phenylarsine oxide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	phenylarsine oxide	go back to main search page
Accession:	CHEBI:75253	browse the term
Definition:	An arsine oxide derived from phenylarsine.
Synonyms:	exact_synonym:	oxo(phenyl)arsine
	related_synonym:	Arsenosobenzene; Formula=C6H5AsO; InChI=1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H; InChIKey=BQVCCPGCDUSGOE-UHFFFAOYSA-N; Oxophenylarsine; PhAsO; Phenyl arsine oxide; Phenylarsenoxide; SMILES=O=[As]c1ccccc1
	xref:	CAS:637-03-6
	xref_mesh:	MESH:C029341
	xref:	PDBeChem:PA0; PMID:22048238; PMID:22617457; PMID:23044393; PMID:23201556; Reaxys:2935227

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Genes (76)

phenylarsine oxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

multiple interactions

oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; oxophenylarsine inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

multiple interactions

oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; oxophenylarsine inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein]

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

activating transcription factor 2

multiple interactions

oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of ATF2 protein]

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

BCAR1 scaffold protein, Cas family member

increases phosphorylation
multiple interactions

oxophenylarsine results in increased phosphorylation of BCAR1 protein
[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

calcium voltage-gated channel subunit alpha1 H

decreases activity

oxophenylarsine results in decreased activity of CACNA1H protein

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

caspase 3

increases activity

oxophenylarsine results in increased activity of CASP3 protein

PMID:10515888 PMID:19465042

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

C-C motif chemokine receptor 3

multiple interactions

oxophenylarsine inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein]

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

G

CD79a molecule

increases phosphorylation

oxophenylarsine results in increased phosphorylation of CD79A protein

NCBI chr 1:80,493,581...80,497,936
Ensembl chr 1:80,493,581...80,497,935

G

CD79b molecule

increases phosphorylation

oxophenylarsine results in increased phosphorylation of CD79B protein

NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625

G

ciliary neurotrophic factor

multiple interactions

oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]; oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein]

NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877

G

cAMP responsive element binding protein 1

multiple interactions

oxophenylarsine inhibits the reaction [Colforsin results in increased activity of CREB1 protein]; oxophenylarsine inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; oxophenylarsine inhibits the reaction [Isoproterenol results in increased phosphorylation of CREB1 protein]; oxophenylarsine inhibits the reaction [Lipopolysaccharides results in increased activity of CREB1 protein]

PMID:17141199 PMID:20512473

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

epidermal growth factor

multiple interactions

oxophenylarsine inhibits the reaction [EGF protein affects the localization of and results in increased activity of STAT3 protein]; oxophenylarsine inhibits the reaction [EGF protein binds to and affects the localization of EGFR protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

oxophenylarsine inhibits the reaction [EGF protein binds to and affects the localization of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

erb-b2 receptor tyrosine kinase 4

multiple interactions

oxophenylarsine results in increased cleavage of and results in increased phosphorylation of ERBB4 protein

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

FYN proto-oncogene, Src family tyrosine kinase

affects localization

oxophenylarsine affects the localization of FYN protein

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

G

growth hormone 1

multiple interactions

oxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]
oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

growth factor receptor bound protein 2

multiple interactions

[oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein]

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

G

heme oxygenase 1

increases expression
multiple interactions

oxophenylarsine results in increased expression of HMOX1 mRNA
Acetylcysteine inhibits the reaction [oxophenylarsine results in increased expression of HMOX1 mRNA]

PMID:8612205 PMID:15368090 PMID:19786557

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

inhibitor of DNA binding 3

affects binding

oxophenylarsine binds to ID3 protein

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

insulin-like growth factor 1

decreases localization
multiple interactions

oxophenylarsine results in decreased localization of IGF1 protein
oxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid]

PMID:1928324 PMID:9145794

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2

decreases localization

oxophenylarsine results in decreased localization of IGF2 protein

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

interleukin 12B

multiple interactions

Colforsin inhibits the reaction [oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]; oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 1 beta

multiple interactions

oxophenylarsine inhibits the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; oxophenylarsine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; oxophenylarsine results in decreased expression of and results in decreased activity of IL1B protein

PMID:9266823 PMID:10515888 PMID:10802230

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 3

multiple interactions

oxophenylarsine inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein]

NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066

G

interleukin 6

multiple interactions

oxophenylarsine inhibits the reaction [Colforsin results in increased secretion of IL6 protein]; oxophenylarsine inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein]
oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of IL6 mRNA]

PMID:17141199 PMID:26763395

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

affects binding
multiple interactions
decreases degradation
decreases activity

oxophenylarsine binds to INS1 protein
Dithiothreitol affects the reaction [oxophenylarsine results in decreased activity of INS1 protein]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of 3-O-Methylglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Glucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Glucose]
oxophenylarsine results in decreased degradation of INS1 protein
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]]; Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; oxophenylarsine inhibits the reaction [INS1 protein affects the transport of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS1 protein results in increased transport of Deoxyglucose]; oxophenylarsine inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]

PMID:1536656 PMID:1629198 PMID:1847587 PMID:2185640 PMID:2202293 More...

