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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester
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Accession:CHEBI:75391 term browser browse the term
Definition:An organic phosphonate that is the trisacetoxymethylester derivative of naphthalene substituted hydroxymethylphosphonic acid. It has been found to inhibit insulin receptor tyrosine kinase activity and insulin stimulated glucose oxidation.
Synonyms:related_synonym: 3-[(acetyloxy)methoxy]-4-(naphthalen-2-yl)-3-oxido-8-oxo-2,5,7-trioxa-3lambda(5)-phosphanon-1-yl acetate;   Formula=C20H23O10P;   HNMPA-(AM)3;   InChI=1S/C20H23O10P/c1-14(21)25-11-28-20(19-9-8-17-6-4-5-7-18(17)10-19)31(24,29-12-26-15(2)22)30-13-27-16(3)23/h4-10,20H,11-13H2,1-3H3;   InChIKey=UQODAZKXEREJLZ-UHFFFAOYSA-N;   SMILES=CC(=O)OCOC(c1ccc2ccccc2c1)P(=O)(OCOC(C)=O)OCOC(C)=O
 xref: LINCS:LSM-6443
 xref_mesh: MESH:C519736
 xref: PMID:2550060;   Reaxys:11322049


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hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins1 insulin 1 multiple interactions EXP hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]] CTD PMID:15172182 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
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  CHEBI ontology 19874
    role 19844
      application 19689
        food additive 16831
          food acidity regulator 11977
            acetic acid 11083
              acetate ester 4056
                hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester 1
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  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      chalcogen 19563
                        oxygen atom 19535
                          oxygen molecular entity 19535
                            hydroxides 19341
                              oxoacid 18777
                                pnictogen oxoacid 14974
                                  phosphorus oxoacid 14577
                                    phosphorus oxoacid derivative 14081
                                      phosphonic acid derivative 2352
                                        phosphonate 186
                                          organic phosphonate 186
                                            hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester 1
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