBrowse link
G Ifng interferon gamma multiple interactions ISO mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO mevastatin promotes the reaction [IL1B protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression ISO mevastatin results in decreased expression of IRF4 protein CTD PMID:33034787 NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,930,471...33,948,730 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO KEAP1 protein affects the reaction [mevastatin results in increased expression of HMOX1 mRNA]; KEAP1 protein affects the reaction [mevastatin results in increased expression of HMOX1 protein] CTD PMID:39431643 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein affects the reaction [mevastatin results in increased expression of HMOX1 protein] CTD PMID:39431643 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation 		ISO Acetylcysteine inhibits the reaction [mevastatin results in increased phosphorylation of MAPK8 protein]; Edaravone inhibits the reaction [mevastatin results in increased phosphorylation of MAPK8 protein]; MAPK8 protein affects the reaction [mevastatin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [mevastatin results in increased phosphorylation of MAPK8 protein] CTD PMID:39431643 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions 		ISO mevastatin results in increased phosphorylation of MAPK9 protein
Acetylcysteine inhibits the reaction [mevastatin results in increased phosphorylation of MAPK9 protein]; Edaravone inhibits the reaction [mevastatin results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [mevastatin results in increased phosphorylation of MAPK9 protein] 		CTD PMID:39431643 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression
multiple interactions 		ISO mevastatin results in increased expression of MSMO1 mRNA
EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA] 		CTD PMID:16330322 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Mstn myostatin increases expression ISO mevastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:55,944,513...55,950,913
Ensembl chr 9:55,944,513...55,950,913 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases phosphorylation
multiple interactions 		ISO mevastatin results in increased phosphorylation of NCF1 protein
acetovanillone inhibits the reaction [mevastatin results in increased phosphorylation of NCF1 protein]; diphenyleneiodonium inhibits the reaction [mevastatin results in increased phosphorylation of NCF1 protein]; NCF1 protein affects the reaction [mevastatin results in increased expression of HMOX1 protein] 		CTD PMID:39431643 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases phosphorylation 		ISO mevastatin promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; NFE2L2 protein affects the reaction [mevastatin results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [mevastatin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [mevastatin results in increased phosphorylation of NFE2L2 protein] CTD PMID:39431643 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Mevastatin increases expression of NR1H3 mRNA in mononuclear cells RGD PMID:16252156 RGD:401827902 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA] CTD PMID:12235278 PMID:17041008 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO mevastatin results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein] CTD PMID:16734383 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO mevastatin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] CTD PMID:39431643 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rhoa ras homolog family member A decreases lipidation
multiple interactions 		ISO mevastatin results in decreased lipidation of RHOA protein
Mevalonic Acid inhibits the reaction [mevastatin results in decreased lipidation of RHOA protein] 		CTD PMID:17322126 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Sele selectin E multiple interactions ISO mevastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]; mevastatin promotes the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
increases cleavage
multiple interactions 		EXP
ISO 		mevastatin results in decreased expression of SREBF1 protein
mevastatin results in increased cleavage of SREBF1 protein
EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein] 		CTD PMID:16330322 PMID:17526932 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression
increases cleavage 		EXP
ISO 		mevastatin results in increased expression of SREBF2 protein
mevastatin results in increased cleavage of SREBF2 protein 		CTD PMID:16330322 PMID:17526932 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO mevastatin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; mevastatin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; mevastatin promotes the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:10946302 PMID:39431643 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO mevastatin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:39431643 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Tunicamycin inhibits the reaction [mevastatin results in increased cleavage of XBP1 protein] CTD PMID:16330322 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
Yangonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