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

multiple interactions

Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]]; oxophenylarsine inhibits the reaction [INS protein affects the localization of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

insulin receptor

multiple interactions

oxophenylarsine promotes the reaction [Vanadates results in increased phosphorylation of INSR protein]

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

inositol hexakisphosphate kinase 1

decreases activity

oxophenylarsine results in decreased activity of IP6K1 protein

NCBI chr 8:108,693,068...108,737,278

G

Kelch-like ECH-associated protein 1

affects binding

oxophenylarsine binds to KEAP1 protein

PMID:19786557 PMID:19808700

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

mitogen activated protein kinase 1

multiple interactions

oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]

PMID:11880281 PMID:12927602

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]

PMID:11880281 PMID:12927602

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions
increases phosphorylation

[oxophenylarsine results in increased activity of MARK1 protein] which results in increased phosphorylation of MAPT protein; Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein]

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

microtubule affinity regulating kinase 1

increases activity
multiple interactions

oxophenylarsine results in increased activity of MARK1 protein
[oxophenylarsine results in increased activity of MARK1 protein] which results in increased phosphorylation of MAPT protein; Staurosporine inhibits the reaction [oxophenylarsine results in increased activity of MARK1 protein]

NCBI chr13:96,450,189...96,555,304
Ensembl chr13:96,451,487...96,555,173

G

matrix metallopeptidase 2

multiple interactions

oxophenylarsine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

oxophenylarsine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

metallothionein 1

increases expression

oxophenylarsine results in increased expression of MT1 mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metal-regulatory transcription factor 1

affects binding

oxophenylarsine binds to MTF1 protein

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

mechanistic target of rapamycin kinase

multiple interactions
increases activity

[oxophenylarsine results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]; MTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

neuronal calcium sensor 1

multiple interactions

oxophenylarsine inhibits the reaction [NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]]

NCBI chr 3:14,523,220...14,568,829
Ensembl chr 3:14,523,220...14,568,829

G

NFE2 like bZIP transcription factor 2

increases activity
multiple interactions

oxophenylarsine results in increased activity of NFE2L2 protein
oxophenylarsine binds to and results in increased activity of NFE2L2 protein

PMID:19786557 PMID:19808700

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

affects localization
multiple interactions

oxophenylarsine affects the localization of NFKB1 protein
oxophenylarsine promotes the reaction [Viper Venoms affects the localization of NFKB1 protein]; Viper Venoms promotes the reaction [oxophenylarsine affects the localization of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

decreases phosphorylation
multiple interactions

oxophenylarsine results in decreased phosphorylation of NFKBIA protein
oxophenylarsine promotes the reaction [Viper Venoms results in decreased phosphorylation of NFKBIA protein]; Viper Venoms promotes the reaction [oxophenylarsine results in decreased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 3

affects localization

oxophenylarsine affects the localization of NOS3 protein

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NAD(P)H quinone dehydrogenase 1

increases expression

oxophenylarsine results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

neurotrophin 4

decreases transport

oxophenylarsine results in decreased transport of NTF4 protein

NCBI chr 1:95,893,560...95,896,391
Ensembl chr 1:95,893,457...95,897,243

G

poly (ADP-ribose) polymerase 1

increases cleavage

oxophenylarsine results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phospholipase C, gamma 1

multiple interactions
decreases phosphorylation
affects localization

[oxophenylarsine results in decreased phosphorylation of PLCG1 protein] inhibits the reaction [PLCG1 protein binds to GRB2 protein]
oxophenylarsine affects the localization of PLCG1 protein

PMID:1325458 PMID:9281317 PMID:9546377

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

phospholipase D1

multiple interactions

oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA]; oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein]

NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692

G

PML nuclear body scaffold

multiple interactions

oxophenylarsine results in increased sumoylation of and results in increased ubiquitination of and results in increased degradation of PML protein; oxophenylarsine results in increased sumoylation of and results in increased ubiquitination of and results in increased degradation of PML protein mutant form

NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971

G

proopiomelanocortin

decreases activity
multiple interactions

oxophenylarsine results in decreased activity of POMC protein
oxophenylarsine inhibits the reaction [POMC protein results in increased abundance of Corticosterone]
[oxophenylarsine results in decreased activity of POMC protein] which results in decreased chemical synthesis of Progesterone

PMID:10518784 PMID:12530643

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

prostaglandin-endoperoxide synthase 2

multiple interactions

oxophenylarsine inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]
oxophenylarsine inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]
oxophenylarsine inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]

PMID:9266823 PMID:9576062 PMID:9580637 PMID:18267125

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions
increases phosphorylation

[oxophenylarsine co-treated with oxotremorine M] results in increased phosphorylation of PTK2 protein; [oxophenylarsine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PTK2 protein; [wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]
oxophenylarsine results in increased phosphorylation of PTK2 protein

