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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein] |
CTD |
PMID:25813982 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Ace |
angiotensin I converting enzyme |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] |
CTD |
PMID:15932931 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions decreases expression |
ISO |
RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of ACTA2 protein] RTKI cpd results in decreased expression of ACTA2 protein |
CTD |
PMID:35850069 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adrb1 |
adrenoceptor beta 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]] |
CTD |
PMID:18787115 |
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NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [AGT protein promotes the reaction [SP1 protein binds to TGFB1 promoter]]; RTKI cpd inhibits the reaction [AGT protein results in increased expression of SP1 mRNA]; RTKI cpd inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [AGT protein results in increased phosphorylation of EGFR protein] |
CTD |
PMID:15849355 PMID:25398788 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP ISO |
RTKI cpd inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [hexabromocyclododecane promotes the reaction [FSHB protein results in increased phosphorylation of AKT1 protein]]; RTKI cpd inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein] RTKI cpd inhibits the reaction [Cadmium Chloride results in increased cleavage of AKT1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of AKT1 protein] |
CTD |
PMID:11309286 PMID:15177934 PMID:15849355 PMID:19233221 PMID:19946718 PMID:24015256 PMID:24071787 PMID:25118938 PMID:25398788 More...
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alb |
albumin |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CXCL8 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:16908450 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions |
ISO |
[RTKI cpd co-treated with AG 1879] inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; RTKI cpd inhibits the reaction [Nicotine results in increased expression of ALOX5 protein] RTKI cpd inhibits the reaction [Acrolein results in increased expression of ALOX5 protein] |
CTD |
PMID:14569062 PMID:20153347 |
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NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Angpt1 |
angiopoietin 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Iloprost results in increased expression of ANGPT1 mRNA] |
CTD |
PMID:16373414 |
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NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
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G |
Angpt2 |
angiopoietin 2 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Iloprost results in increased expression of ANGPT2 mRNA] |
CTD |
PMID:16373414 |
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NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [EGF protein results in decreased expression of AR protein]; RTKI cpd inhibits the reaction [Particulate Matter results in increased secretion of AR protein]; RTKI cpd inhibits the reaction [Vehicle Emissions results in increased secretion of AR protein] |
CTD |
PMID:16472761 PMID:24555532 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Areg |
amphiregulin |
multiple interactions decreases activity |
ISO |
RTKI cpd inhibits the reaction [[AREG protein co-treated with Estradiol] results in increased phosphorylation of EGFR protein] RTKI cpd results in decreased activity of AREG protein |
CTD |
PMID:15706222 PMID:21185374 |
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NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
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G |
Atf1 |
activating transcription factor 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein] |
CTD |
PMID:16671086 |
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NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
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G |
Atp1a2 |
ATPase Na+/K+ transporting subunit alpha 2 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Ammonia results in increased expression of ATP1A2 mRNA]; RTKI cpd inhibits the reaction [Ammonia results in increased expression of ATP1A2 protein] |
CTD |
PMID:20447429 |
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NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP ISO |
RTKI cpd results in increased expression of and results in increased activity of BAX protein ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; RTKI cpd inhibits the reaction [Estradiol results in decreased expression of BAX protein] RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]] |
CTD |
PMID:18371937 PMID:34724321 PMID:35716406 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in increased expression of BCL2 protein]]; RTKI cpd inhibits the reaction [Estradiol results in increased expression of BCL2 protein] RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]] |
CTD |
PMID:34724321 PMID:35716406 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
EXP |
RTKI cpd results in decreased expression of BCL2L1 mRNA; RTKI cpd results in decreased expression of BCL2L1 protein |
CTD |
PMID:18371937 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
ISO |
[RTKI cpd results in decreased activity of EGFR protein] which results in decreased expression of BIRC5 protein RTKI cpd results in decreased expression of BIRC5 protein |