increases expression 		ISO NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein]
yangonin results in increased expression of ABCB11 mRNA; yangonin results in increased expression of ABCB11 protein 		CTD PMID:29660435 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein] CTD PMID:29660435 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 protein]]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 mRNA]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCNB1 protein] CTD PMID:29660435 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression 		ISO pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 protein]]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 mRNA]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCND1 protein]
yangonin results in increased expression of CCND1 protein 		CTD PMID:29660435 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity
multiple interactions 		ISO yangonin results in decreased activity of CES1 protein
yangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate] 		CTD PMID:35278473 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO yangonin results in increased expression of CYP1A1 mRNA CTD PMID:21908763 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions 		ISO yangonin results in decreased expression of CYP7A1 mRNA
NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA] 		CTD PMID:29660435 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO yangonin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 mRNA] CTD PMID:29660435 NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689 		JBrowse link
G Foxm1 forkhead box M1 multiple interactions
increases expression 		ISO NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 protein]]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 mRNA]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 protein]
yangonin results in increased expression of FOXM1 protein 		CTD PMID:29660435 NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:163,325,614...163,337,172 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO NR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]]; yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA] CTD PMID:29660435 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA] CTD PMID:29660435 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
affects response to substance
increases expression 		ISO yangonin binds to and results in increased activity of NR1H4 protein
NR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]]; NR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA protein]]; NR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]]; NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]]; NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]; NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein]]; NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of FOXM1 protein]]; yangonin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR1H4 protein]
NR1H4 affects the susceptibility to yangonin
yangonin results in increased expression of NR1H4 mRNA 		CTD PMID:29660435 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO NR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA mRNA]]; yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA mRNA]; yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA protein] CTD PMID:29660435 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO NR1H4 promotes the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]; yangonin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 protein] CTD PMID:29660435 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression
multiple interactions 		ISO yangonin results in increased expression of SULT2A1 mRNA
yangonin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of SULT2A1 mRNA] 		CTD PMID:29660435 NCBI chr 1:84,582,011...84,639,001 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO NR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA]]; yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF mRNA] CTD PMID:29660435 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      group 20774
        inorganic group 20110
          oxo group 18827
            organic oxo compound 18827
              carbonyl compound 18827
                carboxylic ester 17347
                  lactone 13231
                    delta-lactone 3390
                      2-pyranones 97
                        (+)-Dihydrokawain-5-ol 0
                        (+)-cis-5,6-Dihydro-5-hydroxy-4-methoxy-6-(2-phenylethyl)-2H-pyran-2-one 0
                        (+/-)-Dihydromethysticin 0
                        (2R)-4-methoxy-2-(2-phenylethenyl)-2,3-dihydropyran-6-one 0
                        (4R,6R)-6-\{2-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl\}-4-hydroxyoxan-2-one 0
                        (R)-Kawain 0
                        (R)-Methysticin 0
                        10-Methoxyyangonin 0
                        11-Hydroxy-12-methoxydihydrokawain 0
                        11-Hydroxyyangonin 0
                        11-Methoxynoryangonin 0
                        11-Methoxyyangonin 0
                        2,4-dimethyl-6-oxo-N-[(2,4,6-trifluorophenyl)methyl]-3-pyrancarboxamide 0
