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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nilutamide
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Accession:CHEBI:7573 term browser browse the term
Definition:An imidazolidinone that has formula C12H10F3N3O4.
Synonyms:exact_synonym: 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
 related_synonym: 5,5-Dimethyl-3-(alpha,alpha,alpha-trifluoro-4-nitro-m-tolyl)hydantoin;   Formula=C12H10F3N3O4;   InChI=1S/C12H10F3N3O4/c1-11(2)9(19)17(10(20)16-11)6-3-4-8(18(21)22)7(5-6)12(13,14)15/h3-5H,1-2H3,(H,16,20);   InChIKey=XWXYUMMDTVBTOU-UHFFFAOYSA-N;   Nilandron;   SMILES=CC1(C)NC(=O)N(C1=O)c1ccc(c(c1)C(F)(F)F)[N+]([O-])=O;   nilutamida;   nilutamidum
 xref: Beilstein:841906;   CAS:63612-50-0;   DrugBank:DB00665;   Drug_Central:1933;   KEGG:C08164;   KEGG:D00965;   LINCS:LSM-2513
 xref_mesh: MESH:C021277
 xref: Patent:DE2649925;   Patent:US4097578;   Wikipedia:Nilutamide


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nilutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases expression ISO nilutamide results in increased expression of AKT1 protein CTD PMID:16616092 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ar androgen receptor affects binding
multiple interactions
decreases activity
increases response to substance		 ISO nilutamide binds to AR protein
[AR protein mutant form results in increased susceptibility to nilutamide] which results in increased activity of AR protein mutant form; nilutamide analog binds to and affects the localization of AR protein; nilutamide binds to and results in decreased activity of AR protein; nilutamide inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; nilutamide inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; nilutamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; nilutamide inhibits the reaction [Metribolone results in increased activity of AR protein]; nilutamide inhibits the reaction [mibolerone affects the localization of AR protein]
nilutamide results in decreased activity of AR protein		 CTD PMID:15509168 PMID:16125883 PMID:16857237 PMID:18324785 PMID:18973785 More... NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO nilutamide results in decreased expression of CDKN1B protein CTD PMID:16616092 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO nilutamide results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO nilutamide binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP nilutamide inhibits the reaction [Dihydrotestosterone results in decreased activity of GAPDH protein] CTD PMID:10650946 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions ISO nilutamide inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA] CTD PMID:16496412 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions EXP nilutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of IGF1R protein] CTD PMID:10650946 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO nilutamide binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO nilutamide binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO nilutamide binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
Term paths to the root
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  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            antineoplastic agent 17823
              nilutamide 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            organic hydride 18691
                              organic fundamental parent 18691
                                hydrocarbon 18442
                                  halohydrocarbon 15851
                                    haloalkane 12900
                                      fluoroalkane 9224
                                        fluoromethanes 6773
                                          tetrafluoromethane 6773
                                            trifluoromethyl group 6773
                                              (trifluoromethyl)benzenes 6773
                                                nilutamide 11
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