CTD |
PMID:21268125 PMID:29974605 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Bmp4 |
bone morphogenetic protein 4 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [antimonite results in decreased expression of BMP4 mRNA]; RTKI cpd inhibits the reaction [arsenite results in decreased expression of BMP4 mRNA] |
CTD |
PMID:17400267 |
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NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
RTKI cpd promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein] ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; RTKI cpd inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein] RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CASP3 mRNA]] |
CTD |
PMID:19233221 PMID:34724321 PMID:35716406 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cav1 |
caveolin 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Rosiglitazone results in increased expression of CAV1] |
CTD |
PMID:18507034 |
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NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Ccnb1 |
cyclin B1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Cadmium Chloride results in increased expression of CCNB1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CCNB1 protein] |
CTD |
PMID:26385184 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression |
ISO |
RTKI cpd inhibits the reaction [[Fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA] RTKI cpd results in decreased expression of CCND1 protein |
CTD |
PMID:28446726 PMID:29974605 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
multiple interactions decreases expression |
ISO |
RTKI cpd inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CCNE1 protein] RTKI cpd results in decreased expression of CCNE1 protein |
CTD |
PMID:15923621 PMID:26385184 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdh1 |
cadherin 1 |
increases expression |
ISO |
RTKI cpd results in increased expression of CDH1 protein |
CTD |
PMID:25856345 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CDK1 protein] |
CTD |
PMID:26385184 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Cadmium Chloride results in increased expression of CDK2 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CDK2 protein] |
CTD |
PMID:26385184 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein] |
CTD |
PMID:15734884 PMID:16283431 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO EXP |
RTKI cpd inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein] RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of CREB1 protein]; RTKI cpd inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:16671086 PMID:17272394 PMID:17322281 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CSF2 protein]; RTKI cpd inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein] |
CTD |
PMID:16908450 PMID:19460412 PMID:22581348 |
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NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions decreases expression |
ISO |
RTKI cpd inhibits the reaction [arsenite affects the localization of CTNNB1 protein] RTKI cpd results in decreased expression of CTNNB1 protein |
CTD |
PMID:17400267 PMID:29974605 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Cyld |
CYLD lysine 63 deubiquitinase |
increases expression |
ISO |
[RTKI cpd results in increased expression of CYLD protein] which results in increased expression of NFKBIA protein; RTKI cpd results in increased expression of CYLD mRNA; RTKI cpd results in increased expression of CYLD protein |
CTD |
PMID:21109933 |
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NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA] |
CTD |
PMID:24639330 |
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NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO EXP |
RTKI cpd inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA] RTKI cpd inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]; RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]] |
CTD |
PMID:16261333 PMID:17974986 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO EXP |
RTKI cpd inhibits the reaction [EGF protein affects the localization of FOXO3 protein]; RTKI cpd inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in decreased expression of AR protein]; RTKI cpd inhibits the reaction [EGF protein results in increased abundance of Calcium]; RTKI cpd inhibits the reaction [EGF protein results in increased activity of STAT3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CCNB1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of CDK2 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of GPER1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein]; RTKI cpd inhibits the reaction [EGF protein results in increased secretion of MMP1 protein]; RTKI cpd inhibits the reaction [Estradiol promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]]; RTKI cpd promotes the reaction [Amiodarone inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]] RTKI cpd inhibits the reaction [EGF protein results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased susceptibility to Desoxycorticosterone] RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK7 protein] |
CTD |
PMID:10516208 PMID:11309286 PMID:11527950 PMID:11751714 PMID:14737115 PMID:15849355 PMID:16472761 PMID:17656145 PMID:19749156 PMID:21185374 PMID:25841994 PMID:25856345 PMID:25969534 PMID:26385184 PMID:26470790 PMID:26515726 PMID:28974440 PMID:36430902 More...