                        2-[(1R,2R)-2-[(1R,8aR)-1-(3-furanyl)-8a-methyl-5-methylene-3-oxo-1,6,7,8-tetrahydro-2-benzopyran-6-yl]-2,6,6-trimethyl-5-oxo-1-cyclohex-3-enyl]acetic acid methyl ester 0
                        2-[2-(3,4-dimethoxyphenyl)ethyl]-4-methoxy-2,3-dihydropyran-6-one 0
                        2H-pyran-2-one 0
                        3-Hydroxy-4-methoxy-2-(2-phenylethenyl)-2,3-dihydropyran-6-one 0
                        4-coumaroyltriacetic acid lactone 0
                        4-hydroxy-4-methyloxan-2-one + 4
                        4-hydroxy-5-methyl-6-heptadecylpyran-2-one 0
                        4-hydroxy-5-methyl-6-pentadecylpyran-2-one 0
                        4-hydroxy-6-(2-oxohenicosyl)pyran-2-one 0
                        4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one 0
                        4-hydroxy-6-(2-oxoheptyl)pyran-2-one 0
                        4-hydroxy-6-(2-oxononadecyl)pyran-2-one 0
                        4-hydroxy-6-(2-oxotridecyl)pyran-2-one 0
                        4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one 0
                        4-hydroxy-6-heptadecylpyran-2-one 0
                        4-hydroxy-6-heptylpyran-2-one 0
                        4-hydroxy-6-nonadecylpyran-2-one 0
                        4-hydroxy-6-pentadecylpyran-2-one 0
                        4-hydroxy-6-pentylpyran-2-one 0
                        4-hydroxy-6-undecylpyran-2-one 0
                        4-methoxy-2-(2-phenylethenyl)-2,3-dihydropyran-6-one 0
                        5,6,7,8-Tetrahydroyangonin 0
                        5,6-Dehydrokawain 1
                        5,6-Dihydro-11-methoxyyangonin 0
                        5,6-Dihydroyangonin 0
                        5,7-dihydroxy-2-[1-(4-methoxy-6-oxo-6H-pyran-2-yl)-2-phenylethylamino]-[1,4]naphthoquinone 0
                        6-(3-hexenyl)tetrahydro-2H-pyran-2-one + 0
                        6-(acylmethyl)-4-hydroxy-2H-pyran-2-one + 0
                        6-[(E)-2-(2H-1,3-benzodioxol-5-yl)ethenyl]-5-hydroxy-4-methoxy-5,6-dihydro-2H-pyran-2-one 0
                        6-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-4-methoxy-2H-pyran-2-one 0
                        6-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-4-methoxy-2H-pyran-2-one 0
                        6-[2-(2,4-dihydroxy-6-methylphenyl)-2-oxoethyl]-4-hydroxy-pyran-2-one 0
                        6-[2-(2H-1,3-benzodioxol-5-yl)-1-hydroxyethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one 0
                        6-[2-(2H-1,3-benzodioxol-5-yl)-2-hydroxyethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one 0
                        6-[2-(2H-1,3-benzodioxol-5-yl)ethyl]-3-hydroxy-4-methoxy-5,6-dihydro-2H-pyran-2-one 0
                        6-[2-(6-hydroxy-2H-1,3-benzodioxol-5-yl)ethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one 0
                        6-alkyl-4-hydroxy-2H-pyran-2-one + 0
                        6-n-Pentyl-alpha-pyrone 0
                        7,8-Dihydroyangonin 0
                        Anibine 0
                        Aspernigrin C 0
                        Aspernigrin D 0
                        Citreoviridin 32
                        Dihydro-5,6-dehydrokawain 0
                        Dihydrokavain 1
                        Dihydromethysticin 0
                        Kawain 0
                        ML-236C 0
                        Methysticin 12
                        Nocapyrone E 0
                        Nocapyrone F 0
                        Nocapyrone G 0
                        Parasorbic acid 0
                        Penstyrylpyrone 0
                        Phoslactomycin B 0
                        Pyridinopyrone A 0
                        Pyridinopyrone B 0
                        Pyridinopyrone C 0
                        Pyrophen 0
                        Tetrahydro-11-methoxyiangonin 0
                        U100313 0
                        Yangonin 16
                        alternapyrone 0
                        asnipyrone A 0
                        asnipyrone B 0
                        aspernigrin B 0
                        aspyrone 0
                        brevipolide A 0
                        brevipolide B 0
                        chaetoglocin A 0
                        chaetoglocin B 0
                        compactin diol lactone 0
                        cryptocaryol A 0
                        cryptocaryol B 0
                        cryptocaryol C 0
                        cryptocaryol D 0
                        cryptocaryol E 0
                        cspyrone B1 0
                        dihydromonacolin L 0
                        fostriecin 4
                        gibepyrone A 0
                        hispidin 3
                        jasmolactone + 0
                        kavapyrone 0
                        lehualide E 0
                        lehualide F 0
                        lehualide G 0
                        lehualide H 0
                        lehualide I 0
                        lehualide J 0
                        lehualide K 0
                        lucibufagin C 0
                        mevastatin 35
                        monacolin J 0
                        monacolin L 0
                        myxopyronin A 0
                        nectriapyrones + 0
