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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:histamine releasing agent
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Accession:CHEBI:75298 term browser browse the term
Definition:Any substance that can induce the release of histamine from mast cells.
Synonyms:related_synonym: histamine releasing agents;   histamine releasing compound;   histamine releasing compounds;   histamine releasing substance;   histamine releasing substances


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compound 48/80 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of CCL2 protein CTD PMID:34826398 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Gusb glucuronidase, beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Hexa hexosaminidase subunit alpha increases secretion
multiple interactions		 ISO p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein
Apigenin inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein]		 CTD PMID:36350155 NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013 		JBrowse link
G Hexb hexosaminidase subunit beta increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of HEXB protein CTD PMID:34774977 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases activity EXP p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase affects response to substance ISO KIT protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Kng1 kininogen 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity		 EXP atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein] CTD PMID:29402411 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein] CTD PMID:29402411 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 affects response to substance ISO MRGPRX2 protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of TNF protein CTD PMID:34826398 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpsb2 tryptase beta 2 increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of TPSB2 protein CTD PMID:34826398 NCBI chr10:14,381,779...14,383,571
Ensembl chr10:14,382,013...14,383,569 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          histamine releasing agent 14
            compound 48/80 14
            kinetensin 0
            kinetensin (1-8) 0
            kinetensin (1-8)(2+) 0
            kinetensin(2+) 0
paths to the root