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NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases activity decreases phosphorylation decreases expression |
ISO EXP |
[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased chemical synthesis of Oxygen]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of and results in increased activity of NOS3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Progesterone]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to 5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to FSHB protein; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to Hexachlorobenzene; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to Topotecan; RTKI cpd inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [[AREG protein co-treated with Estradiol] results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Cadmium results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [Cadmium results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Capsaicin results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [EGFR protein binds to GPER1 protein]; RTKI cpd inhibits the reaction [Estradiol promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]]; RTKI cpd inhibits the reaction [Estradiol results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of EGFR protein]; RTKI cpd promotes the reaction [Amiodarone inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]] [[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased expression of MT2 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased expression of BIRC5 protein; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased phosphorylation of STAT3 protein; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to butaprost; RTKI cpd inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Arsenic affects the localization of EGFR protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Fluoxetine results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein]; RTKI cpd results in decreased phosphorylation of and results in decreased activity of EGFR protein [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Genistein results in increased secretion of Testosterone]; RTKI cpd inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [AGT protein results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [sodium arsenite promotes the reaction [SHC1 protein modified form binds to EGFR protein binds to GRB protein]]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of EGFR protein] RTKI cpd results in decreased phosphorylation of EGFR protein RTKI cpd results in decreased expression of EGFR protein modified form |
CTD |
PMID:9710602 PMID:12794006 PMID:15177934 PMID:15459120 PMID:15504454 PMID:15531749 PMID:15574683 PMID:15849355 PMID:15923621 PMID:16261333 PMID:16472761 PMID:18618485 PMID:18633435 PMID:18758753 PMID:18787115 PMID:19059320 PMID:19133285 PMID:19233221 PMID:19749156 PMID:19854188 PMID:20433816 PMID:20619260 PMID:20660715 PMID:20850495 PMID:21185374 PMID:21205633 PMID:21220312 PMID:21268125 PMID:21300668 PMID:21520325 PMID:21568938 PMID:23376140 PMID:23538097 PMID:23673518 PMID:25343777 PMID:25398788 PMID:25813982 PMID:25856345 PMID:25969534 PMID:26385184 PMID:26514923 PMID:26515726 PMID:27071941 PMID:28974440 PMID:29974605 PMID:32159786 PMID:33148531 PMID:35850069 More...
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of EGR1 protein] |
CTD |
PMID:15292961 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
multiple interactions |
ISO |
[RTKI cpd co-treated with AG-879] results in decreased phosphorylation of ERBB2 protein RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ERBB2 mRNA]] |
CTD |
PMID:18618485 PMID:35716406 |
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NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Erbb4 |
erb-b2 receptor tyrosine kinase 4 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ERBB4 mRNA]] |
CTD |
PMID:35716406 |
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NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
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G |
Errfi1 |
ERBB receptor feedback inhibitor 1 |
decreases expression |
ISO |
RTKI cpd results in decreased expression of ERRFI1 protein |
CTD |
PMID:35850069 |
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NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [bisphenol A results in increased phosphorylation of ESR1 protein] ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased cleavage of CASP3 protein]]; ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in increased expression of BCL2 protein]] |
CTD |
PMID:21813366 PMID:34724321 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
F11r |
F11 receptor |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Poly I-C results in decreased expression of F11R protein] |
CTD |
PMID:20932985 |
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NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
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G |
Fgf2 |
fibroblast growth factor 2 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Iloprost results in increased expression of FGF2 mRNA] |
CTD |
PMID:16373414 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased secretion of FLT1 protein]; RTKI cpd inhibits the reaction [calcium silicate results in increased secretion of FLT1 protein] |
CTD |
PMID:21762757 |
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NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO EXP |
RTKI cpd inhibits the reaction [afimoxifene results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [afimoxifene results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [Atrazine results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [EGF protein results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [Estradiol results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [Genistein results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [Quercetin results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased expression of FOS protein] RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of FOS mRNA] RTKI cpd inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [[Fulvestrant co-treated with bisphenol A] results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [Estradiol results in increased expression of FOS mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOS mRNA] |
CTD |
PMID:9710602 PMID:10516208 PMID:12154012 PMID:15090535 PMID:18758753 PMID:19749156 PMID:19935718 PMID:21813366 PMID:23274518 PMID:25616260 PMID:28446726 More...