                        nigerapyrone A 0
                        nigerapyrone B 0
                        nigerapyrone C 0
                        nigerapyrone D 0
                        nigerapyrone E 0
                        nigerapyrone F 0
                        nigerapyrone G 0
                        nigerapyrone H 0
                        obolactone 0
                        p-Hydroxy-7,8-dihydrokavain 0
                        p-Hydroxykavain 0
                        prosolanapyrone + 0
                        salinipyrone A 0
                        salinipyrone B 0
                        sartorypyrone D 0
                        solanapyrone + 0
                        tetraacetic acid lactone 0
                        triacetate lactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  ester 17841
                                    carboxylic ester 17347
                                      lactone 13231
                                        delta-lactone 3390
                                          2-pyranones 97
                                            (+)-Dihydrokawain-5-ol 0
                                            (+)-cis-5,6-Dihydro-5-hydroxy-4-methoxy-6-(2-phenylethyl)-2H-pyran-2-one 0
                                            (+/-)-Dihydromethysticin 0
                                            (2R)-4-methoxy-2-(2-phenylethenyl)-2,3-dihydropyran-6-one 0
                                            (4R,6R)-6-\{2-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl\}-4-hydroxyoxan-2-one 0
                                            (R)-Kawain 0
                                            (R)-Methysticin 0
                                            10-Methoxyyangonin 0
                                            11-Hydroxy-12-methoxydihydrokawain 0
                                            11-Hydroxyyangonin 0
                                            11-Methoxynoryangonin 0
                                            11-Methoxyyangonin 0
                                            2,4-dimethyl-6-oxo-N-[(2,4,6-trifluorophenyl)methyl]-3-pyrancarboxamide 0
                                            2-[(1R,2R)-2-[(1R,8aR)-1-(3-furanyl)-8a-methyl-5-methylene-3-oxo-1,6,7,8-tetrahydro-2-benzopyran-6-yl]-2,6,6-trimethyl-5-oxo-1-cyclohex-3-enyl]acetic acid methyl ester 0
                                            2-[2-(3,4-dimethoxyphenyl)ethyl]-4-methoxy-2,3-dihydropyran-6-one 0
                                            2H-pyran-2-one 0
                                            3-Hydroxy-4-methoxy-2-(2-phenylethenyl)-2,3-dihydropyran-6-one 0
                                            4-coumaroyltriacetic acid lactone 0
                                            4-hydroxy-4-methyloxan-2-one + 4
                                            4-hydroxy-5-methyl-6-heptadecylpyran-2-one 0
                                            4-hydroxy-5-methyl-6-pentadecylpyran-2-one 0
                                            4-hydroxy-6-(2-oxohenicosyl)pyran-2-one 0
                                            4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one 0
                                            4-hydroxy-6-(2-oxoheptyl)pyran-2-one 0
                                            4-hydroxy-6-(2-oxononadecyl)pyran-2-one 0
                                            4-hydroxy-6-(2-oxotridecyl)pyran-2-one 0
                                            4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one 0
                                            4-hydroxy-6-heptadecylpyran-2-one 0
                                            4-hydroxy-6-heptylpyran-2-one 0
                                            4-hydroxy-6-nonadecylpyran-2-one 0
                                            4-hydroxy-6-pentadecylpyran-2-one 0
                                            4-hydroxy-6-pentylpyran-2-one 0
                                            4-hydroxy-6-undecylpyran-2-one 0
                                            4-methoxy-2-(2-phenylethenyl)-2,3-dihydropyran-6-one 0
                                            5,6,7,8-Tetrahydroyangonin 0
                                            5,6-Dehydrokawain 1
                                            5,6-Dihydro-11-methoxyyangonin 0
                                            5,6-Dihydroyangonin 0
                                            5,7-dihydroxy-2-[1-(4-methoxy-6-oxo-6H-pyran-2-yl)-2-phenylethylamino]-[1,4]naphthoquinone 0
                                            6-(3-hexenyl)tetrahydro-2H-pyran-2-one + 0
                                            6-(acylmethyl)-4-hydroxy-2H-pyran-2-one + 0
                                            6-[(E)-2-(2H-1,3-benzodioxol-5-yl)ethenyl]-5-hydroxy-4-methoxy-5,6-dihydro-2H-pyran-2-one 0
                                            6-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-4-methoxy-2H-pyran-2-one 0
                                            6-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-4-methoxy-2H-pyran-2-one 0
                                            6-[2-(2,4-dihydroxy-6-methylphenyl)-2-oxoethyl]-4-hydroxy-pyran-2-one 0
                                            6-[2-(2H-1,3-benzodioxol-5-yl)-1-hydroxyethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one 0