PMID:10537051 PMID:10569804

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

paxillin

multiple interactions
increases phosphorylation
affects localization

[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]
oxophenylarsine affects the localization of PXN protein

PMID:9546377 PMID:10537051

NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931

G

regulator of calcineurin 1

multiple interactions

oxophenylarsine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RCAN1 protein]

NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045

G

RELA proto-oncogene, NF-kB subunit

affects localization
multiple interactions

oxophenylarsine affects the localization of RELA protein
oxophenylarsine promotes the reaction [Viper Venoms affects the localization of RELA protein]; Viper Venoms promotes the reaction [oxophenylarsine affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ribosomal protein S6 kinase B1

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; [oxophenylarsine results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Dimercaprol inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; MTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [antimycin results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [Deoxyglucose results in decreased phosphorylation of RPS6KB1 protein]; oxophenylarsine inhibits the reaction [Tosyllysine Chloromethyl Ketone results in decreased phosphorylation of RPS6KB1 protein]; RPTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

regulatory associated protein of MTOR, complex 1

multiple interactions

Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]]; oxophenylarsine inhibits the reaction [MTOR protein binds to RPTOR protein]; RPTOR mutant form inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]

NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983

G

solute carrier family 25 member 4

multiple interactions
affects binding

Bongkrekic Acid inhibits the reaction [oxophenylarsine binds to SLC25A4 protein]; carboxyatractyloside inhibits the reaction [oxophenylarsine binds to SLC25A4 protein]

NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733

G

solute carrier family 25 member 5

decreases activity

oxophenylarsine results in decreased activity of SLC25A5 protein

NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967

G

solute carrier family 2 member 1

multiple interactions
affects activity

oxophenylarsine inhibits the reaction [Cytochalasin B binds to SLC2A1 protein]; oxophenylarsine inhibits the reaction [Glucose deficiency results in increased activity of SLC2A1 protein]; oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein]
oxophenylarsine affects the activity of SLC2A1 protein

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 4

multiple interactions
affects binding

oxophenylarsine inhibits the reaction [INS1 protein affects the transport of SLC2A4 protein]
oxophenylarsine binds to SLC2A4 protein
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]]; oxophenylarsine inhibits the reaction [INS protein affects the localization of SLC2A4 protein]; oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]

PMID:1536656 PMID:1629198 PMID:8048502

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

SMAD family member 3

multiple interactions

oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SRC proto-oncogene, non-receptor tyrosine kinase

affects localization

oxophenylarsine affects the localization of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

steroidogenic acute regulatory protein

decreases expression

oxophenylarsine results in decreased expression of STAR protein

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 1

multiple interactions

oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions
affects localization

Hydrogen Peroxide promotes the reaction [oxophenylarsine affects the localization of STAT3 protein]; oxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein]; oxophenylarsine promotes the reaction [Hydrogen Peroxide affects the localization of STAT3 protein]
oxophenylarsine inhibits the reaction [EGF protein affects the localization of and results in increased activity of STAT3 protein]

PMID:10364193 PMID:11882386 PMID:12093727

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tachykinin, precursor 1

multiple interactions

oxophenylarsine inhibits the reaction [TAC1 protein affects the localization of TACR1 protein]

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

tachykinin receptor 1

multiple interactions

oxophenylarsine inhibits the reaction [TAC1 protein affects the localization of TACR1 protein]

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

G

transferrin

decreases uptake

oxophenylarsine results in decreased uptake of TF protein

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transferrin receptor

affects localization

oxophenylarsine affects the localization of TFRC protein

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

transforming growth factor, beta 1

multiple interactions
decreases activity

oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
oxophenylarsine results in decreased activity of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

oxophenylarsine inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]
oxophenylarsine inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]

PMID:9576062 PMID:9580637 PMID:10802230

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 25

multiple interactions
increases expression

oxophenylarsine promotes the reaction [Viper Venoms results in increased expression of TNFRSF25 protein]; Viper Venoms promotes the reaction [oxophenylarsine results in increased expression of TNFRSF25 protein]

NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

oxophenylarsine inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; oxophenylarsine inhibits the reaction [Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]]; oxophenylarsine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

multiple interactions

[oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein; Cyclosporine inhibits the reaction [[oxophenylarsine co-treated with Calcium Chloride] results in decreased phosphorylation of UQCRFS1 protein]

NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19880
role	19850
biological role	19848
biochemical role	19556
apoptosis inducer	13663
phenylarsine oxide	76
Path 2
Term	Annotations
CHEBI ontology	19880
subatomic particle	19878
composite particle	19878
hadron	19878
baryon	19878
nucleon	19878
atomic nucleus	19878
atom	19878
main group element atom	19817
p-block element atom	19817
p-block molecular entity	19817
pnictogen molecular entity	19078
arsenic molecular entity	14690
arsine oxides	107
phenylarsine oxide	76

paths to the root