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of FOSB protein] |
CTD |
PMID:18758753 |
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NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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G |
Foxo3 |
forkhead box O3 |
multiple interactions |
ISO |
[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]; RTKI cpd inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone affects the localization of FOXO3 protein]; RTKI cpd inhibits the reaction [EGF protein affects the localization of FOXO3 protein]; RTKI cpd inhibits the reaction [Estradiol affects the localization of FOXO3 protein] |
CTD |
PMID:23673518 PMID:26470790 |
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NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO EXP |
[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [FSHB protein results in increased chemical synthesis of Progesterone]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to FSHB protein RTKI cpd inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [hexabromocyclododecane inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]]; RTKI cpd inhibits the reaction [hexabromocyclododecane promotes the reaction [FSHB protein results in increased phosphorylation of AKT1 protein]]; RTKI cpd inhibits the reaction [hexabromocyclododecane promotes the reaction [FSHB protein results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [hexabromocyclododecane promotes the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein]]; RTKI cpd promotes the reaction [FSHB protein results in increased expression of LHCGR mRNA] |
CTD |
PMID:21520325 PMID:24071787 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Gast |
gastrin |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [lead acetate results in increased expression of GAST mRNA] |
CTD |
PMID:23765435 |
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NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions decreases expression |
EXP |
Doxorubicin promotes the reaction [RTKI cpd results in decreased expression of GCLC protein] |
CTD |
PMID:18371937 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gnaq |
G protein subunit alpha q |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]] |
CTD |
PMID:14676212 |
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NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
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G |
Gper1 |
G protein-coupled estrogen receptor 1 |
multiple interactions |
ISO EXP |
RTKI cpd inhibits the reaction [EGF protein results in increased expression of GPER1 protein]; RTKI cpd inhibits the reaction [EGFR protein binds to GPER1 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased expression of GPER1 protein] RTKI cpd inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of GPER1 protein] RTKI cpd inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein] |
CTD |
PMID:19749156 PMID:22645130 PMID:23274518 |
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NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
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G |
Has2 |
hyaluronan synthase 2 |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [LHB protein results in increased expression of HAS2 mRNA] |
CTD |
PMID:15459120 |
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NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
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G |
Hbegf |
heparin-binding EGF-like growth factor |
multiple interactions decreases expression increases expression |
ISO EXP |
RTKI cpd inhibits the reaction [vanadium pentoxide results in increased expression of HBEGF mRNA] RTKI cpd results in decreased expression of HBEGF mRNA; RTKI cpd results in decreased expression of HBEGF protein RTKI cpd results in increased expression of HBEGF mRNA |
CTD |
PMID:11159045 PMID:22048644 PMID:26800359 |
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NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
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G |
Hes1 |
hes family bHLH transcription factor 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [arsenite results in decreased expression of HES1 mRNA] |
CTD |
PMID:18633435 |
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NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [arsenite results in increased expression of HMOX1 protein] |
CTD |
PMID:17196236 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Htr2b |
5-hydroxytryptamine receptor 2B |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:18758753 |
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NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108
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G |
Il6 |
interleukin 6 |
multiple interactions decreases expression |
ISO |
RTKI cpd affects the reaction [Capsaicin results in increased secretion of IL6 protein]; RTKI cpd inhibits the reaction [hexabromocyclododecane results in increased expression of IL6 protein]; RTKI cpd inhibits the reaction [pentabromodiphenyl ether results in increased expression of IL6 protein]; RTKI cpd inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL6 protein]; RTKI cpd inhibits the reaction [tetrabromobisphenol A results in increased expression of IL6 protein] RTKI cpd results in decreased expression of IL6 protein |
CTD |