                                            6-[2-(2H-1,3-benzodioxol-5-yl)-2-hydroxyethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one 0
                                            6-[2-(2H-1,3-benzodioxol-5-yl)ethyl]-3-hydroxy-4-methoxy-5,6-dihydro-2H-pyran-2-one 0
                                            6-[2-(6-hydroxy-2H-1,3-benzodioxol-5-yl)ethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one 0
                                            6-alkyl-4-hydroxy-2H-pyran-2-one + 0
                                            6-n-Pentyl-alpha-pyrone 0
                                            7,8-Dihydroyangonin 0
                                            Anibine 0
                                            Aspernigrin C 0
                                            Aspernigrin D 0
                                            Citreoviridin 32
                                            Dihydro-5,6-dehydrokawain 0
                                            Dihydrokavain 1
                                            Dihydromethysticin 0
                                            Kawain 0
                                            ML-236C 0
                                            Methysticin 12
                                            Nocapyrone E 0
                                            Nocapyrone F 0
                                            Nocapyrone G 0
                                            Parasorbic acid 0
                                            Penstyrylpyrone 0
                                            Phoslactomycin B 0
                                            Pyridinopyrone A 0
                                            Pyridinopyrone B 0
                                            Pyridinopyrone C 0
                                            Pyrophen 0
                                            Tetrahydro-11-methoxyiangonin 0
                                            U100313 0
                                            Yangonin 16
                                            alternapyrone 0
                                            asnipyrone A 0
                                            asnipyrone B 0
                                            aspernigrin B 0
                                            aspyrone 0
                                            brevipolide A 0
                                            brevipolide B 0
                                            chaetoglocin A 0
                                            chaetoglocin B 0
                                            compactin diol lactone 0
                                            cryptocaryol A 0
                                            cryptocaryol B 0
                                            cryptocaryol C 0
                                            cryptocaryol D 0
                                            cryptocaryol E 0
                                            cspyrone B1 0
                                            dihydromonacolin L 0
                                            fostriecin 4
                                            gibepyrone A 0
                                            hispidin 3
                                            jasmolactone + 0
                                            kavapyrone 0
                                            lehualide E 0
                                            lehualide F 0
                                            lehualide G 0
                                            lehualide H 0
                                            lehualide I 0
                                            lehualide J 0
                                            lehualide K 0
                                            lucibufagin C 0
                                            mevastatin 35
                                            monacolin J 0
                                            monacolin L 0
                                            myxopyronin A 0
                                            nectriapyrones + 0
                                            nigerapyrone A 0
                                            nigerapyrone B 0
                                            nigerapyrone C 0
                                            nigerapyrone D 0
                                            nigerapyrone E 0
                                            nigerapyrone F 0
                                            nigerapyrone G 0
                                            nigerapyrone H 0
                                            obolactone 0
                                            p-Hydroxy-7,8-dihydrokavain 0
                                            p-Hydroxykavain 0
                                            prosolanapyrone + 0
                                            salinipyrone A 0
                                            salinipyrone B 0
                                            sartorypyrone D 0
                                            solanapyrone + 0
                                            tetraacetic acid lactone 0
                                            triacetate lactone 0
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