PMID:20619260 PMID:24184330 PMID:24844442 PMID:26718265 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ivl |
involucrin |
multiple interactions increases expression |
ISO |
RTKI cpd inhibits the reaction [arsenite results in decreased expression of IVL mRNA] RTKI cpd results in increased expression of IVL protein |
CTD |
PMID:18633435 |
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NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
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G |
Jag1 |
jagged canonical Notch ligand 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [arsenite results in decreased expression of JAG1 mRNA]; RTKI cpd inhibits the reaction [arsenite results in decreased expression of JAG1 protein] |
CTD |
PMID:18633435 |
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NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
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G |
Jak3 |
Janus kinase 3 |
multiple interactions |
ISO |
RTKI cpd results in decreased phosphorylation of and results in decreased activity of JAK3 protein |
CTD |
PMID:16932349 |
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NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO EXP |
RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of JUN protein] RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA] RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of JUN mRNA] |
CTD |
PMID:9710602 PMID:11329622 PMID:12154012 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Klk1c10 |
kallikrein 1-related peptidase C10 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein] |
CTD |
PMID:16472761 |
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NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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G |
Krt1 |
keratin 1 |
increases expression |
ISO |
RTKI cpd results in increased expression of KRT1 protein |
CTD |
PMID:18633435 |
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NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
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G |
Krt10 |
keratin 10 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [arsenite results in decreased expression of KRT10 mRNA]; RTKI cpd inhibits the reaction [arsenite results in decreased expression of KRT10 protein] |
CTD |
PMID:18633435 |
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NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
ISO EXP |
RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] RTKI cpd inhibits the reaction [LHB protein results in increased expression of HAS2 mRNA]; RTKI cpd inhibits the reaction [LHB protein results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [LHB protein results in increased expression of TNFAIP6 mRNA]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of EGFR protein] |
CTD |
PMID:15459120 PMID:21220312 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Lhcgr |
luteinizing hormone/choriogonadotropin receptor |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [hexabromocyclododecane inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]]; RTKI cpd promotes the reaction [FSHB protein results in increased expression of LHCGR mRNA] |
CTD |
PMID:24071787 |
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NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAP2K1 protein] |
CTD |
PMID:16269455 |
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NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAP2K2 protein] |
CTD |
PMID:16269455 |
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NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO EXP |
[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [arsenite results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Atrazine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Calcitriol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [calcium silicate results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Diacetyl results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Iloprost results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Lead results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Thrombin results in increased phosphorylation of MAPK1 protein]; RTKI cpd results in decreased phosphorylation of and results in decreased activity of MAPK1 protein RTKI cpd results in decreased phosphorylation of MAPK1 protein RTKI cpd inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [hexabromocyclododecane promotes the reaction [FSHB protein results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein] [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein] |
CTD |
PMID:9710602 PMID:10516208 PMID:11309286 PMID:11329622 PMID:12761878 PMID:14674888 PMID:14676212 PMID:14737115 PMID:15177934 PMID:15247267 PMID:15319441 PMID:15504454 PMID:15574683 PMID:15843167 PMID:16261333 PMID:16269455 PMID:16373414 PMID:16671086 PMID:16908450 PMID:17272394 PMID:17656145 PMID:18360054 PMID:18758753 PMID:18787115 PMID:19233221 PMID:19850060 PMID:19854188 PMID:19946718 PMID:20153347 PMID:20466046 PMID:20660715 PMID:20850495 PMID:20875696 PMID:21205633 PMID:21220312 PMID:21300668 PMID:21762757 PMID:22552965 PMID:23376140 PMID:23538097 PMID:23765435 PMID:24015256 PMID:24071787 PMID:24106166 PMID:25312822 PMID:25343777 PMID:25616260 PMID:25744307 PMID:25856345 PMID:26006730 PMID:26385184 PMID:26514923 PMID:27071941 PMID:28446726 PMID:28974440 PMID:30851105 PMID:31075703 PMID:33148531 PMID:35850069 PMID:36430902 More...
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:11329622 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO EXP |
[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [arsenite results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Atrazine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Calcitriol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [calcium silicate results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Diacetyl results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Iloprost results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Lead results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Thrombin results in increased phosphorylation of MAPK3 protein]; RTKI cpd results in decreased phosphorylation of and results in decreased activity of MAPK3 protein RTKI cpd results in decreased phosphorylation of MAPK3 protein RTKI cpd inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [EGF protein results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [EGFR protein affects the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [hexabromocyclododecane promotes the reaction [FSHB protein results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Metribolone results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Uridine Triphosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein] [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:9710602 PMID:10516208 PMID:11309286 PMID:11329622 PMID:12761878 PMID:14674888 PMID:14676212 PMID:14737115 PMID:15177934 PMID:15247267 PMID:15319441 PMID:15504454 PMID:15574683 PMID:15843167 PMID:16261333 PMID:16269455 PMID:16373414 PMID:16671086 PMID:16908450 PMID:17272394 PMID:17656145 PMID:18360054 PMID:18758753 PMID:18787115 PMID:19233221 PMID:19850060 PMID:19854188 PMID:19946718 PMID:20153347 PMID:20466046 PMID:20660715 PMID:20850495 PMID:20875696 PMID:21205633 PMID:21220312 PMID:21300668 PMID:21762757 PMID:22552965 PMID:23376140 PMID:23538097 PMID:23765435 PMID:24015256 PMID:24071787 PMID:24106166 PMID:25312822 PMID:25343777 PMID:25616260 PMID:25744307 PMID:25856345 PMID:26006730 PMID:26385184 PMID:26514923 PMID:27071941 PMID:28446726 PMID:28974440 PMID:30851105 PMID:31075703 PMID:33148531 PMID:35850069 PMID:36430902 More...
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk7 |
mitogen-activated protein kinase 7 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of MAPK7 protein] |
CTD |
PMID:14737115 |
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NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO EXP |
RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK8 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein] RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased activity of MAPK8 protein] |
CTD |
PMID:11329622 PMID:15574683 PMID:26514923 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Cadmium results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:26514923 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
EXP |
RTKI cpd results in decreased expression of MCL1 mRNA; RTKI cpd results in decreased expression of MCL1 protein |
CTD |
PMID:18371937 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mir126a |
microRNA 126a |
multiple interactions |
ISO |
RTKI cpd promotes the reaction [Asbestos, Crocidolite results in increased expression of MIR126 mRNA] |
CTD |
PMID:32006662 |
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NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180
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G |
Mir21 |
microRNA 21 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased expression of MIR21 mRNA]; RTKI cpd inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA] |
CTD |
PMID:25969534 |
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NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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G |
Mir222 |
microRNA 222 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased expression of MIR222 mRNA] |
CTD |
PMID:32006662 |
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NCBI chr X:3,428,904...3,429,006
Ensembl chr X:3,428,904...3,429,006
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G |
Mmp1 |
matrix metallopeptidase 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [EGF protein results in increased secretion of MMP1 protein]; RTKI cpd inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; RTKI cpd inhibits the reaction [Histamine results in increased secretion of MMP1 protein] |
CTD |
PMID:17656145 |
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NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA] |
CTD |
PMID:16571779 |
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NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G |
Mmp14 |
matrix metallopeptidase 14 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA] |
CTD |
PMID:19661247 |
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NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; RTKI cpd inhibits the reaction [Hexachlorobenzene results in increased expression of MMP2 protein] |
CTD |
PMID:23462309 PMID:25312822 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp7 |
matrix metallopeptidase 7 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [antimonite results in increased expression of MMP7 mRNA]; RTKI cpd inhibits the reaction [arsenite results in increased expression of MMP7 mRNA] |
CTD |
PMID:17400267 |
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NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Acrolein results in increased expression of MMP9 mRNA]; RTKI cpd inhibits the reaction [bisphenol A results in increased expression of MMP9 protein]; RTKI cpd inhibits the reaction [Cadmium results in increased expression of MMP9 mRNA]; RTKI cpd inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein]; RTKI cpd inhibits the reaction [sodium arsenite results in increased secretion of MMP9 protein] |
CTD |
PMID:15504454 PMID:18006877 PMID:23462309 PMID:25312822 PMID:26514923 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mt2A |
metallothionein 2A |
multiple interactions |
ISO |
[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased expression of MT2 protein] |
CTD |
PMID:23376140 |
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NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MTOR protein]; RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MTOR protein] |
CTD |
PMID:20466046 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [[Smoke results in increased abundance of Particulate Matter] which results in increased expression of MUC5AC mRNA]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC mRNA]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]; RTKI cpd inhibits the reaction [Particulate Matter results in increased expression of MUC5AC mRNA]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MUC5AC mRNA] |
CTD |
PMID:10640773 PMID:20971882 PMID:22820758 PMID:31944254 |
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NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions decreases phosphorylation |
ISO |
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; RTKI cpd inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein] RTKI cpd results in decreased phosphorylation of NFE2L2 protein |
CTD |
PMID:24015256 PMID:33148531 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
increases expression |
ISO |
[RTKI cpd results in increased expression of CYLD protein] which results in increased expression of NFKBIA protein |
CTD |
PMID:21109933 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of and results in increased activity of NOS3 protein] |
CTD |
PMID:21300668 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Notch1 |
notch receptor 1 |
multiple interactions increases expression |
ISO |
RTKI cpd inhibits the reaction [arsenite results in decreased expression of NOTCH1 protein modified form]; RTKI cpd inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] RTKI cpd results in increased expression of NOTCH1 protein modified form |
CTD |
PMID:18633435 PMID:25118938 |
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NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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G |
Nox4 |
NADPH oxidase 4 |
multiple interactions increases expression |
EXP |
Doxorubicin promotes the reaction [RTKI cpd results in increased expression of NOX4 mRNA] |
CTD |
PMID:18371937 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Nppa |
natriuretic peptide A |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [GNAQ protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]] |
CTD |
PMID:14676212 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nrg1 |
neuregulin 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ERBB2 mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ERBB4 mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PIK3R1 mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CASP3 mRNA]] |
CTD |
PMID:35716406 |
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NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
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G |
Nts |
neurotensin |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [NTS protein results in increased expression of CXCL8 mRNA]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [NTS protein results in increased secretion of CXCL8 protein] |
CTD |
PMID:15177934 PMID:15247267 |
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NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
RTKI cpd results in decreased expression of PCNA protein |
CTD |
PMID:15923621 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PIK3R1 mRNA]] |
CTD |
PMID:35716406 |
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NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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G |
Pla2g4a |
phospholipase A2 group 4A |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA] RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [Fluoxetine results in increased expression of PLA2G4A protein] |
CTD |
PMID:19662385 PMID:20850495 |
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NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [antimonite results in increased expression of PPARD mRNA]; RTKI cpd inhibits the reaction [arsenite results in increased expression of PPARD mRNA] |
CTD |
PMID:17400267 |
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NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA] |
CTD |
PMID:31075703 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkca |
protein kinase C, alpha |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein] |
CTD |
PMID:19854188 |
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NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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G |
Prkcd |
protein kinase C, delta |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [sodium arsenite affects the expression of PRKCD protein]; RTKI cpd inhibits the reaction [sodium arsenite results in decreased phosphorylation of PRKCD protein] |
CTD |
PMID:20082316 |
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NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO EXP |
RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 protein] RTKI cpd inhibits the reaction [TRPV1 gene mutant form promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of PTGS2 protein]] RTKI cpd inhibits the reaction [LHB protein results in increased expression of PTGS2 mRNA] |
CTD |
PMID:15459120 PMID:20660715 PMID:20850495 PMID:24639330 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptk2 |
protein tyrosine kinase 2 |
multiple interactions |
ISO |
[RTKI cpd co-treated with bisphenol A] results in increased phosphorylation of PTK2 protein |
CTD |
PMID:32325111 |
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NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 protein] |
CTD |
PMID:24639330 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Runx2 |
RUNX family transcription factor 2 |
decreases expression |
EXP |
RTKI cpd results in decreased expression of RUNX2 mRNA |
CTD |
PMID:20197312 |
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NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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G |
Shc1 |
SHC adaptor protein 1 |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of SHC1 protein alternative form]; RTKI cpd inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; RTKI cpd inhibits the reaction [sodium arsenite promotes the reaction [SHC1 protein modified form binds to EGFR protein binds to GRB protein]]; RTKI cpd inhibits the reaction [sodium arsenite results in increased phosphorylation of SHC1 protein] |
CTD |
PMID:9710602 PMID:19168439 |
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NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
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G |
Slc1a2 |
solute carrier family 1 member 2 |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of SLC1A2 protein]; RTKI cpd inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]; RTKI cpd inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]; RTKI cpd inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; RTKI cpd inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein] |
CTD |
PMID:22645130 PMID:24782323 |
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NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [AGT protein promotes the reaction [SP1 protein binds to TGFB1 promoter]]; RTKI cpd inhibits the reaction [AGT protein results in increased expression of SP1 mRNA] |
CTD |
PMID:25398788 |
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NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO EXP |
[[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein] RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein]; RTKI cpd inhibits the reaction [Nicotine results in increased phosphorylation of SRC protein] RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein] |
CTD |
PMID:14569062 PMID:23376140 PMID:25813982 PMID:25856345 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [Glucose results in increased activity of and results in increased cleavage of SREBF1 protein] |
CTD |
PMID:22031849 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [bisphenol A results in increased expression of STAR mRNA] |
CTD |
PMID:31075703 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions decreases expression |
ISO |
RTKI cpd inhibits the reaction [bisphenol A results in increased expression of STAT3 mRNA]; RTKI cpd inhibits the reaction [EGF protein results in increased activity of STAT3 protein] [[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased phosphorylation of STAT3 protein RTKI cpd results in decreased expression of STAT3 protein modified form |
CTD |
PMID:21268125 PMID:21909620 PMID:23376140 PMID:25841994 PMID:29974605 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Stat5b |
signal transducer and activator of transcription 5B |
multiple interactions |
ISO |
[RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein] |
CTD |
PMID:21205633 |
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NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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G |
Tac1 |
tachykinin, precursor 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:15319441 |
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NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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G |
Tfap2a |
transcription factor AP-2 alpha |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [butylbenzyl phthalate affects the localization of TFAP2A protein]; RTKI cpd inhibits the reaction [Dibutyl Phthalate affects the localization of TFAP2A protein] |
CTD |
PMID:22552774 |
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NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507
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G |
Tgfa |
transforming growth factor alpha |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Particulate Matter results in increased secretion of TGFA protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased expression of FOS protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased expression of GPER1 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [TGFA protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Vehicle Emissions results in increased secretion of TGFA protein] |
CTD |
PMID:11309286 PMID:19749156 PMID:24555532 |
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NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases expression |
EXP ISO |
RTKI cpd inhibits the reaction [AGT protein promotes the reaction [SP1 protein binds to TGFB1 promoter]] RTKI cpd results in decreased expression of TGFB1 protein RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of TGFB1 protein] |
CTD |
PMID:25398788 PMID:35850069 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Poly I-C results in increased secretion of TNF protein] |
CTD |
PMID:20932985 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfaip6 |
TNF alpha induced protein 6 |
multiple interactions |
EXP |
RTKI cpd inhibits the reaction [LHB protein results in increased expression of TNFAIP6 mRNA] |
CTD |
PMID:15459120 |
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NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of TP53 protein] |
CTD |
PMID:15734884 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [TRPV1 gene mutant form promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Capsaicin] results in increased expression of PTGS2 protein]] |
CTD |
PMID:20660715 |
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NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
RTKI cpd inhibits the reaction [Asbestos, Crocidolite results in increased secretion of VEGFA protein]; RTKI cpd inhibits the reaction [calcium silicate results in increased secretion of VEGFA protein] |
CTD |
PMID:21762757 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vim |
vimentin |
decreases expression multiple interactions |
ISO |
RTKI cpd results in decreased expression of VIM protein RTKI cpd inhibits the reaction [sodium arsenite results in increased expression of VIM protein]; RTKI cpd inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VIM protein] |
CTD |
PMID:25856345 PMID:26971374 PMID:35850069 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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